CN103638403A - Medicine for treating diabetic gangrene and preparation method of medicine - Google Patents
Medicine for treating diabetic gangrene and preparation method of medicine Download PDFInfo
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- CN103638403A CN103638403A CN201310665848.1A CN201310665848A CN103638403A CN 103638403 A CN103638403 A CN 103638403A CN 201310665848 A CN201310665848 A CN 201310665848A CN 103638403 A CN103638403 A CN 103638403A
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Abstract
The invention discloses a medicine for treating medicine for treating diabetic gangrene and a preparation method of the medicine. The medicine is mainly prepared from astragalus membranaceus, radix scrophulariae, achyranthes bidentata, prepared rehmannia, honeysuckle, heterophylly falsestarwort root, motherwort, red peony root, radix ophiopogonis and other medicines in a certain weight ratio. The medicine has the functions of clearing heat and cooling blood, eliminating stasis and removing toxicity, is quick in response and good in curative effect when used for treating diabetic gangrene, and does not have toxic or side effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of diabetic acromelic gangrene and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Diabetic acromelic gangrene is that a kind of chronic progressive external involves big or middle, the microvascular special pathological changes of limbs, and take acral pain, infection, ulcer, gangrene is main clinical characteristics.This disease is one of complication that diabetes are the most serious.This patient is and toes ulcer inaccessible with large artery trunks usually.And this toes ulcer is perception gangrene; If patient is without arterial occlusion, ulcer is located to send out in its sufficient edge, vola, instep etc., and this ulcer is that wet gangrene, this disease are mainly in not good control due to blood glucose of diabetics.Diabetic acromelic gangrene betides middle-aged and elderly people mostly; Man is more than female, and men and women's ratio is 3:2; Diabetic duration on average approximately 10 years, gangrenous position lower limb are common, account for 92.5%, and upper limb is rare, and morbidity accounts for 80%, and bilateral is fallen ill and is accounted for 20% simultaneously; Toes and vola be gangrene common simultaneously, accounts for 77.5%; Toes and shank simultaneously gangrene account for 5%, and only shank gangrene accounts for 5%; Toes or finger morbidity account for 12.5%.At present, diabetes treatment by western medicine acromelic gangrene poor effect, and long-term taking Western medicine has more side effect, and therefore, there is very large demand to the Chinese medicine of effective treatment diabetic acromelic gangrene in people.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment diabetic acromelic gangrene, thereby has completed the present invention.
Object of the present invention is just to provide a kind of composition of medicine that can effectively treat diabetic acromelic gangrene.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects the Radix Astragali, Radix Scrophulariae, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Flos Lonicerae, Radix Pseudostellariae, Herba Leonuri, Radix Paeoniae Rubra, Radix Ophiopogonis, Radix Angelicae Sinensis, Caulis Spatholobi, the Rhizoma Anemarrhenae, Lumbricus, Lignum Sappan, Radix Trichosanthis, Herba Epimedii, Semen Coicis, Rhizoma Atractylodis, Cortex Moutan, Radix Gentianae, Flos Carthami, Herba Violae, Radix Aconiti Lateralis Preparata, Rhizoma Sparganii, Herba Eupatorii, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cimicifugae, Radix Rhapontici, Rhizoma Corydalis, Concha Margaritifera medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thus recurrence that can rapid, effective treatment diabetic acromelic gangrene.Wherein select the Radix Astragali to be because its nature and flavor are sweet, tepor, enters lung, spleen channel, raw with the useful consolidating superficial resistance of defending, inducing diuresis to remove edema, and poison holding, the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or is burst and hold back for a long time; Process by the function that has invigorating middle warmer benefit, control internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Radix Scrophulariae to be because its nature and flavor are bitter, salty, cool, enter lung, kidney channel, have YIN nourishing, pathogenic fire reducing, relieving restlessness, the function of removing toxic substances, controls calentura excessive thirst, sends out speckle, and hectic fever due to YIN-deficiency consumptive fever, sleeps not peaceful night, spontaneous sweating, constipation is hindered in Tianjin, hematemesis and epistaxis, laryngopharynx swelling and pain, carbuncle, scrofula.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and the function of subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury, ripe in invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Select Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor, enters liver, kidney channel, has YIN nourishing, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, waist knee flaccidity, and chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deafness, blurred vision.Select Flos Lonicerae to be because its nature and flavor are sweet, cold, enter lung, stomach warp, there is heat clearing away, the function of removing toxic substances, controls epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Selecting Radix Pseudostellariae is that tepor, enters the heart, spleen, lung three warps, has the function of tonifying the lung, spleen invigorating, controls cough due to deficiency of the lung because of its nature and flavor sweetness and bitterness, insufficiency of the spleen lack of appetite, and cardiopalmus order antiperspirant, spirit is tired.Select Herba Leonuri to be because its nature and flavor are arduous, cool, enter pericardium, Liver Channel, invigorate blood circulation, blood stasis dispelling, regulating menstruation, the function of the water that disappears, controls menoxenia, controls Lou difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, controls warm poison and goes mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass stomachache, injury from falling down, carbuncle skin infection.Select be Radix Ophiopogonis because its property sweet and slightly bitter taste is cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid, controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, thirsty clearly, calentura Tianjin wound, dry mouth and throat, constipation.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Selecting Caulis Spatholobi is because its property bitter but sweet flavor, and temperature, enters the heart, spleen two warps, have invigorate blood circulation, the function of relaxing muscles and tendons, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select the Rhizoma Anemarrhenae to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, there is nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Lumbricus to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, there is heat clearing away, suppressing the hyperactive liver, Zhichuan, the function of dredging collateral, control height fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia, pants, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select Lignum Sappan to be because its nature and flavor are sweet, salty, flat, have promoting the circulation of blood, removing blood stasis with potent drugs, detumescence, the function of pain relieving, controls married woman's vim and vigour cardiac and abdominal pain, amenorrhea, postnatal blood stasis, distending pain dyspnea with rapid respiration, dysentery, tetanus.Select Radix Trichosanthis to be because its nature and flavor sweetness and bitterness acid is cool, enter lung, stomach warp, have and promote the production of body fluid, quench the thirst, pathogenic fire reducing, moisturizes, evacuation of pus, and the function of detumescence, controls calentura thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.Selecting Herba Epimedii is that temperature, enters liver, kidney channel, has kidney invigorating and YANG supporting because of its property acrid-sweet flavor, and the function of expelling wind and removing dampness is controlled sexual impotence erectile problem, dribbling urination, and muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.Select Semen Coicis to be because its property slightly sweet flavor is cool, enter spleen, lung, kidney channel, have spleen invigorating, tonifying the lung, heat clearing away, the function of dampness removing, controls and has loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.Select Rhizoma Atractylodis to be because its nature and flavor are arduous, temperature, enters spleen, stomach warp, has spleen invigorating, dampness, and resolving depression, wards off dirty function, control the wet tired spleen of containing, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Select Cortex Moutan to be because its nature and flavor are arduous, cool, enter the heart, liver, kidney channel, have heat clearing away, removing heat from blood, and blood, the function of repercussive, controls the pathogenic heat attacking blood system in febrile diseases, sends out speckle ， Jing Epilepsy, and tell, be defeated in battle, have blood in stool, hectic fever due to YIN-deficiency consumptive fever, amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.Select Radix Gentianae to be because its nature and flavor are bitter, cold, enter liver, gallbladder meridian, there is eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat ， Jing Epilepsy, encephalitis B, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Select Flos Carthami to be because its nature and flavor are pungent, temperature, enters the heart, Liver Channel, has promoting blood circulation to restore menstrual flow, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Herba Violae to be because its nature and flavor are bitter, cold, enter the heart, Liver Channel, there is clearing away heat-damp and promoting diuresis, the function of removing toxic substances and promoting subsidence of swelling, controls furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom.Selecting Radix Aconiti Lateralis Preparata is because of its property acrid-sweet flavor, and heat is poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted contrary, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia ， Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Select Rhizoma Sparganii to be because its nature and flavor toil is flat, enter liver, spleen channel, have removing blood stasis, circulation of qi promoting, removing food stagnancy, the function ， Zhi lumps in the chest and abdomen of pain relieving, the solidifying band of QI and blood, trusted subordinate's pain, the lower swollen pain of the side of body, amenorrhea, postnatal blood stasis stomachache, traumatic injury, skin ulcer is swollen hard.Select Herba Eupatorii to be because its nature and flavor are pungent, flat, enter spleen, stomach warp, have clearing away summer-heat, ward off dirty, removing dampness, the function of regulating menstruation, controls and experiences heat-damp in summer, cold and heat headache, accumulates in damp, gastral cavity painful abdominal mass is not hungry, sweet taste in the mouth greasy fur, menoxenia.Select Pseudobulbus Bletillae (Rhizoma Bletillae) to be because its property bitter but sweet flavor is cool, enter lung meridian, have tonifying the lung, hemostasis, detumescence, raw sight, the function of sore, controls lung and hinders hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, ulcer pain, soup fire is burnt, rhagadia manus et pedis.Select Rhizoma Cimicifugae to be because the sweet pungent micro-hardship of its nature and flavor is cool, enter lung, spleen, stomach warp, have yang invigorating, deliver rash, the function of removing toxic substances, controls seasonal epidemic pathogens epidemic disease labor, headache cold and heat, and laryngalgia, aphtha scar, macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus tenesmus, carbuncle sore tumefacting virus.Select Radix Rhapontici to be because its nature and flavor hardship is salty-cold, enter stomach, large intestine channel, have heat-clearing and toxic substances removing, the function of stimulating milk secretion, controls the swollen pain of breast, galactostasis, toxic-heat and blood stasis, arthralgia.Select Rhizoma Corydalis to be because its nature and flavor are arduous, temperature, enters liver, stomach warp, invigorates blood circulation, and dissipating blood stasis, regulates the flow of vital energy, and the function of pain relieving is controlled all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.Select Concha Margaritifera to be because its nature and flavor are salty, cool, enter the heart, liver two warps, have suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, the function of hemostasis, controls dizziness, tinnitus, cardiopalmus, insomnia, demented ， Jing Epilepsy, spits blood, epistaxis, metrorrhagia.
The specific embodiment
The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Radix Astragali 15-25 gram of Radix Scrophulariae 15-25 gram of Radix Achyranthis Bidentatae 15-25 gram
Radix Rehmanniae Preparata 10-20 gram of Flos Lonicerae 10-20 gram of Radix Pseudostellariae 25-35 gram
Herba Leonuri 5-15 gram Radix Paeoniae Rubra 5-15 gram Radix Ophiopogonis 10-20 gram
Radix Angelicae Sinensis 10-20 gram of Caulis Spatholobi 10-20 gram of Rhizoma Anemarrhenae 25-35 gram
Lumbricus 10-20 gram of Lignum Sappan 10-15 gram of Radix Trichosanthis 5-15 gram
Herba Epimedii 5-15 gram of Semen Coicis 5-15 gram of Rhizoma Atractylodis 15-25 gram
5-15 gram of Flos Carthami 10-20 gram of Cortex Moutan 5-15 cron gallbladder
Herba Violae 6-12 gram of Radix Aconiti Lateralis Preparata 5-15 gram of Rhizoma Sparganii 5-15 gram
Herba Eupatorii 10-15 gram of Pseudobulbus Bletillae (Rhizoma Bletillae) 3-9 gram liter fiber crops 3-9 gram
Radix Rhapontici 10-20 gram of Rhizoma Corydalis 10-20 gram of Concha Margaritifera 25-35 gram
Preferable amount is
20 grams of 20 grams of Radix Achyranthis Bidentataes of 20 grams of Radix Scrophulariaes of the Radix Astragali
30 grams of 15 grams of Radix Pseudostellariaes of 15 grams of Flos Loniceraes of Radix Rehmanniae Preparata
15 grams of 10 grams of Radix Paeoniae Rubra of Herba Leonuri 10 grams of Radix Ophiopogonis
30 grams of 15 grams of Rhizoma Anemarrhenaes of 15 grams of Caulis Spatholobis of Radix Angelicae Sinensis
10 grams of 12 grams of Radix Trichosanthis of 15 grams of Lignum Sappans of Lumbricus
20 grams of 10 grams of Rhizoma Atractylodis of 10 grams of Semen Coiciss of Herba Epimedii
15 grams, 10 grams of Flos Carthamis of Cortex Moutan 10 cron gallbladder
10 grams of 10 grams of Rhizoma Sparganii of 9 grams of Radix Aconiti Lateralis Preparatas of Herba Violae
6 grams of 12 grams of Pseudobulbus Bletillae (Rhizoma Bletillae) of Herba Eupatorii, 6 gram liter fiber crops
30 grams of 15 grams of Concha Margaritiferas of 15 grams of Rhizoma Corydalis of Radix Rhapontici
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, the Radix Astragali: choose clean impurity, remove residual root head and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;
2, Radix Scrophulariae: choose clean impurity, except removing LU, clean and run through, section, dries;
3, Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
4, Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, shines when dry to eighty per cant, section, is dried;
5, Flos Lonicerae: sieve removes silt, chooses clean impurity;
6, Radix Pseudostellariae: extract fibrous root, dry;
7, Herba Leonuri: choose decontamination, clean, run through, cutting, dries;
8, Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, cleans, runs through, shave, and dry, sieve removes chip;
9, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, pump the heart after running through, then clean and dry;
10, Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air when even to inside and outside humidity, and section is dried;
11, Caulis Spatholobi: water runs through, section, or steam after soft and take advantage of fervent sheet, dry;
12, the Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, softens, and section is dried;
13, Lumbricus: choose decontamination, water rinses, and pulls out in time, dries cutting;
14, Lignum Sappan: get crude drug, be sawn into short section, then be split into fragment or pound sheet;
15, Radix Trichosanthis: choose decontamination, size block separately, saturating with blister sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, and pulls out, shines extremely dryly, smashes into fritter;
16, Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip;
17, Semen Coicis: get crude drug, remove residual cot, impurity;
18, Rhizoma Atractylodis: choose decontamination, with blister to seven, most probably saturating, pull out, run through rear section, dry;
19, Cortex Moutan: choose decontamination, remove core, clean, run through, section, dries;
20, Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
21, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
22, Herba Violae: choose clean impurity, water washes away earth, cutting is dried;
23, Radix Aconiti Lateralis Preparata: be soaked in water, pull out, section, dries;
24, Rhizoma Sparganii: choose clean impurity, be soaked in water, pull out and run through, section, dries;
25, Herba Eupatorii: choose clean impurity, wash, pull out, slightly, after profit, remove undesirable root, cutting, dries;
26, Pseudobulbus Bletillae (Rhizoma Bletillae): choose decontamination, be soaked in water, pull out, run through, section, dry;
27, Rhizoma Cimicifugae: choose decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;
28, Radix Rhapontici: choose clean impurity, unhairing is cleaned, and runs through, and section, dries;
29, Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
30, Concha Margaritifera: choose decontamination, knock fragment, sieve dedust bits.
Two, preparation
1, by the Radix Astragali of described weight, Radix Scrophulariae, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Flos Lonicerae, Radix Pseudostellariae, Herba Leonuri, Radix Paeoniae Rubra, Radix Ophiopogonis, Radix Angelicae Sinensis, Caulis Spatholobi, the Rhizoma Anemarrhenae, Lumbricus, Lignum Sappan, Radix Trichosanthis, Herba Epimedii, Semen Coicis, Rhizoma Atractylodis, Cortex Moutan, Radix Gentianae, Flos Carthami, Herba Violae, Radix Aconiti Lateralis Preparata, Rhizoma Sparganii, Herba Eupatorii, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cimicifugae, Radix Rhapontici, Rhizoma Corydalis, Concha Margaritifera medicine decocts with water secondary, add for the first time 8 times of amounts of water, soak after 120 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 25 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time.
2, the medicinal residues of filtration are added to 6 times of amounts of water, first boil with high heat, then use slow fire boiling 40 minutes, filter to obtain decoction liquor for the second time.
3, twice decoction liquor carried out to mixing and stirring, be divided into 6 doses and take.
Medicine of the present invention has heat clearing away, removing heat from blood, and blood, and repercussive, the function of expectorant, is used for the treatment of diabetic acromelic gangrene, short treating period, instant effect, non-relapse after healing, has no side effect.
By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.4kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] drug treatment of diabetic acromelic gangrene of the present invention
1, physical data
Accept out-patient's totally 168 examples for medical treatment.
2, diagnostic criteria
Clinical acromelic gangrene is divided into wet gangrene, dry gangrene and mixed type gangrene.
(1) wet gangrene.Acra body surface local soft tissue is rotten to the corn, forms fester, and then fester and go deep into flesh layer, rotten disconnected tendon very, sclerotin is damaged, and a large amount of tissue necrosiss, form large vomica, discharge more secretions.This kind of gangrene is common, accounts for 72.5%, and main pathological basis is microcirculation disturbance due to blood capillary basement membrane thickened.
(2) dry gangrene.The acra tip ischemic necrosis of getting involved, withered blackening, lesion boundaries is clear, and being developed to that certain phase is not treated can self falling.This kind of gangrene accounts for 7.5%, ischemic necrosis due to small artery obturation.
(3) mixed type gangrene.Account for 20%.Microcirculation disturbance and small artery block two class pathological changes and deposit, and the ischemia mummification necrosis of existing acra has again the wet gangrene of foot and (or) shank.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day, early, middle and late respectively clothes 1 time, 10 days was a course for the treatment of, took continuously 7 courses for the treatment of.
4, efficacy assessment standard
Effective: transference cure, it is normal that body constitution is recovered, and observes half a year without recidivist;
Take a turn for the better: symptom is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by drug treatment of diabetic acromelic gangrene patient of the present invention 168 examples, effective 159 examples of result, obvious effective rate is 94.64%, 6 examples that take a turn for the better, and improvement rate is 3.57%, invalid 3 examples, total effective rate is 98.21%.
Claims (3)
1. a medicine for the treatment of diabetic acromelic gangrene, is characterized in that: it is to be made by the crude drug in following weight range:
Radix Astragali 15-25 gram of Radix Scrophulariae 15-25 gram of Radix Achyranthis Bidentatae 15-25 gram
Radix Rehmanniae Preparata 10-20 gram of Flos Lonicerae 10-20 gram of Radix Pseudostellariae 25-35 gram
Herba Leonuri 5-15 gram Radix Paeoniae Rubra 5-15 gram Radix Ophiopogonis 10-20 gram
Radix Angelicae Sinensis 10-20 gram of Caulis Spatholobi 10-20 gram of Rhizoma Anemarrhenae 25-35 gram
Lumbricus 10-20 gram of Lignum Sappan 10-15 gram of Radix Trichosanthis 5-15 gram
Herba Epimedii 5-15 gram of Semen Coicis 5-15 gram of Rhizoma Atractylodis 15-25 gram
5-15 gram of Flos Carthami 10-20 gram of Cortex Moutan 5-15 cron gallbladder
Herba Violae 6-12 gram of Radix Aconiti Lateralis Preparata 5-15 gram of Rhizoma Sparganii 5-15 gram
Herba Eupatorii 10-15 gram of Pseudobulbus Bletillae (Rhizoma Bletillae) 3-9 gram liter fiber crops 3-9 gram
Radix Rhapontici 10-20 gram of Rhizoma Corydalis 10-20 gram of Concha Margaritifera 25-35 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
20 grams of 20 grams of Radix Achyranthis Bidentataes of 20 grams of Radix Scrophulariaes of the Radix Astragali
30 grams of 15 grams of Radix Pseudostellariaes of 15 grams of Flos Loniceraes of Radix Rehmanniae Preparata
15 grams of 10 grams of Radix Paeoniae Rubra of Herba Leonuri 10 grams of Radix Ophiopogonis
30 grams of 15 grams of Rhizoma Anemarrhenaes of 15 grams of Caulis Spatholobis of Radix Angelicae Sinensis
10 grams of 12 grams of Radix Trichosanthis of 15 grams of Lignum Sappans of Lumbricus
20 grams of 10 grams of Rhizoma Atractylodis of 10 grams of Semen Coiciss of Herba Epimedii
15 grams, 10 grams of Flos Carthamis of Cortex Moutan 10 cron gallbladder
10 grams of 10 grams of Rhizoma Sparganii of 9 grams of Radix Aconiti Lateralis Preparatas of Herba Violae
6 grams of 12 grams of Pseudobulbus Bletillae (Rhizoma Bletillae) of Herba Eupatorii, 6 gram liter fiber crops
30 grams of 15 grams of Concha Margaritiferas of 15 grams of Rhizoma Corydalis of Radix Rhapontici.
3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Radix Astragali: choose clean impurity, remove residual root head and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;
(2) Radix Scrophulariae: choose clean impurity, except removing LU, clean and run through, section, dries;
(3) Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
(4) Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, shines when dry to eighty per cant, section, is dried;
(5) Flos Lonicerae: sieve removes silt, chooses clean impurity;
(6) Radix Pseudostellariae: extract fibrous root, dry;
(7) Herba Leonuri: choose decontamination, clean, run through, cutting, dries;
(8) Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, cleans, runs through, shave, and dry, sieve removes chip;
(9) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, pump the heart after running through, then clean and dry;
(10) Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air when even to inside and outside humidity, and section is dried;
(11) Caulis Spatholobi: water runs through, section, or steam after soft and take advantage of fervent sheet, dry;
(12) Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, softens, and section is dried;
(13) Lumbricus: choose decontamination, water rinses, and pulls out in time, dries cutting;
(14) Lignum Sappan: get crude drug, be sawn into short section, then be split into fragment or pound sheet;
(15) Radix Trichosanthis: choose decontamination, size block separately, saturating with blister sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, and pulls out, shines extremely dryly, smashes into fritter;
(16) Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip;
(17) Semen Coicis: get crude drug, remove residual cot, impurity;
(18) Rhizoma Atractylodis: choose decontamination, with blister to seven, most probably saturating, pull out, run through rear section, dry;
(19) Cortex Moutan: choose decontamination, remove core, clean, run through, section, dries;
(20) Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
(21) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
(22) Herba Violae: choose clean impurity, water washes away earth, cutting is dried;
(23) Radix Aconiti Lateralis Preparata: be soaked in water, pull out, section, dries;
(24) Rhizoma Sparganii: choose clean impurity, be soaked in water, pull out and run through, section, dries;
(25) Herba Eupatorii: choose clean impurity, wash, pull out, slightly, after profit, remove undesirable root, cutting, dries;
(26) Pseudobulbus Bletillae (Rhizoma Bletillae): choose decontamination, be soaked in water, pull out, run through, section, dry;
(27) Rhizoma Cimicifugae: choose decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;
(28) Radix Rhapontici: choose clean impurity, unhairing is cleaned, and runs through, and section, dries;
(29) Rhizoma Corydalis: choose decontamination, be soaked in water, clean, solarization is dried in the air, and profit is even to inside and outside humidity, cuts into slices or smashes;
(30) Concha Margaritifera: choose decontamination, knock fragment, sieve dedust bits;
(2) preparation
(1) by the Radix Astragali of described weight, Radix Scrophulariae, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Flos Lonicerae, Radix Pseudostellariae, Herba Leonuri, Radix Paeoniae Rubra, Radix Ophiopogonis, Radix Angelicae Sinensis, Caulis Spatholobi, the Rhizoma Anemarrhenae, Lumbricus, Lignum Sappan, Radix Trichosanthis, Herba Epimedii, Semen Coicis, Rhizoma Atractylodis, Cortex Moutan, Radix Gentianae, Flos Carthami, Herba Violae, Radix Aconiti Lateralis Preparata, Rhizoma Sparganii, Herba Eupatorii, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Cimicifugae, Radix Rhapontici, Rhizoma Corydalis, Concha Margaritifera medicine decocts with water secondary, add for the first time 8 times of amounts of water, soak after 120 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 25 minutes, filter to obtain decoction liquor for the first time, decoction liquor is poured in container for the first time,
(2) medicinal residues of filtration are added to 6 times of amounts of water, first boil with high heat, then use slow fire boiling 40 minutes, filter to obtain decoction liquor for the second time;
(3) twice decoction liquor carried out to mixing and stirring, be divided into 6 doses and take.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104027662A (en) * | 2014-02-23 | 2014-09-10 | 刘静 | Traditional Chinese medicine for treating diabetic foot and preparing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1369297A (en) * | 2002-03-15 | 2002-09-18 | 刘凤义 | 'Sishen Tongmai' mixture and its preparing process |
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| CN1369297A (en) * | 2002-03-15 | 2002-09-18 | 刘凤义 | 'Sishen Tongmai' mixture and its preparing process |
Non-Patent Citations (2)
| Title |
|---|
| 张建强，等: "糖尿病足肢端坏疽临床研究与治疗进展", 《现代中西医结合杂志》 * |
| 邓秀娟: "浅谈中医药治疗糖尿病肢端坏疽", 《中国中医药信息杂志》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104027662A (en) * | 2014-02-23 | 2014-09-10 | 刘静 | Traditional Chinese medicine for treating diabetic foot and preparing method thereof |
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