CN103191368B - Medicine for treating leucoderma and preparation method thereof - Google Patents
Medicine for treating leucoderma and preparation method thereof Download PDFInfo
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- CN103191368B CN103191368B CN201310107706.3A CN201310107706A CN103191368B CN 103191368 B CN103191368 B CN 103191368B CN 201310107706 A CN201310107706 A CN 201310107706A CN 103191368 B CN103191368 B CN 103191368B
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Abstract
The invention discloses a medicine for treating leucoderma and a preparation method thereof. The medicine is prepared from ligusticum wallichii, fiveleaf akebia fruit, lithospermum, artemisia anomala, motherwort fruit, fructus psoraleae, duckweed and the like according to a certain weight ratio. The medicine disclosed by the invention has the functions of smoothing liver and regulating vital energy, activating blood and dissolving stasis, and clearing away heat and toxic materials, good in curative effect and high in recovery rate in treatment of leucoderma, and fast becomes effective.
Description
Technical field
The present invention relates to a kind of leukodermic medicine and preparation method thereof for the treatment of, belong to the field of Chinese medicines.
Technical background
Vitiligo is a kind of common multiple pigmented dermatosis, and this disease be take local or general property depigmentation, and to form white macula be feature, and skin lesion is local depigmentation speckle, is Chalk color, can turn red after bouncing.Leukodermic sickness rate is very high, has 1-2 people's morbidities in every 100 people of China.Wherein half just started to occur skin lesion before 20 years old, and about 1/5 people has family history.Vitiligo is brought very large injury to patient's physical and mental health, and at present, Western medicine is effective curing vitiligo fast, and has more side effect, and therefore, people exist very large demand to the leukodermic Chinese medicine of rapid, effective treatment.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the leukodermic medicine of effective treatment, thereby has completed the present invention.
Object of the present invention is just to provide a kind ofly can effectively treat leukodermic composition of medicine.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Rhizoma Chuanxiong, Fructus Akebiae, Radix Arnebiae (Radix Lithospermi), Herba Artemisiae Anomalae, Semen Astragali Complanati, Fructus Leonuri, Fructus Psoraleae, Herba Spirodelae, Radix Achyranthis Bidentatae, Radix Sanguisorbae, Fructus Rubi, Fructus Jujubae, Fructus Mori, Semen Persicae, Radix Curcumae, Radix Asparagi, the Radix Angelicae Dahuricae, Herba Ecliptae, Radix Paeoniae Rubra, Herba Leonuri medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat leukodermic recurrence.Wherein select Rhizoma Chuanxiong to be because its nature and flavor are pungent, temperature, enters liver, gallbladder meridian, has activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Fructus Akebiae to be because its nature and flavor are sweet, cold, there is liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, the function of relieving restlessness diuresis, treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, dysentery, lumbago, hypochondriac pain, hernia, dysmenorrhea, uterus tenesmus.Select Radix Arnebiae (Radix Lithospermi) to be because its nature and flavor earnestly, cold, enter percardium, Liver Channel, have removing heat from blood, invigorate blood circulation, the function of heat-clearing and toxic substances removing, controls warm macule, jaundice due to damp-heat, purpura, tells, nosebleed, hematuria, stranguria with turbid discharge, dysentery, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.Select Herba Artemisiae Anomalae to be because its nature and flavor are bitter, temperature, enters the heart, spleen channel, has removing blood stasis to stimulate the menstrual flow, and the function of healing up sore and subduing swelling, controls amenorrhea and mass in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.Select Semen Astragali Complanati to be because it is sweet in flavor and warm in property, enter liver, kidney channel, have tonifying liver, kidney tonifying, improving eyesight, the function of controlling nocturnal emission with astringent drugs, treating the liver kidney deficiency, soreness of waist and knee joint, blurred vision, seminal emission premature ejaculation, frequent micturition, the enuresis, hematuria, leucorrhea.Select Fructus Leonuri to be because its nature and flavor are sweet pungent, cool, enter heart born of the same parents, Liver Channel, have promoting blood flow to regulate menstruation, the function of wind and heat dispersing, controls menoxenia, metrorrhagia leukorrhagia, and postnatal blood stasis is had a pain, liver-heat headache, conjunctival congestion and swelling pain, or raw nebula film.Select Fructus Psoraleae to be because its nature and flavor are pungent, temperature.Enter kidney channel.Reinforcing the kidney and supporting YANG.Control the cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed.Select Herba Spirodelae to be because its nature and flavor are pungent, cold, enter lung meridian, there is diaphoresis, dispel the wind, row water, heat clearing away, the function of removing toxic substances, row calentura while controlling, macule is not saturating, wind heat urticaria, skin pruritus, edema, the difficulty in urination, skin ulcer tinea, erysipelas, scalds.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury, ripe in invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, four fertile contractures, flaccidity syndrome and arthralgia syndrome.Select Radix Sanguisorbae to be because its nature and flavor picric acid, cold.Enter liver, large intestine channel.Cooling blood for hemostasis, heat-clearing and toxic substances removing.Control haematemesis, epistaxis, dysentery, collapse, hemorrhoidal hamorrhage, anal fistula, carbuncle, eczema, incised wound, burn.Select Fructus Rubi to be because its nature and flavor are sweet, acid, flat, enter liver, kidney two warps, there is invigorating the liver and kidney, urine reducing, supporing yang, controlling nocturnal emission with astringent drugs, the function of improving eyesight, controls sexual impotence, seminal emission, frequency of micturition, incontinence of urine, asthenia, order is dark.With Fructus Jujubae, be that temperature, enters spleen, stomach warp, has spleen reinforcing stomach function regulating because its nature and flavor are sweet, supplementing QI for promoting the production of body fluid, adjusts battalion to defend, and separates the function of poison of drug, controls insufficiency of stomach lack of appetite, the weak loose stool of spleen, and qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.Select Fructus Mori to be because its nature and flavor are sweet, cold, enter liver, kidney channel, there is tonifying liver, kidney tonifying, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows the function of liquid, controls hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Select Semen Persicae to be because its property bitter but sweet flavor is flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select Radix Curcumae to be because its nature and flavor are arduous, cool, enter the heart, lung, Liver Channel, have circulation of qi promoting solution with, the function of removing heat from blood removing blood stasis with potent drugs, controls all pains of breast abdomen side of body rib, loses the heart demented, calentura coma, spits blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.Select Radix Asparagi to be because its nature and flavor sweetness and bitterness is cold, enter lung, kidney channel, have YIN nourishing, moisturize, lung heat clearing, the function of pathogenic fire reducing, controls fever due to yin deficiency, and cough is spitted blood, consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quenches one's thirst, constipation.Select the Radix Angelicae Dahuricae to be because its nature and flavor are pungent, temperature, enters lung, spleen, stomach warp, dispel the wind, and dampness, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Herba Ecliptae to be because its nature and flavor picric acid is cool, enter liver, kidney channel, have removing heat from blood, hemostasis, the kidney invigorating, the function of tonifying YIN, controls haematemesis, hemoptysis, epistaxis, hematuria, has blood in stool, dysentery, knife injury is hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, dysentery, pudendum pruritus due to damp pathogen.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, controls warm poison and goes mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， Epilepsy abdominal mass stomachache, injury from falling down, carbuncle skin infection.Select Herba Leonuri to be because its nature and flavor are arduous, cool, enter pericardium, Liver Channel, invigorate blood circulation, blood stasis dispelling, regulating menstruation, the function of the water that disappears, controls menoxenia, controls Lou difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.
The specific embodiment
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Rhizoma Chuanxiong 5-15 gram of Fructus Akebiae 10-15 gram of Radix Arnebiae (Radix Lithospermi) 6-15 gram
Herba Artemisiae Anomalae 15-25 gram of Semen Astragali Complanati 10-15 gram of Fructus Leonuri 10-15 gram
Fructus Psoraleae 15-25 gram of Herba Spirodelae 10-15 gram of Radix Achyranthis Bidentatae 6-15 gram
Radix Sanguisorbae 10-15 gram of Fructus Rubi 5-10 gram of Fructus Jujubae 5-15 gram
Fructus Mori 15-25 gram of Semen Persicae 2-8 gram of Radix Curcumae 5-13 gram
Radix Asparagi 5-15 gram of Radix Angelicae Dahuricae 10-15 gram of Herba Ecliptae 10-15 gram
Radix Paeoniae Rubra 5-10 gram of Herba Leonuri 10-20 gram
Preferable amount is
9 grams of 12 grams of Radix Arnebiae (Radix Lithospermi)s of 10 grams of Fructus Akebiaes of Rhizoma Chuanxiong
12 grams of 12 grams of Fructus Leonuris of 20 grams of Semen Astragali Complanatis of Herba Artemisiae Anomalae
9 grams of 12 grams of Radix Achyranthis Bidentataes of 20 grams of Herba Spirodelaes of Fructus Psoraleae
10 grams, 7 grams of Fructus Jujubaes of 12 grams of Fructus Rubies of Radix Sanguisorbae
8 grams of 5 grams of Radix Curcumaes of 20 grams of Semen Persicaes of Fructus Mori
12 grams of 12 grams of Herba Ecliptaes of 10 grams of Radixs Angelicae Dahuricae of Radix Asparagi
15 grams of 7 grams of Herba Leonuris of Radix Paeoniae Rubra
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
2, Fructus Akebiae: clean, slightly soak, moistening is to saturating, and section is dried, or cleans and dry, and the used time smashs to pieces;
3, Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries;
4, Herba Artemisiae Anomalae: choose clean impurity, remove root, water edulcoration, slightly soaks, and cutting is dried;
5, Semen Astragali Complanati: choose decontamination, rinse silt, pull out, dry;
6, Fructus Leonuri: extract Herb during fruit maturation, dry, lay fruit, choose debranching leaf, well sifted impurity;
7, Fructus Psoraleae: the most impurity of winnowing with a dustpan, clean, dry;
8, Herba Spirodelae: 6-9 fishes between the month, shines scholar;
9, Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
10, Radix Sanguisorbae: choose decontamination, wash, slightly soak, run through, be cut into sheet, dry;
11, Fructus Rubi: sieve dedust bits, choose clean impurity, remove handle;
12, Fructus Jujubae: choose clean impurity, dry;
13, Fructus Mori: wash, choose decontamination, extract long handle, dry;
14, Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;
15, Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section, dries;
16, Radix Asparagi: choose decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, dry;
17, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;
18, Herba Ecliptae: choose clean impurity, remove undesirable root, clean vexed, cutting is dried;
19, Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, cleans, runs through, shave, and dry, sieve removes chip;
20, Herba Leonuri: choose decontamination, clean, run through, cutting, dries.
Two, preparation
1, the Rhizoma Chuanxiong of described weight, Fructus Akebiae, Radix Arnebiae (Radix Lithospermi), Herba Artemisiae Anomalae, Semen Astragali Complanati, Fructus Leonuri, Fructus Psoraleae, Herba Spirodelae, Radix Achyranthis Bidentatae, Radix Sanguisorbae, Fructus Rubi, Fructus Jujubae, Fructus Mori, Semen Persicae, Radix Curcumae, Radix Asparagi, the Radix Angelicae Dahuricae, Herba Ecliptae, Radix Paeoniae Rubra, Herba Leonuri medicine being added to 6 times of water gagings soaks, soak after 120 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling 20 minutes, decoction liquor is poured in container for the first time again.
2, add for the second time 3 times of amounts of water, intense fire decocts boiling 10 minutes, then uses slow fire boiling 20 minutes, obtains decoction liquor for the second time.
3, twice decoction liquor mixed, then simmer in water 10 minutes, decoction liquor is divided into 4 doses and takes.
Medicine of the present invention has the effect of liver-smoothing, qi-regulating, promoting blood circulation to remove blood stasis, heat-clearing and toxic substances removing, is used for the treatment of vitiligo, short treating period, instant effect, non-relapse after healing, has no side effect.
The specific embodiment
By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 40 of rabbit, male and female dual-purpose, body weight 2.0-2.3kg, divides two groups, and 30 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The leukodermic clinical observation material of [test example 2] Drug therapy of the present invention
1, physical data
Accept out-patient's totally 180 examples for medical treatment, its male patient's 120 examples, female patient 60 examples.
2, diagnostic criteria
Vitiligo clinical manifestation: white speckle or the patch of depigmentation appears in skin surface.It is around normal skin.Decolouring speckle differs in size from several millimeters to several centimetres, and in progressive stage, skin lesion can expand gradually, and constantly has new decolouring speckle to occur.The more shallow patient of the colour of skin, white macula can be not obvious, but dark-complexioned people, color contrast is very distinct.Under wood lamp, vitiligo position and surrounding skin have very significantly boundary.Vitiligo can be involved any position of health, and Bilateral Symmetry distributes conventionally.The probability that hair bleaches is 10%-60%.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day, early, middle and late respectively clothes 1 time, 20 days was a course for the treatment of, took continuously 3 courses for the treatment of.
4, efficacy assessment standard
Effective: vitiligo transference cure, it is normal that body constitution is recovered, and observes half a year without recidivist;
Take a turn for the better: vitiligo symptom is clearly better, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy patients with vitiligo 180 examples of the present invention, effective 172 examples of result, obvious effective rate is 95.56%, 6 examples that take a turn for the better, and improvement rate is 3.33%, invalid 2 examples, total effective rate is 98.89%.
Claims (3)
1. treat a leukodermic medicine, it is characterized in that: it is to be made by the crude drug in following weight range:
Rhizoma Chuanxiong 5-15 gram of Fructus Akebiae 10-15 gram of Radix Arnebiae (Radix Lithospermi) 6-15 gram
Herba Artemisiae Anomalae 15-25 gram of Semen Astragali Complanati 10-15 gram of Fructus Leonuri 10-15 gram
Fructus Psoraleae 15-25 gram of Herba Spirodelae 10-15 gram of Radix Achyranthis Bidentatae 6-15 gram
Radix Sanguisorbae 10-15 gram of Fructus Rubi 5-10 gram of Fructus Jujubae 5-15 gram
Fructus Mori 15-25 gram of Semen Persicae 2-8 gram of Radix Curcumae 5-13 gram
Radix Asparagi 5-15 gram of Radix Angelicae Dahuricae 10-15 gram of Herba Ecliptae 10-15 gram
Radix Paeoniae Rubra 5-10 gram of Herba Leonuri 10-20 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
9 grams of 12 grams of Radix Arnebiae (Radix Lithospermi)s of 10 grams of Fructus Akebiaes of Rhizoma Chuanxiong
12 grams of 12 grams of Fructus Leonuris of 20 grams of Semen Astragali Complanatis of Herba Artemisiae Anomalae
9 grams of 12 grams of Radix Achyranthis Bidentataes of 20 grams of Herba Spirodelaes of Fructus Psoraleae
10 grams, 7 grams of Fructus Jujubaes of 12 grams of Fructus Rubies of Radix Sanguisorbae
8 grams of 5 grams of Radix Curcumaes of 20 grams of Semen Persicaes of Fructus Mori
12 grams of 12 grams of Herba Ecliptaes of 10 grams of Radixs Angelicae Dahuricae of Radix Asparagi
15 grams of 7 grams of Herba Leonuris of Radix Paeoniae Rubra.
3. according to the preparation method of medicine described in claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
(2) Fructus Akebiae: clean, slightly soak, moistening is to saturating, and section is dried, or cleans and dry, and the used time smashs to pieces;
(3) Radix Arnebiae (Radix Lithospermi): clean, run through, section, dries;
(4) Herba Artemisiae Anomalae: choose clean impurity, remove root, water edulcoration, slightly soaks, and cutting is dried;
(5) Semen Astragali Complanati: choose decontamination, rinse silt, pull out, dry;
(6) Fructus Leonuri: extract Herb during fruit maturation, dry, lay fruit, choose debranching leaf, well sifted impurity;
(7) Fructus Psoraleae: the most impurity of winnowing with a dustpan, clean, dry;
(8) Herba Spirodelae: 6-9 fishes between the month, dries;
(9) Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
(10) Radix Sanguisorbae: choose decontamination, wash, slightly soak, run through, be cut into sheet, dry;
(11) Fructus Rubi: sieve dedust bits, choose clean impurity, remove handle;
(12) Fructus Jujubae: choose clean impurity, dry;
(13) Fructus Mori: wash, choose decontamination, extract long handle, dry;
(14) Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove kind of a skin, dry, winnow with a dustpan clean;
(15) Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section, dries;
(16) Radix Asparagi: choose decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, dry;
(17) Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;
(18) Herba Ecliptae: choose clean impurity, remove undesirable root, clean vexed, cutting is dried;
(19) Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, cleans, runs through, shave, and dry, sieve removes chip;
(20) Herba Leonuri: choose decontamination, clean, run through, cutting, dries;
(2) preparation
(1) Rhizoma Chuanxiong of described weight, Fructus Akebiae, Radix Arnebiae (Radix Lithospermi), Herba Artemisiae Anomalae, Semen Astragali Complanati, Fructus Leonuri, Fructus Psoraleae, Herba Spirodelae, Radix Achyranthis Bidentatae, Radix Sanguisorbae, Fructus Rubi, Fructus Jujubae, Fructus Mori, Semen Persicae, Radix Curcumae, Radix Asparagi, the Radix Angelicae Dahuricae, Herba Ecliptae, Radix Paeoniae Rubra, Herba Leonuri medicine being added to 6 times of water gagings soaks, soak after 120 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling 20 minutes, decoction liquor is poured in container for the first time again;
(2) add for the second time 3 times of amounts of water, intense fire decocts boiling 10 minutes, then uses slow fire boiling 20 minutes, obtains decoction liquor for the second time;
(3) twice decoction liquor mixed, then simmer in water 10 minutes, decoction liquor is divided into 4 doses and takes.
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| CN103860930B (en) * | 2014-03-19 | 2016-06-01 | 刘凤伟 | The Chinese medicine composition of a kind of effective treatment vitiligo |
| CN103948803A (en) * | 2014-05-13 | 2014-07-30 | 高伦 | Traditional Chinese medicine composition for treating leucoderma |
| CN105833150A (en) * | 2016-05-17 | 2016-08-10 | 商皓 | Externally-applied medicine for treating leucoderma |
| WO2018084671A1 (en) * | 2016-11-04 | 2018-05-11 | 동신대학교산학협력단 | Composition for preventing or treating pigmentation disorders |
| KR101865189B1 (en) * | 2016-11-04 | 2018-06-07 | 동신대학교산학협력단 | Composition for preventing or treating pigmentary disorders caused by hypopigmentation |
| CN106798768A (en) * | 2017-03-06 | 2017-06-06 | 李耀宗 | It is a kind of to treat medicine of leucoderma and preparation method thereof |
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| CN101028362B (en) * | 2007-04-16 | 2010-05-19 | 北京艺信堂医药研究所 | Chinese medicine for treating leucoderma |
| CN101559141A (en) * | 2008-04-17 | 2009-10-21 | 北京汉潮联创中药科技有限公司 | Chinese materia medica preparation for treating vitiligo |
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