CN104491622A - Pharmaceutical composition for treating delayed menstrual cycle - Google Patents
Pharmaceutical composition for treating delayed menstrual cycle Download PDFInfo
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- CN104491622A CN104491622A CN201410818113.2A CN201410818113A CN104491622A CN 104491622 A CN104491622 A CN 104491622A CN 201410818113 A CN201410818113 A CN 201410818113A CN 104491622 A CN104491622 A CN 104491622A
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Abstract
The invention belongs to the technical field of medicines and in particular relates to a pharmaceutical composition for treating delayed menstrual cycle. The pharmaceutical composition comprises the following components: the seed of Chinese dodder, the root of three-nerved spicebush, ligusticum wallichii, rhizoma sparganii, prepared tuber of multiflower knotweed, the root of bidentate achyranthes, prepared rehmannia root, caulis spatholobi, Chinese yam and safflower. The pharmaceutical composition disclosed by the invention refers to Chinese herbal medicines, accords with the medicine indication of the delayed menstrual cycle, particularly delayed menstrual cycle caused by renal deficiency and blood stasis, and is exact in curative effect and suitable for clinical popularization and application.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of pharmaceutical composition for the treatment of delayed menstrual cycle.
Background technology
Menstruation finds expression in outer physiological phenomenon in women's growth promoter, maturation process, is the symbol of fertility.It comes " as tide, monthly once ", if menstruation is lost in normal manner, is then menoxenia.Clinical mainly with menstrual cycle, menstrual period, abnormal for feature through amount, specifically can be divided into preceeded menorrhea, delayed menstrual cycle, irregular menstrual period, menorrhagia, hypomenorrhea, menostaxis, intermenstrual bleeding etc.
Delayed menstrual cycle is common gynecological disease, refers to that menstrual cycle extends, after row mistake more than 7 days, and even 3 ~ 5 months passerbys, continuous two cycle above persons, can belong to the category of western medicine " hypomenorrhea ".Delayed menstrual cycle often merges hypomenorrhea, impact fertility.Do not treat in time, or malpractice, can develop into amenorrhea, sickness rate obviously increases in recent years.The western medicine Pathophysiology more complicated of primary disease, common with the delayed menstrual cycle that polycystic ovarian syndrome (PCOS) causes clinically.Polycystic ovarian syndrome, be the clinical syndrome of menstrual regulation mechanism caused by abnormal, often show as amenorrhea or hypomenorrhea, amenorrhea mostly is Secondary cases, often has hypomenorrhea or very few before amenorrhea.
Doctor trained in Western medicine many employings Estrogen and progestin alternative medicine and promoting ovulation drug treatment, thus adjustment menstrual cycle, ovulation rate.But easily recurrence after hormonal medicaments treatment, after medication, body weight has increases tendency.The traditional Chinese medical science thinks that delayed menstrual cycle is main relevant with liver spleen kidney, and be Liver and kidney asthenia of essence and blood or overstrain impairing the spleen, QI and blood source is not enough, and cause punching and appoint loss, the sea of blood can not as scheduled caused by spill-over.The traditional Chinese medical science is according to deficiency syndrome should be treated by tonifying method, sthenia syndrome requiring purgation, the principle of cold person's using warming therapy carries out Coryza Treated by Syndrome Differentiation, in treatment menoxenia, with a long history, experienced, therefore application treatment by Chinese herbs primary disease is ideal, can treating both the principal and secondary aspects of a disease, determined curative effect, toxic and side effects is little, in the treatment of delayed menstrual cycle, have extensive prospect.
Summary of the invention
The invention provides a kind of new pharmaceutical composition for the treatment of delayed menstrual cycle, this pharmaceutical composition is rapid-action, good effect, toxic and side effects is little, and it is obtained by following raw material: Semen Cuscutae, the Radix Linderae, Rhizoma Chuanxiong, Rhizoma Sparganii, Radix Polygoni Multiflori Preparata, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Caulis Spatholobi, Rhizoma Dioscoreae, Flos Carthami.
The technical scheme adopted for solving its technical problem is the pharmaceutical composition of described treatment delayed menstrual cycle, be made up of the medicine material of following weight: Semen Cuscutae 15-25 part, Radix Linderae 5-11 part, Rhizoma Chuanxiong 15-20 part, Rhizoma Sparganii 5-10 part, Radix Polygoni Multiflori Preparata 15-20 part, Radix Achyranthis Bidentatae 8-16 part, Radix Rehmanniae Preparata 10-20 part, Caulis Spatholobi 15-25 part, Rhizoma Dioscoreae 10-20 part, Flos Carthami 1-5 part.
The preferred technical solution of the present invention is, described pharmaceutical composition of the present invention is obtained by the raw material of following weight portion: Semen Cuscutae 20 parts, the Radix Linderae 8 parts, Rhizoma Chuanxiong 18 parts, Rhizoma Sparganii 8 parts, Radix Polygoni Multiflori Preparata 18 parts, Radix Achyranthis Bidentatae 12 parts, Radix Rehmanniae Preparata 15 parts, Caulis Spatholobi 20 parts, Rhizoma Dioscoreae 15 parts, 3 parts, Flos Carthami.
Present invention also offers the preparation method of described pharmaceutical composition, specifically comprise the steps: after the raw material Semen Cuscutae of above-mentioned weight portion, the Radix Linderae, Rhizoma Chuanxiong, Rhizoma Sparganii, Radix Polygoni Multiflori Preparata, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Caulis Spatholobi, Rhizoma Dioscoreae, Flos Carthami pulverizing, add the soak by water 3 times of medical material gross mass 10 times amount, each 3.5 hours, filter cleaner extracting juice merges, and when the filtrate after merging is concentrated into 65 DEG C, its relative density is the thick paste of 1.12-1.15, to obtain final product.
Those skilled in the art directly can be used as medicine on obtained active constituents of medicine basis of the present invention to use or add on pharmaceutics acceptable adjuvant routinely technique be prepared into required preparation.As the oral drugs of the solid dosage form such as conventional tablet (dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, effervescent tablet), capsule (hard capsule, soft capsule), granule, pill (drop pill), powder can be made, the oral drugs of the liquid forms such as syrup, oral liquid, water preparation, mixture, decoction also can be made.Therefore, in this pharmaceutical composition except effective ingredient, pharmaceutically acceptable adjuvant can also be contained.Preferably, pharmaceutical composition of the present invention conveniently preparation technology be prepared into oral liquid, syrup, capsule or powder etc.
The present invention also asks to protect aforementioned pharmaceutical compositions in the purposes of preparation treatment delayed menstrual cycle particularly in preparation treatment kidney deficiency blood stasis type delayed menstrual cycle medicine.Known by clinical trial, efficacy evaluation result after 2 courses for the treatment of of two groups of patient treatments, treatment group cure rate is 59.09%, matched group cure rate is 32.56%, and treatment group obvious effective rate is 31.82%, and matched group obvious effective rate is 20.93%, treatment group total effective rate is 95.45%, matched group total effective rate is at menstrual cycle, through amount, the improvement all comparatively having highly significant in matter etc. before treatment, treatment group is better than matched group after 74.42%, two groups of patient treatments.In safety evaluatio, the routine blood test before and after treatment group patient consumes, routine urinalysis, electrocardiogram etc. inspections do not find obvious exception.Illustrate that using medicine composite for curing delayed menstrual cycle of the present invention particularly to treat belongs to kidney deficiency blood stasis type delayed menstrual cycle disease determined curative effect thus, serve the remarkable result for the treatment of both the principal and secondary aspects of a disease, safe and reliable, can be used as the effective ways for the treatment of kidney deficiency blood stasis type delayed menstrual cycle disease, be worth of widely use in clinical.
In pharmaceutical composition of the present invention, described Semen Cuscutae, sweet, temperature.Return liver,kidney,spleen warp.Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
The Radix Linderae, pungent, temperature.Return lung, spleen, kidney, urinary bladder channel.Pleasant pain relieving, warming kidney for dispelling cold.For chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia, dysmenorrhea.
Rhizoma Chuanxiong, pungent, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Rhizoma Sparganii, acrid in the mouth; Puckery; Cool.Liver; Spleen channel.Removing blood stasis circulation of qi promoting; Removing food stagnancy pain relieving.Primary symptom abdominal mass mass in the abdomen; The stagnant amenorrhea of the stasis of blood; Dysmenorrhea; Food stagnation distending pain; Fall the year pain of injury.
Radix Polygoni Multiflori Preparata, bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening.For blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body is empty; Hyperlipidemia.
Radix Achyranthis Bidentatae is bitter, sour, flat.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea and mass in the abdomen, dizziness due to hyperactivity of liver-YANG.
Radix Rehmanniae Preparata, sweet, tepor.Return liver, kidney channel.Nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
Caulis Spatholobi, bitter, sweet, temperature.Return liver, kidney channel.Enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Rhizoma Dioscoreae, sweet; Flat.Lung; Spleen; Kidney channel.Spleen reinforcing; Support lung; Reinforce the kidney; Benefit essence.Main diarrhea due to hypofunction of the spleen; Lack of appetite edema; Cough and asthma due to lung deficiency; Quench one's thirst; Seminal emission; Leukorrhagia; To suffer from a deficiency of the kidney frequent micturition; Carbuncle is controlled in external; Scrofula.
Flos Carthami, pungent, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia ， mass in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Pharmaceutical composition of the present invention, for the purpose of invigorating kidney, promoting blood circulation, is selected Semen Cuscutae to have invigorating the liver and kidney benefit essence, is adjusted punching to appoint, the effect of spleen reinforcing kidney yang.Radix Polygoni Multiflori Preparata invigorating the liver and kidney, bone and muscle strengthening.Radix Achyranthis Bidentatae promoting blood circulation to restore menstrual flow, liver and kidney tonifying, property is apt to descending, both invigorating the liver and kidney of use, and also promoting blood circulation to restore menstrual flow again can conducting blood to flow downwards.Radix Rehmanniae Preparata nourishing YIN and benefiting blood, large invigorating the liver and kidney.Effect that Caulis Spatholobi has promoting the circulation of blood to enrich blood.The Radix Linderae, Rhizoma Chuanxiong, Rhizoma Sparganii invigorating kidney, promoting blood circulation, regulating QI to promote menstruation.Chinese yam spleen-strengtheningporridge is reinforced the kidney, and clear and richly promotes the production of body fluid.Flos Carthami promoting blood circulation to remove blood stasis.All medicines are harmonious, and also mend and also lead to, and make QI and blood sufficient, the sea of blood is on time filled, thus effectively treats delayed menstrual cycle particularly kidney deficiency blood stasis type delayed menstrual cycle disease.
Pharmaceutical composition of the present invention is natural pure Chinese medicinal preparation, former medicine is easy to get, with low cost, follow the prescriptions principle of the traditional Chinese medical science, untoward reaction and side effect significantly reduce, safety coefficient is high, through clinical practice checking, its determined curative effect, mild in medicine property and, there is not toxic and side effects and serious adverse reaction, clinical observation total effective rate reaches more than 90%, and dosage form medication prepared by the present invention is simultaneously convenient, improves the compliance of delayed menstrual cycle patient.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
The each raw material of the present invention is taken: Semen Cuscutae 20 parts, the Radix Linderae 8 parts, Rhizoma Chuanxiong 18 parts, Rhizoma Sparganii 8 parts, Radix Polygoni Multiflori Preparata 18 parts, Radix Achyranthis Bidentatae 12 parts, Radix Rehmanniae Preparata 15 parts, Caulis Spatholobi 20 parts, Rhizoma Dioscoreae 15 parts, 3 parts, Flos Carthami by following weight portion.
Preparation technology is as follows: after the raw material chicken Semen Cuscutae of above-mentioned weight portion, the Radix Linderae, Rhizoma Chuanxiong, Rhizoma Sparganii, Radix Polygoni Multiflori Preparata, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Caulis Spatholobi, Rhizoma Dioscoreae, Flos Carthami being pulverized, add the soak by water 3 times of gross mass 10 times amount, each 3.5 hours, filter cleaner extracting juice merges, and when the filtrate after merging is concentrated into 65 DEG C, its relative density is the thick paste of 1.12-1.15, to obtain final product.Those skilled in the art directly can be used as medicine on this basis and be used or add adjuvant conventional formulation technique and obtain the conventional oral formulations such as oral liquid, water preparation, electuary, capsule or powder.
When using medicine composite for curing delayed menstrual cycle of the present invention to demonstrate,prove, take prepared electuary or powder, every bag contains crude drug amount 3g, every day 2 times, each 1 bag.
Embodiment 2
The each raw material of the present invention is taken: Semen Cuscutae 15 parts, the Radix Linderae 5 parts, Rhizoma Chuanxiong 15 parts, Rhizoma Sparganii 5 parts, Radix Polygoni Multiflori Preparata 15 parts, Radix Achyranthis Bidentatae 8 parts, Radix Rehmanniae Preparata 10 parts, Caulis Spatholobi 15 parts, Rhizoma Dioscoreae 10 parts, 1 part, Flos Carthami by following weight portion.
Embodiment 3
The each raw material of the present invention is taken: Semen Cuscutae 25 parts, the Radix Linderae 11 parts, Rhizoma Chuanxiong 20 parts, Rhizoma Sparganii 10 parts, Radix Polygoni Multiflori Preparata 20 parts, Radix Achyranthis Bidentatae 16 parts, Radix Rehmanniae Preparata 20 parts, Caulis Spatholobi 25 parts, Rhizoma Dioscoreae 20 parts, 5 parts, Flos Carthami by following weight portion.
Embodiment 4
The each raw material of the present invention is taken: Semen Cuscutae 15 parts, the Radix Linderae 11 parts, Rhizoma Chuanxiong 20 parts, Rhizoma Sparganii 5 parts, Radix Polygoni Multiflori Preparata 20 parts, Radix Achyranthis Bidentatae 8 parts, Radix Rehmanniae Preparata 20 parts, Caulis Spatholobi 15 parts, Rhizoma Dioscoreae 20 parts, 1 part, Flos Carthami by following weight portion.
Embodiment 5
The each raw material of the present invention is taken: Semen Cuscutae 25 parts, the Radix Linderae 5 parts, Rhizoma Chuanxiong 15 parts, Rhizoma Sparganii 10 parts, Radix Polygoni Multiflori Preparata 15 parts, Radix Achyranthis Bidentatae 16 parts, Radix Rehmanniae Preparata 10 parts, Caulis Spatholobi 25 parts, Rhizoma Dioscoreae 10 parts, 5 parts, Flos Carthami by following weight portion.
The same embodiment 1 of embodiment 2-5.
The clinical observation of embodiment 6 medicine composite for curing delayed menstrual cycle of the present invention
1, case-data: patient 87 example meeting delayed menstrual cycle (blood stasis due to renal deficiency card) diagnostic criteria selecting hospital's Gynecological Ward and outpatient clinic.Take the table of random number method of dividision into groups, selected 87 routine patients are divided into treatment group and matched group, through statistical analysis, two groups of cases there was no significant difference in age, the course of disease, the state of an illness etc., two groups have comparability.
Wherein, treatment group, 44 examples, age 20-35 year, 28.6 years old mean age, menstrual cycle delays 10-20d person 24 example, 30-70d person 20 example, the course of disease the shortest half a year, the longest 3 years.Matched group, 43 examples, age 20-35 year, 28.1 years old mean age, menstrual cycle delays 10-20d person 24 example, 30-70d person 19 example, the course of disease the shortest half a year, the longest 3 years.
All need intramuscular injection Progesterone before most of patients treatment, menstruation just can be risen.All cases all carry out gynecologial examination (unmarried's anus is looked into) and ultrasound diagnosis, do not find pelvic cavity organic disease.
2, diagnosis basis:
1) tcm diagnosis standard
(1) menstrual cycle was more than 35 days, more than continuous 2 menstrual cycle.
(2) women of child-bearing age delay in the cycle, should differentiate mutually with gestation, adolescence, climacteric menstruation later stage.
(3) gynecologial examination, B ultrasonic or pneumoperitoneography, to get rid of uterus and ovary organic disease.
2) TCM syndrome diagnostic criteria: blood stasis due to renal deficiency is demonstrate,proved:
Main symptom: menstruation is delayed, hypomenorrhea, the light or darkness of color has block.
Secondary card: blockage of menstruation or distention and pain in the lower abdomen, spirit is not good enough, or depressed few joyous, lumbocrural pain, dizzy difference of sleeping, complexion ash etc.
Tongue arteries and veins: body of the tongue is light red, thin fur, deep and weak pulse or heavy thin string.
Above main symptom is indispensable, and secondary card 1 ~ 2 adds tongue, arteries and veins and diagnosable.
3) Western medicine diagnose standard: formulate with reference to " disease of tcm diagnosis and treatment standard and prescription are selected " (calendar year 2001).
(1) menstrual cycle is delayed more than more than 7 days, is no more than 3 months, continues more than 2 menstrual cycle.
(2) women of child-bearing age delay in the cycle, should differentiate mutually with early pregnancy.
(3) gynecologial examination: inside and outside genitals is without organic disease.
(4) auxiliary examination:
1. basal body temperature (BBT) measures: basal body temperature two-phase, but follicular phase is long, and high-temperature-phase is on the low side.
2. endometrial biopsy: menstrual period, endometrial secretion was not good enough.
3. endocrine hormone mensuration estrogen level visible postmenstruation continues low, and follicle can not be reached maturity when the time comes and ovulate.
3, inclusive criteria:
(1) age is between 18-45 year;
(2) meet in delayed menstrual cycle, Western medicine diagnose standard and the diagnostic criteria of kidney deficiency blood stasis type TCM syndrome;
(3) the normal person of the past menstrual cycle;
(4) treat in first 3 months and do not use hormone medicine, during Ureteral Calculus, do not take other emmenagogues;
(5) " Informed Consent Form " person is signed.
4, exclusion standard:
(1) " Informed Consent Form " person is not signed.
(2) there is other endocrinopathyes person, as congenital adrenal cortical hyper plasia, hypercortisolism, ovary or adrenal gland neoplasms, abnormal thyroid function, premature ovarian failure, hyperprolactinemia, hyperinsulinemia, diabetes etc.; There are reproductive system or relevant organ organizer matter sexually transmitted disease (STD) change person.
(3) suspicious breast carcinoma or have breast carcinoma medical history person, known tumor, thrombotic disease, the liver function that maybe can be suspected to have estrogen-dependent abnormal.
(4) serious complication: as cardiovascular, liver, kidney, hemopoietic system, nervous system disease.
(5) women in trimester of pregnancy, age of sucking, menarche 1 year.
(6) known maybe may to trial drug and component allergy sufferers thereof.
5, to reject and the standard that comes off:
(1), after case is selected in, find not meet inclusive criteria or meet exclusion standard person;
(2) there is serious adverse events, judge to stop this case clinical trial person according to doctor;
(3) case selected after data not entirely or not by specifying medication person;
(4) in process of the test, experimenter's compliance is poor, and affect the treatment estimator.
6, usage and dosage:
Treatment group: give Drug therapy of the present invention, electuary prepared by Example 1, every bag containing crude drug amount 3g, every day 2 times, each 1 bag, drug withdrawal in menstrual period, through after following the service, serveing on 3 menstrual cycle is 1 course for the treatment of.Efficacy result is evaluated after 2 courses for the treatment of.
Matched group: female clever ball (the accurate word Z21021219 of traditional Chinese medicines), oral, 15 balls, every 10 balls are equivalent to crude drug in whole 2.6g, 2 times on the one.Drug withdrawal in menstrual period, through after following the service, serveing on 3 menstrual cycle is 1 course for the treatment of.Efficacy result is evaluated after 2 courses for the treatment of.
7, efficacy evaluation:
(1) fully recover: menstrual cycle recovers normal, menstrual period, also normal through amount, other cardinal symptoms disappear, and drug withdrawal 3 menstrual cycle do not recur;
(2) effective: menstrual cycle recovers normal, menstrual period, also normal through amount, other cardinal symptoms alleviate, and drug withdrawal 3 menstrual cycle still belong to normal range;
(3) effective: menstrual cycle makes moderate progress, but occasionally delay more than 7 days, other cardinal symptoms alleviate;
(4) invalid: menstrual cycle is without improvement.
9, therapeutic effect:
Without rejecting and the case that comes off in therapeutic process, all complete clinical observation.
Efficacy evaluation result after 2 courses for the treatment of of two groups of patient treatments, treatment group cure rate is 59.09%, matched group cure rate is 32.56%, treatment group obvious effective rate is 31.82%, matched group obvious effective rate is 20.93%, and treatment group total effective rate is 95.45%, and matched group total effective rate is 74.42%, at menstrual cycle, through amount, the improvement all comparatively having highly significant in matter etc. before treatment, treatment group is better than matched group after two groups of treatments.
In safety evaluatio, the routine blood test before and after treatment group patient consumes, routine urinalysis, electrocardiogram etc. inspections do not find obvious exception.Illustrate that using medicine composite for curing delayed menstrual cycle disease of the present invention particularly to treat belongs to kidney deficiency blood stasis type delayed menstrual cycle disease determined curative effect thus, safe and reliable, can be used as the effective ways for the treatment of kidney deficiency blood stasis type delayed menstrual cycle disease, be worth of widely use in clinical.
Claims (8)
1. treat the pharmaceutical composition of delayed menstrual cycle for one kind, it is characterized in that, it obtains primarily of the raw material of following weight portion: Semen Cuscutae 15-25 part, Radix Linderae 5-11 part, Rhizoma Chuanxiong 15-20 part, Rhizoma Sparganii 5-10 part, Radix Polygoni Multiflori Preparata 15-20 part, Radix Achyranthis Bidentatae 8-16 part, Radix Rehmanniae Preparata 10-20 part, Caulis Spatholobi 15-25 part, Rhizoma Dioscoreae 10-20 part, Flos Carthami 1-5 part.
2. pharmaceutical composition as claimed in claim 1, is characterized in that, it obtains primarily of the raw material of following weight portion: Semen Cuscutae 20 parts, the Radix Linderae 8 parts, Rhizoma Chuanxiong 18 parts, Rhizoma Sparganii 8 parts, Radix Polygoni Multiflori Preparata 18 parts, Radix Achyranthis Bidentatae 12 parts, Radix Rehmanniae Preparata 15 parts, Caulis Spatholobi 20 parts, Rhizoma Dioscoreae 15 parts, 3 parts, Flos Carthami.
3. pharmaceutical composition as claimed in claim 1 or 2, it is characterized in that, described pharmaceutical composition is oral formulations.
4. pharmaceutical composition as claimed in claim 3, it is characterized in that, described oral formulations is oral liquid, water preparation, electuary, capsule or powder.
5. pharmaceutical composition as claimed in claim 4, it is characterized in that, described oral formulations is electuary.
6. prepare the method for pharmaceutical composition as claimed in claim 1 or 2 for one kind, it is characterized in that, comprise the steps: after the raw material Semen Cuscutae of above-mentioned weight portion, the Radix Linderae, Rhizoma Chuanxiong, Rhizoma Sparganii, Radix Polygoni Multiflori Preparata, Radix Achyranthis Bidentatae, Radix Rehmanniae Preparata, Caulis Spatholobi, Rhizoma Dioscoreae, Flos Carthami pulverizing, add the soak by water 3 times of medical material gross mass 10 times amount, each 3.5 hours, filter cleaner extracting juice merged, and when the filtrate after merging is concentrated into 65 DEG C, its relative density is the thick paste of 1.12-1.15, to obtain final product.
7. the purposes of pharmaceutical composition as claimed in claim 1 or 2 in preparation treatment delayed menstrual cycle medicine.
8. the purposes of pharmaceutical composition as claimed in claim 1 or 2 in preparation treatment kidney deficiency blood stasis type delayed menstrual cycle medicine.
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| CN104784477A (en) * | 2015-05-05 | 2015-07-22 | 淄博齐鼎立专利信息咨询有限公司 | Traditional Chinese medicine composition for treating delayed menstrual cycle |
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| CN102961644A (en) * | 2012-11-13 | 2013-03-13 | 陈维爱 | Traditional Chinese medicine composition for treating hypomenorrhea |
| CN103735792A (en) * | 2014-01-28 | 2014-04-23 | 张怀胜 | Medicament for treating abnormal menstruation and preparation method for medicament |
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| CN102961644A (en) * | 2012-11-13 | 2013-03-13 | 陈维爱 | Traditional Chinese medicine composition for treating hypomenorrhea |
| CN103735792A (en) * | 2014-01-28 | 2014-04-23 | 张怀胜 | Medicament for treating abnormal menstruation and preparation method for medicament |
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| CN104784477A (en) * | 2015-05-05 | 2015-07-22 | 淄博齐鼎立专利信息咨询有限公司 | Traditional Chinese medicine composition for treating delayed menstrual cycle |
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