CN106728527A - A kind of Chinese medicine preparation for progestogenic after ovulation - Google Patents

A kind of Chinese medicine preparation for progestogenic after ovulation Download PDF

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CN106728527A
CN106728527A CN201710074700.9A CN201710074700A CN106728527A CN 106728527 A CN106728527 A CN 106728527A CN 201710074700 A CN201710074700 A CN 201710074700A CN 106728527 A CN106728527 A CN 106728527A
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root
ovulation
progestogenic
semen
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陶霞霞
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
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Abstract

The present invention relates to a kind of Chinese medicine preparation for progestogenic after ovulation, its technical characteristic is formed by following material combination:10 18 parts of BAIGUFAN, 18 25 parts of raspberry, 20 28 parts of Semen Leonuri, 20 28 parts of amethyst, 18 25 parts of mistletoe, 10 18 parts of HERBA EPIMEDII, 10 18 parts of Semen Cuscutae, 10 18 parts of teasel root, 20 28 parts of astragali, 10 18 parts of semen astragali complanati, the 25g of dried human placenta 18,10 18 parts of mountain Berry root, 18 25 parts of herba lycopi, 10 18 parts of the root of bidentate achyranthes, 10 18 parts of thizoma curculiginis, 18 25 parts of the fruit of Cherokee rose.The present invention has kidney and spleen invigorating, benefiting qi for promoting production of blood, soothing liver-qi stagnation, the effect of eleminating phlegm and freeing channels, and female physiological function is nursed one's health on the whole so as to reach the effect of ovulation progestogenic.Suitable for the Chinese medicine preparation of progestogenic after ovulation.Low cost, treatment time is short, and determined curative effect, cure rate is high, the optimal Chinese medicine preparation for progestogenic after ovulation having no toxic side effect.With good promotional value.

Description

A kind of Chinese medicine preparation for progestogenic after ovulation
Technical field
The present invention relates to a kind of Chinese medicine, specifically a kind of Chinese medicine preparation for progestogenic after ovulation.
Background technology
Ovarian follicle (follicle)OvaryBy one in cortexEgg mother cellAnd it is many small-sized around itFollicle cellConstituted. According to the form and changes of function of Ovarian Follicles, can be divided intoPrimordial follicle, growing follicle andGraaffian follicleThree phases.Female The primordial follicle of property is inherent, and neonate both sides ovary just has 700,000~2,000,000 primordial follicles, be there are about to puberty 40000 primordial follicles.Ultrasonoscopy provides an effective method to detection follicular development and whether ovulation, to follicular development Exception and various ovulation failures can more clearly be diagnosed.Clinically most common exception hasFollicular dysplasiaAnd nothing Follicular development.
The generation of ovarian follicle is developed since primordial follicle.People's each menstrual cycle, usual only one of which primordial follicle was in hormone Regulation and control under reach maturity, primordial follicle through primary follicle and secondary follicular phase, finally development for preovulatory follicle (Mature egg Bubble).The early stage of primary follicle is arrived in primordial follicle development, not by hypophysisPromoting sexual gland hormoneControl, its development depend on ovarian follicle sheet The internal memory factor of body.Late period is developed to primary follicle, fsh receptor is occurred in that on granular cell, occur in that LH is received on endo cell Body.Occur in that fsh receptor quantity further increases to secondary follicular phase, on granular cell, association high effects of the FSH in estrogen Under, there are LH acceptors in induced particle cell, and as follicular development is ripe, and granular cell is continuous with LH acceptors on endo cell Increase.Since the primary follicle stage of development, ovarian follicle receives the control of pituitary gonadotropic hormone, promotes it to reach maturity.
Follicular phase was by last timeMenstruationClosing day starts to ovaryOvulation dayOnly, 10~12 days are lasted.It is interim at this, this phase The granulosa cell of ovarian follicle is produced in the presence of FSH and LHEstrogen, in the presence of estrogen,EndometriumRapid propagation, Blood vessel hyperplasia, the broadening lengthening of body of gland, but do not secrete.This end of term, ovaryOvulation.If after egg maturation, discharge is failed for some reason, Also will be into next phase.
The content of the invention：
In order to solve above-mentioned technical problem, the present invention provides a kind of pregnancy probability that can effectively improve women, improves ovum The Chinese medicine preparation of the follicular phase progestogenic of alveolar substance amount.Low cost, treatment time is short, and determined curative effect, cure rate is high, has no toxic side effect For the optimal Chinese medicine preparation of progestogenic after ovulation.
In order to achieve the above object, the present invention uses following technical scheme：
BAIGUFAN 10-18 parts, raspberry 18-25 parts, Semen Leonuri 20-28 parts, amethyst 20-28 parts, mistletoe 18-25 Part, HERBA EPIMEDII 10-18 parts, Semen Cuscutae 10-18 parts, teasel root 10-18 parts, astragali 20-28 parts, semen astragali complanati 10-18 parts, dried human placenta 10-18 parts, herba lycopi 18-25 parts, root of bidentate achyranthes 10-18 parts, thizoma curculiginis 10-18 parts, fruit of Cherokee rose 18-25 parts of 18-25g, mountain Berry roots.
As preferred, it is made up of following raw material：10 parts of BAIGUFAN, 18 parts of raspberry, 20 parts of Semen Leonuri, 20 parts of amethyst, 18 parts of mistletoe, 10 parts of HERBA EPIMEDII, 10 parts of Semen Cuscutae, 10 parts of teasel root, 20 parts of astragali, 10 parts of semen astragali complanati, 18 parts of dried human placenta, mountain Berry 10 parts of root, 18 parts of herba lycopi, 10 parts of the root of bidentate achyranthes, 10 parts of thizoma curculiginis, 18 parts of the fruit of Cherokee rose.
As preferred, it is made up of following raw material:15 parts of BAIGUFAN, 22 parts of raspberry, 25 parts of Semen Leonuri, amethyst 25 Part, 22 parts of mistletoe, 15 parts of HERBA EPIMEDII, 15 parts of Semen Cuscutae, 15 parts of teasel root, 25 parts of astragali, 15 parts of semen astragali complanati, 22 parts of dried human placenta, 15 parts of mountain Berry root, 22 parts of herba lycopi, 15 parts of the root of bidentate achyranthes, 15 parts of thizoma curculiginis, 22 parts of the fruit of Cherokee rose.
As preferred, it is made up of following raw material:18 parts of BAIGUFAN, 25 parts of raspberry, 28 parts of Semen Leonuri, amethyst 28 Part, 25 parts of mistletoe, 18 parts of HERBA EPIMEDII, 18 parts of Semen Cuscutae, 18 parts of teasel root, 28 parts of astragali, 18 parts of semen astragali complanati, 25 parts of dried human placenta, 18 parts of mountain Berry root, 25 parts of herba lycopi, 18 parts of the root of bidentate achyranthes, 18 parts of thizoma curculiginis, 25 parts of the fruit of Cherokee rose.
Effect of each component in the present invention:
Semen Leonuri：With promoting blood circulation for regulating menstruation, the effect clear liver and improved vision.For irregular menstruation, closed dysmenorrhea, cataract, head Dizzy distending pain.《Compendium of Materia Medica》：Control wind antipyretic, pleasant promoting blood circulation, the nourishing the liver benefit heart, peace soul determines soul, adjust woman's passages through which vital energy circulates, metrorrhagia under band is produced All diseases before tire afterwards.Long term usage makes us having son.
Amethyst：Relieving palpitation；Calm the nerves；Lowering the adverse flow of qi；Warm uterus section category classification calcium compound class.Pharmacological action：There is excited maincenter Nerve, promotes the effect of ovarian secretion.
Mistletoe：There are wind-damp dispelling, filling liver kidney, strengthening the bones and muscles, antiabortive effect, mistletoe has treatment arthralgia pain due to rheumatism, waist and knee acid Soft, fetal irritability, uterine bleeding pass through many, blood leaking in gestation effect.
HERBA EPIMEDII：There is tonifying kidney and strengthening yang；Dispelling wind and eliminating dampness；Effect of strong muscle key bone, HERBA EPIMEDII cures mainly impotence and seminal emission；Void is cold not Educate；Frequent micturition loses Chu；Dyspnea and cough due to deficiency of the kidney；Soreness and weakness of waist and knees；Arthralgia pain due to rheumatism；Hemiplegia；Four limbs are meciless.
Dried human placenta：Nature and flavor are sweet, salty, temperature, enter lung, the heart, kidney channel, there is tonifying kidney and benefiting sperm, the work(of nourishing qi and blood.Feel at ease blood-nourishing, benefit Gas, benefit essence, removing toxic substances etc..Cure mainly deficient, thin thin, hemoptysis asthma, the hot hectic fever due to yin of labor, seminal emission etc..
The fruit of Cherokee rose：Anti-inflammation, astringent sperm contracting urine, relieving diarrhea with astringents, reducing blood lipid.
Beneficial effects of the present invention：
Chinese medicine preparation of the invention has the effect of kidney and spleen invigorating, benefiting qi for promoting production of blood, soothing liver-qi stagnation, eleminating phlegm and freeing channels, from entirety It is upper to nurse one's health female physiological function so as to reach the effect of ovulation progestogenic.The pregnancy probability of women can be effectively improved, ovarian follicle matter is improved The Chinese medicine preparation of the follicular phase progestogenic of amount.Low cost, treatment time is short, and determined curative effect, cure rate is high, and what is had no toxic side effect is used for The optimal Chinese medicine preparation of progestogenic after ovulation.
Specific embodiment
The present invention is further illustrated for specific embodiment:
Embodiment one：10 parts of BAIGUFAN, 18 parts of raspberry, 20 parts of Semen Leonuri, 20 parts of amethyst, 18 parts of mistletoe, celestial spirit 10 parts of spleen, 10 parts of Semen Cuscutae, 10 parts of teasel root, 20 parts of astragali, 10 parts of semen astragali complanati, 18 parts of dried human placenta, 10 parts of mountain Berry root, herba lycopi 18 Part, 10 parts of the root of bidentate achyranthes, 10 parts of thizoma curculiginis, 18 parts of the fruit of Cherokee rose.
Preparation method and step：Take above-mentioned raw materials to clean impurity elimination, dry, be ground into particle, soak 1 hour, insert In multi-function extractor, add water to cook twice.8 times of water of amount of medicinal material are added up for the first time, is decocted 1-1.5 hours, take decocting liquid, filtering Obtain filtrate.Add up 6 times of water of amount of medicinal material for second, decoct 1 hour, take decocting liquid, filter to get filtrate.Filtrate merges twice, heat-sealing In bag, high temperature sterilization, packaging is obtained final product.The decoction for progestogenic after ovulation that the present invention is made is plastic sealed bagged.
Time of Administration：Refer to that the ovulation after follicle maturity is completed after ovulation, between the next menstrual cycle after ovulation Time, if the menstrual cycle is 28 days, ovulation day refers to the 14th day, is after ovulating from the 15th day to the 28th day).Usage and dosage： Every bag of 200ml, orally, once a bag, twice daily, administration time is a course for the treatment of after ovulating twice.
Implementation result：Patient is healed entirely after taking a course for the treatment of.
Embodiment two：15 parts of BAIGUFAN, 22 parts of raspberry, 25 parts of Semen Leonuri, 25 parts of amethyst, 22 parts of mistletoe, celestial spirit 15 parts of spleen, 15 parts of Semen Cuscutae, 15 parts of teasel root, 25 parts of astragali, 15 parts of semen astragali complanati, 22 parts of dried human placenta, 15 parts of mountain Berry root, herba lycopi 22 Part, 15 parts of the root of bidentate achyranthes, 15 parts of thizoma curculiginis, 22 parts of the fruit of Cherokee rose.
Preparation method and step are identical with embodiment one with usage and dosage, Time of Administration.
Implementation result：Patient is healed entirely after taking a course for the treatment of.
Embodiment three：18 parts of BAIGUFAN, 25 parts of raspberry, 28 parts of Semen Leonuri, 28 parts of amethyst, 25 parts of mistletoe, celestial spirit 18 parts of spleen, 18 parts of Semen Cuscutae, 18 parts of teasel root, 28 parts of astragali, 18 parts of semen astragali complanati, 25 parts of dried human placenta, 18 parts of mountain Berry root, herba lycopi 25 Part, 18 parts of the root of bidentate achyranthes, 18 parts of thizoma curculiginis, 25 parts of the fruit of Cherokee rose.
Preparation method and step are identical with embodiment one with usage and dosage, Time of Administration.
Implementation result：Patient is healed entirely after taking a course for the treatment of.
Physical data:
The present inventor carries out clinical observation treatment, treatment group during in July, 2014 to 2 months 2016 to 360 patients 160 and control group 160.Use Chinese medicine of the present invention：Cure 145 people, effective 11 people, invalid 4 people, total cure rate is up to 90.6%.Use Western medicine (Clomifene, HMG, clomiphene etc.)：Cure 99 people, effective 46 people, invalid 15 people, total healing reaches 61.8%.
Prescription curative effect of the present invention treats comparitive study with Western medicine (Clomifene, HMG, clomiphene etc.)：
Helped from Shandong Province Tai'an benevolence with the data in upper table 1 using Western medicine (Clomifene, HMG, clomiphene etc.) and cured Gynaecology of institute, the time is the data for progestogenic after ovulation in July, 2014 to 2 months 2016.
Above observation indicate that, the Chinese medicine preparation curative effect for progestogenic after ovulation of the invention is high, instant effect, without pair make With cure rate is up to more than 90%, and its curative effect is apparently higher than Western medicine (Clomifene, HMG, clomiphene etc.) treatment group.Especially For those obstinates, Relapse rate and the patient strong to Western medicine drug resistance, after taking Chinese medicine of the invention, also Cured.
(2) treatment method:
For the Chinese medicine preparation of progestogenic after ovulation.Every bag of 200ml, orally, once a bag, twice daily, after ovulating twice
Administration time is a course for the treatment of.
(3) efficacy assessment standard:
Cure：Symptom all disappears (B ultrasonic detects follicle maturity, and diameter is in 18--25mm or so).Effectively：Symptom disappearance (B Super detection follicle maturity, diameter is less than 18mm).It is invalid：Before treatment unchanged (ovarian follicle is not developed or without Folliculogenesis).
Typical case
Model case 1：Wang Yuting, female, 26 years old, 3 years unpregnancies of marrying, came the present inventor clinic in October, 2014, take With Chinese medicine preparation of the invention, fully recovered after a course for the treatment of.(being paid a return visit after half a year, be pregnant with Second Year April)
Model case 2：Liu little Qing, female, 30 years old, be a supervisor for enterprise.Due to an accidental abortion before 2 years, lead Cause not to be pregnant so far, in July, 2015, introduced through friend and come the present inventor clinic, this Chinese medicine preparation has been taken, after a course for the treatment of Recovery from illness.(being paid a return visit after half a year, be pregnant)
Model case 3：Wu Qi, female, 28 years old, be a grade teacher.2 years unpregnancies of marriage, in January, 2016, find this hair A person of good sense, illustrates situation, after taken this invention Chinese medicine, preparation after a course for the treatment of is fully recovered after one course for the treatment of.(paid a return visit after 1 year, A boy is given birth to)

Claims (4)

1. a kind of Chinese medicine preparation for for progestogenic after ovulation, its technical characteristic is formed by following material combination:BAIGUFAN 10-18 parts, raspberry 18-25 parts, Semen Leonuri 20-28 parts, amethyst 20-28 parts, mistletoe 18-25 parts, HERBA EPIMEDII 10-18 Part, Semen Cuscutae 10-18 parts, teasel root 10-18 parts, astragali 20-28 parts, semen astragali complanati 10-18 parts, dried human placenta 18-25g, mountain Berry roots 10- 18 parts, herba lycopi 18-25 parts, root of bidentate achyranthes 10-18 parts, thizoma curculiginis 10-18 parts, fruit of Cherokee rose 18-25 parts.
2. a kind of Chinese medicine preparation for for progestogenic after ovulation according to claim 1, its technical characteristic is by following Material combination is formed:10 parts of BAIGUFAN, 18 parts of raspberry, 20 parts of Semen Leonuri, 20 parts of amethyst, 18 parts of mistletoe, HERBA EPIMEDII 10 Part, 10 parts of Semen Cuscutae, 10 parts of teasel root, 20 parts of astragali, 10 parts of semen astragali complanati, 18 parts of dried human placenta, 10 parts of mountain Berry root, 18 parts of herba lycopi, 10 parts of the root of bidentate achyranthes, 10 parts of thizoma curculiginis, 18 parts of the fruit of Cherokee rose.
3. a kind of Chinese medicine preparation for progestogenic after ovulation according to claim 1, its technical characteristic is by following raw material Combine:15 parts of BAIGUFAN, 22 parts of raspberry, 25 parts of Semen Leonuri, 25 parts of amethyst, 22 parts of mistletoe, 15 parts of HERBA EPIMEDII, Tu 15 parts of silk, 15 parts of teasel root, 25 parts of astragali, 15 parts of semen astragali complanati, 22 parts of dried human placenta, 15 parts of mountain Berry root, 22 parts of herba lycopi, the root of bidentate achyranthes 15 Part, 15 parts of thizoma curculiginis, 22 parts of the fruit of Cherokee rose.
4. a kind of Chinese medicine preparation for for progestogenic after ovulation according to claim 1, its technical characteristic is by following Material combination is formed:18 parts of BAIGUFAN, 25 parts of raspberry, 28 parts of Semen Leonuri, 28 parts of amethyst, 25 parts of mistletoe, HERBA EPIMEDII 18 Part, 18 parts of Semen Cuscutae, 18 parts of teasel root, 28 parts of astragali, 18 parts of semen astragali complanati, 25 parts of dried human placenta, 18 parts of mountain Berry root, 25 parts of herba lycopi, 18 parts of the root of bidentate achyranthes, 18 parts of thizoma curculiginis, 25 parts of the fruit of Cherokee rose.
CN201710074700.9A 2017-02-11 2017-02-11 A kind of Chinese medicine preparation for progestogenic after ovulation Pending CN106728527A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1628840A (en) * 2004-08-17 2005-06-22 石春荣 Medicine for promoting ovulation and aiding pregnancy

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Publication number Priority date Publication date Assignee Title
CN1628840A (en) * 2004-08-17 2005-06-22 石春荣 Medicine for promoting ovulation and aiding pregnancy

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Application publication date: 20170531