CN105311396A - Traditional Chinese medicine preparation for treating hypomenorrhea caused by thin endometrium - Google Patents
Traditional Chinese medicine preparation for treating hypomenorrhea caused by thin endometrium Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine preparation, relates to a medicine for treating irregular menstruation, and particularly relates to a traditional Chinese medicine preparation for treating hypomenorrhea caused by thin endometrium. The preparation is prepared from the following medicinal raw materials in a certain weight ratio: gymnadenia conopsea, manyprickle acanthopanax root, radix rehmanniae praeparata, rhizoma cyperi, radix paeoniae alba, astragalus membranaceus, angelica sinensis, herba lycopi, herba leonuri and ludwigia repens. The traditional Chinese medicine preparation has the effects of invigorating kidney, nourishing essence, benefiting qi for promoting granulation, promoting blood circulation to remove stasis and nourishing blood to regulate menstruation, and is used for strengthening middle warmer with purging, reinforcing yang from yin and nourishing yin and yang progressively to achieve the multi-target, multi-step and multi-level comprehensive regulating effect, so that ovary functions can be improved, microcirculation and growth and repairing of endometrium can be promoted. The traditional Chinese medicine preparation has a relatively small side effect and good patient compliance, is convenient to take, can be used for effectively relieving economic burden and pains of patients to achieve the aim of treating both symptoms and root causes, and is worthy of clinically wide popularization and application.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to the medicine for the treatment of menoxenia, particularly relate to and a kind ofly treat the thin Chinese medicine preparation causing hypomenorrhea of endometrium.
Background technology
Hypomenorrhea refers to that menstrual cycle is normal, and menstrual blood volume is comparatively constant minimizing obviously, or the deficiency of time 2d that passes through, even drop and clean person, and occurs that 2 above persons of menstrual cycle are called " hypomenorrhea " continuously.It is generally acknowledged Hypomenorrhea in 20mL be hypomenorrhea.Hypomenorrhea often can develop into amenorrhea, causes infertile and premature ovarian failure etc., the health of serious threat women, spirit and mental health.
Modern study shows that the pathogenic factor of hypomenorrhea mainly contains the factors such as uterine hypoplasia, endometritis, endometrial tuberculosis; The Ovarian factors such as premature ovarian failure or pure gonadal hypoplasia; Hypothalamus gonadotropin releasing hormone or pituitary gonadotropic hormone secretion decline or imbalance; Artificial abortion dilatation and curettage of uterine excessively or uterine cavity electrocautery etc., has damaged endometrial basal layer or has caused uterine cavity to be adhered; Long-term taking some drugs, as oral contraceptive also can cause hypomenorrhea, very then amenorrhea.
Doctor trained in Western medicine think miscarriage uterine curettage after scrape owing to excessively scratching, cause uterus basal layer inner film injury, endometrium is thinning, causes hypomenorrhea.The number of endometrium thickness to menstrual blood volume has an impact, modern medicine, can patient uterine internal film tissue situation directly perceived by Vagina supersonic inspection method, can be set up the menstrual cycle of rule by estrogen and progestogen sequential therapy, repair endometrium, increase menstrual blood volume.And due to estrogenic side effect make many patients fear use.
Chinese medicine think menstrual onset main have with kidney, menses, punching are appointed, uterus etc. be closely connected, kidney be human body reproduction this, be also the source of menstruation.Deficiency of kidney-essence, no resource of generating and transforming QI and blood, sea of blood virtual loss, punching appoint the vessels of the uterus stasis of blood stagnant, cause Hypomenorrhea.As QI and blood is sufficient, run unimpeded, then punching appoints the sea of blood naturally full, therefore recovers normal through amount, menstruation self-regulated.Endometrium thickness is considered to the one performance whether uterus QI and blood fills, and endometrium is partially thin, then Hypomenorrhea, otherwise then menstrual blood volume is normal.At present, often toxic and side effects is comparatively large for existing western medical treatment clinically, and easily recurs after drug withdrawal, and therapeutic effect is unsatisfactory, and people usually seek help from Chinese medicine.
Summary of the invention
Inventor combines theory and the clinical experience of oneself of the sage of the past at all times, by modern physiological pathology and pathogen and pathology of tcm, dialectically to combine with differential diagnosis of diseases, provide and a kind ofly treat the thin Chinese medicine preparation causing hypomenorrhea of endometrium, it has the kidney invigorating and essence nourishing, benefiting qi for promoting granulation, blood circulation promoting and blood stasis dispelling, the effect of nourishing blood for regulating menstruation, can improve ovarian function, promote microcirculation, endometrial growth, reparation, evident in efficacy.
For achieving the above object, the technical solution used in the present invention is:
Treat the thin Chinese medicine preparation causing hypomenorrhea of endometrium, it is characterized in that by Rhizoma Gymnadeniae, Radix Et Caulis Acanthopanacis Senticosi, Radix Rehmanniae Preparata, Rhizoma Cyperi, the Radix Paeoniae Alba, the Radix Astragali, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri, Radix Phyllagathis fordii be medicinal raw material elaborate.
In order to increase the synergism of effective active composition, inventor, in conjunction with modern Chinese medicine theory of development, from improving curative effect of medication, reducing the angle of side effect, carries out screening to Chinese medicine ingredients and extracts and prescription test, optimize following technical scheme further:
Treat the thin Chinese medicine preparation causing hypomenorrhea of endometrium, it is characterized in that by the raw material elaborate of following weight: Rhizoma Gymnadeniae 18-24 part, Radix Rehmanniae Preparata 13-18 part, Radix Et Caulis Acanthopanacis Senticosi 10-15 part, Radix Astragali 13-18 part, Radix Angelicae Sinensis 10-15 part, Rhizoma Cyperi 7-12 part, Radix Paeoniae Alba 6-9 part, Herba Lycopi 11-16 part, Herba Leonuri 14-18 part, Radix Phyllagathis fordii 15-20 part.
Further preferably, treat the thin Chinese medicine preparation causing hypomenorrhea of endometrium, it is characterized in that by the raw material elaborate of following weight: Rhizoma Gymnadeniae 20 parts, Radix Rehmanniae Preparata 15 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Cyperi 9 parts, the Radix Paeoniae Alba 8 parts, Herba Lycopi 15 parts, Herba Leonuri 15 parts, Radix Phyllagathis fordii 18 parts.
Inventor sums up and thinks the many simulataneous insufficiency and excessive of the cause of disease of Hypomenorrhea after abortion, and deficiency of qi and blood and blood stasis stagnate, deficiency of qi and blood, and it is the main pathogenesis of Hypomenorrhea post-abortion that punching is appointed impaired.Therefore with Rhizoma Gymnadeniae, Radix Et Caulis Acanthopanacis Senticosi, Radix Rehmanniae Preparata, Rhizoma Cyperi, the Radix Paeoniae Alba, the Radix Astragali, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri, Radix Phyllagathis fordii for medicine.Fang Zhong: the sweet temperature of Radix Rehmanniae Preparata, nourishing YIN and supplementing blood, beneficial essence fills out marrow, liver and kidney tonifying; Rhizoma Gymnadeniae is sweet flat, and kidney and spleen invigorating, regulates the flow of vital energy and blood, and the energy invigorating the liver and kidney of two medicines 5, benefiting essence-blood, and taste, blood of regulating the flow of vital energy is monarch drug.The pungent temperature of Radix Et Caulis Acanthopanacis Senticosi is supporing yang, invigorating the spleen and benefiting QI, fills out marrow, replenishing kidney, strengthening waist, promoting blood circulation to remove obstruction in the collateral with Radix Rehmanniae Preparata 5 treating YANG within YIN with beneficial essence.The sweet temperature of the Radix Astragali, invigorating QI to consolidate the body surface resistance, expelling pus and promoting granulation, Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, and two medicines 5 are with supporting nutrition blood, QI invigorating spermatogenesis, and invigorating middle warmer has, and have benefit in row, tool is ministerial drug.Herba Lycopi's toil tepor, enter the logical nutrient blood of liver temperature, blood circulation promoting and blood stasis dispelling, enters the capable water of spleen, can lead to nine orifices, can break dyspepsia, can adjust menstruation, and energy eliminating mass abdominal mass, can swell by aproll, throws, then have benefit in disappearing with the taste of rich in nutrition is same; Herba Leonuri toil is slightly cold, and enters blood system, and property benefaction is walked, and can promoting the circulation of blood stimulate the menstrual flow, and repercussive is by stagnant, and two medicine compatibilities, a Wen Yihan, all kind blood circulation promoting and blood stasis dispelling, passes through and promote blood circulation.Radix Paeoniae Alba picric acid is slightly cold, and energy suppressing the hyperactive liver yin fluid astringing, nourishing blood for regulating menstruation, Radix Phyllagathis fordii is bitter sweet cool, and nourishing blood for regulating menstruation, can help the temperature of monarch drug, and nourishing the liver blood is liver use again, Rhizoma Cyperi promoting QI circulation for relieving depression, menstruction regulating and pain relieving, QI and blood regulating, is adjuvant drug.All medicines close 5, refinforce each other, have the kidney invigorating and essence nourishing, benefiting qi for promoting granulation, blood circulation promoting and blood stasis dispelling, the effect of nourishing blood for regulating menstruation.Uterus blood supply can be made to increase by crossing improvement microcirculation, improving the function of ovary, strengthening the endometrial receptivity of inner membrance, the endometrium of secretory phase can be made to increase, promoting the growth of inner membrance.
The pharmacological property of each herbal medicine of the present invention is as follows:
Rhizoma Gymnadeniae: [nature and flavor] are sweet; Flat.[return through] lung; Spleen; Stomach warp.[function cures mainly] relieving cough and asthma; Yishen Jianpi; Regulate the flow of vital energy and blood; Pain relieving.Main cough and asthma due to lung deficiency; Asthenia is become thin; Neurasthenia; Suffer from a deficiency of the kidney lassitude loin and legs; Sexual impotence; Spermatorrhea; Frequent micturition; Chronic hepatitis; Chronic diarrhea; Lose blood; Leukorrhagia; Breast is few; Traumatic injury.
Radix Et Caulis Acanthopanacis Senticosi: [nature and flavor] pungent, micro-hardship, temperature.[return through] returns spleen, kidney, heart channel.[function cures mainly] replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.
Radix Rehmanniae Preparata: [nature and flavor] are sweet, tepor.[return through] returns liver, kidney channel.[function cures mainly] nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
Rhizoma Cyperi: [nature and flavor] pungent, micro-hardship, micro-sweet, flat.[return through] returns liver, spleen, tri-jiao channel.[function cures mainly] promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
The Radix Paeoniae Alba: [nature and flavor] are bitter, sour, are slightly cold.[return through] returns liver, spleen channel.The pain relieving of [function cures mainly] suppressing the hyperactive liver, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
The Radix Astragali: [nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix Angelicae Sinensis: [nature and flavor] sweet in the mouth; Pungent; Bitter; Warm in nature.[return through] returns liver; The heart; Spleen channel.[function cures mainly] enriches blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down." book on Chinese herbal medicine just ": Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, and have benefit, the gas medicine in sincere blood in row, the panacea also in blood also.
Herba Lycopi: [nature and flavor] bitter in the mouth; Pungent; Slightly warm in nature.[return through] returns liver; Spleen channel.[function cures mainly] blood circulation promoting and blood stasis dispelling; Line water detumescence; Removing toxicity for eliminating carbuncles.Housewife female's amenorrhea; Dysmenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen edema; Traumatic injury; Carbuncle sore tumefacting virus." Bencao Jingshu ": Herba Lycopi, hardship can expel the heat-evil, sweet energy and blood, and acid can enter liver, the logical nutrient blood of temperature.Assistant with the medicine of strengthening the spleen soil, and makes with Radix Stephaniae Tetrandrae, then main extensive abdominal edema, body face extremity edema, aqueous vapor in joint for it.
Herba Leonuri: [nature and flavor] are bitter, pungent, are slightly cold.[return through] returns liver, pericardium channel.[function cures mainly] promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema." detailed outline ": " invigorate blood circulation, removing blood stasis, regulating menstruation, removing toxic substances.Control vaginal bleeding during pregnancy dystocia, placenta retention, bruise, blood wind, blood pain, metrorrhagia and metrostaxis, hematuria, rushes down blood, dysentery, infantile malnutrition, haemorrhoids, beats and flutters interior damage blood stasis, stool, urinary obstruction.”
Radix Phyllagathis fordii: [nature and flavor] mildly bitter flavor; Sweet; Cool in nature.[return through] returns liver; The heart; Urinary bladder channel.[function cures mainly] nourishing blood for regulating menstruation.Main blood deficiency and yellow complexion; Menoxenia; Amenorrhea; Dysmenorrhea; Leukorrhagia.
Chinese medicine preparation described above is that the Rhizoma Gymnadeniae in above-mentioned prescription, Radix Et Caulis Acanthopanacis Senticosi, Radix Rehmanniae Preparata, Rhizoma Cyperi, the Radix Paeoniae Alba, the Radix Astragali, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri, Radix Phyllagathis fordii are extracted effective ingredient as active ingredient according to certain weight using proper method, this composition is independent or mix with medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to galenic pharmacy routine techniques.
Preferably, the preparation method of Chinese medicine preparation described above, it comprises the following steps:
(1) Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri are pulverized, with 65-70% alcohol reflux 3 times, merge 3 extracting solution, concentrating under reduced pressure obtains rare extractum, upper polyamide column, 90% ethanol elution is used again after first colourless to effluent with 20% ethanol elution, collect ethanol elution, decompression recycling ethanol, to without alcohol taste, continues to be concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine;
(2) by Rhizoma Gymnadeniae, Radix Rehmanniae Preparata, Rhizoma Cyperi, the Radix Paeoniae Alba, the Radix Astragali, Radix Phyllagathis fordii and Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri second is extracted rear filtering residue and is decocted with water secondary, first time add water into medical material weight portion 4-10 doubly, decoct 1.0-1.5 hour, second time adds water as the 3-8 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.03-1.08 (60 DEG C record), adding ethanol makes alcohol content reach 55-60% (preferably 55%), leave standstill 12 hours, filter, filtrate recycling ethanol, be concentrated into extractum, lyophilization, obtain the dry cream of Chinese medicine,
Mix homogeneously after (1) is broken with the Chinese medicine dried cream powder of (2) gained, this composition is independent or mix with medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to galenic pharmacy routine techniques.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.
Further preferably, Chinese medicine preparation of the present invention is peroral dosage form, as: soft capsule, capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum.
Further preferably.Chinese medicine preparation of the present invention is tablet, capsule or granule, most preferably capsule.
Chinese medicine preparation of the present invention is in use according to the situation determination usage and dosage of patient.Chinese medicine preparation of the present invention according to the situation determination usage and dosage of patient, can take 1-3 time in use every day, each 1-20 agent, as: 1-20 bag or grain or sheet.
The present invention be inventor through repeatedly studying, progressively improve, the good Chinese medicine preparation of last successful a kind of curative effect, and demonstrated the curative effect of Chinese medicine preparation of the present invention by clinical case further, particulars is as described below:
1 data and method
1.1 physical data: 108 examples are that in May ,-2014 in March, 2013, my Out-patient Department was gone to a doctor post-abortion Hypomenorrhea patient.Matched group and treatment group is divided into according to random digits table.22 ~ 40 years old treatment group age, average (27.6 ± 3.72) year, menstrual blood volume (10.58 ± 1.96) mL, inner film thickness (6.22 ± 0.97) mm; 24 ~ 39 years old matched group age, average (27.2 ± 3.45) year, menstrual blood volume (10.40 ± 2.64) mL, inner film thickness (6.24 ± 1.01) mm.Two groups of patient ages, menstrual blood volume and inner film thickness compare, the equal not statistically significant of difference (P > 0.05).
1.2 diagnostic criterias: " the Gynecology of Chinese Medicine " (China Medical Science Press of writing with reference to Zhang Yuzhen, 2007) and " new Chinese medicine guideline of clinical investigations " draft: (1) clinical manifestation: menstrual cycle rule, basal body temperature (BBT) two-phase has ovulation, and the megathermal period was more than 12 days; Menstrual blood volume is comparatively front reduces 30%, or total amount is less than 20mL; (2) medical history: have artificial abortion operation history or inevitable abortion uterine curettage history; (3) hysteroscope gets rid of intrauterine adhesion; (4) Endocrinological inspection has ovulation, gets rid of hyperprolactinemia and abnormal thyroid function; (5) the B ultrasonic display inner film thickness < 8mm onset of ovulation.
1.3 include in and accord with exclusion standard: include in and meet diagnostic criteria; Treat and do not use Drug therapy person in first 1 month; Informed consent, enters group voluntarily.Get rid of irritated or irritated to medicine to multi-medicament; Merge the substantive disease of the gynecological such as hysteromyoma, ovarian tumor and the person that has surgical indication; Be associated with the serious medical diseases such as cardiovascular, liver, kidney and hemopoietic system; Be associated with nerve, mental disease or be reluctant partner; Recent application crosses similar drugs treatment, thus makes curative effect of medication be difficult to judgement person.
1.4 Therapeutic Method: treatment group adopts simple treatment by Chinese herbs, use capsule prepared by the embodiment of the present invention 1, and 2-4 grain, when taking to menstrual onset, subtracted clothes or withdrew, being a course for the treatment of, taking 3 months continuously with 3 months every day.
Matched group adopts estrogen and progestogen associating sequential therapy, oral estradiol valerate tablet (1mg/ grain, Bayer HealthCare Co), each 2mg, and every day 2 times, menstruation starts to take on the 5th day; Add dydrogesterone sheet after ovulation, each 10mg, every day 2 times, take 10 days.Treat 3 months.
1.5 observation index: (menstrual blood volume estimation adopts the estimation algorithm of cotton wool wetted area to observe menstrual blood volume before and after treatment, for reducing the subjective factors in objective evaluation as far as possible, reduce the error of estimation, the cotton wool of the same brand of unified payment and model as far as possible), time in menstrual period and menstrual cycle 24d endometrium thickness (B ultrasonic monitoring).
1.6 curative effect determinate standards are drafted according to " disease of tcm Standardization of diagnosis and curative effect ".Cure: after drug withdrawal, menstrual blood volume returns to previously menstrual blood volume; Effective: after drug withdrawal, menstrual blood volume obviously increases, reach more than 2/3 of previously menstrual blood volume; Take a turn for the better: after drug withdrawal, menstrual blood volume increases, reach the 1/3-2/3 of previously menstrual blood volume; Invalid: menstrual blood volume without increase, or is still less than 1/3 of previously menstrual blood volume.
1.7 statistical methods: adopt SPSS16.0 statistical software to calculate.Each numerical value with
represent, measurement data adopts t inspection, and enumeration data adopts χ
2inspection, with P < 0.05 for difference has statistical significance.
2 results
2.1 liang of group patient comparitive study: above-mentioned 108 examples are suffered from and are divided into matched group and treatment group according to random digits table, often organize 54 examples, after treatment, treatment group cures 18 examples, effective 22 examples, and take a turn for the better 13 examples, invalid 1 example, obvious effective rate 74.1%, total effective rate 98.1%; Matched group cures 10 examples, effective 13 examples, take a turn for the better 15 examples, do not heal 16 examples, obvious effective rate 42.6%, total effective rate 70.4%, treatment group compares with matched group obvious effective rate, total effective rate, and difference has statistical significance (being respectively P < 0.01 and P < 0.05).In table 1.
Table 1 liang group patient comparitive study (n%, example)
Note: compare with matched group, * P < 0.05, * * P < 0.01.
Before and after 2.2 treatments, endometrium thickness and time in menstrual period compare: after treatment two groups menstrual period time lengthening, there is statistical significance (P < 0.01) the average time in menstrual period with the front comparing difference for the treatment of, compare between two groups after treatment, no significant difference.Treatment endometrium thickness rear luteal phase more also thickens with before treatment, difference has statistical significance (P < 0.01), compare between two groups after treatment, difference has statistical significance (P < 0.05), and treatment group effect is more excellent.In table 2.
Front and back endometrium thickness treated by table 2 and the time in menstrual period compares
Note: compare with before treatment, * P < 0.05, * * P < 0.01; Compare with matched group after treatment,
#p < 0.05.
The observation of adverse effect during 2.3 medications: all do not occur untoward reaction during matched group patient medication.16 routine patients are had to occur slight gastrointestinal reaction during matched group patient medication, as 6 examples of feeling sick, vomiting 5 example, upper abdomen dull pain 4 example; Have 2 routine patients to occur irregular colporrhagia, treatment group compares with matched group, and difference has statistical significance, and treatment group less adverse effect, patient compliance is better.
In a word, compared with prior art, the present invention has following beneficial effect:
Selected by invention medicine, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, comprehensively, medication is thoughtful in legislation, play the kidney invigorating and essence nourishing, benefiting qi for promoting granulation altogether, blood circulation promoting and blood stasis dispelling, the merit of nourishing blood for regulating menstruation, invigorating middle warmer have rush down, treating YANG within YIN, tonifying both YIN and YANG, incremental, play Chinese medicine preparation Mutiple Targets of the present invention, too many levels, multi-level comprehensive regulation effect, can ovarian function be improved, promote microcirculation, endometrial growth, reparation, evident in efficacy.Chinese medicine preparation side effect of the present invention is less, and patient compliance is better, and taking convenience, can effectively alleviate patient's burden and misery, can reach the object for the treatment of both the principal and secondary aspects of a disease, wide popularization and application on clinic.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Prescription: Rhizoma Gymnadeniae 20 parts, Radix Rehmanniae Preparata 15 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Cyperi 9 parts, the Radix Paeoniae Alba 8 parts, Herba Lycopi 15 parts, Herba Leonuri 15 parts, Radix Phyllagathis fordii 18 parts.
Preparation method: Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri are pulverized by (1), with 65% alcohol reflux 3 times, merge 3 extracting solution, concentrating under reduced pressure obtains rare extractum, upper polyamide column, 90% ethanol elution is used again after first colourless to effluent with 20% ethanol elution, collect ethanol elution, decompression recycling ethanol, to without alcohol taste, continues to be concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine;
(2) after Rhizoma Gymnadeniae, Radix Rehmanniae Preparata, Rhizoma Cyperi, the Radix Paeoniae Alba, the Radix Astragali, Radix Phyllagathis fordii and Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri second being extracted, filtering residue decocts with water secondary, first time add water into medical material weight portion 4-10 doubly, decoct 1.0-1.5 hour, second time adds water as the 3-8 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05 (60 DEG C record), adding ethanol makes alcohol content reach 55%, leaves standstill 12 hours, filters, filtrate recycling ethanol, be concentrated into extractum, lyophilization, obtain the dry cream of Chinese medicine;
Mix homogeneously after (1) is broken with the Chinese medicine dried cream powder of (2) gained, make capsule according to galenic pharmacy routine techniques, every is equivalent to crude drug 1.38g.
Embodiment 2
Prescription: Rhizoma Gymnadeniae 20 parts, Radix Rehmanniae Preparata 15 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Cyperi 9 parts, the Radix Paeoniae Alba 8 parts, Herba Lycopi 15 parts, Herba Leonuri 15 parts, Radix Phyllagathis fordii 18 parts.
Preparation method: Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri are pulverized by (1), with 67% alcohol reflux 3 times, merge 3 extracting solution, concentrating under reduced pressure obtains rare extractum, upper polyamide column, 90% ethanol elution is used again after first colourless to effluent with 20% ethanol elution, collect ethanol elution, decompression recycling ethanol, to without alcohol taste, continues to be concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine;
(2) after Rhizoma Gymnadeniae, Radix Rehmanniae Preparata, Rhizoma Cyperi, the Radix Paeoniae Alba, the Radix Astragali, Radix Phyllagathis fordii and Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri second being extracted, filtering residue decocts with water secondary, first time add water into medical material weight portion 4-10 doubly, decoct 1.0-1.5 hour, second time adds water as the 3-8 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.07 (60 DEG C record), adding ethanol makes alcohol content reach 57%, leaves standstill 12 hours, filters, filtrate recycling ethanol, be concentrated into extractum, lyophilization, obtain the dry cream of Chinese medicine;
Mix homogeneously after (1) is broken with the Chinese medicine dried cream powder of (2) gained, make capsule according to galenic pharmacy routine techniques.
Embodiment 3
Prescription: Rhizoma Gymnadeniae 20 parts, Radix Rehmanniae Preparata 15 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Cyperi 9 parts, the Radix Paeoniae Alba 8 parts, Herba Lycopi 15 parts, Herba Leonuri 15 parts, Radix Phyllagathis fordii 18 parts.
Preparation method: Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri are pulverized by (1), with 70% alcohol reflux 3 times, merge 3 extracting solution, concentrating under reduced pressure obtains rare extractum, upper polyamide column, 90% ethanol elution is used again after first colourless to effluent with 20% ethanol elution, collect ethanol elution, decompression recycling ethanol, to without alcohol taste, continues to be concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine;
(2) after Rhizoma Gymnadeniae, Radix Rehmanniae Preparata, Rhizoma Cyperi, the Radix Paeoniae Alba, the Radix Astragali, Radix Phyllagathis fordii and Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri second being extracted, filtering residue decocts with water secondary, first time add water into medical material weight portion 4-10 doubly, decoct 1.0-1.5 hour, second time adds water as the 3-8 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.04 (60 DEG C record), adding ethanol makes alcohol content reach 60%, leaves standstill 12 hours, filters, filtrate recycling ethanol, be concentrated into extractum, lyophilization, obtain the dry cream of Chinese medicine;
Mix homogeneously after (1) is broken with the Chinese medicine dried cream powder of (2) gained, make capsule according to galenic pharmacy routine techniques.
Embodiment 4
Prescription: Rhizoma Gymnadeniae 18 parts, Radix Rehmanniae Preparata 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, the Radix Astragali 13 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Cyperi 10 parts, the Radix Paeoniae Alba 6 parts, Herba Lycopi 12 parts, Herba Leonuri 15 parts, Radix Phyllagathis fordii 20 parts.
Preparation method: the operation with reference to embodiment 1-3 is carried out.
Embodiment 5
Prescription: Rhizoma Gymnadeniae 20 parts, Radix Rehmanniae Preparata 18 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, the Radix Astragali 13 parts, Radix Angelicae Sinensis 13 parts, Rhizoma Cyperi 10 parts, the Radix Paeoniae Alba 7 parts, Herba Lycopi 15 parts, Herba Leonuri 18 parts, Radix Phyllagathis fordii 15 parts.
Preparation method: the operation with reference to embodiment 1-3 is carried out.
Embodiment 6
Prescription: Rhizoma Gymnadeniae 24 parts, Radix Rehmanniae Preparata 18 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Cyperi 12 parts, the Radix Paeoniae Alba 6 parts, Herba Lycopi 11 parts, Herba Leonuri 16 parts, Radix Phyllagathis fordii 15 parts.
Preparation method: the operation with reference to embodiment 1-3 is carried out.
Embodiment 7
Prescription: Rhizoma Gymnadeniae 22 parts, Radix Rehmanniae Preparata 16 parts, Radix Et Caulis Acanthopanacis Senticosi 14 parts, the Radix Astragali 13 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Cyperi 12 parts, the Radix Paeoniae Alba 9 parts, Herba Lycopi 16 parts, Herba Leonuri 16 parts, Radix Phyllagathis fordii 18 parts.
Preparation method: the operation with reference to embodiment 1-3 is carried out.
Embodiment 8
Prescription: Rhizoma Gymnadeniae 20 parts, Radix Rehmanniae Preparata 16 parts, Radix Et Caulis Acanthopanacis Senticosi 13 parts, the Radix Astragali 16 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Cyperi 12 parts, the Radix Paeoniae Alba 9 parts, Herba Lycopi 12 parts, Herba Leonuri 14 parts, Radix Phyllagathis fordii 18 parts.
Preparation method: the operation with reference to embodiment 1-3 is carried out.
Embodiment 9
Prescription: Rhizoma Gymnadeniae 20 parts, Radix Rehmanniae Preparata 15 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Cyperi 9 parts, the Radix Paeoniae Alba 8 parts, Herba Lycopi 15 parts, Herba Leonuri 15 parts, Radix Phyllagathis fordii 18 parts.
Preparation method: Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri are pulverized by (1), with 65% alcohol reflux 3 times, merge 3 extracting solution, concentrating under reduced pressure obtains rare extractum, upper polyamide column, 90% ethanol elution is used again after first colourless to effluent with 20% ethanol elution, collect ethanol elution, decompression recycling ethanol, to without alcohol taste, continues to be concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine;
(2) after Rhizoma Gymnadeniae, Radix Rehmanniae Preparata, Rhizoma Cyperi, the Radix Paeoniae Alba, the Radix Astragali, Radix Phyllagathis fordii and Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri second being extracted, filtering residue decocts with water secondary, first time add water into medical material weight portion 4-10 doubly, decoct 1.0-1.5 hour, second time adds water as the 3-8 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05 (60 DEG C record), adding ethanol makes alcohol content reach 55%, leaves standstill 12 hours, filters, filtrate recycling ethanol, be concentrated into extractum, lyophilization, obtain the dry cream of Chinese medicine;
Mix homogeneously after (1) is broken with the Chinese medicine dried cream powder of (2) gained, make tablet according to galenic pharmacy routine techniques.
Embodiment 10
Prescription: Rhizoma Gymnadeniae 20 parts, Radix Rehmanniae Preparata 15 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Cyperi 9 parts, the Radix Paeoniae Alba 8 parts, Herba Lycopi 15 parts, Herba Leonuri 15 parts, Radix Phyllagathis fordii 18 parts.
Preparation method: Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri are pulverized by (1), with 67% alcohol reflux 3 times, merge 3 extracting solution, concentrating under reduced pressure obtains rare extractum, upper polyamide column, 90% ethanol elution is used again after first colourless to effluent with 20% ethanol elution, collect ethanol elution, decompression recycling ethanol, to without alcohol taste, continues to be concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine;
(2) after Rhizoma Gymnadeniae, Radix Rehmanniae Preparata, Rhizoma Cyperi, the Radix Paeoniae Alba, the Radix Astragali, Radix Phyllagathis fordii and Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri second being extracted, filtering residue decocts with water secondary, first time add water into medical material weight portion 4-10 doubly, decoct 1.0-1.5 hour, second time adds water as the 3-8 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.06 (60 DEG C record), adding ethanol makes alcohol content reach 55%, leaves standstill 12 hours, filters, filtrate recycling ethanol, be concentrated into extractum, lyophilization, obtain the dry cream of Chinese medicine;
Mix homogeneously after (1) is broken with the Chinese medicine dried cream powder of (2) gained, make granule according to galenic pharmacy routine techniques.
Claims (8)
1. treat the thin Chinese medicine preparation causing hypomenorrhea of endometrium, it is characterized in that by Rhizoma Gymnadeniae, Radix Et Caulis Acanthopanacis Senticosi, Radix Rehmanniae Preparata, Rhizoma Cyperi, the Radix Paeoniae Alba, the Radix Astragali, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri, Radix Phyllagathis fordii be medicinal raw material elaborate.
2. Chinese medicine preparation as claimed in claim 1, is characterized in that being made up of the raw material of following weight: Rhizoma Gymnadeniae 18-24 part, Radix Rehmanniae Preparata 13-18 part, Radix Et Caulis Acanthopanacis Senticosi 10-15 part, Radix Astragali 13-18 part, Radix Angelicae Sinensis 10-15 part, Rhizoma Cyperi 7-12 part, Radix Paeoniae Alba 6-9 part, Herba Lycopi 11-16 part, Herba Leonuri 14-18 part, Radix Phyllagathis fordii 15-20 part.
3. Chinese medicine preparation as claimed in claim 2, is characterized in that being made up of the raw material of following weight: Rhizoma Gymnadeniae 20 parts, Radix Rehmanniae Preparata 15 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, the Radix Astragali 15 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Cyperi 9 parts, the Radix Paeoniae Alba 8 parts, Herba Lycopi 15 parts, Herba Leonuri 15 parts, Radix Phyllagathis fordii 18 parts.
4. the Chinese medicine preparation as described in claim 1-3, it is characterized in that described Chinese medicine preparation is that Rhizoma Gymnadeniae, Radix Et Caulis Acanthopanacis Senticosi, Radix Rehmanniae Preparata, Rhizoma Cyperi, the Radix Paeoniae Alba, the Radix Astragali, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri, Radix Phyllagathis fordii are extracted effective ingredient as active ingredient using proper method, this composition is independent or mix with medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to galenic pharmacy routine techniques.
5. Chinese medicine preparation as claimed in claim 4, is characterized in that the preparation method of described Chinese medicine preparation comprises the following steps:
(1) Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri are pulverized, with 65-70% alcohol reflux 3 times, merge 3 extracting solution, concentrating under reduced pressure obtains rare extractum, upper polyamide column, 90% ethanol elution is used again after first colourless to effluent with 20% ethanol elution, collect ethanol elution, decompression recycling ethanol, to without alcohol taste, continues to be concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine;
(2) by Rhizoma Gymnadeniae, Radix Rehmanniae Preparata, Rhizoma Cyperi, the Radix Paeoniae Alba, the Radix Astragali, Radix Phyllagathis fordii and Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Herba Lycopi, Herba Leonuri second is extracted rear filtering residue and is decocted with water secondary, first time add water into medical material weight portion 4-10 doubly, decoct 1.0-1.5 hour, second time adds water as the 3-8 of medical material weight portion doubly decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.03-1.08 (60 DEG C record), adding ethanol makes alcohol content reach 55-60% (preferably 55%), leave standstill 12 hours, filter, filtrate recycling ethanol, be concentrated into extractum, lyophilization, obtain the dry cream of Chinese medicine,
Mix homogeneously after (1) is broken with the Chinese medicine dried cream powder of (2) gained, this composition is independent or mix with medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to galenic pharmacy routine techniques.
6. the Chinese medicine preparation as described in claim 1-3, is characterized in that described Chinese medicine preparation is peroral dosage form, as: soft capsule, capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum.
7. Chinese medicine preparation as claimed in claim 6, is characterized in that peroral dosage form is preferably tablet, capsule or granule.
8. Chinese medicine preparation as claimed in claim 7, is characterized in that peroral dosage form is preferably capsule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113018367A (en) * | 2021-03-16 | 2021-06-25 | 南京中医药大学 | Traditional Chinese medicine composition for treating thin endometrial hypomenorrhea and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274373A (en) * | 2011-07-08 | 2011-12-14 | 刘学勤 | Traditional Chinese medicine for treating hypomenorrhea |
| CN104383433A (en) * | 2014-10-30 | 2015-03-04 | 宿州学院 | Traditional Chinese medicine preparation for treating scanty menstruation |
-
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- 2015-12-08 CN CN201510902226.5A patent/CN105311396A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274373A (en) * | 2011-07-08 | 2011-12-14 | 刘学勤 | Traditional Chinese medicine for treating hypomenorrhea |
| CN104383433A (en) * | 2014-10-30 | 2015-03-04 | 宿州学院 | Traditional Chinese medicine preparation for treating scanty menstruation |
Non-Patent Citations (1)
| Title |
|---|
| 黄爱清等: "滋肾活血汤治疗子宫内膜薄致月经过少肾虚血瘀证的疗效观察", 《湖南中医药大学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113018367A (en) * | 2021-03-16 | 2021-06-25 | 南京中医药大学 | Traditional Chinese medicine composition for treating thin endometrial hypomenorrhea and preparation method and application thereof |
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Application publication date: 20160210 |