CN105327067A - Chinese herbal preparation for treating abortion postoperation internal secretion normal type hypomenorrhea - Google Patents
Chinese herbal preparation for treating abortion postoperation internal secretion normal type hypomenorrhea Download PDFInfo
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- CN105327067A CN105327067A CN201510902228.4A CN201510902228A CN105327067A CN 105327067 A CN105327067 A CN 105327067A CN 201510902228 A CN201510902228 A CN 201510902228A CN 105327067 A CN105327067 A CN 105327067A
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Abstract
The invention belongs to the field of traditional Chinese medicine, and relates to a drug for treating irregular menstruation, in particular to a Chinese herbal preparation for treating abortion postoperation internal secretion normal type hypomenorrhea. The Chinese herbal preparation is elaborately prepared from radix rehmanniae praeparata, herba epimedii, angelica sinensis, codonopsis pilosula, rhizoma atractylodis macrocephalae, gorgon euryale seeds, semen cuscutae, rhizoma cyperi, radix cyathulae, stellaria yunnanensis, cyperus michelianus, salvia chinensis, pottsia laxiflora and liquorice. Through combination and interaction of different raw materials, the functions of nourishing yin and reinforcing yang, promoting blood circulation to remove blood stasis, and nourishing blood for regulating menstruation are realized. The blood flow of endometrial spiral arteries can be improved, endometrial blood perfusion can be improved, and then menstruation is improved. Furthermore, the estrogenic and progesterone hormone receptor content of the endometrium can be increased, so that menstruation is improved. Clinical research proves that the Chinese herbal preparation has obvious advantages in treating artificial abortion postoperation internal secretion normal type hypomenorrhea compared with aspirin, the curative effect is better, and adverse reaction is less.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to the medicine for the treatment of menoxenia, particularly relate to a kind of Chinese medicine preparation for the treatment of endocrine normal type hypomenorrhea after abortion.
Background technology
Hypomenorrhea (Hypomenorrhea) refers to that menstrual cycle is normal, and menstrual blood volume obviously reduces, or the deficiency of time 2 days of passing through, even drop and clean person.Hypomenorrhea is the commonly encountered diseases of modern Women of Childbearing Age, it is generally acknowledged hypomenorrhea in 20ml be the diagnosis demarcation line of month hypomenorrhea.This disease betides adolescence and child-bearing period person can develop into amenorrhea, causes sterility and infertility.
Modern Chinese medicine scholar is by summary ancients and in conjunction with tcm clinical practice experience, and the pathogeny proposing hypomenorrhea has void to have reality, thinks that empty person is many because of damage of essence insufficiency of blood, and a sea of blood virtual loss is appointed in punching, the weary source of menses; Reality person is many to stop by blood stasis, or stagnation of phlegm-damp, and punching is appointed and is jammed, hematogenous blockage and hypomenorrhea.Clinical to suffer from a deficiency of the kidney, blood deficiency, blood stasis, phlegm-damp be common.In addition, also think clinically with deficiency syndrome or deficiency complicated with excess person for many, as insufficiency of kidney-YANG, deficiency of kidney-QI all can the hyperamization stasis of blood, i.e. blood stasis due to renal deficiency; Blood deficiency gas is weak, also can cause the stasis of blood; Insufficiency of kidney-YANG, can not warm spleen sun, and dysfunction of the spleen in transportation, Chang Kefa is phlegm-damp of suffering from a deficiency of the kidney.Therefore each pattern of syndrome of hypomenorrhea has Clinical symptoms different separately, for clinical syndrome differentiation provides foundation.
Along with increase pregnant before marrige at present and the rejuvenation at first time at conceived age, cause artificial abortion number of times to increase or forcep curettage, induction of labour increase.Usually see many patient's row artificial abortion clinically and occur hypomenorrhea.Doctor trained in Western medicine gynecological thinks that hypomenorrhea itself is not a kind of disease, but a kind of symptom caused by different reason.After artificial abortion, endometrial impairment causes intrauterine adhesion, Tuberculous pathological changes, the congenital abnormal development in uterus, premature ovarian failure and drug influence etc. all can cause hypomenorrhea.
For the research of the cause of disease of artificial abortion hypomenorrhea, most scholar thinks what the diagnosis with hysteroscope caused due to uteroventral operation caused, and therefore most scholar carrys out with hysteroscopy the hypomenorrhea that diagnosis and treatment artificial abortion causes.But also there is patient's row hysteroscopy of some artificial abortion hypomenorrhea to find to show no obvious abnormalities in uterine cavity; BBT two-phase, gets rid of luteal phase defect; Endocrinological inspection is discovery without exception also.Should how diagnosis and treatment to this kind of patient? at present also not for the medicine of such patient, the traditional Chinese medical science is thought, the amenorrhea system gold sword that artificial abortion causes hindered, belong to eliological factors being neither endogenous nor exogenous category, injury by metallic tools and uterus and vessels of the uterus, make uterus impaired, stagnation of blood stasis therefore occur amenorrhea, thinking that again with the passing of time disease delay causes suffering from a deficiency of the kidney is main and the folder stasis of blood.The traditional Chinese medical science uses the unique theoretical of " preventing exacerbation after being taken ill ", and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, in conjunction with the clinical indices of modern medicine, gives full play to Chinese medicine advantage, compensate for the deficiency of western medicine.
Summary of the invention
Inventor combines theory and the clinical experience of oneself of the sage of the past at all times, for the specificity of artificial abortion endocrine normal type hypomenorrhea patient, by modern physiological pathology and pathogen and pathology of tcm, dialectically to combine with differential diagnosis of diseases, from emphasis and the key of holding disease, provide a kind of Chinese medicine preparation for the treatment of endocrine normal type hypomenorrhea after abortion.
For achieving the above object, the technical solution used in the present invention is:
Treat a Chinese medicine preparation for endocrine normal type hypomenorrhea after abortion, it is medicinal raw material elaborate by Radix Rehmanniae Preparata, Herba Epimedii, Radix Angelicae Sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Euryales, Semen Cuscutae, Rhizoma Cyperi, Radix Cyathulae, Radix Stellariae Yunnanensis, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Herba Salviae Chinensis, Radix Pottsiae Laxiflorae, Radix Glycyrrhizae.
The weight of medicinal raw material of the present invention gropes to sum up to draw through inventor in a large number, and each medicinal raw material all has good curative effect in following weight parts scope: Radix Rehmanniae Preparata 18-24 part, Herba Epimedii 11-15 part, Radix Angelicae Sinensis 8-13 part, Radix Codonopsis 15-20 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Semen Euryales 30-36 part, Semen Cuscutae 10-15 part, Rhizoma Cyperi 8-13 part, Radix Cyathulae 5-8 part, Radix Stellariae Yunnanensis 13-18 part, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 8-13 part, Herba Salviae Chinensis 6-10 part, Radix Pottsiae Laxiflorae 15-20 part, Radix Glycyrrhizae 5-9 part.
Further preferably, treat a Chinese medicine preparation for endocrine normal type hypomenorrhea after abortion, it is characterized in that it is made up of the medicinal raw material of following weight portion: Radix Rehmanniae Preparata 20 parts, Herba Epimedii 12 parts, Radix Angelicae Sinensis 10 parts, Radix Codonopsis 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Semen Euryales 30 parts, Semen Cuscutae 13 parts, Rhizoma Cyperi 9 parts, Radix Cyathulae 7 parts, Radix Stellariae Yunnanensis 15 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 12 parts, Herba Salviae Chinensis 8 parts, Radix Pottsiae Laxiflorae 17 parts, 7 parts, Radix Glycyrrhizae.
Inventor sums up and thinks: artificial abortion damage kidney qi, deficiency of kidney-essence, and no resource of generating and transforming QI and blood, causes vessels of the uterus inanition, and menoxenia due to insufficiency of CHONG meridian is consequently few through row amount; Then gas of suffering from a deficiency of the kidney is weak, and it is slow that gas is weak, insufficiency of blood then circulates, and the stasis of blood is stagnant not smooth, sends out as hypomenorrhea.Fang Zhong, the sweet temperature of Radix Rehmanniae Preparata, nourishing YIN and supplementing blood, beneficial essence fills out marrow, nourishing kidney yin, Herba Epimedii Xin Ganwen, and kind kidney-replenishing, two medicine 5 tonifying kidney-yin invigorating kidney-YANGs, interdependence between yin and yang the kidney invigorating essence is monarch drug.Radix Codonopsis energy spleen reinforcing nourishing the stomach, the lung moistening and production of body fluid promoting, gas in strong fortune, there is the effect of nourishing blood preferably, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, Semen Euryales is sweet puckery flat, spleen reinforcing is reinforced the kidney, help gas arresting seminal emission, three medicines 5 mend the day after tomorrow with spleen reinforcing nourishing the stomach, make QI and blood biochemistry active, nourish blood and do not stay the stasis of blood and add smart principal drug assistance, uncharm and mend true; Radix Angelicae Sinensis specially can be enriched blood, again can promoting the circulation of blood, and invigorating middle warmer has, and have benefit in row, can support nutrition blood, QI invigorating spermatogenesis, with principal drug assistance, is ministerial drug altogether.Semen Cuscutae, the kidney invigorating nourishing the liver, warming the spleen helps stomach; Radix Stellariae Yunnanensis strengthening spleen and nourishing blood, the liver and the kidney tonifying, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) circulation of qi promoting is nourished blood, Rhizoma Cyperi promoting QI circulation for relieving depression, menstruction regulating and pain relieving; Radix Pottsiae Laxiflorae expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, five medicine 5 invigorating QI and bloods, regulating menstruation dredging collateral; Herba Salviae Chinensis is arduous to be slightly cold, blood circulation promoting and blood stasis dispelling, mass dissipating and swelling eliminating; Radix Cyathulae eliminating blood stasis and inducing menstruation, priming is descending, can help Radix Angelicae Sinensis and attack stasis and resolving masses, blood stasis dispelling dysmenorrhea, is adjuvant.Radix Glycyrrhizae invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription, for making medicine.All medicines, combined into it, are mutually use, Yin-nourishing and Yang-supporting, blood circulation promoting and blood stasis dispelling, the merit of nourishing blood for regulating menstruation.
The raw materials used present Research of Chinese medicine preparation of the present invention is as described below:
Radix Rehmanniae Preparata: [nature and flavor] are sweet, tepor.[return through] returns liver, kidney channel.[function cures mainly] nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
Radix Angelicae Sinensis: [nature and flavor] sweet, acrid, warm.[return through] returns liver, the heart, spleen channel.[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Codonopsis: [nature and flavor] are sweet is flat.[return through] returns spleen, lung meridian.[function cures mainly] invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst." book on Chinese herbal medicine justice ": " gas in strong fortune, this is very mutually not far away with Radix Ginseng for Radix Codonopsis power energy spleen reinforcing nourishing the stomach, the lung moistening and production of body fluid promoting.Its outstanding valuable person, then spleen invigorating fortune and not dry, grow stomach-Yin and not wetting, lung moistening and do not violate cold and cool, nourishes blood and partially do not grow greasy, inspiring clear sun, gas in vibration and without just dry fraud.
The Rhizoma Atractylodis Macrocephalae: [nature and flavor] are bitter, sweet, temperature.[return through] returns spleen, stomach warp.[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.Because taste have the blood of the whole body under one's command, and waist umbilicus is its dividing line, and by means of its foster merit just, and blood stasis dare not be delaied.
Semen Cuscutae: [nature and flavor] are sweet, temperature.[return through] returns liver,kidney,spleen warp.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma." book on Chinese herbal medicine converges and says ": " warming the spleen helps the medicine of stomach also for Semen Cuscutae, the kidney invigorating nourishing the liver.But to mend and not high, temperature and not dry, therefore enter kidney channel, void can be mended, in fact can be in order to, cold can temperature, heat can be cool, wet can be dry, dryly can to moisten.
Rhizoma Cyperi: [nature and flavor] pungent, micro-hardship, micro-sweet, flat.[return through] returns liver, spleen, tri-jiao channel.[function cures mainly] promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Radix Cyathulae: [nature and flavor] sweet, micro-hardship, flat.[return through] returns liver, kidney channel.[function cures mainly] eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.For amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.
Herba Epimedii: [nature and flavor] acrid, sweet, warm.[return through] returns liver, kidney channel.[function cures mainly] kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.[usage and dosage] 3 ~ 9g.
Radix Stellariae Yunnanensis: [nature and flavor] are sweet; Property is put down.[return through] liver; Spleen; Kidney channel.[function cures mainly] strengthening spleen and nourishing blood; The liver and the kidney tonifying; Detumescence.Main anemia; Spirit is deficient; Dizzy nervous; Tinnitus dim eyesight; Hectic fever; Seminal emission; Menoxenia; Leukorrhagia; Fracture; Mastitis.[usage and dosage] takes orally: decoct soup, 15-30g; Or fricassee clothes.External: appropriate, fresh goods is smash deposited.
Semen Euryales: [nature and flavor] are sweet; Puckery; Flat.[return through] spleen; Kidney; The heart; Stomach; Liver Channel.[function cures mainly] reinforcing the kindey to control nocturnal emission; Spleen reinforcing stopping leak.Main seminal emission; Nebulousurine; Stranguria with turbid discharge; Leukorrhagia; Incontinence of urine; Loose stool and diarrhea.[usage and dosage] takes orally: decoct soup, 15-30g; Or enter ball, loose, food of also can cooking congee in right amount.
Cyperus michelianus(L.) Link (Herba Cyperi Micheliani): [nature and flavor] acrid in the mouth; Light; Property is put down.[return through] liver; Spleen channel.[function cures mainly] circulation of qi promoting is nourished blood; Regulating menstruation.Main menoxenia; Dysmenorrhea.
Herba Salviae Chinensis: [nature and flavor] acrid in the mouth; Bitter; Cold nature.[return through] returns liver; Spleen channel.[function cures mainly] blood circulation promoting and blood stasis dispelling; Clearing away heat-damp and promoting diuresis; Mass dissipating and swelling eliminating.Main menoxenia; Dysmenorrhea; Amenorrhea; Metrorrhagia, has blood in stool; Jaundice due to damp-heat; Hot toxic-heat and blood stasis; Drench pain; Leukorrhagia; Rheumatic ostalgia; Scrofula; Skin ulcer swells; Acute mastitis; Herpes zoster; Leprosy; Traumatic injury wound is swollen.
Radix Pottsiae Laxiflorae: [nature and flavor] are bitter; Pungent; Slightly warm in nature.[return through] liver; Kidney channel [function cures mainly] expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral.Main air pain of dampness syndrome; Traumatic injury; Women's amenorrhea.
Radix Glycyrrhizae: [nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Chinese medicine preparation of the present invention is active component by Radix Rehmanniae Preparata, Herba Epimedii, Radix Angelicae Sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Euryales, Semen Cuscutae, Rhizoma Cyperi, Radix Cyathulae, Radix Stellariae Yunnanensis, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Herba Salviae Chinensis, Radix Pottsiae Laxiflorae, Radix Glycyrrhizae or its water and/or its extractive with organic solvent or its volatile oil, adds pharmaceutically acceptable adjuvant and be prepared into pharmaceutically conventional peroral dosage form.As: tablet, capsule, granule, syrup, mixture, oral liquid etc.
Preferably, described peroral dosage form is capsule.
Present invention also offers a kind of preparation method for the treatment of the Chinese medicine preparation of endocrine normal type hypomenorrhea after abortion.The present inventor finds under study for action, by optimized fabrication method, can when remaining valid medicine, remove impurity or the part without drug effect, reduce impurity to the interference of therapeutic effect, make this Chinese medicine preparation more effectively, effect is faster, and reduces the consumption of medicine thus, further reduces the misery of patient.Therefore, present invention also offers a kind of method preparing the Chinese medicine composition of above-mentioned treatment decubital ulcer, the method comprises the following steps:
Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Cyathulae, Herba Salviae Chinensis, Radix Pottsiae Laxiflorae are ground into the granule that mean diameter is 40-50 μm, add the alcohol reflux secondary of 75-80%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, be evaporated to dry extract, after lyophilization, be ground into fine powder;
By Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Euryales, Semen Cuscutae, Radix Stellariae Yunnanensis, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), it is that the granule of 40-50 μm is together with Herba Epimedii that Radix Glycyrrhizae powder is broken into mean diameter, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Cyathulae, , Herba Salviae Chinensis, Radix Pottsiae Laxiflorae ethanol extraction filtering residue and Radix Rehmanniae Preparata decoct with water secondary, collecting decoction, adding ethanol makes the volumn concentration of ethanol reach 30% ~ 40%, after stirring, precipitate with ethanol left standstill after 12 hours, get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.20 ~ 1.25 (60 DEG C record), concentrating under reduced pressure is also dry, mix homogeneously with above-mentioned gained fine powder after being ground into fine powder, this composition is independent or mix with medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to galenic pharmacy routine techniques.
Medicine acceptable carrier described above can be selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Preparation of the present invention is in use according to the situation determination usage and dosage of patient.Preparation of the present invention according to the situation determination usage and dosage of patient, can take 1-3 time in use every day, each 1-20 agent, as: 1-20 bag or grain or sheet.
Once there is report to adopt aspirin for treatment endocrine normal and the patient of hypomenorrhea, obtained good effect.Inventor's summing up experience is thought, operator maneuver is improper or dilatation and curettage of uterine number of times too much, may injure endometrium in operation, causes blood vessels of endometrium to damage, hardens, affect endometrial blood perfusion, thus cause hypomenorrhea.Therefore, change the key that endometrial blood perfusion may be this disease for the treatment of, inventor demonstrates the curative effect of Chinese medicine preparation of the present invention further by clinical case, and particulars is as described below:
1 data and method
1.1 physical data: observing goes to a doctor year March in March, 2013 to 2014 is diagnosed as patient 108 example of hypomenorrhea, 18 ~ 37 years old age, married 36 examples in my institute's Out-patient Clinic of Department of Gynecology, unmarried 72 examples, the course of disease is the shortest 5 months, the longest 6 years.Be divided into treatment group 54 example at random, matched group 54 example, two groups of physical data, through statistical procedures difference nonsignificance (P > 0.05), have comparability.
1.2 diagnostic criterias: the diagnostic criteria of the hypomenorrhea of " guideline of clinical investigations of new Chinese medicine treatment menoxenia " promulgated for 2002 according to " Gynecology of Chinese Medicine " and Ministry of Health of the People's Republic of China.
Hypomenorrhea: hypomenorrhea refers to that menstrual cycle is normal, and menstrual blood loss comparatively constant obviously reduces, and even drop is namely clean, or through line time less than 2 days, through the menopathy that amount is also few.
1.3 inclusive criterias: the patient meeting hypomenorrhea diagnostic criteria; Age 20-35 year; There is artificial abortion medical history, hypomenorrhea more than 3 months medical histories; B ultrasonic Monitoring Ovulation day endometrium thickness G reatT.GreaT.GT 8mm; Basal body temperature (BBT) two-phase.
1.4 exclusion standards: age > 35 years old person; There are cryptorrhea, luteal phase defect, uterine cavity organic disease person; There are the Chronic consumptions persons such as hyperthyroidism, tuberculosis, severe anemia; There is oral hormone in 3 months, use contraceptive person; Untoward reaction person is there is in drug administration process; Not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or statistical disposition person.
1.5 Therapeutic Method:
Treatment group: the capsule that menstruation brings into use the embodiment of the present invention 1 to prepare on the 5th day, 2-4 grain, when taking to menstrual onset, subtracted clothes or withdrew, being a course for the treatment of, taking 3 months continuously with 3 months every day.
Matched group: aspirin for treatment, within the 5th day, start oral enteric aspirin from menstruation, every day, 100mg, took to menstrual onset drug withdrawal continuously, is a course for the treatment of, takes 3 months continuously with 3 months, will not other drug treatment during medication.
1.6 treatment fore-and-aft observing indexs:
1.6.1 the change of menstruation--menstrual blood volume color, matter, passes through the time, menstrual cycle.
1.6.2 the endocrine change in side is supervised: when the menstrual cycle 8-10 in the morning of 2-4 days, measure serum FSH, E2 value;
1.6.3 the observation of adverse effect during medication: with or without occurring untoward reaction and record during observing medication, as gastrointestinal upset, anaphylaxis, vaginal bleeding time prolongation etc.As the person that occurs serious adverse reaction, discontinue medication immediately, exit this research.
1.7 statistical methods: adopt SPSS16.0 statistical software to calculate.Each numerical value with
represent, measurement data adopts t inspection, and enumeration data adopts χ
2inspection, with P < 0.05 for difference has statistical significance.
2 results
2.1 criterions of therapeutical effect: start nineteen ninety-five according to State Administration of Traditional Chinese Medicine " People's Republic of China's industry standard--the Chinese medical disease Standardization of diagnosis and curative effect " promulgated, draft following criterion of therapeutical effect: cure: recover normal through amount, maintain more than 3 menstrual cycle; Take a turn for the better: through amount showed increased, or recover menstrual period normal, but more than 3 menstrual cycle can not be maintained; Do not heal: menstrual cycle, unchanged through measuring.
2.2 observation of curative effect
2.2.1 two groups of patient's comparitive study: above-mentioned 108 routine patients include treatment group and matched group in by random principle, often group 54 is routine, and after treatment, treatment group cures 22 examples, and improvement 31 is routine, and do not heal 1 example, total effective rate 98.1%; Matched group cures 10 examples, and take a turn for the better 26 examples, and do not heal 18 examples, and total effective rate 66.6%, treatment group compares with matched group total effective rate notable difference (P < 0.05).In table 1.
Table 1 liang group patient comparitive study (n%, example)
| Group | Number | Cure | Take a turn for the better | Do not heal | Total effective rate % |
| Treatment group | 54 | 22(40.7％) | 31(57.4％) | 1(1.9％) | 98.1％ |
| Matched group | 54 | 10(18.5％) | 26(48.1％) | 18(33.3％) | 66.6％ |
2.2.2 before and after treatment, serum FSH, E2 value compare: the equal no significant difference of FSH, E2 value before treatment group and treatment of control group, represent two groups of case history no significant differences (P > 0.05), FSH, E2 value contrast after treatment, no significant difference (P > 0.05).
The observation of adverse effect during 2.3 medications:
All untoward reaction is there is not during matched group patient medication; 19 routine patients are had to occur slight gastrointestinal reaction during matched group patient medication, as acid regurgitation 6 example, heating installation 5 example, upper abdomen dull pain 4 example, burn feeling 4 example.Treatment group compares with matched group notable difference (P < 0.05).
The control of menstrual blood loss is that the radial and arteria arcuata of basilar artery and the muscle layer of being broken by basal layer shrinks bad control.For endocrine normal type hypomenorrhea patient, we consider that this patient's artificial abortion may not damage basal layer, may be because patient's maneuver is improper or dilatation and curettage of uterine number of times is too much, endometrial blood vessel may be injured in operation, cause endometrial spiral arterial sclerosis, Endometrial blood flow perfusion reduces, thus causes hypomenorrhea.In addition, the improper or dilatation and curettage of uterine number of times of artificial abortion operation maneuver too much also likely damages endometrial Estrogen and progesterone receptors, content receptor is reduced, thus causes hypomenorrhea.
Therefore we infer, Chinese medicine preparation of the present invention may be the blood flow improving endometrial spiral artery, improves endometrial blood perfusion, thus improves menstruation.In addition, also may improve endometrial Estrogen and progesterone receptors content, improve menstruation.Found by research, treatment group treatment artificial abortion endocrine normal type hypomenorrhea comparatively aspirin has significant advantage, and curative effect is better, less adverse effect.
In a word, compared with prior art, the present invention has following beneficial effect:
Selected by invention medicine, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, legislation comprehensively, medication is thoughtful, plays Yin-nourishing and Yang-supporting altogether, blood circulation promoting and blood stasis dispelling, the merit of nourishing blood for regulating menstruation, invigorating middle warmer have rush down, treating YANG within YIN, tonifying both YIN and YANG, incremental, play Chinese medicine preparation Mutiple Targets of the present invention, too many levels, multi-level comprehensive regulation effect, artificial abortion endocrine normal type hypomenorrhea patient can be treated.Chinese medicine preparation clinical efficacy of the present invention is definite, and side effect is less, and patient compliance is better, and taking convenience, can effectively alleviate patient's burden and misery, can reach the object for the treatment of both the principal and secondary aspects of a disease, wide popularization and application on clinic.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Prescription: Radix Rehmanniae Preparata 20 parts, Herba Epimedii 12 parts, Radix Angelicae Sinensis 10 parts, Radix Codonopsis 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Semen Euryales 30 parts, Semen Cuscutae 13 parts, Rhizoma Cyperi 9 parts, Radix Cyathulae 7 parts, Radix Stellariae Yunnanensis 15 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 12 parts, Herba Salviae Chinensis 8 parts, Radix Pottsiae Laxiflorae 17 parts, 7 parts, Radix Glycyrrhizae.
Preparation method:
(1) Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Cyathulae, Herba Salviae Chinensis, Radix Pottsiae Laxiflorae are ground into the granule that mean diameter is 45 μm, add the alcohol reflux secondary of 75%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, be evaporated to dry extract, after lyophilization, be ground into fine powder;
(2) by Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Euryales, Semen Cuscutae, Radix Stellariae Yunnanensis, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), it is that the granule of 45 μm is together with Herba Epimedii that Radix Glycyrrhizae powder is broken into mean diameter, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Cyathulae, Herba Salviae Chinensis, Radix Pottsiae Laxiflorae ethanol extraction filtering residue and Radix Rehmanniae Preparata decoct with water secondary, collecting decoction, adding ethanol makes the volumn concentration of ethanol reach 35%, after stirring, precipitate with ethanol left standstill after 12 hours, get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.23 (60 DEG C record), concentrating under reduced pressure is also dry, mix homogeneously with above-mentioned gained fine powder after being ground into fine powder, make capsule.
Embodiment 2
Prescription: Radix Rehmanniae Preparata 20 parts, Herba Epimedii 12 parts, Radix Angelicae Sinensis 10 parts, Radix Codonopsis 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Semen Euryales 30 parts, Semen Cuscutae 13 parts, Rhizoma Cyperi 9 parts, Radix Cyathulae 7 parts, Radix Stellariae Yunnanensis 15 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 12 parts, Herba Salviae Chinensis 8 parts, Radix Pottsiae Laxiflorae 17 parts, 7 parts, Radix Glycyrrhizae.
Preparation method:
(1) Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Cyathulae, Herba Salviae Chinensis, Radix Pottsiae Laxiflorae are ground into the granule that mean diameter is 40 μm, add the alcohol reflux secondary of 80%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, be evaporated to dry extract, after lyophilization, be ground into fine powder;
(2) by Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Euryales, Semen Cuscutae, Radix Stellariae Yunnanensis, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), it is that the granule of 50 μm is together with Herba Epimedii that Radix Glycyrrhizae powder is broken into mean diameter, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Cyathulae, Herba Salviae Chinensis, Radix Pottsiae Laxiflorae ethanol extraction filtering residue and Radix Rehmanniae Preparata decoct with water secondary, collecting decoction, adding ethanol makes the volumn concentration of ethanol reach 40%, after stirring, precipitate with ethanol left standstill after 12 hours, get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.20 (60 DEG C record), concentrating under reduced pressure is also dry, mix homogeneously with above-mentioned gained fine powder after being ground into fine powder, make capsule.
Embodiment 3
Prescription: Radix Rehmanniae Preparata 20 parts, Herba Epimedii 12 parts, Radix Angelicae Sinensis 10 parts, Radix Codonopsis 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Semen Euryales 30 parts, Semen Cuscutae 13 parts, Rhizoma Cyperi 9 parts, Radix Cyathulae 7 parts, Radix Stellariae Yunnanensis 15 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 12 parts, Herba Salviae Chinensis 8 parts, Radix Pottsiae Laxiflorae 17 parts, 7 parts, Radix Glycyrrhizae.
Preparation method:
(1) Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Cyathulae, Herba Salviae Chinensis, Radix Pottsiae Laxiflorae are ground into the granule that mean diameter is 40 μm, add the alcohol reflux secondary of 77%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, be evaporated to dry extract, after lyophilization, be ground into fine powder;
(2) by Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Euryales, Semen Cuscutae, Radix Stellariae Yunnanensis, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), it is that the granule of 45 μm is together with Herba Epimedii that Radix Glycyrrhizae powder is broken into mean diameter, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Cyathulae, Herba Salviae Chinensis, Radix Pottsiae Laxiflorae ethanol extraction filtering residue and Radix Rehmanniae Preparata decoct with water secondary, collecting decoction, adding ethanol makes the volumn concentration of ethanol reach 37%, after stirring, precipitate with ethanol left standstill after 12 hours, get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.22 (60 DEG C record), concentrating under reduced pressure is also dry, mix homogeneously with above-mentioned gained fine powder after being ground into fine powder, make capsule.
Embodiment 4
Prescription: Radix Rehmanniae Preparata 18 parts, Herba Epimedii 14 parts, Radix Angelicae Sinensis 8 parts, Radix Codonopsis 20 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Semen Euryales 35 parts, Semen Cuscutae 10 parts, Rhizoma Cyperi 10 parts, Radix Cyathulae 5 parts, Radix Stellariae Yunnanensis 18 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 10 parts, Herba Salviae Chinensis 9 parts, Radix Pottsiae Laxiflorae 15 parts, 6 parts, Radix Glycyrrhizae.
Preparation method:
(1) Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Cyathulae, Herba Salviae Chinensis, Radix Pottsiae Laxiflorae are ground into the granule that mean diameter is 47 μm, add the alcohol reflux secondary of 75%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, be evaporated to dry extract, after lyophilization, be ground into fine powder;
(2) by Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Euryales, Semen Cuscutae, Radix Stellariae Yunnanensis, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), it is that the granule of 42 μm is together with Herba Epimedii that Radix Glycyrrhizae powder is broken into mean diameter, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Cyathulae, Herba Salviae Chinensis, Radix Pottsiae Laxiflorae ethanol extraction filtering residue and Radix Rehmanniae Preparata decoct with water secondary, collecting decoction, adding ethanol makes the volumn concentration of ethanol reach 33%, after stirring, precipitate with ethanol left standstill after 12 hours, get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.20 (60 DEG C record), concentrating under reduced pressure is also dry, mix homogeneously with above-mentioned gained fine powder after being ground into fine powder, make capsule.
Embodiment 5
Prescription: Radix Rehmanniae Preparata 22 parts, Herba Epimedii 15 parts, Radix Angelicae Sinensis 12 parts, Radix Codonopsis 18 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Semen Euryales 30 parts, Semen Cuscutae 10 parts, Rhizoma Cyperi 13 parts, Radix Cyathulae 5 parts, Radix Stellariae Yunnanensis 18 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 10 parts, Herba Salviae Chinensis 10 parts, Radix Pottsiae Laxiflorae 20 parts, 7 parts, Radix Glycyrrhizae.
Preparation method: reference example 1-4.
Embodiment 6
Prescription: Radix Rehmanniae Preparata 24 parts, Herba Epimedii 15 parts, Radix Angelicae Sinensis 12 parts, Radix Codonopsis 18 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Semen Euryales 35 parts, Semen Cuscutae 15 parts, Rhizoma Cyperi 12 parts, Radix Cyathulae 8 parts, Radix Stellariae Yunnanensis 13 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 12 parts, Herba Salviae Chinensis 8 parts, Radix Pottsiae Laxiflorae 15 parts, 6 parts, Radix Glycyrrhizae.
Preparation method: reference example 1-4.
Embodiment 7
Prescription: Radix Rehmanniae Preparata 18 parts, Herba Epimedii 14 parts, Radix Angelicae Sinensis 8 parts, Radix Codonopsis 15 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Semen Euryales 35 parts, Semen Cuscutae 10 parts, Rhizoma Cyperi 12 parts, Radix Cyathulae 7 parts, Radix Stellariae Yunnanensis 18 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 12 parts, Herba Salviae Chinensis 10 parts, Radix Pottsiae Laxiflorae 20 parts, 5 parts, Radix Glycyrrhizae.
Preparation method: reference example 1-4.
Embodiment 8
Prescription: Radix Rehmanniae Preparata 20 parts, Herba Epimedii 15 parts, Radix Angelicae Sinensis 8 parts, Radix Codonopsis 18 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Semen Euryales 33 parts, Semen Cuscutae 13 parts, Rhizoma Cyperi 12 parts, Radix Cyathulae 8 parts, Radix Stellariae Yunnanensis 15 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 10 parts, Herba Salviae Chinensis 6 parts, Radix Pottsiae Laxiflorae 20 parts, 7 parts, Radix Glycyrrhizae.
Radix Rehmanniae Preparata 18-24 part, Herba Epimedii 11-15 part, Radix Angelicae Sinensis 8-13 part, Radix Codonopsis 15-20 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Semen Euryales 30-36 part, Semen Cuscutae 10-15 part, Rhizoma Cyperi 8-13 part, Radix Cyathulae 5-8 part, Radix Stellariae Yunnanensis 13-18 part, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 8-13 part, Herba Salviae Chinensis 6-10 part, Radix Pottsiae Laxiflorae 15-20 part, Radix Glycyrrhizae 5-9 part.
Preparation method: reference example 1-4.
Claims (7)
1. treat a Chinese medicine preparation for endocrine normal type hypomenorrhea after abortion, it is characterized in that by Radix Rehmanniae Preparata, Herba Epimedii, Radix Angelicae Sinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Euryales, Semen Cuscutae, Rhizoma Cyperi, Radix Cyathulae, Radix Stellariae Yunnanensis, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Herba Salviae Chinensis, Radix Pottsiae Laxiflorae, Radix Glycyrrhizae be medicinal raw material elaborate.
2. Chinese medicine preparation as claimed in claim 1, is characterized in that being made up of the medicinal raw material of following weight portion: Radix Rehmanniae Preparata 18-24 part, Herba Epimedii 11-15 part, Radix Angelicae Sinensis 8-13 part, Radix Codonopsis 15-20 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Semen Euryales 30-36 part, Semen Cuscutae 10-15 part, Rhizoma Cyperi 8-13 part, Radix Cyathulae 5-8 part, Radix Stellariae Yunnanensis 13-18 part, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 8-13 part, Herba Salviae Chinensis 6-10 part, Radix Pottsiae Laxiflorae 15-20 part, Radix Glycyrrhizae 5-9 part.
3. Chinese medicine preparation as claimed in claim 2, is characterized in that being made up of the medicinal raw material of following weight portion: Radix Rehmanniae Preparata 20 parts, Herba Epimedii 12 parts, Radix Angelicae Sinensis 10 parts, Radix Codonopsis 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Semen Euryales 30 parts, Semen Cuscutae 13 parts, Rhizoma Cyperi 9 parts, Radix Cyathulae 7 parts, Radix Stellariae Yunnanensis 15 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 12 parts, Herba Salviae Chinensis 8 parts, Radix Pottsiae Laxiflorae 17 parts, 7 parts, Radix Glycyrrhizae.
4. the Chinese medicine preparation as described in as arbitrary in claim 1-3, is characterized in that described Chinese medicine preparation is peroral dosage form.
5. Chinese medicine preparation as claimed in claim 4, is characterized in that described peroral dosage form is preferably tablet, capsule, granule, syrup, mixture, oral liquid, etc.
6. Chinese medicine preparation as claimed in claim 5, is characterized in that described peroral dosage form is preferably capsule.
7. the Chinese medicine preparation as described in as arbitrary in claim 1-6, is characterized in that preparation method comprises the following steps:
(1) Herba Epimedii, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Cyathulae, Herba Salviae Chinensis, Radix Pottsiae Laxiflorae are ground into the granule that mean diameter is 40-50 μm, add the alcohol reflux secondary of 75-80%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, be evaporated to dry extract, after lyophilization, be ground into fine powder;
(2) by Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Euryales, Semen Cuscutae, Radix Stellariae Yunnanensis, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), it is that the granule of 40-50 μm is together with Herba Epimedii that Radix Glycyrrhizae powder is broken into mean diameter, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Cyathulae, Herba Salviae Chinensis, Radix Pottsiae Laxiflorae ethanol extraction filtering residue and Radix Rehmanniae Preparata decoct with water secondary, collecting decoction, adding ethanol makes the volumn concentration of ethanol reach 30% ~ 40%, after stirring, precipitate with ethanol left standstill after 12 hours, get supernatant and reclaim ethanol, and to be concentrated into relative density be 1.20 ~ 1.25 (60 DEG C record), concentrating under reduced pressure is also dry, mix homogeneously with above-mentioned gained fine powder after being ground into fine powder, this composition is independent or mix with medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to galenic pharmacy routine techniques.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999155A (en) * | 2016-06-15 | 2016-10-12 | 山东中医药大学附属医院 | Traditional Chinese medicine for treating thin endometrium |
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| KR20150015206A (en) * | 2013-07-31 | 2015-02-10 | 고결 | Method for making products containing korean composition material |
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| CN102579669A (en) * | 2012-03-05 | 2012-07-18 | 宁夏紫荆花制药有限公司 | Chinese medicinal composition for nourishing qi and blood and conditioning menstruation and preparation method thereof |
| KR20150015206A (en) * | 2013-07-31 | 2015-02-10 | 고결 | Method for making products containing korean composition material |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999155A (en) * | 2016-06-15 | 2016-10-12 | 山东中医药大学附属医院 | Traditional Chinese medicine for treating thin endometrium |
| CN105999155B (en) * | 2016-06-15 | 2019-11-15 | 山东中医药大学附属医院 | It is a kind of to treat the thin Chinese medicine of endometrium |
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