CN105395880A - Medicinal preparation for treating secondary amenorrhea caused by intrauterine adhesion - Google Patents

Medicinal preparation for treating secondary amenorrhea caused by intrauterine adhesion Download PDF

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CN105395880A
CN105395880A CN201510999493.9A CN201510999493A CN105395880A CN 105395880 A CN105395880 A CN 105395880A CN 201510999493 A CN201510999493 A CN 201510999493A CN 105395880 A CN105395880 A CN 105395880A
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pharmaceutical preparation
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rhizoma
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刘树芹
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Abstract

The invention belongs to the field of traditional Chinese medicine and discloses a medicinal preparation for treating secondary amenorrhea caused by intrauterine adhesion. The medicinal preparation is prepared from, by weight, 15-25 parts of Chinese dodder seeds, 20-40 parts of Chinese wolfberry fruits, 10-20 parts of prepared rehmannia roots, 20-35 parts of abrus cantoniensis, 10-15 parts of euonymus oxyphyllus, 20-30 parts of conic gymnadenia tuber, 5-15 parts of licorice roots, 8-18 parts of cynanchum wilfordii, 10-20 parts of stellaria yunnanensis, 10-20 parts of Korean raspberry roots, 3-10 parts of bidentate achyranthes roots, 5-15 parts of nutgrass galingale rhizomes and 5-15 parts of fructus liquidambaris. The medicinal preparation has the effects of tonifying the kidney, nourishing the liver, promoting blood circulation to remove blood stasis and regulating thoroughfare and conception vessels, tonification and purgation are conducted in combination, and the curative effect is remarkable.

Description

A kind of pharmaceutical preparation for secondary amenorrhea caused by intrauterine adhesion
Technical field
The invention belongs to the field of Chinese medicines, disclose a kind of pharmaceutical preparation for secondary amenorrhea caused by intrauterine adhesion.
Background technology
All woman have passed through and have interrupted more than 6 months persons, and diagnosable is secondary amenorrhea.Cause the reason of secondary amenorrhea a lot of in clinical, wherein the caused amenorrhea of intrauterine adhesion (IUA) is on the rise.The morbidity about 90% of intrauterine adhesion (IUA) is caused by dilatation and curettage of uterine, and this mainly damages relevant with secondary infection with uteroventral operation, and moderate or severe intrauterine adhesion, more than 75% occurs amenorrhea or hypomenorrhea.Along with the extensive use of Hysteroscopy, for the early diagnosis and therapy of IUA creates condition.
At present, the Adhesionlysis that adopts postoperative with Western medicine artificial cycle therapy for treating more clinically.Existing western medical treatment often toxic and side effects is comparatively large, and easily recurs after drug withdrawal, and therapeutic effect is unsatisfactory, and people usually seek help from Chinese medicine.The traditional Chinese medical science is thought, dilatation and curettage of uterine is hindered by golden sword repeatedly, or more than puerperal, blood is clean, and pathogen is taken advantage of a weak point, and uterus is appointed in the stagnant punching of the stasis of blood, or because of habitual abortion damage kidney qi, asthenia of essence and blood, and a sea of blood virtual loss is appointed in the punching of vessels of the uterus inanition, thus occurs hypomenorrhea, amenorrhea, the disease such as infertile.Chinese medicine has the feature of overall regulation and control, multisystem, too many levels, Mutiple Targets, is controlled, obviously can improve the clinical symptoms of patient, reach the object for the treatment of both the principal and secondary aspects of a disease by integral syndrome differentiation opinion.
Summary of the invention
Inventor combines theory and the clinical experience of oneself of the sage of the past at all times, by modern physiological pathology and pathogen and pathology of tcm, dialectically to combine with differential diagnosis of diseases, provide a kind of pharmaceutical preparation for secondary amenorrhea caused by intrauterine adhesion, it has the kidney invigorating nourishing the liver, blood circulation promoting and blood stasis dispelling, the effect of Chong and Ren Meridians regulating, reinforcement and elimination in combination, evident in efficacy.
The technical solution used in the present invention is as follows:
A kind of pharmaceutical preparation for secondary amenorrhea caused by intrauterine adhesion, it is made up of following medicinal raw material: Semen Cuscutae, Fructus Lycii, Radix Rehmanniae Preparata, Caulis et Folium Desmodii Gangetici, Cortex seu Radix Euonymi oxyphyllae, Rhizoma Gymnadeniae, Radix Glycyrrhizae, Radix cynanchi wilfordii, Radix Stellariae Yunnanensis, Radix rubi coreani, Radix Achyranthis Bidentatae, Rhizoma Cyperi, Fructus Liquidambaris, in side, the weight portion of each medicinal raw material is as follows: Semen Cuscutae 15-25 part, Fructus Lycii 20-40 part, Radix Rehmanniae Preparata 10-20 part, Caulis et Folium Desmodii Gangetici 20-35 part, Cortex seu Radix Euonymi oxyphyllae 10-15 part, Rhizoma Gymnadeniae 20-30 part, Radix Glycyrrhizae 5-15 part, Radix cynanchi wilfordii 8-18 part, Radix Stellariae Yunnanensis 10-20 part, Radix rubi coreani 10-20 part, Radix Achyranthis Bidentatae 3-10 part, Rhizoma Cyperi 5-15 part, Fructus Liquidambaris 5-15 part.
Fang Zhong: the sweet temperature of Semen Cuscutae, nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, kind kidney-replenishing; The sweet tepor of Radix Rehmanniae Preparata, nourishing YIN and supplementing blood, beneficial essence fills out marrow, kind tonifying kidney-yin; Fructus Lycii is sweet flat, flat invigorating the liver and kidney, three medicine 5 tonifying kidney-yins, invigorating kidney-YANG, kidney qi is rushed and is full of, and adjusting punching to appoint, is monarch drug.The regulating menstruation of Caulis et Folium Desmodii Gangetici blood stasis dispelling; Cortex seu Radix Euonymi oxyphyllae expelling wind and removing dampness, promoting blood circulation to restore menstrual flow is ministerial drug.Rhizoma Gymnadeniae Yishen Jianpi, regulates the flow of vital energy and blood; Radix cynanchi wilfordii invigorating the liver and kidney, bone and muscle strengthening, strengthening the spleen and stomach; Radix Stellariae Yunnanensis strengthening spleen and nourishing blood, the liver and the kidney tonifying, three medicine 5 both principal drug assistance invigorating the liver and kidney, strengthening the spleen and stomach again, mending the day after tomorrow to make essence and blood biochemistry active, is adjuvant drug.Radix rubi coreani regulating menstruation and activating blood; Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards, helps ministerial drug promoting blood circulation by removing blood stasis to stimulate the menstrual flow, and is also adjuvant drug.Rhizoma Cyperi is soothing the liver circulation of qi promoting, QI and blood regulating; Fructus Liquidambaris expelling wind and removing dampness, soothing the liver active, diuretic stimulates the menstrual flow, and is adjuvant.Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making medicine.Full side's tonifying both YIN and YANG, Yin grows while yang is generating, finally make negative and positive coordinated balance in kidney, kidney qi fills Sheng, and menstruation continues to rise.
Further preferably, for a pharmaceutical preparation for secondary amenorrhea caused by intrauterine adhesion, it is made up of the medicinal raw material of following weight distribution ratio: Semen Cuscutae 18-23 part, Fructus Lycii 28-34 part, Radix Rehmanniae Preparata 12-16 part, Caulis et Folium Desmodii Gangetici 25-30 part, Cortex seu Radix Euonymi oxyphyllae 10-15 part, Rhizoma Gymnadeniae 20-25 part, Radix Glycyrrhizae 7-12 part, Radix cynanchi wilfordii 11-15 part, Radix Stellariae Yunnanensis 15-20 part, Radix rubi coreani 12-17 part, Radix Achyranthis Bidentatae 5-9 part, Rhizoma Cyperi 10-15 part, Fructus Liquidambaris 7-12 part.
Further preferably, for a pharmaceutical preparation for secondary amenorrhea caused by intrauterine adhesion, it is made up of the medicinal raw material of following weight distribution ratio: Semen Cuscutae 20 parts, Fructus Lycii 30 parts, Radix Rehmanniae Preparata 15 parts, Caulis et Folium Desmodii Gangetici 25 parts, Cortex seu Radix Euonymi oxyphyllae 12 parts, Rhizoma Gymnadeniae 23 parts, 9 parts, Radix Glycyrrhizae, Radix cynanchi wilfordii 12 parts, Radix Stellariae Yunnanensis 18 parts, Radix rubi coreani 13 parts, Radix Achyranthis Bidentatae 7 parts, Rhizoma Cyperi 12 parts, Fructus Liquidambaris 8 parts.
The pharmacology activity research present situation of we's each medical material used is as follows.
Caulis et Folium Desmodii Gangetici: [nature and flavor] Gan Xin; Flat.[return through] Liver Channel.The regulating menstruation of [function cures mainly] blood stasis dispelling, removing toxic substances, pain relieving.Main traumatic injury, uterine prolapse, proctoptosis, amenorrhea, psoriasis, toothache, headache.
Cortex seu Radix Euonymi oxyphyllae: [nature and flavor] are bitter; Pungent; Flat.[return through] heart; Large intestine; Liver Channel.[function cures mainly] expelling wind and removing dampness; Promoting blood circulation to restore menstrual flow; Promoting diuresis to remove toxic substance.Main air pain of dampness syndrome; Dysentery; Have loose bowels; Dysmenorrhea; Amenorrhea; Injury and bone fracture; Foot gas; Edema; Scrotum pruritus due to damp pathogen; Sore swollen toxin.
Rhizoma Gymnadeniae: [nature and flavor] are sweet; Flat.[return through] lung; Spleen; Stomach warp.[function cures mainly] relieving cough and asthma; Yishen Jianpi; Regulate the flow of vital energy and blood; Pain relieving.Main cough and asthma due to lung deficiency; Asthenia is become thin; Neurasthenia; Suffer from a deficiency of the kidney lassitude loin and legs; Sexual impotence; Spermatorrhea; Frequent micturition; Chronic hepatitis; Chronic diarrhea; Lose blood; Leukorrhagia; Breast is few; Traumatic injury.. " Shaanxi Chinese herbal medicine ": strengthening by means of tonics, spleen reinforcing lung moistening, calms the nerves relieving convulsion, QI invigorating pain relieving.Control physical weakness, neurasthenia, impairment caused by overstrain, cough, asthma.
Semen Cuscutae: [nature and flavor] are sweet, temperature.[return through] returns liver,kidney,spleen warp.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Fructus Lycii: [nature and flavor] are sweet is flat.[return through] returns liver, kidney channel.[function cures mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Radix Rehmanniae Preparata: [nature and flavor] are sweet, tepor.[return through] returns liver, kidney channel.[function cures mainly] nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
Radix cynanchi wilfordii: Radix cynanchi wilfordii, heat-insulating mechanism, Radix Cynanchi Auriculati, white Radix Polygoni Multiflori, mountain Fructus Trichosanthis.[nature and flavor] sweet in the mouth; Micro-hardship; Slightly warm in nature; [return through] spleen; Stomach; Kidney channel.[function cures mainly] invigorating the liver and kidney; Bone and muscle strengthening; Strengthening the spleen and stomach; Removing toxic substances.Main Liver and kidney two is empty; Feel dizzy; Insomnia forgetfulness; Early whitening of beard and hair; Sexual impotence; Seminal emission; The acid of waist knee joint is climbed; Spleen insufficiency; Distension and fullness in the abdomen; Ren is for depressed; Have loose bowels; Puerperal, breast was few; Lymphogranuloma inguinale sore.
Radix Stellariae Yunnanensis: be the root of pinkwort Yunnan Herba stellariae mediae.[nature and flavor] are sweet; Property is put down.[return through] liver; Spleen; Kidney channel.[function cures mainly] strengthening spleen and nourishing blood; The liver and the kidney tonifying; Detumescence.Main anemia; Spirit is deficient; Dizzy nervous; Tinnitus dim eyesight; Hectic fever; Seminal emission; Menoxenia; Leukorrhagia; Fracture; Mastitis.
Radix rubi coreani: [nature and flavor] are pained; Flat; Nontoxic.[return through] returns liver, kidney channel.[function cures mainly] promoting blood circulation and hemostasis, expelling wind and removing dampness.Main traumatic injury, fracture, menoxenia, spits blood, epistaxis, rheumatic arthralgia, edema, dysuria, scrofula." Shaanxi Chinese herbal medicine " carries: " regulating menstruation and activating blood, hemostasis and pain-relieving.Control traumatic injury, fracture, infertility, menoxenia, epistaxis." modern medicine study confirmation, Radix rubi coreani has promoting flow of QI and blood, and effect of raw kidney water, controls over-strained hemoptysis, menoxenia, the diseases such as sub-scrofula of itching.
Radix Achyranthis Bidentatae: [nature and flavor] are bitter, sour is flat.[return through] returns liver, kidney channel.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
Rhizoma Cyperi: [nature and flavor] pungent, micro-hardship, micro-sweet, flat.[return through] returns liver, spleen, tri-jiao channel.[function cures mainly] promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Fructus Liquidambaris: [nature and flavor] are bitter; Flat.[return through] 12 warps.[function cures mainly] expelling wind and removing dampness; Soothing the liver active; Diuretic.Main air pain of dampness syndrome; Numb limbs and tense tendons; Contracture of the limbs; Epigastric pain; Amenorrhea; Galactostasis; Edema distension; Eczema.
Radix Glycyrrhizae: [nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
In order to express pharmaceutical preparation of the present invention better, pharmaceutical preparation of the present invention can be active component by Semen Cuscutae, Fructus Lycii, Radix Rehmanniae Preparata, Caulis et Folium Desmodii Gangetici, Cortex seu Radix Euonymi oxyphyllae, Rhizoma Gymnadeniae, Radix Glycyrrhizae, Radix cynanchi wilfordii, Radix Stellariae Yunnanensis, Radix rubi coreani, Radix Achyranthis Bidentatae, Rhizoma Cyperi, Fructus Liquidambaris or its water or its extractive with organic solvent, this composition is independent or mix with medicine acceptable carrier, makes according to galenic pharmacy routine techniques.
Described pharmaceutically acceptable carrier, as mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Pharmaceutical preparation of the present invention is preferably made for peroral dosage form, as: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution or plaster etc.The peroral dosage form of pharmaceutical preparation further preferably of the present invention is tablet, capsule or granule, most preferably is capsule.
Present invention also offers a kind of preparation method of described pharmaceutical preparation, the present inventor finds under study for action, by optimized fabrication method, can when remaining valid medicine, remove impurity or the part without drug effect, reduce impurity to the interference of therapeutic effect, make this pharmaceutical preparation more effective, and reduce the consumption of medicine thus.
The preparation method of a kind of pharmaceutical preparation for hypomenorrhea caused by intrauterine adhesion provided by the invention, mainly comprises the following steps:
(1) Caulis et Folium Desmodii Gangetici, Cortex seu Radix Euonymi oxyphyllae, Rhizoma Cyperi are added the ethanol extraction secondary of 75%-80%, each 1.5-2.0 hour, collect ethanol extract, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction;
(2) Semen Cuscutae, Fructus Lycii, Radix Rehmanniae Preparata, Rhizoma Gymnadeniae, Radix Glycyrrhizae, Radix cynanchi wilfordii, Radix Stellariae Yunnanensis, Radix rubi coreani, Radix Achyranthis Bidentatae, Fructus Liquidambaris are decocted with water secondary, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract;
(3) step (1) gained ethanol extraction and step (2) gained dry extract are mixed, this composition is independent or mix with medicine acceptable carrier, makes pharmaceutical preparation of the present invention according to galenic pharmacy routine techniques.
The present invention be inventor through repeatedly studying, progressively improve, the good pharmaceutical preparation of last successful a kind of curative effect, and demonstrated the curative effect of pharmaceutical preparation of the present invention by clinical case further, particulars is as described below:
1 data and method
1.1 physical data: all uterine cavities through hysteroscopic diagnosis are adhered and cause the routine patient of secondary amenorrhea 96 and be my Out-patient Department patient of in January, 2013 ~ 2014 year May, are divided into Chinese drug-treated group 48 example at random, matched group 48 example by medical order.23 ~ 34 years old Chinese drug-treated group age, average 27.8 ± 3.6 years old; The course of disease 2 months ~ 5 years, average 2.6 ± 1.2 years, wherein slight 8 examples of intrauterine adhesion, moderate 22 example, severe 18 example; 23 ~ 35 years old matched group age, average 27.4 ± 3.5 years old; The course of disease 2 months ~ 5 years, average 2.5 ± 1.1 years; Wherein slight 8 examples of intrauterine adhesion, moderate 23 example, severe 17 example; Chinese drug-treated group has uteroventral operation to comprise artificial abortion, the clearing heat in the pericardium, examine and scrape, get the medical history such as ring, chronic pelvic inflammatory disease 44 example, and matched group has above-mentioned medical history 45 example.Two groups, at clinical data no significant differences (P > 0.05) such as disease kind, classification, age, the course of disease, lesion degrees, have comparability.
1.2 diagnosis marks: have dilatation and curettage of uterine history, gynecilogical operation or gynecological infection history, show as Hypomenorrhea, the visible uterine cavity scar tissue adherent distortion of Medical Imaging inspection, filling defect, conduit inserts at cervical canal place and is obstructed.
Classify according to adhesion degree: severe: involve uterine cavity >3/4, Uterus wall adhesion or adhesive band plumpness, uterine cavity upper end and fallopian tube closure of openings; Moderate: involve uterine cavity 1/4 ~ 3/4, only adhesive band is formed, the adhesion of ametria wall, and uterine cavity upper end and fallopian tube opening portion are closed; Slight: to involve uterine cavity <1/4, adhesive band is poor or very thin, and uterine cavity upper end and the adhesion of fallopian tube opening are very light or visible;
Intrauterine adhesion causes secondary amenorrhea, and the diagnostic criteria with reference to " the Chinese medical disease Standardization of diagnosis and curative effect " of State Administration of Traditional Chinese Medicine's issue is drafted: all woman have passed through and interrupted more than 6 months persons, and diagnosable is secondary amenorrhea.
1.3 get rid of mark: the secondary amenorrhea caused because of Other diseases; The physiologic amenorrheas such as gestation, suckling, menopause; Reproductive system birth defect and deformity; Because of other reasons as ovulation failure, obstruction of fallopian tube etc. cause; Hormone therapy person is used in 3 months.
1.4 Therapeutic Method:
Application hysteroscopy inspection diagnosis, and classify according to intrauterine adhesion degree.Intrauterine adhesion carries out under being separated in direct-view of hysteroscope, for the operation under B ultrasonic monitoring of tough and tensile connective tissue adherence Separation.If postoperative treats 1 course for the treatment of, secondary amenorrhea, without improvement, can carry out rechecking operation, if desired row the 2nd exclusion.
After Chinese drug-treated group microscopy exclusion, capsule prepared by the oral embodiment of the present invention 1,2-4 grain, was a course for the treatment of with 3 months, took 3 months continuously every day; Matched group adopts estrogen and progestogen associating sequential therapy, oral estradiol valerate tablet (1mg/ grain, Bayer HealthCare Co), each 2mg, and every day 2 times, menstruation starts to take on the 5th day; Add dydrogesterone sheet after ovulation, each 10mg, every day 2 times, take 10 days, treat 3 months.
1.5 efficacy assessment standards: the complete separation criterion of hysteroscope: whole cavity of uterus recovers normal size and form, bilateral salpingo opening is shown clear.
Criterion of therapeutical effect: " the Chinese medical disease Standardization of diagnosis and curative effect " issued with reference to State Administration of Traditional Chinese Medicine is formulated, secondary amenorrhea: cure: menstrual onset, continuous more than 3 months menorrhea; Effective: menstruation recovery is risen, but menstrual cycle or abnormal through amount, IUA part is formed again; Do not heal: menstruation is risen not yet, IUA is formed again.
1.6 statistical methods: adopt SPSS16.0 statistical software to calculate.Each numerical value with represent, measurement data adopts t inspection, and enumeration data adopts χ 2inspection, with P < 0.05 for difference has statistical significance.
2 results
2.1 liang of group patient different lesions degree comparitive study: IUA is slight, and Chinese drug-treated group compares with matched group total effective rate, and difference has statistical significance (P < 0.05), shows that Chinese drug-treated group therapeutic effect is better than matched group; IUA moderate, severe Chinese drug-treated group compare with matched group total effective rate, and difference also has statistical significance (P < 0.01), and Chinese drug-treated group therapeutic effect is better than matched group.In table 1.
Table 1 liang group patient different lesions degree comparitive study
Note: compare with matched group, * P < 0.05, * * P < 0.01.
The untoward reaction of 2.2 liang of groups is compared: in therapeutic process, Chinese drug-treated group is without obvious adverse reaction.Nauseating 8 examples of matched group, poor appetite 12 example, uncomfortable 6 examples in gastral cavilty portion, dizziness 2 example.Two groups are compared, and difference has statistical significance, and Chinese drug-treated group less adverse effect, patient compliance is better.
Beneficial effect of the present invention:
Found by treatment, moderate slight for IUA, severe secondary amenorrhea patient, Chinese drug-treated group better effects if.Some patients adopts western medicine to have the reactions such as nauseating, gastral cavilty portion is uncomfortable, therefore the compliance of Chinese medicine is more better.Chinese drug-treated group has good therapeutic effect, in treatment simultaneously, may have adjusted kidney-menses-punching and appoint-uterus axle, improve uterus, ovary tissue blood circulation and supply, promote endometrial growth, improve the factors such as pelvic cavity environment relevant, for Chinese medicine amenorrhea provides new method.
The present invention catches main symptom of suffering from a deficiency of the kidney, and corrects the equilibrium between yin and yang of kidney, logical mend suitable, be association of activity and inertia, should take taste into account, because of The spleen and stomach provide the material basis of the acquired, the source of vital function, plentifully, QI and blood is vigorous, is conducive to endometrial growth and reparation, to recover menorrhea for essence and blood simultaneously.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Prescription: SIZI 20 parts, Fructus Lycii 30 parts, Radix Rehmanniae Preparata 15 parts, Caulis et Folium Desmodii Gangetici 25 parts, Cortex seu Radix Euonymi oxyphyllae 12 parts, Rhizoma Gymnadeniae 23 parts, 9 parts, Radix Glycyrrhizae, Radix cynanchi wilfordii 12 parts, Radix Stellariae Yunnanensis 18 parts, Radix rubi coreani 13 parts, Radix Achyranthis Bidentatae 7 parts, Rhizoma Cyperi 12 parts, Fructus Liquidambaris 8 parts.
Preparation method: Caulis et Folium Desmodii Gangetici, Cortex seu Radix Euonymi oxyphyllae, Rhizoma Cyperi are added the ethanol extraction secondary of 75%-80% by (1), each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction;
(2) Semen Cuscutae, Fructus Lycii, Radix Rehmanniae Preparata, Rhizoma Gymnadeniae, Radix Glycyrrhizae, Radix cynanchi wilfordii, Radix Stellariae Yunnanensis, Radix rubi coreani, Radix Achyranthis Bidentatae, Fructus Liquidambaris are decocted with water secondary, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract;
(3) step (1) gained ethanol extraction and step (2) gained dry extract are mixed, make capsule according to galenic pharmacy routine techniques.
Capsule every prepared by the present embodiment is containing promising 3.0g.
Embodiment 2
Prescription: SIZI 18 parts, Fructus Lycii 33 parts, Radix Rehmanniae Preparata 16 parts, Caulis et Folium Desmodii Gangetici 28 parts, Cortex seu Radix Euonymi oxyphyllae 15 parts, Rhizoma Gymnadeniae 20 parts, 10 parts, Radix Glycyrrhizae, Radix cynanchi wilfordii 15 parts, Radix Stellariae Yunnanensis 15 parts, Radix rubi coreani 15 parts, Radix Achyranthis Bidentatae 5 parts, Rhizoma Cyperi 10 parts, Fructus Liquidambaris 8 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 3
Prescription: SIZI 23 parts, Fructus Lycii 30 parts, Radix Rehmanniae Preparata 16 parts, Caulis et Folium Desmodii Gangetici 30 parts, Cortex seu Radix Euonymi oxyphyllae 15 parts, Rhizoma Gymnadeniae 20 parts, 10 parts, Radix Glycyrrhizae, Radix cynanchi wilfordii 15 parts, Radix Stellariae Yunnanensis 18 parts, Radix rubi coreani 15 parts, Radix Achyranthis Bidentatae 6 parts, Rhizoma Cyperi 15 parts, Fructus Liquidambaris 10 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 4
Prescription: SIZI 15 parts, Fructus Lycii 28 parts, Radix Rehmanniae Preparata 13 parts, Caulis et Folium Desmodii Gangetici 28 parts, Cortex seu Radix Euonymi oxyphyllae 10 parts, Rhizoma Gymnadeniae 20 parts, 5 parts, Radix Glycyrrhizae, Radix cynanchi wilfordii 15 parts, Radix Stellariae Yunnanensis 20 parts, Radix rubi coreani 16 parts, Radix Achyranthis Bidentatae 8 parts, Rhizoma Cyperi 10 parts, Fructus Liquidambaris 12 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 5
Prescription: SIZI 23 parts, Fructus Lycii 30 parts, Radix Rehmanniae Preparata 12 parts, Caulis et Folium Desmodii Gangetici 30 parts, Cortex seu Radix Euonymi oxyphyllae 12 parts, Rhizoma Gymnadeniae 25 parts, 8 parts, Radix Glycyrrhizae, Radix cynanchi wilfordii 15 parts, Radix Stellariae Yunnanensis 15 parts, Radix rubi coreani 20 parts, Radix Achyranthis Bidentatae 3 parts, Rhizoma Cyperi 10 parts, Fructus Liquidambaris 7 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 6
Prescription: SIZI 20 parts, Fructus Lycii 30 parts, Radix Rehmanniae Preparata 12 parts, Caulis et Folium Desmodii Gangetici 27 parts, Cortex seu Radix Euonymi oxyphyllae 15 parts, Rhizoma Gymnadeniae 30 parts, 8 parts, Radix Glycyrrhizae, Radix cynanchi wilfordii 15 parts, Radix Stellariae Yunnanensis 15 parts, Radix rubi coreani 15 parts, Radix Achyranthis Bidentatae 5 parts, Rhizoma Cyperi 9 parts, Fructus Liquidambaris 15 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 7
Prescription: SIZI 22 parts, Fructus Lycii 36 parts, Radix Rehmanniae Preparata 12 parts, Caulis et Folium Desmodii Gangetici 20 parts, Cortex seu Radix Euonymi oxyphyllae 10 parts, Rhizoma Gymnadeniae 23 parts, 9 parts, Radix Glycyrrhizae, Radix cynanchi wilfordii 18 parts, Radix Stellariae Yunnanensis 18 parts, Radix rubi coreani 13 parts, Radix Achyranthis Bidentatae 7 parts, Rhizoma Cyperi 12 parts, Fructus Liquidambaris 10 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 8
Prescription: SIZI 25 parts, Fructus Lycii 40 parts, Radix Rehmanniae Preparata 18 parts, Caulis et Folium Desmodii Gangetici 28 parts, Cortex seu Radix Euonymi oxyphyllae 15 parts, Rhizoma Gymnadeniae 20 parts, 12 parts, Radix Glycyrrhizae, Radix cynanchi wilfordii 16 parts, Radix Stellariae Yunnanensis 15 parts, Radix rubi coreani 10 parts, Radix Achyranthis Bidentatae 7 parts, Rhizoma Cyperi 8 parts, Fructus Liquidambaris 12 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 9
Prescription: SIZI 20 parts, Fructus Lycii 30 parts, Radix Rehmanniae Preparata 15 parts, Caulis et Folium Desmodii Gangetici 25 parts, Cortex seu Radix Euonymi oxyphyllae 12 parts, Rhizoma Gymnadeniae 23 parts, 9 parts, Radix Glycyrrhizae, Radix cynanchi wilfordii 12 parts, Radix Stellariae Yunnanensis 18 parts, Radix rubi coreani 13 parts, Radix Achyranthis Bidentatae 7 parts, Rhizoma Cyperi 12 parts, Fructus Liquidambaris 8 parts.
Preparation method: Caulis et Folium Desmodii Gangetici, Cortex seu Radix Euonymi oxyphyllae, Rhizoma Cyperi are added the ethanol extraction secondary of 75%-80% by (1), each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction;
(2) Semen Cuscutae, Fructus Lycii, Radix Rehmanniae Preparata, Rhizoma Gymnadeniae, Radix Glycyrrhizae, Radix cynanchi wilfordii, Radix Stellariae Yunnanensis, Radix rubi coreani, Radix Achyranthis Bidentatae, Fructus Liquidambaris are decocted with water secondary, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract;
(3) step (1) gained ethanol extraction and step (2) gained dry extract are mixed, make tablet according to galenic pharmacy routine techniques.
Embodiment 10
Prescription: SIZI 20 parts, Fructus Lycii 30 parts, Radix Rehmanniae Preparata 15 parts, Caulis et Folium Desmodii Gangetici 25 parts, Cortex seu Radix Euonymi oxyphyllae 12 parts, Rhizoma Gymnadeniae 23 parts, 9 parts, Radix Glycyrrhizae, Radix cynanchi wilfordii 12 parts, Radix Stellariae Yunnanensis 18 parts, Radix rubi coreani 13 parts, Radix Achyranthis Bidentatae 7 parts, Rhizoma Cyperi 12 parts, Fructus Liquidambaris 8 parts.
Preparation method: Caulis et Folium Desmodii Gangetici, Cortex seu Radix Euonymi oxyphyllae, Rhizoma Cyperi are added the ethanol extraction secondary of 75%-80% by (1), each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction;
(2) Semen Cuscutae, Fructus Lycii, Radix Rehmanniae Preparata, Rhizoma Gymnadeniae, Radix Glycyrrhizae, Radix cynanchi wilfordii, Radix Stellariae Yunnanensis, Radix rubi coreani, Radix Achyranthis Bidentatae, Fructus Liquidambaris are decocted with water secondary, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract;
(3) step (1) gained ethanol extraction and step (2) gained dry extract are mixed, make granule according to galenic pharmacy routine techniques.

Claims (10)

1., for a pharmaceutical preparation for secondary amenorrhea caused by intrauterine adhesion, it is characterized in that being made up of following medicinal raw material: Semen Cuscutae, Fructus Lycii, Radix Rehmanniae Preparata, Caulis et Folium Desmodii Gangetici, Cortex seu Radix Euonymi oxyphyllae, Rhizoma Gymnadeniae, Radix Glycyrrhizae, Radix cynanchi wilfordii, Radix Stellariae Yunnanensis, Radix rubi coreani, Radix Achyranthis Bidentatae, Rhizoma Cyperi, Fructus Liquidambaris.
2. pharmaceutical preparation as claimed in claim 1, is characterized in that being made up of the medicinal raw material of following weight distribution ratio: Semen Cuscutae 15-25 part, Fructus Lycii 20-40 part, Radix Rehmanniae Preparata 10-20 part, Caulis et Folium Desmodii Gangetici 20-35 part, Cortex seu Radix Euonymi oxyphyllae 10-15 part, Rhizoma Gymnadeniae 20-30 part, Radix Glycyrrhizae 5-15 part, Radix cynanchi wilfordii 8-18 part, Radix Stellariae Yunnanensis 10-20 part, Radix rubi coreani 10-20 part, Radix Achyranthis Bidentatae 3-10 part, Rhizoma Cyperi 5-15 part, Fructus Liquidambaris 5-15 part.
3. pharmaceutical preparation as claimed in claim 2, is characterized in that being made up of the medicinal raw material of following weight distribution ratio: Semen Cuscutae 18-23 part, Fructus Lycii 28-34 part, Radix Rehmanniae Preparata 12-16 part, Caulis et Folium Desmodii Gangetici 25-30 part, Cortex seu Radix Euonymi oxyphyllae 10-15 part, Rhizoma Gymnadeniae 20-25 part, Radix Glycyrrhizae 7-12 part, Radix cynanchi wilfordii 11-15 part, Radix Stellariae Yunnanensis 15-20 part, Radix rubi coreani 12-17 part, Radix Achyranthis Bidentatae 5-9 part, Rhizoma Cyperi 10-15 part, Fructus Liquidambaris 7-12 part.
4. pharmaceutical preparation as claimed in claim 3, is characterized in that being made up of the medicinal raw material of following weight distribution ratio: SIZI 20 parts, Fructus Lycii 30 parts, Radix Rehmanniae Preparata 15 parts, Caulis et Folium Desmodii Gangetici 25 parts, Cortex seu Radix Euonymi oxyphyllae 12 parts, Rhizoma Gymnadeniae 23 parts, 9 parts, Radix Glycyrrhizae, Radix cynanchi wilfordii 12 parts, Radix Stellariae Yunnanensis 18 parts, Radix rubi coreani 13 parts, Radix Achyranthis Bidentatae 7 parts, Rhizoma Cyperi 12 parts, Fructus Liquidambaris 8 parts.
5. the pharmaceutical preparation as described in claim 1-4, is characterized in that preparation method mainly comprises the following steps:
(1) Caulis et Folium Desmodii Gangetici, Cortex seu Radix Euonymi oxyphyllae, Rhizoma Cyperi are added the ethanol extraction secondary of 75%-80%, each 1.5-2.0 hour, collect ethanol extract and ethanol extraction filtering residue, concentrating under reduced pressure becomes dry extract, lyophilization, pulverizes to obtain ethanol extraction;
(2) Semen Cuscutae, Fructus Lycii, Radix Rehmanniae Preparata, Rhizoma Gymnadeniae, Radix Glycyrrhizae, Radix cynanchi wilfordii, Radix Stellariae Yunnanensis, Radix rubi coreani, Radix Achyranthis Bidentatae, Fructus Liquidambaris are decocted with water secondary, collecting decoction, filter, filtrate reduced in volume to relative density is 1.05-1.10 (60 DEG C record), adding ethanol makes alcohol content reach 50%, leave standstill 12 hours in 0-10 DEG C, filter, after filtrate recycling ethanol, concentrating under reduced pressure becomes dry extract;
(3) step (1) gained ethanol extraction and step (2) gained dry extract are mixed, this composition is independent or mix with medicine acceptable carrier, makes pharmaceutical preparation of the present invention according to galenic pharmacy routine techniques.
6. the pharmaceutical preparation as described in claim 1-5, is characterized in that described pharmaceutical preparation is peroral dosage form.
7. pharmaceutical preparation as claimed in claim 6, is characterized in that described peroral dosage form is tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, sucks agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution or plaster etc.
8. pharmaceutical preparation as claimed in claim 7, is characterized in that described peroral dosage form is tablet, capsule or granule.
9. pharmaceutical preparation as claimed in claim 8, is characterized in that described peroral dosage form most preferably is capsule.
10. the arbitrary described application of pharmaceutical preparation in the medicine of secondary amenorrhea caused by intrauterine adhesion of claim 1-9.
CN201510999493.9A 2015-12-28 2015-12-28 Medicinal preparation for treating secondary amenorrhea caused by intrauterine adhesion Pending CN105395880A (en)

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CN102908490A (en) * 2012-11-12 2013-02-06 曲庆兰 Traditional Chinese medicine for treating uterine apoxesis amenorrhea diseases
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Application publication date: 20160316