CN105687539A - Pharmaceutical preparation for treating low blocking antibody type recurrent spontaneous abortions - Google Patents
Pharmaceutical preparation for treating low blocking antibody type recurrent spontaneous abortions Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine and relates to a pharmaceutical preparation for treating low blocking antibody type recurrent spontaneous abortions and a preparation method thereof. The pharmaceutical preparation is elaborately prepared from fructus psoraleae, semen cuscutae, textile screw pine seeds, roots of lagerflower triplostegia, roots of gurgeon stopper, rhizoma atractylodis macrocephalae, radix codonopsis, fruits of Chinese magnoliavine, radix angelica sinensis and roots of boerhaavia diffusa according to a certain weight ratio. All the medicinal materials are under compatibility to achieve the effects of tonifying the spleen and kidney, nourishing and activating blood, regulating immunity, promoting increase of blocking antibodies and relieving spleen and kidney depletion, blood stasis and other symptoms, and therefore the treatment effect is achieved.
Description
Technical field
The invention belongs to technical field of Chinese medicine, relate to a kind of pharmaceutical preparation treating the low mo(u)ld bottom half recurrent abortion of blocking antibody and preparation method thereof。
Background technology
Recurrent abortion (recurrentspontaneousabortion, RSA) refers to continuous spontaneous abortion 2 times and more than 2 times persons, its cause of disease is complicated, and except the factors such as heredity, dissection, infection, endocrine, about 40%～65% is relevant with immune factor。The recurrent spontaneous abortion that immune factor causes there are about 2/3 and shows as blocking antibody (blockingantibody, BA) shortage。BA is a kind of antibody with protective effect that the made fetus produced by parent after pregnancy is protected from that mother's immune system is attacked。
RSA many employings spouse's lymphocytes in vitro that BA shortage is caused by modern medicine induces immunotherapy and carries out active immunity treatment, but it has Hematogenous infection, transfusion reaction, graft versus host disease, excites or increase the weight of the Potential danger factors such as autoimmune disease, and passive immunotherapy is blood products and expensive due to medicine, patient is not easily accepted by。
RSA belongs to the traditional Chinese medical science " habitual abortion " category。The traditional Chinese medical science is thought, the kidney being the origin of congenital constitution, reproduction basic, and it is equivalent to " HPA-system " in modern medicine, and immunologic function plays stable regulation effect。The spleen being the foundation of acquired constitution, source of generating QI and blood, the essence of water and grain of its transporting is the material base of immunologic function。If suffering from a deficiency of the kidney or spleen kidney deficiency, deficient qi and blood or host the disease of abdominal mass, injure punching and appoint and all may result in liability to abortion and cause habitual abortion。
The history that Chinese medicine is prevented miscarriage existing several thousand, its curative effect is affirmative。Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is the core of the traditional Chinese medical science, and the traditional Chinese medical science is controlled by integral syndrome differentiation opinion and started with, and treatment primary disease demonstrates obvious advantage, has broad prospects。Most doctors think that the prevention of recurrent abortion overweights treatment, and establish with the theoretical system of prevention of diseae, its damage legislation treatment recurrent abortion of pre-training。It is, therefore, desirable to provide the Chinese medicine composition of a kind of preventing and treating recurrent abortion with better curative effect。
Summary of the invention
Inventor is good at combining modern medical theory with traditional medical theory, dialectical combine with differential diagnosis of diseases, for the etiology and pathogenesis that recurrent abortion blocking antibody is low, based on clinical treatment experience for many years, learn wildly from other's strong points, hammer away, in order to overcome the deficiencies in the prior art, it is provided that a kind of pharmaceutical preparation treating the low mo(u)ld bottom half recurrent abortion of blocking antibody。
For achieving the above object, the present invention adopts the following technical scheme that
A kind of pharmaceutical preparation treating the low mo(u)ld bottom half recurrent abortion of blocking antibody, it is characterised in that by Fructus Psoraleae, Semen Cuscutae, Fructus Pandani tectorii, Radix Triplostegiae Grandiflorae, Radix Syzygii Buxifolii root, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, old come blue or green be that medicinal raw material is made。
In order to increase the synergism of effective active composition in medicine, make all medicines with the use of to reach the one-plus-one technique effect more than two, inventor is through long-term, substantial amounts of screening prescription is tested, it is preferred that following technical scheme: a kind of pharmaceutical preparation treating the low mo(u)ld bottom half recurrent abortion of blocking antibody, it is characterized in that being made up of the medicinal raw material of following weight: Fructus Psoraleae 8-13 part, Semen Cuscutae 15-20 part, Fructus Pandani tectorii 10-15 part, Radix Triplostegiae Grandiflorae 25-30 part, Radix Syzygii Buxifolii root 8-13 part, Rhizoma Atractylodis Macrocephalae 7-12 part, Radix Codonopsis 10-15 part, Fructus Schisandrae Chinensis 1.5-5 part, Radix Angelicae Sinensis 7-12 part, old next blue or green 10-15 part。
Further preferably, a kind of pharmaceutical preparation treating the low mo(u)ld bottom half recurrent abortion of blocking antibody, it is characterised in that be made up of the medicinal raw material of following weight: Fructus Psoraleae 12 parts, Semen Cuscutae 18 parts, Fructus Pandani tectorii 10 parts, Radix Triplostegiae Grandiflorae 25 parts, Radix Syzygii Buxifolii root 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Codonopsis 15 parts, Fructus Schisandrae Chinensis 3 parts, Radix Angelicae Sinensis 10 parts, always next blue or green 12 parts。
Fang Zhong: the arduous temperature of Fructus Psoraleae, warming the kidney to activate YANG is with sun raw in the moon, and warming the spleen helps fortune；The sweet temperature of Semen Cuscutae, tonifying kidney and nourishing liver, temperature reason taste, two medicines are all the key medicine of warming and recuperating the spleen and kidney, combined into benefits and not high, warm and not dry, warming the kidney to activate YANG effect is significantly monarch drug。Radix Angelicae Sinensis sweet in the mouth is pungent, temperature, can rise and can drop, the YIN aspect of YANG, replenishing and activating blood；The sweet micro-hardship of Radix Triplostegiae Grandiflorae is put down, tonifying speen and tonifying kidney, rich in nutrition, promoting blood flow to regulate menstruation；Fructus Pandani tectorii is pungent light cool, can tonifying the spleen and stomach, reinforcing premodial qi, can the pungent using warming therapy medicine of containing, make the property of medicine more gentle, three medicine 5 use, blood yiqi, promoting flow of QI and blood, strengthening spleen, tonifying kidney, for ministerial drug。Radix Syzygii Buxifolii root, kidney tonifying Dingchuan；Invigorating spleen to remove dampness, expelling wind and activating blood circulation, removing toxic substances and promoting subsidence of swelling；Old next blue or green promoting blood circulation to remove blood stasis, bone and muscle strengthening strengthening the spleen kidney；Rhizoma Atractylodis Macrocephalae dehumidifying benefit is dry, and middle QI invigorating, warming middle-JIAO damp eliminating；Radix Codonopsis invigorating the spleen and replenishing QI, lung inspires clear sun,；Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, and supplementing QI for promoting the production of body fluid, kidney calming, for adjuvant drug。All medicines share invigorating spleen and kidney, nourshing blood and promoting blood circulation, regulate immunity, promoting that blocking antibody improves, improving all diseases of deficiency of spleen and stomach blood stasis, thus reaching therapeutic effect。
The pharmaceutical research present situation of each medical material used by the present invention is as described below。
Fructus Psoraleae: [nature and flavor] are pungent, bitter, temperature。[return through] returns kidney, spleen channel。[function cures mainly] warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal。For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, Diarrhoea；External curing vitiligo, alopecia areata。
Semen Cuscutae: [nature and flavor] are sweet, temperature。[return through] returns liver,kidney,spleen warp。[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal。For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down；Externally treating leucoderma。[usage and dosage] 6～12g；Suitable amount used externally。
Fructus Pandani tectorii: [nature and flavor] acrid in the mouth；Light；Cool in nature。[return through] kidney；Spleen；Liver；Stomach warp。[function cures mainly] spleen reinforcing benefit blood；Promoting the circulation of QI to relieve pain；Reduce phlegm dampness removing；Improving eyesight。Main dysentery；Stomachache；Cough；Hernia；Orchitis；Hemorrhoid dysuria；The raw cataracta of order。[usage and dosage] takes orally: decoct soup, 10-30g；Infusing drugs in wine or leaching honey。External: appropriate: decoct washing。
Radix Triplostegiae Grandiflorae: [nature and flavor] hardship sweet, micro-is flat。[function cures mainly] tonifying speen and tonifying kidney, promoting blood flow to regulate menstruation, only metrorrhagia, removing toxic substances。For lumbago due to renal deficiency, anemia, cough, seminal emission, sexual impotence, rheumatic arthritis, menoxenia, vicarious menstruation, metrorrhagia, leukorrhagia, infertility。External is stopped blooding。[usage and dosage] 0.5～1 liang。
Radix Angelicae Sinensis: [nature and flavor] sweet in the mouth, pungent, bitter, warm in nature, [return through] enters liver, the heart, spleen channel, [function cures mainly] replenishing and activating blood, menstruction regulating and pain relieving, profit soup relieving constipation effect, demonstrate,prove for blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores etc.。Modern study shows, Radix Angelicae Sinensis has adjustment body's immunity, replenishing and activating blood, and antibacterial grade acts on。
Radix Syzygii Buxifolii root: [nature and flavor] sweet in the mouth；Micro-hardship；Pungent；Property is put down。[return through] returns kidney；Spleen；Liver Channel。[function cures mainly] kidney tonifying Dingchuan；Invigorating spleen to remove dampness；Expelling wind and activating blood circulation；Removing toxic substances and promoting subsidence of swelling。Master breathes with cough；Edema；Stranguria with turbid discharge；Lithangiuria；Dysentery；Hepatitis；Uterine prolapse；Rheumatalgia；Hernia；Orchitis；Hemorrhoid；Carbuncle；Burn due to hot liquid or fire；Treating swelling and pain by traumatic injury。[usage and dosage] takes orally: decoct soup, 15-30g。External: appropriate, smashes to apply or grind into powder and spreads。
The Rhizoma Atractylodis Macrocephalae: [nature and flavor] are bitter, sweet, temperature。[return through] returns spleen, stomach warp。[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive。For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement。Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive。For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement。
Radix Codonopsis: [nature and flavor] are sweet is flat。[return through] returns spleen, lung meridian。[function cures mainly] invigorating the spleen and replenishing QI, spleen invigorating lung benefiting。For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst。
Fructus Schisandrae Chinensis: [nature and flavor] are sour, sweet, temperature。[return through] returns lung, the heart, kidney channel。[function cures mainly] restrains astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming。For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia。[usage and dosage] 1.5～6g。
Old next blue or green: [nature and flavor] are bitter, pungent, temperature。[function cures mainly] promoting blood circulation to remove blood stasis, bone and muscle strengthening, regulating menstruation, disappear infantile malnutrition；For bones and muscles pain, lumbago and skelalgia, menoxenia, leucorrhea, anorexia, spleen is suffered from a deficiency of the kidney edema, and void is coughed, infantile malnutrition。
In order to express the pharmaceutical preparation of the present invention better, pharmaceutical preparation of the present invention can be active component by Fructus Psoraleae, Semen Cuscutae, Fructus Pandani tectorii, Radix Triplostegiae Grandiflorae, Radix Syzygii Buxifolii root, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, old next blue or green or its water and/or its extractive with organic solvent, adds pharmaceutically acceptable carrier and is prepared from。
The pharmaceutical preparation of the present invention can make any pharmaceutically useful dosage form, and these dosage forms include: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, sucks agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch。
Preferably, pharmaceutical preparation described above is peroral dosage form, as: soft capsule, capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum；It is further preferred that the peroral dosage form of pharmaceutical preparation of the present invention is tablet, capsule or granule, it is most preferred that capsule。
The pharmaceutical preparation of the present invention, applicable pharmaceutically acceptable carrier is optionally added when preparing into medicament, described pharmaceutically acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.。
The preparation method that present invention also offers this pharmaceutical preparation, it comprises the steps:
(1) by prescription take Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old come blue or green addition 3～8 times amount 65% ethanol, reflux, extract, twice, each 1～3 hour, filtering, merge twice filtrate, decompression recycling ethanol is to without alcohol taste, continue concentrating under reduced pressure and become dry extract, lyophilization, pulverize to obtain ethanol extraction；
(2) filtering residue after Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old next blue or green ethanol extraction is merged with Fructus Psoraleae, Semen Cuscutae, Fructus Pandani tectorii, Radix Triplostegiae Grandiflorae, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Fructus Schisandrae Chinensis, add 5～10 times amount water, decoct and extract 1-3 time, each 1～3 hour, merging filtrate, filter, it is concentrated into relative density 1.05-1.10 (60 DEG C of surveys), places to room temperature, add ethanol and make alcohol content reach 30%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filters, and decompression filtrate recycling ethanol is to without alcohol taste, lyophilization, pulverizes to obtain water extract；
(3) by the extract mix homogeneously of step (1)-(2), active constituents of medicine of the present invention is obtained；This composition individually or mixes with pharmaceutically acceptable carrier, makes according to galenic pharmacy routine techniques。
The preparation of present invention situation according to patient in use determines usage and dosage, can take 1-3 time every day, each 1-20 agent, such as: 1-20 bag or grain or sheet。
The present invention is also claimed said medicine preparation purposes in the medicine of the preparation treatment low mo(u)ld bottom half recurrent abortion of blocking antibody。By the embodiment of the present invention 9: in lab index: after treatment, two groups are all significantly improved (P < 0.01) containing AntiCD3 McAb-BE, anti-CD4-BE, anti-CD8-BE total positives number。Treatment group containing AntiCD3 McAb-BE, anti-CD4-BE, anti-CD8-BE total positives number be better than matched group ((P < 0.05)；In symptom integral: after treatment, TCM symptom score is all substantially more less than before treatment, with comparing difference statistically significant (P < 0.01) before treatment, matched group compares with before treatment, no significant difference (P > 0.05)；Compare between two groups after treatment, treatment group is improving soreness of the waist and knees, the aspects such as lazy speech of breathing hard are better than matched group, the minimizing for the treatment of group symptom integral becomes apparent from, difference statistically significant (P < 0.01), illustrate that medicine of the present invention is to improve deficiency of spleen and stomach blood stasis symptom relatively matched group of holding concurrently obvious, more can improve the tcm symptom of RSA patient；In comprehensive therapeutic effect: treatment group and matched group total effective rate respectively 91.7% and 75.0%, two groups of total effective rate comparing differences statistically significant (P < 0.05), the curative effect for the treatment of group is substantially better than matched group。
In a word: compared with prior art, the present invention both have followed Chinese medical discrimination medicine law, having incorporated again modern pharmacology, comprehensively, prescription is rigorous rationally in legislation, full side closes 5 invigorating spleen and kidney, nourshing blood and promoting blood circulation, has Mutiple Targets, too many levels, multi-level comprehensive regulation effect, regulates immunity, promote that blocking antibody improves, improve the effect of all diseases of deficiency of spleen and stomach blood stasis。
The component of the present composition all adopts natural raw material of Chinese medicine, and preparation is easy, medicine source is wide, cost is low for it。It follows the prescriptions principle of the traditional Chinese medical science, reliable effect, mild in medicine property and, toxic and side effects does not occur,
The present invention can not only change the symptom of habitual abortion patient, and can improve the blocking antibody level of habitual abortion patient, promotes that blocking antibody turns sun；On the other hand, treatment by Chinese herbs habitual abortion, the potential risks such as the transfer overcome the propagation passing the infectious disease that active immunity treatment primary disease exists, promoting tumor and anti-graft disease, part infectious disease is carried patient and can also implement treatment, eliminate the fear that Hematogenic infectious disease is propagated by patient。
Detailed description of the invention
Further describing the present invention below by way of specific embodiment, the present invention is not limited only to following example。Within the scope of the invention or without departing from present disclosure, spirit and scope, change, combination or the replacement that the present invention is carried out, will be apparent to the person skilled in the art, and be included within the scope of the present invention。
Embodiment 1 capsule
Prescription: Fructus Psoraleae 12 parts, Semen Cuscutae 18 parts, Fructus Pandani tectorii 10 parts, Radix Triplostegiae Grandiflorae 25 parts, Radix Syzygii Buxifolii root 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Codonopsis 15 parts, Fructus Schisandrae Chinensis 3 parts, Radix Angelicae Sinensis 10 parts, always next blue or green 12 parts。
Preparation method: (1) by prescription take Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old come blue or green addition 6 times amount 65% ethanol, reflux, extract, twice, each 2 hours, filtering, merge twice filtrate, decompression recycling ethanol is to without alcohol taste, continue concentrating under reduced pressure and become dry extract, lyophilization, pulverize to obtain ethanol extraction；
(2) filtering residue after Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old next blue or green ethanol extraction is merged with Fructus Psoraleae, Semen Cuscutae, Fructus Pandani tectorii, Radix Triplostegiae Grandiflorae, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Fructus Schisandrae Chinensis, add 8 times amount water, decoct and extract 2 times, each 1～3 hour, merging filtrate, filter, it is concentrated into relative density 1.07 (60 DEG C of surveys), places to room temperature, add ethanol and make alcohol content reach 30%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filters, and decompression filtrate recycling ethanol is to without alcohol taste, lyophilization, pulverizes to obtain water extract；
(3) by the extract mix homogeneously of step (1)-(2), obtain active constituents of medicine of the present invention, make according to galenic pharmacy routine techniques。The present embodiment capsule every contains crude drug 0.6g。
Embodiment 2 capsule
Prescription: Fructus Psoraleae 10 parts, Semen Cuscutae 15 parts, Fructus Pandani tectorii 12 parts, Radix Triplostegiae Grandiflorae 28 parts, Radix Syzygii Buxifolii root 8 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Codonopsis 10 parts, Fructus Schisandrae Chinensis 2 parts, Radix Angelicae Sinensis 12 parts, always next blue or green 10 parts。
Preparation method: (1) by prescription take Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old come blue or green addition 5 times amount 65% ethanol, reflux, extract, twice, each 1～3 hour, filtering, merge twice filtrate, decompression recycling ethanol is to without alcohol taste, continue concentrating under reduced pressure and become dry extract, lyophilization, pulverize to obtain ethanol extraction；
(2) filtering residue after Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old next blue or green ethanol extraction is merged with Fructus Psoraleae, Semen Cuscutae, Fructus Pandani tectorii, Radix Triplostegiae Grandiflorae, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Fructus Schisandrae Chinensis, add 6 times amount water, decoct and extract 3 times, each 1～3 hour, merging filtrate, filter, it is concentrated into relative density 1.05 (60 DEG C of surveys), places to room temperature, add ethanol and make alcohol content reach 30%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filters, and decompression filtrate recycling ethanol is to without alcohol taste, lyophilization, pulverizes to obtain water extract；
(3) by the extract mix homogeneously of step (1)-(2), obtain active constituents of medicine of the present invention, make according to galenic pharmacy routine techniques。
Embodiment 3 capsule
Prescription: Fructus Psoraleae 10 parts, Semen Cuscutae 15 parts, Fructus Pandani tectorii 15 parts, Radix Triplostegiae Grandiflorae 30 parts, Radix Syzygii Buxifolii root 12 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Radix Codonopsis 12 parts, Fructus Schisandrae Chinensis 1.5 parts, Radix Angelicae Sinensis 8 parts, always next blue or green 15 parts。
Preparation method: (1) by prescription take Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old come blue or green addition 8 times amount 65% ethanol, reflux, extract, twice, each 1～3 hour, filtering, merge twice filtrate, decompression recycling ethanol is to without alcohol taste, continue concentrating under reduced pressure and become dry extract, lyophilization, pulverize to obtain ethanol extraction；
(2) filtering residue after Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old next blue or green ethanol extraction is merged with Fructus Psoraleae, Semen Cuscutae, Fructus Pandani tectorii, Radix Triplostegiae Grandiflorae, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Fructus Schisandrae Chinensis, add 8 times amount water, decoct and extract 2 times, each 1～3 hour, merging filtrate, filter, it is concentrated into relative density 1.09 (60 DEG C of surveys), places to room temperature, add ethanol and make alcohol content reach 30%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filters, and decompression filtrate recycling ethanol is to without alcohol taste, lyophilization, pulverizes to obtain water extract；
(3) by the extract mix homogeneously of step (1)-(2), obtain active constituents of medicine of the present invention, make according to galenic pharmacy routine techniques。
Embodiment 4 capsule
Prescription: Fructus Psoraleae 12 parts, Semen Cuscutae 20 parts, Fructus Pandani tectorii 15 parts, Radix Triplostegiae Grandiflorae 25 parts, Radix Syzygii Buxifolii root 8 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Codonopsis 10 parts, Fructus Schisandrae Chinensis 5 parts, Radix Angelicae Sinensis 8 parts, always next blue or green 10 parts。
Preparation method: the operation with reference to embodiment 1-3 carries out。
Embodiment 5 capsule
Prescription: Fructus Psoraleae 10 parts, Semen Cuscutae 20 parts, Fructus Pandani tectorii 15 parts, Radix Triplostegiae Grandiflorae 28 parts, Radix Syzygii Buxifolii root 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Codonopsis 10 parts, Fructus Schisandrae Chinensis 3 parts, Radix Angelicae Sinensis 10 parts, always next blue or green 15 parts。
Preparation method: the operation with reference to embodiment 1-3 carries out。
Embodiment 6 capsule
Prescription: Fructus Psoraleae 12 parts, Semen Cuscutae 18 parts, Fructus Pandani tectorii 10 parts, Radix Triplostegiae Grandiflorae 30 parts, Radix Syzygii Buxifolii root 12 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Radix Codonopsis 15 parts, Fructus Schisandrae Chinensis 2.5 parts, Radix Angelicae Sinensis 8 parts, always next blue or green 12 parts。
Preparation method: the operation with reference to embodiment 1-3 carries out。
Embodiment 7 tablet
Prescription: Fructus Psoraleae 12 parts, Semen Cuscutae 18 parts, Fructus Pandani tectorii 10 parts, Radix Triplostegiae Grandiflorae 25 parts, Radix Syzygii Buxifolii root 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Codonopsis 15 parts, Fructus Schisandrae Chinensis 3 parts, Radix Angelicae Sinensis 10 parts, always next blue or green 12 parts。
Preparation method: (1) by prescription take Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old come blue or green addition 6 times amount 65% ethanol, reflux, extract, twice, each 1～3 hour, filtering, merge twice filtrate, decompression recycling ethanol is to without alcohol taste, continue concentrating under reduced pressure and become dry extract, lyophilization, pulverize to obtain ethanol extraction；
(2) filtering residue after Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old next blue or green ethanol extraction is merged with Fructus Psoraleae, Semen Cuscutae, Fructus Pandani tectorii, Radix Triplostegiae Grandiflorae, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Fructus Schisandrae Chinensis, add 5 times amount water, decoct and extract 3 times, each 1～3 hour, merging filtrate, filter, it is concentrated into relative density 1.07 (60 DEG C of surveys), places to room temperature, add ethanol and make alcohol content reach 30%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filters, and decompression filtrate recycling ethanol is to without alcohol taste, lyophilization, pulverizes to obtain water extract；
(3) by the extract mix homogeneously of step (1)-(2), obtain active constituents of medicine of the present invention, make according to galenic pharmacy routine techniques。Every, the present embodiment tablet contains crude drug 0.6g。
Embodiment 8 granule
Prescription: Fructus Psoraleae 12 parts, Semen Cuscutae 18 parts, Fructus Pandani tectorii 15 parts, Radix Triplostegiae Grandiflorae 25 parts, Radix Syzygii Buxifolii root 12 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Codonopsis 12 parts, Fructus Schisandrae Chinensis 5 parts, Radix Angelicae Sinensis 12 parts, always next blue or green 12 parts。
Preparation method: (1) by prescription take Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old come blue or green addition 6 times amount 65% ethanol, reflux, extract, twice, each 1～3 hour, filtering, merge twice filtrate, decompression recycling ethanol is to without alcohol taste, continue concentrating under reduced pressure and become dry extract, lyophilization, pulverize to obtain ethanol extraction；
(2) filtering residue after Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old next blue or green ethanol extraction is merged with Fructus Psoraleae, Semen Cuscutae, Fructus Pandani tectorii, Radix Triplostegiae Grandiflorae, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Fructus Schisandrae Chinensis, add 8 times amount water, decoct and extract 2 times, each 1～3 hour, merging filtrate, filter, it is concentrated into relative density 1.05-1.10 (60 DEG C of surveys), places to room temperature, add ethanol and make alcohol content reach 30%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filters, and decompression filtrate recycling ethanol is to without alcohol taste, lyophilization, pulverizes to obtain water extract；
(3) by the extract mix homogeneously of step (1)-(2), obtain active constituents of medicine of the present invention, make according to galenic pharmacy routine techniques。The present embodiment granule every bag contains crude drug 2.0g。
The observation of curative effect of the low mo(u)ld bottom half recurrent abortion of blocking antibody is tested by embodiment 9 pharmaceutical preparation of the present invention
1 data and method
1.1 physical data: in April ,-2014 in April, 2013, RSA patient 96 example that the blocking antibody of my institute's Out-patient Clinic of Department of Gynecology diagnosis and treatment is negative, is randomly divided into treatment group and matched group, wherein treatment group 48 example, 24～35 years old age, year mean age (28.87 ± 3.72)；Abortion times 3～7 times, average (3.14 ± 1.03) are secondary；Matched group 48 example, 23～35 years old age, year mean age (29.20 ± 3.90)；Abortion times 3～6 times, average (3.49 ± 1.22) are secondary, and two groups of patient ages, abortion times compare, no significant difference (P > 0.05), have comparability。
1.2 diagnostic criterias: with reference to Cao Zeyi " China obstetrics and gynecology " relevant criterion: suffer fetal loss person before the gestation 28 weeks of 2 times or more than 2 times with homogeneity companion continuously；At least 1 low person of flow cytomery blocking antibody level (AntiCD3 McAb-BE, anti-CD4-BE, anti-CD8-BE)；
TCM Syndrome Type standard: draft " deficiency of spleen and stomach hold concurrently blood stasis " pattern of syndrome standard with reference to " new Chinese medicine guideline of clinical investigations ", " Gynecology of Chinese Medicine " (Zhang Yuzhen) and " disease of tcm Standardization of diagnosis and curative effect "。Main syndromes: dizziness and tinnitus, soreness of waist and knee, lazy speech of breathing hard, anorexia loose stool, nocturia, there are skin dark stain, twinge, localized pain, tenderness in eye socket darkness or face, venation blood stasis (such as lip, gums, onyx purple are secretly), ecchymosis, long-pending, blood circulating out of vessels, purplish tongue or have ecchymosis petechia, deep-thready pulse or puckery。In above syndrome, " soreness of waist and knee, breathe hard lazy speech, purplish tongue " is indispensable, has 2 in all the other syndromes concurrently, namely diagnosable。
1.3 include in, exclusion standard:
1.3.1 inclusive criteria: meeting above-mentioned diagnostic criteria, the women of child-bearing age at 25～35 years old age, signature Informed Consent Form also can adhere to therapist according to plan。
1.3.2 exclusion standard: bridegroom's or husband's side semen routine analysis not in normal range, sexual life is abnormal, have endocrine and other immune disease histories；There are endocrine disturbance, abnormal thyroid function and female genital tract deformity in the wife's side；Both sides have toxoplasma, cytomegalovirus, herpes simplex virus, rubella virus infection；Both sides' chromosome karyotype analysis is abnormal；The positives such as wife's side anticardiolipin antibody, antisperm antibody or anti-endometrial antibodies；Couple's hepatic and renal function, electrocardiogram, hematuria routine etc. is shown in obvious exception；Allergic constitution or to multi-medicament allergy sufferers；Do not press predetermined treatment medication, it is impossible to judge that curative effect or data are not congruent and affect the treatment or safety judgement person。
1.4 Therapeutic Method
Treatment group: the capsule of the oral embodiment of the present invention 1 preparation, every day 2 times, each 2-4 grain, takes after meal half an hour, and treatment 3 months is 1 course for the treatment of continuously, checks blocking antibody after 3 months。Practising contraception during treatment, menstrual phase is withdrawn, following the service after clean。
Matched group: adopt spouse's lymphocyte active immunity treatment method。
1.5 observation index: two groups for the treatment of rear enclosed antibody turn sun situation；Two groups of tcm symptoms scoring improvement situation (by degree without, light, in, heavily classification, its corresponding score value respectively 0,1,2,3 points)。Adopt nimodipine method, i.e. integration × 100% before (before treatment integration after integration-treatment)/treatment。
1.6 criterions of therapeutical effect: recovery from illness: blocking antibody three all turns sun, symptom, sign disappear or substantially disappear, and symptom integral reduces >=95%；Effective: blocking antibody three all turns sun, and symptom, sign all have improvement, symptom integral reduces >=70%；Effective: blocking antibody one or two turns sun, and symptom, sign all take a favorable turn, symptom integral reduces >=30%；Invalid: blocking antibody level is not improved as treated front level or lower, symptom and sign, even increase the weight of, symptom integral reduces less than 30%。
1.7 statistical methods: adopt SPSS15.0 statistical software to be calculated。Each numerical value withRepresenting, measurement data adopts t inspection, and enumeration data adopts χ2Inspection, statistically significant for difference with P < 0.05。
2 results
Before and after 2.1 liang of group treatments, TCM symptom score compares: after the treatment for the treatment of group, TCM symptom score is all substantially more less than before treatment, with comparing difference statistically significant (P < 0.01) before treatment, matched group compares with before treatment, no significant difference (P > 0.05)；Comparing between two groups after treatment, treatment group is improving soreness of the waist and knees, and the aspects such as lazy speech of breathing hard are better than matched group, and the minimizing for the treatment of group symptom integral becomes apparent from, difference statistically significant (P < 0.01)。In Table 1。
1 liang of table group treatment before and after TCM symptom score compare (Point)
Note: compare with before treatment, * P < 0.01, compare the same period with matched group,#P < 0.01。
2.2 liang of group lab index compare: treat front two groups of AntiCD3 McAb-BE, anti-CD4-BE, anti-CD8-BE total positives number through inspection, no significant difference (P > 0.05)。After treatment, two groups are all significantly improved (P < 0.01) containing AntiCD3 McAb-BE, anti-CD4-BE, anti-CD8-BE total positives number。Treatment group containing AntiCD3 McAb-BE, anti-CD4-BE, anti-CD8-BE total positives number be better than matched group ((P < 0.05), in Table 2。
Before and after the group treatment of 2 liang of table, blocking antibody number positive compares (example)
The comparisons of 2.3 liang of group Comprehensive Clinical curative effects: treatment group and matched group total effective rate respectively 91.7% and 75.0%, two groups of total effective rate comparing differences statistically significant (P < 0.05), the curative effect for the treatment of group is substantially better than matched group。In Table 3。
The comparison of 3 liang of table group Comprehensive Clinical curative effect
Note: compare with matched group, * P < 0.05。
2.4 safety conditions: after treating 3 months, routine blood test, routine urinalysis, electrocardiogram change without exception before and after treatment group patient treatment, in therapeutic process, vital sign is steadily and without the untoward reaction such as nausea and vomiting, allergy, illustrates that our clinical application is safe and reliable。
Claims (10)
1. the pharmaceutical preparation treating the low mo(u)ld bottom half recurrent abortion of blocking antibody, it is characterised in that by Fructus Psoraleae, Semen Cuscutae, Fructus Pandani tectorii, Radix Triplostegiae Grandiflorae, Radix Syzygii Buxifolii root, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, old come blue or green be that medicinal raw material is made。
2. pharmaceutical preparation as claimed in claim 1, it is characterised in that be made up of the medicinal raw material of following weight: Fructus Psoraleae 8-13 part, Semen Cuscutae 15-20 part, Fructus Pandani tectorii 10-15 part, Radix Triplostegiae Grandiflorae 25-30 part, Radix Syzygii Buxifolii root 8-13 part, Rhizoma Atractylodis Macrocephalae 7-12 part, Radix Codonopsis 10-15 part, Fructus Schisandrae Chinensis 1.5-5 part, Radix Angelicae Sinensis 7-12 part, old next blue or green 10-15 part。
3. pharmaceutical preparation as claimed in claim 1, it is characterised in that be made up of the medicinal raw material of following weight: Fructus Psoraleae 12 parts, Semen Cuscutae 18 parts, Fructus Pandani tectorii 10 parts, Radix Triplostegiae Grandiflorae 25 parts, Radix Syzygii Buxifolii root 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Codonopsis 15 parts, Fructus Schisandrae Chinensis 3 parts, Radix Angelicae Sinensis 10 parts, always next blue or green 12 parts。
4. the pharmaceutical preparation as described in as arbitrary in claim 1-3, it is characterised in that described pharmaceutical preparation can make any pharmaceutically useful dosage form。
5. pharmaceutical preparation as claimed in claim 4, it is characterised in that the dosage form of described pharmaceutical preparation is peroral dosage form。
6. pharmaceutical preparation as claimed in claim 5, it is characterised in that described peroral dosage form is preferably soft capsule, capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum。
7. pharmaceutical preparation as claimed in claim 6, it is characterised in that described peroral dosage form is preferably tablet, capsule or granule。
8. pharmaceutical preparation as claimed in claim 7, it is characterised in that described peroral dosage form is preferably capsule。
9. the arbitrary described pharmaceutical preparation of claim 1-8, it is characterised in that preparation method comprises the steps:
(1) by prescription take Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old come blue or green addition 3～8 times amount 65% ethanol, reflux, extract, twice, each 1～3 hour, filtering, merge twice filtrate, decompression recycling ethanol is to without alcohol taste, continue concentrating under reduced pressure and become dry extract, lyophilization, pulverize to obtain ethanol extraction；
(2) filtering residue after Radix Syzygii Buxifolii root, Radix Angelicae Sinensis, old next blue or green ethanol extraction is merged with Fructus Psoraleae, Semen Cuscutae, Fructus Pandani tectorii, Radix Triplostegiae Grandiflorae, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Fructus Schisandrae Chinensis, add 5～10 times amount water, decoct and extract 1-3 time, each 1～3 hour, merging filtrate, filter, it is concentrated into relative density 1.05-1.10 (60 DEG C of surveys), places to room temperature, add ethanol and make alcohol content reach 30%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filters, and decompression filtrate recycling ethanol is to without alcohol taste, lyophilization, pulverizes to obtain water extract；
(3) by the extract mix homogeneously of step (1)-(2), active constituents of medicine of the present invention is obtained；This composition individually or mixes with pharmaceutically acceptable carrier, makes according to galenic pharmacy routine techniques。
10. claim 1-3 arbitrary described pharmaceutical preparation purposes in the medicine of the preparation treatment low mo(u)ld bottom half recurrent abortion of blocking antibody。
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110146600A (en) * | 2018-02-13 | 2019-08-20 | 国药集团同济堂（贵州）制药有限公司 | The preparation method and its detection method of psoralea corylifolia standard decoction |
-
2016
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Non-Patent Citations (2)
| Title |
|---|
| 应翩 等: "张萍青治疗封闭抗体不足性复发性流产经验", 《浙江中西医结合杂志》 * |
| 鲍文开: "补骨脂有壮肾阳固胎之效", 《中医杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110146600A (en) * | 2018-02-13 | 2019-08-20 | 国药集团同济堂（贵州）制药有限公司 | The preparation method and its detection method of psoralea corylifolia standard decoction |
| CN110146600B (en) * | 2018-02-13 | 2022-04-26 | 国药集团同济堂（贵州）制药有限公司 | Preparation method and detection method of fructus psoraleae standard decoction |
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