CN105267437A - Chinese medical preparation for treating liver and kidney deficiency type primary dysmenorrheal and chloasma - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicine and discloses a Chinese medical preparation for treating liver and kidney deficiency type primary dysmenorrheal and chloasma and a preparing method thereof. The Chinese medical preparation is elaborately prepared from prepared rehmannia roots, glossy privet fruit, fructus lycii, semen cuscutae, pyrola, rhizoma atractylodis macrocephalae, poria cocos, leonurus, Chinese rose flower, ligusticum wallichii, ivy glorybind herb roots and flos hibisci. The medicinal materials are organically combined in a mutually assisting mode to tonify the liver and kidney, regulate qi and blood, promote blood circulation to remove blood stasis and promote qi circulation to relieve pain, so that liver and kidney deficiency type primary dysmenorrheal and chloasma can be treated. Side effects are mild, patient compliance is high, the medicine is convenient to take, and recurrence rate is low.

Description

A kind of Chinese medicine preparation for the treatment of Liver and kidney deficient type primary dysmenorrhea companion chloasma

Technical field

The invention belongs to the field of Chinese medicines, be specifically related to a kind of deficient type primary dysmenorrhea of Liver and kidney for the treatment of and accompany Chinese medicine preparation of chloasma and preparation method thereof.

Background technology

Allly be expert at through front and back or menstrual phase, periodically occur hypogastralgia, falling inflation, companion's soreness of waist or other are uncomfortable, or pain draws the waist bones of the body, even severe pain is fainted, and degree is heavier so that affect live and work quality person and be called dysmenorrhea.Also known as abdominal pain during menstruation.Dysmenorrhea is divided into constitutional and Secondary cases two class, and the former is the dysmenorrhea of genitals without organic disease, and mostly occur 2-3 after menophania or menophania.The latter is the dysmenorrhea caused as endometriosis, pelvic inflammatory disease, cervical stenosis etc. by pelvic cavity organic disease.Show according to domestic sampling survey, in China women, dysmenorrhea incidence rate is more than 30%, and wherein functional person accounts for more than 53%, and dysmenorrhea has a strong impact on worker and accounts for about 13%.Dysmenorrhea one is sick, though non-difficult serious disease, is commonly encountered diseases, and patient is also rather worried.

Modern medicine is thought, uterine hypoplasia, uterus are bent excessively afterwards, pelvic inflammatory disease, endometriosis, endocrine disturbance, Prostaglandin increases in blood, all can cause dysmenorrhea.Doctor trained in Western medicine adopts PGSI to reduce the release of prostaglandin to the treatment of primary disease; Or use gonadal hormone ovulation inhibition, relief of symptoms; Or with the pain relieving of spasmolysis and analgesia medicine pain.Western medicine therapy mostly is relief of symptoms, and existence is cured the symptoms, not the disease, and through the drawback of row recurrence, and side effect is obvious, and clinical practice is very limited.

Modern Chinese medicine is to the cause of disease of dysmenorrhea, pathogenesis has had further elaboration, generally believe that dysmenorrhea morbidity hindered with feelings will, daily life accidentally and the six climate exopathogens factor such as to cause harm relevant, why it shows effect with menstrual cycle, physiological environment again with special before and after menstrual period and menstrual period is relevant, its pathogeny is mainly owing to rushing down excessive through the row front and back sea of blood between menstrual period by being completely full of, QI and blood is contained in fact and suddenly empty, uterus, punching appoints QI and blood change more sharply, be subject to paathogenic factor impact, punching is caused to appoint addiction resistance or cold accumulating in meridian, make QI-blood circulation not smooth, uterus blood flow is obstructed, stagnation of QI and blood may bring about pain or not Rong Ze pain.As for the pathogenic factors of primary disease, the many summaries of modern Chinese medicine are thought, dysmenorrhea morbidity can by stagnation of QI blood addiction, cold coagulation born of the same parents, damp invasion of lower energizer, deficient qi and blood, Liver and kidney deficient etc. caused by.

Chloasma is a kind of there is with face the hyperpigmentary disorders that brown or pitchy patch are feature, is a kind of commonly encountered diseases, frequently-occurring disease, difficult treatment.Modern medicine is thought, its physiological change may be, caused by Progesterone and estrogen increase, be more common in mid trimester of pregnancy; Be more common in genital organ disease, endocrinopathy and chronic disease as chronic gastrointestinal disease, hepatorenal disease; Medicine factor is the most common with oral contraceptive.Other factors such as ultraviolet radiation, thermostimulation, cosmetics improper use etc. all can cause chloasma to be formed.Primary disease belongs to the traditional Chinese medical science " chloasma hepaticum ", " cyasma ", " chloasma " category, thinks many and is lost by depression of liver-QI that bar reaches, strongly fragrant heat-transformation of a specified duration and impairment of YIN blood and cause the qi-blood disharmony or blood stasis face of face; Or impairment caused by overstrain spleen soil, deficiency of both QI and blood can not Rong Ze in face; Or because of deficiency of kidney-QI, kidney water can not on hold and fall ill.It is formed with liver,spleen,kidney three dirty in close relations.

Inventor sums up and thinks that the Etiological pathogenesis that chloasma produces and dysmenorrhea have a lot of similarity, internal organs discord, feelings will, QI and blood, woman's Chong and Ren channel disorder are the basic reasons producing primary dysmenorrhea companion chloasma, theory of Chinese medical science thinks that complexion all has close relationship with internal organs qi and blood prosperity and decline from holding the withered change of profit, positive what is called " has Zhu Neibi shape in outer ", and Chinese medicine primary disease has unique advantage.

Summary of the invention

Inventor is based on theory of Chinese medical science, in conjunction with the cause of disease causing Liver and kidney deficient type primary dysmenorrhea companion chloasma, hammer away, meticulous compatibility, adopt modern crafts, provide a kind of Chinese medicine preparation for the treatment of Liver and kidney deficient type primary dysmenorrhea companion chloasma, it has the double effects of depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling speckle removing, Chong and Ren Meridians regulating pain relieving.

For achieving the above object, the present invention adopts following technical scheme: a kind of Chinese medicine preparation for the treatment of Liver and kidney deficient type primary dysmenorrhea companion chloasma, it is that medicinal raw material is made by Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Fructus Lycii, Semen Cuscutae, Herba Pyrolae, the Rhizoma Atractylodis Macrocephalae, Poria, Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Flos Hibisci.

Preferably, treat a Chinese medicine preparation for Liver and kidney deficient type primary dysmenorrhea companion chloasma, it is by the medicinal raw material elaborate of following weight: Radix Rehmanniae Preparata 10-20 part, Fructus Ligustri Lucidi 20-40 part, Fructus Lycii 20-40 part, Semen Cuscutae 10-20 part, Herba Pyrolae 9-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 10-30 part, Poria 10-30 part, Herba Leonuri 10-20 part, Flos Rosae Chinensis 8-13 part, Rhizoma Chuanxiong 5-10 part, Flos Hibisci 20-40 part.

Further preferably, treat a Chinese medicine preparation for Liver and kidney deficient type primary dysmenorrhea companion chloasma, it is by the medicinal raw material elaborate of following weight: Radix Rehmanniae Preparata 15-20 part, Fructus Ligustri Lucidi 26-34 part, Fructus Lycii 25-30 part, Semen Cuscutae 13-18 part, Herba Pyrolae 11-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 25-30 part, Poria 15-20 part, Herba Leonuri 13-18 part, Flos Rosae Chinensis 8-13 part, Rhizoma Chuanxiong 6-10 part, Flos Hibisci 30-40 part.

Further preferably, treat a Chinese medicine preparation for Liver and kidney deficient type primary dysmenorrhea companion chloasma, it is by the medicinal raw material elaborate of following weight: Radix Rehmanniae Preparata 18 parts, Fructus Ligustri Lucidi 30 parts, Fructus Lycii 25 parts, Semen Cuscutae 15 parts, Herba Pyrolae 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 27 parts, 18 parts, Poria, Herba Leonuri 15 parts, Flos Rosae Chinensis 10 parts, Rhizoma Chuanxiong 8 parts, Flos Hibisci 35 parts.

Inventor thinks that Liver and kidney deficient type primary dysmenorrhea companion patient with chloasma natural endowment element is weak, or voluminous exhaustion due to sexual indulgence is damaged, asthenia of essence and blood, through after sea of blood inanition, punching is appointed, uterus loses in moistening foster, show as menstrual period or through after lower abdomen is continuous has a pain, accompany lumbosacral aching pain, dull through color, the few matter of amount is thin, dizziness and tinnitus; The cloudy weary source of blood of Liver and kidney, on not flourish skin, cause dim complexion, speckle color is brown black.Therefore large invigorating the liver and kidney, take good care of QI and blood, Fang Zhong: the sweet temperature nourishing YIN and supplementing blood of Radix Rehmanniae Preparata, beneficial essence fills out marrow, is monarch drug; Fructus Ligustri Lucidi sweetness and bitterness is cool, replenishing YIN to strengthen the kidney, QI invigorating soothing liver-QI, stimulates the menstrual flow and blood; Fructus Lycii Gan Run, kind flat tonifying kidney-yin is not enough, has lung moistening concurrently, promotes the production of body fluid, QI invigorating; The sweet temperature of Semen Cuscutae, the kidney invigorating nourishing the liver, warming the spleen helps stomach; Herba Pyrolae sweetness and bitterness temperature, invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, and the unlikely the moon of four medicine compatibility YIN nourishing declines, and supporing yang and Yang Wang can be made, add the solid marrow of essence, strengthen the muscle and bone, kind invigorating the liver and kidney.The monarch and his subjects 5 use high invigorating the liver and kidney, Mi Gu granule, nourishing YIN and supplementing blood, are ministerial drug.Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic; Poria is sweet then can tonifying spleen-yin, lightly oozes, and bladder must be supported, and kidney qi is both prosperous; Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) sweetness and bitterness is put down, invigorating spleen to remove dampness, dredging collateral regulating menstruation; Three medicines 5 are burnt with having in spleen reinforcing stomach function regulating benefit, and regulating fluid apssage promoting the circulation of QI machine, helps fortune essence of water and grain, is adjuvant drug.Herba Leonuri: toil is trembled with fear, and enters blood system, can nourish blood in promoting the circulation of blood, and promoting the circulation of blood and do not hinder fresh blood, nourishes blood and not stagnant blood stasis; Flos Hibisci sweetness and bitterness is cool, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, and two property of medicine are cold and cool, can clearing away heat from blood and speckle removing; The sweet temperature of Flos Rosae Chinensis, promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling; The pungent temperature of Rhizoma Chuanxiong, blood-activating and qi-promoting, the up head, lower regulating menstruation water, middle relieving stagnation, QI and blood regulating, the pungent temperature bitter cold of four medicine compatibilities use, invigorate blood circulation and not removing blood stasis, promoting the circulation of blood and just do not hinder, and Flos Rosae Chinensis, Flos Hibisci gently a surname is smooth clearly, easily reaching women's head-ornaments, promoting blood circulation to remove blood stasis speckle removing, promoting the circulation of QI to relieve pain, is also adjuvant drug.Above-mentioned all medicine organic assembling, mutually to assist a ruler in governing a country, enhance this medicine liver and kidney tonifying, take good care of effect of QI and blood, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, thus reach the object of curing Liver and kidney deficient type primary dysmenorrhea companion chloasma.

The pharmaceutical research present situation of the present invention's each medicinal raw material used is as follows:

Radix Rehmanniae Preparata: [nature and flavor] are sweet, tepor.[return through] returns liver, kidney channel.[function cures mainly] nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.

Fructus Ligustri Lucidi: [nature and flavor] sweet, bitter, cold.[return through] returns liver, kidney channel.[function cures mainly] nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision." book on Chinese herbal medicine is new again ": " replenishing YIN to strengthen the kidney, QI invigorating soothing liver-QI.Control lumbago and skelalgia, stimulate the menstrual flow and blood.”

Fructus Lycii: [nature and flavor] are sweet is flat.[return through] returns liver, kidney channel.[function cures mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Bencao Jingshu ": " Fructus Lycii, profit and nourishing doublely can be brought down a fever, and specially in the kidney invigorating, lung moistening, promote the production of body fluid, QI invigorating, be the key medicine of Liver and kidney kidney-YIN being deficient, tired interior-heat tonification.”

Semen Cuscutae: [nature and flavor] are sweet, temperature.[return through] returns liver,kidney,spleen warp.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma." book on Chinese herbal medicine converges and says ": " warming the spleen helps the medicine of stomach also for Semen Cuscutae, the kidney invigorating nourishing the liver.But to mend and not high, temperature and not dry, therefore enter kidney channel, void can be mended, in fact can be in order to, cold can temperature, heat can be cool, wet can be dry, dryly can to moisten.”

Herba Pyrolae: [nature and flavor] are sweet, bitter, temperature.[return through] returns liver, kidney channel.[function cures mainly] wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.[usage and dosage] 9 ~ 15g.Control lumbago due to renal deficiency, deficiency of both the liver and kidney, foot knee joint are unable, Radix Caraganae Sinicae can be coordinated to follow the medicines such as Semen Cuscutae.

Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae): [nature and flavor] sweet micro-hardship; Flat.[return through] liver; Kidney channel.[function cures mainly] spleen invigorating; Dampness removing; Regulating menstruation.Main weakness of the spleen and stomach; Dyspepsia; Infantile milk regurgitation; Infantile malnutrition; Five types of stranguria; Leukorrhagia; Menoxenia.

The Rhizoma Atractylodis Macrocephalae: [nature and flavor] are bitter, sweet, temperature.[return through] returns spleen, stomach warp.[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.

Poria: [nature and flavor] are sweet, light is flat.[return through] GUIXIN, lung, spleen, kidney channel.[function cures mainly] promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Herba Leonuri: [nature and flavor] are bitter, pungent, are slightly cold.[return through] returns liver, pericardium channel.[function cures mainly] promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema." book on Chinese herbal medicine converge with speech ": " Herba Leonuri, promoting the circulation of blood is nourished blood, promoting the circulation of blood and do not hinder fresh blood, nourishes blood and not stagnant blood stasis, be really the panacea of blood man also.”

Flos Rosae Chinensis: [nature and flavor] are sweet; Temperature; Nontoxic.[return through] liver; Kidney channel.[function cures mainly] promoting blood flow to regulate menstruation; Removing toxic substances and promoting subsidence of swelling.Main menoxenia; Dysmenorrhea; Amenorrhea; Traumatic injury; Swelling and pain due to blood stasis; Scrofula; Carbuncle; Scald.

Rhizoma Chuanxiong: [nature and flavor] are pungent, temperature.[return through] returns liver, gallbladder, pericardium channel.[function cures mainly] blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Flos Hibisci: [nature and flavor] are sweet; Bitter; Cool.[return through] spleen; Lung; Liver Channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.Main hemorrhoidal hamorrhage rushes down blood; Red white dysentery; Bleeding hemorrhoids; Cough due to lung-heat; Hemoptysis; Leucorrhea; Furuncle carbuncle; Scald.Use fresh goods in the present invention, if with dry product, its consumption can be the 1/5-1/2 of fresh goods consumption.

In order to express Chinese medicine preparation of the present invention better, Chinese medicine preparation of the present invention is active component by Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Fructus Lycii, Semen Cuscutae, Herba Pyrolae, the Rhizoma Atractylodis Macrocephalae, Poria, Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Flos Hibisci or its water or its extractive with organic solvent, adds medicine acceptable carrier and be prepared from.

Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, preferably peroral dosage form, as: soft capsule, capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum, Chinese medicine preparation preparation further preferably of the present invention is preferably tablet, capsule or granule, and Chinese medicine preparation preparation further preferably of the present invention is preferably capsule.

Chinese medicine preparation of the present invention, applicable medicine acceptable carrier is optionally added when being prepared into medicament, described medicine acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.

The present inventor also finds under study for action, by optimized fabrication method, and can when remaining valid medicine, remove impurity or the part without drug effect, reduce impurity to the interference of therapeutic effect, make this Chinese medicine preparation more effective, and reduce the consumption of medicine thus.Therefore, present invention also offers a kind of method preparing the Chinese medicine preparation for the treatment of Liver and kidney deficient type primary dysmenorrhea companion chloasma, the method comprises the following steps:

(1) Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Flos Hibisci, adds 5-10 times amount 80-95% ethanol (preferred 90-95% ethanol), reflux, extract, twice, each 1-3 hour, filters, merges twice filtrate, decompression recycling ethanol is to without alcohol taste, for subsequent use;

(2) by Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), filtering residue and Radix Rehmanniae Preparata after Flos Hibisci ethanol extraction, Fructus Ligustri Lucidi, Fructus Lycii, Semen Cuscutae, Herba Pyrolae, the Rhizoma Atractylodis Macrocephalae, Poria merges, add 5-10 times of water gaging, decoct extraction 3 times, each 1-3 hour, merging filtrate, filter, be concentrated into relative density 1.20-1.25 (60 DEG C of surveys), be placed to room temperature, adding ethanol makes alcohol content reach 50-55%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, merge with above-mentioned clear paste, mix homogeneously, drying under reduced pressure is to dry, obtain active constituents of medicine, this composition is independent or mix with medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to galenic pharmacy routine techniques.

Preparation of the present invention is in use according to the situation determination usage and dosage of patient.Preparation of the present invention according to the situation determination usage and dosage of patient, can take 1-3 time in use every day, each 1-20 agent, as: 1-20 bag or grain or sheet.

The present invention is that inventor is through repeatedly studying, progressively improve, last successful a kind of curative effect treats the medicine of Liver and kidney deficient type primary dysmenorrhea companion chloasma preferably, and logical clinical observation test demonstrates the therapeutic effect of Chinese medicine preparation of the present invention to Liver and kidney deficient type primary dysmenorrhea companion chloasma further, particulars is as described below:

1 data and method

1.1 physical data: carry out Liver and kidney deficient type primary dysmenorrhea companion patient with chloasma 114 example that my institute accepts for medical treatment during being chosen in March ,-2014 in January, 2013, the course of disease 3 months ~ 12 years, pain time continues 2h ~ 5d.Patient is divided into two groups at random, often organizes 57 people, 18 ~ 37 years old treatment group mean age, average (24.7 ± 6.5) year, average course of disease (2.8 ± 2.6) year; 18 ~ 39 years old matched group age, average (25.5 ± 7.1) year, average course of disease (3.2 ± 2.8) year.Two groups of physical data are through statistical procedures difference nonsignificance (P > 0.05), two groups of patients there was no significant difference (P > 0.05) in the physical data such as size and color intensity of age, the course of disease, pain time, pain degree and mottle, has comparability.

1.2 diagnostic criterias: " diagnosis basis of disease of tcm Standardization of diagnosis and curative effect-dysmenorrhea " that " clinical diagnosis of chloasma and criterion of therapeutical effect " (2003 revised draft) formulated with reference to Dermatology Professional Committee of CAIM (Chinese Association Of Integrative Medicine) pigment disease group and State Administration of Traditional Chinese Medicine promulgate.

Inclusion criteria: meet chloasma Western medicine diagnose, the deficient type tcm diagnosis of primary dysmenorrhea Liver and kidney, age at 18 years old ~ 40 years old.Exclusion standard: get rid of gestation, the chloasma that hysteromyoma, freckle, Addison's disease, all kinds of hepatitis, thyroid disease, malignant tumor, contraceptive cause and can not adhering to is taken medicine.

1.3 Therapeutic Method:

Treatment group: capsule prepared by the embodiment of the present invention 1, can subtract clothes during menstrual onset or withdraw, once take 2-4 grain, one day 2 times, continuous use 3 menstrual cycle are a course for the treatment of.2 courses for the treatment of judge curative effect.

Matched group: six drugs containing rehmanniae concentrated pill for oral use, can subtract clothes or withdraw, once taking 8-12 ball, within one day, take 3 times during menstrual onset; Add VITAMIN C TABLET 200mg, vitamin E soft capsule 100mg equal every day three times, 3 menstrual cycle were 1 course for the treatment of simultaneously.2 courses for the treatment of judge curative effect.

1.4 curative effect determinate standards: about the criterion of therapeutical effect of dysmenorrhea and with reference to the criterion of therapeutical effect about chloasma in " clinical diagnosis of chloasma and criterion of therapeutical effect " (2003 revised draft) of Dermatology Professional Committee of CAIM (Chinese Association Of Integrative Medicine) pigment disease group formulation in " Chinese medical disease Standardization of diagnosis and curative effect " that reference State Administration of Traditional Chinese Medicine promulgates.Recovery from illness: patient's dysmenorrhea phenomenon disappears, and naked eyes disappear depending on mottle area and are more than or equal to 90%, and color disappears substantially, and continuous 3 menstrual cycle have no recurrence.Effective: stomachache obviously alleviates, all the other symptoms take a turn for the better, and naked eyes disappear 60% ~ 89% depending on mottle area, and color is obviously thin out, and continuous 3 menstrual cycle have no recurrence.Take a turn for the better: stomachache alleviates, all the other symptoms take a turn for the better, and naked eyes look mottle area 30% ~ 59%, and color is thin out, but can not maintain more than 3 months.Invalid: stomachache and other symptoms are without change, and naked eyes are less than 30% depending on mottle area, and color is without significant change or increase the weight of on the contrary.

1.5 statistical methods: adopt SPSS16.0 statistical software to calculate.Each numerical value with represent, measurement data adopts t inspection, and enumeration data adopts χ ²inspection, with P < 0.05 for difference has statistical significance.

2 results

2.1 liang of group therapeutic effect compare: after two courses for the treatment of, treatment group recovery from illness 33 example, effective 17 examples, and take a turn for the better 7 examples, invalid 0 example, obvious effective rate 87.7%, total effective rate 100%; Matched group recovery from illness 11 example, effective 17 examples, take a turn for the better 13 examples, invalid 16 examples, obvious effective rate 49.1%, total effective rate 71.9%, treatment group obvious effective rate, total effective rate are apparently higher than matched group, and difference has statistical significance (P < 0.05).Concrete outcome is in table 1.

A table 1 liang group therapeutic effect compares

Group	Number	Recovery from illness	Effective	Take a turn for the better	Invalid	Obvious effective rate %	Total effective rate %
								Treatment group	57	33	17	7	0	87.7％	100％
Matched group	57	11	17	13	16	49.1％	71.9％

2.2 liang of group Patients on Recurrence situations compare: follow the tracks of and follow up a case by regular visits to 1 year, and treatment group follows up a case by regular visits to 55 examples, and matched group follows up a case by regular visits to 50 examples, and two groups of relapse rates compare that there were significant differences (P < 0.05), and each group recurrence is in table 2.

A table 2 liang group Patients on Recurrence situation compares

Group	Follow up a case by regular visits to number	Recurrence number	Relapse rate
				Treatment group	55	3	5.5％
Matched group	50	28	56％

In a word, Chinese medicine preparation of the present invention significantly can improve the symptom of Liver and kidney deficient type primary dysmenorrhea companion chloasma, compared with matched group, the obvious effective rate of Chinese medicine preparation treatment group of the present invention, total effective rate are apparently higher than matched group, and difference has statistical significance (P < 0.05), follow up a case by regular visits to 1 year, Patients on Recurrence rate is also starkly lower than matched group.

Compared with prior art beneficial effect of the present invention is: selected by medicine of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, legislation comprehensively, medication is thoughtful, play liver and kidney tonifying altogether, take good care of QI and blood, blood circulation promoting and blood stasis dispelling, effect of promoting the circulation of QI to relieve pain, for the multiple paathogenic factor of Liver and kidney deficient type primary dysmenorrhea companion chloasma, play Chinese medicine preparation Mutiple Targets of the present invention, too many levels, multi-level comprehensive regulation effect, link up up and down, clinical efficacy is definite, side effect is less, patient compliance is better, taking convenience, relapse rate is lower, can effectively alleviate patient's burden and misery, the object for the treatment of both the principal and secondary aspects of a disease can be reached, wide popularization and application on clinic.

Detailed description of the invention

Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.

Embodiment 1

Prescription: Radix Rehmanniae Preparata 18 parts, Fructus Ligustri Lucidi 30 parts, Fructus Lycii 25 parts, Semen Cuscutae 15 parts, Herba Pyrolae 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 27 parts, 18 parts, Poria, Herba Leonuri 15 parts, Flos Rosae Chinensis 10 parts, Rhizoma Chuanxiong 8 parts, Flos Hibisci 35 parts.

Preparation method: (1) Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Flos Hibisci, adds 5-10 times amount 90% ethanol, reflux, extract, twice, each 1-3 hour, filters, merges twice filtrate, and decompression recycling ethanol is to without alcohol taste, for subsequent use;

(2) by Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), filtering residue and Radix Rehmanniae Preparata after Flos Hibisci ethanol extraction, Fructus Ligustri Lucidi, Fructus Lycii, Semen Cuscutae, Herba Pyrolae, the Rhizoma Atractylodis Macrocephalae, Poria merges, add 5-10 times of water gaging, decoct extraction 3 times, each 1-3 hour, merging filtrate, filter, be concentrated into relative density 1.23 (60 DEG C of surveys), be placed to room temperature, adding ethanol makes alcohol content reach 55%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, merge with above-mentioned clear paste, mix homogeneously, drying under reduced pressure is to dry, pulverize, granulate, incapsulate shell and obtain 100.

Embodiment 2

Prescription: Radix Rehmanniae Preparata 18 parts, Fructus Ligustri Lucidi 30 parts, Fructus Lycii 25 parts, Semen Cuscutae 15 parts, Herba Pyrolae 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 27 parts, 18 parts, Poria, Herba Leonuri 15 parts, Flos Rosae Chinensis 10 parts, Rhizoma Chuanxiong 8 parts, Flos Hibisci 35 parts.

Preparation method: (1) Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Flos Hibisci, adds 5-10 times amount 95% ethanol, reflux, extract, twice, each 1-3 hour, filters, merges twice filtrate, and decompression recycling ethanol is to without alcohol taste, for subsequent use;

(2) by Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), filtering residue and Radix Rehmanniae Preparata after Flos Hibisci ethanol extraction, Fructus Ligustri Lucidi, Fructus Lycii, Semen Cuscutae, Herba Pyrolae, the Rhizoma Atractylodis Macrocephalae, Poria merges, add 5-10 times of water gaging, decoct extraction 3 times, each 1-3 hour, merging filtrate, filter, be concentrated into relative density 1.20 (60 DEG C of surveys), be placed to room temperature, adding ethanol makes alcohol content reach 50%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, merge with above-mentioned clear paste, mix homogeneously, drying under reduced pressure is to dry, pulverize, granulate, incapsulate shell and obtain 100.

Embodiment 3

Prescription: Radix Rehmanniae Preparata 18 parts, Fructus Ligustri Lucidi 30 parts, Fructus Lycii 25 parts, Semen Cuscutae 15 parts, Herba Pyrolae 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 27 parts, 18 parts, Poria, Herba Leonuri 15 parts, Flos Rosae Chinensis 10 parts, Rhizoma Chuanxiong 8 parts, Flos Hibisci 35 parts.

Preparation method: (1) Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Flos Hibisci, adds 5-10 times amount 92% ethanol, reflux, extract, twice, each 1-3 hour, filters, merges twice filtrate, and decompression recycling ethanol is to without alcohol taste, for subsequent use;

(2) by Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), filtering residue and Radix Rehmanniae Preparata after Flos Hibisci ethanol extraction, Fructus Ligustri Lucidi, Fructus Lycii, Semen Cuscutae, Herba Pyrolae, the Rhizoma Atractylodis Macrocephalae, Poria merges, add 5-10 times of water gaging, decoct extraction 3 times, each 1-3 hour, merging filtrate, filter, be concentrated into relative density 1.25 (60 DEG C of surveys), be placed to room temperature, adding ethanol makes alcohol content reach 52%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, merge with above-mentioned clear paste, mix homogeneously, drying under reduced pressure is to dry, pulverize, granulate, incapsulate shell and obtain 100.

Embodiment 4

Prescription: Radix Rehmanniae Preparata 18 parts, Fructus Ligustri Lucidi 30 parts, Fructus Lycii 25 parts, Semen Cuscutae 15 parts, Herba Pyrolae 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 27 parts, 18 parts, Poria, Herba Leonuri 15 parts, Flos Rosae Chinensis 10 parts, Rhizoma Chuanxiong 8 parts, Flos Hibisci 35 parts.

Preparation method: (1) Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Flos Hibisci, adds 5-10 times amount 85% ethanol, reflux, extract, twice, each 1-3 hour, filters, merges twice filtrate, and decompression recycling ethanol is to without alcohol taste, for subsequent use;

(2) by Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), filtering residue and Radix Rehmanniae Preparata after Flos Hibisci ethanol extraction, Fructus Ligustri Lucidi, Fructus Lycii, Semen Cuscutae, Herba Pyrolae, the Rhizoma Atractylodis Macrocephalae, Poria merges, add 5-10 times of water gaging, decoct extraction 3 times, each 1-3 hour, merging filtrate, filter, be concentrated into relative density 1.22 (60 DEG C of surveys), be placed to room temperature, adding ethanol makes alcohol content reach 50%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, merge with above-mentioned clear paste, mix homogeneously, drying under reduced pressure is to dry, pulverize, granulate, incapsulate shell and obtain 100.

Embodiment 5

Prescription: Radix Rehmanniae Preparata 15 parts, Fructus Ligustri Lucidi 34 parts, Fructus Lycii 28 parts, Semen Cuscutae 13 parts, Herba Pyrolae 15 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 25 parts, 15 parts, Poria, Herba Leonuri 15 parts, Flos Rosae Chinensis 12 parts, Rhizoma Chuanxiong 6 parts, Flos Hibisci 35 parts.

Preparation method: reference example 1-4.

Embodiment 6

Prescription: Radix Rehmanniae Preparata 20 parts, Fructus Ligustri Lucidi 30 parts, Fructus Lycii 25 parts, Semen Cuscutae 15 parts, Herba Pyrolae 12 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 20 parts, 20 parts, Poria, Herba Leonuri 12 parts, Flos Rosae Chinensis 8 parts, Rhizoma Chuanxiong 6 parts, Flos Hibisci 30 parts.

Preparation method: reference example 1-4.

Embodiment 7

Prescription: Radix Rehmanniae Preparata 15 parts, Fructus Ligustri Lucidi 25 parts, Fructus Lycii 25 parts, Semen Cuscutae 15 parts, Herba Pyrolae 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 15 parts, 15 parts, Poria, Herba Leonuri 15 parts, Flos Rosae Chinensis 10 parts, Rhizoma Chuanxiong 6 parts, Flos Hibisci 35 parts.

Preparation method: reference example 1-4.

Embodiment 8

Prescription: Radix Rehmanniae Preparata 15 parts, Fructus Ligustri Lucidi 26 parts, Fructus Lycii 30 parts, Semen Cuscutae 18 parts, Herba Pyrolae 11 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 25 parts, 17 parts, Poria, Herba Leonuri 15 parts, Flos Rosae Chinensis 10 parts, Rhizoma Chuanxiong 10 parts, Flos Hibisci 30 parts.

Preparation method: reference example 1-4.

Embodiment 9

Prescription: Radix Rehmanniae Preparata 18 parts, Fructus Ligustri Lucidi 30 parts, Fructus Lycii 25 parts, Semen Cuscutae 15 parts, Herba Pyrolae 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 27 parts, 18 parts, Poria, Herba Leonuri 15 parts, Flos Rosae Chinensis 10 parts, Rhizoma Chuanxiong 8 parts, Flos Hibisci 35 parts.

Preparation method: (1) Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Flos Hibisci, adds 5-10 times amount 90% ethanol, reflux, extract, twice, each 1-3 hour, filters, merges twice filtrate, and decompression recycling ethanol is to without alcohol taste, for subsequent use;

(2) by Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), filtering residue and Radix Rehmanniae Preparata after Flos Hibisci ethanol extraction, Fructus Ligustri Lucidi, Fructus Lycii, Semen Cuscutae, Herba Pyrolae, the Rhizoma Atractylodis Macrocephalae, Poria merges, add 5-10 times of water gaging, decoct extraction 3 times, each 1-3 hour, merging filtrate, filter, be concentrated into relative density 1.24 (60 DEG C of surveys), be placed to room temperature, adding ethanol makes alcohol content reach 55%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, merge with above-mentioned clear paste, mix homogeneously, drying under reduced pressure is to dry, pulverize, add appropriate amount of auxiliary materials mixing, tabletting, obtain.

Embodiment 10

Prescription: Radix Rehmanniae Preparata 18 parts, Fructus Ligustri Lucidi 30 parts, Fructus Lycii 25 parts, Semen Cuscutae 15 parts, Herba Pyrolae 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 27 parts, 18 parts, Poria, Herba Leonuri 15 parts, Flos Rosae Chinensis 10 parts, Rhizoma Chuanxiong 8 parts, Flos Hibisci 35 parts.

Preparation method: (1) Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Flos Hibisci, adds 5-10 times amount 93% ethanol, reflux, extract, twice, each 1-3 hour, filters, merges twice filtrate, and decompression recycling ethanol is to without alcohol taste, for subsequent use;

(2) by Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), filtering residue and Radix Rehmanniae Preparata after Flos Hibisci ethanol extraction, Fructus Ligustri Lucidi, Fructus Lycii, Semen Cuscutae, Herba Pyrolae, the Rhizoma Atractylodis Macrocephalae, Poria merges, add 5-10 times of water gaging, decoct extraction 3 times, each 1-3 hour, merging filtrate, filter, be concentrated into relative density 1.20 (60 DEG C of surveys), be placed to room temperature, adding ethanol makes alcohol content reach 50%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, merge with above-mentioned clear paste, mix homogeneously, drying under reduced pressure is to dry, pulverize, granulate, pack and get final product.

Claims (9)

1. treat a Chinese medicine preparation for Liver and kidney deficient type primary dysmenorrhea companion chloasma, it is characterized in that by Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Fructus Lycii, Semen Cuscutae, Herba Pyrolae, the Rhizoma Atractylodis Macrocephalae, Poria, Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Flos Hibisci be medicinal raw material elaborate.

2. Chinese medicine preparation as claimed in claim 1, is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: Radix Rehmanniae Preparata 10-20 part, Fructus Ligustri Lucidi 20-40 part, Fructus Lycii 20-40 part, Semen Cuscutae 10-20 part, Herba Pyrolae 9-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 10-30 part, Poria 10-30 part, Herba Leonuri 10-20 part, Flos Rosae Chinensis 8-13 part, Rhizoma Chuanxiong 5-10 part, Flos Hibisci 20-40 part.

3. Chinese medicine preparation as claimed in claim 2, is characterized in that being made up of the medicinal raw material of following weight: Radix Rehmanniae Preparata 15-20 part, Fructus Ligustri Lucidi 26-34 part, Fructus Lycii 25-30 part, Semen Cuscutae 13-18 part, Herba Pyrolae 11-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 25-30 part, Poria 15-20 part, Herba Leonuri 13-18 part, Flos Rosae Chinensis 8-13 part, Rhizoma Chuanxiong 6-10 part, Flos Hibisci 30-40 part.

4. Chinese medicine preparation as claimed in claim 3, is characterized in that being made up of the medicinal raw material of following weight: Radix Rehmanniae Preparata 18 parts, Fructus Ligustri Lucidi 30 parts, Fructus Lycii 25 parts, Semen Cuscutae 15 parts, Herba Pyrolae 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 27 parts, 18 parts, Poria, Herba Leonuri 15 parts, Flos Rosae Chinensis 10 parts, Rhizoma Chuanxiong 8 parts, Flos Hibisci 35 parts.

5. the Chinese medicine preparation as described in as arbitrary in claim 1-4, is characterized in that described Chinese medicine preparation is peroral dosage form.

6. Chinese medicine preparation as claimed in claim 5, is characterized in that described peroral dosage form is preferably soft capsule, capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum.

7. Chinese medicine preparation as claimed in claim 6, is characterized in that described peroral dosage form is capsule, tablet, granule.

8. the Chinese medicine preparation as described in as arbitrary in claim 1-4, it is characterized in that described Chinese medicine preparation is active component by Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Fructus Lycii, Semen Cuscutae, Herba Pyrolae, the Rhizoma Atractylodis Macrocephalae, Poria, Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Flos Hibisci or its water or its extractive with organic solvent, add medicine acceptable carrier and be prepared from.

9. the Chinese medicine preparation as described in as arbitrary in claim 1-8, is characterized in that the preparation method of described Chinese medicine preparation comprises the following steps:

(1) Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Flos Hibisci, adds 5-10 times amount 80-95% ethanol (preferred 90-95% ethanol), reflux, extract, twice, each 1-3 hour, filters, merges twice filtrate, decompression recycling ethanol is to without alcohol taste, for subsequent use;

(2) by Herba Leonuri, Flos Rosae Chinensis, Rhizoma Chuanxiong, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), filtering residue and Radix Rehmanniae Preparata after Flos Hibisci ethanol extraction, Fructus Ligustri Lucidi, Fructus Lycii, Semen Cuscutae, Herba Pyrolae, the Rhizoma Atractylodis Macrocephalae, Poria merges, add 5-10 times of water gaging, decoct extraction 3 times, each 1-3 hour, merging filtrate, filter, be concentrated into relative density 1.20-1.25 (60 DEG C of surveys), be placed to room temperature, adding ethanol makes alcohol content reach 50-55%, stir evenly,-5-0 DEG C of cold preservation 12 hours, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, merge with above-mentioned clear paste, mix homogeneously, drying under reduced pressure is to dry, obtain active constituents of medicine, this composition is independent or mix with medicine acceptable carrier, makes Chinese medicine preparation of the present invention according to galenic pharmacy routine techniques.