CN103656460B - A kind of Chinese medicine composition for the treatment of diabetes - Google Patents

A kind of Chinese medicine composition for the treatment of diabetes Download PDF

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CN103656460B
CN103656460B CN201310704612.4A CN201310704612A CN103656460B CN 103656460 B CN103656460 B CN 103656460B CN 201310704612 A CN201310704612 A CN 201310704612A CN 103656460 B CN103656460 B CN 103656460B
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radix
diabetes
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fructus
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CN103656460A (en
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姚世新
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Yao Shixin
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Abstract

The invention discloses a kind of Chinese medicine composition for the treatment of diabetes, belong to the field of Chinese medicines.It is made up of following raw material medicaments: Concha Ostreae, Radix Polygoni Multiflori, Cortex Lycii, Radix Rehmanniae, the Radix Aucklandiae, Radix Achyranthis Bidentatae, Poria, Rhizoma Chuanxiong, Cortex Moutan, Os Draconis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Rhizoma Alismatis, Fructus Corni, Radix Codonopsis, Semen Cuscutae, Fructus Amomi and Radix Glycyrrhizae.The present invention has that dehumidifying, heat clearing away, change are turbid, the effect of removing toxic substances, effectively can suppress the development of diabetes, improve patients symptomatic, sign, and without obvious toxic-side effects.

Description

A kind of Chinese medicine composition for the treatment of diabetes
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of diabetes, belong to technical field of Chinese medicines.
Background technology
Diabetes be due to insulin secretion in body relatively or definitely not enough and cause sugar, fat and protein obstacle, the disease that it is is feature with polydipsia, polyphagia, polyuria, lean body mass.Along with the raising of people's living standard, the sickness rate of diabetes is increasing year by year.The prevalence of developed country's diabetes is up to 5-10%, and the prevalence of China reaches 3%.Diabetes clinical manifestation is that blood glucose raises, glucose in urine is positive and carbohydrate tolerance reduces, classical symptom is polydipsia, polyuria, polyphagia, become thin, dizzy and weak, extend with the course of disease, occur with a series of complication, complication is the key factor causing diabetics death.Research confirms viral infection, obesity, environmental factors, heredity all possibility induced Diabetic, in addition pregnancy durations, and estrogen increases, and causes islet p-cell destruction, also can induced Diabetic.
Present treatment diabetes many employings Western medicine metformin, take Western medicine damage liver, kidney for a long time, stimulating gastrointestinal road, the side effect brought allows patient suffer untold misery.Pure Chinese medicinal preparation of the present invention, can fundamentally eliminate diabetes and complication, improve the quality of living, and removes diabetes long-term taking Western medicine, the clinical drawback of Tighter control.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of diabetes, it overcomes the deficiency of existing medicine, can treat diabetes fast, thoroughly.
Technical scheme of the present invention is: a kind of Chinese medicine composition for the treatment of diabetes, is characterized in that, is made up of the crude drug of following weight: Concha Ostreae 15-25 gram, Radix Polygoni Multiflori 15-25 gram, Cortex Lycii 15-25 gram, Radix Rehmanniae 15-25 gram, Radix Aucklandiae 10-20 gram, Radix Achyranthis Bidentatae 10-20 gram, Poria 10-20 gram, Radix Paeoniae Rubra 10-20 gram, Rhizoma Chuanxiong 10-20 gram, Cortex Moutan 10-20 gram, Os Draconis 10-20 gram, Radix Ophiopogonis 5-15 gram, Fructus Schisandrae Chinensis 5-15 gram, Rhizoma Alismatis 5-15 gram, Fructus Corni 5-15 gram, Radix Codonopsis 5-15 gram, Semen Cuscutae 5-15 gram, Fructus Amomi 3-6 gram, Radix Glycyrrhizae 5-12 gram.
The further technical scheme of the present invention is: a kind of Chinese medicine composition for the treatment of diabetes, is characterized in that, is made up of the crude drug of following weight: Concha Ostreae 20 grams, Radix Polygoni Multiflori 20 grams, Cortex Lycii 20 grams, Radix Rehmanniae 20 grams, the Radix Aucklandiae 15 grams, Radix Achyranthis Bidentatae 15 grams, 15 grams, Poria, Radix Paeoniae Rubra 15 grams, Rhizoma Chuanxiong 15 grams, Cortex Moutan 15 grams, Os Draconis 15 grams, Radix Ophiopogonis 10 grams, Fructus Schisandrae Chinensis 10 grams, Rhizoma Alismatis 10 grams, Fructus Corni 10 grams, Radix Codonopsis 10 grams, Semen Cuscutae 10 grams, Fructus Amomi 6 grams, 6 grams, Radix Glycyrrhizae.
Preparation and instructions of taking: raw material is mixed in marmite, adds water and soak in right amount; First intense fire is fried boiling, then with half an hour at a simmer, leaches medicinal liquid, adds water and again decoct half an hour in right amount, then leach medicinal liquid in medicinal residues.Twice medicinal liquid mixes, cools completely, and respectively at half an hour before breakfast, within after supper two hours, takes.
The pharmacological action of each Chinese medicine:
Concha Ostreae: yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, arresting seminal emission, reduces phlegm, softening the hard mass.Control dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.
Fructus Corni: invigorating the liver and kidney, arresting seminal emission gas, Gu collapse.Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat.
Radix Polygoni Multiflori: bitter sweet puckery, tepor.Enter liver, kidney channel.Tonifying liver, kidney tonifying, nourishes blood, and dispels the wind.Control hepatic and renal YIN deficiency, sending out must be early white, and blood deficiency is dizzy, and waist knee joint is weak, and muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.
Cortex Lycii: heat clearing away, removing heat from blood, controls asthenia hectic fever night sweat, lung-heat cough with asthma, carbuncle malignant boil.
Radix Rehmanniae: clearing up internal heat by using drugs of bitter in taste and cold in nature, Gan Hanzhi moistens yin nourishing, is the refrigerant product moistened, is good at nourishing YIN and clearing away heat removing heat from blood.Effect clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, intestine moistening.
The Radix Aucklandiae: gas fragrance, taste is sweet, bitter, slightly stings tongue.Warm in nature, acrid in the mouth, hardship.Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For weighing after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia.
Radix Achyranthis Bidentatae: sweetness and bitterness acid is flat.Enter liver, kidney channel.Life uses dissipating blood stasis blood, subduing inflammation.Control gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury.Ripe invigorating the liver and kidney, bone and muscle strengthening.Control waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.
Poria: sweet light is flat.Enter the heart, spleen, lung meridian.Eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.
Radix Paeoniae Rubra: bitter in the mouth is flat.Enter liver, spleen channel.Clots absorbing, pain relieving, removing heat from blood, detumescence.Control the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle.
Rhizoma Chuanxiong: acrid in the mouth, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Cortex Moutan: heat clearing away, removing heat from blood, and blood, repercussive.Control the pathogenic heat attacking blood system in febrile diseases, send out speckle, infantile convulsion, tells, is defeated in battle, has blood in stool, hectic fever due to YIN-deficiency consumptive fever, and amenorrhea ， mass in the abdomen, carbuncle and ulcer, flutters damage.
Os Draconis: tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, insomnia and dreamful sleep, spontaneous sweating, seminal emission stranguria with turbid discharge, tells nosebleed and has blood in stool, bleeding not during menses, dysentery proctoptosis.
Radix Ophiopogonis: sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.
Fructus Schisandrae Chinensis: acid, temperature.Enter lung, kidney channel, astringe the lung, nourishing kidney, promote the production of body fluid, receive antiperspirant, arresting seminal emission.Control the deficiency of the lung to breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.
Rhizoma Alismatis: sweet, cold.Enter kidney, urinary bladder channel.Diuretic, eliminating dampness by diuresis, expels the heat-evil.Control dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.
Fructus Corni: invigorating the liver and kidney, arresting seminal emission gas, Gu collapse.Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse.
Radix Codonopsis: sweet is flat.Start with, meridian of Foot-TAI YIN edema caused by disorder of QI.Invigorating the spleen and replenishing QI, promotes the production of body fluid, and nourishes blood.The empty asthenia of body for deficiency of QI in middle-JIAO, weakness of the spleen and stomach, deficiency of both QI and blood, controls fatigue and lack of strength, lung qi virtual loss.Control lack of appetite, thirsty, chronic diarrhea, proctoptosis.And the two shallow complexion of losing of QI and blood, dizzy cardiopalmus etc.
Semen Cuscutae: tonifying liver pain, beneficial marrow, improving eyesight.Control soreness of waist and knee joint, quench one's thirst, order is dark.
Fructus Amomi: pungent, temperature.Enter spleen, stomach warp.During circulation of qi promoting is adjusted, stomach function regulating, is amusing.Control stomachache painful abdominal mass swollen, anorexia dyspepsia, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery, pregnant fetal movement.
Chinese medicine is thought, with the passing of time diabetes, must sap one's vitality, deficiency of both QI and YIN, and it is unable that the deficiency of vital energy then transports blood, and deficiency of YIN person's blood is involved and abstruse forms the kidney usually involved in chronic disease, the blood stasis syndrome of pathogen usually intruding into collateral in protracted disease.Treatment is attacked parallel when benefit, getting rid of evils when noticing that dehumidifying, heat clearing away, change are turbid, removing toxic substances, especially will pay attention to the application of blood circulation promoting and blood stasis dispelling principle in this disease is treated.
Below in conjunction with clinical data and model case, beneficial effect of the present invention is further illustrated.
One, clinical observation
1, clinical data: be selected from the outpatient service in year May in June, 2011 to 2013 and inpatient totally 92 examples, the age be 38-69 year, average 54.5 years old.
2, diagnostic criteria:
(1) diabetic symptom (polyuria, polydipsia and inexplicable weight loss) is had, and random (any time after the meal) plasma glucose >=11.1mmol/L (200mg/dl);
(2) or on an empty stomach (fasting at least 8 hours) plasma glucose >=7.0mmol/L (126mg/dl);
Or OGTT2 hour plasma glucose >=11.1mmol/L (200mg/dl) (3)
Fasting glucose damage (IFG): refer to fasting plasma glucose >=6.1mmol/L (110mg/dl), but <7.0mmol/L (126mg/dl).
Impaired glucose tolerance (IGT): refer to OGTT2 hour plasma glucose >=7.8mmol/L (140mg/dl), but <11.1mmol/L (200mg/dl).
3, Therapeutic Method: take medicine of the present invention, soak by water, takes at twice sooner or later.It within 1 month, is 1 course for the treatment of.
4, efficacy assessment standard:
Effective: after treatment, symptom disappears substantially, fasting glucose < 7.2mmol/L, (130mg/dl), 2 hours blood glucose < 8.3mmol/L(150mg/dl after the meal), twenty-four-hour urine sugar total amount < 10.0g, or blood glucose, twenty-four-hour urine sugar total amount decline more than 30% before comparatively treating.
Effective: after treatment, symptom is obviously improved, fasting glucose < 8.3mmol/L(150mg/dl), 2 hours blood glucose < 10.0mmol/L(180mg/dl after the meal), twenty-four-hour urine sugar total amount < 25.0g, or blood glucose, twenty-four-hour urine sugar total amount decline more than 10% before comparatively treating.
Invalid: after treatment, symptom is not improved, blood glucose, glucose in urine decline and do not reach above-mentioned standard.
5, therapeutic outcome: observe 92 routine diabeticss, effective 84 examples, effective 6 examples, invalid 2 examples.Effective percentage is 91.3%.
6, toxic and side effects analysis
In the 92 routine patients observed, only have 2 examples to occur laxativeness, occur that the probability of side reaction is only 2.0% after taking Chinese medicine of the present invention, dispose side reaction through suiting the medicine to the illness and disappear, all the other are without any side effects.
In sum, the present invention is used for the treatment of the Chinese medicine composition of diabetes, through clinical trial, shows its development that effectively can suppress diabetes to improve patients symptomatic, sign, and without obvious toxic-side effects.
Two, model case
Example 1: Liu Lili, female, 47 years old.Suffer from diabetes for many years, once took the treatment of various antidiabetic drug, poor effect, the state of an illness is serious day by day, existing disease: xerostomia, sweating due to debility, biped are sent out cool, lower limbs edema.Once with light time heavy when Western medicine and treatment by Chinese herbs.After clothes we treat two courses for the treatment of, spirit, complexion take a turn for the better, and above-mentioned symptom disappears, and edema disappears.After treatment was fully recovered after one month.
Example 2: Guo Mingliang, man, 61 years old.Diabetes mellitus 3 years, polyorexia, thirsty polydipsia, emaciated physique, through diet control and take glyburide and metformin, blood glucose maintains between 10.1-15.2mmol/l, glucose in urine (+++)-(++++), ketoboidies (++), recently aggravation, starts to control with insulin, takes two courses for the treatment of of we, successively decrease insulin dosage gradually, continue to take medicine insulin of stopping using after two courses for the treatment of, and blood glucose remains between 6.2-7.4mmol/l, glucose in urine (-), continue to strengthen after treating half a year, be in a good state of health.
Example 3: Sun Mingai, female, 45 years old.Diabetes are found 5 years.Self-induction is weak, poor appetite, loose stool, polydipsia, polyuria.Take blood sugar lowering western medicine, heavy time light during symptom, glycemic control is undesirable always.In starting insulin injection treatment the year before.1 course for the treatment of of rear use we treatment, weak disappearance, two is just normal, continues to strengthen 3 courses for the treatment of of medication, check kidney series: urine Alb1027mg/L, urine IgG330mg/L, and patient mental, diet, two are just normal.
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine composition for the treatment of diabetes, is made up of the crude drug of following weight: Concha Ostreae 20 grams, Radix Polygoni Multiflori 20 grams, Cortex Lycii 20 grams, Radix Rehmanniae 20 grams, the Radix Aucklandiae 15 grams, Radix Achyranthis Bidentatae 15 grams, 15 grams, Poria, Radix Paeoniae Rubra 15 grams, Rhizoma Chuanxiong 15 grams, Cortex Moutan 15 grams, Os Draconis 15 grams, Radix Ophiopogonis 10 grams, Fructus Schisandrae Chinensis 10 grams, Rhizoma Alismatis 10 grams, Fructus Corni 10 grams, Radix Codonopsis 10 grams, Semen Cuscutae 10 grams, Fructus Amomi 6 grams, 6 grams, Radix Glycyrrhizae.
Preparation and instructions of taking: raw material is mixed in marmite, adds water and soak in right amount; First intense fire is fried boiling, then with half an hour at a simmer, leaches medicinal liquid, adds water and again decoct half an hour in right amount, then leach medicinal liquid in medicinal residues.Twice medicinal liquid mixes, cools completely, and respectively at half an hour before breakfast, within after supper two hours, takes.
Embodiment 2: a kind of Chinese medicine composition for the treatment of diabetes, is made up of the crude drug of following weight: Concha Ostreae 20 grams, Radix Polygoni Multiflori 20 grams, Cortex Lycii 20 grams, Radix Rehmanniae 20 grams, the Radix Aucklandiae 20 grams, Radix Achyranthis Bidentatae 20 grams, 15 grams, Poria, Radix Paeoniae Rubra 15 grams, Rhizoma Chuanxiong 15 grams, Cortex Moutan 15 grams, Os Draconis 15 grams, Radix Ophiopogonis 15 grams, Fructus Schisandrae Chinensis 15 grams, Rhizoma Alismatis 15 grams, Fructus Corni 15 grams, Radix Codonopsis 15 grams, Semen Cuscutae 10 grams, Fructus Amomi 6 grams, 6 grams, Radix Glycyrrhizae.
Preparation and instructions of taking: with example one.
Embodiment 3: a kind of Chinese medicine composition for the treatment of diabetes, is made up of the crude drug of following weight: Concha Ostreae 20 grams, Radix Polygoni Multiflori 20 grams, Cortex Lycii 20 grams, Radix Rehmanniae 20 grams, the Radix Aucklandiae 15 grams, Radix Achyranthis Bidentatae 15 grams, 15 grams, Poria, Radix Paeoniae Rubra 15 grams, Rhizoma Chuanxiong 15 grams, Cortex Moutan 15 grams, Os Draconis 15 grams, Radix Ophiopogonis 10 grams, Fructus Schisandrae Chinensis 10 grams, Rhizoma Alismatis 10 grams, Fructus Corni 10 grams, Radix Codonopsis 10 grams, Semen Cuscutae 10 grams, Fructus Amomi 6 grams, 6 grams, Radix Glycyrrhizae.
Preparation and instructions of taking: with example one.
Embodiment 4: a kind of Chinese medicine composition for the treatment of diabetes, is made up of the crude drug of following weight: Concha Ostreae 25 grams, Radix Polygoni Multiflori 25 grams, Cortex Lycii 20 grams, Radix Rehmanniae 20 grams, the Radix Aucklandiae 20 grams, Radix Achyranthis Bidentatae 20 grams, 15 grams, Poria, Radix Paeoniae Rubra 15 grams, Rhizoma Chuanxiong 15 grams, Cortex Moutan 15 grams, Os Draconis 15 grams, Radix Ophiopogonis 10 grams, Fructus Schisandrae Chinensis 10 grams, Rhizoma Alismatis 10 grams, Fructus Corni 10 grams, Radix Codonopsis 10 grams, Semen Cuscutae 10 grams, Fructus Amomi 3 grams, 6 grams, Radix Glycyrrhizae.
Preparation and instructions of taking: with example one.
Embodiment 5: a kind of Chinese medicine composition for the treatment of diabetes, is made up of the crude drug of following weight: Concha Ostreae 20 grams, Radix Polygoni Multiflori 20 grams, Cortex Lycii 20 grams, Radix Rehmanniae 15 grams, the Radix Aucklandiae 15 grams, Radix Achyranthis Bidentatae 15 grams, 15 grams, Poria, Radix Paeoniae Rubra 15 grams, Rhizoma Chuanxiong 15 grams, Cortex Moutan 12 grams, Os Draconis 12 grams, Radix Ophiopogonis 12 grams, Fructus Schisandrae Chinensis 12 grams, Rhizoma Alismatis 10 grams, Fructus Corni 10 grams, Radix Codonopsis 10 grams, Semen Cuscutae 10 grams, Fructus Amomi 6 grams, 6 grams, Radix Glycyrrhizae.
Preparation and instructions of taking: with example one.

Claims (1)

1. treat a Chinese medicine composition for diabetes, it is characterized in that, be made up of the crude drug of following weight: Concha Ostreae 20 grams, Radix Polygoni Multiflori 20 grams, Cortex Lycii 20 grams, Radix Rehmanniae 20 grams, the Radix Aucklandiae 15 grams, Radix Achyranthis Bidentatae 15 grams, 15 grams, Poria, Radix Paeoniae Rubra 15 grams, Rhizoma Chuanxiong 15 grams, Cortex Moutan 15 grams, Os Draconis 15 grams, Radix Ophiopogonis 10 grams, Fructus Schisandrae Chinensis 10 grams, Rhizoma Alismatis 10 grams, Fructus Corni 10 grams, Radix Codonopsis 10 grams, Semen Cuscutae 10 grams, Fructus Amomi 6 grams, 6 grams, Radix Glycyrrhizae.
CN201310704612.4A 2013-12-19 2013-12-19 A kind of Chinese medicine composition for the treatment of diabetes Expired - Fee Related CN103656460B (en)

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CN104383323A (en) * 2014-11-05 2015-03-04 安徽金太阳生化药业有限公司 Traditional Chinese medicine for treating diabetes mellitus and preparation method of traditional Chinese medicine
CN104352993A (en) * 2014-11-27 2015-02-18 岑明 Traditional Chinese medicine for treating diabetes mellitus

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1238955A (en) * 1998-06-12 1999-12-22 许世平 'Xinankang' pill for heart disease
CN103405658A (en) * 2013-08-28 2013-11-27 安耀苍 Drug for treating diabetes mellitus and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1238955A (en) * 1998-06-12 1999-12-22 许世平 'Xinankang' pill for heart disease
CN103405658A (en) * 2013-08-28 2013-11-27 安耀苍 Drug for treating diabetes mellitus and preparation method thereof

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