CN104887949B - A kind of Chinese medicine preparation for the treatment of DCM (dilated cardiomyopathy) and preparation method thereof - Google Patents
A kind of Chinese medicine preparation for the treatment of DCM (dilated cardiomyopathy) and preparation method thereof Download PDFInfo
- Publication number
- CN104887949B CN104887949B CN201510364779.XA CN201510364779A CN104887949B CN 104887949 B CN104887949 B CN 104887949B CN 201510364779 A CN201510364779 A CN 201510364779A CN 104887949 B CN104887949 B CN 104887949B
- Authority
- CN
- China
- Prior art keywords
- radix
- chinese medicine
- medicine preparation
- dcm
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 77
- 206010056370 Congestive cardiomyopathy Diseases 0.000 title claims abstract description 70
- 201000010046 dilated cardiomyopathy Diseases 0.000 title claims abstract description 70
- 238000002360 preparation method Methods 0.000 title claims abstract description 54
- 239000009636 Huang Qi Substances 0.000 claims abstract description 20
- 241000222640 Polyporus Species 0.000 claims abstract description 20
- 229940079593 drugs Drugs 0.000 claims description 22
- 239000000706 filtrate Substances 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 19
- 239000008187 granular material Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 201000010874 syndrome Diseases 0.000 claims description 11
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 10
- 210000000582 Semen Anatomy 0.000 claims description 10
- 230000001476 alcoholic Effects 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 239000012567 medical material Substances 0.000 claims description 7
- 238000004064 recycling Methods 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 6
- 208000002193 Pain Diseases 0.000 abstract description 13
- 230000001737 promoting Effects 0.000 abstract description 12
- 241000668709 Dipterocarpus costatus Species 0.000 abstract description 10
- 208000004880 Polyuria Diseases 0.000 abstract description 10
- 230000035619 diuresis Effects 0.000 abstract description 10
- 230000025627 positive regulation of urine volume Effects 0.000 abstract description 10
- 230000001717 pathogenic Effects 0.000 abstract description 7
- 239000002994 raw material Substances 0.000 abstract description 7
- 210000004369 Blood Anatomy 0.000 abstract description 6
- 239000008280 blood Substances 0.000 abstract description 6
- 244000052769 pathogens Species 0.000 abstract description 6
- 230000017531 blood circulation Effects 0.000 abstract description 4
- 230000000414 obstructive Effects 0.000 abstract description 3
- 230000001225 therapeutic Effects 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 description 14
- 230000000694 effects Effects 0.000 description 12
- 206010030113 Oedema Diseases 0.000 description 10
- 230000004217 heart function Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 210000004072 Lung Anatomy 0.000 description 8
- 210000000952 Spleen Anatomy 0.000 description 8
- 206010012735 Diarrhoea Diseases 0.000 description 7
- 210000003734 Kidney Anatomy 0.000 description 7
- 230000000240 adjuvant Effects 0.000 description 7
- 239000002671 adjuvant Substances 0.000 description 7
- 235000009508 confectionery Nutrition 0.000 description 7
- 230000003203 everyday Effects 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- 210000004185 Liver Anatomy 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 208000005846 Cardiomyopathy Diseases 0.000 description 4
- 206010008479 Chest pain Diseases 0.000 description 4
- 201000008031 cardiomyopathy Diseases 0.000 description 4
- 210000000038 chest Anatomy 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 206010007554 Cardiac failure Diseases 0.000 description 3
- 210000003414 Extremities Anatomy 0.000 description 3
- 206010019280 Heart failure Diseases 0.000 description 3
- 210000003141 Lower Extremity Anatomy 0.000 description 3
- 206010030302 Oliguria Diseases 0.000 description 3
- 230000001914 calming Effects 0.000 description 3
- 201000008286 diarrhea Diseases 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 231100000486 side effect Toxicity 0.000 description 3
- 210000001015 Abdomen Anatomy 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 2
- 208000006673 Asthma Diseases 0.000 description 2
- 206010063659 Aversion Diseases 0.000 description 2
- 208000006029 Cardiomegaly Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010011703 Cyanosis Diseases 0.000 description 2
- 208000002173 Dizziness Diseases 0.000 description 2
- 206010013990 Dysuria Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010022437 Insomnia Diseases 0.000 description 2
- 210000000088 Lip Anatomy 0.000 description 2
- 210000000214 Mouth Anatomy 0.000 description 2
- 210000004165 Myocardium Anatomy 0.000 description 2
- 206010028640 Myopathy Diseases 0.000 description 2
- 206010030124 Oedema peripheral Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 229940023488 Pill Drugs 0.000 description 2
- 206010038748 Restrictive cardiomyopathy Diseases 0.000 description 2
- 210000003932 Urinary Bladder Anatomy 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 239000007938 effervescent tablet Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000019525 fullness Nutrition 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 201000010770 muscular disease Diseases 0.000 description 2
- 201000009623 myopathy Diseases 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000001105 regulatory Effects 0.000 description 2
- 239000009877 shengmai Substances 0.000 description 2
- 230000002269 spontaneous Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 238000002562 urinalysis Methods 0.000 description 2
- 230000002861 ventricular Effects 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010002383 Angina pectoris Diseases 0.000 description 1
- 206010003119 Arrhythmia Diseases 0.000 description 1
- 208000002894 Beriberi Diseases 0.000 description 1
- 210000001124 Body Fluids Anatomy 0.000 description 1
- 229940046011 Buccal Tablet Drugs 0.000 description 1
- FAKRSMQSSFJEIM-RQJHMYQMSA-N Captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 description 1
- 206010007521 Cardiac arrhythmias Diseases 0.000 description 1
- 229940068682 Chewable Tablet Drugs 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000000325 Deficiency Disease Diseases 0.000 description 1
- 206010012601 Diabetes mellitus Diseases 0.000 description 1
- LTMHDMANZUZIPE-PUGKRICDSA-N Digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 1
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 1
- 206010013023 Diphtheria Diseases 0.000 description 1
- 208000001848 Dysentery Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013974 Dyspnoea paroxysmal nocturnal Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000005679 Eczema Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 206010019233 Headache Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 206010019705 Hepatic pain Diseases 0.000 description 1
- 210000001624 Hip Anatomy 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010020871 Hypertrophic cardiomyopathy Diseases 0.000 description 1
- 210000000936 Intestines Anatomy 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 208000007903 Liver Failure Diseases 0.000 description 1
- 206010027327 Menstrual disease Diseases 0.000 description 1
- 206010029410 Night sweats Diseases 0.000 description 1
- 206010031123 Orthopnoea Diseases 0.000 description 1
- 206010034568 Peripheral coldness Diseases 0.000 description 1
- 231100000614 Poison Toxicity 0.000 description 1
- 208000008425 Protein Deficiency Diseases 0.000 description 1
- 206010061920 Psychotic disease Diseases 0.000 description 1
- 210000004915 Pus Anatomy 0.000 description 1
- 206010038435 Renal failure Diseases 0.000 description 1
- 206010062104 Renal mass Diseases 0.000 description 1
- 206010072736 Rheumatic disease Diseases 0.000 description 1
- 210000002784 Stomach Anatomy 0.000 description 1
- 231100000765 Toxin Toxicity 0.000 description 1
- 206010052769 Vertigos Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 201000005794 allergic hypersensitivity disease Diseases 0.000 description 1
- 201000000736 amenorrhea Diseases 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000006189 buccal tablet Substances 0.000 description 1
- 229960000830 captopril Drugs 0.000 description 1
- 230000002612 cardiopulmonary Effects 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 230000001684 chronic Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 201000004624 dermatitis Diseases 0.000 description 1
- 229960005156 digoxin Drugs 0.000 description 1
- 239000007919 dispersible tablet Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 231100001003 eczema Toxicity 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000032686 female pregnancy Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 201000010238 heart disease Diseases 0.000 description 1
- 230000002607 hemopoietic Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000002045 lasting Effects 0.000 description 1
- 230000003902 lesions Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 230000002175 menstrual Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 230000003000 nontoxic Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N p-acetaminophenol Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 201000001474 proteinuria Diseases 0.000 description 1
- 230000001047 pyretic Effects 0.000 description 1
- 230000000552 rheumatic Effects 0.000 description 1
- 231100000247 serious adverse effect Toxicity 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
Abstract
The invention belongs to medical art, be specifically related to a kind of Chinese medicine preparation for the treatment of DCM (dilated cardiomyopathy) and preparation method thereof, described Chinese medicine preparation is made up of following raw material medicaments: the Radix Astragali, Polyporus, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, the Radix Paeoniae Alba, Poria, Semen Plantaginis, Radix Stephaniae Tetrandrae, Radix Ophiopogonis, Chinese medicine preparation of the present invention for primary efficacy, has significant therapeutic effect to gas sun deficiency DCM (dilated cardiomyopathy) with benefiting qi and raising yang, dispersing cold for relieving pain, promoting diuresis to eliminate damp pathogen, nourishing YIN and benefiting blood, promoting blood circulation to remove obstruction in the collateral.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine preparation for the treatment of DCM (dilated cardiomyopathy) and preparation method thereof.
Background technology
Cardiomyopathy is that a kind of cause of disease is complicated, and basic lesion betides cardiac muscle and causes cardiac muscle can not the heart disease of normal contraction.With cardiac dilatation, out of breath after tired, orthopnea or paroxysmal nocturnal dyspnea, edema of lower limbs, cardiopalmus, uncomfortable in chest, angina pectoris etc. are clinical principal character.Primary disease is divided into primary cardiac myopathy and secondary cardiomyopathy two type by the cause of disease, and be divided into dilated cardiomyopathy, hypertrophic cardiomyopathy and restrictive cardiomyopathy three types by pathology, wherein DCM (dilated cardiomyopathy) is comparatively common, and restrictive cardiomyopathy is domestic rare.Cardiomyopathy onset is slow, but course of disease speed differs.All cardiac dilatation are obvious, and heart failure is lasting, or arrhythmia bigot, and prognosis is not good.The category such as " cardiopalmus ", " thoracic obstruction ", " the syndrome of dyspnea ", " edema " is belonged in theory of Chinese medical science center myopathy.Medicine typing is the weak disease of the motive, gentle positive two deficient syndromes of deficiency of both QI and YIN disease, and by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, the treatment of reasonable formula to DCM (dilated cardiomyopathy) has the incomparable advantage of doctor trained in Western medicine, and toxic and side effects is little.Thus the more significant Chinese medicine preparation of discuss and study treatment DCM (dilated cardiomyopathy) curative effect has larger meaning.
Summary of the invention
The invention provides a kind of new Chinese medicine preparation for the treatment of DCM (dilated cardiomyopathy), this Chinese medicine preparation is rapid-action, good effect, toxic and side effects is little, and it only will be obtained by following 9 taste raw materials: the Radix Astragali, Polyporus, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, the Radix Paeoniae Alba, Poria, Semen Plantaginis, Radix Stephaniae Tetrandrae, Radix Ophiopogonis.
The technical scheme adopted for solving its technical problem is the Chinese medicine preparation of described treatment DCM (dilated cardiomyopathy), is made up of the medicine material of following weight: Radix Astragali 15-20g, Polyporus 10-15g, Cortex Cinnamomi 3-8g, Radix Aconiti Lateralis Preparata 8-12g, Radix Paeoniae Alba 5-10g, Poria 5-10g, Semen Plantaginis 10-15g, Radix Stephaniae Tetrandrae 5-10g, Radix Ophiopogonis 15-20g.
The preferred technical solution of the present invention is that described Chinese medicine preparation of the present invention is obtained by the crude drug of following weight portion: Radix Astragali 18g, Polyporus 12g, Cortex Cinnamomi 5g, Radix Aconiti Lateralis Preparata 10g, Radix Paeoniae Alba 7g, Poria 8g, Semen Plantaginis 12g, Radix Stephaniae Tetrandrae 8g, Radix Ophiopogonis 18g.
Present invention also offers the preparation method of described Chinese medicine preparation, specifically comprise the steps: the crude drug Radix Astragali of above-mentioned weight portion, Polyporus, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, the Radix Paeoniae Alba, Poria, Semen Plantaginis, Radix Stephaniae Tetrandrae, Radix Ophiopogonis pulverized 80-120 mesh sieve respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 5-8 times amount, each 2 hours, filter cleaner extracting juice merges, and the filtrate after merging is concentrated, the alcoholic solution that volumetric concentration is 60% ~ 80% is doubly added again according to the 3-5 of filtrate gross weight, reflux, extract, three times, return time is 2-3h, filter, filtrate recycling ethanol, cold filtration, wash with water, namely Chinese medical concrete is obtained after drying.
Those skilled in the art directly can be used as medicine on obtained active constituents of medicine basis of the present invention to use or add on pharmaceutics acceptable adjuvant routinely technique be prepared into required preparation.As the oral drugs of the solid dosage form such as conventional tablet (dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, effervescent tablet), capsule (hard capsule, soft capsule), granule, pill (drop pill), powder can be made, the oral drugs of the liquid forms such as syrup, oral liquid, water preparation, mixture, decoction also can be made.Therefore, in this Chinese medicine preparation except effective ingredient, pharmaceutically acceptable adjuvant can also be contained.Preferably, Chinese medicine preparation of the present invention conveniently preparation technology be prepared into granule, tablet, capsule, electuary or powder etc.Most preferably, Chinese medicine preparation of the present invention conveniently preparation technology be prepared into granule.
The present invention also asks to protect above-mentioned Chinese medicine preparation in the purposes of preparation treatment DCM (dilated cardiomyopathy) particularly in preparation treatment gas sun deficiency DCM (dilated cardiomyopathy) medicine.Known by clinical trial, after treating 1 course for the treatment of, treatment group and the clinical obvious effective rate of matched group symptom curative effect are respectively 66.7%, 40.0%, and treatment group and matched group symptom curative effect total effective rate are respectively 95.6%, 73.3%.Treatment group symptom obvious effective rate, total effective rate are obviously better than matched group as can be seen from Table 1, through statistical procedures there were significant differences P < 0.05.LVED (Left Ventricular End Systolic Dimension) (LVEDD) and ejection fraction (EF) situation of change as can be seen from Table 2.Before and after two groups of treatments, LVEFD and EF self more all have clear improvement (P < 0.05, P < 0.01), between group, comparison therapy group is all better than matched group (P < 0.05, P < 0.01), and treatment group LVEFD and EF improvement is better than matched group.In safety evaluatio, the routine blood test before and after treatment group patient consumes, routine urinalysis etc. inspections do not find obvious exception.Illustrate that using Chinese medicine preparation of the present invention treatment DCM (dilated cardiomyopathy) particularly to treat belongs to gas sun two deficiency syndrome DCM (dilated cardiomyopathy) determined curative effects thus, serve the remarkable result for the treatment of both the principal and secondary aspects of a disease, safe and reliable, can be used as the effective ways for the treatment of gas sun two deficiency syndrome DCM (dilated cardiomyopathy) diseases, be worth of widely use in clinical.
In Chinese medicine preparation of the present invention, functional effect and the side of each Chinese medicine component separate as follows:
The Radix Astragali, warm in nature, sweet in the mouth.Invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting., chronic diarrhea proctoptosis, spontaneous perspiration, edema weak for the deficiency of vital energy, sub-official prolapsus, chronic nephritis proteinuria, diabetes, open sore part disunion of a specified duration.。
Polyporus, sweet, light, flat.Return kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen.For dysuria, edema, has loose bowels, stranguria with turbid discharge, leukorrhagia.
Cortex Cinnamomi, pungent, sweet, hot greatly.Return kidney, spleen, the heart, Liver Channel.Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Radix Aconiti Lateralis Preparata, pungent, sweet, hot greatly; Poisonous.GUIXIN, kidney, spleen channel.Recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, by wind-cold damp pathogen.For YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.
The Radix Paeoniae Alba, bitter, sour, be slightly cold.Return liver, spleen channel.Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Poria is sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Semen Plantaginis, sweet, be slightly cold.Return liver, kidney, lung, small intestine meridian.Clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminates the phlegm.For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.
Radix Stephaniae Tetrandrae is bitter, cold.Return bladder, lung meridian.Inducing diuresis to remove edema, wind-expelling pain-stopping.For edema beriberi, dysuria, eczema sore, rheumatic arthralgia; Hypertension.
Radix Ophiopogonis, sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.
QI-deficiency of the heart and lung, hypofunction of YANG QI in chest, painstaking effort lose fortune, blockage of the cardiac vessels, therefore see chest distress, or chest pain, dark complexion, cyanotic lips; Deficiency of heart-YANG and kidney-YANG, disturbance in functioning of QI, fluid-retention stagnating in the interior, upper icepro cardiopulmonary thought-read is throbbed with fear asthma, can not put down sleeping, night weakened YANG QI, therefore asthma aggravation; Hinder in diseases caused by retention of fluid, insufficiency of the spleen mistake be good for, then distension and fullness of the chest and abdomen, Na Gu not under; Diseases caused by retention of fluid dysentery, then oliguria, lower limb foot edema; Yang-energy is on the decline, loses in warm survey aversion to cold and cold limbs; Light red tongue is fat and purple, white, slippery and moist fur, deep-thready pulse knot generation, is gas sun two empty, and what blood stasis drink stopped levies.The present invention is from the cogitive theory of the traditional Chinese medical science to gas sun deficiency DCM (dilated cardiomyopathy), for the purpose of benefiting qi and raising yang, dispersing cold for relieving pain, promoting diuresis to eliminate damp pathogen, nourishing YIN and benefiting blood, promoting blood circulation to remove obstruction in the collateral, carry out scientific composition, its various crude drug mild in medicine property selected and, nontoxic, safe and reliable, prepare easy, cost is low, and curative effect is fast, the Radix Astragali, Radix Stephaniae Tetrandrae in side, benefiting QI for strengthening the superficies, menstruction regulating and pain relieving, inducing diuresis to remove edema, wind-expelling pain-stopping; Polyporus, Poria, Semen Plantaginis, promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, YANG invigorating is dispeled cold, promoting blood circulation and stopping pain; The Radix Paeoniae Alba, Radix Ophiopogonis, suppressing the hyperactive liver lung moistening, nourishing YIN and benefiting blood, mind calming pain relieving.All medicines are harmonious, and effectively can treat DCM (dilated cardiomyopathy) particularly gas sun two deficiency syndrome DCM (dilated cardiomyopathy).Verify through clinical practice, take Chinese medicine preparation of the present invention treatment gas sun two deficiency syndrome DCM (dilated cardiomyopathy), determined curative effect, mild in medicine property and, side effect is low, and safety coefficient is high, clinical observation cure rate, total effective rate are high, LVEFD and EF all has clear improvement, and dosage form medication prepared by the present invention is simultaneously convenient, improves the compliance of dilated cardiomyopathy patients.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 granule/electuary
Take each raw material of the present invention by following weight portion: Radix Astragali 18g, Polyporus 12g, Cortex Cinnamomi 5g, Radix Aconiti Lateralis Preparata 10g, Radix Paeoniae Alba 7g, Poria 8g, Semen Plantaginis 12g, Radix Stephaniae Tetrandrae 8g, Radix Ophiopogonis 18g.
Preparation technology is as follows: the Radix Astragali of above-mentioned weight portion, Polyporus, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, the Radix Paeoniae Alba, Poria, Semen Plantaginis, Radix Stephaniae Tetrandrae, Radix Ophiopogonis were pulverized 80-120 mesh sieve respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 7 times amount, each 2 hours, filter cleaner extracting juice merges, and the filtrate after merging is concentrated, the alcoholic solution that volumetric concentration is 70% is added again according to 4 times of filtrate gross weight, reflux, extract, three times, return time is 3h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying.Those skilled in the art directly can be used as medicine on this basis to use or add adjuvant conventional formulation technique and be obtained granule.
When using Chinese medicine preparation of the present invention to treat DCM (dilated cardiomyopathy) card, when taking prepared granule, every bag contains crude drug amount 1g, every day 3 times, each 1 bag.
Embodiment 2 tablet
Take each raw material of the present invention by following weight portion: Radix Astragali 18g, Polyporus 12g, Cortex Cinnamomi 5g, Radix Aconiti Lateralis Preparata 10g, Radix Paeoniae Alba 7g, Poria 8g, Semen Plantaginis 12g, Radix Stephaniae Tetrandrae 8g, Radix Ophiopogonis 18g.
Preparation technology is as follows: the crude drug Radix Astragali of above-mentioned weight portion, Polyporus, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, the Radix Paeoniae Alba, Poria, Semen Plantaginis, Radix Stephaniae Tetrandrae, Radix Ophiopogonis were pulverized 80-120 mesh sieve respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 7 times amount, each 2 hours, filter cleaner extracting juice merges, and the filtrate after merging is concentrated, the alcoholic solution that volumetric concentration is 70% is added again according to 4 times of filtrate gross weight, reflux, extract, three times, return time is 2h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying.Those skilled in the art directly can be used as medicine on this basis to use or add adjuvant conventional formulation technique and be obtained tablet.
When using Chinese medicine preparation of the present invention to treat DCM (dilated cardiomyopathy) card, when taking prepared tablet, every sheet contains crude drug amount 0.15g, every day 3 times, each 4.
Embodiment 3 capsule
Take each raw material of the present invention by following weight portion: Radix Astragali 18g, Polyporus 12g, Cortex Cinnamomi 5g, Radix Aconiti Lateralis Preparata 10g, Radix Paeoniae Alba 7g, Poria 8g, Semen Plantaginis 12g, Radix Stephaniae Tetrandrae 8g, Radix Ophiopogonis 18g.
Preparation technology is as follows: the crude drug Radix Astragali of above-mentioned weight portion, Polyporus, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, the Radix Paeoniae Alba, Poria, Semen Plantaginis, Radix Stephaniae Tetrandrae, Radix Ophiopogonis were pulverized 80-120 mesh sieve respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 7 times amount, each 2 hours, filter cleaner extracting juice merges, and the filtrate after merging is concentrated, the alcoholic solution that volumetric concentration is 70% is added again according to 4 times of filtrate gross weight, reflux, extract, three times, return time is 2h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying.Those skilled in the art directly can be used as medicine on this basis to use or add adjuvant conventional formulation technique and be obtained capsule.
When using Chinese medicine preparation of the present invention to treat DCM (dilated cardiomyopathy) card, when taking prepared capsule, every contains crude drug amount 0.15g, every day 3 times, each 4.
Embodiment 4 granule
Take each raw material of the present invention by following weight portion: Radix Astragali 15g, Polyporus 10g, Cortex Cinnamomi 3g, Radix Aconiti Lateralis Preparata 8g, Radix Paeoniae Alba 5g, Poria 5g, Semen Plantaginis 10g, Radix Stephaniae Tetrandrae 5g, Radix Ophiopogonis 15g.
Preparation technology is as follows: the crude drug Radix Astragali of above-mentioned weight portion, Polyporus, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, the Radix Paeoniae Alba, Poria, Semen Plantaginis, Radix Stephaniae Tetrandrae, Radix Ophiopogonis were pulverized 80-120 mesh sieve respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 5 times amount, each 2 hours, filter cleaner extracting juice merges, and the filtrate after merging is concentrated, the alcoholic solution that volumetric concentration is 60% is added again according to 3 times of filtrate gross weight, reflux, extract, three times, return time is 2h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying.Those skilled in the art directly can be used as medicine on this basis to use or add adjuvant conventional formulation technique and be obtained granule.
When using Chinese medicine preparation of the present invention to treat DCM (dilated cardiomyopathy) card, when taking prepared granule, every bag contains crude drug amount 1g, every day 3 times, each 1 bag.
Embodiment 5 granule
Take each raw material of the present invention by following weight portion: Radix Astragali 20g, Polyporus 15g, Cortex Cinnamomi 8g, Radix Aconiti Lateralis Preparata 12g, Radix Paeoniae Alba 10g, Poria 10g, Semen Plantaginis 15g, Radix Stephaniae Tetrandrae 10g, Radix Ophiopogonis 20g.
Preparation technology is as follows: the crude drug Radix Astragali of above-mentioned weight portion, Polyporus, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, the Radix Paeoniae Alba, Poria, Semen Plantaginis, Radix Stephaniae Tetrandrae, Radix Ophiopogonis were pulverized 80-120 mesh sieve respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 8 times amount, each 2 hours, filter cleaner extracting juice merges, and the filtrate after merging is concentrated, the alcoholic solution that volumetric concentration is 80% is added again according to 5 times of filtrate gross weight, reflux, extract, three times, return time is 3h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying.Those skilled in the art directly can be used as medicine on this basis to use or add adjuvant conventional formulation technique and be obtained granule.
When using Chinese medicine preparation of the present invention to treat DCM (dilated cardiomyopathy) card, when taking prepared granule, every bag contains crude drug amount 1g, every day 3 times, each 1 bag.
The clinical observation of embodiment 6 Chinese medicine preparation treatment of the present invention DCM (dilated cardiomyopathy)
1, case-data:
Outpatient service and ward are diagnosed as patient 90 example of gas sun deficiency DCM (dilated cardiomyopathy), are divided into treatment group, matched group at random.Wherein treatment group 45 example, man 26 example, female 19 example; The oldest person 60 years old, reckling 19 years old, 35.9 ± 3.52 years old mean age, its center function is II grade of patient 10 example, and cardiac function is III grade of patient 26 example, and cardiac function is IV grade of patient 9 example.Matched group 45 example, man 25 example, female 20 example; The oldest person 58 years old, reckling 18 years old, 36.2 ± 3.68 years old mean age, its center function is II grade of patient 11 example, and cardiac function is III grade of patient 25 example, and cardiac function is IV grade of patient 9 example.Two groups of patients there was no significant difference (P > 0.05) in sex, age, the course of disease, the state of an illness etc., has comparability.
2, diagnosis basis
All meet nineteen ninety-five WHO/ISFC diagnostic criteria.
Syndrome Differentiation of Traditional Chinese Medicine is gas sun two deficient syndrome shapes: chest distress, or have chest pain, and cardiopalmus is panted, and can not put down sleeping, and night aggravates, distension and fullness of the chest and abdomen, Na Gu not under, oliguria, lower limb foot edema, aversion to cold and cold limbs, dark complexion, cyanotic lips.Light red tongue is fat and purple, white, slippery and moist fur, deep-thready pulse knot generation.This type sees the cardiomyopathy heart failure serious phase.
3, inclusive criteria:
(1) diagnosis basis is met;
(2) meet Chinese medical discrimination diagnostic criteria and belong to gas sun deficiency DCM (dilated cardiomyopathy) person;
(3) age 18-60 year, male or female;
(4) clinical research " Informed Consent Form " is signed.
4, Excluded cases standard:
(1) due to heart failure person that liver and kidney failure causes;
(2) gestation or women breast-feeding their children;
(3) Liver and kidney and the severe primary such as endocrine, hemopoietic system disease and psychotic patient is merged;
(4) to the known composition allergy sufferers of this medicine.
5, to reject and the standard that comes off:
(1), after case is selected in, find not meet inclusive criteria or meet exclusion standard person;
(2) there is serious adverse events, judge to stop this case clinical trial person according to doctor;
(3) case selected after data not entirely or not by specifying medication person;
(4) in process of the test, experimenter's compliance is poor, and affect the treatment estimator.
6, usage and dosage:
Matched group: give SHENGMAI ZHUSHEYE 40mL+5% Glucose Liquid 250mL, quiet, 15 ~ 30/min, continuous 14 days, rear continuation used each 2 of SHENGMAI JIAONANG, oral, 3 times on the 1st, digoxin 0.125g, captopril 0.125g are oral, 2 times on the 1st, 2 months courses for the treatment of.。
Treatment group: give Drug therapy of the present invention, granule prepared by Example 1, containing crude drug amount 1g, every day 3 times, each 1 bag, takes for every bag after the meal half an hour.
Two groups of patients, at treatments period, except above-mentioned treatment, must not use other therapies.February is 1 course for the treatment of, after treating 1 course for the treatment of, and statistical observation record.
7, criterion of therapeutical effect: effective in cure judging quota all meet curative effect determinate standard in " new Chinese medicine guideline of clinical investigations ".
Effective: all symptoms, sign and decentraction function are all significantly improved, and cardiac function is improved to more than II grade;
Effective: symptom, sign and cardiac function all make moderate progress, cardiac function is improved to more than I level;
Invalid: the various clinical symptoms of patient all do not obtain any improvement, the phenomenon increased the weight of even in addition.
Total effective rate=obvious effective rate+effective percentage.
8, therapeutic outcome:
In therapeutic process, nothing exits, come off case, all completes clinical observation.
After treating 1 course for the treatment of, treatment group and the clinical obvious effective rate of matched group symptom curative effect are respectively 66.7%, 40.0%, and treatment group and matched group symptom curative effect total effective rate are respectively 95.6%, 73.3%.Treatment group symptom obvious effective rate, total effective rate are obviously better than matched group as can be seen from Table 1, have pole significant difference P < 0.05 through statistical procedures.LVED (Left Ventricular End Systolic Dimension) (LVEDD) and ejection fraction (EF) situation of change as can be seen from Table 2.Before and after two groups of treatments, LVEFD and EF self more all have clear improvement (P < 0.05, P < 0.01), between group, comparison therapy group is all better than matched group (P < 0.05, P < 0.01), and treatment group LVEFD and EF improvement is better than matched group.
Table 1. liang group symptom comparitive study
| Group | n | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 45 | 30 | 13 | 2 | 43(95.6％) |
| Matched group | 45 | 18 | 15 | 12 | 33(73.3％) |
Before and after table 2. liang group treatment, cardiac function compares
Note: compare with before treatment
☆p < 0.05,
☆ ☆p < 0.01; Compare with matched group
△p < 0.05,
△ △p < 0.01.
From clinical observation result, treatment group symptom obvious effective rate, total effective rate, cardiac function improve situation and are all obviously better than matched group, and this Chinese medicine preparation improves obviously DCM (dilated cardiomyopathy) clinical symptoms as seen.Simultaneously in safety evaluatio, the routine blood test before and after treatment group patient consumes, routine urinalysis etc. inspections do not find obvious exception.Illustrate that using Chinese medicine preparation of the present invention treatment DCM (dilated cardiomyopathy) particularly to treat belongs to gas sun two deficiency syndrome DCM (dilated cardiomyopathy) determined curative effects thus, safe and reliable, can be used as the effective ways for the treatment of gas sun two deficiency syndrome DCM (dilated cardiomyopathy), be worth of widely use in clinical.
Claims (8)
1. treat the Chinese medicine preparation of DCM (dilated cardiomyopathy) for one kind, it is characterized in that, it is obtained by the crude drug of following weight portion: Radix Astragali 15-20g, Polyporus 10-15g, Cortex Cinnamomi 3-8g, Radix Aconiti Lateralis Preparata 8-12g, Radix Paeoniae Alba 5-10g, Poria 5-10g, Semen Plantaginis 10-15g, Radix Stephaniae Tetrandrae 5-10g, Radix Ophiopogonis 15-20g.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, it is obtained by the crude drug of following weight portion: Radix Astragali 18g, Polyporus 12g, Cortex Cinnamomi 5g, Radix Aconiti Lateralis Preparata 10g, Radix Paeoniae Alba 7g, Poria 8g, Semen Plantaginis 12g, Radix Stephaniae Tetrandrae 8g, Radix Ophiopogonis 18g.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, described Chinese medicine preparation is oral formulations.
4. Chinese medicine preparation as claimed in claim 3, it is characterized in that, described oral formulations is tablet, electuary, capsule or granule.
5. Chinese medicine preparation as claimed in claim 4, it is characterized in that, described oral formulations is granule.
6. prepare the method for Chinese medicine preparation as claimed in claim 1 or 2 for one kind, it is characterized in that, comprise the steps: the crude drug Radix Astragali of above-mentioned weight portion, Polyporus, Cortex Cinnamomi, Radix Aconiti Lateralis Preparata, the Radix Paeoniae Alba, Poria, Semen Plantaginis, Radix Stephaniae Tetrandrae, Radix Ophiopogonis pulverized 80-120 mesh sieve respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 5-8 times amount, each 2 hours, filter cleaner extracting juice merges, and the filtrate after merging is concentrated, the alcoholic solution that volumetric concentration is 60% ~ 80% is doubly added again according to the 3-5 of filtrate gross weight, reflux, extract, three times, return time is 2-3h, filter, filtrate recycling ethanol, cold filtration, wash with water, namely Chinese medical concrete is obtained after drying.
7. the purposes of Chinese medicine preparation as claimed in claim 1 or 2 in preparation treatment DCM (dilated cardiomyopathy) medicine.
8. the purposes of Chinese medicine preparation as claimed in claim 1 or 2 in preparation treatment gas sun two deficiency syndrome DCM (dilated cardiomyopathy) medicines.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510364779.XA CN104887949B (en) | 2015-06-29 | 2015-06-29 | A kind of Chinese medicine preparation for the treatment of DCM (dilated cardiomyopathy) and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510364779.XA CN104887949B (en) | 2015-06-29 | 2015-06-29 | A kind of Chinese medicine preparation for the treatment of DCM (dilated cardiomyopathy) and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104887949A CN104887949A (en) | 2015-09-09 |
| CN104887949B true CN104887949B (en) | 2016-02-24 |
Family
ID=54021191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510364779.XA Active CN104887949B (en) | 2015-06-29 | 2015-06-29 | A kind of Chinese medicine preparation for the treatment of DCM (dilated cardiomyopathy) and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104887949B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101322801A (en) * | 2007-06-15 | 2008-12-17 | 河北以岭医药研究院有限公司 | Use of Chinese medicinal composition in preparing medicament for treating dilated cardiomyopathy |
-
2015
- 2015-06-29 CN CN201510364779.XA patent/CN104887949B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101322801A (en) * | 2007-06-15 | 2008-12-17 | 河北以岭医药研究院有限公司 | Use of Chinese medicinal composition in preparing medicament for treating dilated cardiomyopathy |
Non-Patent Citations (2)
| Title |
|---|
| 扩张型心肌病中医药治疗进展;李敏，等;《湖北中医杂志》;20120229;第34卷(第2期);77－78页 * |
| 扩张型心肌病的中医药治疗;曾垂义，等;《中华中医药杂志》;20121031;第27卷(第10期);2590－2592页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104887949A (en) | 2015-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102579794B (en) | Chinese herbal preparation, tablet, oral liquid and decoction for treating chronic heart failure and preparation method thereof | |
| CN103585478A (en) | Chinese medicinal composition for treating hypertension | |
| CN104815192A (en) | Pharmaceutical composition for treating hypertension and application of pharmaceutical composition | |
| CN104383257A (en) | Chinese medicinal preparation for treating xerophthalmia due to liver depression and deficiency of yin | |
| CN103920102A (en) | Traditional Chinese medicine for treating primary hypotension | |
| CN104887949B (en) | A kind of Chinese medicine preparation for the treatment of DCM (dilated cardiomyopathy) and preparation method thereof | |
| CN102406893A (en) | Chinese patent medicine for treating psoriasis. | |
| CN104800553A (en) | Traditional Chinese medicine composition for treating climacteric insomnia and preparation method of traditional Chinese medicine composition | |
| CN104622995A (en) | Pharmaceutical composition for treating chronic superficial gastritis and preparation method of pharmaceutical composition | |
| CN104840864B (en) | A kind of Chinese medicine preparation for the treatment of infantile spleen deficiency type diarrhoea | |
| CN104491316B (en) | A kind of Chinese medicine preparation for the treatment of deficiency of QI in middle-JIAO type hyperplasia of prostate | |
| CN103330861B (en) | Medicine for curing cholera and preparation method thereof | |
| CN105597004A (en) | Traditional Chinese medicine combination for treating cancer | |
| CN105726754A (en) | Folium artemisiae argyi containing traditional Chinese medicine composition for treating hemorrhagic shock and preparation method thereof | |
| CN104906298A (en) | Traditional Chinese medicine preparation for treating simple obesity and preparation method of traditional Chinese medicine preparation | |
| CN104800568A (en) | Traditional Chinese medicinal capsules used for alleviating postpartum constipation | |
| CN105343629B (en) | A kind of Chinese medicine composition and preparation method thereof for treating cardiac insufficiency | |
| CN104689154A (en) | Nursing medicine for treating postpartum fever | |
| CN104547610A (en) | Medicine composition for treating community acquired pneumonia | |
| CN104606427A (en) | Schefflera arboricola-contained traditional Chinese medicinal composition | |
| CN104587122A (en) | Traditional Chinese medicine composition for treating chronic gastritis | |
| CN104587246B (en) | A kind of Chinese medicine preparation for treating epigastric pain and preparation method thereof | |
| CN104042908A (en) | Traditional Chinese medicine composition for treating female climacteric syndrome | |
| CN103479821B (en) | Chinese medicine composition of a kind of the kidney invigorating benefit blood and preparation method thereof | |
| CN103599397A (en) | Traditional Chinese medicine composition for treating chronic renal insufficiency |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Wang Zhengliang Inventor after: Li Xiao Inventor after: Wu Dong Inventor before: The inventor has waived the right to be mentioned |
|
| COR | Change of bibliographic data | ||
| GR01 | Patent grant | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160127 Address after: Waanje Road Development Zone in Zibo City, Shandong province 255086 No. 121 (Hospital Building 1 Room 204) Applicant after: ZIBO KUAKE PHARMACEUTICAL TECHNOLOGY CO., LTD. Address before: 1 residential building, No. 443 Changjiang East Road, Huangdao District, Shandong, China, 1708, China, 266520 Applicant before: Chen Da bio tech ltd, Qingdao |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20170713 Address after: 226500 Jiangsu city of Nantong province Rugao City Ding Yan Zhen Gao Village 42 groups Patentee after: Rugao Fu friend hospital Address before: Waanje Road Development Zone in Zibo City, Shandong province 255086 No. 121 (Hospital Building 1 Room 204) Patentee before: ZIBO KUAKE PHARMACEUTICAL TECHNOLOGY CO., LTD. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20191129 Address after: 221300, Jiangsu City, Xuzhou province Pizhou Town Industrial Park Patentee after: Jiangsu love Biotechnology Co., Ltd. Address before: 226500 42 groups of Gao Nan village, Dingyan Town, Rugao City, Nantong, Jiangsu Patentee before: Rugao Fu friend hospital |
|
| TR01 | Transfer of patent right |