CN105434766A - Medicinal preparation for treating hypomenorrhea caused by pelvic inflammation - Google Patents

Medicinal preparation for treating hypomenorrhea caused by pelvic inflammation Download PDF

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CN105434766A
CN105434766A CN201610004550.XA CN201610004550A CN105434766A CN 105434766 A CN105434766 A CN 105434766A CN 201610004550 A CN201610004550 A CN 201610004550A CN 105434766 A CN105434766 A CN 105434766A
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caulis
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段希福
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention belongs to the field of traditional Chinese medicine, and discloses a medicinal preparation for treating hypomenorrhea caused by pelvic inflammation. The medicinal preparation is prepared from the following medicinal raw materials in parts by weight: 10 to 20 parts of clematis chrysocoma, 15 to 35 parts of herba euonymi, 10 to 18 parts of radix acanthopanacis semticosi, 5 to 15 parts of radix dipsaci, 15 to 30 parts of semen cuscutae, 8 to 28 parts of embelia parviflora, 10 to 30 parts of Michel's cyperus, 10 to 20 parts of codonopsis pilosula, 5 to 15 parts of pericarpium citri reticulatae and 1 to 10 parts of liquorice. According to the medicinal preparation for treating hypomenorrhea caused by pelvic inflammation, disclosed by the invention, all the medicines are in mutual action, can be used with each other, can take surprising effects, play roles in dispelling wind and eliminating dampness, invigorating the blood circulation and dispersing blood stasis, warming and nourishing qi and blood as well as stimulating the menstrual flow and activating collaterals together, and has a unique effect on hypomenorrhea caused by pelvic inflammation. Clinical observation shows that the apparent rate and the effective rate are high after the medicinal preparation is used for treating by an observation group and are remarkably higher than those of a comparison group; meanwhile, the safety is high, and the side effects are small.

Description

A kind of pharmaceutical preparation for the treatment of the hypomenorrhea caused by pelvic inflammatory disease
Technical field
The invention belongs to the field of Chinese medicines, relate to the medicine for the treatment of menoxenia, particularly relate to the pharmaceutical preparation of the hypomenorrhea that a kind for the treatment of is caused by pelvic inflammatory disease.
Background technology
Menstrual cycle is normal, and menstrual blood volume obviously reduces, or the deficiency of time 2 days of passing through, even drop and clean person, is called " hypomenorrhea ".Ancient books has title " a small amount of menses and menstruating unsmoothly ", " few through water ", " very few through measuring ".It is generally acknowledged Hypomenorrhea in 20ml be hypomenorrhea.
The understanding of Chinese medicine to hypomenorrhea has long history, and ancient Chinese medicine doctor has carried out extensive and deep discussion to aspects such as its cause of disease, pathogenesis, treatments.In Shanxi is for " pulse classic is put down pregnant fetal movement blood system moisture and told lower abdominal pain card " of Wang Shuhe, just there is the record of " few through water ", thinks that its pathogenesis is for " its body fluid of dying ".With " four things four liang add Radix Rehmanniae Preparata, Radix Angelicae Sinensis each one or two " treatment " married woman is through water insufficiency of blood normal complexion person " in Jin Dynasty " Plain Questions pathogenesis gas should be saved one's life and be collected married woman's tire product opinion "." Standards of Diagnosis and Treatment female section regulating menstruation door " is pointed out: " a small amount of menses and menstruating unsmoothly, for void is puckery, deficiency syndrome should be treated by tonifying method, puckery, moisten it." motherland's medical science thinks that this Anttdisease Mechanism has void to have reality.Void person is many because of damage of essence insufficiency of blood, and sea of blood virtual loss is appointed in punching, the weary source of menses; Reality person is many to stop by blood stasis, or stagnation of phlegm-damp, and punching is appointed and is jammed, hematogenous blockage and hypomenorrhea.Clinical to suffer from a deficiency of the kidney, blood deficiency, cold coagulation, blood stasis, phlegm-damp are common.
Modern study shows: hypomenorrhea, and the pathogenic factor of amenorrhea mainly contains: the uterine factors such as uterine hypoplasia, endometrial tuberculosis, endometritis; The Ovarian factors such as premature ovarian failure or pure gonadal hypoplasia; Hypothalamus gonadotropin releasing hormone or pituitary gonadotropic hormone secretion decline or imbalance; Artificial abortion dilatation and curettage of uterine is crossed the dark or endometrial basal layer of official jargon electrocautery equivalent damage or is caused intrauterine adhesion; Long-term taking some drugs, as oral contraceptive causes hypomenorrhea, the very then many factors such as amenorrhea.
One of artificial abortion reason causing hypomenorrhea is exactly postoperatively cause endometrial inflammation treatment and form chronic inflammatory disease and too early sexual intercourse post-abortion not in time and cause endometrial inflammation, especially common with pelvic inflammatory disease, when pelvic inflammation has influence on endometrium, by interior neural reflex, inner membrance is caused to secrete bad, Estrogen and progestin imbalance or inner membrance in resting state to gonadal hormone reaction, all can make inner membrance faulty restoration and not generating period change, thus cause hypomenorrhea.
Chinese traditional treatment primary disease shows unique characteristics, and can reach the object for the treatment of, can avoid again the toxic and side effects of Western medicine.Recent study result shows, Chinese medicine, while treatment hypomenorrhea, can also improve ovarian function, have significant late result advantage.Therefore develop the pharmaceutical preparation that effect treats hypomenorrhea more to be significantly significant.
Summary of the invention
In order to solve the problem, the present invention aims to provide the pharmaceutical preparation its preparation method of the hypomenorrhea that a kind for the treatment of is caused by pelvic inflammatory disease.
An object of the present invention is to provide the pharmaceutical preparation of the hypomenorrhea that a kind for the treatment of is caused by pelvic inflammatory disease.
Inventor combines theory and the clinical experience of oneself of the sage of the past at all times, by modern physiological pathology and pathogen and pathology of tcm, dialectically to combine with differential diagnosis of diseases, the pharmaceutical preparation of the hypomenorrhea that a kind for the treatment of provided is caused by pelvic inflammatory disease, by Herba Clematidis loureirianae, Caulis Seu Folium Euonymi Fortunei, Radix Et Caulis Acanthopanacis Senticosi, Radix Dipsaci, Semen Cuscutae, Radix seu Caulis Embeliae Parviflorae, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Radix Codonopsis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae is that medicinal raw material is made, in side, the weight of each medicinal raw material is as follows: Herba Clematidis loureirianae 10-20 part, Caulis Seu Folium Euonymi Fortunei 15-35 part, Radix Et Caulis Acanthopanacis Senticosi 10-18 part, Radix Dipsaci 5-15 part, Semen Cuscutae 15-30 part, Radix seu Caulis Embeliae Parviflorae 8-28 part, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 10-30 part, Radix Codonopsis 10-20 part, Pericarpium Citri Reticulatae 5-15 part, Radix Glycyrrhizae 1-10 part.
Fang Zhong: Herba Clematidis loureirianae is sweet light flat, kind clearing away heat and promoting diuresis, expelling wind and removing dampness; The bitter sweet micro-pungent tepor of Caulis Seu Folium Euonymi Fortunei, kind relaxing muscles and tendons and activating QI and blood in the collateral, kidney tonifying strengthens waist, two medicine compatibility expelling wind and removing dampness, activating blood circulation and dissipating blood stasis, actively stimulates the menstrual flow as monarch drug, and two flavour of a drug are sweet can mend, and dehumidifying is purged heat, promoting blood circulation to remove blood stasis and do not hinder this.The pungent micro-bitter temperature of Radix Et Caulis Acanthopanacis Senticosi, replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization; Radix Dipsaci toil tepor, invigorating the liver and kidney, bone and muscle strengthening, mends continuous blood vessels, and can continue wound and QI and blood regulating absolutely, the sweet temperature of Semen Cuscutae, the kidney invigorating nourishing the liver, warming the spleen helps stomach, in fact can be in order to, cold can be warm, heat can be cool, and wetting can be dry, dryly can moisten; Radix seu Caulis Embeliae Parviflorae stimulates the menstrual flow, and invigorates blood circulation, tonify deficiency labor, strong waist knee joint, nourishing essence and tonifying YANG, four medicine 5 use, invigorating the liver and kidney, bone and muscle strengthening, mends intensive culture blood, contributes to invigorating blood circulation, and also contribute to dehumidifying, cold relieving dredging collateral is ministerial drug.Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) circulation of qi promoting is nourished blood, regulating menstruation; Radix Codonopsis energy spleen reinforcing nourishing the stomach, the lung moistening and production of body fluid promoting, gas in strong fortune, and partially do not grow greasy, inspires clear sun, gas in vibration and not wetting, and Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, solid protection the foundation of acquired constitution, makes transporting and transforming function of the spleen and stomach strong, and phlegm-damp not life, circulation of qi promoting is nourished blood and is adjuvant drug.Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription is adjuvant.All medicines interact, and are mutually use, play special effect, play expelling wind and removing dampness altogether, activating blood circulation and dissipating blood stasis, temperature compensation QI and blood, the effect of dredge the meridian passage, have unique effect to the hypomenorrhea that pelvic inflammation causes.Clinical observation finds, observation group uses the rear cure rate of invention formulation treatment, effective percentage high, and be significantly higher than matched group, safety is simultaneously high, side effect is little.
Further preferably, treat a pharmaceutical preparation for the hypomenorrhea caused by pelvic inflammatory disease, it is characterized in that being made up of the medicinal raw material of following weight: Herba Clematidis loureirianae 13-18 part, Caulis Seu Folium Euonymi Fortunei 25-30 part, Radix Et Caulis Acanthopanacis Senticosi 12-16 part, Radix Dipsaci 8-13 part, Semen Cuscutae 25-30 part, Radix seu Caulis Embeliae Parviflorae 10-18 part, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15-20 part, Radix Codonopsis 11-16 part, Pericarpium Citri Reticulatae 6-11 part, Radix Glycyrrhizae 6-10 part.
Further preferably, treat a pharmaceutical preparation for the hypomenorrhea caused by pelvic inflammatory disease, it is characterized in that being made up of the medicinal raw material of following weight: Herba Clematidis loureirianae 15 parts, Caulis Seu Folium Euonymi Fortunei 25 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Radix Dipsaci 10 parts, Semen Cuscutae 27 parts, Radix seu Caulis Embeliae Parviflorae 16 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 18 parts, Radix Codonopsis 12 parts, Pericarpium Citri Reticulatae 8 parts, 7 parts, Radix Glycyrrhizae.
The pharmaceutical research present situation of the present invention's each medical material used is as described below.
Herba Clematidis loureirianae: [nature and flavor] sweet in the mouth; Light; Property is put down.[return through] returns liver; Kidney; Urinary bladder channel.[function cures mainly] clearing away heat and promoting diuresis; Promoting blood circulation to restore menstrual flow; Expelling wind and removing dampness.Main dysuria; Edema; Damp-heat gonorrhoea; Rheumatic arthralgia; Traumatic injury; Scorching on wind-fire; Eye red pain; Amenorrhea; Mange.
Caulis Seu Folium Euonymi Fortunei: [nature and flavor] are bitter; Sweet; Micro-pungent; Tepor.[return through] liver; Spleen; Kidney channel.[function cures mainly] relaxing muscles and tendons and activating QI and blood in the collateral; Kidney tonifying strengthens waist; Hemostasis repercussive.Main soreness of waist and knee joint of suffering from a deficiency of the kidney; Hemiplegia; Rheumatic arthralgia; Infantile convulsion; Spitting of blood; Spit blood; Metrorrhagia; Have through uncomfortable; Uterine prolapse; Injury and bone fracture; Wound hemorrhage.
Radix Et Caulis Acanthopanacis Senticosi: [nature and flavor] pungent, micro-hardship, temperature.[return through] returns spleen, kidney, heart channel.[function cures mainly] replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.
Radix Dipsaci: [nature and flavor] are bitter, pungent, tepor.[return through] returns liver, kidney channel.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.For soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down.
Semen Cuscutae: [nature and flavor] are sweet, temperature.[return through] returns liver,kidney,spleen warp.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Radix seu Caulis Embeliae Parviflorae: [nature and flavor] are bitter; Puckery; Warm in nature.[return through] liver; Kidney channel.[function cures mainly] enriches blood; Invigorate blood circulation; Strong waist knee joint.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Puerperal asthenia; Waist and leg ache; Injury and bone fracture.
Cyperus michelianus(L.) Link (Herba Cyperi Micheliani): [nature and flavor] acrid in the mouth; Light; Property is put down.[return through] liver; Spleen channel.[function cures mainly] circulation of qi promoting is nourished blood; Regulating menstruation.Main menoxenia; Dysmenorrhea.
Radix Codonopsis: [nature and flavor] are sweet is flat.[return through] returns spleen, lung meridian.[function cures mainly] invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Pericarpium Citri Reticulatae: [nature and flavor] are bitter, pungent, temperature.[return through] returns lung, spleen channel.[function cures mainly] regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Radix Glycyrrhizae: [nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
The pharmaceutical preparation that the present invention treats the hypomenorrhea caused by pelvic inflammatory disease can also contain pharmaceutically acceptable carrier, be prepared into peroral dosage form, as: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution or plaster etc.
The peroral dosage form of pharmaceutical preparation further preferably of the present invention is tablet, capsule or granule, most preferably is capsule.
Pharmaceutically acceptable carrier described above, can be selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
The preparation method that the present invention treats the pharmaceutical preparation of the hypomenorrhea caused by pelvic inflammatory disease comprises following steps: take each Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; First time adds 8 times amount soak by water 3h, and second time adds 6 times amount soak by water 2h, filters; When filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.03 ~ 1.08, slowly ethanol is added under stirring when being chilled to 40 DEG C, alcohol content is made to reach 50%v/v, leave standstill 24 hours, leaching supernatant, reclaim ethanol to without alcohol taste, be directly used as medicine to use or add appropriate amount of auxiliary materials through normal process steps and make clinical acceptable dosage form.
The present invention relatively and prior art, has following clear superiority:
Selected by invention medicine, medical material compatibility is suitable, meets Chinese medicine and pharmacy and modern medicine theory, and comprehensively, medication is thoughtful in legislation, play special effect, play expelling wind and removing dampness altogether, activating blood circulation and dissipating blood stasis, temperature compensation QI and blood, the effect of dredge the meridian passage, has unique effect to the hypomenorrhea that pelvic inflammation causes.Clinical observation finds, observation group uses the rear cure rate of invention formulation treatment, effective percentage high, is significantly higher than matched group.
Traditional Chinese medicine preparation of the present invention has Mutiple Targets, too many levels, multi-level comprehensive regulation effect, and side effect is less, and patient compliance is better, taking convenience, can effectively alleviate patient's burden and misery, the object for the treatment of both the principal and secondary aspects of a disease can be reached, wide popularization and application on clinic.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 capsule
Prescription: Herba Clematidis loureirianae 15 parts, Caulis Seu Folium Euonymi Fortunei 25 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Radix Dipsaci 10 parts, Semen Cuscutae 27 parts, Radix seu Caulis Embeliae Parviflorae 16 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 18 parts, Radix Codonopsis 12 parts, Pericarpium Citri Reticulatae 8 parts, 7 parts, Radix Glycyrrhizae.
Preparation method: take each Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; First time adds 8 times amount soak by water 3h, and second time adds 6 times amount soak by water 2h, filters; When filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.03 ~ 1.08, slowly adds ethanol, make alcohol content reach 50%v/v when being chilled to 40 DEG C under stirring, leave standstill 24 hours, leaching supernatant, reclaims ethanol to without alcohol taste, adds appropriate amount of auxiliary materials make capsule through normal process steps.
The capsule that the present embodiment is obtained, every containing crude drug 1.5g.
Embodiment 2 capsule
Prescription: Herba Clematidis loureirianae 13 parts, Caulis Seu Folium Euonymi Fortunei 25 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, Radix Dipsaci 12 parts, Semen Cuscutae 25 parts, Radix seu Caulis Embeliae Parviflorae 10 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15 parts, Radix Codonopsis 12 parts, Pericarpium Citri Reticulatae 8 parts, 7 parts, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 3 capsule
Prescription: Herba Clematidis loureirianae 16 parts, Caulis Seu Folium Euonymi Fortunei 28 parts, Radix Et Caulis Acanthopanacis Senticosi 16 parts, Radix Dipsaci 8 parts, Semen Cuscutae 30 parts, Radix seu Caulis Embeliae Parviflorae 18 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 12 parts, Radix Codonopsis 15 parts, Pericarpium Citri Reticulatae 9 parts, 9 parts, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 4 capsule
Prescription: Herba Clematidis loureirianae 18 parts, Caulis Seu Folium Euonymi Fortunei 35 parts, Radix Et Caulis Acanthopanacis Senticosi 18 parts, Radix Dipsaci 12 parts, Semen Cuscutae 20 parts, Radix seu Caulis Embeliae Parviflorae 20 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15 parts, Radix Codonopsis 18 parts, Pericarpium Citri Reticulatae 12 parts, 6 parts, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 5 capsule
Prescription: Herba Clematidis loureirianae 10 parts, Caulis Seu Folium Euonymi Fortunei 20 parts, Radix Et Caulis Acanthopanacis Senticosi 13 parts, Radix Dipsaci 8 parts, Semen Cuscutae 20 parts, Radix seu Caulis Embeliae Parviflorae 12 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 12 parts, Radix Codonopsis 12 parts, Pericarpium Citri Reticulatae 5 parts, 3 parts, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 6 capsule
Prescription: Herba Clematidis loureirianae 13 parts, Caulis Seu Folium Euonymi Fortunei 20 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, Radix Dipsaci 15 parts, Semen Cuscutae 15 parts, Radix seu Caulis Embeliae Parviflorae 10 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15 parts, Radix Codonopsis 15 parts, Pericarpium Citri Reticulatae 10 parts, 5 parts, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 7 capsule
Prescription: Herba Clematidis loureirianae 18 parts, Caulis Seu Folium Euonymi Fortunei 23 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, Radix Dipsaci 12 parts, Semen Cuscutae 30 parts, Radix seu Caulis Embeliae Parviflorae 15 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 20 parts, Radix Codonopsis 12 parts, Pericarpium Citri Reticulatae 6 parts, 6 parts, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 8 capsule
Prescription: Herba Clematidis loureirianae 18 parts, Caulis Seu Folium Euonymi Fortunei 30 parts, Radix Et Caulis Acanthopanacis Senticosi 14 parts, Radix Dipsaci 12 parts, Semen Cuscutae 15 parts, Radix seu Caulis Embeliae Parviflorae 28 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 25 parts, Radix Codonopsis 20 parts, Pericarpium Citri Reticulatae 12 parts, 6 parts, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 9 granule
Prescription: Herba Clematidis loureirianae 15 parts, Caulis Seu Folium Euonymi Fortunei 25 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Radix Dipsaci 10 parts, Semen Cuscutae 27 parts, Radix seu Caulis Embeliae Parviflorae 16 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 18 parts, Radix Codonopsis 12 parts, Pericarpium Citri Reticulatae 8 parts, 7 parts, Radix Glycyrrhizae.
Preparation method: take each Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; First time adds 8 times amount soak by water 3h, and second time adds 6 times amount soak by water 2h, filters; When filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.03 ~ 1.08, slowly adds ethanol, make alcohol content reach 50%v/v when being chilled to 40 DEG C under stirring, leave standstill 24 hours, leaching supernatant, reclaims ethanol to without alcohol taste, adds appropriate amount of auxiliary materials make granule through normal process steps.
Embodiment 10 tablet
Prescription: Herba Clematidis loureirianae 15 parts, Caulis Seu Folium Euonymi Fortunei 25 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Radix Dipsaci 10 parts, Semen Cuscutae 27 parts, Radix seu Caulis Embeliae Parviflorae 16 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 18 parts, Radix Codonopsis 12 parts, Pericarpium Citri Reticulatae 8 parts, 7 parts, Radix Glycyrrhizae.
Preparation method: take each Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; First time adds 8 times amount soak by water 3h, and second time adds 6 times amount soak by water 2h, filters; When filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.03 ~ 1.08, slowly adds ethanol, make alcohol content reach 50%v/v when being chilled to 40 DEG C under stirring, leave standstill 24 hours, leaching supernatant, reclaims ethanol to without alcohol taste, adds appropriate amount of auxiliary materials make tablet through normal process steps.
Test example 1 clinical observation is tested
1 data and method
1.1 physical data: observe year April in August, 2014 to 2015 and go to a doctor in my institute's Out-patient Clinic of Department of Gynecology, a small amount of hydrops of B ultrasonic prompting pelvic cavity, has abortion history, simultaneously with patient 128 example of hypomenorrhea card, is divided into observation group and matched group to observe at random, often organizes 64 examples.Observation group's age 18-to 34-year-old, 23.2 ± 3.8 years old mean age, matched group age 18-33 year, average 22.9 ± 3.6 years old; Observation group's course of disease is the longest 4.5 years, the shortest 6 months, average 1.05 ± 1.08 years, the matched group course of disease is the longest 4.5 years, the shortest 5 months, average 1.06 ± 1.01 years, two groups of physical data compare no difference of science of statistics (P > 0.05), have comparability.
1.2 diagnostic criterias: the diagnostic criteria of writing the hypomenorrhea of " guideline of clinical investigations of new Chinese medicine treatment menoxenia " of " Gynecology of Chinese Medicine " and Ministry of Health of the People's Republic of China promulgation in 2002 according to Zhang Yuzhen etc.
Hypomenorrhea: hypomenorrhea refers to that menstrual cycle is normal, and menstrual blood loss comparatively constant obviously reduces, and even drop is namely clean, or through line time less than 2 days, through the menopathy that amount is also few.
1.3 exclusion standards: have cryptorrhea, luteal phase defect; There are the Chronic consumptions persons such as hyperthyroidism, tuberculosis, severe anemia; There is oral hormone in 3 months, use contraceptive person; Untoward reaction person is there is in drug administration process; Not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or statistical disposition person.
1.4 Therapeutic Method:
Observation group: the capsule that menstruation brings into use the embodiment of the present invention 1 to prepare on the 5th day, 2-4 grain, took and withdrew to during menstrual onset every day, is a course for the treatment of, takes 3 months continuously with 3 months.
Matched group: use Western medicine capable artificial cycle estrogen and progestogen sequential therapy, from menstruation the 5th day, the oral progynova 1mg of patient, 1 time/d, serve on 21d; Started from the 15th day, add with Progesterone soft gelatin capsule 100mg, 2 times/d, take to the 21st day and progynova drug withdrawal simultaneously.Continuous treatment 3 menstrual cycle.
1.5 observation index:
1.5.1 observe change--menstrual blood volume color, the matter of menstruation before and after two groups of treatments, pass through the time, menstrual cycle.
1.5.2 the therapeutic effect of two groups of patients is observed.
1.5.3 the observation of adverse effect during medication: with or without occurring untoward reaction and record during observing medication, as gastrointestinal upset, anaphylaxis, vaginal bleeding time prolongation etc.As the person that occurs serious adverse reaction, discontinue medication immediately, exit this research.
1.5.4 following up a case by regular visits to property observation: treatment is followed up a case by regular visits to after terminating rear third time menstrual onset, record related symptoms is observed.
1.6 statistical methods: adopt SPSS15.0 statistical software to calculate.Each numerical value with represent, measurement data adopts t inspection, and enumeration data adopts χ 2inspection, with P < 0.05 for difference has statistical significance.
2 results
2.1 criterions of therapeutical effect: according to " guideline of clinical investigations of new Chinese medicine treatment menoxenia ", draft following criterion of therapeutical effect: recovery from illness: treat rear menstrual cycle, recover normal through amount, other transference cures, drug withdrawal 3 non-recidivists of menstrual cycle.Effective: menstrual blood volume increases by 1/3, and other transference cures alleviate, integration reduces more than 70% before comparatively treating, and drug withdrawal 3 menstrual cycle are without recidivist.Effective: treat rear menstrual cycle, through amount, comparatively treat front improvement menstrual period, other symptoms alleviate before comparatively treating, integration reduces 30 ~ 69% before comparatively controlling.Invalid: treatment after menstrual cycle, through amount and menstrual period without improvement, integration comparatively treat before reduce less than 30%.
2.2 observation of curative effect
2.2.1 two groups of patient's comparitive study: observation group's recovery from illness 23 example, effective 26 examples, effective 14 examples, invalid 1 example, obvious effective rate 76.6%, total effective rate 98.4%; Matched group recovery from illness 10 example, effective 20 examples, effective 20 examples, invalid 14 examples, obvious effective rate 46.9%, total effective rate 78.1%, observation group compares with matched group obvious effective rate, total effective rate, difference has statistical significance (P < 0.05), illustrates that clinical cure rate and the obvious effective rate of hypomenorrhea significantly can improve compared with matched group in observation group.In table 1.
Table 1 liang group patient comparitive study (n%, example)
Note: compare with matched group, * P < 0.05.
2.2.2 after two groups of treatments, Follow-up results compares
Time after treatment is finished to effective follow-up of patients, routine patient menstrual is normal in observation group 48, there is 1 routine patient when following up a case by regular visits to, hypomenorrhea, and in the routine patient of matched group 30, have 15 routine patient menstrual normal, there are 12 routine patient menstrual very few, 3 routine patient's amenorrheas, illustrate that the patient of matched group clinical symptoms after drug withdrawal has bounce-back.Can illustrate that observation group compares with matched group and has better late result accordingly, and the clinical symptoms of patient not easily recurs, and also demonstrates pharmaceutical preparation of the present invention and can treat the hypomenorrhea caused by pelvic inflammatory disease, makes body obtain good recovery.
2.2.3 the observation of adverse effect during medication: have 1 routine patient to occur slight gastrointestinal reaction during observation group's patient medication.18 routine patients are had to occur slight gastrointestinal reaction during matched group patient medication, as Nausea and vomiting, upper abdomen dull pain; Have 3 routine patients to occur irregular colporrhagia, observation group compares with matched group, and difference has statistical significance, and observation group's less adverse effect, patient compliance is better.
Therapeutic outcome shows: observation group can significantly improve clinical cure rate and the obvious effective rate of the hypomenorrhea caused by pelvic inflammatory disease compared with matched group; Have better late result, and the clinical symptoms of patient not easily recurs, untoward reaction is few, is one pharmaceutical preparation safely and effectively, for Chinese medicine hypomenorrhea provides new method, is worth studying and applying further.
Model case:
Zhao, female, 31 years old, Hypomenorrhea more than 1 year.Previously menstruation rule, menophania 15 years old, in 28 ~ 30 days cycles, in 3 ~ 5 days menstrual period, amount can.Within nearly more than, amount in the period, 1 reduces gradually, drop and under, question closely medical history, to learn before more than 1 year the once row uterine curettage because of unplanned pregnancy, so far occur infrequent menstruation.Last menstrual period in May, 2013, amount is few, protective pad can, color is dark red, and drop 2 days is namely clean, companion's soreness of the waist and knees, hyposexuality, the dark thin fur of tongue, thready and stringy pulse.Gynecologial examination: pudendum: the married type of product; Vagina: unobstructed, secretions is slightly many, transparent rare clearly; Cervix uteri: smooth; Gong Ti: rear position, Chang great, in matter, activity can; Adnexa: left and right adnexa is not and obviously abnormal.B ultrasonic is pointed out: a small amount of hydrops of pelvic cavity.Tcm diagnosis: hypomenorrhea.Use capsule prepared by the embodiment of the present invention 1, every day 2 times, each 2, after one month, symptom obviously alleviates, and menstrual blood volume is gradually many, takes and terminates to the course for the treatment of, when following up a case by regular visits to, inform that menstrual blood volume has recovered normal, and all the other malaise symptoms disappears all.

Claims (10)

1. treat the pharmaceutical preparation of the hypomenorrhea caused by pelvic inflammatory disease for one kind, it is characterized in that by Herba Clematidis loureirianae, Caulis Seu Folium Euonymi Fortunei, Radix Et Caulis Acanthopanacis Senticosi, Radix Dipsaci, Semen Cuscutae, Radix seu Caulis Embeliae Parviflorae, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani), Radix Codonopsis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae be that medicinal raw material is made, in side, the weight of each medicinal raw material is as follows: Herba Clematidis loureirianae 10-20 part, Caulis Seu Folium Euonymi Fortunei 15-35 part, Radix Et Caulis Acanthopanacis Senticosi 10-18 part, Radix Dipsaci 5-15 part, Semen Cuscutae 15-30 part, Radix seu Caulis Embeliae Parviflorae 8-28 part, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 10-30 part, Radix Codonopsis 10-20 part, Pericarpium Citri Reticulatae 5-15 part, Radix Glycyrrhizae 1-10 part.
2. pharmaceutical preparation as claimed in claim 1, is characterized in that being made up of the medicinal raw material of following weight: Herba Clematidis loureirianae 13-18 part, Caulis Seu Folium Euonymi Fortunei 25-30 part, Radix Et Caulis Acanthopanacis Senticosi 12-16 part, Radix Dipsaci 8-13 part, Semen Cuscutae 25-30 part, Radix seu Caulis Embeliae Parviflorae 10-18 part, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15-20 part, Radix Codonopsis 11-16 part, Pericarpium Citri Reticulatae 6-11 part, Radix Glycyrrhizae 6-10 part.
3. pharmaceutical preparation as claimed in claim 2, is characterized in that being made up of the medicinal raw material of following weight: Herba Clematidis loureirianae 15 parts, Caulis Seu Folium Euonymi Fortunei 25 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Radix Dipsaci 10 parts, Semen Cuscutae 27 parts, Radix seu Caulis Embeliae Parviflorae 16 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 18 parts, Radix Codonopsis 12 parts, Pericarpium Citri Reticulatae 8 parts, 7 parts, Radix Glycyrrhizae.
4. the pharmaceutical preparation as described in claim 1-3, is characterized in that described pharmaceutical preparation is prepared into peroral dosage form.
5. pharmaceutical preparation as claimed in claim 4, is characterized in that described peroral dosage form is tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, sucks agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution or plaster etc.
6. pharmaceutical preparation as claimed in claim 5, is characterized in that described peroral dosage form is preferably as tablet, capsule or granule.
7. pharmaceutical preparation as claimed in claim 6, is characterized in that described peroral dosage form is preferably capsule.
8. the pharmaceutical preparation as described in claim 1-3, is characterized in that the preparation method of described pharmaceutical preparation comprises following steps: take each Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; First time adds 8 times amount soak by water 3h, and second time adds 6 times amount soak by water 2h, filters; When filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.03 ~ 1.08, slowly adds ethanol, make alcohol content reach 50%v/v when being chilled to 40 DEG C under stirring, leave standstill 24 hours, leaching supernatant, reclaims ethanol to without alcohol taste, adds appropriate amount of auxiliary materials make clinical acceptable dosage form through normal process steps.
9. the application in the medicine of the hypomenorrhea caused by pelvic inflammatory disease is treated in the pharmaceutical preparation described in claim 1-3 in preparation.
10. the application of the pharmaceutical preparation described in claim 1-3 in the medicine of preparation treatment hypomenorrhea.
CN201610004550.XA 2016-01-04 2016-01-04 Medicinal preparation for treating hypomenorrhea caused by pelvic inflammation Withdrawn CN105434766A (en)

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Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
吴凌燕等: "浅谈月经过少从盆腔炎症论治", 《四川中医》 *
步东南: "《草庐医录：步连珍五十年中医临证精要》", 30 April 2015, 中国中医药出版社 *

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Application publication date: 20160330