CN105596631A - Pharmaceutical preparation for treating hypomenorrhea caused by contraceptives - Google Patents
Pharmaceutical preparation for treating hypomenorrhea caused by contraceptives Download PDFInfo
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- CN105596631A CN105596631A CN201610015295.9A CN201610015295A CN105596631A CN 105596631 A CN105596631 A CN 105596631A CN 201610015295 A CN201610015295 A CN 201610015295A CN 105596631 A CN105596631 A CN 105596631A
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Abstract
The invention belongs to the field of traditional Chinese medicines and relates to a pharmaceutical preparation for treating hypomenorrhea caused by contraceptives. The pharmaceutical preparation is prepared from medicinal raw materials including radix rehmannia glutinosa, medicinal indianmulberry roots, Chinese dodder seeds, Chinese wolfberry fruits, glossy privet fruits, radix dipsaci, salvia miltiorrhiza, whorl-leaf litse roots, Szechwan Lovage rhizomes, evergreen mucuna roots and stems, nutgrass galingale rhizomes, a sivery aleuritopteris herb, auriculate swallowwort roots, twotooth achyranthes root and licorice roots. The pharmaceutical preparation has multiple-target, multiple-link and multi-level comprehensive regulation and control effects, multiple factors play a synergistic effect to improve menstruation, the treating effects of patients of an observation group treated by adopting the pharmaceutical preparation are obviously superior to those of a control group, the endometrial thickness after treatment is obviously increased compared with the endometrial thickness before treatment, and the Salle score is obviously improved compared with the Salle score before treatment and is also obviously superior to the Salle score of the control group. Therefore, compared with a western routine treatment method, the clinical treating effect of the pharmaceutical preparation applied to the treatment of the hypomenorrhea caused by the contraceptives is better, the hypomenorrhea situations of the patients are obviously improved, the curative effect is worthy of affirmation, and the pharmaceutical preparation is popularized and applied in clinical treatment.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to the medicine for the treatment of irregular menstruation, relate in particular to one and treat contraceptive and cause month processFew pharmaceutical preparation and preparation method thereof.
Background technology
Hypomenorrhia refers to that the menstrual cycle is normal, and MBV obviously reduces, or the deficiency of time 2d that passes through, even drop is clean person.Hypomenorrhia is as treatment not in time, affect cytula in uterus film plant, cause recurrent abortion, infertile etc., be the forerunner of amenorrhoeaSymptom. Due to modern society's dog-eat-dog, life, operating pressure increase day by day, add repeatedly medicine or artificial of some womenThe factors such as miscarriage, abuse contraceptive, make this sick incidence of disease more and more higher, can develop into amenorrhoea, not as treated not in timeFertility person can affect it and become pregnant.
Menstruation is produce under hypothalamic-pituitary-ovarian axis and uterus genital tract interact periodically hemorrhage, is estrogen and progestogenThe result that the endometrium of periodically withdrawing and cause and blood vessel structure change. Steroid hormonal contraceptive can disturb Hypothalamus-pituitary-The normal function of hypothalamic pituitary ovarium axis, causes the GnRH of hypothalamus secretion to reduce, and pituitary FSH and LH all reduce, self ovarian follicular growth masterRely on exogenous hormones support, and endometrial hyperplasia is bad, Hypomenorrhea.
Western medical treatment hypomenorrhia method is more single, generally adopts hormone therapy, uses female, progestational hormone cycle therapy more, comesExpansion uterine vascular, accelerates UBF speed, repairs impaired endometrium, makes eumenorrhea. But be limited to strict takingTime and larger side effect, make its long-term prescription can produce very strong dependence, and easily recurrence after drug withdrawal, also may cause phaseThe gynecological tumor disease of answering, therefore as routine clinical therapy. Review Chinese traditional treatment, taking dialectical theory as basis, side effectFew, clinical effectiveness is good, and is approved by extensive patients.
Summary of the invention
In order to address the above problem, the present invention aims to provide a kind of pharmaceutical preparation and preparation thereof for the treatment of contraceptive and cause hypomenorrhiaMethod.
An object of the present invention is to provide a kind of pharmaceutical preparation for the treatment of contraceptive and cause hypomenorrhia.
Inventor is the clinical experience with oneself in conjunction with the sage of the past's at all times theory, by modern physiological pathology and pathogen and pathology of tcm, dialecticalCombine with the differentiation of disease, think that it is mainly function disorder that contraceptive causes the Anttdisease Mechanism of hypomenorrhia, the loss of kidney essense gas,Or qi and blood is not smooth, cause punching and appoint a disorder of qi and blood, uterus to hold to overflow not normal, provide a kind of contraceptive for the treatment of to cause hypomenorrhia based on thisPharmaceutical preparation, it is characterized in that by prepared rhizome of rehmannia, Morinda officinalis, the seed of Chinese dodder, the fruit of Chinese wolfberry, the fruit of glossy privet, teasel root, the red sage root, whorlleaf litse root,Ligusticum wallichii, evergreen mucuna root and leaf, rhizoma cyperi, sivery aleuritopteris herb, mountain on the other way round disappear, the root of bidentate achyranthes, Radix Glycyrrhizae are that medicinal raw material is made.
For the synergy of effective active composition in medicine, the inventor, through long-term, a large amount of screening prescription tests, entersOne step is preferably as follows technical scheme:
Treat contraceptive and cause the pharmaceutical preparation of hypomenorrhia, it is characterized in that being made by the medicinal raw material of following weight portion proportioning:
Prepared rhizome of rehmannia 13-26 part, Morinda officinalis 8-18 part, seed of Chinese dodder 5-20 part, fruit of Chinese wolfberry 15-25 part, fruit of glossy privet 15-25 part, teasel root5-10 part, red sage root 6-16 part, whorlleaf litse root 10-20 part, Ligusticum wallichii 5-15 part, evergreen mucuna root and leaf 16-32 part, rhizoma cyperi 8-18 part, sivery aleuritopteris herb 9-19Part, mountain on the other way round disappear 9-19 part, root of bidentate achyranthes 3-8 part, Radix Glycyrrhizae 3-8 part.
Further preferably, a kind of pharmaceutical preparation for the treatment of contraceptive and cause hypomenorrhia, is characterized in that by following weight portion proportioningMedicinal raw material make: prepared rhizome of rehmannia 18-24 part, Morinda officinalis 8-13 part, seed of Chinese dodder 10-15 part, fruit of Chinese wolfberry 15-20 part, the fruit of glossy privet18-23 part, teasel root 6-9 part, red sage root 8-13 part, whorlleaf litse root 10-15 part, Ligusticum wallichii 7-12 part, evergreen mucuna root and leaf 22-28 part, rhizoma cyperi 9-15Part, sivery aleuritopteris herb 13-18 part, mountain on the other way round disappear 10-15 part, root of bidentate achyranthes 4-7 part, Radix Glycyrrhizae 3-8 part.
Further preferably, a kind of pharmaceutical preparation for the treatment of contraceptive and cause hypomenorrhia, is characterized in that by following weight portion proportioningMedicinal raw material make:
20 parts of prepared rhizomes of rehmannia, 10 parts of Morinda officinalis, 12 parts of the seed of Chinese dodders, 18 parts of the fruits of Chinese wolfberry, 20 parts of the fruit of glossy privets, 8 parts of teasel roots, the red sage root 12Part, 10 parts of whorlleaf litse roots, 9 parts of Ligusticum wallichiis, 25 parts of evergreen mucuna root and leafs, 12 parts of rhizoma cyperis, 15 parts of sivery aleuritopteris herbs, mountain on the other way round disappear 15 parts, 6 parts of the roots of bidentate achyranthes,6 parts, Radix Glycyrrhizae.
Fang Xie: monarch drug in a prescription: the sweet tepor of prepared rhizome of rehmannia, nourishing yin and supplementing blood, beneficial essence is filled out marrow, and for controlling the key medicine of the deficiency of liver-yin and kidney-yin, Morinda officinalis is pungent sweetTepor, tonifies the kidney and support yang, dispels rheumatism, and strengthening the muscles and bones, two medicine compatibility nourishment for vitalities, treating YANG within YIN, beneficial essence is filled out marrow.
Ministerial drug: the sweet temperature of the seed of Chinese dodder, nourishing liver and kidney, controlling nocturnal emission with astringent drugs contracting urine; The fruit of Chinese wolfberry is sweet flat, nourishing liver and kidney; The fruit of glossy privet is bitter sweet flat, mendsLiver kidney, strong waist knee; Teasel root tonifies the liver and kidney, and strong strong bone is promoting blood circulation, four medicine 5 use filling liver kidney, and strengthening the bones and muscles, principal drug assistance,Coordinating Chong and Conception Vessels.
Adjutant: red sage root hardship is slightly cold, stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire; Whorlleaf litse root dispelling wind and removing obstruction in the meridians, activating blood circulation and reducing swelling;The pungent temperature of Ligusticum wallichii, blood-activating and qi-promoting, wind-expelling pain-stopping; The bitter micro-bitter temperature of evergreen mucuna root and leaf, promoting blood circulation for regulating menstruation, the relaxing muscles and tendons of enriching blood, rhizoma cyperi promoting the circulation of qi solutionStrongly fragrant, menstruction regulating and pain relieving; Sivery aleuritopteris herb activating blood to promote menstruation, eliminating damp, detoxifying detumescence; The mountain on the other way round filling liver kidney that disappears, strengthening the bones and muscles, strengthening the spleen and stomach, allMedicine 5 use have warm venting QI-blood, promoting blood circulation and removing blood stasis, active effect of stimulating the menstrual flow.
Adjuvant: root of bidentate achyranthes filling liver kidney, strengthening the bones and muscles, stimulates the menstrual flow by the stasis of blood, ensurings proper downward flow of the blood; Radix Glycyrrhizae is invigorated the spleen and benefited qi, clearing heat and detoxicating, eliminates the phlegmCough-relieving, relieving spasm to stop pain, coordinating the drug actions of a prescription.
All medicines, combined into it, have liver-kidney tonifying, and life essence-filling, marrow-benefitting is promoting blood circulation and removing blood stasis, by nourishing, balance kidney yin kidney yang, and conditioningPunching is appointed, and makes menstruation recovery as before.
Further, in Chinese medicine composition of the present invention, the function of each bulk drug and function cure mainly as described below.
The red sage root: [nature and flavor] hardship, is slightly cold. [return through] thoughts of returning home, Liver Channel. [function cures mainly] stasis-dispelling and pain-killing, activating blood to promote menstruation,Relieving restlessness clears away heart-fire. For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, vexedEgersis; Hepatosplenomegaly, angina pectoris. [usage and dosage] 9～15g.
Whorlleaf litse root: [source] medicinal material Ji Yuan: be the cauline leaf of canella wheel blade Litsea pungens. [nature and flavor] hardship; Pungent; Temperature.[return through] lung; Liver Channel. [function cures mainly] dispelling wind and removing obstruction in the meridians; Activating blood circulation and reducing swelling; Pain relieving. Main air wet arthritis; Pain in waist and lower extremities;Quadriplegia; Dysmenorrhoea; Treating swelling and pain by traumatic injury.
Ligusticum wallichii: [nature and flavor] are pungent, temperature. [return through] returns liver, courage, pericardium channel. [function cures mainly] blood-activating and qi-promoting, only dispels the windBitterly. For irregular menstruation, through closing dysmenorrhoea, abdominal mass stomachache, the shouting pain of the chest side of body, tumbling and swelling, headache, arthralgia due to wind-dampness.
Evergreen mucuna root and leaf: [nature and flavor] hardship; Micro-hardship; Warm in nature. [return through] liver; Stomach warp. [function cures mainly] promoting blood circulation for regulating menstruation; The relaxing muscles and tendons of enriching blood.Main have through uncomfortable; Dysmenorrhoea; Amenorrhoea; Postpartum the deficiency of blood; Anaemia; Arthralgia due to wind-dampness; Numb limb; Traumatic injury. [usage and dosage]For oral administration: to decoct soup, 15-30g, or infusing drugs in wine. External application: appropriate, smash deposited.
The seed of Chinese dodder: [nature and flavor] are sweet, temperature. [return through] returns liver,kidney,spleen warp. [function cures mainly] is nourishing liver and kidney, controlling nocturnal emission with astringent drugs contractingUrine, antiabortive, improving eyesight, antidiarrheal. For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness and weakness of waist and knees, blurred vision tinnitus, suffers from a deficiency of the kidneyThreatened abortion, fetal irritability, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
The fruit of Chinese wolfberry: [nature and flavor] are sweet is flat. [return through] returns liver, kidney channel. [function cures mainly] is nourishing liver and kidney, benefiting shrewd head. Be used forConsumptive disease essence is lost, soreness of waist and knee joint, and dizzy tinnitus, interior heat is quenched one's thirst, and the deficiency of blood is sallow, and blurred vision is not clear.
The fruit of glossy privet: [nature and flavor] are bitter, sweet, flat, nontoxic. [return through] returns liver, kidney, lung channel. [function cures mainly] filling liver kidney,Strong waist knee. Cure mainly: yin asthenia generating intrinsic heat, dizziness, order flower, tinnitus, soreness and weakness of waist and knees, poliosis.
Prepared rhizome of rehmannia: [nature and flavor] are sweet, tepor. [return through] returns liver, kidney channel. [function cures mainly] nourishing yin and supplementing blood, beneficial essence is filled out marrow.For the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat seminal emission, interior heat is quenched one's thirst, and the deficiency of blood is sallow, palpitation and severe palpitation, menstruation is notAdjust, metrostaxis, dizzy, tinnitus, poliosis. [usage and dosage] 9～15g.
Teasel root: [nature and flavor] are bitter, pungent, tepor. [return through] returns liver, kidney channel. [function cures mainly] filling liver kidney; Strengthening the bones and muscles;Adjust blood vessels; Continuous injured; Only uterine bleeding. Teasel root has the effect of apocenosis, hemostasis, analgesia, promotion regeneration. The sweet temperature of this product is supporing yang,Xin Wen is loose cold, with controlling the insufficiency of the kidney yang, and below element deficiency and cold, impotence erectile problem, seminal emission lingering diarrhea, the diseases such as enuresis frequent micturition, have concurrently and tonify the liver and kidney,Strong strong bone, promoting blood circulation merit. Normal and saline cistanche, the medeas such as the seed of Chinese dodder are with using.
Morinda officinalis: [nature and flavor] are pungent, sweet; Tepor. [return through] returns kidney channel, Liver Channel. [function cures mainly] tonifies the kidney and support yang, and dispelsWind dehumidifying, strengthening the muscles and bones. Morinda officinalis is sweet pungent warm in nature, and Gan Wenneng mends, pungent Wen Nengrun, can warming kidney to invigorate yang benefit essence, often join barrenwort,Thizoma curculiginis.
Rhizoma cyperi: [nature and flavor] pungent, micro-hardship, micro-sweet, flat. [return through] returns liver, spleen, tri-jiao channel. [function cures mainly] promoting the circulation of qi solutionStrongly fragrant, menstruction regulating and pain relieving. For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, chest gastral cavity ruffian is vexed, cold hernia stomachache, breastDistending pain, irregular menstruation, through closing dysmenorrhoea. [usage and dosage] 6～9g.
Sivery aleuritopteris herb: [nature and flavor] are pungent; Sweet; Flat. [return through] lung; Liver Channel. [function cures mainly] expelling phlegm and arresting coughing; Activating blood to promote menstruation; ProfitWet; Removing toxicity for detumescence. Main cough; Irregular menstruation; Through closing stomachache; Leukorrhea with reddish discharge; Tuberculosis hemoptysis; Stool diarrhea; Difficulty and pain in micturition;Lung carbuncle; Acute mastitis; Rheumatic arthritis; Traumatic injury; Intercostal neuralgia; Epidemic conjunctivitis; Sore is swollen. [usage and dosage] is for oral administration: decoctSoup, 9-15g. External application: appropriate, decocting is smoked to be washed; Or smash deposited.
Mountain on the other way round disappears: Radix cynanchi wilfordii, mountain on the other way round cynanchum auriculatum Royle ex Wight, radix cynanchi bungei, the white fleece-flower root, mountain Snakegourd Fruit. [nature and flavor] taste is sweet; Micro-hardship; PropertyTepor; [return through] spleen; Stomach; Kidney channel. [function cures mainly] filling liver kidney; Strengthening the bones and muscles; Strengthening the spleen and stomach; Removing toxic substances. Main liver kidney two void;Feel dizzy; Insomnia forgetfulness; Poliosis; Impotence; Seminal emission; The acid of waist knee is climbed; Spleen insufficiency; Abdominal fullness and distention; Ren is wanted notShake; Have loose bowels; Postpartum, breast was few; Lymphogranuloma inguinale sore.
The root of bidentate achyranthes: [nature and flavor] are bitter, sour is flat. [return through] returns liver, kidney channel. [function cures mainly] filling liver kidney, strengthening the bones and muscles, by the stasis of bloodStimulate the menstrual flow, ensuring proper downward flow of the blood. For soreness of waist and knee joint, muscles and bones is unable, through closing abdominal mass, dizziness due to hyperactivity of liver-YANG.
Radix Glycyrrhizae: [nature and flavor] are sweet, flat. [return through] thoughts of returning home, lung, spleen, stomach warp. [function cures mainly] invigorates the spleen and benefits qi, heat-clearing solutionPoison, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription. For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavityAbdomen, the anxious pain of four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
The present invention also provides the preparation method of this pharmaceutical preparation, and it comprises the steps: described prepared rhizome of rehmannia, Morinda officinalis, TuSilk, the fruit of Chinese wolfberry, the fruit of glossy privet, teasel root, the red sage root, whorlleaf litse root, Ligusticum wallichii, evergreen mucuna root and leaf, rhizoma cyperi, sivery aleuritopteris herb, mountain on the other way round disappear, oxKnee, Radix Glycyrrhizae mix in prescription ratio, add the water with respect to 4～10 times of mixture qualities, decoct 2～3 hours, filter and obtain firstExtract; Filter the dregs of a decoction that obtain and add again the water with respect to 2～4 times of described dregs of a decoction quality, decocts 1～2 hour, filter acquisition theTwo extracts; The first extract and the second extract are merged, reduced pressure concentration, dry, obtain and get dry extract, cream is placed on to ultra microIn pulverizer, pulverize 1～2 hour, pulverize, sieve, obtain 100-200 object fine powder, add pharmaceutically acceptable auxiliary material or auxiliaryHelping property composition prepares according to pharmaceutical preparation common process.
Described pharmaceutically acceptable carrier or complementary composition, as starch, Icing Sugar, dextrin, microcrystalline cellulose, compressibility are formed sedimentPowder, dolomol, superfine silica gel powder, fructose, sodium carboxymethyl starch, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, plantThing oil, lecithin, polyethylene glycol, propane diols, ethylparaben etc.
The formulation of described pharmaceutical preparation is peroral dosage form, such as, tablet, film coated tablet, enteric coated tablet, capsule,Hard capsule, soft capsule, oral liquid, granule, honey pill agent, powder, sublimed preparation, solution or emplastrum etc. Preferably,The formulation of described pharmaceutical preparation is tablet, capsule or granule, most preferably is capsule.
The present invention is inventor through research repeatedly, progressively improves, the last good pharmaceutical preparation of successful a kind of curative effect, and logicalCross clinical case and further verified the curative effect of pharmaceutical preparation of the present invention, particulars are as described below:
1 data and method
1.1 physical data: observe year December in January, 2014 to 2014 and go to a doctor in my institute's Out-patient Clinic of Department of Gynecology, oral fugitive contraceptive causes the moonThrough very few patient 128 examples, be divided into observation group at random and control group is observed, every group of 64 examples. The age 23-35 of observation group year,28.1 ± 4.8 years old mean age, control group age 23-36 year, average 27.9 ± 4.6 years old; Observation group's course of disease is the longest 4.5 years, the shortest by 6Individual month, average 1.55 ± 1.08 years, the control group course of disease was the longest 4.5 years, the shortest 5 months, and average 1.46 ± 1.01 years, two groups generalData is no difference of science of statistics (P > 0.05) relatively, has comparativity.
1.2 diagnostic criteria: write the promulgation in 2002 of " Gynecology of Chinese Medicine " and Ministry of Health of the People's Republic of China according to Zhang Yuzhen etc.The diagnostic criteria of hypomenorrhia of the guideline of clinical investigations of irregular menstruation " new Chinese medicine treatment ".
Hypomenorrhia: hypomenorrhia refers to that the menstrual cycle is normal, and menstrual blood loss obviously reduces compared with constant, even drop is clean,Or through line time less than 2 days, through also few menopathy of amount.
1.3 inclusive criterias: (1) uses the women of oral fugitive contraceptive for 20～40 years old; (2) meet following cardinal symptom:Tcm diagnosis kidney-yin deficiency type hypomenorrhia: after taking contraceptive, MBV is gradually few, and look light is dim or dim red, or has clot; Companion seesSoreness and weakness of waist and knees, dysphoria in chestpalms-soles, hectically flushed cheeks, or insomnia and dreamful sleep; The red tongue of tongue is few, thready rapid pulse. (3) with just practising contraception front menstruationOften; (4) without contraindication person.
1.4 exclusion standards: prepare in the recent period pregnant women; Infrequent menstruation or be less than 20 years old, is greater than 40 years old person; Blood diseaseOr thrombotic diseases, endocrine system disease are as diabetes, hyperthyroidism; Pelvic cavity organic disease is as fibroid, sonEndometrial carcinoma etc.; Stein-Leventhal syndrome, premature ovarian failure, hyperprolactinemia, tuberculosis of endometrium, hypoplasia of uterusThe hypomenorrhia causing; Placement of intrauterine devices, takes long acting contraceptive, and skin buries hypomenorrhia person due to contraception.
1.5 methods of treatments:
Observation group: the capsule that menstruation brings into use the embodiment of the present invention 1 to prepare on the 5th day, every day twice, each 2-4 grain,When menstrual onset, withdraw, taking 3 months as one course for the treatment of, take continuously 3 months.
Control group: menstruation within the 5th day, give Climen compound preparation oral medication (first 11 all contain 2mg Estradiol Valerate,Latter 10 all contain 1mg cyproterone acetate and 2mg Estradiol Valerate, and 1 time/d, 1 piece/times, take continuously 3 weeks,After drug withdrawal, within the 5th day, carry out repeat administration in menstruation again, continue 3 menstrual period.
1.6 observation index:
1.6.1 ultrasound observation method LOGIQ-3 type color ultrasonic diagnosis instrument; IC5-9-D type end is swept the protruding battle array of formula vaginal ultrasonic probe, inspectionLook into the 14-16 days of time menstruation; Adopt Salle scoring: Salle scoring full marks are 20 points, and scoring content comprises uterusInner film thickness and form, mesometrium echo, Uterus artery pulse index (PI), Endometrial blood flow, incisura before diastoleAnd diastole end of term blood flow. Wherein, >=3 blood vessels pass through and hold the outer field low echo zone of endometrium, enter endometriumLayer, judges that endometrium exists blood flow.
1.6.2 observe change--MBV look, the matter of two groups for the treatment of front and back menstruations, pass through the time, menstrual cycle, judgementResult for the treatment of.
1.6.3 the observation of adverse drug reaction during medication: have or not and occur bad reaction record during observation medication, as stomach and intestineRoad discomfort, allergic reaction, colporrhagia time lengthening etc. As the person that occurs serious adverse reaction, discontinue medication immediately, exitThis research.
1.7 criterions of therapeutical effect: according to " guideline of clinical investigations of new Chinese medicine treatment irregular menstruation ", draft following curative effect markAccurate: recovery from illness: after treatment, MBV recovers normal, and 3 menstrual cycles of drug withdrawal do not recur; Effective: after treatment, MBV has brightAobvious increasing, menostaxis, and 3 menstrual cycles of drug withdrawal recur again; Effective: after treatment, MBV has certain increase, and menstrual period slightlyThere is prolongation; Invalid: after treatment, MBV is without improvement.
1.8 statistical methods: adopt SPSS15.0 statistical software to calculate. Each numerical value withRepresent measurement dataAdopt t inspection, enumeration data adopts χ2Inspection, has statistical significance taking P < 0.05 as difference.
2 results
The comparison of 2.1 liang of group patient curative effects: observation group's 22 examples of fully recovering, effective 27 examples, effective 14 examples, invalid 1 example, effectiveRate 76.56%, total effective rate 98.44%; Control group 9 examples of fully recovering, effective 18 examples, effective 23 examples, invalid 14 examples, aobviousEfficiency 42.19%, total effective rate 78.13%, observation group and control group obvious effective rate, total effective rate comparison, difference has statistics meaningJustice (P < 0.05), illustrates that observation group can significantly improve clinical cure rate and the obvious effective rate of hypomenorrhia compared with control group. In Table1。
Table 1 liang group patient's curative effect comparison (n%, example)
Note: with control group comparison, * P < 0.05.
Before and after 2.2 liang of group treatments, inner membrance changes relatively: treat front two groups of endometrium thickness, shalle scoring is relatively without systemMeter is learned difference (P > 0.05), after treatment, and two groups of endometrium thickness, shalle scoring all obviously raises before treatment, differenceHave notable statistics difference (P < 0.01), after treatment, between two groups, compare, difference has statistical significance (P < 0.05), observesThe result for the treatment of of group is obviously better than control group. In table 2.
Before and after table 2 liang group treatment, inner membrance changes relatively
Note: relatively front with treatment, * P < 0.05, * * P < 0.05; With control group comparison after treatment,#P＜0.05。
The observation of adverse drug reaction during 2.3 medications: have 1 routine patient to occur that slight intestines and stomach are anti-during the patient of observation group medicationShould. During control group patient medication, there are 18 routine patients to occur slight gastrointestinal reaction, as nauseating, vomiting, upper abdomen secret anguish; HaveThere is irregular colporrhagia in 3 routine patients, observation group and control group comparison, and difference has statistical significance, observation group's bad reactionStill less, patient compliance is better.
Treatment results shows: in this research, the patient's of observation group who treats with medicine of the present invention curative effect is obviously better than control group, controlsAfter treating, endometrium thickness obviously thickens before treating, and Salle scoring obviously improves before treatment, is also obviously better than control group, thereforeThan Climen, it is better that medicinal application of the present invention causes MBV clinical efficacy on the low side in contraceptive, the feelings that patient's menstruation is on the low sideCondition has clear improvement, and curative effect is worth certainly, in clinical treatment, should being applied.
We infer, pharmaceutical preparation of the present invention has many target spots, too many levels, multi-level comprehensive regulation effect, may be to improveThe blood flow of endometrial helicine artery, improves endometrial blood perfusion, promote microcirculation, endometrial growth,Repair; Also may improve endometrial female, progesterone receptor content, many factors same-action improves menstruation, is a kind of peaceComplete effectively pharmaceutical preparation, for Chinese medicine hypomenorrhia provides new method, is worth further studying and applying.
Detailed description of the invention
Further describe the present invention by specific embodiment below, the present invention is not limited only to following examples. At model of the present inventionEnclose interior or not departing from content of the present invention, spirit and scope, change, combination or replacement that the present invention is carried out, forThose skilled in the art is apparent, and is included within the scope of the present invention.
Embodiment 1 capsule
Prescription: 20 parts of prepared rhizomes of rehmannia, 10 parts of Morinda officinalis, 12 parts of the seed of Chinese dodders, 18 parts of the fruits of Chinese wolfberry, 20 parts of the fruit of glossy privets, 8 parts of teasel roots, pelletJoin 12 parts, 10 parts of whorlleaf litse roots, 9 parts of Ligusticum wallichiis, 25 parts of evergreen mucuna root and leafs, 12 parts of rhizoma cyperis, 15 parts of sivery aleuritopteris herbs, mountain on the other way round disappear 15 parts, the root of bidentate achyranthes 66 parts, part, Radix Glycyrrhizae.
Preparation method: by described prepared rhizome of rehmannia, Morinda officinalis, the seed of Chinese dodder, the fruit of Chinese wolfberry, the fruit of glossy privet, teasel root, the red sage root, whorlleaf litse root,Ligusticum wallichii, evergreen mucuna root and leaf, rhizoma cyperi, sivery aleuritopteris herb, mountain on the other way round disappear, the root of bidentate achyranthes, Radix Glycyrrhizae mix in prescription ratio, add with respect to compounding substancesMeasure the water of 4～10 times, decoct 2～3 hours, filter and obtain the first extract; Filtering the dregs of a decoction that obtain adds with respect to the described dregs of a decoction againThe water that quality is 2～4 times, decocts 1～2 hour, filters and obtains the second extract; The first extract and the second extract are merged, subtractPress and concentrate, dry, obtain and get dry extract, cream is placed in micronizer and is pulverized 1～2 hour, pulverize, sieve, obtain 100-200Object fine powder, prepares according to pharmaceutical preparation common process.
Every 0.35g of the present embodiment Chinese medicinal capsule, contains crude drug 2.0g.
Embodiment 2 capsules
Prescription: 18 parts of prepared rhizomes of rehmannia, 10 parts of Morinda officinalis, 15 parts of the seed of Chinese dodders, 15 parts of the fruits of Chinese wolfberry, 20 parts of the fruit of glossy privets, 6 parts of teasel roots, pelletJoin 10 parts, 12 parts of whorlleaf litse roots, 7 parts of Ligusticum wallichiis, 25 parts of evergreen mucuna root and leafs, 10 parts of rhizoma cyperis, 15 parts of sivery aleuritopteris herbs, mountain on the other way round disappear 10 parts, the root of bidentate achyranthes 46 parts, part, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 3 capsules
Prescription: 18 parts of prepared rhizomes of rehmannia, 15 parts of Morinda officinalis, 10 parts of the seed of Chinese dodders, 20 parts of the fruits of Chinese wolfberry, 15 parts of the fruit of glossy privets, 5 parts of teasel roots, pelletJoin 10 parts, 15 parts of whorlleaf litse roots, 6 parts of Ligusticum wallichiis, 30 parts of evergreen mucuna root and leafs, 15 parts of rhizoma cyperis, 15 parts of sivery aleuritopteris herbs, mountain on the other way round disappear 10 parts, the root of bidentate achyranthes 56 parts, part, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 4 capsules
Prescription: 22 parts of prepared rhizomes of rehmannia, 12 parts of Morinda officinalis, 15 parts of the seed of Chinese dodders, 15 parts of the fruits of Chinese wolfberry, 25 parts of the fruit of glossy privets, 7 parts of teasel roots, pelletJoin 15 parts, 15 parts of whorlleaf litse roots, 8 parts of Ligusticum wallichiis, 22 parts of evergreen mucuna root and leafs, 10 parts of rhizoma cyperis, 18 parts of sivery aleuritopteris herbs, mountain on the other way round disappear 15 parts, the root of bidentate achyranthes 68 parts, part, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 5 capsules
Prescription: 24 parts of prepared rhizomes of rehmannia, 12 parts of Morinda officinalis, 15 parts of the seed of Chinese dodders, 18 parts of the fruits of Chinese wolfberry, 25 parts of the fruit of glossy privets, 5 parts of teasel roots, pelletJoin 10 parts, 18 parts of whorlleaf litse roots, 12 parts of Ligusticum wallichiis, 30 parts of evergreen mucuna root and leafs, 10 parts of rhizoma cyperis, 16 parts of sivery aleuritopteris herbs, mountain on the other way round disappear 12 parts, the root of bidentate achyranthes 37 parts, part, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 6 capsules
Prescription: 13 parts of prepared rhizomes of rehmannia, 8 parts of Morinda officinalis, 10 parts of the seed of Chinese dodders, 15 parts of the fruits of Chinese wolfberry, 20 parts of the fruit of glossy privets, 5 parts of teasel roots, pelletJoin 8 parts, 15 parts of whorlleaf litse roots, 8 parts of Ligusticum wallichiis, 20 parts of evergreen mucuna root and leafs, 10 parts of rhizoma cyperis, 15 parts of sivery aleuritopteris herbs, mountain on the other way round disappear 12 parts, the root of bidentate achyranthes 58 parts, part, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 7 capsules
Prescription: 20 parts of prepared rhizomes of rehmannia, 15 parts of Morinda officinalis, 12 parts of the seed of Chinese dodders, 18 parts of the fruits of Chinese wolfberry, 23 parts of the fruit of glossy privets, 6 parts of teasel roots, pelletJoin 10 parts, 12 parts of whorlleaf litse roots, 9 parts of Ligusticum wallichiis, 25 parts of evergreen mucuna root and leafs, 15 parts of rhizoma cyperis, 18 parts of sivery aleuritopteris herbs, mountain on the other way round disappear 15 parts, the root of bidentate achyranthes 66 parts, part, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 8 capsules
Prescription: 25 parts of prepared rhizomes of rehmannia, 15 parts of Morinda officinalis, 10 parts of the seed of Chinese dodders, 25 parts of the fruits of Chinese wolfberry, 20 parts of the fruit of glossy privets, 6 parts of teasel roots, pelletJoin 16 parts, 13 parts of whorlleaf litse roots, 8 parts of Ligusticum wallichiis, 28 parts of evergreen mucuna root and leafs, 15 parts of rhizoma cyperis, 19 parts of sivery aleuritopteris herbs, mountain on the other way round disappear 16 parts, the root of bidentate achyranthes 68 parts, part, Radix Glycyrrhizae.
Preparation method: with reference to embodiment 1.
Embodiment 9 tablets
Prescription: 20 parts of prepared rhizomes of rehmannia, 10 parts of Morinda officinalis, 12 parts of the seed of Chinese dodders, 18 parts of the fruits of Chinese wolfberry, 20 parts of the fruit of glossy privets, 8 parts of teasel roots, pelletJoin 12 parts, 10 parts of whorlleaf litse roots, 9 parts of Ligusticum wallichiis, 25 parts of evergreen mucuna root and leafs, 12 parts of rhizoma cyperis, 15 parts of sivery aleuritopteris herbs, mountain on the other way round disappear 15 parts, the root of bidentate achyranthes 66 parts, part, Radix Glycyrrhizae.
Preparation method: by described prepared rhizome of rehmannia, Morinda officinalis, the seed of Chinese dodder, the fruit of Chinese wolfberry, the fruit of glossy privet, teasel root, the red sage root, whorlleaf litse root,Ligusticum wallichii, evergreen mucuna root and leaf, rhizoma cyperi, sivery aleuritopteris herb, mountain on the other way round disappear, the root of bidentate achyranthes, Radix Glycyrrhizae mix in prescription ratio, add with respect to compounding substancesMeasure the water of 4～10 times, decoct 2～3 hours, filter and obtain the first extract; Filtering the dregs of a decoction that obtain adds with respect to the described dregs of a decoction againThe water that quality is 2～4 times, decocts 1～2 hour, filters and obtains the second extract; The first extract and the second extract are merged, subtractPress and concentrate, dry, obtain and get dry extract, cream is placed in micronizer and is pulverized 1～2 hour, pulverize, sieve, obtain 100-200Object fine powder, prepares according to pharmaceutical preparation common process.
Embodiment 10 granules
Prescription: 20 parts of prepared rhizomes of rehmannia, 10 parts of Morinda officinalis, 12 parts of the seed of Chinese dodders, 18 parts of the fruits of Chinese wolfberry, 20 parts of the fruit of glossy privets, 8 parts of teasel roots, pelletJoin 12 parts, 10 parts of whorlleaf litse roots, 9 parts of Ligusticum wallichiis, 25 parts of evergreen mucuna root and leafs, 12 parts of rhizoma cyperis, 15 parts of sivery aleuritopteris herbs, mountain on the other way round disappear 15 parts, the root of bidentate achyranthes 66 parts, part, Radix Glycyrrhizae.
Preparation method: by described prepared rhizome of rehmannia, Morinda officinalis, the seed of Chinese dodder, the fruit of Chinese wolfberry, the fruit of glossy privet, teasel root, the red sage root, whorlleaf litse root,Ligusticum wallichii, evergreen mucuna root and leaf, rhizoma cyperi, sivery aleuritopteris herb, mountain on the other way round disappear, the root of bidentate achyranthes, Radix Glycyrrhizae mix in prescription ratio, add with respect to compounding substancesMeasure the water of 4～10 times, decoct 2～3 hours, filter and obtain the first extract; Filtering the dregs of a decoction that obtain adds with respect to the described dregs of a decoction againThe water that quality is 2～4 times, decocts 1～2 hour, filters and obtains the second extract; The first extract and the second extract are merged, subtractPress and concentrate, dry, obtain and get dry extract, cream is placed in micronizer and is pulverized 1～2 hour, pulverize, sieve, obtain 100-200Object fine powder, prepares according to pharmaceutical preparation common process.
Claims (10)
1. treat contraceptive and cause the pharmaceutical preparation of hypomenorrhia, it is characterized in that by prepared rhizome of rehmannia, Morinda officinalis, the seed of Chinese dodder, Chinese hollyMatrimony vine, the fruit of glossy privet, teasel root, the red sage root, whorlleaf litse root, Ligusticum wallichii, evergreen mucuna root and leaf, rhizoma cyperi, sivery aleuritopteris herb, mountain on the other way round disappear, the root of bidentate achyranthes, Radix GlycyrrhizaeFor medicinal raw material is made,
The weight portion proportioning of each medicinal raw material is as follows: prepared rhizome of rehmannia 13-26 part, Morinda officinalis 8-18 part, seed of Chinese dodder 5-20 part, the fruit of Chinese wolfberry15-25 part, fruit of glossy privet 15-25 part, teasel root 5-10 part, red sage root 6-16 part, whorlleaf litse root 10-20 part, Ligusticum wallichii 5-15 part, evergreen mucuna root and leaf 16-32Part, rhizoma cyperi 8-18 part, sivery aleuritopteris herb 9-19 part, mountain on the other way round disappear 9-19 part, root of bidentate achyranthes 3-8 part, Radix Glycyrrhizae 3-8 part.
2. pharmaceutical preparation as claimed in claim 1, is characterized in that being made up of the medicinal raw material of following weight portion proportioning:
Prepared rhizome of rehmannia 18-24 part, Morinda officinalis 8-13 part, seed of Chinese dodder 10-15 part, fruit of Chinese wolfberry 15-20 part, fruit of glossy privet 18-23 part, teasel root6-9 part, red sage root 8-13 part, whorlleaf litse root 10-15 part, Ligusticum wallichii 7-12 part, evergreen mucuna root and leaf 22-28 part, rhizoma cyperi 9-15 part, sivery aleuritopteris herb 13-18Part, mountain on the other way round disappear 10-15 part, root of bidentate achyranthes 4-7 part, Radix Glycyrrhizae 3-8 part.
3. pharmaceutical preparation as claimed in claim 2, is characterized in that being made up of the medicinal raw material of following weight portion proportioning:
20 parts of prepared rhizomes of rehmannia, 10 parts of Morinda officinalis, 12 parts of the seed of Chinese dodders, 18 parts of the fruits of Chinese wolfberry, 20 parts of the fruit of glossy privets, 8 parts of teasel roots, the red sage root 12Part, 10 parts of whorlleaf litse roots, 9 parts of Ligusticum wallichiis, 25 parts of evergreen mucuna root and leafs, 12 parts of rhizoma cyperis, 15 parts of sivery aleuritopteris herbs, mountain on the other way round disappear 15 parts, 6 parts of the roots of bidentate achyranthes,6 parts, Radix Glycyrrhizae.
4. the pharmaceutical preparation as described in claim 1-3, it is characterized in that preparation method comprise the steps: by described prepared rhizome of rehmannia,Morinda officinalis, the seed of Chinese dodder, the fruit of Chinese wolfberry, the fruit of glossy privet, teasel root, the red sage root, whorlleaf litse root, Ligusticum wallichii, evergreen mucuna root and leaf, rhizoma cyperi, sivery aleuritopteris herb,Mountain on the other way round disappears, the root of bidentate achyranthes, Radix Glycyrrhizae mix in prescription ratio, adds the water with respect to 4～10 times of mixture qualities, decocts mistake 2～3 hoursFilter obtains the first extract; Filter the dregs of a decoction that obtain and add again the water with respect to 2～4 times of described dregs of a decoction quality, decoct 1～2 hour,Filter and obtain the second extract; The first extract and the second extract are merged, reduced pressure concentration, dry, obtain and get dry extract, by creamBe placed in micronizer and pulverize 1～2 hour, pulverize, sieve, obtain 100-200 object fine powder, add pharmaceutically acceptableAuxiliary material or complementary composition prepare according to pharmaceutical preparation common process.
5. the pharmaceutical preparation as described in as arbitrary in claim 1-3, the formulation that it is characterized in that described pharmaceutical preparation is peroral dosage form.
6. pharmaceutical preparation as claimed in claim 5, is characterized in that described peroral dosage form is tablet, film coated tablet, enteric coatingTablet, capsule, hard capsule, soft capsule, oral liquid, granule, honey pill agent, powder, sublimed preparation, solution or hardPaste etc.
7. pharmaceutical preparation as claimed in claim 6, is characterized in that described peroral dosage form is preferably tablet, capsule or particleAgent.
8. pharmaceutical preparation as claimed in claim 7, is characterized in that described peroral dosage form is preferably capsule.
9. the arbitrary described pharmaceutical preparation of claim 1-3 causes the purposes in the medicine of hypomenorrhia at preparation treatment contraceptive.
10. the purposes of the arbitrary described pharmaceutical preparation of claim 1-3 in the medicine of preparation treatment hypomenorrhia.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085317A (en) * | 2007-06-26 | 2007-12-12 | 北京艺信堂医药研究所 | Chinese patent medicine for treating hypomenorrhea |
| CN104524480A (en) * | 2015-01-29 | 2015-04-22 | 季新玲 | Traditional Chinese medicinal preparation for treating damp-heat accumulation type dysmenorrhea and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101085317A (en) * | 2007-06-26 | 2007-12-12 | 北京艺信堂医药研究所 | Chinese patent medicine for treating hypomenorrhea |
| CN104524480A (en) * | 2015-01-29 | 2015-04-22 | 季新玲 | Traditional Chinese medicinal preparation for treating damp-heat accumulation type dysmenorrhea and preparation method thereof |
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