CN104524480A - Traditional Chinese medicinal preparation for treating damp-heat accumulation type dysmenorrhea and preparation method thereof - Google Patents
Traditional Chinese medicinal preparation for treating damp-heat accumulation type dysmenorrhea and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicinal preparation for treating damp-heat accumulation type dysmenorrhea and a preparation method thereof and belongs to the field of traditional Chinese medicines. The traditional Chinese medicinal preparation for treating the damp-heat accumulation type dysmenorrhea is prepared from the following raw materials: curcuma aromatica, cortex phellodendri, Chinese angelica, bighead atractylodes rhizome, sophora flavescens, corydalis tuber, sargentgloryvine stem, semen plantaginis and hairyvein agrimony, has the effects of clearing heat and promoting diuresis, regulating qi and dispersing stagnation as well as promoting blood circulation and stopping pain, is high in curative ratio and total effective rate when being used for treating the damp-heat accumulation type dysmenorrhea and can treat both symptoms and root causes at the same time; besides, the traditional Chinese medicinal preparation for treating the damp-heat accumulation type dysmenorrhea can be prepared into multiple dosage forms, thereby being beneficial to clinical selection and application.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind ofly treat Chinese medicine preparation of damp-heat accumulation type dysmenorrhea and preparation method thereof.
Background technology
Allly be expert at through front and back or menstrual phase, periodically occur hypogastralgia, falling inflation, companion's soreness of waist or other are uncomfortable, or pain draws the waist bones of the body, even severe pain is fainted, and degree is heavier so that affect live and work quality person and be called dysmenorrhea, also known as abdominal pain during menstruation.Primary dysmenorrhea, mostly occur 2-3 after menophania or menophania.According to statistics, what primary dysmenorrhea occurred in First Year after menophania accounts for 75%, and in Second Year, incidence rate accounts for 13%, and in the 3rd year, incidence rate is 5%.Be more common in unmarried and do not educate women (13 ~ 25 years old), accounting for more than 90% of dysmenorrhea number, often after fertility, dysmenorrhea is alleviated or is disappeared, and dysmenorrhea one is sick, though non-difficult serious disease, is commonly encountered diseases, and patient is also rather worried.
Modern medicine is thought, uterine hypoplasia, uterus are bent excessively afterwards, pelvic inflammatory disease, endometriosis, endocrine disturbance, Prostaglandin increases in blood, all can cause dysmenorrhea.Doctor trained in Western medicine adopts PGSI to reduce the release of prostaglandin to the treatment of primary disease; Or use gonadal hormone ovulation inhibition, relief of symptoms; Or with the pain relieving of spasmolysis and analgesia medicine.Western medicine therapy mostly is relief of symptoms, and existence is cured the symptoms, not the disease, and through the drawback of row recurrence, and side effect is obvious, and clinical practice is very limited.
Chinese traditional treatment then takes Coryza Treated by Syndrome Differentiation to be main, with menstrual onset periodically lower abdomen panic attacks be dialectical main points, comprehensively analyze through amount, color, matter and arteries and veins disease according to the character of pain, degree, position referring and synthesizing.The concrete rule for the treatment of disappears it for cold person's using warming therapy, heat syndrome should be treated with clearing away heat therapy, treatment of deficiency-syndrome by reinforcement, real person, all helps with pain relieving among all methods, and this is giving consideration to both the incidental and fundamental and to effect a permanent cure as main principle.
Damp-heat accumulation type dysmenorrhea disease is seen: premenstrual or menstrual period lower abdomen causalgia tenderness, pain connects waist sacrum, or lower abdominal pain at ordinary times, the pain increased to premenstrual, and through measuring many or menstrual period are long, purple coloured menses is red, matter is thick or have clot, profuse leukorrhea usually, yellow thick smelly dirty, or companion's low grade fever; yellowish or reddish urine; red tongue, yellow and greasy fur, slippery and rapid pulse or moisten number.
Chinese traditional treatment primary disease shows unique characteristics, and can reach the object for the treatment of, can avoid again the toxic and side effects of Western medicine.Recent study result shows, Chinese medicine, while treatment dysmenorrhea pain, can also improve hemorheology index, points out its symptom in dysmenorrhea to improve and has significant advantage in late result.
Summary of the invention
Inventor is according to the clinical experience for the treatment of dysmenorrhea for many years, and clear and definite " wetting ", " heat ", " stasis of blood " are that the pathogenesis of this type dysmenorrhea is crucial, and damp and hot accumulateing holds back uterus, blood-vessel obstructive, stagnation of QI and blood may bring about pain, and damp and hot is this, and blood stasis is mark.Inventor provide a kind of Chinese medicine preparation for the treatment of damp-heat accumulation type dysmenorrhea based on this, it is based on clearing away heat-damp and promoting diuresis, and outstanding determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs spirit, helps with blood-activating analgetic, treating both the principal and secondary aspects of a disease.
For achieving the above object, the present invention adopts following technical scheme:
A kind of Chinese medicine preparation for the treatment of damp-heat accumulation type dysmenorrhea, it is characterized in that it is made up of following medicinal raw material: Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae, the weight portion of described each raw material is as follows: Radix Curcumae 15-22 part, Cortex Phellodendri 7-13 part, Radix Angelicae Sinensis 11-16 part, Rhizoma Atractylodis Macrocephalae 9-16 part, Radix Sophorae Flavescentis 18-25 part, Rhizoma Corydalis 8-16 part, Caulis Sargentodoxae 15-21 part, Semen Plantaginis 12-17 part, Herba Agrimoniae 15-20 part.
Fang Zhong: Radix Sophorae Flavescentis heat clearing and damp drying, Caulis Sargentodoxae heat-clearing and toxic substances removing, Cortex Phellodendri is apt to clear damp-heat in lower-JIAO, three medicines 5 with heat clearing away, expel the heat-evil, dampness power is strong, is monarch drug.Radix Curcumae cold in nature enter conscience warp, regulating qi to disperse stagnation, clear away heart-fire removing heat from blood, and warm in nature the enriching blood of Radix Angelicae Sinensis is invigorated blood circulation, regulating menstruation, and two medicine compatibility Wen Han develop simultaneously, and regulating qi to disperse stagnation, enriches blood and invigorate blood circulation, and is ministerial drug.Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, Semen Plantaginis clearing away heat and promoting diuresis, assistant monarch drug diuretic dampness, Rhizoma Corydalis is invigorated blood circulation, promoting the circulation of QI, pain relieving, assistant ministerial drug blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, Herba Agrimoniae detoxifies, and hemostasis, tool is that assistant makes.Full side has effect of clearing away heat-damp and promoting diuresis, regulating qi to disperse stagnation, promoting blood circulation and stopping pain combined into it, and so so damp and hot that to let out, QI and blood passes unimpeded, and all diseases disappear.
Preferably, the Chinese medicine preparation for the treatment of damp-heat accumulation type dysmenorrhea described above, is characterized in that the weight portion of described each raw material is as follows: Radix Curcumae 18-20 part, Cortex Phellodendri 9-11 part, Radix Angelicae Sinensis 12-15 part, Rhizoma Atractylodis Macrocephalae 12-15 part, Radix Sophorae Flavescentis 20-23 part, Rhizoma Corydalis 13-15 part, Caulis Sargentodoxae 18-20 part, Semen Plantaginis 14-17 part, Herba Agrimoniae 18-20 part.
Further preferably, the Chinese medicine preparation for the treatment of damp-heat accumulation type dysmenorrhea described above, is characterized in that the weight portion of described each raw material is as follows: Radix Curcumae 19 parts, Cortex Phellodendri 10 parts, Radix Angelicae Sinensis 13 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Sophorae Flavescentis 22 parts, Rhizoma Corydalis 14 parts, Caulis Sargentodoxae 19 parts, Semen Plantaginis 15 parts, Herba Agrimoniae 19 parts.
Present Research and the pharmacological activity of the present invention's each medicinal raw material used are as described below:
Radix Curcumae: pungent, bitter, cold.Return liver, the heart, lung meridian.Function cures mainly: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Cortex Phellodendri: bitter, cold.Return kidney, urinary bladder channel.Function cures mainly: heat clearing and damp drying, and pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Sophorae Flavescentis: bitter, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel.Function cures mainly: heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.
Rhizoma Corydalis: pungent, bitter, temperature.Return liver, spleen channel.Function cures mainly: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Caulis Sargentodoxae: bitter, flat.Return large intestine, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, invigorates blood circulation, and dispels the wind.For abdominalgia with intestinal abscess, amenorrhea dysmenorrhea, rheumatic arthralgia, tumbling and swelling.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Semen Plantaginis: sweet, is slightly cold.Return liver, kidney, lung, small intestine meridian.Function cures mainly: clearing away heat and promoting diuresis, and eliminating dampness by diuresis is treating stranguria, and improving eyesight is eliminated the phlegm.For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.
Herba Agrimoniae: bitter, puckery is flat.GUIXIN, Liver Channel.Function cures mainly: astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia.
Present invention also offers the preparation method of this medicine Chinese medicine preparation, it comprises the steps: described Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae to mix in prescription ratio, add the water relative to mixture quality 4 ~ 6 times, decoct 2 ~ 3 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 2 ~ 4 times again, decoct 1 ~ 2 hour, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure, dry, obtain and get dry extract, cream is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, acquisition 100-200 object fine powder, adds pharmaceutically acceptable adjuvant or complementary composition prepares according to Chinese medicine preparation common process.
Described pharmaceutically acceptable carrier or complementary composition, as starch, Icing Sugar, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, fructose, carboxymethyl starch sodium, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc.
The dosage form of described Chinese medicine preparation is tablet, capsule, pill, granule, oral liquid, soft capsule, dispersible tablet, powder etc.
Preferably, the dosage form of described Chinese medicine preparation is tablet, capsule or granule.
The present invention is that inventor is through repeatedly studying, progressively improve a kind of curative effect of waiting until treats the medicine of damp-heat accumulation type dysmenorrhea preferably, can verify the therapeutic effect of Chinese medicine preparation of the present invention to damp-heat accumulation type dysmenorrhea by 100 routine clinical cases, particulars is as described below:
1. physical data: select damp-heat accumulation type dysmenorrhea patient 100 example of going to a doctor in March, 9 ~ 2014 in 2013 in my institute, be divided into treatment group and matched group at random, each 50 examples.16 ~ 37 years old treatment group age, the mean age (26.6 ± 6.7) year, the course of disease 1 ~ 8 year, average (4.8 ± 1.6) year; 17 ~ 38 years old matched group age, average (27.1 ± 7.3) year, the course of disease 1 ~ 9 year, average (5.2 ± 1.8) year.Two groups of physical data, through statistical procedures difference nonsignificance (P > 0.05), have comparability.
2. diagnostic criteria: Western medicine diagnose is according to " newly organized practical gynecology ": menstrual period or lower abdomen pain before and after row, pain and waist sacrum, very then faint, in periodical attack; Tcm diagnosis is according to " new Chinese medicine guideline of clinical investigations " (1993, China Medical Science Press), and disease is seen: premenstrual or menstrual period lower abdomen causalgia tenderness, pain connects waist sacrum, or lower abdominal pain at ordinary times, and the pain increased to premenstrual, through measuring many or menstrual period are long, purple coloured menses is red, and matter is thick or have clot, profuse leukorrhea usually, yellow thick smelly dirty, or companion's low grade fever; yellowish or reddish urine; red tongue, yellow and greasy fur, slippery and rapid pulse or moisten number.
3. exclusion standard: have significant organic pathological changes person through gynecologial examination; Those who are allergic to this drug; Be associated with severe primary disease, the psychotics such as cardiovascular, liver, kidney and hemopoietic system; Menstrual cycle is irregular, and affect the treatment judgement person; Do not take medicine by regulation, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person.
4. Therapeutic Method
Treatment group: take capsule prepared by the embodiment of the present invention 1, each 2-3 grain, every 0.5g (being equivalent to crude drug 2.3g) 2 sub-service sooner or later, each menstrual cycle is when premenstrual 5 days or lower abdomen burning pain, start to take medicine, clothes are to second and third sky of menstruation, and 3 cycles for the treatment of were 1 course for the treatment of continuously.
Matched group: oral YUANHU ZHITONG PIAN, a 4-6 sheet, 3 times on the one.Each menstrual cycle, when premenstrual 5 days or lower abdomen burning pain, starts to take medicine, and takes to second and third sky of menstruation, and 3 cycles for the treatment of were 1 course for the treatment of continuously.
Two groups of patients all inform, note menstrual hygiene, note rule of life.
5. observation index: clinical symptoms, untoward reaction.
6. efficacy determination: treated for 1 course for the treatment of, judges curative effect.With reference to " Gynecology of Chinese Medicine " (Calculus Equi jade tablet, Shanghai science tech publishing house, 1999) customization.Recovery from illness: abdominal pain in menstruation and other transference cures after taking medicine, drug withdrawal 3 non-recidivists of menstrual cycle; Effective: stomachache obviously alleviates, all the other symptoms take a turn for the better, and drug withdrawal 3 menstrual cycle symptoms do not increase the weight of; Effective: stomachache alleviates, other symptoms take a turn for the better, though symptom repeatedly, comparatively alleviates before treatment after drug withdrawal; Invalid: stomachache and other symptoms are without change or add severe one.
7. result
Treatment group total effective rate is 96.0%, and matched group total effective rate is 640%, two groups of comparitive study difference significances (P<0.05), shows the excellent prior art of curative effect of Drug therapy damp-heat accumulation type dysmenorrhea of the present invention.In table 1.
Table 1 liang group Clinical efficacy comparison
| Group | Number | Cure | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 50 | 23(46％) | 15(30％) | 10(20％) | 2(4％) | 96％ |
| Matched group | 50 | 5(10％) | 14(28％) | 13(26％) | 18(36％) | 64％ |
Treatment group has no obvious adverse reaction; Matched group has two routine patients to occur stomachache, acid regurgitation situation, has 3 examples to occur mild diarrhea.
Visible, medicine of the present invention compared with prior art, have significant progressive, promote the use of by clinic.
In sum, beneficial effect of the present invention is:
1. Chinese medicine preparation of the present invention has effect of clearing away heat-damp and promoting diuresis, regulating qi to disperse stagnation, promoting blood circulation and stopping pain, for damp-heat accumulation type dysmenorrhea treating both the principal and secondary aspects of a disease.
2. Chinese medicine preparation cure rate of the present invention is high, and total effective rate is high.
3. the many kinds of selective uses of dosage form, convenient.
4. pure Chinese medicinal preparation, have no side effect.
Detailed description of the invention
The detailed description of the invention of form by the following examples, is described in further detail foregoing of the present invention again.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example.All technology realized based on foregoing of the present invention all belong to scope of the present invention.
The preparation of embodiment 1 capsule
Prescription: Radix Curcumae 19 parts, Cortex Phellodendri 10 parts, Radix Angelicae Sinensis 13 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Sophorae Flavescentis 22 parts, Rhizoma Corydalis 14 parts, Caulis Sargentodoxae 19 parts, Semen Plantaginis 15 parts, Herba Agrimoniae 19 parts.
Preparation method: by described Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae in the mixing of prescription ratio, add the water relative to mixture quality 5 times, decoct 2.5 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 3 times again, decoct 1.5 hours, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure, dry, obtain and get dry extract, cream is placed in super micron mill and pulverizes 1.5 hours, pulverize, sieve, obtain 180 object fine powders, add pharmaceutically acceptable adjuvant or complementary composition prepares according to Chinese medicine preparation common process.
The preparation of embodiment 2 capsule
Prescription: Radix Curcumae 18 parts, Cortex Phellodendri 9 parts, Radix Angelicae Sinensis 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Sophorae Flavescentis 20 parts, Rhizoma Corydalis 13 parts, Caulis Sargentodoxae 18 parts, Semen Plantaginis 14 parts, Herba Agrimoniae 18 parts.
Preparation method: by described Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae in the mixing of prescription ratio, add the water relative to mixture quality 4 times, decoct 2 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 4 times again, decoct 1 hour, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure, dry, obtain and get dry extract, cream is placed in super micron mill and pulverizes 1 hour, pulverize, sieve, obtain 100 object fine powders, add pharmaceutically acceptable adjuvant or complementary composition prepares according to Chinese medicine preparation common process.
The preparation of embodiment 3 capsule
Prescription: Radix Curcumae 20 parts, Cortex Phellodendri 11 parts, Radix Angelicae Sinensis 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Sophorae Flavescentis 23 parts, Rhizoma Corydalis 15 parts, Caulis Sargentodoxae 20 parts, Semen Plantaginis 17 parts, Herba Agrimoniae 20 parts.
Preparation method: by described Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae in the mixing of prescription ratio, add the water relative to mixture quality 6 times, decoct 2 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 2 times again, decoct 1 hour, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure, dry, obtain and get dry extract, cream is placed in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 200 object fine powders, add pharmaceutically acceptable adjuvant or complementary composition prepares according to Chinese medicine preparation common process.
The preparation of embodiment 4 capsule
Prescription: Radix Curcumae 18 parts, Cortex Phellodendri 11 parts, Radix Angelicae Sinensis 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Sophorae Flavescentis 23 parts, Rhizoma Corydalis 13 parts, Caulis Sargentodoxae 20 parts, Semen Plantaginis 16 parts, Herba Agrimoniae 18 parts.
Preparation method: by described Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae in the mixing of prescription ratio, add the water relative to mixture quality 4 times, decoct 2 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 3 times again, decoct 1.5 hours, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure, dry, obtain and get dry extract, cream is placed in super micron mill and pulverizes 1.5 hours, pulverize, sieve, obtain 180 object fine powders, add pharmaceutically acceptable adjuvant or complementary composition prepares according to Chinese medicine preparation common process.
The preparation of embodiment 5 tablet
Prescription: Radix Curcumae 15 parts, Cortex Phellodendri 7 parts, Radix Angelicae Sinensis 11 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Radix Sophorae Flavescentis 18 parts, Rhizoma Corydalis 8 parts, Caulis Sargentodoxae 15 parts, Semen Plantaginis 12 parts, Herba Agrimoniae 15 parts.
Preparation method: by described Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae in the mixing of prescription ratio, add the water relative to mixture quality 5 times, decoct 2.5 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 2 times again, decoct 1 hour, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure, dry, obtain and get dry extract, cream is placed in super micron mill and pulverizes 1 hour, pulverize, sieve, obtain 100 object fine powders, add pharmaceutically acceptable adjuvant or complementary composition prepares according to Chinese medicine preparation common process.
The preparation of embodiment 6 tablet
Prescription: Radix Curcumae 22 parts, Cortex Phellodendri 13 parts, Radix Angelicae Sinensis 16 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Radix Sophorae Flavescentis 25 parts, Rhizoma Corydalis 16 parts, Caulis Sargentodoxae 21 parts, Semen Plantaginis 17 parts, Herba Agrimoniae 20 parts.
Preparation method: by described Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae in the mixing of prescription ratio, add the water relative to mixture quality 6 times, decoct 3 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 4 times again, decoct 2 hours, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure, dry, obtain and get dry extract, cream is placed in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 200 object fine powders, add pharmaceutically acceptable adjuvant or complementary composition prepares according to Chinese medicine preparation common process.
The preparation of embodiment 7 granule
Prescription: Radix Curcumae 15 parts, Cortex Phellodendri 13 parts, Radix Angelicae Sinensis 14 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Sophorae Flavescentis 18 parts, Rhizoma Corydalis 15 parts, Caulis Sargentodoxae 21 parts, Semen Plantaginis 15 parts, Herba Agrimoniae 17 parts.
Preparation method: by described Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae in the mixing of prescription ratio, add the water relative to mixture quality 4 times, decoct 2 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 4 times again, decoct 1 hour, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure, dry, obtain and get dry extract, cream is placed in super micron mill and pulverizes 1.5 hours, pulverize, sieve, obtain 180 object fine powders, add pharmaceutically acceptable adjuvant or complementary composition prepares according to Chinese medicine preparation common process.
The preparation of embodiment 8 granule
Prescription: Radix Curcumae 19 parts, Cortex Phellodendri 11 parts, Radix Angelicae Sinensis 14 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Sophorae Flavescentis 23 parts, Rhizoma Corydalis 15 parts, Caulis Sargentodoxae 20 parts, Semen Plantaginis 14 parts, Herba Agrimoniae 18 parts.
Preparation method: by described Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae in the mixing of prescription ratio, add the water relative to mixture quality 5 times, decoct 2.5 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 3 times again, decoct 1.5 hours, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure, dry, obtain and get dry extract, cream is placed in super micron mill and pulverizes 1.5 hours, pulverize, sieve, obtain 160 object fine powders, add pharmaceutically acceptable adjuvant or complementary composition prepares according to Chinese medicine preparation common process.
The preparation of embodiment 9 pill
Prescription: Radix Curcumae 19 parts, Cortex Phellodendri 11 parts, Radix Angelicae Sinensis 15 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Radix Sophorae Flavescentis 20 parts, Rhizoma Corydalis 15 parts, Caulis Sargentodoxae 19 parts, Semen Plantaginis 16 parts, Herba Agrimoniae 19 parts.
Preparation method: by described Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae in the mixing of prescription ratio, add the water relative to mixture quality 5 times, decoct 2.5 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 4 times again, decoct 1.5 hours, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure, dry, obtain and get dry extract, cream is placed in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 200 object fine powders, add pharmaceutically acceptable adjuvant or complementary composition prepares according to Chinese medicine preparation common process.
The preparation of embodiment 10 oral liquid
Prescription: Radix Curcumae 18 parts, Cortex Phellodendri 11 parts, Radix Angelicae Sinensis 15 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Sophorae Flavescentis 22 parts, Rhizoma Corydalis 15 parts, Caulis Sargentodoxae 20 parts, Semen Plantaginis 14 parts, Herba Agrimoniae 19 parts.
Preparation method: by described Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae in the mixing of prescription ratio, add the water relative to mixture quality 5 times, decoct 2.5 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 3 times again, decoct 1.5 hours, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure, dry, obtain and get dry extract, cream is placed in super micron mill and pulverizes 1.5 hours, pulverize, sieve, obtain 160 object fine powders, add water and pharmaceutically acceptable adjuvant or complementary composition and prepare according to Chinese medicine preparation common process.
Claims (6)
1. treat the Chinese medicine preparation of damp-heat accumulation type dysmenorrhea for one kind, it is characterized in that it is made up of following medicinal raw material: Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae, the weight portion of described each raw material is as follows: Radix Curcumae 15-22 part, Cortex Phellodendri 7-13 part, Radix Angelicae Sinensis 11-16 part, Rhizoma Atractylodis Macrocephalae 9-16 part, Radix Sophorae Flavescentis 18-25 part, Rhizoma Corydalis 8-16 part, Caulis Sargentodoxae 15-21 part, Semen Plantaginis 12-17 part, Herba Agrimoniae 15-20 part.
2. Chinese medicine preparation as claimed in claim 1, its spy is really that the weight portion of described each raw material is as follows: Radix Curcumae 18-20 part, Cortex Phellodendri 9-11 part, Radix Angelicae Sinensis 12-15 part, Rhizoma Atractylodis Macrocephalae 12-15 part, Radix Sophorae Flavescentis 20-23 part, Rhizoma Corydalis 13-15 part, Caulis Sargentodoxae 18-20 part, Semen Plantaginis 14-17 part, Herba Agrimoniae 18-20 part.
3. Chinese medicine preparation as claimed in claim 2, is characterized in that the weight portion of described each raw material is as follows: Radix Curcumae 19 parts, Cortex Phellodendri 10 parts, Radix Angelicae Sinensis 13 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Sophorae Flavescentis 22 parts, Rhizoma Corydalis 14 parts, Caulis Sargentodoxae 19 parts, Semen Plantaginis 15 parts, Herba Agrimoniae 19 parts.
4. the Chinese medicine preparation as described in as arbitrary in claim 1-3, it is characterized in that its preparation method comprises the steps: described Radix Curcumae, Cortex Phellodendri, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Sophorae Flavescentis, Rhizoma Corydalis, Caulis Sargentodoxae, Semen Plantaginis, Herba Agrimoniae to mix in prescription ratio, add the water relative to mixture quality 4 ~ 6 times, decoct 2 ~ 3 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 2 ~ 4 times again, decoct 1 ~ 2 hour, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure, dry, obtain and get dry extract, cream is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, acquisition 100-200 object fine powder, adds pharmaceutically acceptable adjuvant or complementary composition prepares according to Chinese medicine preparation common process.
5. the Chinese medicine preparation as described in claim 1-4, is characterized in that the dosage form of described Chinese medicine preparation is tablet, capsule, pill, granule, oral liquid, soft capsule, dispersible tablet, powder etc.
6. Chinese medicine preparation as claimed in claim 5, is characterized in that the dosage form of described Chinese medicine preparation is preferably tablet, capsule or granule.
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| CN105596631A (en) * | 2016-01-11 | 2016-05-25 | 青岛辰达生物科技有限公司 | Pharmaceutical preparation for treating hypomenorrhea caused by contraceptives |
| CN106389662A (en) * | 2015-12-31 | 2017-02-15 | 定西华清园中医药工程研究开发中心 | Radix angelicae sinensis containing health care medicine for treating dysmenorrhea with syndrome of damp and heat accumulation |
| CN107343553A (en) * | 2017-09-14 | 2017-11-14 | 陇南市任华种植业开发有限公司 | A kind of processing method of Chinese prickly ash tender shoots health protection tea |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105148026A (en) * | 2015-10-16 | 2015-12-16 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicine composition for treating dysmenorrheal caused by damp-heat stagnation |
| CN106389662A (en) * | 2015-12-31 | 2017-02-15 | 定西华清园中医药工程研究开发中心 | Radix angelicae sinensis containing health care medicine for treating dysmenorrhea with syndrome of damp and heat accumulation |
| CN105596631A (en) * | 2016-01-11 | 2016-05-25 | 青岛辰达生物科技有限公司 | Pharmaceutical preparation for treating hypomenorrhea caused by contraceptives |
| CN107343553A (en) * | 2017-09-14 | 2017-11-14 | 陇南市任华种植业开发有限公司 | A kind of processing method of Chinese prickly ash tender shoots health protection tea |
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Application publication date: 20150422 |