CN102274472A - Traditional Chinese medicine patch for treating female dysmenorrhoea and preparation thereof - Google Patents
Traditional Chinese medicine patch for treating female dysmenorrhoea and preparation thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine patch for treating female dysmenorrhoea and a preparation thereof. The preparation comprises the following steps: powdering the traditional Chinese medicinal materials of cinnamon, rhizoma zingiberis, Chinese angelica, Ligusticum wallichii, red paeony root, peach seed, cyperus rotundus, trogopterus dung, crude cattail pollen, English walnut seed and amber according to certain proportions; in the treatment of menstrual period, taking 1-3 g of powder, immersing in the liquor with 60% content of alcohol, mixing uniformly, preparing into an ointment, applying the ointment in the navel with adhesive plasters externally for fixing, carrying out dressing change once in 24 h, applying the medicine continuously for 5-6 days and continuously 3 menstrual cycles as a course. Generally, patients receive the medicine cured in 1-2 courses without relapse. The medicine combines an acupoint differentiation theory, has the advantages of tonifying the spleen and kidney, warming and recuperating vital gate, clearing heat and draining dampness, promoting blood circulation and removing blood stasis, can be used for treating female dysmenorrhoea caused by cold and dampness and stasis syndrome, has definite therapeutic effect and high cure rate. The application of the medicine is convenient without taking drugs, injection or transfusion, without discomfort or pain, so that the medicine is very popular with patients.
Description
Technical field
The present invention relates to a kind of Chinese herbs paste and preparation for the treatment of menalgia, belong to the field of Chinese medicines.
Background technology
Dysmenorrhea (Dysmenorrhea) is meant that periodically lower abdomen pain appears in the women on the occasion of menstrual period or before and after passing through, or draws the waist sacrum bitterly, and very then severe pain faintness person is commonly encountered diseases, the frequently-occurring disease in the gynecological clinic, has a strong impact on work and quality of life.The traditional Chinese medical science thinks that the dysmenorrhoea disease position is main pathogenesis in the uterus, towards appointing with " stagnation of QI and blood may bring about pain " or " Rong Ze pain ".Treatment is based on QI and blood regulating, carries out the differentiation of symptoms and signs for classification of syndrome opinion and controls according to time of pain, character, position, degree and in conjunction with hold concurrently disease, tongue, arteries and veins of menstrual phase amount, color, matter.Dysmenorrhea is divided into two kinds of constitutional and Secondary cases again, and primary dysmenorrhea promptly begins to occur after mostly being maiden's menophania, or relevant with physical factors, or because of cold the catching cold of drink in menstrual period, among the cold objective born of the same parents, gas loses Wen Yun, stays in the blood stasis, cause vessels of the uterus and be obstructed, obstructed and the pain, account for more than 90% of dysmenorrhea.Secondary dysmenorrhea mostly is the child-bearing period gynecologic menstrual and catches cold, or puerperal is careless, and when wind catches cold, cold-damp visitor is in born of the same parents, or repeatedly artificial abortion's history arranged, impairment of the uterine collateral, the blood circulating out of vessels stasis of blood stagnate uterus, vessels of the uterus, stagnation of blood stasis, functional activity of QI being not smooth, the body fluid interruption of service, with the passing of time poly-and give birth to the wet expectorant of making, wet, expectorant, the stasis of blood form the disease of lump in the abdomen.
For the dysmenorrhea diagnosis and treatment, doctor trained in Western medicine clinically by B ultrasonic, X line so that primary dysmenorrhea and secondary dysmenorrhea are made a differential diagnosis, treatment is based on pain relieving, analgesia, spasmolytic, if suffer from salpingitis, oophoritis, parametritises etc. are used the antibiotic active treatment.The uterine hypoplasia person can treat by oral diethylstilbestrol, when pain is serious, can oral somedon, atropine, Indometacin,Aspirin and promethazine etc., the estrogen and progestogen clinical practice can suppress uterine contraction or suppress ovulation and pain relieving, but suppresses the ovary normal function because of it, so Ying Shenyong.
Chinese traditional treatment dysmenorrhea method is various, the clinical common methods such as acupuncture, massage, massage, magnetic therapy, dietetic therapy that have, and some Chinese patent medicines also can be treated dysmenorrhea, as " YUANHU ZHITONG PIAN " " tablet of ten ingredients for woman diseases ".Acupuncture, massage etc. are many with in conjunction with the acupuncture point determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, though obtain certain effect, because of acupoint selection in the operation accurately, execute the pin maneuver, the power of massage, maneuver etc. all can influence therapeutic effect, so be unfavorable for extensive use.The patent of the relevant in recent years treatment of retrieval dysmenorrhea, only the patent of invention of Gong Buing has nearly 260, and is wherein in the majority with Chinese medicine decoction, capsule and therapeutic equipments, external is deposited control less.Given this, the inventor sums up oneself year clinical position experience surplus 30, has invented double the executing of a kind of conditioning, warming and recuperating the spleen and kidney, and clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling are applicable to the Chinese herbs paste of the dysmenorrhes that cold-damp, the stasis of blood cause.
Summary of the invention
Purpose of the present invention be exactly at above-mentioned clinical in the problem that exists of existing treatment, and provide a kind of convenient effective Chinese medicine patch.Promptly from the pathomechanism of dysmenorrhea, choose the cave of wanting---the SHENQUE acupoint on the conception vessel, apply with plaster, can infiltrate fast in the body, be beneficial to absorption, improve body endogenous cold, stasis of blood situation, mediation spleen kidney makes QI and blood battalion and unobstructed.Effective Components of Chinese Herb is again the trace element of pure natural plants albumen, animal proteinum and mineral in addition, after entering human body, select its effective ingredient for body, and the metabolism of participation human body, nurse one's health the balance of viscera, QI and blood on the whole, immunologic function is improved, and it is normal that the physiological function of liver,spleen,kidney is recovered, and consolidates so can get rid of illness.Less because of Chinese herbal medicine again to the human body side effect, and can effect a permanent cure.For this reason, selecting the traditional Chinese medical herbal treatment dysmenorrhea, is effective selection.
The present invention nurses one's health double executing, warming and recuperating the spleen and kidney, and clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling are applicable to the dysmenorrhes that cold-damp, the stasis of blood cause, determined curative effect, the cure rate height, and easy to operate, do not take medicine, do not have an injection, not infuse, the no any discomfort and the pain of injury are accepted by the patient deeply.
The present invention selects Cortex Cinnamomi, Rhizoma Zingiberis Preparatum, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Semen Persicae, Rhizoma Cyperi, Oletum Trogopterori, Pollen Tyjphae, semen juglandis and 11 kinds of Chinese medicines of succinum to make up, the principle that counteracts each other according to Chinese medicine, make each efficacy of drugs produce synergism the effective combination of these medicines, thereby reach the effect of clearing away heat-damp and promoting diuresis, QI and blood regulating, impel spleen kidney battalion and degree of having.Cortex Cinnamomi extremely hot in nature wherein, acrid in the mouth, sweet is returned kidney, spleen, the heart, Liver Channel, and it is supporing yang to have a fire of benefit, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow function.Be used for sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.Rhizoma Zingiberis Preparatum bitter in the mouth, puckery, warm in nature, hot, hot, return spleen, stomach, kidney, the heart, lung meridian.Warming spleen and stomach for dispelling cold, warming the meridian for stopping bleeding.Be used for Deficiency and coldness of spleen and stomach, stomachache is vomited and diarrhoea, and tells the nosebleed metrorrhagia, and yang deficiency is lost blood.Radix Angelicae Sinensis is warm in nature, and sweet in the mouth, suffering are returned liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, the effect of menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.The Rhizoma Chuanxiong acrid in the mouth is warm in nature, returns liver, gallbladder, pericardium channel.Be used for pain in chest and hypochondrium, rheumatic arthralgia, lump in the abdomen caking, skin infection and swell and ache, fall diseases such as pouncing on the pain of injury, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain.Radix Paeoniae Rubra bitter in the mouth cold nature is returned Liver Channel, clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.Semen Persicae bitter in the mouth, sweet, property is flat, and GUIXIN, liver, large intestine channel have blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.Be used for amenorrhea, dysmenorrhea, mass in the abdomen mass in the abdomen, injury from falling down, dryness of the intestine constipation, Semen Persicae has the increase drug absorption.The hot little hardship of Rhizoma Cyperi is sweet, flat, goes into liver, tri-jiao channel, the resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.Oletum Trogopterori is sweet in flavor and warm in property, and is nontoxic, goes into Liver Channel, has the mediation blood vessels, and the effect of eliminating stasis to stop pain cures mainly stasis, amenorrhea, stomachache, diseases such as the breast side of body twinge, tumbling and swelling and snake bite and insect sting.The flat sweet in the mouth of Pollen Tyjphae is returned liver, pericardium channel, and hemostasis, blood stasis dispelling, treating stranguria effect are arranged, and is used for haematemesis, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea, dysmenorrhea, gastral cavity ventral spine pain, treating swelling and pain by traumatic injury, the wet pain of stranguria with blood.The semen juglandis sweet in the mouth is warm in nature, returns kidney, lung, large intestine channel.The effect that the kidney invigorating, warming the lung, intestine moistening are arranged, be used for soreness of the waist and knees, impotence and seminal emission, deficiency and coldness breathe heavily cough, constipation.The succinum sweet in the mouth is flat, GUIXIN, liver, small intestine meridian, bladder, lung, spleen channel, and the effect of calmness, diuresis are arranged, invigorating blood circulation is used for diseases such as infantile convulsion, epilepsy, cardiopalmus, insomnia, dysuria, dysurea, hematuria, amenorrhea.
The consumption of drug component of the present invention also is to carry out a large amount of experimental results through the inventor to draw, and the following amount ranges of respectively organizing all has better curative effect:
Each amounts of components of medicine of the present invention is Cortex Cinnamomi 10～20g, Rhizoma Zingiberis Preparatum 8～22g, Radix Angelicae Sinensis 15～25g, Rhizoma Chuanxiong 15～25g, Radix Paeoniae Rubra 10～20g, Semen Persicae 10～20g, Rhizoma Cyperi 8～22g, Oletum Trogopterori 10～20g, Pollen Tyjphae 10～20g, semen juglandis 5～19g, succinum 3～7g.
Be preferably: Cortex Cinnamomi 15g, Rhizoma Zingiberis Preparatum 15g, Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 20g, Radix Paeoniae Rubra 15g, Semen Persicae 15g, Rhizoma Cyperi 15g, Oletum Trogopterori 15g, Pollen Tyjphae 15g, semen juglandis 12g, succinum 5g.
Its preparation method is as follows:
(1) takes by weighing above-mentioned 11 kinds of medicines, clean pulverization after the roguing drying respectively, mixing for standby use;
(2) mixed medicamental pulverata being crossed the bottling of 80～100 mesh sieves seals standby;
Get 1～3g medicamental pulverata when (3) treat menstrual period, be dipped in 60 ° of Chinese liquor and even, the furnishing paste, respectively ointment is filled in the umbilicus, the external immobilization with adhesive tape of breathing freely was changed dressings once in 24 hours, connected and applied 5～6 days, continuous 3 menstrual cycle are a course of treatment, general recovery from illness 1～2 course of treatment, no longer recurrence.
Characteristics of the present invention: 1. Chinese medicine treating both the principal and secondary aspects of a disease and determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle, in conjunction with traditional Chinese medical science acupoint therapy, be beneficial to the persistent ailment of eradicating menalgia;
2. nurse one's health double executing, warming and recuperating the spleen and kidney, the gate of vitality, clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling are applicable to the dysmenorrhes that cold-damp, the stasis of blood cause;
3. determined curative effect, the cure rate height, and easy to operate, not take medicine, do not have an injection, do not infuse, the no any discomfort and the pain of injury are accepted by the patient deeply.
The specific embodiment
Below routine by experiment beneficial effect of further setting forth medicine of the present invention, these test examples comprise the pharmacodynamics test and the clinical observation on the therapeutic effect test of medicine of the present invention (pasting to call the warming the meridian blood stasis dispelling in the following text).
Test example 1 warming the meridian blood stasis dispelling of the present invention pastes toxicity test
(1) acute toxicity test: choose each 10 of normal skin and artificial damaged skin SD rats, stick 5 times of ordinary person's dosage warming the meridian blood stasis dispelling respectively and paste, repeatedly stick, skin allergy and toxicity all do not occur.
(2) long term toxicity test: choose 80 of SD rats, body weight 60～80g is divided into four groups at random, and 20 every group, male and female half and half, single cage is raised.If 2 times, 5 times, 10 times three dosage groups are fried in shallow oil soup respectively and are irritated stomach to animal subject, continuous 30 days.The equal feed normal feedstuff of each treated animal of duration of test, and ad lib, drinking-water.Experiment finishes the back and puts to death rat, and liver,kidney,spleen etc. is carried out histopathologic examination's (paraffin section), result of the test such as following table.
The dirty body ratio of each treated animal of table 1 result (%)
As can be seen from Table 1, all animal liver,kidney,spleens etc. there is no obvious pathological change, illustrate the warming the meridian blood stasis dispelling paste have no side effect, safe and reliable.
The influence that 2 pairs of isolated rat uterine smooth muscles of test example shrink:
Get 50 of unpregnancy Healthy female Wistar rats, body weight 180～220g is divided into five groups.Choose YUANHU ZHITONG PIAN (main component Rhizoma Corydalis, the Radix Angelicae Dahuricae) that Chengde Tianyuan Pharmaceutical Co., Ltd. produces as positive controls, before experiment every day lumbar injection estradiol benzoate 1mg/kg, continuous 2 days.Put to death rat on the 3rd day, and cut open the belly rapidly, take out the uterus, place the glass dish that fills Rockwell liquid immediately.Get the stage casing 2cm in an Aconitum carmichaeli Debx. palace, softly peel off connective tissue and fatty tissue, an end is fixed in Magnus' bath, contains 30mL Rockwell liquid in the bath.The other end links to each other with the muscle tone transducer, is that down constant temperature bath cabinet, temperature are controlled at (37 ± 10) ℃.And constantly in Magnus' bath, feed O
2, foam control is 1～2 of per second.The input of muscle tone transducer has the computer of application software Med lab bio signal acquisition processing system.After treating that specimen is stable, trace one section normal activity curve, add successively from the Magnus' bath top and respectively organize medicinal liquid.The reagent that is subjected to that adds in this experiment is Chinese medicine (subsides of a warming the meridian blood stasis dispelling) stock solution (not containing Percutaneous absorption enhancer and substrate), and concentration is 5mg/mL, 25mg/mL, 50mg/mL respectively.Positive control drug YUANHU ZHITONG PIAN electuary concentration is 10mg/mL.Observed and recorded strength of uterine contraction (maximum) and frequency change, and calculate the suppression ratio of each index: index * 100% before suppression ratio %=(before the administration after index-administration index)/administration.
Experiment shows that the warming the meridian blood stasis dispelling pastes (medicinal liquid, down together) when 5mg/mL concentration, can effectively suppress spontaneous contraction frequency of normal isolated rat uterine smooth muscle and amplitude; During 25mg/mL, spontaneous contraction almost completely is suppressed.The results are shown in Table 2.
The influence that table 2 pair isolated rat uterine smooth muscle shrinks
Annotate: with comparison before the administration, 1) t=-6.1443 ,-14.4599 ,-3.4641 ,-5.2985 ,-10.0459, P＜0.01;
2)t’＝-5.0377、-16.1475，P＜0.01。
Test example 3
One, physical data
1. patient originates: case 150 examples are observed in this test altogether, constitutional, each 50 example of Secondary cases, and matched group 50 examples, its all cases are all from clinical.
Two, include the case standard in
With the dysmenorrhea is primary symptom, meets the Chinese medical discrimination standard, examines no significant organic pathological changes through the woman.
1. Chinese medical discrimination standard:
(1) cold and stagnate card: cold-type pain in the lower abdomen during menstruation, De Rezeshu, hypomenorrhea, color is purple dark, and clot is arranged, and is cold with extremity, and diseases such as clear urine in large amounts are to be cold and stagnate card dysmenorrhea;
(2) qi stagnation and blood stasis type: disease is seen whenever in through last two days or menstrual phase lower abdominal distention pain, tenderness, or companion's breast side of body mammary swelling, or hypomenorrhea, or blockage of menstruation, and dark menses has piece, and clot is discharged the back alleviation of pain, pain disappeared after menstruation, purplish tongue is dim or petechia, stringy pulse or stringy and rolling pulse arranged.
2. Western medicine diagnose standard
(1) primary dysmenorrhea: do not have obvious pathological changes person through the gynecologial examination genitals,, be more common in adolescence, the unmarried and married person of not educating so claim primary dysmenorrhea again;
(2) secondary dysmenorrhea: through the gynecologial examination genitals obvious pathological changes person is arranged, the dysmenorrhea that causes as symptoms such as endometriosis, pelvic inflammatory disease, tumors.
3. case is investigated
(1) secondary dysmenorrhea, the genitals has tangible organic disease, pelvic inflammatory disease, uterus tumor, endometriosis pathological changes is arranged and the dysmenorrhea that causes through check-up such as gynecologial examination, super video picture, peritoneoscopes;
(2) merge great organic disease persons such as the heart, brain, kidney, liver, lung;
(3) concurrent infection disease, malignant tumor and psychotic;
(4) use additive method treatment dysmenorrhea person or simultaneously to this medicine allergy sufferers.
Three, test method
Adopt single blind completely random grouping, treatment, 1 time on the one are pasted with Chinese prescription warming the meridian blood stasis dispelling by constitutional, secondary dysmenorrhea observation group; Matched group adopts treatment with western.Every menstrual cycle medication 5～6 days is observed 3 menstrual cycle (course of treatment) and is changed.
Four, curative effect determinate standard
" the clinical research guideline of new Chinese medicine treatment dysmenorrhea " determined curative effect determinate standard with reference to Ministry of Public Health promulgation in 1993 carries out efficacy determination.Recovery from illness: after the treatment, stomachache and other transference cures, 3 menstrual cycle of drug withdrawal are the recidivist not; Produce effects: after the treatment, stomachache obviously alleviates, and all the other symptoms take a turn for the better, and the disobedience analgesic can be adhered to work; Effectively: after the treatment, the stomachache observation of curative effect alleviates, and all the other symptoms take a turn for the better, and the clothes analgesic can be adhered to work; Invalid, stomachache and symptom thereof do not have the changer; Recurrence has clear improvement again after the treatment, but repeats stomachache.
2. two groups of comprehensive therapeutic effects see Table 3
Table 3 liang group comprehensive therapeutic effect relatively
As can be seen from Table 3, analyze through Ridit, there were significant differences (p＜0.01) for comprehensive therapeutic effect between two groups, and observation group obviously is better than matched group.
Six, conclusion
150 routine clinical test results show that this kind warming the meridian blood stasis dispelling pastes the dysmenorrhes that treatment exopathogen criminal, cold-damp, the stasis of blood are caused and has significant curative effect, and its symptomes complice curative effect total effective rate is respectively 96%.Comprehensive this Chinese herbs paste determined curative effect of contrast, application is convenient, and does not find obvious adverse reaction and toxic and side effects in application process.
Claims (5)
1. a Chinese powder medicine and preparation for the treatment of menalgia is characterized in that it mainly is that former medicine by following weight portion develops: Cortex Cinnamomi 10～20g, Rhizoma Zingiberis Preparatum 8～22g, Radix Angelicae Sinensis 15～25g, Rhizoma Chuanxiong 15～25g, Radix Paeoniae Rubra 10～20g, Semen Persicae 10～20g, Rhizoma Cyperi 8～22g, Oletum Trogopterori 10～20g, Pollen Tyjphae 10～20g, semen juglandis 5～19g, succinum 3～7g.
2. according to the medicine of claim 1, wherein the consumption of crude drug is: Cortex Cinnamomi 15g, Rhizoma Zingiberis Preparatum 15g, Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 20g, Radix Paeoniae Rubra 15g, Semen Persicae 15g, Rhizoma Cyperi 15g, Oletum Trogopterori 15g, Pollen Tyjphae 15g, semen juglandis 12g, succinum 5g.
3. claim 1 or 2 described medicaments preparation methods, it comprises the following steps:
A) take by weighing each crude drug Cortex Cinnamomi, Rhizoma Zingiberis Preparatum, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Semen Persicae, Rhizoma Cyperi, Oletum Trogopterori, Pollen Tyjphae, semen juglandis, succinum, clean after the roguing drying standby respectively;
B) with Chinese medicine cinnamon, Rhizoma Zingiberis Preparatum, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Semen Persicae, Rhizoma Cyperi, Oletum Trogopterori, Pollen Tyjphae, semen juglandis and the succinum pulverization of described deal proportioning, mixing for standby use.
4. according to medicine described in the claim 3, cross 80～100 mesh sieves, promptly get the Chinese medicinal formulae described in the claim 1.
5. Chinese medicinal formulae according to claim 4, get 1～3g medicamental pulverata when treat menstrual period, be dipped in 60 ° of Chinese liquor and even, the furnishing paste, respectively ointment is filled in and spread in the umbilicus, the external immobilization with adhesive tape of breathing freely was changed dressings once in 24 hours, connect and applied 5～6 days, continuous 3 menstrual cycle are a course of treatment, general recovery from illness 1～2 course of treatment, no longer recurrence.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102847109A (en) * | 2012-08-28 | 2013-01-02 | 赵爱良 | Navel-applied plaster for treating dysmenorrhea and preparation method thereof |
| CN105534151A (en) * | 2015-12-28 | 2016-05-04 | 吴华娟 | Traditional Chinese medicinal seat cushion for treating dysmenorrhea |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1650980A (en) * | 2004-11-30 | 2005-08-10 | 许跃华 | Preparation of medicine using formula containing angelicae sinensis radix etc. for treating gynecopathy algomenorrhea |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1650980A (en) * | 2004-11-30 | 2005-08-10 | 许跃华 | Preparation of medicine using formula containing angelicae sinensis radix etc. for treating gynecopathy algomenorrhea |
Non-Patent Citations (1)
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| 秦淑芳: "韩冰教授从任脉论治疾病的经验介绍", 《新中医》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102847109A (en) * | 2012-08-28 | 2013-01-02 | 赵爱良 | Navel-applied plaster for treating dysmenorrhea and preparation method thereof |
| CN105534151A (en) * | 2015-12-28 | 2016-05-04 | 吴华娟 | Traditional Chinese medicinal seat cushion for treating dysmenorrhea |
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Application publication date: 20111214 |