CN101698020A - Traditional Chinese medicine preparation for treating femoral head necrosis and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating femoral head necrosis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating femoral head necrosis and a preparation method thereof. The traditional Chinese medicine preparation comprises the following components in parts by weight: 10-20 parts of angelica, 10-20 parts of rhizoma ligustici wallichii, 10-15 parts of red peony root, 10-15 parts of white peony root, 10-12 parts of prepared rehmannia root, 10-12 parts of safflower, 10-15 parts of radix achyranthis bidentatae, 1-6 parts of radix aconiti, 10-15 parts of Chinese dodder seed, 10-15 parts of radix codonopsis pilosulae, 10-30 parts of astragalus root, 10-15 parts of radix dipsaci from Sichuan of China, 10-15 parts of corydalis tuber, 2-5 parts of centipede, 1-10 parts of deerhorn gelatin and 1-10 parts of licorice. The invention adopts traditional Chinese medicines which have the functions of tonifying the kidney, strengthening bone, promoting blood circulation and relieving the stasis of blood and have a certain curative effect to the femoral head necrosis, improves the blood supply dysfunction of the local artery of the femoral head necrosis, reinforces the local blood flow, promotes the regenerative formation of bone trabecula, reduces the saccular change, enhances the bone absorption, restores a cartilage position, smoothes blood vessels and recovers muscular atrophy.
Description
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of Chinese medicine preparation for the treatment of femur head necrosis and preparation method thereof.
Background technology
Femur head necrosis is a kind of chronic coxarthropathy slow, that the spontaneous recovery rate is low, disability rate is high of falling ill, and also claims aseptic necrosis of femoral head or ischemic necrosis.The traditional Chinese medical science belongs to " rheumatism involving the bone ", " osteomyelitis " category.Because primary disease is a basis with the Liver and kidney deficiency of both QI and blood, blood stasis, phlegm-damp, cold-damp are mark, the kidney generating marrow and dominating bone, and liver storing blood master muscle, deficiency of both the liver and kidney, iliacus loses foster and causes." cause of disease arteries and veins is controlled " meaning: " disease of BI-syndrome involved the kidney, promptly rheumatism involving the bone is also ", so the bone marrow inanition of suffering from a deficiency of the kidney is endogenous cause of ill; " element ask contrary transfer opinion " meaning: " kidney is not given birth to, and then marrow can not be expired, so tremble with fear even also " is the pathogenic characteristic of rheumatism involving the bone with the cold coagulation of suffering from a deficiency of the kidney, blood stasis; " element is asked lunge joint opinion " meaning: " bitterly at bone, unable to raise the limbs due to heaviness of the bones, aching pain in the bone marrow, cold to name is said rheumatism involving the bone." at present owing to long-term a large amount of uses even hormone abuse, drink for a long time or self lipid metabolism is unusual etc. that femur head necrosis that the atraumatic factor causes increases clinically gradually; and early diagnosis difficulty, disability rate are higher, and the state of an illness developed into for 2 or 3 phase even late periods during the clinical prescription on individual diagnosis of a lot of patients.
Femur head necrosis full name aseptic necrosis of femoral head, or ischemic necrosis of femoral head are that the local blood fortune of femoral head that causes owing to multiple reason is bad, thereby cause a kind of pathological changes of the further ischemia of osteocyte, necrosis, bone trabecula fracture, collapse of the femoral head.Clinical manifestation is that pain, intermittent claudication, collapse of the femoral head, joint space narrow down, and can cause osteoarthritis and cause joint function disturbance at last.The patient of whole world trouble femur head necrosis has 3,000 ten thousand people approximately at present, and China has 4,000,000 people approximately.Slow owing to this course of disease, pathogenesis is complicated, low one of the worldwide difficult and complicated illness that is put into of cure rate.Up-to-date investigation shows, this disease do not have an obvious sex difference, any age all can be ill, and had hormone to use the probability showed increased of history, hip trauma history, excessive drinking history, relevant disease history person morbidity.
Modern medicine thinks that the femur head necrosis commonly encountered diseases is following several because of having: (1) wound: as fracture of the femoral head, and dislocation of hip joint, femoral head compression injury etc.(2) because of the long-term a large amount of hormonal medicaments that use of certain disease.(3) long-term excessive drinking, congenital hip dysplasia, humidity etc.This disease does not have special Therapeutic Method at present, and mainly take conservative treatment, late period then to adopt artificial replacement's art early stage.Modern study show have invigorating the kidney and strengthening the bones, the Chinese medicine of function of promoting blood circulation to disperse blood clots has certain curative effect to femur head necrosis, can improve femur head necrosis local intra-arterial blood supply dysfunction, strengthen regional blood flow, promote bone trabecula regeneration to form, cryptomere changes dwindles, sclerotic bone absorbs, and repair at the cartilage position, and the unobstructed vessel amyotrophy recovers.
To be objective, up to now, the treatment of femur head necrosis is still very difficult, and simple non-operative treatment comprises treatment by Chinese herbs, because the existence of subsiding, its inherent limitation is arranged, only be applicable to part type or certain stage of disease, the sort ofly ignore disease Changing Pattern and characteristics, beating the way of bringing into play advantages of TCM, blindly exaggerative curative effect, both do not met scientific spirit, must bring negative effect yet, and must draw attention the sound development of tcm cause.
The difficult point of femoral head necrosis therapeutic conclude following some: considerable time after morbidity at first, the patient is without any sensation, naturally can not remove hospital admission, even moreover have advanced person, responsive diagnostic device (as MRI, ECT etc.), also can't obtain early diagnosis.So, the early treatment is just desirable, can't realize, and exactly in this stage, may be the best period of treatment by Chinese herbs achieving success; To the treatment traditional Chinese medical science methods that adopt for oral administration or external of this disease, pain relieving is slow more for many years, and treatment time is long, and effect is also not ideal; And the doctor trained in Western medicine aspect adopts operation method more, but because the expense height, success rate of operation is low, so patient also is not easy to accept.And the traditional Chinese medical science clinical accumulation over the past thousands of years has manyly to losing the effective side's medicine of headache behind the craniocerebral trauma, with its research and develop, has been inevitable rule.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine preparation for the treatment of femur head necrosis and preparation method thereof is provided.The present invention utilizes the effect of each medicine to produce synergism, can play blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, circulation of qi promoting tonify deficiency, can effectively prevent the slight illness that treating caput femoris necrosis brings, all medicines share mends double the executing of row, plays benefiting qi and nourishing yin altogether and nourishes blood, the promoting flow of QI and blood pain relieving, removing the necrotic tissue and promoting granulation, can improve femur head necrosis local intra-arterial blood supply dysfunction, strengthen regional blood flow, promote bone trabecula regeneration to form, cryptomere changes dwindles, sclerotic bone absorbs, and repair at the cartilage position, the merit of unobstructed vessel amyotrophy recovery.Chinese medicine preparation of the present invention adopts pure Chinese medicine formulated, has characteristics such as determined curative effect, safety, no obvious toxic-side effects, makes laws from aspects such as promoting flow of QI and blood, blood stasis dispelling; Deficiency syndrome have negative and positive of qi and blood not, and treatment is many starts with from tonification.Tonify deficiency is accomplished reinforcing and reducing concurrently as law, sets about from endogenous cause of ill, and the liver nourishing tonifying speen and tonifying kidney, vigorate qi and replenish the blood reaches regulating menstruation and nourishing blood, recovers the effect of the normal internal recycle of human body.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of femur head necrosis, the ratio of weight and number of described various components is: 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of the Radix Paeoniae Albas, 10～12 parts in Radix Rehmanniae Preparata, 10～12 parts on Flos Carthami, 10～15 parts of Radix Achyranthis Bidentataes, 1～6 part of Radix Aconiti, 10～15 parts of Semen Cuscutae, 10～15 parts of Radix Codonopsis, 10～30 parts of the Radixs Astragali, 10～15 parts of Radix Dipsaci, 10～15 parts of Rhizoma Corydalis, 2～5 of Scolopendras, 1～10 part of Colla cornus cervi, 1～10 part in Radix Glycyrrhizae.
The Chinese medicine preparation of described treatment femur head necrosis, the ratio of weight and number of various components can be preferably: 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of the Radix Paeoniae Albas, 10～12 parts in Radix Rehmanniae Preparata, 10～12 parts on Flos Carthami, 10～15 parts of Radix Achyranthis Bidentataes, 1～3 part of Radix Aconiti, 10～15 parts of Semen Cuscutae, 10～15 parts of Radix Codonopsis, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Dipsaci, 10～15 parts of Rhizoma Corydalis, 3～4 of Scolopendras, 1～5 part of Colla cornus cervi, 1～5 part in Radix Glycyrrhizae.
The Chinese medicine preparation of described treatment femur head necrosis, the ratio of weight and number of various components also can be preferably: 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of the Radix Paeoniae Albas, 10～12 parts in Radix Rehmanniae Preparata, 10～12 parts on Flos Carthami, 10～15 parts of Radix Achyranthis Bidentataes, 1～4 part of Radix Aconiti, 10～15 parts of Semen Cuscutae, 10～15 parts of Radix Codonopsis, 10～25 parts of the Radixs Astragali, 10～15 parts of Radix Dipsaci, 10～15 parts of Rhizoma Corydalis, 3 of Scolopendras, 5～10 parts of Colla cornus cervis, 5～10 parts in Radix Glycyrrhizae.
The Chinese medicine preparation of described treatment femur head necrosis, the ratio of weight and number of various components also can be preferably: 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of the Radix Paeoniae Albas, 10～12 parts in Radix Rehmanniae Preparata, 10～12 parts on Flos Carthami, 10～15 parts of Radix Achyranthis Bidentataes, 1～5 part of Radix Aconiti, 10～15 parts of Semen Cuscutae, 10～15 parts of Radix Codonopsis, 10～25 parts of the Radixs Astragali, 10～15 parts of Radix Dipsaci, 10～15 parts of Rhizoma Corydalis, 4 of Scolopendras, 1～10 part of Colla cornus cervi, 1～10 part in Radix Glycyrrhizae.
The Chinese medicine preparation of described treatment femur head necrosis, described pharmaceutical dosage form can be honey refining pill, hydration pill, capsule, oral liquid, granule, colloid, syrup, injection or drop;
Can every day when frying in shallow oil decoction and taking potion, fry in shallow oil twice, fry in shallow oil soup 200～300ml at every turn, clothes service once down every day sooner or later at twice, can 30 days one courses of treatment, totally 1～3 course of treatment.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of femur head necrosis, and the dosage form of described Chinese medicine preparation is a honey refining pill, its preparation method comprises: described component was soaked 30 minutes to 1 hour, heated and boiled 45 minutes is filtered filtrate for later use; Filtering residue adds water, and heating was boiled 30 minutes for the second time, refiltered filtrate for later use; Twice filtrate is lumped together, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 ℃, dries postcooling, and mixing with Mel is twisted into slice, the wax seal packing.
For solving the problems of the technologies described above, the present invention provides a kind of preparation method for the treatment of the Chinese medicine preparation of femur head necrosis again, and the dosage form of described Chinese medicine preparation is a capsule, and its preparation method comprises:
A. described Radix Aconiti, Scolopendra are put into the ethanol heating and refluxing extraction;
B. get the residue component of described Chinese medicine preparation again, add the water heating and refluxing extraction;
C. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol concentrates sucking filtration absorption, obtains medicated powder, incapsulates and is made as capsule.
Among the described step a, described Radix Aconiti, Scolopendra can be put into ethanol, described ethanol consumption is 10 times of amounts of described Radix Aconiti and Scolopendra weight portion, and heating and refluxing extraction 2 times each 30 minutes～45 minutes, leaves standstill 2 extracting solution merging.
Among the described step b, described residue component can be put into water, the consumption of described water is 10 times of amounts of described residue component weight portion sum, and heating and refluxing extraction 2 times each 30 minutes～45 minutes, leaves standstill 2 extracting solution merging.
Among the described step c, extracting solution after described two kinds can being left standstill merges, decompression recycling ethanol, and being concentrated into liquor strength is 0.6g crude drug/mL, sucking filtration is when the relative density of filtrate is 20 ℃ 1.06; After above-mentioned filtrate is the macroporous adsorptive resins absorption of 10L through volume, with the deionized water or the distilled water eluting of 10 times of resin column volumes, 95% ethanol elution of 5 times of resin column volumes of reuse, collect ethanol elution, remove solvent, obtain medicated powder, incapsulate and be made as capsule.
The present invention adopts the Chinese medicine of invigorating the kidney and strengthening the bones, function of promoting blood circulation to disperse blood clots that femur head necrosis is had certain curative effect, can improve femur head necrosis local intra-arterial blood supply dysfunction, strengthen regional blood flow, promote bone trabecula regeneration to form, cryptomere changes dwindles, sclerotic bone absorbs, repair at the cartilage position, and the unobstructed vessel amyotrophy recovers compared with prior art religion, and present technique has convenient drug administration, advantages such as medicament is easy to make, and is with low cost.The present invention adopts the Chinese crude drug of the different property of medicine, has carried out the science compatibility, can reach ideal therapeutic effect, and safety, and toxic and side effects is little, and is easy to use, and healing time is short, cures the back and is difficult for recurrence.Can create good social is worth and economic interests.
The specific embodiment
The ischemic femoral head that a variety of causes causes is the basic cause of disease of atraumatic femur head necrosis, motherland's medical science is with the category of primary disease ownership " rheumatism involving the bone ", " osteomyelitis ", think that blood-stasis internal-depression is the pathogenesis key of primary disease, the treatment aspect is the basic rule of treatment with blood circulation promoting and blood stasis dispelling, eliminating evil collateral dredging, invigorating function of kidney and strengthening bone.The traditional Chinese medical science think femur head necrosis pathological changes main diseases due to illness machine the following aspects is arranged: 1, violence is hindered: because extraneous violence, wound cause the lighter's skin and flesh impaired, weight person's organizational structure is destroyed fracture, the stasis of blood is stagnant suddenly to make QI and blood, disorder of QI movement, check venation, venation is obstructed, qi depression to blood stasis, the femoral head local blood is supplied with and is obstructed, thereby femur head necrosis takes place.With the passing of time violence is hindered and is not healed, and involves Liver and kidney, caused by liver and kidney deficiency, and asthenia of essence and blood, bone is become homeless foster, generation femur head necrosis of a specified duration.2, six climate exopathogens are hindered: wind-cold damp pathogen is hindered, and mainly is to experience the cold-damp heresy, and the heresy of cold-damp is containing, insufficiency of kidney-YANG, and deficient qi and blood, qi depression to blood stasis is due to exopathogen is attacked.Yang-energy is obstructed, and QI and blood is agitated unable, and QI-blood circulation is not smooth, and the resistance of venation numbness is obstructed, and bone is become homeless foster, and qi depression to blood stasis, the mistake of muscle arteries and veins is supported, wins in the YANG QI deficiency, YIN-cold, and coagulation of QI-blood, not warm extremity, sending out is femur head necrosis.3, evil poison is hindered: evil poison is the poison of medicine, invades in the malicious heresy, and the Liver and kidney spleen is impaired, and the function disorder causes the ascending or descending movement of vital Qi functional disorder, deficiency of both the liver and kidney of a specified duration.Liver governing tendons, kidney governing bones, muscles and bones links to each other, and is to close outside the Liver and kidney, and liver blood is full, and muscles and bones must support that then function of joint is normal.The prolonged illness kidney is got involved, and insufficiency of kidney-YANG, spleen lose in warm, the biochemical weary source of QI and blood, and osteogenesis is unfavorable.Because the interdependence between yin and yang alternate, insufficiency of kidney-YANG, the moon are refined to give birth to and are had no way of, and cause the cloudy damage of essence void of Liver and kidney, thus QI and blood deficiency, deficiency of the liver and kindey, the brain inanition, the bone of suffering from a deficiency of the kidney then withered and need not, osteoporosis of a specified duration.Deficiency of spleen-QI, no resource of generating and transforming QI and blood, muscle contracture, joint stuffiness, the femur head necrosis that then takes place of a specified duration.Studies confirm that long-term a large amount of hormones that use can cause immunologic hypofunction in the body, cause insufficiency of kidney-YANG, are easy to bring out primary disease.4, natural endowment deficiency: congenital congenital deficiency, deficiency of both the liver and kidney, the femoral head epiphyseal dysplasia is easy to necrosis, or acetabular dysplasia, and femoral head contains not enough, all can cause femur head necrosis.5, the day after tomorrow, mistake was supported: the foundation of acquired constitution is spleen, and the congenital foundation is kidney, the transformation and transportation of the spleen and stomach imbalance, and essence of water and grain is not given birth to, be difficult to moisten foster body, congenital kidney essense can not get day after tomorrow essence of water and grain and supplements nutrition, then deficiency of kidney-essence, the kidney generating marrow and dominating bone, the deficiency of kidney-essence bone is become homeless foster, and femur head necrosis easily takes place.6, impairment caused by overstrain is excessive: impairment caused by overstrain is excessive, injures QI and blood, and insufficiency of vital energy and blood, muscle arteries and veins skeleton lose to be supported, and extremity bones of the body collectively and function of joint activity all rely moistens fosterly in QI and blood warm, and femoral head can not get abundant blood supply, also can cause osteoporosis, easily sends out femur head necrosis.
In sum, it is considered herein that the femur head necrosis pathological changes no matter the cause of disease why, its pathogenesis is the most key with stagnation of QI-blood, caused by liver and kidney deficiency, for this reason, with blood circulation promoting and blood stasis dispelling, nourishing the liver and kidney, invigorating the spleen and benefiting QI, the strong muscle of bone strengthening is that method is founded we, and clinical use is achieved good results.The present invention adopts pure Chinese medicine formulated, has characteristics such as determined curative effect, safety, no obvious toxic-side effects.How to make laws from aspects such as promoting flow of QI and blood, blood stasis dispelling; Deficiency syndrome have negative and positive of qi and blood not, and treatment is many starts with from tonification.Tonify deficiency is accomplished reinforcing and reducing concurrently as law.Liver and kidney belongs to cloudy, and spleen also belongs to the moon.The spleen being the foundation of acquired constitution is also worked as tonification, to strengthen the power of its fortuneization.This three cloudy benefit together is that " strengthening renal yin to inhibit predominant yang is with system sunlight." invigorating middle warmer has and rush down, it is turbid then can to lead kidney off, pancake liver-fire, and the stagnate drawback of spleen of the greasy stomach of drugs for nourishing yin is removed in the eliminating dampness by diuresis spleen invigorating.Moreover, the QI invigorating in the ban of enriching blood.Because of qi being the governor of blood, blood being the material foundation of QI, gas are the son of blood, and the capable then blood of gas is capable.Selected QI invigorating medicine in the event side is realized qi and blood tonifying.When be slow mend and in, become empty and lose to substantial." following the law of YIN YANG will bring about a benificial consequence, violating the law of YIN YANG will bring a harmful consequence in a word." the present invention mainly sets about from endogenous cause of ill, the liver nourishing tonifying speen and tonifying kidney, vigorate qi and replenish the blood reaches regulating menstruation and nourishing blood, recovers the effect of the normal internal recycle of human body.The traditional Chinese medical science think with femur head necrosis pathological changes relation the closest for liver,spleen,kidney three dirty.The kidney being the origin of congenital constitution, and main bone is given birth to marrow, and the strong then marrow of kidney fills, and marrow is the bone heavily fortified point completely then; Otherwise then the marrow dry bones withers, and loses the regeneration capacity of application.The liver governing tendons store blood, with the kidney homology, two dirty honor decline together, if liver gets involved, store blood mistake department can not the normal regulating blood volume, nutrition is not good, also is the key factor that causes ischemia femur head necrosis.Taste be the day after tomorrow this, all things on earth the source of vital function, spleen is good for the stomach and, then paddy is not become thoroughly decomposed, activating QI blood is defended with the field headquarters, if taste lose strong fortune, biochemical QI and blood is passive, then muscles and bones muscle all depletion of QI with life.
Radix Rehmanniae Preparata nourishing YIN and benefiting blood in the side; Radix Astragali QI invigorating, the prosperous then cloudy blood of gas is spontaneous; Radix Codonopsis clears away heart-fire and invigorates blood circulation, and makes tonify without causing stagnation; Radix Paeoniae Alba energy dissipating blood stasis blood, removing blood stasis stimulate the menstrual flow; Rhizoma Chuanxiong, Radix Dipsaci are arrogated to oneself mediation, the up head, and the descending sea of blood is gas medicine in the blood, is the pain relieving panacea; Chinese angelica blood supplementing is moisturized, the blood stasis dispelling of stimulating the menstrual flow; Radix Achyranthis Bidentatae, Colla cornus cervi QI invigorating yin fluid astringing help QI invigorating to give birth to the power of the moon; Radix Paeoniae Rubra is nourshing Yin and drynsessmoistening prescription, clearing heat and relieving fidgetness; The Flos Carthami medicine carrying is up, makes the efficacy of a drug up, but qi and blood circulation promotion is grown and oiliness all medicines, and benefit is not stayed the stasis of blood; Gas in the Semen Cuscutae the kidney invigorating benefit; Scolopendra is to poison the stasis of blood; The Radix Aconiti removing blood stasis; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription alleviates toxicity; All medicines share mends double the executing of row, playing benefiting qi and nourishing yin altogether nourishes blood, the promoting flow of QI and blood pain relieving, removing the necrotic tissue and promoting granulation can improve femur head necrosis local intra-arterial blood supply dysfunction, strengthen regional blood flow, promote bone trabecula regeneration to form, cryptomere changes dwindles, and sclerotic bone absorbs, repair at the cartilage position, the merit of unobstructed vessel amyotrophy recovery.
Radix Angelicae Sinensis: its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
The Radix Astragali is based on tonify deficiency, can invigorating QI to consolidate the body surface resistance, and diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and the energy enhancing body's immunological function, therefore can also be used to prevent the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " Radix Astragali can all void of tonifying five ZANG-organs, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.
Radix Codonopsis is flat, sweet in the mouth, little acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst." book on Chinese herbal medicine justice " carries: Radix Codonopsis power energy spleen reinforcing nourishing the stomach, and the lung moistening and production of body fluid promoting, gas in the tendon fortune, this is very mutually not far away with Radix Ginseng.Its outstanding valuable person, spleen invigorating fortune and not dry is then grown stomach-Yin and wet, and lung moistening and do not violate is cold and coolly nourished blood and is not grown greasyly partially, inspires clear sun, gas in the vibration, and do not have dry fraud just.Radix Astragali QI invigorating, can rise enriching spleen-QI, again can the lung benefiting consolidating superficial resistance.The Radix Codonopsis QI invigorating can only the spleen invigorating QI invigorating, the power of no consolidating superficial resistance, but Radix Codonopsis can also supplementing QI for promoting the production of body fluid, and the Radix Astragali does not then have the effect of promoting the production of body fluid, and the Radix Astragali is held concurrently can diuretic, and Radix Codonopsis does not have the diuretic effect.This two flavors medicine share can invigorating the spleen and replenishing QI, improves resistance.
The Rhizoma Chuanxiong suffering, temperature.Go into liver, gallbladder meridian.Activating QI to alleviate the depression, the method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache and revolve dizzyly, the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." herbal classic " carries it: main apoplexy is gone into the brain headache, arthralgia due to cold, and the clonic spasm of the muscle emergency, the gold wound, married woman's blood closes loss of fecundity." not Lu " carries it: " remove in the brain cold movingly, urticaria goes on the face, the order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, the soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." be the good medicine of regulating qi to disperse stagnation.
The Radix Rehmanniae Preparata nature and flavor are sweet, slightly warm in nature.Return liver, kidney channel.Cure mainly and have the YIN nourishing of enriching blood effect and be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, diseases such as metrorrhagia.Can be used for deficiency of kidney yin hectic fever hectic fever due to YIN-deficiency, night sweat, pass out semen, quench one's thirst etc., as LIUWEI DIHUANG WAN.The vital essence replenishing and marrow benifiting effect is used for the Liver and kidney essence and blood and loses empty soreness of the waist and knees, vertigo and tinnitus, early whitening of beard and hair etc.Radix Rehmanniae Preparata sweet in the mouth tepor matter profit, the YIN nourishing of both having enriched blood again can vital essence replenishing and marrow benifiting.Being equipped with Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong as Radix Rehmanniae Preparata is exactly " SIWU TANG " of of great reputation treatment blood deficiency disease.Radix Rehmanniae Preparata is joined the nourishing the liver of Radix Paeoniae Alba energy, joins Semen Platycladi and nourishes heart, and joins Arillus Longan and can support spleen.
Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to invigorate blood circulation latus rectum, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy goes into the blood chamber, and delirium is gone mad; Or blood expands in vexed, and the sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be decided.All friendship as the obstructed and cold and heat of amenorrhea done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollenly burst uneasyly, is cards of disharmony between QI and blood all, and non-Flos Carthami can not be transferred.
Scolopendra is salty, hot, temperature.Poisonous.Return liver, spleen, lung meridian.Function cures mainly endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain.Be used for infantile convulsion, the tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom, moves back inflammation and controls skin ulcer at anticancer, the relieving spasm by calming endogenous wind of relieving internal heat, and is the good medicine of blood circulation promoting and blood stasis dispelling.
The Radix Paeoniae Rubra bitter in the mouth is slightly cold.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.The Radix Paeoniae Rubra branch excess-heat that can purify the blood, dissipating blood stasis blood is detained.This product function and Cortex Moutan are close, so normal be usefulness with the Cortex Moutan mutual reinforcement between.But the effect of Cortex Moutan clearing away heat and cooling blood is preferable, and the branch excess-heat that can purify the blood can be controlled fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for the blood system excess-heat, is good at promoting blood circulation to remove blood stasis.
The Radix Paeoniae Alba goes into liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and all diseases in antenatal back, Tong Yueshui brings down a fever, relieving restlessness, QI invigorating, day hot disease of row, the pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the skin ulcer scabies, headache makes eye bright, and conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.
Semen Cuscutae Gan Xinping goes into liver, kidney channel.The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antiabortive.Be used for caused by liver and kidney deficiency, soreness of waist and knee joint, impotence and seminal emission, frequent urination and enuresis, two blurred visions are dark, diseases such as frequent fetal movement.The function tonification Liver and kidney, the controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright antidiarrheal.Being used for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen suffers from a deficiency of the kidney and rushes down; The good medicine of externally treating leucoderma.Semen Cuscutae can also promote melanocyte propagation and melanocyte to synthesize, to the activation of tryrosinase.
Radix Achyranthis Bidentatae drug effect height, Li Shizhen (1518-1593 A.D.) is said it: the merit of nourishing, as the power of cattle.Radix Achyranthis Bidentatae abnormal smells from the patient picric acid is flat, cures mainly cold-damp flaccidity syndrome and arthralgia syndrome, spasm of the limbs, the gonalgia unable to flex and stretch the extremities, and by vim and vigour, the fire of getting mildewed in warm conditions is mashed, and clothes are made light of one's life by commiting suicide anti-old for a long time.1. wherein contained alkaloid has good hypotensive effect.2. contained ecdysterone can improve liver function, reduces plasma cholesterol, and the effect of cell activity enhancing is arranged.3. be rich in Inokopolyose the effect of tangible enhancing humoral immune function is arranged.4. to the human body low or body of gland atrophy of zinc, endocrine function that manganese causes for want of, pathological changes such as poor growth, sexual impotence, infertile, habitual abortion have curative effect preferably.5. have antiinflammatory and analgesic activity.6. has the function that the calculus of gallbladder, kidney, bladder, urethra is dissolved and excreted.7. its effective ingredient has certain excited uterus, anti-aging effects.8. diuresis, spasmolysis.So good medicine that its blood circulation promoting and blood stasis dispelling simply is healthy and strong.
Radix Aconiti suffering, hardship, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.The function expelling wind and removing dampness, antalgic.Be used for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.But be used for removing blood stasis for oral administration on a small quantity.Be in harmonious proportion its toxicity with Radix Glycyrrhizae among the we, make its drug effect can maximum performance.
The Radix Dipsaci toil, tepor, invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating.Cure mainly: control aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, seminal emission, traumatic injury, incised wound, anal fistula, the carbuncle skin ulcer is swollen.Be the good medicine of removing the necrotic tissue and promoting granulation simply.
Rhizoma Corydalis, acrid in the mouth, hardship, temperature.Pericardium, liver, spleen, lung.Promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain.Be the good medicine of promoting blood circulation to remove blood stasis.
Colla cornus cervi is controlled deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, women's deficiency-cold of uterus, metrorrhagia, leukorrhagia.Enrich blood, benefit is smart.Control deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, women's deficiency-cold of uterus, metrorrhagia, leukorrhagia." herbal classic " carries it: " main damaging the spleen and stomach labor is exhausted; The lumbago weakness and emaciation, invigorating the spleen and replenishing QI, married woman's blood closes loss of fecundity, and pain relieving is antiabortive." " not Lu " carries it: " treated and spitted blood, hematochezia, and metrorrhagia is more than, painful limbs, hyperhidrosis is drenched and is revealed, and folding is got injured by a fall damage." " property of medicine opinion " carry its: " main man's kidney is hidden the weakness of QI asthenia and is contributed, and can antiabortively go coldly, controls whitish metrorrhagia, the main haematemesis." " Bencao Jingshu ": " all Lao Zhiren that does, middle impairment of QI is exhausted, and extremity are had a pain, hyperhidrosis or haematemesis hematochezia, all liver, the heart are subjected to disease.White glues sweet in the mouth temperature, go into two through and can strengthening QI of middle-JIAO, then exhausted hinder and, extremity profit, blood from end, antiperspirant is from holding back also.Folding is got injured by a fall damage, and then blood stasis forms disease, and Gan Wen goes into blood, and the current tonification of holding concurrently again is so folding is got injured by a fall damage spontaneous recovery.Married woman's blood closes loss of fecundity, and metrorrhagia drench to reveal, and the tire pain is uneasy, lumbago weakness and emaciation person, and marquis of blood deficiency deficiency of the liver and kindey all, warming the liver the kidney invigorating benefit blood, then all cards are supported also and tire is contented from moving back." " book on Chinese herbal medicine converges and says ": " Colla cornus cervi, kidney-Yang invigorating, the gas of enriching blood, the spermatogenesis marrow, the medicine of warm muscles and bones is also.Preceding ancient main damaging the spleen and stomach labor is exhausted, lumbago weakness and emaciation, the gas marrow muscles and bones the intestines and stomach of enriching blood.The treatment of deficiency-syndrome by reinforcement, damage person trains it, exhausted person continuous it, timid person strong it, cold person warm it, this is the essence of blood genus, than the vegetation mercilessness, more increases the power of raising.″
Radix Glycyrrhizae property is flat, and sweet in the mouth is returned 12 warps.Detoxifcation arranged, eliminate the phlegm, pain relieving, spasmolytic be so that pharmacological action such as anticancer.On the traditional Chinese medical science, the Radix Glycyrrhizae invigorating the spleen and replenishing QI is grown and to be coughed lung moistening, and the emergency detoxifcation is in harmonious proportion hundred medicines.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Shennong's Herbal is classified Radix Glycyrrhizae as top grade, says that Radix Glycyrrhizae has the merit of hard muscles and bones, longue meat, times strength and detoxifcation, and energy treating disorders in five ZANG-organs six internal organs cold and heat pathogen and incised wound are swollen." Mingyi Bielu " say Radix Glycyrrhizae can warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, cough-relieving quench the thirst, separate hundred poison of drug.
The present invention utilizes the effect of each medicine to produce synergism, can play blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, circulation of qi promoting tonify deficiency, can effectively prevent the slight illness that treating caput femoris necrosis brings, all medicines share mends double the executing of row, plays benefiting qi and nourishing yin altogether and nourishes blood, the promoting flow of QI and blood pain relieving, removing the necrotic tissue and promoting granulation, can improve femur head necrosis local intra-arterial blood supply dysfunction, strengthen regional blood flow, promote bone trabecula regeneration to form, cryptomere changes dwindles, sclerotic bone absorbs, and repair at the cartilage position, the merit of unobstructed vessel amyotrophy recovery.
The manufacturing process of the present invention's honey refining pill is: Radix Angelicae Sinensis 200g, Rhizoma Chuanxiong 200g, Radix Paeoniae Rubra 150g, Radix Paeoniae Alba 150g, Radix Rehmanniae Preparata 120g, Flos Carthami 120g, Radix Achyranthis Bidentatae 150g, Radix Aconiti 60g, Semen Cuscutae 150g, Radix Codonopsis 150g, Radix Astragali 300g, Radix Dipsaci 150g, Rhizoma Corydalis 150g, 30 of Scolopendras, Colla cornus cervi 100g, Radix Glycyrrhizae 100g soaks medical material 30 minutes to 1 hour, heated and boiled 45 minutes is filtered filtrate for later use; Filtering residue adds water, and heating was boiled 30 minutes for the second time, refiltered filtrate for later use; Twice filtrate is lumped together, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 ℃, and powdered being mixed in Mel of oven dry postcooling is twisted into slice; With every 5g is ball wax seal packing.
The manufacturing process of capsule of the present invention is: get Radix Aconiti 60g, 40 of Scolopendras are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, and each 45 minutes, extract active ingredient, 2 extracting solution are merged leave standstill.Get Radix Angelicae Sinensis 200g, Rhizoma Chuanxiong 200g, Radix Paeoniae Rubra 150g, Radix Paeoniae Alba 150g, Radix Rehmanniae Preparata 120g, Flos Carthami 120g, Radix Achyranthis Bidentatae 150g, Semen Cuscutae 150g, Radix Codonopsis 150g, Radix Astragali 300g, Radix Dipsaci 150g, Rhizoma Corydalis 150g, Colla cornus cervi 100g, Radix Glycyrrhizae 100g add 10 times of water gagings, heating and refluxing extraction 2 times, each 1 hour, 2 extracting solution are merged; Merge above-mentioned two kinds of extracting solution, decompression recycling ethanol and to be concentrated into liquor strength be 0.6g crude drug/mL, behind the sucking filtration, the relative density of filtrate is about 1.06 (20 ℃); Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, and with the deionized water or the distilled water eluting of 10 times of resin column volumes, 95% ethanol elution of 5 times of resin column volumes of reuse is collected ethanol elution, removes solvent, obtains the component medicine earlier; Incapsulate and be made as capsule, every capsules dress 0.3g.Can per 12 be one edition.
The manufacturing process of powder Chinese patent medicine of the present invention is: Radix Angelicae Sinensis 150g, Rhizoma Chuanxiong 150g, Radix Paeoniae Rubra 150g, Radix Paeoniae Alba 150g, Radix Rehmanniae Preparata 100g, Flos Carthami 120g, Radix Achyranthis Bidentatae 150g, Radix Aconiti 60g, Semen Cuscutae 150g, Radix Codonopsis 150g, Radix Astragali 200g, Radix Dipsaci 150g, Rhizoma Corydalis 150g, 40 of Scolopendras, Colla cornus cervi 100g, Radix Glycyrrhizae 100g, described component mixes by proportioning, drops into pulverizer and is ground into fine powder, put into the acid and alkali-resistance infusion kettle after fine powder sieves, at normal temperatures, flooded 10～20 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, and heating is concentrated into pasty state, put into baking oven, be controlled at 100 ℃, the oven dry postcooling is pulverized the back with every bag of 4～6g packing.Can directly take after mixing it with water during use.
Pharmacology's toxicity test
1. skin irritation test
Get rabbit and shave hair, induce and excite contact test with external used medicine breast patch of the present invention, viewing test rabbit after 24 hours and 48 hours, all loseing skin has phenomenons such as erythema and edema, with the negative control group zero difference.The result shows that this patch is bordering on zero to dermoreaction intensity, does not promptly have skin allergic reaction.
2. endo-medicine cumulative toxicity test report
Test method: select 20 healthy mices for use, female, male each 10, dosage designs per 5 days and is first phase, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Weighed once in per 5 days, and adjusted dosage, press 0.1ml/10 part BW per os and irritate stomach.After 20 days, animal does not have death condition takes place, and off-test is tried thing after 20 days by ascending-dose, and female, buck does not all have death condition and takes place.
3. acute toxicity test
Give the white mouse oral administration medicine supplying with 300 times of the clinical consumption per day of this product endo-medicine, observed 5.All animals are strong as a result deposits, and its activity, diet, hair, Excreta are no abnormal, do not see toxic reaction.The white mouse damaged skin is carried out irritation test, and not seeing has irritative response and other untoward reaction.
Toxicity test proves, not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable.
4. long term toxicity test:
Chinese medicine preparation of the present invention to mice by 7.69,19.18 and the 43.21g crude drug/15 weeks of kg continuous use (1.0ml/100g body weight, every day 2 times) and after 3 week of drug withdrawal, the result shows: Chinese medicine preparation of the present invention does not all have obvious influence to indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, the internal organs naked eyes do not find that difference changes and the histological examination result shows, after 15 weeks of medication and 3 weeks of drug withdrawal, each internal organs of rat all do not have obvious change.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to the rat long-term prescription, also do not have the difference reaction after the drug withdrawal, application safety.
The pharmacological experiment explanation:
From in January, 2003, my institute diagnoses and criterion of therapeutical effect according to the unified of national ischemic necrosis of femoral head, adopt the method for completely random contrast, patient to 300 routine femur head necrosiss and each position osteonecrosis has carried out observation of curative effect, wherein there are 69 routine femur head necrosis patients to make operation, decompression operation 42 examples, bone grafting operation 32 examples at certain large hospital, femoral head resection operation 1 example is done femoral head and is rotated 1 example.Do once 40 examples of operation, do 22 examples of two operations, do 5 examples of three operations.300 examples are pressed: marcus by stages, I-II phases 110 example, III phase-IV phases 100 example; VVI phases 90 example, predetermined treatment duration obtains satisfied effect by stages.Now be summarized as follows:
One, clinical data
1, case is selected
Select 300 examples, wherein outpatient service 205 examples.95 examples of being in hospital, the classical symptom of femur head necrosis and each position osteonecrosis, sign, before the treatment all through X line pathological staging and main indications, CT examination, observe the size of sequestrum piece from cross-section layering, nuclear magnetic resonance, MRL checks confirmation, the size of femur head necrosis and each position osteonecrosis, the osteonecrosis district is out of shape and subsides, and the disease of arthrostenosis is shone.According to tcm syndrome differentiation and typing, deficiency of kidney-QI 90 examples, yang deficiency of spleen and stomache 150 examples; Caused by hepatic stagnation qi stagnation 35 examples; Tire natural endowment marrow deficiency will be lost dysplasia 25 examples of nourishing one's nature the day after tomorrow.
2, physical data
Case is selected 300 examples, wherein: male 142 examples, women 158 examples, age (1-12 year) 11 examples; (13-20 year) 29 examples: (21-40 year) 180 examples; (41-60 year) 30 examples; 50 examples more than 60 years old, the course of disease is the longest 15 years, and is the shortest 10 months;
Ill 1 year with interior 88 examples; (1-6) year 150 examples; (6-10) year 52 examples; 10 examples more than 10 years.
Two, Therapeutic Method:
1, outpatient service, femur head necrosis of being in hospital and position osteonecrosis patient, dialectical the executing of Chinese medicine controlled, the detailed survey cause of disease, pathological change, reasonable change, rational use of drug, pill of the present invention for oral administration, usage every day three times, each ball, warm boiled water.Three months is a course of treatment.Two recoveries from illness course of treatment of I-II phase, III-IV phase 3-4 the recovery from illness course of treatment, five of V-VI (later stage) are almost recovered or thoroughly recovery from illness the course of treatment, effective percentage 96%, cure rate 87%.
Three, efficacy analysis
1, cure: pain disappears around the hip joint, and function is improved normal, and walk not have and walk lamely, the prompting of 4 words test (bend, stretch, open up, revolve) .X radiograph, the femur head necrosis district all absorbs, and area of new bone forms.The perichondrium tissue repair, 2 kilometers of walkings are asymptomatic, participate in manual labor and work.
2, produce effects: pain disappears, and function is improved, and does not have limping on foot substantially, the test of 4 words, and the osteonecrosis district absorbs, and area of new bone forms, the perichondrium tissue repair, 2 kilometers buttocks acid precipitation of walking do not have painful sense.
3, take a turn for the better: minority femur head necrosis patient, curative effect of medication still can.Pain disappears substantially, and function is obviously improved, rare limping; Osteonecrosis is most of to be absorbed, but does not accomplish the end in view by absorbing the expected time of arrival.Extend the period of treatment slightly and can fully recover.
4, curative effect of medication is not obvious, can control the development of osteonecrosis district, and symptom can be alleviated, and curative effect has improvement, but not obvious, heavy when light during the rheumatic and rheumatoid type, but the femur head necrosis district absorbs by the pre-treatment phase, and area of new bone forms, all still can, it is slower that function is improved, extended treatment expected time of arrival.
Four, therapeutic outcome
| Phase is other | Patient's number | Recovery from illness number (%) | The number that is almost recovered (%) | Effective number (%) | Invalid number (%) |
| In early days | ??152 | ??112(73.68) | ??32(21) | ??8(5.2) | ??0 |
| Mid-term | ??85 | ??49(57.65) | ??21(24.7) | ??6(7) | ??4(4.7) |
| Phase is other | Patient's number | Recovery from illness number (%) | The number that is almost recovered (%) | Effective number (%) | Invalid number (%) |
| Late period | ??63 | ??31(49.2) | ??17(26.98) | ??8(12.7) | ??7(11.1) |
| Add up to | ??300 | ??192(64) | ??70(23.3) | ??22(7.3) | ??11(3.4) |
Specific embodiment 1: Chen, the man, 54 years old, it was surplus to suffer from right lateral thigh head necrosis 2 years, lower extremity paralysis active half a year.All do not have positive effect through each big or small hospitalize, PD is more and more heavier, causes lower extremity paralysis at last, Chinese medicine of the present invention is used in here over 2003, uses following prescription: Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 20g, Radix Paeoniae Rubra 15g, Radix Paeoniae Alba 15g, Radix Rehmanniae Preparata 12g, Flos Carthami 12g, Radix Achyranthis Bidentatae 15g, Radix Aconiti 6g, Semen Cuscutae 15g, Radix Codonopsis 15g, Radix Astragali 30g, Radix Dipsaci 15g, Rhizoma Corydalis 15g, 3 of Scolopendras, Colla cornus cervi 10g, Radix Glycyrrhizae 10g, take 30 days pain and obviously alleviate, the walking of can standing in 60 days continues medication 30 days, pain disappears substantially, walks freely after treatment drug withdrawal in 30 days again, so far do not have recurrence, generation has no side effect.
Specific embodiment 2: Liu, woman, 49 years old, suffer from the right lateral thigh head necrosis 4 years, and used treatments such as physical therapy, Chinese medicine always, can only relief of symptoms, whenever overcast and rainy, night, pain increases the weight of during heavy burden, here over 2005, use Chinese medicine of the present invention, use following prescription: Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 20g, Radix Paeoniae Rubra 15g, Radix Paeoniae Alba 15g, Radix Rehmanniae Preparata 12g, Flos Carthami 12g, Radix Achyranthis Bidentatae 15g, Radix Aconiti 5g, Semen Cuscutae 15g, Radix Codonopsis 15g, Radix Astragali 30g, Radix Dipsaci 15g, Rhizoma Corydalis 15g, 4 of Scolopendras, Colla cornus cervi 10g, Radix Glycyrrhizae 10g, pain obviously alleviated in 25 days, pain disappears substantially after 2 months, continue medication 1 month, slight pain, after treatment drug withdrawal in 1 month are only arranged when bearing a heavy burden, so far do not have recurrence, generation has no side effect.
Specific embodiment 3: seal certain, the man 66 years old, suffers from the left side femur head necrosis more than 5 years, can not stand, can not walk, my institute sees a doctor over 2003, uses Chinese medicine of the present invention, use following prescription: Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 20g, Radix Paeoniae Rubra 15g, Radix Paeoniae Alba 15g, Radix Rehmanniae Preparata 12g, Flos Carthami 12g, Radix Achyranthis Bidentatae 15g, Radix Aconiti 3g, Semen Cuscutae 15g, Radix Codonopsis 15g, Radix Astragali 20g, Radix Dipsaci 15g, Rhizoma Corydalis 15g, 3 of Scolopendras, Colla cornus cervi 10g, Radix Glycyrrhizae 10g, the obvious effect of 7 daybreaks can be stood, can walk in 35 days, walking has pain by chance freely after 3 months, after treatment drug withdrawal in 1 month does not have recurrence so far, has no side effect.
Specific embodiment 4: Bai, man, 42 years old, suffered from bilateral femoral head downright bad 3 years, and used physical therapy always, the treatment of methods such as plaster, all can only alleviate, can not effect a radical cure, over 2005 see a doctor in here, use Chinese medicine of the present invention, use following prescription: Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 20g, Radix Paeoniae Rubra 15g, Radix Paeoniae Alba 15g, Radix Rehmanniae Preparata 12g, Flos Carthami 12g, Radix Achyranthis Bidentatae 15g, Radix Aconiti 4g, Semen Cuscutae 15g, Radix Codonopsis 15g, Radix Astragali 25g, Radix Dipsaci 15g, Rhizoma Corydalis 15g, 4 of Scolopendras, Colla cornus cervi 10g, Radix Glycyrrhizae 10g, pain obviously alleviated in 15 days, painless at ordinary times after 1 month, pain when walking is born a heavy burden, after 3 months when bearing a heavy burden walking accidental pain, painless substantially after 5 months, after treatment drug withdrawal in 1 month does not have recurrence so far, and generation has no side effect.
Claims (10)
1. a Chinese medicine preparation for the treatment of femur head necrosis is characterized in that, the weight ratio of various components is: 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of the Radix Paeoniae Albas, 10～12 parts in Radix Rehmanniae Preparata, 10～12 parts on Flos Carthami, 10～15 parts of Radix Achyranthis Bidentataes, 1～6 part of Radix Aconiti, 10～15 parts of Semen Cuscutae, 10～15 parts of Radix Codonopsis, 10～30 parts of the Radixs Astragali, 10～15 parts of Radix Dipsaci, 10～15 parts of Rhizoma Corydalis, 2～5 of Scolopendras, 1～10 part of Colla cornus cervi, 1～10 part in Radix Glycyrrhizae.
2. according to the Chinese medicine preparation of the described treatment femur head necrosis of claim 1, it is characterized in that the ratio of weight and number of various components is: 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of the Radix Paeoniae Albas, 10～12 parts in Radix Rehmanniae Preparata, 10～12 parts on Flos Carthami, 10～15 parts of Radix Achyranthis Bidentataes, 1～3 part of Radix Aconiti, 10～15 parts of Semen Cuscutae, 10～15 parts of Radix Codonopsis, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Dipsaci, 10～15 parts of Rhizoma Corydalis, 3～4 of Scolopendras, 1～5 part of Colla cornus cervi, 1～5 part in Radix Glycyrrhizae.
3. according to the Chinese medicine preparation of the described treatment femur head necrosis of claim 1, it is characterized in that the ratio of weight and number of various components is: 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of the Radix Paeoniae Albas, 10～12 parts in Radix Rehmanniae Preparata, 10～12 parts on Flos Carthami, 10～15 parts of Radix Achyranthis Bidentataes, 1～4 part of Radix Aconiti, 10～15 parts of Semen Cuscutae, 10～15 parts of Radix Codonopsis, 10～25 parts of the Radixs Astragali, 10～15 parts of Radix Dipsaci, 10～15 parts of Rhizoma Corydalis, 3 of Scolopendras, 5～10 parts of Colla cornus cervis, 5～10 parts in Radix Glycyrrhizae.
4. according to the Chinese medicine preparation of the described treatment femur head necrosis of claim 1, it is characterized in that the ratio of weight and number of various components is: 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of the Radix Paeoniae Albas, 10～12 parts in Radix Rehmanniae Preparata, 10～12 parts on Flos Carthami, 10～15 parts of Radix Achyranthis Bidentataes, 1～5 part of Radix Aconiti, 10～15 parts of Semen Cuscutae, 10～15 parts of Radix Codonopsis, 10～25 parts of the Radixs Astragali, 10～15 parts of Radix Dipsaci, 10～15 parts of Rhizoma Corydalis, 4 of Scolopendras, 1～10 part of Colla cornus cervi, 1～10 part in Radix Glycyrrhizae.
5. according to the Chinese medicine preparation of each described treatment femur head necrosis in the claim 1～4, it is characterized in that the dosage form of described Chinese medicine preparation is: honey refining pill, hydration pill, capsule, oral liquid, granule, colloid, syrup, injection or drop.
6. one kind as the preparation method of the Chinese medicine preparation of treatment femur head necrosis as described in each in the claim 1～4, it is characterized in that, the dosage form of described Chinese medicine preparation is a honey refining pill, its preparation method comprises: described component was soaked 30 minutes to 1 hour, heated and boiled 45 minutes, filter filtrate for later use; Filtering residue adds water, and heating was boiled 30 minutes for the second time, refiltered filtrate for later use; Twice filtrate is lumped together, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 ℃, dries postcooling, and mixing with Mel is twisted into slice, the wax seal packing.
7. one kind as the preparation method of the Chinese medicine preparation of treatment femur head necrosis as described in each in the claim 1～4, it is characterized in that the dosage form of described Chinese medicine preparation is a capsule, and its preparation method comprises:
A. described Radix Aconiti, Scolopendra are put into the ethanol heating and refluxing extraction;
B. get the residue component of described Chinese medicine preparation again, add the water heating and refluxing extraction;
C. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol concentrates sucking filtration absorption, obtains medicated powder, incapsulates and is made as capsule.
8. according to the preparation method of the Chinese medicine preparation of the described treatment femur head necrosis of claim 7, it is characterized in that, among the described step a, described Radix Aconiti, Scolopendra are put into ethanol, described ethanol consumption is 10 times of amounts of described Radix Aconiti and Scolopendra weight portion, heating and refluxing extraction 2 times each 30 minutes～45 minutes, leaves standstill 2 extracting solution merging.
9. according to the preparation method of the Chinese medicine preparation of the described treatment femur head necrosis of claim 7, it is characterized in that, among the described step b, described residue component is put into water, the consumption of described water is 10 times of amounts of described residue component weight portion sum, heating and refluxing extraction 2 times each 30 minutes～45 minutes, leaves standstill 2 extracting solution merging.
10. according to the preparation method of the Chinese medicine preparation of the described treatment femur head necrosis of claim 7, it is characterized in that, among the described step c, extracting solution after described two kinds left standstill merges, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, and sucking filtration is when the relative density of filtrate is 20 ℃ 1.06; After above-mentioned filtrate is the macroporous adsorptive resins absorption of 10L through volume, with the deionized water or the distilled water eluting of 10 times of resin column volumes, 95% ethanol elution of 5 times of resin column volumes of reuse, collect ethanol elution, remove solvent, obtain medicated powder, incapsulate and be made as capsule.
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Cited By (7)
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| CN101926905A (en) * | 2010-07-14 | 2010-12-29 | 陈卫衡 | Application of Chinese medicinal composition containing components for invigorating spleen and reducing phlegm in preparing medicine for treating early and medium stage femoral head necrosis |
| CN101926906A (en) * | 2010-07-14 | 2010-12-29 | 陈卫衡 | Chinese medicinal composition for treating early and medium femoral necrosis |
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| CN1958027B (en) * | 2005-10-08 | 2011-01-26 | 刘国飞 | Composition of Chinese traditional medicine for treating necrosis of femoral head, and preparation method |
| CN101428096B (en) * | 2007-11-06 | 2011-01-26 | 魏敬成 | Chinese medicinal composition for treating femoral head necrosis and preparation method thereof |
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| CN101926905A (en) * | 2010-07-14 | 2010-12-29 | 陈卫衡 | Application of Chinese medicinal composition containing components for invigorating spleen and reducing phlegm in preparing medicine for treating early and medium stage femoral head necrosis |
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| CN101926906B (en) * | 2010-07-14 | 2011-09-07 | 陈卫衡 | Chinese medicinal composition for treating early and medium femoral necrosis |
| CN101926905B (en) * | 2010-07-14 | 2011-09-14 | 陈卫衡 | Application of Chinese medicinal composition containing components for invigorating spleen and reducing phlegm in preparing medicine for treating early and medium stage femoral head necrosis |
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| CN103028051B (en) * | 2011-09-29 | 2014-09-10 | 马甲秀 | Kidney nourishing, blood circulation stimulating and pyralysis removing pill |
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| CN102836273B (en) * | 2012-09-04 | 2014-02-19 | 卢华 | Medicament for treating osteonecrosis |
| CN104095985A (en) * | 2014-07-31 | 2014-10-15 | 蚌埠火鹤制药有限公司 | Chinese medicinal formula for treating idiopathic femoral head necrosis |
| CN104857297A (en) * | 2015-04-28 | 2015-08-26 | 汤玮 | Chinese medicine for curing children caput femoris epiphysis ischemic necrosis |
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