CN101524469B - Chinese herbal medicine compound preparation for treating congestive heart failure and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese herbal medicine compound preparation for treating congestive heart failure and a preparation method thereof. The Chinese herbal medicine compound preparation comprises various components according to the parts by weight: 10-30 parts of ginseng, 10-30 parts of the root of red-rooted salvia, 10-30 parts of safflower, 10-30 parts of rhizoma cyperi, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of angelica, 10-30 parts of peach kernel, 10-30 parts of red paeonia, 10-30 parts of schisandra chinensis, 10-30 parts of pseudo-ginseng, 10-30 parts of cinnamon, 10-15 parts of monkshood, 10-30 parts of ophiopogon root, 10-30 parts of milk weteh, 10-30 parts of asarum, 10-30 parts of notopterygium root, 10-30 parts of spatholobus stem, 10-30 parts of rhizoma atractylodis, 10-15 parts of toad coat, 10-30 parts of folium ginkgo, and 10-30 parts of the rhizome of chuanxiong. The Chinese herbal medicine compound preparation can inhibit platelet aggregation and thrombosis, improves microcirculation, increases coronary blood flow, has the function of cardiac stimulant, can increase cardiac and cardiac index, has the efficacy of dilating blood vessels and depressurization, and can be effectively used for treating patients with clinical congestive heart failure.

Description

A kind of compound Chinese medicinal preparation of treating congestive heart failure and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of compound Chinese medicinal preparation of treating congestive heart failure and preparation method thereof.

Background technology

Congestive heart failure (congestive heart failure; CHF) pathophysiological change is a very complex dynamic process, comprises nerve, the synthetic increase of compensatory variation, sarcostyle forfeiture, cytoskeleton arrangement disorder, apoptosis of cardiac muscle, collagen of body fluid adjusting factor, myocyte Ca ²⁺The variations that the change of the disorder of stable state, cell-membrane receptor density, the activation of cytokine, cell information are transmitted etc., and the reduction of performance of contracting of relaxing of the myocardial structural reconstruct that causes of a series of thus variation and cardiac muscle finally cause heart failure.In this process, almost variation has all appearred in each metabolism link of cell, and measuring any index possibly all have positive findings.Further investigation then needs from this numerous and diverse phenomenon, to find and heart failure generation, development factor in close relations.

Congestive heart failure belongs to categories such as Chinese medicine " the syndrome of dyspnea ", " thoracic obstruction ", " cardiopalmus ", and " element is asked the numbness opinion " said: " obstruction of heart-QI person, arteries and veins is obstructed, and tired then severe palpitation is gone up gas cruelly and is breathed heavily." it pants, has palpitation, weak, breathe hard, and moving then more so, belong to deficiency of vital energy performance; Uncomfortable in chest, chest pain, purplish tongue are levying of blood-stasis internal-depression; And this type patient course of disease is long, " prolonged illness must be empty ", " pathogen usually intruding into collateral in protracted disease ", so its main pathogenesis is deficiency of vital energy yang deficiency folder blood stasis, deficiency of vital energy yang deficiency is this, and blood stasis is mark; Sick position relates to lung, kidney at the heart.Along with perfusion intervention survival patient's increase more early behind aged tendency of population and the acute myocardial infarction, the heart failure number increases sharply.The patient that declines of U.S. over-65s people group center accounts for 6%～10%, and an investigation of China shows that patients with heart failure accounts for 3.8% of the internal medicine inpatient same period, and the control of heart failure faces a severe challenge.The America and Europe announces the chronic heart failure diagnosis guide in succession in recent years; Having formulated with angiotensin converting enzyme inhibitor (ACEI) and beta-blocker is the standard therapeutic strategy of foundation stone; But the untoward reaction of medicine has usually limited the use of medicine; The patient can not only judge therapeutic effect according to symptom again, " active drug " and " effective dose " individuation is promoted produced query.How to improve the effect of heart failure treatment, reduce the generation of untoward reaction, become the new problem that we face, based on this, we explore with theory of Chinese medical science, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs treatment congestive heart failure.

The general plan that the traditional Chinese medical science is treated heart failure at present mainly contains " warming YANG, invigorate blood circulation, diuretic ", and the method for " heart tonifying, diuresis, expansion blood vessel " that this and doctor trained in Western medicine are traditional is to reach the same goal by different routes.Its therapeutic dose of Folium Digitalis Purpureae class cardiac tonic and toxic dose that the western medical treatment heart failure is used are very approaching, bring out arrhythmia easily; Catecholamines inotropic agent such as successive administrations such as dopamine, dobutamine can make myocardium beta receptor downward modulation, and adenyl cyclase loses quick and produces drug resistance; Pimobendane such as AMR, milrinone, the former is because of side effect such as infringement liver function, thrombocytopenia uses that be under an embargo, and latter's result of study is recently found this medicine reduction survival rate.Nearest external calcium ion sensitizer first first miaow pyrrole, methoxy miaow pyrrole, though meet the physiological conditions of cardiac muscle, first first miaow pyrrole uses because of its intensive toxicity is difficult to exploitation, methoxy miaow pyrrole still is in the preliminary study stage.Blood vessel dilating, heart tonifying, diuresis are the basic skills of western medical treatment heart failure, and Folium Digitalis Purpureae class cardiac tonic is prone to poison, and can not be used to merge the decreased heart rate patient; Diuretic then is prone to cause electrolyte disturbance.But the effect of Chinese medicine part replacement therapy heart failure Western medicine reduces the use of heart tonifying, diuresis Western medicine, thereby has avoided the generation of untoward reaction.

The clinical relevant symptoms of traditional Chinese medical science research heart failure often sporadically appears in each DAIWEN of the traditional Chinese medical science is offered with treatment side's medicine; Generally speaking; The main rule of treatment such as " blood circulation promoting and blood stasis dispelling, QI invigorating warming YANG, diuretic damp eliminatings " that adopts is often selected prescription plus-minus treatments such as SHENGMAI SAN, Zhen Wu Tang, Decoction for strengthening the Spleen-Yang, Brassicaceae Chinese jujube Lung Soup for use.And the research of single positive inotropic Chinese medicine; Start from modern age; Main medicine comprises heart tonifying glycoside such as Herba Adonidis, Herba Convallariae, periploca sepium, Rohdea japonica Roth, Semen Lepidii (Semen Descurainiae), Venenum Bufonis, and two kinds of non-heart tonifying glycoside such as Radix Ginseng, Radix Aconiti Lateralis Preparata, the Radix Astragali, Radix Ophiopogonis, Fructus Aurantii Immaturus, Rhizoma Zingiberis Recens, Cortex Cinnamomi.But the clinical efficacy of middle hospital medicine is not obtained significant breakthrough, especially to the treatment of severe and obstinate heart failure, fails to obtain leading position, only as auxiliary therapy, can't compete with Western medicine.And aspect observation index, because lack of uniform property has seriously restricted the development of Chinese medicine heart failure.

Look back TCM Document owing to be confined to the understanding of traditional etiology and pathogenesis, so Therapeutic Method except that warming YANG, invigorate blood circulation, the diuretic; Also have methods such as eliminating the pathogens from the lung, yin nourishing, QI invigorating; Improve myocardial contraction though result of study has also proved, improve effects such as symptom, do not bring breakthrough.At present, heart failure treatment should only not be confined to correct abnormal hemodynamics and relief of symptoms, also should take into account activated intervention of neuroendocrine and intervention that ventricle is reinvented.Along with the change of modern medicine, must do further thinking and research to some ideas and the measure of Chinese traditional treatment heart failure to heart failure Pathophysiology understanding and medical idea.We in conjunction with the development trend of modern medicine to heart failure pathophysiological mechanism understanding and medical idea, think that the congestive heart failure course of disease is longer through long-term clinical observation; Protracted course of disease; Normal deficiency of YANG affecting YIN, deficiency of YIN affecting YANG causes deficiency of both YIN and YANG; The state of an illness is complicated, performances such as the visible deficiency of vital energy of pathogeny, yang deficiency, the deficiency of YIN, blood stasis, malicious heresy.On this basis, draft that heart failure treatment is supporing yang with tonifying YIN, QI invigorating detoxifcation, activating blood and promoting diuresis be rule of treatment, prescription is used for clinical, has obtained good efficacy.

Summary of the invention

Technical problem to be solved by this invention is, a kind of compound Chinese medicinal preparation of treating congestive heart failure and preparation method thereof is provided, and remains in many deficiencies to the medicine of present control chronic heart failure; Like western medical treatment is main with chemotherapy still; Treatment cycle is long, and side effect is big, and uncertain therapeutic efficacy is cut; And be difficult for adhering to that traditional Chinese medical science traditional therapy does not have special treatment chronic heart failure Chinese medicine to come out yet.

For solving the problems of the technologies described above, the present invention provides a kind of compound Chinese medicinal preparation of treating congestive heart failure, and the ratio of weight and number of various components is: 10～30 parts of Radix Ginsengs, 10～30 parts of Radix Salviae Miltiorrhizaes, 10～30 parts on Flos Carthami; 10～30 parts of Rhizoma Cyperis, 10～30 parts of the Rhizoma Atractylodis Macrocephalaes, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts in Semen Persicae, 10～30 parts of Radix Paeoniae Rubra; 10～30 parts of Fructus Schisandrae Chinensis, 10～30 parts of Radix Notoginseng, 10～30 parts of Cortex Cinnamomis, 10～15 parts of Radix Aconiti Lateralis Preparatas, 10～30 parts of Radix Ophiopogonis; 10～30 parts of the Radixs Astragali, 10～30 parts of Herba Asaris, 10～30 parts of Rhizoma Et Radix Notopterygiis, 10～30 parts of Caulis Spatholobis; 10～30 parts of Rhizoma Atractylodis, 10～15 parts in toad clothing, 5～10 parts of Folium Ginkgos, 10～30 parts of Rhizoma Chuanxiongs.

The compound Chinese medicinal preparation of said treatment congestive heart failure, the ratio of weight and number of various components can be preferably: 10～15 parts of Radix Ginsengs, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts on Flos Carthami, 10～15 parts of Rhizoma Cyperis; 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts in Semen Persicae, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of Fructus Schisandrae Chinensis; 10～15 parts of Radix Notoginseng, 10～20 parts of Cortex Cinnamomis, 10～15 parts of Radix Aconiti Lateralis Preparatas, 10～20 parts of Radix Ophiopogonis; 10～20 parts of the Radixs Astragali, 10～20 parts of Herba Asaris, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～20 parts of Caulis Spatholobis; 10～20 parts of Rhizoma Atractylodis, 10～15 parts in toad clothing, 5～10 parts of Folium Ginkgos, 10～20 parts of Rhizoma Chuanxiongs.

The compound Chinese medicinal preparation of said treatment congestive heart failure, the ratio of weight and number of various components also can be preferably: 10～20 parts of Radix Ginsengs, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts on Flos Carthami, 10～20 parts of Rhizoma Cyperis; 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts in Semen Persicae, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Fructus Schisandrae Chinensis; 10～20 parts of Radix Notoginseng, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Radix Aconiti Lateralis Preparatas, 10～15 parts of Radix Ophiopogonis; 10～15 parts of the Radixs Astragali, 10～15 parts of Herba Asaris, 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Caulis Spatholobis; 10～15 parts of Rhizoma Atractylodis, 10～15 parts in toad clothing, 5～10 parts of Folium Ginkgos, 10～15 parts of Rhizoma Chuanxiongs.

The compound Chinese medicinal preparation of said treatment congestive heart failure, the ratio of weight and number of various components also can be preferably: 15～25 parts of Radix Ginsengs, 15～25 parts of Radix Salviae Miltiorrhizaes, 15～25 parts on Flos Carthami, 15～25 parts of Rhizoma Cyperis; 15～25 parts of the Rhizoma Atractylodis Macrocephalaes, 15～25 parts of Radix Angelicae Sinensis, 15～25 parts in Semen Persicae, 15～25 parts of Radix Paeoniae Rubra, 15～25 parts of Fructus Schisandrae Chinensis; 15～25 parts of Radix Notoginseng, 15～25 parts of Cortex Cinnamomis, 10～15 parts of Radix Aconiti Lateralis Preparatas, 15～25 parts of Radix Ophiopogonis; 15～25 parts of the Radixs Astragali, 15～25 parts of Herba Asaris, 15～25 parts of Rhizoma Et Radix Notopterygiis, 15～25 parts of Caulis Spatholobis; 15～25 parts of Rhizoma Atractylodis, 10～15 parts in toad clothing, 5～10 parts of Folium Ginkgos, 15～25 parts of Rhizoma Chuanxiongs.

The compound Chinese medicinal preparation of said treatment congestive heart failure, in the time of can frying in shallow oil decoction in use and take, 1 dose of every day, decocting is obeyed at twice, and per 30 days is a course of treatment.

The compound Chinese medicinal preparation of said treatment congestive heart failure, said dosage form can be honey refining pill, hydration pill, capsule, oral liquid, tablet, drop pill or syrup.

For solving the problems of the technologies described above, the invention provides a kind of method for preparing of treating the compound Chinese medicinal preparation of congestive heart failure, when the dosage form of said compound Chinese medicinal preparation was honey refining pill, its preparation method may further comprise the steps:

Toad clothing, Radix Aconiti Lateralis Preparata and Folium Ginkgo are immersed 95% soak with ethanol three times, and each soak time was respectively 2 hours, 1 hour, 1 hour; Each 80～85 ℃ of heat in back of soaking are extracted, and alleviate toxicity; The ratio of weight and number of used ethanol and toad clothing, Radix Aconiti Lateralis Preparata and Folium Ginkgo is respectively: for the first time 10 times of amounts, the second time 6 times of amounts, 6 times of amounts for the third time; Merge three times ethanol extract, be concentrated into relative density and be 1.06 concentrated solution, stand for standby use; All the other components were soaked 30 minutes to 1 hour, and heated and boiled 30 minutes is filtered filtrate for later use; Filtering residue adds water, and heating was boiled 30 minutes for the second time, refiltered filtrate for later use; Filtering residue adds water again, and heated and boiled is 40 minutes for the third time, filters; Three filtratings are lumped together with the aforementioned liquid that leaves standstill, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, dries postcooling, and mixing with Mel is twisted into slice; With every 5g is ball wax seal packing.

For solving the problems of the technologies described above, the present invention also provides a kind of method for preparing of treating the compound Chinese medicinal preparation of congestive heart failure, when the dosage form of said compound Chinese medicinal preparation is capsule; Its preparation method may further comprise the steps: said component is added 10 times of amounts of weight ethanol, heating and refluxing extraction 3 times, each 2 hours; 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL; Behind the sucking filtration, when the relative density of filtrating is 20 ℃ 1.08; Said filtrate flow is the macroporous adsorptive resins of 10L through volume; Use the deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, 95% ethanol elution of 5 times of resin column volumes of reuse is collected ethanol elution; Remove alcohol solvent; Obtain component medicated powder, incapsulate and be made as capsule, every capsules dress 0.4g.

For solving the problems of the technologies described above; The present invention provides a kind of method for preparing of treating the compound Chinese medicinal preparation of congestive heart failure again; When the dosage form of said compound Chinese medicinal preparation is oral liquid; Its preparation method may further comprise the steps: with the toad clothing, and the soak with ethanol of Radix Aconiti Lateralis Preparata and Folium Ginkgo immersion 95% three times, each soak time was respectively 2 hours, 1 hour, 1 hour; Each 80～85 ℃ of heat in back of soaking are extracted, and alleviate toxicity; Used ethanol and toad clothing, the ratio of weight and number of Radix Aconiti Lateralis Preparata and Folium Ginkgo is respectively: for the first time 10 times of amounts, the second time 6 times of amounts, 6 times of amounts for the third time; Merge three times ethanol extract, be concentrated into relative density and be 1.06 concentrated solution, stand for standby use; The residual drug chopping is joined in the multi-function extractor, and the adding ratio of weight and number is that 3000 parts water logging was steeped 30～40 minutes, decocts after 1.5 hours, and decoction liquor is subsequent use for the first time in taking-up; Medicinal residues adding ratio of weight and number is after 3000 parts decocting boils 1 hour, to take out decoction liquor for the second time, twice decoction liquor is merged filter; It is 1000 parts solution that filtrate decompression is concentrated into ratio of weight and number, staticly settles 24～36 hours, draws supernatant; Merge concentrated solution twice, being concentrated into relative density is 1.04-1.05, the 14000-16000rps high speed centrifugation; Getting supernatant concentration to relative density is 1.10-1.14, spray drying or add a small amount of dextrin spray drying and get extract powder; Add syrup and process oral liquid formulations.

Compared with prior art, the extract of the inventive method acquisition is convenient to the preparation of solid preparation.When extract of the present invention was prepared into solid preparation, usually extracting solution must the spray-dried extract powder that becomes, and granulate, thereby supplementary product consumption in the minimizing preparation reduces clinical taking dose again.If the sample liquid behind water extraction and the precipitate with ethanol is carried out spray drying, very easily sticking wall is difficult to obtain dried powder, and loss is very big, even obtain powder, because of hygroscopicity is very strong, also is difficult to process granule, makes troubles for the preparation of solid preparation.And the present invention through ultracentrifugal medicinal liquid because to remove impurity comparatively thorough, concentrate, after the spray drying, can obtain dry loose powdered, the back yield rate of granulating is high, can be suitable for large-scale production.

For solving the problems of the technologies described above, the present invention provides a kind of method for preparing of treating the compound Chinese medicinal preparation of congestive heart failure again, when the dosage form of said compound Chinese medicinal preparation is drop pill; Its preparation method may further comprise the steps: with Rhizoma Cyperi, and Rhizoma Et Radix Notopterygii, Herba Asari; Rhizoma Chuanxiong and Radix Notoginseng add the water that its weight sum 5-7 doubly measures, and put into multi-function extractor, keep air pressure at 0.04-0.06mPa; Decocted 2 hours, and extracted its water soluble ingredient; Repeat above-mentioned steps and extracted extracting liquid filtering 100 mesh sieves once more 1.5 hours; With the refining filtrating of adsorbent resin, use ethanol elution; It is 1.33-1.35 that eluent is evaporated to density, and wherein input air pressure is 0.04-0.06mPa, vacuum is-0.076～-0.088mPa, stand for standby use; All the other components add the water that its weight sum 5-7 doubly measures; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours, extracts its water soluble ingredient; Repeating above-mentioned steps extracted 1 hour once more; The filter extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate is to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitation liquid filters with 100 mesh sieves; Vacuum concentrated filtrate, admission pressure are 0.04-0.06mPa, and vacuum is 0.076-0.088mPa; The use sephadex chromatography is refining, uses ethanol elution; It is 1.33-1.35 that eluent is concentrated into density, leaves standstill; Get above-mentioned two kinds and leave standstill drop and go in the dimethicone to cool off, promptly get drop pill.

Drop pill machine technology parameter is following: the drip irrigation temperature keeps 85-95 ℃, and condensed fluid liquid paraffin temperature is lower than 8 ℃, and the water dropper internal diameter is 1.6mm, and the water dropper external diameter is 2.5mm, and water dropper is 15cm apart from the liquid paraffin surface distance; Centrifugal, rotating speed 800-1100rpm after 15 minutes, removes deparaffnize and gets final product.Be quick acting, drop pill of the present invention is made into to dissolve the piller of absorption in the Sublingual rapidly, and it can go into blood fast, and through cardiac muscle strengthens myocardial contraction rapidly, coronary blood flow increasing, and protecting myocardial cell improves cardiac function.

The Chinese medicine of treatment heart failure disease of the present invention invigorates vital energy and reinforce the heart, invigorating spleen for diuresis, blood circulation promoting and blood stasis dispelling, has the function of treating both the principal and secondary aspects of a disease, determined curative effect, and effect is remarkable.Compared with prior art religion, the present invention has clear superiority: the present invention is the pure injections of Chinese medicine that extracts, develops through modern medicine technology; Be beneficial to clinical extensive use.After research shows use, heart there is positive inotropic action, strengthens myocardial contraction, coronary blood flow increasing, protecting myocardial cell improves cardiac function.The hemodynamics that can obviously improve patients with heart failure is disorderly, improves cardiac function and left ventricle reconstruct; Its mechanism maybe be with to improve myocardial cell energy metabolism relevant.The present invention can effectively treat heart failure, and it is disorderly to correct hemodynamics, and the person's that improves the heart failure cardiac function improves short term effect; Can reverse depleted myocardium remodeling ventricle, thus the person's that improves the heart failure long-term prognosis; But also point out prolonged application and non-evident effect.

The specific embodiment

Heart failure is a kind of syndrome that various heart diseases cause cardiac insufficiency, and myocardial contraction descends and makes CO can not satisfy the needs of organism metabolism.In case heart failure occurs, most of patient just steps into the process of carrying out property deterioration.Therefore, heart failure is a kind of disease of serious harm human health, is one of old people's main causes of death.At present; Heart failure is the main cardiovascular disorder of the unique obvious rising in many countries and regions; Its main cause is an aged tendency of population and to the improvement of other main cardiovascular disease therapies effects, and coronary heart disease, hypertension and other patient's life spans are prolonged, and the chance that heart failure takes place increases.See that from foreign data western countries' coronary heart disease and hypertension incidence rate are more stable at present, variation tendency is in fair state, and the morbidity of heart failure is still obviously risen.China's coronary heart disease and hypertension incidence are still on the rise, and aged tendency of population trend and western countries are approximate.Therefore, can estimate that the morbidity of China's heart failure can be obvious rising trend, the people group center patient's number that declines constantly enlarges, and China cardiovascular diseases and senile disease prevention and control field are constituted new significant challenge, is necessary to strengthen this clinic study on the one hand.The edema that congestive heart failure causes belongs to traditional Chinese medical science edema edema due to YANG-insufficiency category, and its main cause is deficiency in origin, and is especially relevant with deficiency of heart-YANG and kidney-YANG.Swelling begins from lower limb, caves in and difficult rising, and claims YIN edema more.Heart deficiency of spleen-YANG, QI failing to transform into body fluid causes that part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels water is wet to spread unchecked, contain in the weak then aqueous vapor of kidney yang, below the edema waist more so.A little less than the deficiency of kidney-QI, impairment of purifying and descending function of the lung, functioning of bladder is unfavorable, and the urine amount is few, then is edema.Control suitable warming YANG to promote diuresis.Modern medicine is thought: the pathogeny of heart failure is comparatively complicated relevant with multiple factor, but myocardial contraction to weaken be common pathologic basis.

Western medical treatment congestive heart failure at present still owes desirable to some cases.Diuretic can make EI; The digitalis preparation individual variation is very big, the approaching even overlapping of toxic dose and therapeutic dose sometimes, or because of poor to the Folium Digitalis Purpureae toleration, cause poisoning easily or cause arrhythmia; The part vasodilation has certain side effect or unsuitable prolonged application.So we attempt to treat with Chinese medicine, congestive heart failure belongs to categories such as " edema ", " cardiopalmus ", " pained ", " asthma ", " pulmonary distension " of the traditional Chinese medical science respectively.The traditional Chinese medical science thinks that the pathogenesis crux point of congestive heart failure is a motive yang deficiency, stagnation of heart-blood.The sick position of gas yang deficiency has substantial connection mainly at the heart with internal organs such as lung, spleen, kidneys.Primary disease character belongs to deficiency in origin and excess in superficiality more.Deficiency of heart-YANG is this, and blood stasis, expectorant be turbid to be mark.Controlling should the QI invigorating warming YANG, blood circulation promoting and blood stasis dispelling is a method, applies in a flexible way according to the clinical practice situation, and primary disease is treated preferably.Heart failure is the card of deficiency in origin and excess in superficiality, loses void at this for the motive, is being designated as blood-vessel obstructive, fluid-retention stagnating in the interior." edema with the heart involved " disease of the similar traditional Chinese medical science, when mark was principal contradiction in fact, traditional Chinese medical science ancient books advocated to attach most importance to expelling fluid-retention mostly.Say like " Standards of Diagnosis and Treatment ": " if deficiency of heart-QI, kidney water icepros, contrary last and the person that stops the heart must roll over against gas, rush down its water, mend its sun.The quality of cardiac function is decided by the prosperity and decline of healthy energy, and in healthy energy was deposited, heresy can not be done.And it is artificially the highest with old age to fall ill, and mostly the sick of old age is empty, so pathogenesis is a deficiency in origin and excess in superficiality.Void comprises the void of the five internal organs, but is principal contradiction to have a guilty conscience, have a guilty conscience and must involve yang blood and qi, and gently then be deficiency of vital energy blood deficiency, heavy then yang blood and qi is all empty, very then faint and take off.Actually be " expectorant " and " stasis of blood ".As for empty and real who problem after whom earlier, general theory is thought has void earlier, after reality is just arranged.Having a guilty conscience, it is smooth to cause that QI and blood loses, gas and blood, and interdependence between yin and yang, qi as the commander of blood, blood being the mother of qi, and blood is capable with gas, and then blood is capable up to row, and gas is that initiatively blood is passive.The deficiency of vital energy is then given birth to expectorant, stops then disorder of QI movement in the phlegm-damp, the stagnation of QI hyperamization stasis of blood, and deficiency of vital energy blood is capable weak, the hyperamization stasis of blood again, blood stasis can react on gas, causes the stagnation of QI or the deficiency of vital energy further increases the weight of.Blockage of the cardiac vessels, the blood stasis of blood stagnate be its main diseases because of.

Chinese medicine is one of time-honored natural drug in the world, in the treatment of heart failure, has certain advantage and characteristic.Think that from the viewpoint of motherland's traditional medicine heart failure belongs to categories such as " palpitation with fear ", " palpitation with a distress feeling ", " the syndrome of dyspnea ", " obstruction of heart-QI " of Chinese medicine.In heart failure incidence and development process, the blood stasis due to qi deficiency water retention is its basic pathology mechanism, so the treatment heart failure ought be with QI invigorating for curing the disease originally, the mark of activating blood and promoting diuresis for curing the disease, giving consideration to both the incidental and fundamental are main.Yet aspect the traditional Chinese medicine of China, the very definite medicine of curative effect never, most of Chinese patent medicines all are on the basis of proved recipe, to carry out the flavour of a drug plus-minus, and combine the treatment measure of doctor trained in Western medicine.Both do not carry out deep research, do not develop new Chinese medicine yet with unique curative effect to disease.According to Chinese medical discrimination characteristics such as " pathogen usually intruding into collateral in protracted disease, the double silt of prolonged illness, prolonged illness must be felt frustrated ", in conjunction with clinical practice for many years, people propose the viewpoint that " promoting blood circulation to remove obstruction in the collateral, QI invigorating activate yang " opinion is controlled coronary heart disease.We invent a kind of benefiting QI for activating blood circulation that has with this theory, disperse blood stasis and dredge collateral, the new drug of the effect of blood vessel dilating, excited heart, enhancing coronary blood flow and myocardial contraction.

Chronic heart failure is the last home to return to of various heart diseases, be difficult to obtain good efficacy with Western medicine merely, and side effect is big.Primary disease belongs to categories such as Chinese medicine " cardiopalmus ", " the syndrome of dyspnea ", " edema ", " phlegm retention ", and pathogenesis is a deficiency in origin and excess in superficiality, the heart, lung, spleen, renal function imbalance; Cardiopathia with the passing of time; Involve lung, spleen, kidney etc. and cause diseases caused by retention of fluid expectorant and give birth in turbid, on insult cardiopulmonary and cause and breathe heavily, excessive skin and be swollen.Treatment focuses on and sets upright, invigorates blood circulation, diuretic.Radix Angelicae Sinensis invigorating the spleen and replenishing QI in the side, spermatogenesis nourishes blood; Radix Astragali tonifying Qi and lifting yang, the diuretic detumescent; Flos Carthami, Radix Salviae Miltiorrhizae and pseudo-ginseng blood-circulation-invigovating blood stasis dispelling; The Cortex Cinnamomi warming the meridian for promoting the flow of YANG QI; Rhizoma Atractylodis Macrocephalae promoting the circulation of QI the chest stuffiness relieving; The tangible coronary dilating of ginsenoside's tool, heart tonifying, reinforcement myocardial contraction, increase cardiac output, reduction myocardial oxygen consumption, reduction blood viscosity and peripheral vascular resistance effect; Simultaneously can reduce and eliminate oxygen-derived free radicals; Thereby the protection cardiac muscle is avoided ischemic injuries, invigorating the heart and spleen.All medicines share, and play altogether that spleen reinforcing is nourished heart, the merit of promoting the circulation of QI to induce diuresis, blood circulation promoting and blood stasis dispelling.

Pharmacological research shows that the Radix Astragali has positive inotropic action, contains glucose aldehydic acid, choline etc., can expand peripheral blood vessel, brings high blood pressure down, and strengthens myocardial contractility, improves cardiac output, can suppress the acid of platelet di-phosphate ester simultaneously, microcirculation improvement; But Radix Angelicae Sinensis, Flos Carthami, Radix Salviae Miltiorrhizae decreased heart rate increase coronary flow, and resisting myocardial ischemia strengthens myocardial contraction; But toad clothing arrhythmia reduces heart rate, significantly reduces the arterial pressure peak value; Rhizoma Chuanxiong, the calm diuresis of ability Radix Ophiopogonis, blood vessel dilating improves coronary circulation.Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Semen Persicae, Flos Carthami, Radix Salviae Miltiorrhizae are the article of activating blood circulation and dissipating phlegm, to reach the effect of blood circulation promoting and blood stasis dispelling, regulating qi and dredging collateral.But the general medical history of the thoracic obstruction patient normal simulataneous insufficiency and excessive of length is to suffer from, and is so-called empty, not the void thanks to of exogenous QI, blood, yin, yang; Real is the stagnation of QI, turbid, the cold coagulation of expectorant often, so clinical need on essential drugs, with the card plus-minus, are executed flexibly and controlled.Research shows, patients with coronary heart disease shows as that the deficiency of vital energy, blood stasis, expectorant are turbid more, cold coagulation or the deficiency of YIN, the stagnation of QI etc., but is main symptom with the blood stasis due to qi deficiency.Simultaneously, many researchs confirm that after patients with coronary heart disease was taken benefiting QI for activating blood circulation Chinese medicine, symptom improved, and cardiac function significantly improves.Radix Aconiti Lateralis Preparata, toad clothing activating blood circulation to dissipate blood stasis and dredge the collateral in the BENTONG heart side; The Radix Astragali, Caulis Spatholobi replenishing qi and promoting blood flow, the temperature gas that activates yang is to strengthen the merit of promoting blood circulation to remove obstruction in the collateral; Fructus Schisandrae Chinensis, the Cortex Cinnamomi QI invigorating and body resistance strengthening is strengthened resistance.All medicines share and play the effect that promoting blood circulation to remove obstruction in the collateral, QI invigorating activate yang, giving consideration to both the incidental and fundamental altogether.Modern pharmacological research confirms, Radix Aconiti Lateralis Preparata, toad clothing ability anticoagulant and thrombosis, and microcirculation improvement increases coronary blood flow; The extract of the Radix Astragali has cardiotonic, can improve heart stroke and cardiac index, has effects such as blood vessel dilating, blood pressure lowering, microcirculation improvement simultaneously; The Rhizoma Atractylodis Macrocephalae, Herba Asari have blood vessel dilating, excited heart, strengthen the effect of coronary blood flow and myocardial contraction.

Radix Angelicae Sinensis: its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

The Radix Astragali is main with tonify deficiency, ability invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Chinese medicine astragalus sweet in the mouth, and tepor is returned the lung spleen channel; But ascending YANG and invigorating QI, and " pearl sac " " the sweet Wen Chunyang of the Radix Astragali, it is with having five: mend all empty deficiencies, one also; Benefit vigour, two also; Strong taste, three also; Go flesh heat, four also; The hemopoietic of invigorating blood circulation, five also ".Modern pharmacological research is found: the Radix Astragali and effective ingredient astragaloside thereof and α-tyrosine have blood vessel dilating, reduce Peripheral resistance, thereby lightening heart load reduces myocardial oxygen consumption.The Radix Astragali can also improve the ability of myocardial cell anti-hypoxia " oxygen supply again " damage; Alleviate the damage of myocardial cells degree, keep the myocardial cell function of beating, improve myocardial cell energy metabolism protection cell ultrastructure; Improve SOD activity in the cell, strengthen the oxygen-derived free radicals ability of removing.Modern study is found: astragalin has positive inotropic action, has dose-effect relationship, and with Radix Astragali crude drug in calcium ion concentration irrelevant; And confirm that astragalin IV is its effective ingredient, and it can make, and cAMP raises in the myocardial cell, activates the protein kinase of dependency ATP, makes the calciphorin phosphorylation, and flow of calcium ions increases; CAMP raises in the cell simultaneously, promotes the sarcoplasmic reticulum calcium ion to discharge, and strengthens thereby myocardial cell excitement-contraction Rhizoma Nelumbinis is joined.The Radix Astragali includes and multiple antibiotic effective ingredient, and the ability enhancing body's immunological function, therefore can also be used to prevent the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " Radix Astragali is can tonifying five ZANG-organs all empty, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.

Radix Aconiti Lateralis Preparata is hot, sweet, big heat; Poisonous.GUIXIN, kidney, spleen channel.Have recuperating depleted YANG and rescuing the patient from collapse, it is supporing yang to mend fire, by the effect of wind-cold damp pathogen.Cure mainly the YANG-depletion collapse, the cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, arthralgia due to cold-dampnes etc." book on Chinese herbal medicine converges and says " cloud: " YIN-cold looses for Radix Aconiti Lateralis Preparata, recuperating depleted YANG gas.The time of all genus yang deficiency negative electrodes, the heat syndrome person of lung kidney unit, clothes dead distinguished service arranged " modern experiment proof Radix Aconiti Lateralis Preparata can strengthen myocardial contraction, accelerates heart rate, increase cardiac output, increase myocardial oxygen consumption.Adopt Chinese medicine serum pharmacological research method; After observing oral Radix Aconiti Lateralis Preparata crude preparation by using, animal serum has obvious enhancing myocardial contraction and the effect of accelerating myocardial contraction speed, administration after 2 hours the effect of pastille serum reach the peak; Show and really close the heart tonifying composition in the Radix Aconiti Lateralis Preparata decocting liquid, and this composition is oral effectively.The Radix Aconiti Lateralis Preparata over administration can cause arrhythmia.The demethylcoclaurine that from Radix Aconiti Lateralis Preparata, extracts (DMC) is the cardiac stimulant main component of Radix Aconiti Lateralis Preparata, and methyl chloride dopamine, Salsolinol also have cardiotonic.The demethylcoclaurine positive inotropic action is remarkable, is reduced to 10 in concentration ^-9During g/ml, the Bufo siccus isolated heart is still had cardiotonic.The demethylcoclaurine positive inotropic action is dose-effect relationship, 10 ^-9-5 * 10 ^-8In the g/ml scope, can make heart shrinkage amplitude increase 22%-98%, CO increases 15%-80%.Anesthetized dog and Cavia porcellus intravenous drip demethylcoclaurine per minute 2 μ g/kg can make systole left ventricular pressure power (LVP) rise 12% and 58% respectively, and the maximum rate (dp/dt max) that left ventricular pressure power rises increases by 73% and 26% respectively.The intravenous drip pentobarbital sodium, or, all can form acute experiment DHF animal model with the perfusate perfusion, demethylcoclaurine can make the failure heart shrinkage amplitude recover normal.This shows that demethylcoclaurine is to exsomatizing and at systemic heart, normal and failure heart all has tangible cardiotonic.Research at present thinks that demethylcoclaurine is the beta receptor partial agonist, and its cardiotonic is relevant with excited beta receptor.

Semen Persicae is bitter, and is sweet, puts down the special medicine that closes for blood stasis blood.Bitter to let out stagnant blood, sweet with tissue regeneration promoting blood." medicineization justice ": Semen Persicae, bitter in the mouth can rush down heat in blood, and the body profit can be grown dryness of the intestine.If gross weight grinds many usefulness, walk Liver Channel, main broken blood-retention, water month by month; And pain all over, extremity wood numbness, left hemiplegia, left sufficient patient; Relax through the promoting the circulation of blood of invigorating blood circulation with it, the merit of eliminating blood stasis to promote regeneration of blood is arranged,, go into large intestine if few usefulness is mashed in peeling; Control blood depletion and just close, the dry dyschezia of blood with its make moist removing heat from blood and blood, has relieving accumulation of pathogens to lead to stagnant power.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.Its chemical constituent of Radix Salviae Miltiorrhizae mainly is divided into 2 types: one is fat-soluble TANSHINONES, and one is water solublity danshensu etc.No matter be clinical or the most scholars of experimentation have affirmed that Radix Salviae Miltiorrhizae has coronary artery dilator, improve myocardium anti-anoxia ability, the expansion peripheral blood vessel; Microcirculation improvement is regulated the reparation and the regeneration of tissue, activates fibrinolytic anticoagulant; Enhancing immunity, effect such as antibiotic grade.Especially it can improve myocardial contraction under the situation that does not influence oxygen consumption when core function badness, and decreased heart rate obviously improves cardiac function, and blood flow is quickened, and the capillary bed opening increases.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carry it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Flos Campsis, Caulis Spatholobi is for oral administration to be that the treatment blood stasis is not loose the good medicine that nourishing blood silt is invigorated blood circulation.

Flos Carthami is warm in nature, acrid in the mouth.Cure mainly the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy goes into the blood chamber, and delirium is gone mad; Or vexed interior the expanding of blood, the sudden syncope with rigidity is that all puerperal, non-Flos Carthami can not be decided at card as extremely.All friendship like the obstructed and cold and heat of amenorrhea done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollen burst uneasyly, is cards of disharmony between QI and blood all, and non-Flos Carthami can not be transferred." medicineization justice ": Flos Carthami, kind tonneau passages through which vital energy circulates is gas medicine in the blood, can rush down and can mend, and wonderful justice is respectively arranged.If many with three, four money, then too hot temperature is wandered away blood.With Lignum Sappan removing blood stasis blood, to close Cortex Cinnamomi and stimulate the menstrual flow and close, assistant is returned, Chinese herbaceous peony is controlled all over or the pricking caused by the stagnation of QI and blood of breast abdomen, and this its row is led and is invigorated blood circulation also.If use seven, eight fens less, with dispersing liver-energy, helping the sea of blood, the void of enriching blood greatly, this its transfer smooth and with blood also; If end with two, three minutes, go into the heart to join painstaking effort, dismiss heart channel pathogenic fire, make the blood mediation, this its nourishing and hemopoietic are also; The justice of component number, meagre.Modern experiment shows that Flos Carthami has tangible effect to cardiovascular system: suppress the heart effect 1.: Flos Carthami decoct low dose can make Bufo siccus isolated heart and rabbit in slightly excitement of systemic heart, makes heart beating strong, and amplitude strengthens; Heavy dose then has inhibitory action to heart, makes decreased heart rate, and myocardial contraction weakens, and SV reduces.2. the experimentation to CF shows: Flos Carthami water extract and Flos Carthami water soluble mixt-Carthamus yellow have the effect of coronary blood flow increasing and myocardial nutrition property blood flow; The coronary artery dilating of Flos Carthami ethanol extraction and the effect of coronary blood flow increasing are then not obvious or do not have an influence.3. the experimentation to expeirmental myocardial ischemia and myocardial infarction shows: cause on the animal model of expeirmental myocardial ischemia or myocardial infarction rabbit, rat, dog etc., Flos Carthami and preparation thereof all have antagonism in various degree.Flos Carthami can make the rat or the rabbit acute myocardial ischemia that cause because of pituitrin that obvious protective effect is arranged; Can make repeatedly of short duration blocking-up coronary flow cause the degree of anesthetized dog acute myocardial ischemia obviously to alleviate; Scope is dwindled; Decreased heart rate; And the edge in protection acute myocardial infarction district, district and dwindle infarction size and reduce the amplitude that the marginal zone ECG ST section is raised, thus improve the supply-demand relationship of ischemic myocardium oxygen.Thereby Flos Carthami have the hemodynamics of improving myocardial ischemia reperfusion injury and reaches the effect that protection cardiac muscle improves function because of containing safflower yellow.Safflower yellow have the effect that obvious coronary blood flow increasing improves blood supply of cardiac muscle.In addition, safflower yellow has the obvious suppression effect to endogenous and extrinsic coagulation, but significant prolongation prothrombin time and clotting time, and to many links of coagulation process such as platelet adhesion reaction, thrombosis and fibrin are crosslinked etc. has inhibitory action.

Rhizoma Cyperi gas is flat, and the little hardship of acrid in the mouth is little sweet.The resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast." detailed outline " carries: the cold epidemic disease of the seasonal epidemic pathogens that looses, and sharp three warmers are separated six kinds of stagnation-syndromes, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot; Abdominal distention, beriberi is ended trusted subordinate, limbs, head, order, tooth, all pains of ear, and ulcer sores is spitted blood; Hematochezia, hematuria, married woman's bleeding not during menses, month time is uncomfortable, tire all kinds of diseases and ailments in preceding puerperal.Rhizoma Cyperi has the good resolving depression effect of regulating the flow of vital energy, and is used for the breast side of body and the stomach abdominal distention and pain of depression of liver-QI.

The sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock.Be rare Chinese medicine, but give birth to have good hemostasia effect, significant hemopoietic function with hemostasia and dissipation blood stasis, reducing swelling and alleviating pain; Can tighten and improve the arteria coronaria microcirculation, Radix Notoginseng is used as medicine with a long history, acts on peculiarly being regarded as the treasured in the medicine by ancient Chinese medicine doctor, so the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) " is arranged." it is little sweet and bitter to distinguish the flavor of, quite seemingly the flavor of Radix Ginseng for Radix Notoginseng." " all canes are pounced on trauma, and the dripping person of blood stasis chews promptly ending of mashed net for catching birds or fish immediately, and bruise the person promptly dissipate.If when receiving cane, clothes one, two money earlier, then the blood centre of punch not should be obeyed it behind the cane especially, and obey also good puerperal.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of the cloudy blood system of fainting, so can control all disorders of blood "." book on Chinese herbal medicine is looked for the truth " record: " Radix Notoginseng, common people only know the function hemostasis and pain-relieving.Hardly realize bitterly and ache work that blood ends because of applying the blood that looses because of blood stasis.The bitter temperature of Radix Notoginseng abnormal smells from the patient can be in its blood stasis of blood systemization." Radix Notoginseng ability coronary blood flow increasing, decreased heart rate reduces myocardial oxygen consumption, increases myocardium oxygen-resistant ability, and microcirculation improvement is removed the effect of smooth muscle spasm.

Radix Paeoniae Rubra is bitter, is slightly cold.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.The Radix Paeoniae Rubra branch excess-heat that can purify the blood, dissipating blood stasis blood is detained.These article function and Cortex Moutan are close, so normal be usefulness with the Cortex Moutan mutual reinforcement between.But the effect of Cortex Moutan clearing away heat and cooling blood is preferable, and the branch excess-heat that can purify the blood can be controlled fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for the blood system excess-heat, is good at promoting blood circulation to remove blood stasis.

The Herba Asari acrid in the mouth, temperature is dispeled the wind, cold expelling, row water is had one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia." property of medicine opinion " carries: control cough with dyspnea, and aversion to wind, public attention, spasm of the extremities, the settling five organs six internal organs add courage, and peeling rheumatism ancient term for country school can end under the eye lacrimation induced by wind pathogen, makes eye bright, and opens in the heart to stagnate, and removes toothache, and main blood closes, married woman's blood drop lumbago.Herba Asari has heart tonifying, resisting myocardial ischemia, rising blood pressure.Isolated experiment shows that Herba Asari volatile oil has tangible excitation to rabbit, arteries and veins rat heart, shows as positive inotropic, the positivity frequency effect, and can increase coronary flow.To the experimental cardiogenic shock of dog, Herba Asari can improve effects such as its mean arterial pressure, left constant pressure peak value and crown blood sinus flow, and its action intensity is similar with dopamine, but it does not accelerate heart rate.

The Fructus Schisandrae Chinensis temperature; Sour, sweet; Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.Fruit is made Chinese medicine function supplementing QI for promoting the production of body fluid, the nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, is calmed the nerves, and can control diseases such as chronic cough dyspnea due to deficiency, the few xerostomia in Tianjin, seminal emission chronic diarrhea, forgetful insomnia.The pharmacological testing proof can be regulated central nervous system's excitement and process of inhibition, promotes body metabolism, regulates the secretion of gastric juice and bile, and hepatitis convalescent period transaminase rising person is had the reduction effect.

Sweet, the mildly bitter flavor of property Radix Ophiopogonis is slightly cold.GUIXIN, lung, stomach warp.Function with cure mainly YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Be used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Control dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation is quenched one's thirst, and hinder in calentura Tianjin, dry mouth and throat, constipation.These article are sweet cold clear and rich, the heat of the kind lung that clears away heart-fire and yin nourishing relieving restlessness, and holding concurrently can clear and rich gastrointestinal and quench the thirst and moisturize.Effect with anti-experimental character arrhythmia, increase coronary flow.

Rhizoma Atractylodis property is hot, bitter in the mouth, temperature.Return spleen, stomach, Liver Channel.Function cures mainly drying damp and strengthening spleen, and expelling wind and cold makes eye bright.Be used for distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Influence to cardiovascular system shows that Rhizoma Atractylodis have slight inhibitory action to the Bufo siccus heart, and Bufo siccus hind leg blood vessel is had slight dilating effect.The low dose of intravenous injection of Rhizoma Atractylodis extractum can make rabbits blood pressure slightly rise, and heavy dose then makes blood pressure drops.The pharmacological action that the drying damp and strengthening spleen effect of Rhizoma Atractylodis is relevant is adjustment gastrointestinal motility function, antiulcer, protects the liver.Antibacterial etc.The main effective ingredient of Rhizoma Atractylodis is to be the volatile oil of representative with sagittol and hinesol.Rhizoma Atractylodis are to the influence of blood glucose, and anti-hypoxia, maincenter inhibition, antitumor, the calcification of promotion skeleton reach the effects such as influence to cardiovascular system, then are the modern study progress of its pharmacological action.

Radix Ginseng sweet in the mouth, little hardship, tepor is returned spleen, kidney channel, kind strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves.Kind all diseases of the deficiency of vital energy and insomnia forgetfulness, severe palpitation, blood deficiency and yellow complexion, the sexual impotence cold womb controlled." book on Chinese herbal medicine is just " cloud: " Radix Ginseng deficiency of vital energy blood deficiency all can be mended, the deficiency of YANG QI person of exhausting, this can return in the township that has of nothing else; The cloudy blood person of collapsing that bursts, this energy barrier after breaking with.Not hot precisely because gas is strong, so the ability solid and gas; Precisely because sweet in the mouth and pure is so can enrich blood.So all void and generating heat, void and spontaneous perspiration is empty and dizzy, empty and sleepy, empty and be scared; Empty and lose heart, void and spermatorrhea, empty and let out profit, void and headache, empty and suffer from abdominal pain; Void and desire food is not transported, and void and sputum are stopped up and stagnated, and void and hemoptysis is spitted blood is empty and drench drop and just close, and is all must indispensable person.The desires to compare with QI and blood, and then the Radix Ginseng abnormal smells from the patient is quite light and to belong to positive person many, is the medicine of edema caused by disorder of QI." " book on Chinese herbal medicine converge with speech " " the ginseng qi-tonifying hemopoietic, the medicine that helps intensive culture god also.So vital qi is weak, the very brief deficiency of vital energy is mended it with this, and hollow like Rong Wei, that uses can control also; The palpitation with fear palpitation with a distress feeling, forgetful in a trance, with this peaceful it; Unit is refreshing not enough, and empty win is unable, trains it with this, falls into like middle weakness of QI, and that uses can rise also." the wherein tangible coronary dilating of ginsenoside's tool, heart tonifying, reinforcement myocardial contraction, increase cardiac output, reduction myocardial oxygen consumption, reduction blood viscosity and peripheral vascular resistance effect; can reduce and eliminate oxygen-derived free radicals simultaneously, thereby the protection cardiac muscle is avoided ischemic injuries.

The Cortex Cinnamomi extremely hot in nature, acrid in the mouth, sweet.Be that the benefit fire is supporing yang, let the fire back to its origin, dispersing cold for relieving pain, the good medicine of promoting blood circulation to restore menstrual flow.Be used for sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.Cure mainly insufficiency of kidney-YANG; Gate of vitality's fire aversion to cold and cold limbs; Soreness of the waist and knees; Impotence and seminal emission; Dysuria or frequency; The dyspnea with rapid and short breath of losing heart; The all cards of edema oliguria; Decline of the fire from the gate of life; Fire is Gui Yuan not; Floating YANG; Refusing yang; And heat in the upper and cold in the lower; The flushed complexion cold foot; Dizziness and tinnitus; Dispute is rotten broken; Spleen-kidney vacuity cold; Coldness and pain in the epigastrium; The decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain; Cold womb is infertile; The dysmenorrhea amenorrhea; The stasis of blood stagnated and suffered from abdominal pain puerperal; The carbuncle of yin nature multiple abscess; Or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus; Or do not hold back after bursting." not Lu " be carried it: main pained, side of body wind, hypochondriac pain, warm muscle is promoted blood circulation, end tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago is ended saliva, cough; Can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, and nothing is feared.

Rhizoma Chuanxiong is gone into liver, spleen, three warmers three warps.Function cures mainly activating QI to alleviate the depression, and the method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache and revolve dizzyly, the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." detailed outline " carries: " dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine is removed vascular smooth muscle (aortic article) spasm (epinephrine, potassium chloride cause).Can also expand coronary vasodilator, coronary blood flow increasing.The myocardial ischemia-anoxemia that the antagonism pituitrin causes.Alleviate the myocardial infarction lesion degree that the ligation arteria coronaria causes.

Folium Ginkgo is sweet, bitter, puckery, and is flat.GUIXIN, lung meridian.Function cures mainly astringes the lung, and relievings asthma blood circulation promoting and blood stasis dispelling, pain relieving.Be used for cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia, anticoagulant is solid, and certain probability improving memory is arranged.Though Folium Ginkgo ability blood circulation promoting, Prevention of Cardiovascular is sick, can not take other simultaneously and control cardiovascular drugs (for example aspirin).There have been 100,015,000 years on earth in Semen Ginkgo, and the length in its life-span occupies first of each plant, is called " plant living fossil " by scientist.The leaf of Semen Ginkgo contains the number of chemical composition can go into Chinese medicine, and the Chinese Academy of Sciences and lot of domestic and foreign medical expert discover in recent years: can extract the effective medicinal ingredient of kind more than 160 in the Folium Ginkgo.Wherein, flavone compound is 35 kinds; 17 seed amino acids and various trace elements.Can prevent and treat cardiovascular disease. prevent hypertension that the adult causes because of the vessel aging, apoplexy, diabetes etc.; Can make the adult especially keep the natural materials of normal cardiac output and normal nervous function period, make the people keep normal cell life cycle as far as possible person in middle and old age.

The toad clothing is the epidermis coating of Venenum Bufonis serosity, and Sun Simiao is claimed: " it is swollen except that disliking that toad is sloughed off (clothing), and god also ".The Li Shizhen (1518-1593 A.D.) Compendium of Material Medica is claimed: " the toad clothing is that it holds sufficient the essence of five ZANG-organs and six FU-organs gas, receives the China of world negative and positive precious, if one of obtain, all foul diseases do not have and do not heal ".The traditional Chinese medical science thinks that the toad clothing has removing toxic substances and promoting subsidence of swelling, pain relieving, wards off foul effect, is widely used in the treatment of sore and toxic, laryngopharynx swelling and pain etc.Modern study is thought: toad clothing master master contains toad clothing dienol chemical compound, comprises bufalin and toad clothing toxin, has heart tonifying, boosts, antiinflammatory action, and bufalin also has stronger anesthetic action.The scientific research personnel finds that the toad clothing also has multiple magical functions such as antitumor, antiviral, can be used for treating difficult miscellaneous diseases such as multiple malignant tumor, hepatitis, herpes zoster, hepatic ascites, nephropathy, cyclomastopathy, hysteromyoma recently.

The manufacturing process of the present invention's honey refining pill is: with toad clothing 500g, and the soak with ethanol of Radix Aconiti Lateralis Preparata 500g and Folium Ginkgo 100g leaf immersion 95% three times, each soak time was respectively 2 hours, 1 hour, 1 hour; Each 80～85 ℃ of heat in back of soaking are extracted, and alleviate toxicity; Used ethanol and toad clothing, the ratio of weight and number of Radix Aconiti Lateralis Preparata and Folium Ginkgo is respectively: for the first time 10 times of amounts, the second time 6 times of amounts, 6 times of amounts for the third time; Merge three times ethanol extract, be concentrated into relative density and be 1.06 concentrated solution, stand for standby use, with Radix Ginseng 3000g, Radix Salviae Miltiorrhizae 3000g, Flos Carthami 3000g; Rhizoma Cyperi 3000g, Rhizoma Atractylodis Macrocephalae 3000g, Radix Angelicae Sinensis 3000g, Semen Persicae 3000g, Radix Paeoniae Rubra 3000g; Fructus Schisandrae Chinensis 3000g, Radix Notoginseng 3000g, Cortex Cinnamomi 3000g, Radix Ophiopogonis 3000g, Radix Astragali 3000g; Herba Asari 3000g, Rhizoma Et Radix Notopterygii 3000g, Caulis Spatholobi 3000g, Rhizoma Atractylodis 3000g, Rhizoma Chuanxiong 3000g.Soak medical material 30 minutes to 1 hour, heated and boiled 30 minutes is filtered filtrate for later use; Filtering residue adds water, and heating was boiled 30 minutes for the second time, refiltered filtrate for later use; Filtering residue adds water again, and heated and boiled is 40 minutes for the third time, filters; Three filtratings are lumped together, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, and powdered being mixed in Mel of oven dry postcooling is twisted into slice; With every 5g is ball wax seal packing.

The manufacturing process of capsule of the present invention is: get Radix Ginseng 3000g, Radix Salviae Miltiorrhizae 3000g, Flos Carthami 3000g, Rhizoma Cyperi 3000g, Rhizoma Atractylodis Macrocephalae 3000g, Radix Angelicae Sinensis 3000g; Semen Persicae 3000g, Radix Paeoniae Rubra 3000g, Fructus Schisandrae Chinensis 3000g, Radix Notoginseng 3000g, Cortex Cinnamomi 3000g; Radix Ophiopogonis 3000g, Radix Astragali 3000g, Herba Asari 3000g, Rhizoma Et Radix Notopterygii 3000g, Caulis Spatholobi 3000g; Rhizoma Atractylodis 3000g, toad clothing 500g, Radix Aconiti Lateralis Preparata 500g, Folium Ginkgo 100g, Rhizoma Chuanxiong 3000g.Add 10 times of amount ethanol, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, the relative density of filtrating is about 1.08 (20 ℃); Above-mentioned filtrating is the macroporous adsorptive resins of 10L through volume, and with the deionized water or the distilled water eluting of 10 times of resin column volumes, 95% ethanol elution of 5 times of resin column volumes of reuse is collected ethanol elution, removes solvent, obtains the component medicine earlier; Incapsulate and be made as capsule, every capsules dress 0.4g.Can per 12 be a plate.

The manufacturing process of oral solutions of the present invention is: with toad clothing 500g, and the soak with ethanol of Radix Aconiti Lateralis Preparata 500g and Folium Ginkgo 100g leaf immersion 95% three times, each soak time was respectively 2 hours, 1 hour, 1 hour; Each 80～85 ℃ of heat in back of soaking are extracted, and alleviate toxicity; Used ethanol and toad clothing, the ratio of weight and number of Radix Aconiti Lateralis Preparata and Folium Ginkgo is respectively: for the first time 10 times of amounts, the second time 6 times of amounts, 6 times of amounts for the third time; Merge three times ethanol extract, be concentrated into relative density and be 1.06 concentrated solution, stand for standby use, with Radix Ginseng 3000g, Radix Salviae Miltiorrhizae 3000g, Flos Carthami 3000g; Rhizoma Cyperi 3000g, Rhizoma Atractylodis Macrocephalae 3000g, Radix Angelicae Sinensis 3000g, Semen Persicae 3000g, Radix Paeoniae Rubra 3000g; Fructus Schisandrae Chinensis 3000g, Radix Notoginseng 3000g, Cortex Cinnamomi 3000g, Radix Ophiopogonis 3000g, Radix Astragali 3000g; Herba Asari 3000g, Rhizoma Et Radix Notopterygii 3000g, Caulis Spatholobi 3000g, Rhizoma Atractylodis 3000g, Rhizoma Chuanxiong 3000g.Chopping joins in the multi-function extractor, and the adding ratio of weight and number is that 3000 parts water logging was steeped 30～40 minutes, decocts after 1.5 hours, and decoction liquor is subsequent use for the first time in taking-up; Medicinal residues adding ratio of weight and number is after 3000 parts decocting boils 1 hour, to take out decoction liquor for the second time, twice decoction liquor is merged filter; It is 1000 parts solution that filtrate decompression is concentrated into ratio of weight and number, staticly settles 24～36 hours, draws supernatant; Merge concentrated solution twice, being concentrated into relative density is 1.04-1.05, the 14000-16000rpm high speed centrifugation; Getting supernatant concentration to relative density is 1.10-1.14, spray drying or add a small amount of dextrin spray drying and get extract powder; Add pharmaceutic adjuvant (for example syrup) and process oral liquid formulations by the conventional formulation method.

The method for preparing of drop pill of the present invention may further comprise the steps: with Rhizoma Cyperi 1500g, and Herba Asari 1500g, Rhizoma Et Radix Notopterygii 1500g; Rhizoma Chuanxiong 1500g and Radix Notoginseng 1500g add the water that 5-7 doubly measures, and put into multi-function extractor, keep air pressure at 0.04-0.06mPa; Decocted 2 hours, and extracted its water soluble ingredient; Repeat above-mentioned steps and extracted extracting liquid filtering 100 mesh sieves once more 1.5 hours; With the refining filtrating of macroporous adsorbent resin, use ethanol elution; It is 1.33-1.35 that eluent is evaporated to density, and wherein input air pressure is 0.04-0.06mPa, vacuum is-0.076～-0.088mPa, stand for standby use; All the other medical material Radix Ginseng 1500g, Radix Salviae Miltiorrhizae 1500g, Flos Carthami 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Radix Angelicae Sinensis 1500g; Semen Persicae 1500g, Radix Paeoniae Rubra 1500g, Fructus Schisandrae Chinensis 1500g, Cortex Cinnamomi 1500g; Radix Ophiopogonis 1500g, Radix Astragali 1500g, Caulis Spatholobi 3000g, Rhizoma Atractylodis 1500g; Toad clothing 500g, Radix Aconiti Lateralis Preparata 500g, Folium Ginkgo 100g adds the water that 5-7 doubly measures; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours, extracts its water soluble ingredient; Repeat above-mentioned steps, extracted once more 1 hour; The filter extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate is to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitation liquid filters with 100 mesh sieves; Vacuum concentrated filtrate, admission pressure are 0.04-0.06mPa, and vacuum is 0.076-0.088mPa; The use sephadex chromatography is refining, uses ethanol elution; It is 1.33-1.35 that eluent is concentrated into density, leaves standstill, and splashes in the dimethicone and cools off, and promptly gets drop pill.

Drop pill machine technology parameter is following: the drip irrigation temperature keeps 85-95 ℃, and condensed fluid liquid paraffin temperature is lower than 8 ℃, and the water dropper internal diameter is 1.6mm, and the water dropper external diameter is 2.5mm, and water dropper is 15cm apart from the liquid paraffin surface distance; Centrifugal, rotating speed 800-1100rpm after 15 minutes, removes deparaffnize and gets final product.Be quick acting, drop pill of the present invention is made into to dissolve the piller of absorption in the Sublingual rapidly, and it can go into blood fast, through cardiac muscle.

Compound Chinese medicinal preparation pharmacodynamic study of the present invention:

1, after the insufficiency of heart-QI model mice was used compound Chinese medicinal preparation of the present invention, the anxiety that suspension is caused had obvious inhibitory action; Prolonged the length of one's sleep; Muscular tension increases, the time lengthening of standing; Adopting the water maze method to record memory increases; Hypoxia endurance time prolongs under the normal pressure; Insufficiency of heart-QI mice heart rate is recovered;

2, after normal mouse was used compound Chinese medicinal preparation of the present invention, the anxiety that forced swimming method and suspension method are caused had tangible sedation; Obviously prolonged the length of one's sleep of mice; Immunologic function is significantly improved, MNP phagocytic index and activate the phagocytic capacity are obviously increased, promote the formation of mice serum hemolysin.

3, the blood pressure to neuroendocrine type hypertension model rat has tangible reduction effect; Heart rate obviously recovers; The length of one's sleep, significant prolongation had the obvious synergistic effect with pentobarbital sodium; The test of water maze method is visible, and the memory of rat model is increased, and the time that in the labyrinth, stops obviously shortens; Visible with the head-breaking test, Chinese medicine composition of the present invention obviously prolongs the time of opening one's mouth behind the rat broken end.

Acute toxicity testing:

The oral maximum dosage-feeding of the mice of Chinese medicine composition of the present invention is 210g crude drug/kg, calculates by kg body weight, is equivalent to 1215 times of Coming-of-Age Day consumption 8.8g, presses body surface area and calculates, and is equivalent to 167 times; Intraperitoneal administration records its LD ₅₀Be 41.375 crude drugs/kg, its 95% credible 35.243～42.068g crude drug/kg that is limited to.Explain that compound Chinese medicinal preparation oral toxicity of the present invention is low, clinical practice is safer.

Long term toxicity test:

Compound Chinese medicinal preparation of the present invention to mice by 7.69,19.18 and the 43.21g crude drug/12 weeks of kg continuous use (1.0ml/100g body weight; Every day 2 times) and after 3 week of drug withdrawal; The result shows: compound Chinese medicinal preparation of the present invention does not all have obvious influence to indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat; The internal organs naked eyes do not find that difference changes and the histological examination result shows; After 12 weeks of medication and 3 weeks of drug withdrawal, each internal organs of rat all do not have obvious change.Explain that toxicity is little after compound Chinese medicinal preparation of the present invention is to the rat long-term prescription, also do not have abnormal response, application safety after the drug withdrawal.

Pharmacological effect

One, the present invention is to the influence of experimental heart failure domesticated dog arteria coronaria renal blood flow

1 material and method:

1.1 experiment material:

1.1.1 animal: 20 of healthy adult hybrid dogs, body weight 13.27 ± 0.59kg, male and female dual-purpose.

1.1.2 medicine: drop pill of the present invention; Pentobarbital sodium; Digoxin 0.25mg/ sheet; Heparin sodium injection; 0.9% sodium chloride injection.Above-mentioned experiment medicine all is mixed with equal-volume 3ml/kg with normal saline before experiment except that pentobarbital sodium, heparin, through duodenal administration.

1.2 experiment is divided into groups: laboratory animal is divided into four groups at random, 5 every group.A group: be the blank group, raise in the experiment with normal saline 3ml/kg; B group: low dose group of the present invention, 5g crude drug/kg; C group: high dose group of the present invention, 10g crude drug/kg; D group: positive controls, digoxin 100 μ g/kg.

1.3 experimental technique: laboratory animal is with pentobarbital sodium 30mg/kg intravenous anesthesia, and tracheal intubation connects the phrenoton and separates the right lateral thigh vein, connects the constant speed peristaltic pump, in order to the input pentobarbital sodium; Separate right common femoral artery, intubate is measured arteriotony BP; Left side the 4th intercostal is opened breast, exposes heart, cuts off pericardium, makees the pericardium bed, separates LCA and aorta, places the electromagnetic flowmeter probe respectively, measures CF CBF and cardiac output CO.Abdominal operation separates renal artery and places the electromagnetic flowmeter probe, measures renal artery blood flow amount KBF.Above-mentioned each item index synchronous recording is in polygraph.Implement abdominal operation, duodenal intubation is in order to giving institute's reagent thing.Intravenous injection heparin injection 125U/kg carries out heparinization, and after 30 minutes, record each item index is as with basic value before the drop pill of the present invention.Import 2% pentobarbital sodium through the peristaltic pump constant speed, input quantity is 0.2ml/minkg.Change maximum rate with left ventricular pressure and descend 70% as the heart failure index, reaching this value back adjustment pentobarbital sodium amount of feeding is 0.08ml/minkg, continues 15 minutes, makes left ventricular end diastolic presssure keep stable, index behind record each item heart failure, value before the medicine.Duodenum feeds institute's reagent thing.Respectively at 10,20,30,40,60,90,120,180 minutes record each item observation indexs behind the medicine.

1.4 statistical method adopts t check and χ ²Check.

2, result: two dose groups of drop pill of the present invention have the effect of increase CBF in various degree; After the medication 90 minutes; 10g crude drug/kg dose groups CBF 20.78 ± 8.06ml/min before the medicine increases to 39.61 ± 16.51ml/min; Increase by 81.16% ± 17.24%, with before the medication relatively and with relatively equal P＜0.05 of matched group, difference has statistical significance.Two dose groups of drop pill of the present invention are dissimilar to the CO influence.Two dose groups all can obviously increase KBF, significance statistical significance (P＜0.05) are all arranged with relatively reaching before the medicine with the matched group comparing difference.

3, this research confirms; Drop pill of the present invention can improve coronary artery and arteriorenal blood flow effectively; Not only can help the treatment of the heart failure that heart disease caused of a variety of causes, and the coronary artery that heart failure caused, the reduction of renal artery blood flow amount and the damage of renal function are had tangible curative effect.

Case 1: Huang, the man, 67 years old, coronary heart disease medical history 8 years, cardiopalmus, angina pectoris, arrhythmia, electrocardiogram shows: deficiency myocardial blood supply, ventricular premature contraction.Over 5 years, heart failure symptoms often appears, the time dyspnea is arranged, can not put down for sleeping in, two lower limb pitting edemas, blue-purplish tongue, deep-thready pulse knot generation.Clinical diagnosis: coronary heart disease, angina pectoris, arrhythmia, heart failure, cardiac function III level (NYHA).Use following prescription treatment: Radix Ginseng 10g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 15g, Rhizoma Cyperi 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Angelicae Sinensis 15g; Semen Persicae 15g, Radix Paeoniae Rubra 10g, Fructus Schisandrae Chinensis 15g, Radix Notoginseng 15g, Cortex Cinnamomi 20g; Radix Aconiti Lateralis Preparata 10g, Radix Ophiopogonis 15g, Radix Astragali 20g, Herba Asari 10g, Rhizoma Et Radix Notopterygii 10g; Caulis Spatholobi 15g, Rhizoma Atractylodis 15g, toad clothing 10g, Folium Ginkgo 5g, Rhizoma Chuanxiong 20g.Take decoction of the present invention, day clothes 2 times were taken medicine 10, and sx was taken medicine 30, and arrhythmia episode obviously alleviates, and continued medication and consolidated no above-mentioned uncomfortable clinical cure after 1 year in 6 months.

Embodiment 2: Feng, woman, 54 years old, coronary heart disease medical history 3 years, electrocardiogram: deficiency myocardial blood supply, atrial fibrillation.Clinical main suit: dyspnea is arranged when sitting quietly, can not put down for sleeping in, fatigue and weak, the white expectorant of coughing, two lower limb severe edema, blue-purplish tongue, deep-thready pulse are tied generation.Clinical diagnosis: coronary heart disease, angina pectoris, atrial fibrillation, heart failure, cardiac function III level (NYHA); Pulmonary infection.Take decoction of the present invention, use prescription as follows: Radix Ginseng 15g, Radix Salviae Miltiorrhizae 10g, Flos Carthami 15g, Rhizoma Cyperi 15g, Rhizoma Atractylodis Macrocephalae 10g; Radix Angelicae Sinensis 15g, Semen Persicae 20g, Radix Paeoniae Rubra 10g, Fructus Schisandrae Chinensis 10g, Radix Notoginseng 15g, Cortex Cinnamomi 20g; Radix Aconiti Lateralis Preparata 10g, Radix Ophiopogonis 15g, Radix Astragali 20g, Herba Asari 10g, Rhizoma Et Radix Notopterygii 10g; Caulis Spatholobi 20g, Rhizoma Atractylodis 15g, toad clothing 10g, Folium Ginkgo 5g, Rhizoma Chuanxiong 20g.Sx after 10 days, medication moon half a year is consolidated in the above-mentioned uncomfortable recurrence of not having after 2 months, reaches clinical recovery basically.

Embodiment 3: patient Shen, and the male 65 years old, has hypertension history, coronary heart disease medical history 3 years; Once observed through thromboembolism treatment because of suffering from acute myocardial infarction, left hospital after two months, still have uncomfortable in chest, breathe hard, discomfort such as weak, patient's long-term bed; Can not descend ground movable, the movable slightly back state of an illness increases the weight of, electrocardiogram prompting old heart infarction, and ST-T changes; Cardiac ultrasonic points out left chamber systolic and diastolic function to go down, and coronary angiography shows coronary atherosclerosis, and blood vessel is seriously narrow, Parallel PC I art.Chinese traditional treatment is changeed with heart failure, cardiac function III level (NYHA) in the back, adds the medicine pill of the present invention's preparation, uses prescription as follows:

Radix Ginseng 20g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 15g, Rhizoma Cyperi 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Angelicae Sinensis 20g, Semen Persicae 20g; Radix Paeoniae Rubra 10g, Fructus Schisandrae Chinensis 15g, Radix Notoginseng 15g, Cortex Cinnamomi 20g, Radix Aconiti Lateralis Preparata 10g, Radix Ophiopogonis 15g, Radix Astragali 15g; Herba Asari 10g, Rhizoma Et Radix Notopterygii 15g, Caulis Spatholobi 10g, Rhizoma Atractylodis 15g, toad clothing 10g, Folium Ginkgo 5g, Rhizoma Chuanxiong 20g.Processing honey refining pill takes.Take every day three times, each four, add the treatment of heartbeat health simultaneously, patient symptom is clearly better after 50 days.The ECG ST-T section is obviously improved after treating 5 months, and cardiac ultrasonic shows that left chamber contractile function improves unusually, continues to strengthen and takes half a year, recurrence so far after the drug withdrawal.

Embodiment 4: the patient Qin, and the women, 72 years old, angina pectoris history 5 years was with hypertension.Time sense cardiopalmus, pulse speeds, and pareordia is uncomfortable, fatigue and weak.Auxiliary examination: numeration of leukocyte raises, and electrocardio diagram ST-T changes, and goes to a doctor with coronary heart disease, arrhythmia, heart failure, cardiac function III level (NYHA).Add with following prescription: Radix Ginseng 20g, Radix Salviae Miltiorrhizae 20g, Flos Carthami 15g, Rhizoma Cyperi 10g, Rhizoma Atractylodis Macrocephalae 15g, Radix Angelicae Sinensis 20g; Semen Persicae 15g, Radix Paeoniae Rubra 10g, Fructus Schisandrae Chinensis 15g, Radix Notoginseng 15g, Cortex Cinnamomi 15g; Radix Aconiti Lateralis Preparata 10g, Radix Ophiopogonis 20g, Radix Astragali 15g, Herba Asari 15g, Rhizoma Et Radix Notopterygii 15g; Caulis Spatholobi 10g, Rhizoma Atractylodis 15g, toad clothing 10g, Folium Ginkgo 5g, Rhizoma Chuanxiong 20g.Take medicine pill prepared in accordance with the present invention, take every day three times, each four.Through trimestral treatment, the state of an illness tends towards stability, but have that slight cardiac dilatation, cardiac function go down, arrhythmia or electrocardiogram change, through 3 months treatment, patient's symptom further took a turn for the better again.

Clinical data

1.1 diagnosis and grade scale cardiac functional grading are carried out with reference to USA New York heart disease association (NYHA) cardiac functional grading scheme.

1.2 include in and the clinical coronary heart disease of clarifying a diagnosis of exclusion standard, hypertensive heart disease, pulmonary heart disease, expanding heart disease, rheumatic heart disease, cardiac function III～IV level patient are all included critical field in; Get rid of malignant tumor, pericarditis, acute myocardial infarction, liver and kidney failure, gestation and breast-feeding female patient.

1.3 the whole cases of physical data my inpatient of institute over nearly 3 years all through clinical symptoms, sign, the colored multispectral mensuration of reining in of heart, meets III～IV level by NYHA grade scale cardiac function, and whole cases are divided into treatment group and matched group at random.32 examples are organized in treatment, 50～75 years old age; Cardiac function III level 20 examples, cardiac function IV level 12 examples; Coronary heart disease 15 examples wherein, hypertensive heart disease 10 examples, pulmonary heart disease 5 examples, expanding heart disease 1 example, rheumatic heart disease 1 example.Matched group 32 examples, 55～75 years old age; Cardiac function III level 22 examples, cardiac function IV level 10 examples; Coronary heart disease 14 examples wherein, hypertensive heart disease 10 examples, pulmonary heart disease 6 examples; Expanding heart disease 1 example, rheumatic heart disease 1 example, two groups in age, the heart failure cause of disease, cardiac functional grading, protopathy etc. through statistical procedures; Difference not statistically significant (P＞0.05) has comparability.

2 Therapeutic Method

2.1 matched group comprises rest, low sodium diet, oxygen uptake, oral diuretics, standardization such as ACEI preparation treatment.The rapid heart rate person (110 times/min) interim intravenous injection cedilanid 0.4mg, furosemide 10-30mg, and give the cause of disease and the Supporting Therapy of suiting the medicine to the illness.Some cases gives digoxin 0.125～0.25mg, and every day 1 time is oral, a quiet in case of necessity sodium nitroprusside and dopamine treatment.

2.2 adding, the treatment group uses treatment by Chinese herbs of the present invention on the treatment of control group basis.1 dose of every day, decocting becomes 300mL, divides 2 times decoction being taken warmly.Two groups was 1 course of treatment with 4 weeks all.

2.3 itemized record clinical symptoms, sign and Minnesota quality of life investigation integration before and after two groups of treatments of observation index and method; Adopt the colored multispectral mensuration treatment changes of cardiac function of reining in of heart to comprise indexs such as SV, CO, CI, LVEF; Inspections such as the equal hepatic and renal function in treatment front and back, and observe untoward reaction.

2.4 the statistical method enumeration data adopts χ ²The t check is adopted in check, measurement data.

3 observation of curative effect

3.1 criterion of therapeutical effect: the criterion of therapeutical effect with reference to relevant chronic heart failure in the Ministry of Public Health " new Chinese medicine clinical research guideline " is ordered.Produce effects: heart failure basic controlling, cardiac function improve more than 2 grades, and symptom and sign and each item inspection obviously improve.Effectively: cardiac function improves 1 grade, but not as good as 2 grades, symptom and sign and each item inspection make moderate progress.Invalid: cardiac function improves not as good as 1 grade, even worsens.

3.2 therapeutic outcome

3.2.1 two groups of curative effects compare two groups of total effective rates relatively, difference has statistical significance (P＜0.05), and treatment group curative effect obviously is superior to matched group.(seeing table 1)

Table 1 liang group clinical efficacy relatively

Group	The example number	Produce effects	Effectively	Invalid	Total effective rate
						The treatment group	32	28(87.5％)	3(9.3％)	1(3.1％)	31(96.9％) *
Matched group	32	16(50％)	11(34.3％)	5(15.6％)	27(84.4％)

Annotate: two groups relatively ^*P＜0.05

3.2.2 before two groups of treatment back cardiac function of cardiac function comparison and the treatment improvement is arranged more all before and after two groups of treatments, difference all has statistical significance (P＜0.01); Treatment back treatment group cardiac function and matched group relatively improve significantly (P＜0.01).(seeing table 2)

Parameters of left ventricular function relatively before and after the table 2 liang group treatment

Annotate: with comparison before the treatment of control group, aP＞0.05; With comparison after the treatment of control group, bP＜0.01, with comparison before the group internal therapy, cP＜0.05.

3.2.3 two groups of untoward reaction relatively: occur in the treatment of control group process feeling sick, vomitting 5 examples, stop over is used digoxin, and treatment such as kalium replenishment back is alleviated, and obvious adverse reaction does not appear in the treatment group.

Claims (9)

1. a compound Chinese medicinal preparation of treating congestive heart failure is characterized in that, the ratio of weight and number of various crude drug is: 10～30 parts of Radix Ginsengs, 10～30 parts of Radix Salviae Miltiorrhizaes, 10～30 parts on Flos Carthami; 10～30 parts of Rhizoma Cyperis, 10～30 parts of the Rhizoma Atractylodis Macrocephalaes, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts in Semen Persicae, 10～30 parts of Radix Paeoniae Rubra; 10～30 parts of Fructus Schisandrae Chinensis, 10～30 parts of Radix Notoginseng, 10～30 parts of Cortex Cinnamomis, 10～15 parts of Radix Aconiti Lateralis Preparatas, 10～30 parts of Radix Ophiopogonis; 10～30 parts of the Radixs Astragali, 10～30 parts of Herba Asaris, 10～30 parts of Rhizoma Et Radix Notopterygiis, 10～30 parts of Caulis Spatholobis; 10～30 parts of Rhizoma Atractylodis, 10～15 parts in toad clothing, 5～10 parts of Folium Ginkgos, 10～30 parts of Rhizoma Chuanxiongs.

2. according to the compound Chinese medicinal preparation of the said treatment congestive heart failure of claim 1, it is characterized in that the ratio of weight and number of various crude drug is: 10～15 parts of Radix Ginsengs, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts on Flos Carthami; 10～15 parts of Rhizoma Cyperis, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts in Semen Persicae, 10～15 parts of Radix Paeoniae Rubra; 10～15 parts of Fructus Schisandrae Chinensis, 10～15 parts of Radix Notoginseng, 10～20 parts of Cortex Cinnamomis, 10～15 parts of Radix Aconiti Lateralis Preparatas, 10～20 parts of Radix Ophiopogonis; 10～20 parts of the Radixs Astragali, 10～20 parts of Herba Asaris, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～20 parts of Caulis Spatholobis; 10～20 parts of Rhizoma Atractylodis, 10～15 parts in toad clothing, 5～10 parts of Folium Ginkgos, 10～20 parts of Rhizoma Chuanxiongs.

3. according to the compound Chinese medicinal preparation of the said treatment congestive heart failure of claim 1, it is characterized in that the ratio of weight and number of various crude drug is: 10～20 parts of Radix Ginsengs, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts on Flos Carthami; 10～20 parts of Rhizoma Cyperis, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts in Semen Persicae, 10～20 parts of Radix Paeoniae Rubra; 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Radix Notoginseng, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Radix Aconiti Lateralis Preparatas, 10～15 parts of Radix Ophiopogonis; 10～15 parts of the Radixs Astragali, 10～15 parts of Herba Asaris, 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Caulis Spatholobis; 10～15 parts of Rhizoma Atractylodis, 10～15 parts in toad clothing, 5～10 parts of Folium Ginkgos, 10～15 parts of Rhizoma Chuanxiongs.

4. according to the compound Chinese medicinal preparation of the said treatment congestive heart failure of claim 1, it is characterized in that the ratio of weight and number of various crude drug is: 15～25 parts of Radix Ginsengs, 15～25 parts of Radix Salviae Miltiorrhizaes, 15～25 parts on Flos Carthami; 15～25 parts of Rhizoma Cyperis, 15～25 parts of the Rhizoma Atractylodis Macrocephalaes, 15～25 parts of Radix Angelicae Sinensis, 15～25 parts in Semen Persicae, 15～25 parts of Radix Paeoniae Rubra; 15～25 parts of Fructus Schisandrae Chinensis, 15～25 parts of Radix Notoginseng, 15～25 parts of Cortex Cinnamomis, 10～15 parts of Radix Aconiti Lateralis Preparatas, 15～25 parts of Radix Ophiopogonis; 15～25 parts of the Radixs Astragali, 15～25 parts of Herba Asaris, 15～25 parts of Rhizoma Et Radix Notopterygiis, 15～25 parts of Caulis Spatholobis; 15～25 parts of Rhizoma Atractylodis, 10～15 parts in toad clothing, 5～10 parts of Folium Ginkgos, 15～25 parts of Rhizoma Chuanxiongs.

5. according to the compound Chinese medicinal preparation of each said treatment congestive heart failure in the claim 1～4, it is characterized in that the dosage form of said compound Chinese medicinal preparation is: honey refining pill, hydration pill, capsule, oral liquid, tablet, drop pill or syrup.

6. the method for preparing like the compound Chinese medicinal preparation of each said treatment congestive heart failure in the claim 1～4 is characterized in that, the dosage form of said compound Chinese medicinal preparation is a honey refining pill, and its preparation method may further comprise the steps:

With the toad clothing, the soak with ethanol of Radix Aconiti Lateralis Preparata and Folium Ginkgo immersion 95% three times, each soak time was respectively 2 hours, 1 hour, 1 hour; Each 80～85 ℃ of heat in back of soaking are extracted; Used ethanol and toad clothing, the ratio of weight and number of Radix Aconiti Lateralis Preparata and Folium Ginkgo is respectively: for the first time 10 times of amounts, the second time 6 times of amounts, 6 times of amounts for the third time; Merge three times ethanol extract, be concentrated into relative density and be 1.06 concentrated solution, stand for standby use; All the other crude drug were soaked 30 minutes to 1 hour, and heated and boiled 30 minutes is filtered filtrate for later use; Filtering residue adds water, and heating was boiled 30 minutes for the second time, refiltered filtrate for later use; Filtering residue adds water again, and heated and boiled is 40 minutes for the third time, filters; Three filtratings are lumped together with the aforementioned liquid that leaves standstill, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, dries postcooling, and mixing with Mel is twisted into slice; With every 5g is ball wax seal packing.

7. the method for preparing like the compound Chinese medicinal preparation of each said treatment congestive heart failure in the claim 1～4 is characterized in that, the dosage form of said compound Chinese medicinal preparation is a capsule; Its preparation method may further comprise the steps: said crude drug is added 10 times of amounts of weight ethanol, heating and refluxing extraction 3 times, each 2 hours; 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL; Behind the sucking filtration, when the relative density of filtrating is 20 ℃ 1.08; Said filtrate flow is the macroporous adsorptive resins of 10L through volume; Use the deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, 95% ethanol elution of 5 times of resin column volumes of reuse is collected ethanol elution; Remove alcohol solvent; Obtain crude drug medicated powder, incapsulate and be made as capsule, every capsules dress 0.4g.

8. method for preparing like the compound Chinese medicinal preparation of each said treatment congestive heart failure in the claim 1～4; It is characterized in that; Said compound Chinese medicinal preparation dosage form is an oral liquid; Its preparation method may further comprise the steps: with the toad clothing, and the soak with ethanol of Radix Aconiti Lateralis Preparata and Folium Ginkgo immersion 95% three times, each soak time was respectively 2 hours, 1 hour, 1 hour; Each 80～85 ℃ of heat in back of soaking are extracted; Used ethanol and toad clothing, the ratio of weight and number of Radix Aconiti Lateralis Preparata and Folium Ginkgo is respectively: for the first time 10 times of amounts, the second time 6 times of amounts, 6 times of amounts for the third time; Merge three times ethanol extract, be concentrated into relative density and be 1.06 concentrated solution, stand for standby use; All the other crude drug choppings are joined in the multi-function extractor, and the adding ratio of weight and number is that 3000 parts water logging was steeped 30～40 minutes, decocts after 1.5 hours, and decoction liquor is subsequent use for the first time in taking-up; Medicinal residues adding ratio of weight and number is after 3000 parts decocting boils 1 hour, to take out decoction liquor for the second time, aforementioned twice decoction liquor is merged filter; It is 1000 parts solution that filtrate decompression is concentrated into ratio of weight and number; Staticly settled 24～36 hours, and drew supernatant, merge with the aforementioned liquid that leaves standstill; Be concentrated into 14000-16000rps high speed centrifugation behind the relative density 1.04-1.05; Get supernatant concentration to relative density 1.10-1.14, spray drying or adding dextrin spray drying get extract powder, add syrup and process oral liquid.

9. the method for preparing like the compound Chinese medicinal preparation of each said treatment congestive heart failure in the claim 1～4 is characterized in that, said compound Chinese medicinal preparation dosage form is a drop pill; Its preparation method may further comprise the steps: compare with Rhizoma Cyperi Rhizoma Et Radix Notopterygii, Herba Asari according to said raw material medicines in portions by weight number; Rhizoma Chuanxiong and Radix Notoginseng add the water that its weight sum 5-7 doubly measures; Put into multi-function extractor, keep air pressure to decoct 2 hours, extract its water soluble ingredient at 0.04-0.06mPa; Repeat above-mentioned steps and extracted extracting liquid filtering 100 mesh sieves once more 1.5 hours; With the refining filtrating of adsorbent resin back ethanol elution; Eluent is evaporated to density 1.33-1.35, and wherein input air pressure is 0.04-0.06mPa, and vacuum is-0.076～-0.088mPa, stand for standby use; All the other crude drug add the water that its weight sum 5-7 doubly measures; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours; Repeating above-mentioned steps extracted 1 hour once more; The filter extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate is to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitation liquid filters with 100 mesh sieves; Vacuum concentrated filtrate, admission pressure are 0.04-0.06mPa, and vacuum is 0.076-0.088mPa; The use sephadex chromatography is refining, uses ethanol elution; Eluent is concentrated into density 1.33-1.35, leaves standstill; Get above-mentioned two kinds leave standstill drop go into cool off in the dimethicone drop pill.