CN100574800C - A kind of Chinese patent medicine for the treatment of atherosclerosis of cardio-cerebral arteria and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of Chinese patent medicine for the treatment of atherosclerosis of cardio-cerebral arteria and preparation method thereof, it is with the Radix Astragali, Cortex Phellodendri, Fructus Crataegi, Rhizoma Zingiberis, Semen Coicis, Fructus Citri Sarcodactylis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Rhizoma Cyperi, Radix Puerariae, Bulbus Fritillariae Thunbergii, Fructus Aurantii, XIANGQU, Pericarpium Trichosanthis, Rhizoma Atractylodis, Radix Salviae Miltiorrhizae, Endothelium Corneum Gigeriae Galli, Radix Notoginseng, Radix Trichosanthis etc. are raw material, characteristic according to every flavor Chinese medicine, use boiling respectively, extract volatile oil, after handling, methods such as air-dry pulverizing prepare the medicine of gained in proportion, be used for cerebral atherosclerosis, dizziness headache due to the cerebral blood supply insufficiency, tinnitus, acute brain thromboembolism and cerebral infarction sequela; Coronary atherosclerosis, cardiopalmus, sensation of oppression over the chest with shortness of breath, angina pectoris due to the neural blood supply insufficiency of cardiac muscle and cardiac conduction, and common clinical such as arrhythmia, having clearing away heat and eliminating dampness, reduce phlegm turbidly, the fat that disappears is long-pending, the effect of promoting flow of QI and blood collateral dredging, reach relief of symptoms, the intra-arterial atheromatous plaque is removed in the arteriosclerotic evolution of slowing down, softening arteries, improve cardiac muscle and cardiac nerve blood supply, have the come off effect of formed myocardial infarction, cerebral embolism of dissolving atherosclerotic plaque ulceration simultaneously.

Description

A kind of Chinese patent medicine for the treatment of atherosclerosis of cardio-cerebral arteria and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of atherosclerosis of cardio-cerebral arteria.Specifically a kind of Chinese patent medicine the invention still further relates to the manufacture method of this medicine.

Background technology

Dizziness headache, tinnitus, acute brain thromboembolism and cerebral infarction sequela due to the cerebral atherosclerosis, cerebral blood supply insufficiency; Cardiopalmus, sensation of oppression over the chest with shortness of breath, angina pectoris due to the coronary atherosclerosis, the neural blood supply insufficiency of cardiac muscle and cardiac conduction, and arrhythmia etc. is a common clinical, the method of treatment primary disease is a lot of, and all with blood circulation promoting and blood stasis dispelling, circulation of qi promoting is main, though curative effect still can, late result is not good enough, drug withdrawal then easily the recurrence.

Summary of the invention

Purpose of the present invention just provides a kind of treatment cerebral atherosclerosis and crown atherosclerotic pure Chinese medicine.To because of cerebral arteriosclerosis, make cerebral blood supply insufficiency, cause dizziness, headache, tinnitus, cerebral thrombosis and sequela; Coronary atherosclerosis, cardiac muscle and cardiac nerve blood supply insufficiency, the cardiopalmus that causes, uncomfortable in chest, breathe hard, the treatment of angina pectoris, arrhythmia, myocardial infarction truly has curative effect.

Another object of the present invention provides the manufacture method of the Chinese patent medicine of this treatment atherosclerosis of cardio-cerebral arteria.

Solution of the present invention is based on the pathogeny to atherosclerosis of cardio-cerebral arteria, and screening has clearing away heat and eliminating dampness, the fat intestinal stasis relieving that disappears, and the natural plant of QI invigorating promoting flow of QI and blood function by the theory of Chinese medical science prescription, reaches therapeutic purposes.

Medicine of the present invention has following component to make: (consumption is a weight portion)

Radix Astragali 10-15 Cortex Phellodendri 1-2 Fructus Crataegi 10-15 Rhizoma Zingiberis 0.3-0.5

Semen Coicis 7-9 Fructus Citri Sarcodactylis 2-3 Radix Paeoniae Alba 4-6 Rhizoma Chuanxiong 2-3 Rhizoma Cyperi 1-2

Radix Puerariae 10-15 Bulbus Fritillariae Thunbergii 2-3 Fructus Aurantii 2-3 XIANGQU 7-8 Pericarpium Trichosanthis 2-3

Rhizoma Atractylodis 2-4 Radix Salviae Miltiorrhizae 10-15 Endothelium Corneum Gigeriae Galli 2-3 Radix Notoginseng 2-3 Radix Trichosanthis 2-4

Optimum weight of the present invention (part) proportioning is:

The Radix Astragali 10 Cortex Phellodendris 2 Fructus Crataegis 10 Rhizoma Zingiberiss 0.5 Semen Coicis 8 Fructus Citri Sarcodactylis 2 Radix Paeoniae Albas 6

Rhizoma Chuanxiong 2 Rhizoma Cyperis 2 Radix Puerariaes 10 Bulbus Fritillariae Thunbergiis 2 Fructus Aurantiis 2 XIANGQU 8 Pericarpium Trichosanthiss 2

Rhizoma Atractylodis 3 Radix Salviae Miltiorrhizaes 10 Endothelium Corneum Gigeriae Galli 3 Radix Notoginseng 2 Radix Trichosanthis 2

Above-mentioned each component is made medicine production method of the present invention is:

1. Endothelium Corneum Gigeriae Galli, Radix Notoginseng, Bulbus Fritillariae Thunbergii three flavors are ground into fine powder;

2. Rhizoma Atractylodis, Rhizoma Cyperi, Fructus Aurantii, Rhizoma Chuanxiong, the Rhizoma Zingiberis five tastes are extracted volatile oil;

3. with above-mentioned 2. in the institute medicinal residues that stay and the Radix Astragali, Cortex Phellodendri, Fructus Crataegi, Semen Coicis, Fructus Citri Sarcodactylis, the Radix Paeoniae Alba, Radix Puerariae, XIANGQU, Pericarpium Trichosanthis, Radix Salviae Miltiorrhizae, Radix Trichosanthis etc. ten decoct with water simply three times, 1.5 hours for the first time, second and third time each 1 hour filtered, merging filtrate, filtrate are condensed into the thick paste shape;

4. gained fine powder in concentrating thick paste, adding 1., mixing, drying, be ground into fine powder, dilute 2. middle gained volatile oil in dehydrated alcohol and 3: 1 ratios of volatile oil weight ratio with dehydrated alcohol, with above-mentioned fine powder mixing, airtight 2 hours, incapsulate or be pressed into bulk.

Characteristics of the present invention are clearing away heat and eliminating dampness Zhi Qiyin, the fat Zhi Qiben that disappears that reduces phlegm, and the promoting flow of QI and blood collateral dredging is controlled its mark.Atherosclerosis of cardio-cerebral arteria is because of long-term surfeit delicious food, and the ， Photo that seeks ease and comfort goes into and consumes loss of equilibrium, stagnates in the delicious food, change is given birth to damp and hot, and damp and hot friendship knot hinders the fortuneization of the spleen, causes the defeated cloth of spleen unusual, with the passing of time it is long-pending to form fat, stagnates in blood vessel, hinders QI-blood circulation, and forms cardiovascular and cerebrovascular disease; Fat is long-pending does not simultaneously remove, and gives birth to damp and hot source in becoming again, forms poor circulation.Therefore the Therapeutic Principle who adopts is:

1, clearing away heat and eliminating dampness is given birth in damp and hot, decocts into expectorant, gluing of phlegm and heat, it is long-pending to turn to fat, thus be earlier with the clearing away heat and eliminating dampness, remove pathogenic because of.

2, the fat that disappears that reduces phlegm, the body lactone is long-pending to be stagnated, and hinders the fortuneization and the defeated cloth of spleen, causes the QI-blood circulation obstacle; Can change again simultaneously and give birth to damp and hotly, form poor circulation, so the fat Zhi Qiben that disappears to reduce phlegm.

3, QI invigorating promoting flow of QI and blood stops in fat is long-pending, and venation is capable not smooth through fate, so with its mark of QI invigorating promoting flow of QI and blood acupuncture-stimulating treatment.

With Cortex Phellodendri, Rhizoma Atractylodis, Semen Coicis heat clearing away, removing dampness, dampness, give birth to damp and hot must removing in making among the side of the present invention, with remove pathogenic because of; Turbid with Fructus Trichosanthis shell, Bulbus Fritillariae Thunbergii, Radix Trichosanthis Qinghua expectorant, Disperse hepatic depression; Fructus Crataegi, XIANGQU, Endothelium Corneum Gigeriae Galli digestion fat are long-pending, make the fortuneization of spleen, defeated cloth function normal, amass in endovascular fat with removing pent-up, guarantee that QI-blood circulation is unobstructed; With promoting flow of QI and blood such as Radix Notoginseng, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Citri Sarcodactylis, Rhizoma Cyperi, Fructus Aurantiis, the capable then blood of gas is capable to be hindered to such an extent that remove to remove the resistance of expectorant blood stasis, to become silted up, and the body QI-blood circulation is tending towards normally, to improve the QI-blood circulation of cardiovascular and cerebrovascular vessel; With the Radix Astragali, Radix Paeoniae Alba benefiting QI and nourishing blood, qi being the governor of blood, blood being the material foundation of QI, gas is prosperous then agitates effectively, and blood works freely, to improve the heart and brain blood circulation; With the happy key of Radix Puerariae, logical brain network, thinking must be opened, and the brain network must be logical, and all diseases can be removed; Rouse oneself the spleen sun, be amusing with Rhizoma Zingiberis, prevent too bitter cold of Cortex Phellodendri simultaneously again, the merit of damage spleen sun.

Medicine of the present invention has the removing atherosclerotic plaque, and softening arteries improves heart and brain circulation effect.As the hypertension (increase based on systolic pressure, diastolic pressure is normal) due to the atherosclerosis, systolic pressure is descended, pulse pressure difference dwindles, and late result is good.To cardiopalmus, uncomfortable in chest, the angina pectoris due to the coronary heart disease, movable back dyspnea, sinus bradycardia, dizziness, headache due to artrial premature beat, the ventricular premature contraction, cerebral arteriosclerosis have curative effect preferably.To cerebral infarction, there is the side of promotion to prop up circulation and sets up and thrombolytic effect, to improve cerebral circulation, promote resuming function of brain cell.This medicine has following characteristics:

1, raw material is medicine commonly used, no poison in the prescription.

2, processing is simple, easily makes.

3, in the recent period, late result is all good, taking medicine can produce curative effect preferably about a week, (course of treatment) left and right sides may command symptom of taking medicine January is difficult for repeatedly.The arteriosclerotic development process that can slow down three courses of treatment of taking medicine has the effect of removing intra-arterial atheromatous plaque and vessel softening, but to the person of being in a bad way, needs the extended treatment time.

4, acute brain thromboembolism, the acute myocardial infarction that causes that come off has the thrombus effect to the atherosclerotic plaque ulceration.

5,, the effect that brings high blood pressure down is arranged to the hypertension due to atherosclerosis.

6, drug safety has no side effect.

The present invention through nearly more than ten years constantly grope improve, especially the special project research more than 8 years has developed into than tested recipe, treats nearly 360 many cases patients, total effective rate reaches about 95%.For showing the therapeutic effect of medicine of the present invention, nearly 3 years of applicant treats cerebral atherosclerosis, cerebral infarction and coronary atherosclerosis patient 188 examples, makes observation of curative effect and is reported as follows:

Case source: the clinic case of 2003.3----2006.3.

Case is selected: meet the tcm diagnosis standard that in August, 1987, the first coronary heart disease academic conference of whole nation Society of Internal Medicine was passed through discussion and reach " practical internal medicine " the 9th edition (Dai Ziying chief editor) coronary heart disease, anginal diagnostic criteria; Meet the 6th edition " neurological " diagnosing of cerebral infarction of national institution of higher education teaching material standard.

Character classification by age:＞60 years old 75 example,＞50 years old 41 example,＞40 years old 42 example,＜40 years old 9 example amounts to 188 examples.

The sick kind classified: coronary disease case 43 examples, and cerebral arteriosclerosis 112 examples, coronary heart disease merges cerebral arteriosclerosis 33 examples.

Efficacy determination:

Clinical cure: angina pectoris, uncomfortable in chest, cardiopalmus, the disappearance of breathing hard, dizzy, headache disappears, hemiplegia disappears substantially, and spirit muscle power is basic to be recovered, and the tongue arteries and veins is normal, and drug withdrawal did not have recurrence in three months.

Produce effects: angina pectoris, uncomfortable in chest, cardiopalmus, symptom such as breathe hard disappear substantially, and dizzy, headache disappears substantially, and limb function recovers substantially, and spirit muscle power is significantly improved, and the tongue arteries and veins is normal substantially, and electrocardiogram obviously improves, and drug withdrawal does not have recurrence January.

Effectively: the angina pectoris attacks number of times obviously reduces, and uncomfortable in chest, cardiopalmus, symptom such as breathe hard obviously alleviate, and dizzy, headache obviously alleviates, and limb function obviously improves, and spiritual muscle power makes moderate progress, and the tongue arteries and veins takes a turn for the better, and electrocardiogram improves, and still needing takes medicine keeps curative effect person.

Invalid: through treating one month, angina pectoris, uncomfortable in chest, cardiopalmus, breathe hard, tongue arteries and veins, electrocardiogram do not have change, dizzy, headache, limb function does not have the changer.

Statistical table

Table one: sex distribution table

Total routine number	The male	％	The women	％
					188	109	58	79	42

Table two: age distribution table

Total routine number	＞60 years old	％	＞50 years old	％	＞40 years old	％	＜40 years old	％
									188	75	40	41	21.8	42	22.4	9	4.8

Table three: coronary heart disease and cerebral arteriosclerosis distribution table

Total routine number	Coronary heart disease	％	Coronary disease and cerebral arteriosclerosis	％	Cerebral arteriosclerosis	％
							188	43	22.9	33	17.5	112	59.6

Table four: curative effect statistical table

Total routine number	Clinical cure	％	Produce effects	％	Effectively	％	Invalid	％
									188	79	42	85	45.2	15	8	9	4.8

The specific embodiment

Take by weighing raw material by following proportioning: (kilogram)

The Radix Astragali 10 Cortex Phellodendris 2 Fructus Crataegis 10 Rhizoma Zingiberiss 0.5 Semen Coicis 8 Fructus Citri Sarcodactylis 2

The Radix Paeoniae Alba 6 Rhizoma Chuanxiongs 2 Rhizoma Cyperis 2 Radix Puerariaes 10 Bulbus Fritillariae Thunbergiis 2 Fructus Aurantiis 2 XIANGQU 8

Pericarpium Trichosanthis 2 Rhizoma Atractylodis 3 Radix Salviae Miltiorrhizaes 10 Endothelium Corneum Gigeriae Galli 3 Radix Notoginseng 2 Radix Trichosanthis 2

Production method is as follows:

1. Endothelium Corneum Gigeriae Galli, Radix Notoginseng, Bulbus Fritillariae Thunbergii three flavors are ground into fine powder.

2. Rhizoma Atractylodis, Rhizoma Cyperi, Fructus Aurantii, Rhizoma Chuanxiong, the Rhizoma Zingiberis five tastes are extracted volatile oil.

3. the institute's medicinal residues that stay and the Radix Astragali, Cortex Phellodendri, Fructus Crataegi, Semen Coicis, Fructus Citri Sarcodactylis, the Radix Paeoniae Alba, Radix Puerariae, XIANGQU, Pericarpium Trichosanthis, Radix Salviae Miltiorrhizae, Radix Trichosanthis etc. ten in the step 2 are decocted with water three times simply, 1.5 hours for the first time, second and third time each 1 hour filtered, merging filtrate, filtrate are condensed into the thick paste shape.

4. in concentrating thick paste, add gained fine powder in the step 1, mixing, drying, be ground into fine powder, with gained volatile oil in the dehydrated alcohol dilution step 2, and make the fine powder mixing in dehydrated alcohol and 3: 1 ratio of volatile oil weight ratio, airtight 2 hours, incapsulate or be pressed into bulk promptly.

Instructions of taking: capsule dosage, 0.5 gram/grain, each 2 of consumption, every day three times, water is swallowed.

Claims (4)

1. a Chinese patent medicine for the treatment of atherosclerosis of cardio-cerebral arteria is characterized in that it is the medicament of being made by the following weight proportion raw material: Radix Astragali 10-15 part, Cortex Phellodendri 1-2 part, Fructus Crataegi 10-15 part, Rhizoma Zingiberis 0.3-0.5 part, Semen Coicis 7-9 part, Fructus Citri Sarcodactylis 2-3 part, Radix Paeoniae Alba 4-6 part, Rhizoma Chuanxiong 2-3 part, Rhizoma Cyperi 1-2 part, Radix Puerariae 10-15 part, Bulbus Fritillariae Thunbergii 2-3 part, Fructus Aurantii 2-3 part, XIANGQU 7-8 part, Pericarpium Trichosanthis 2-3 part, Rhizoma Atractylodis 2-4 part, Radix Salviae Miltiorrhizae 10-15 part, Endothelium Corneum Gigeriae Galli 2-3 part, Radix Notoginseng 2-3 part, Radix Trichosanthis 2-4 part.

2. the Chinese patent medicine of treatment atherosclerosis of cardio-cerebral arteria according to claim 1, wherein the weight proportion of each raw material is: 10 parts of the Radixs Astragali, 2 parts of Cortex Phellodendris, 10 parts of Fructus Crataegis, 0.5 part of Rhizoma Zingiberis, 8 parts of Semen Coiciss, 2 parts of Fructus Citri Sarcodactylis, 6 parts of the Radix Paeoniae Albas, 2 parts of Rhizoma Chuanxiongs, 2 parts of Rhizoma Cyperis, 10 parts of Radix Puerariaes, 2 parts of Bulbus Fritillariae Thunbergiis, 2 parts of Fructus Aurantiis, 8 parts of XIANGQU, 2 parts of Pericarpium Trichosanthiss, 3 parts of Rhizoma Atractylodis, 10 parts of Radix Salviae Miltiorrhizaes, 3 parts of Endothelium Corneum Gigeriae Galli, 2 parts of Radix Notoginseng, 2 parts of Radix Trichosanthis.

3. the Chinese patent medicine of treatment atherosclerosis of cardio-cerebral arteria according to claim 1 and 2 is characterized in that said medicament is capsule, powder or piece agent.

4. the preparation method of the Chinese patent medicine of treatment atherosclerosis of cardio-cerebral arteria according to claim 1 is characterized in that:

1. Endothelium Corneum Gigeriae Galli, Radix Notoginseng, Bulbus Fritillariae Thunbergii three flavors are ground into fine powder;

2. Rhizoma Atractylodis, Rhizoma Cyperi, Fructus Aurantii, Rhizoma Chuanxiong, the Rhizoma Zingiberis five tastes are extracted volatile oil;

3. with above-mentioned 2. in the institute medicinal residues that stay and the Radix Astragali, Cortex Phellodendri, Fructus Crataegi, Semen Coicis, Fructus Citri Sarcodactylis, the Radix Paeoniae Alba, Radix Puerariae, XIANGQU, Pericarpium Trichosanthis, Radix Salviae Miltiorrhizae, Radix Trichosanthis etc. ten decoct with water simply three times, 1.5 hours for the first time, second and third time each 1 hour filtered, merging filtrate, filtrate are condensed into the thick paste shape;

4. gained fine powder in concentrating thick paste, adding 1., mixing, drying, be ground into fine powder, dilute 2. middle gained volatile oil in dehydrated alcohol and 3: 1 ratios of volatile oil weight ratio with dehydrated alcohol, with above-mentioned fine powder mixing, airtight 2 hours, incapsulate or be pressed into bulk.