CN101524470B - Traditional Chinese medicine preparation for curing angiocardiopathy stent restenosis and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for curing angiocardiopathy stent restenosis and a preparation method thereof. The traditional Chinese medicine preparation comprises various components according to the parts by weight: 10-30 parts of dangseng, 10-30 parts of the root of red-rooted salvia, 10-30 parts of safflower, 10-30 parts of rhizoma cyperi, 10-30 parts of radix bupleuri, 10-30 parts of angelica, 10-30 parts of red paeonia, 10-30 parts of schisandra chinensis, 10-30 parts of pseudo-ginseng, 10-30 parts of asarum, 10-30 parts of heracleum hemsleyanum michaux, 10-30 parts of ophiopogon root, 10-30 parts of milk weteh, 10-30 parts of polygala tenuifolia, 10-30 parts of notopterygium root, 10-30 parts of spatholobus stem, 10-30 parts of rhizoma atractylodis, 10-30 parts of peach kernel, 5-10 parts of folium ginkgo, and 10-30 parts of the rhizome of chuanxiong. The traditional Chinese medicine preparation can effectively inhibit vascular smooth muscle of cell proliferation, platelet aggregation and thrombosis, reduces the issue rejection reaction and inhibits inflammatory reaction.

Description

A kind of Chinese medicine preparation and method for preparing of preventing and treating angiocardiopathy stent restenosis

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of Chinese medicine preparation and method for preparing of preventing and treating angiocardiopathy stent restenosis.

Background technology

The coronary heart disease traditional Chinese medical science belongs to " thoracic obstruction " category, and it is main observing with the deficiency of vital energy from the tongue arteries and veins, and expectorant stasis of blood sign is lighter, belongs to " blockage of the cardiac vessels " of the traditional Chinese medical science.It is improper that the cause of disease of coronary heart disease reduces work and rest, throws off restraint the food rich and fatty diet, or internal injury caused by excess of seven emotions, but these factors are not to make everybody suffer from coronary heart disease, but be decided by the prosperity and decline of healthy energy, and in healthy energy was deposited, heresy can not be done.And morbidity is artificially main with old age, and mostly the sick of old age is empty, so pathogenesis is a deficiency in origin and excess in superficiality.Void comprises the void of the five internal organs, but is principal contradiction to have a guilty conscience, have a guilty conscience and must involve yang blood and qi, and gently then be deficiency of vital energy blood deficiency, heavy then yang blood and qi is all empty, very then faint and take off.Coronary angiography shows that there be in various degree narrow in this type patient coronary artery, and some cases has abundant collateral circulation to form.At present, percutaneous transluminal coronary angioplasty (PTCA) and intracoronary stening need not be opened breast with it and obtain the effect of good arteria coronaria myocardial revascularization, have become one of critical treatment method of coronary heart disease.But postoperative restenosis coronarius (RS) still influences its clinical late result.Although intracoronary stent improves in many ways, introduce several different methods such as speckle rotary-cut art and roentgenization and multiple medicinal application in clinical in addition postoperative intervention, the result is still unsatisfactory.

How to prevent RS to become one of major subjects of current cardiology area research.The pathogenesis of RS is still not fully aware of at present, and the traditional Chinese medical science is thought the category that belongs to Blood stasis of restenosis.Atherosclerosis causes that luminal stenosis or obstruction are the main causes that causes ischemic heart desease, causes every year 50～600,000 people dead.PTCA and support are inserted at present and are accepted and be applied to treat coronary heart disease widely.Though PTCA treatment coronary heart disease clinical effectiveness is satisfactory, its acute vascular obturation, subacute stent thrombosis formation and postoperative vascular restenosis have limited the development of PTCA to a certain extent.It is reported 5%-10% patient when PTCA, acute or subacute coronary occlusion can take place; And behind the PTCA coronary restenosis up to 30%-50%.Acute or subacute coronary occlusion is mainly because elasticity of blood vessels bounces back and/or platelet causes in lesions deposition and then formation thrombosis.

IVUS is verified, and the main mechanism of restenosis has vascular remodeling and neointimal hyperplasia due to the blood vessel elasticity retraction after the successful PTCA.Coronary artery bracket can prevent vascular remodeling; And postoperative obtains bigger lumen diameter; Reduced the generation of restenosis, but owing to balloon expandable, support are inserted process and caused the local vascular inner film injury, thereby stimulate the still inducible restenosis of tunica intima hamartoplasia to take place.How solving in-stent restenosis becomes the focus and the difficult problem of coronary heart disease interventional therapy.

As previously mentioned, the hyperplasia of thrombosis and new intima tissue is the main cause that causes in-stent restenosis, therefore, suppresses thrombosis and/or hamartoplasia treatment of vascular restenosis more effectively.Bracket for eluting medicament and attraction endotheliocyte supports such as rapamycin, paclitaxel, VEGF, estradiol; Arise at the historic moment; Can reduce restenosis, but still have thrombosis, especially late period and the formation of tardy advanced thrombus in the support; And need 2-3 couplet antiplatelet drug to use more than 1 year, become the problem that doctor and patient is all very had a headache.Chemoprophylaxis restenosiss such as anticoagulant, platelet suppressant drug, prostaglandin antagonists, accent fat, angiotensin converting enzyme inhibitor and SSA were once adjusted or improved to western medical treatment, but all the end obtains satisfied result.The existing major defect of above-mentioned clinical treatment present situation is that specific aim is not strong, curative effect is undesirable, the SM time is long, and patient's compliance is poor, and becomes the bottleneck of restriction clinical practice.

Summary of the invention

Technical problem to be solved by this invention is; A kind of Chinese medicine preparation and method for preparing of preventing and treating angiocardiopathy stent restenosis is provided; To preventing and treating the deficiency that restenosis medicaments exists in the angiocarpy bracket such as coronary heart disease at present, the technical scheme that reduces smooth muscle cell proliferation is provided.

For solving the problems of the technologies described above, the present invention provides a kind of Chinese medicine preparation of preventing and treating angiocardiopathy stent restenosis, and the ratio of weight and number of various components is: 10～30 parts of Radix Codonopsis, 10～30 parts of Radix Salviae Miltiorrhizaes, 10～30 parts on Flos Carthami; 10～30 parts of Rhizoma Cyperis, 10～30 parts of Radix Bupleuri, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Radix Paeoniae Rubra, 10～30 parts of Fructus Schisandrae Chinensis; 10～30 parts of Radix Notoginseng, 10～30 parts of Herba Asaris, 10～30 parts of Radix Angelicae Pubescentiss, 10～30 parts of Radix Ophiopogonis; 10～30 parts of the Radixs Astragali, 10～30 parts of Radix Polygalaes, 10～30 parts of Rhizoma Et Radix Notopterygiis, 10～30 parts of Caulis Spatholobis; 10～30 parts of Rhizoma Atractylodis, 10～30 parts in Semen Persicae, 5～10 parts of Folium Ginkgos, 10～30 parts of Rhizoma Chuanxiongs.

The Chinese medicine preparation of said control angiocardiopathy stent restenosis, the ratio of weight and number of various components can be preferably: 10～15 parts of Radix Codonopsis, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts on Flos Carthami, 10～15 parts of Rhizoma Cyperis; 10～15 parts of Radix Bupleuri, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of Fructus Schisandrae Chinensis; 10～20 parts of Radix Notoginseng, 10～20 parts of Herba Asaris, 10～20 parts of Radix Angelicae Pubescentiss, 10～20 parts of Radix Ophiopogonis; 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Polygalaes, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～20 parts of Caulis Spatholobis; 10～20 parts of Rhizoma Atractylodis, 10～20 parts in Semen Persicae, 5～10 parts of Folium Ginkgos, 10～20 parts of Rhizoma Chuanxiongs.

The Chinese medicine preparation of said control angiocardiopathy stent restenosis, the ratio of weight and number of various components also can be preferably: 10～20 parts of Radix Codonopsis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts on Flos Carthami, 10～20 parts of Rhizoma Cyperis; 10～20 parts of Radix Bupleuri, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Fructus Schisandrae Chinensis; 10～15 parts of Radix Notoginseng, 10～15 parts of Herba Asaris, 10～15 parts of Radix Angelicae Pubescentiss, 10～15 parts of Radix Ophiopogonis; 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Polygalaes, 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Caulis Spatholobis; 10～15 parts of Rhizoma Atractylodis, 10～15 parts in Semen Persicae, 5～10 parts of Folium Ginkgos, 10～15 parts of Rhizoma Chuanxiongs.

The Chinese medicine preparation of said control angiocardiopathy stent restenosis, the ratio of weight and number of various components also can be preferably: 15～25 parts of Radix Codonopsis, 15～25 parts of Radix Salviae Miltiorrhizaes, 15～25 parts on Flos Carthami, 15～25 parts of Rhizoma Cyperis; 15～25 parts of Radix Bupleuri, 15～25 parts of Radix Angelicae Sinensis, 15～25 parts of Radix Paeoniae Rubra, 15～25 parts of Fructus Schisandrae Chinensis; 15～25 parts of Radix Notoginseng, 15～25 parts of Herba Asaris, 15～25 parts of Radix Angelicae Pubescentiss, 15～25 parts of Radix Ophiopogonis; 15～25 parts of the Radixs Astragali, 15～25 parts of Radix Polygalaes, 15～25 parts of Rhizoma Et Radix Notopterygiis, 15～25 parts of Caulis Spatholobis; 15～25 parts of Rhizoma Atractylodis, 15～25 parts in Semen Persicae, 5～10 parts of Folium Ginkgos, 15～25 parts of Rhizoma Chuanxiongs.

When the Chinese medicine preparation of said control angiocardiopathy stent restenosis, medicine are fried in shallow oil decoction in use and are taken, but 1 dose of every day, decocting is obeyed at twice, and 30 days is a course of treatment.

The Chinese medicine preparation of said control angiocardiopathy stent restenosis, its dosage form can be honey refining pill, hydration pill, capsule, oral liquid, tablet, drop pill or syrup.

For solving the problems of the technologies described above, the present invention provides a kind of method for preparing of preventing and treating the Chinese medicine preparation of angiocardiopathy stent restenosis again, and the dosage form of said Chinese medicine preparation is a honey refining pill, and its preparation method may further comprise the steps:

Said component was soaked 30 minutes to 1 hour, and heated and boiled 30 minutes is filtered filtrate for later use; Filtering residue adds water, and heating was boiled 30 minutes for the second time, refiltered filtrate for later use; Filtering residue adds water again, and heated and boiled is 40 minutes for the third time, filters; Three filtratings are lumped together, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, dries postcooling, and mixing with Mel is twisted into slice; With every 5g is ball wax seal packing.

For solving the problems of the technologies described above, the present invention also provides a kind of method for preparing of preventing and treating the Chinese medicine preparation of angiocardiopathy stent restenosis, and the dosage form of said Chinese medicine preparation is a capsule, and its preparation method may further comprise the steps:

Said component is added 10 times of weight amount ethanol, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL is behind the sucking filtration, when the relative density of filtrating is 20 ℃ 1.08; Said filtrate flow is the adsorption resin column of 10L through volume; Use the deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, 95% ethanol elution of 5 times of resin column volumes of reuse is collected ethanol elution; Remove alcohol solvent; Obtain component medicated powder, incapsulate and be made as capsule, every capsules dress 0.3g.

For solving the problems of the technologies described above; The present invention also provides a kind of method for preparing of preventing and treating the Chinese medicine preparation of angiocardiopathy stent restenosis; The dosage form of said Chinese medicine preparation is a tablet, and its preparation method may further comprise the steps: said medicine chopping is joined in the multi-function extractor, and the adding ratio of weight and number is that 3000 parts water logging was steeped 30～40 minutes; Decoct after 1.5 hours, decoction liquor is subsequent use for the first time in taking-up; Medicinal residues adding ratio of weight and number is after 3000 parts decocting boils 1 hour, to take out decoction liquor for the second time, twice decoction liquor is merged filter; It is 1000 parts solution that filtrate decompression is concentrated into ratio of weight and number, staticly settles 24～36 hours, draws supernatant; Add starch after being heated to 40～50 ℃, heating is concentrated into pasty state, puts into baking oven; Be controlled at 80 ℃, oven dry postcooling, film-making, drying, molding, packing.

For solving the problems of the technologies described above, a kind of method for preparing of preventing and treating the Chinese medicine preparation of angiocardiopathy stent restenosis, the dosage form of said Chinese medicine preparation are drop pill; Its preparation method may further comprise the steps: with Rhizoma Cyperi, and Herba Asari, Rhizoma Chuanxiong and Radix Notoginseng add the water that its weight sum 5-7 doubly measures; Put into multi-function extractor, keep air pressure, decocted 2 hours at 0.04-0.06mPa; Extract its water soluble ingredient, keep its pungent penetrating odor; Repeat above-mentioned steps and extracted extracting liquid filtering 100 mesh sieves once more 1.5 hours; With the refining filtrating of adsorbent resin, use ethanol elution; It is 1.33-1.35 that eluent is evaporated to density, and wherein input air pressure is 0.04-0.06mPa, and vacuum is-0.076-0.088mPa stand for standby use; All the other components add the water that its weight sum 5-7 doubly measures; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours, extracts its water soluble ingredient; Repeating above-mentioned steps extracted 1 hour once more; The filter extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate is to 1: 1 W/V of crude drug amount; Concentrated solution adds ethanol precipitation; Ethanol precipitation liquid filters with 100 mesh sieves; Vacuum concentrated filtrate, admission pressure are 0.04-0.06mPa, and vacuum is 0.076-0.088mPa; The use sephadex chromatography is refining, uses ethanol elution; It is 1.33-1.35 that eluent is concentrated into density, leaves standstill; Get above-mentioned two kinds and leave standstill liquid adding Polyethylene Glycol-6000, mix; The mixture heated fusion; With the drop pill machine mixture is processed compound dripping pill.

Drop pill machine technology parameter is following: the drip irrigation temperature keeps 85-95 ℃, and condensed fluid liquid paraffin temperature is lower than 8 ℃, and the water dropper internal diameter is 1.6mm, and the water dropper external diameter is 2.5mm, and water dropper is 15cm apart from the liquid paraffin surface distance; Centrifugal, rotating speed 800-1100rpm after 15 minutes, removes deparaffnize and gets final product.Be quick acting, drop pill of the present invention is made into to dissolve the piller of absorption in the Sublingual rapidly, and it can go into blood fast, through cardiac muscle, allevating angina pectoris rapidly.

Compared with prior art, the present invention has clear superiority: the hypertrophy that suppresses smooth muscle cell; Prevent platelet aggregation, suppress the formation of thrombosis, reduced stimulation, further prevent stent restenosis smooth muscle cell; Reduce organ rejection episodes, the inflammation-inhibiting reaction; Can significantly reduce postoperative complication.Advantages such as the present invention has convenient drug administration, and medicament is easy to make, and is with low cost.The present invention adopts the Chinese crude drug of the different property of medicine, has carried out the science compatibility, can reach ideal therapeutic effect, and safety, and toxic and side effects is little, and is easy to use, and treatment cycle is short, can obtain good social benefit and economic benefit.

The specific embodiment

The coronary heart disease traditional Chinese medical science belongs to " thoracic obstruction " category, and it is main observing with the deficiency of vital energy from the tongue arteries and veins, and expectorant stasis of blood sign is lighter, belongs to " blockage of the cardiac vessels " of the traditional Chinese medical science.It is narrow in various degree that its coronary angiography shows that this part patient's coronary artery exists.It is improper that the cause of disease of coronary heart disease reduces work and rest, throws off restraint the food rich and fatty diet, or mostly internal injury caused by excess of seven emotions, particularly old age sick be void, so pathogenesis is a deficiency in origin and excess in superficiality.Void comprises the void of the five internal organs, but is principal contradiction to have a guilty conscience, have a guilty conscience and must involve yang blood and qi, and gently then be deficiency of vital energy blood deficiency, heavy then yang blood and qi is all empty, very then faint and take off.Actually be " expectorant " and " stasis of blood ".As for empty and real who problem after whom earlier, general theory is thought has void earlier, after reality is just arranged.Having a guilty conscience, it is smooth to cause that QI and blood loses, gas and blood, and interdependence between yin and yang, qi as the commander of blood, blood being the mother of qi, and blood is capable with gas, and then blood is capable up to row, and gas is that initiatively blood is passive.The deficiency of vital energy is then given birth to expectorant, stops then disorder of QI movement in the phlegm-damp, the stagnation of QI hyperamization stasis of blood, and deficiency of vital energy blood is capable weak, the hyperamization stasis of blood again, blood stasis can react on gas, causes the stagnation of QI or the deficiency of vital energy further increases the weight of.

People are being perplexed in the high rate of restenosis always behind PTCA and the stent endoprosthesis, and PTCA postoperative blood vessel is logical, can does stasis of blood resistance remove, why also restenosis? See that from endogenous cause of ill this is because the problem that the positive deficiency of vital energy and the five internal organs are correlated with is also unresolved.Often because of the high Sheng of liver-yang, it is impaired to involve the heart-yin like patients with hypertension; Again or PTCA postoperative decline of the fire from the gate of life, the deficiency of heart-YANG hyperamization row that declines is weak and the stasis of blood is stopped heart arteries and veins.In addition, the official of lung for passing on from one to another, the spleen being the source of producing phlegm, asthenia of pulmonosplenic qi have influence on the heart, and cause blockage of phlegm and blood stasis heart network (obstruction of heart-QI).Domestic data shows that smoking, advanced age etc. are the independent hazard factors that support is inserted the back restenosis behind the stenting.External data shows, hypertension (liver and heart theory of correlation), and advanced age (the positive deficiency of vital energy), hyperlipemia, smoking (expectorant), RS can quickened or cause to psychological factor (stagnation of QI due to depression of the liver) etc.The traditional Chinese medical science thinks that mostly smoker, hyperlipemia person are the internal resistance of the expectorant stasis of blood, and advanced age, mostly the person was the positive deficiency of vital energy, can infer to reduce phlegm with QI invigorating that to invigorate blood circulation be that master's treatment by Chinese herbs possibly be the effective way of control RS.

Angina pectoris belongs to traditional Chinese medical science thoracic obstruction category, blockage of the cardiac vessels, the blood stasis of blood stagnates be its main diseases because of.It also is the basic pathogenesis that the coronary heart disease restenosis after interventional therapy takes place.So blood circulation promoting and blood stasis dispelling should be the fundamental law of control restenosis.Based on above understanding, the beginning prescription: Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Semen Persicae, Flos Carthami, Radix Salviae Miltiorrhizae, Radix Notoginseng are the article of activating blood circulation and dissipating phlegm; Warming middle-JIAO is regulated the flow of vital energy, the Radix Bupleuri depressed liver-energy dispersing and QI regulating; All medicines are 5 adapteds mutually, to reach blood circulation promoting and blood stasis dispelling, regulating qi and dredging collateral, play the effect that prevents restenosis jointly.

But the general medical history of the thoracic obstruction patient normal simulataneous insufficiency and excessive of length is to suffer from, and is so-called empty, not the void thanks to of exogenous QI, blood, yin, yang; Real is the stagnation of QI, turbid, the cold coagulation of expectorant often, so clinical need on essential drugs, with the card plus-minus, are executed flexibly and controlled.Clinical practice proves, adopts the Therapeutic Method of the combination of Chinese and Western medicine, can reduce the restenosis rate behind the coronary heart disease interventional therapy, reduces reconstructing blood vessel, improves patients ' life quality.The initiative of Chinese medicinal formulae is based upon on the basis of coronary heart disease tcm syndrome characteristics and treatment effectiveness.Research shows, patients with coronary heart disease shows as that the deficiency of vital energy, blood stasis, expectorant are turbid more, cold coagulation or the deficiency of YIN, the stagnation of QI etc., but is main symptom with the blood stasis due to qi deficiency.Simultaneously, many researchs confirm that after patients with coronary heart disease was taken benefiting QI for activating blood circulation Chinese medicine, symptom improved, and cardiac function significantly improves.According to Chinese medical discrimination characteristics such as " pathogen usually intruding into collateral in protracted disease, the double silt of prolonged illness, prolonged illness must be felt frustrated ", in conjunction with clinical practice for many years, people propose the viewpoint that " promoting blood circulation to remove obstruction in the collateral, QI invigorating activate yang " opinion is controlled coronary heart disease.Caulis Spatholobi, Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis, Radix Angelicae Pubescentis and Rhizoma Atractylodis activating blood circulation to dissipate blood stasis and dredge the collateral; Fructus Schisandrae Chinensis, Herba Asari and Radix Ophiopogonis replenishing qi and promoting blood flow, the temperature gas that activates yang, Radix Polygalae is calmed the nerves; Folium Ginkgo has very strong antioxidation; To strengthen the merit of promoting blood circulation to remove obstruction in the collateral.All medicines share and play the effect that promoting blood circulation to remove obstruction in the collateral, QI invigorating activate yang, giving consideration to both the incidental and fundamental altogether.All medicine compatibility ability anticoagulant and thrombosis, microcirculation improvement increases coronary blood flow; The Radix Astragali, the extract of Radix Codonopsis has cardiotonic, can improve heart stroke and cardiac index, has effects such as blood vessel dilating, Rhizoma Cyperi blood pressure lowering, microcirculation improvement simultaneously; The effect of excited heart, enhancing coronary blood flow and myocardial contraction.

Radix Angelicae Sinensis: its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

The Radix Astragali is main with tonify deficiency, ability invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and the ability enhancing body's immunological function, therefore can also be used to prevent the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " Radix Astragali is can tonifying five ZANG-organs all empty, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.

Radix Codonopsis property is flat, sweet in the mouth, little acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst." book on Chinese herbal medicine justice " carries: Radix Codonopsis power ability spleen reinforcing nourishing the stomach, and the lung moistening and production of body fluid promoting, gas in the tendon fortune, this is very mutually not far away with Radix Ginseng.Its outstanding valuable person, spleen invigorating fortune and not dry is then grown stomach-Yin and wet, and lung moistening and do not violate is cold and coolly nourished blood and is not grown greasyly partially, inspires clear sun, gas in the vibration, and do not have dry fraud just.Radix Astragali QI invigorating, can rise enriching spleen-QI, again can the lung benefiting consolidating superficial resistance.The Radix Codonopsis QI invigorating can only the spleen invigorating QI invigorating, the power of no consolidating superficial resistance, but Radix Codonopsis can also supplementing QI for promoting the production of body fluid, and the Radix Astragali does not then have the effect of promoting the production of body fluid, and the Radix Astragali is held concurrently can diuretic, and Radix Codonopsis does not have the diuretic effect.This two flavors medicine share can invigorating the spleen and replenishing QI, improves resistance.

Semen Persicae is bitter, and is sweet, puts down the special medicine that closes for blood stasis blood.Bitter to let out stagnant blood, sweet with tissue regeneration promoting blood." medicineization justice ": Semen Persicae, bitter in the mouth can rush down heat in blood, and the body profit can be grown dryness of the intestine.If gross weight grinds many usefulness, walk Liver Channel, main broken blood-retention, water month by month; And pain all over, extremity wood numbness, left hemiplegia, left sufficient patient; Relax through the promoting the circulation of blood of invigorating blood circulation with it, the merit of eliminating blood stasis to promote regeneration of blood is arranged,, go into large intestine if few usefulness is mashed in peeling; Control blood depletion and just close, the dry dyschezia of blood with its make moist removing heat from blood and blood, has relieving accumulation of pathogens to lead to stagnant power.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carry it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Flos Campsis, Caulis Spatholobi is for oral administration to be that the treatment blood stasis is not loose the good medicine that nourishing blood silt is invigorated blood circulation.

Flos Carthami is warm in nature, acrid in the mouth.Cure mainly the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy goes into the blood chamber, and delirium is gone mad; Or vexed interior the expanding of blood, the sudden syncope with rigidity is that all puerperal, non-Flos Carthami can not be decided at card as extremely.All friendship like the obstructed and cold and heat of amenorrhea done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollen burst uneasyly, is cards of disharmony between QI and blood all, and non-Flos Carthami can not be transferred." medicineization justice ": Flos Carthami, kind tonneau passages through which vital energy circulates is gas medicine in the blood, can rush down and can mend, and wonderful justice is respectively arranged.If many with three, four money, then too hot temperature is wandered away blood.With Lignum Sappan removing blood stasis blood, to close Cortex Cinnamomi and stimulate the menstrual flow and close, assistant is returned, Chinese herbaceous peony is controlled all over or the pricking caused by the stagnation of QI and blood of breast abdomen, and this its row is led and is invigorated blood circulation also.If use seven, eight fens less, with dispersing liver-energy, helping the sea of blood, the void of enriching blood greatly, this its transfer smooth and with blood also; If end with two, three minutes, go into the heart to join painstaking effort, dismiss heart channel pathogenic fire, make the blood mediation, this its nourishing and hemopoietic are also; The justice of component number, meagre.Experiment proof Flos Carthami has following effect to cardiovascular system: 1) suppress the heart effect: Flos Carthami decoct low dose can make Bufo siccus isolated heart and rabbit in slightly excitement of systemic heart, makes heart beating strong, and amplitude strengthens; Heavy dose then has inhibitory action to heart, makes decreased heart rate, and myocardial contraction weakens, and SV reduces.2) experimentation to CF shows: Flos Carthami water extract and Flos Carthami water soluble mixt-Carthamus yellow have the effect of coronary blood flow increasing and myocardial nutrition property blood flow; The coronary artery dilating of Flos Carthami ethanol extraction and the effect of coronary blood flow increasing are then not obvious or do not have an influence.3) experimentation to expeirmental myocardial ischemia and myocardial infarction shows: cause on the animal model of expeirmental myocardial ischemia or myocardial infarction rabbit, rat, dog etc., Flos Carthami and preparation thereof all have antagonism in various degree.Flos Carthami can make the rat or the rabbit acute myocardial ischemia that cause because of pituitrin that obvious protective effect is arranged; Can make repeatedly of short duration blocking-up coronary flow cause the degree of anesthetized dog acute myocardial ischemia obviously to alleviate; Scope is dwindled; Decreased heart rate; And the edge in protection acute myocardial infarction district, district and dwindle infarction size and reduce the amplitude that the marginal zone ECG ST section is raised, thus improve the supply-demand relationship of ischemic myocardium oxygen.

Rhizoma Cyperi gas is flat, and the little hardship of acrid in the mouth is little sweet.The resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast." detailed outline " carries: the cold epidemic disease of the seasonal epidemic pathogens that looses, and sharp three warmers are separated six kinds of stagnation-syndromes, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot; Abdominal distention, beriberi is ended trusted subordinate, limbs, head, order, tooth, all pains of ear, and ulcer sores is spitted blood; Hematochezia, hematuria, married woman's bleeding not during menses, month time is uncomfortable, tire all kinds of diseases and ailments in preceding puerperal.Rhizoma Cyperi has the good resolving depression effect of regulating the flow of vital energy, and is used for the breast side of body and the stomach abdominal distention and pain of depression of liver-QI.

The sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock.Be rare Chinese medicine, but give birth to have good hemostasia effect, significant hemopoietic function with hemostasia and dissipation blood stasis, reducing swelling and alleviating pain; Can tighten and improve the arteria coronaria microcirculation, Radix Notoginseng is used as medicine with a long history, acts on peculiarly being regarded as the treasured in the medicine by ancient Chinese medicine doctor, so the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) " is arranged." it is little sweet and bitter to distinguish the flavor of, quite seemingly the flavor of Radix Ginseng for Radix Notoginseng." " all canes are pounced on trauma, and the dripping person of blood stasis chews promptly ending of mashed net for catching birds or fish immediately, and bruise the person promptly dissipate.If when receiving cane, clothes one, two money earlier, then the blood centre of punch not should be obeyed it behind the cane especially, and obey also good puerperal.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of the cloudy blood system of fainting, so can control all disorders of blood "." book on Chinese herbal medicine is looked for the truth " record: " Radix Notoginseng, common people only know the function hemostasis and pain-relieving.Hardly realize bitterly and ache work that blood ends because of applying the blood that looses because of blood stasis.The bitter temperature of Radix Notoginseng abnormal smells from the patient can be in its blood stasis of blood systemization.”

Radix Polygalae is bitter, hot, tepor.GUIXIN, kidney, lung meridian.Function cures mainly the Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm detumescence.Be used for the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Be applied to insomnia and dreamful sleep, severe palpitation, forgetful.These article toil is warm in nature, property is kind lead off sensible, happily gas and mind tranquilizing and the heart calming, can lead to kidney qi and strong will is not forgotten, be restoring normal coordination between the heart and kidney, stable mind, the Fructus Alpiniae Oxyphyllae good merchantable brand of knowledge by force.Cure mainly the diseases such as malaise, insomnia, palpitation with fear of disarmony between the heart and kidney, normal and the same usefulness of medicinal for tranquilizing mind such as Poria cum Radix Pini, Dens Draconis, Cinnabaris are like Radix Polygalae ball (" the Zhang Shi doctor is led to "); Control forgetful card, normal and Radix Ginseng, Poria, the same usefulness of Rhizoma Acori Graminei are loose (" prescriptions worth thousand gold ") as happy, add Poria cum Radix Pini, promptly do not forget to loose (" Standards of Diagnosis and Treatment ") as if Fang Zhongzai." book on Chinese herbal medicine is just ": Radix Polygalae, the wholwe-hearted kidney of merit, so but the relieving palpitation spasmolytic, the peace that exorcises evil spirits dream, Yang strengthening and life essence tonifying, strong will power-assisted.With its gas lift, so same Radix Ginseng, Radix Glycyrrhizae, Semen Ziziphi Spinosae, the utmost point can be lifted and fall into consolidating semen, handing-over extreme misery

Radix Paeoniae Rubra is bitter, is slightly cold.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.The Radix Paeoniae Rubra branch excess-heat that can purify the blood, dissipating blood stasis blood is detained.These article function and Cortex Moutan are close, so normal be usefulness with the Cortex Moutan mutual reinforcement between.But the effect of Cortex Moutan clearing away heat and cooling blood is preferable, and the branch excess-heat that can purify the blood can be controlled fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for the blood system excess-heat, is good at promoting blood circulation to remove blood stasis.

Radix Bupleuri is bitter, is slightly cold.Return liver, gallbladder meridian.Function is brought down a fever soothing liver-QI, yang invigorating with curing mainly to evacuate.Be used for cold, fever, alternate attack of chill and fever, malaria, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.Be soothing the liver good medicine of fostering the spirit of nobility.

The Herba Asari acrid in the mouth, temperature is dispeled the wind, cold expelling, row water is had one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia." property of medicine opinion " carries: control cough with dyspnea, and aversion to wind, public attention, spasm of the extremities, the settling five organs six internal organs add courage, and peeling rheumatism ancient term for country school can end under the eye lacrimation induced by wind pathogen, makes eye bright, and opens in the heart to stagnate, and removes toothache, and main blood closes, married woman's blood drop lumbago.Herba Asari has heart tonifying, resisting myocardial ischemia, rising blood pressure.Isolated experiment shows that Herba Asari volatile oil has tangible excitation to rabbit, arteries and veins rat heart, shows as positive inotropic, the positivity frequency effect, and can increase coronary flow.To the experimental cardiogenic shock of dog, Herba Asari can improve effects such as its mean arterial pressure, left constant pressure peak value and crown blood sinus flow, and its action intensity is similar with dopamine, but it does not accelerate heart rate.

The detoxifcation of Radix Angelicae Pubescentis dispelling wind, blood circulation promoting and blood stasis dispelling, pain relieving.Be used for variola, traumatic injury, headache, lumbago.The property hot, bitter in the mouth, temperature.Go into lung, spleen, kidney three warps.The heart, vascular system there is certain inhibitory action.The Radix Angelicae Pubescentis crude preparation by using gives anesthetized dog or cat intravenous injection, and hypotensive effect is arranged, but not lasting.The tincture effect is greater than decoct.Cutting off vagus nerve does not influence its blood pressure lowering, and behind the injecting atropine, hypotensive effect receives part or all of inhibition.Isolated frog heart there is inhibitory action.When decoct pours at frog lower limb, pressor effect is arranged.

The Fructus Schisandrae Chinensis temperature; Sour, sweet; Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.Fruit is made Chinese medicine function supplementing QI for promoting the production of body fluid, the nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, is calmed the nerves, and can control diseases such as chronic cough dyspnea due to deficiency, the few xerostomia in Tianjin, seminal emission chronic diarrhea, forgetful insomnia.The pharmacological testing proof can be regulated central nervous system's excitement and process of inhibition, promotes body metabolism, regulates the secretion of gastric juice and bile, and hepatitis convalescent period transaminase rising person is had the reduction effect.

Sweet, the mildly bitter flavor of property Radix Ophiopogonis is slightly cold.GUIXIN, lung, stomach warp.Function with cure mainly YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Be used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Control dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation is quenched one's thirst, and hinder in calentura Tianjin, dry mouth and throat, constipation.These article are sweet cold clear and rich, the heat of the kind lung that clears away heart-fire and yin nourishing relieving restlessness, and holding concurrently can clear and rich gastrointestinal and quench the thirst and moisturize.Effect with anti-experimental character arrhythmia, increase coronary flow.

Rhizoma Et Radix Notopterygii property is hot, bitter in the mouth, temperature.Return bladder, kidney channel.Function cures mainly cold expelling, dispels the wind dehumidifying, pain relieving.Be used for the anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.Be used for anemofrigid cold, the headache body is painful.The hot temperature of these article, gas is male and loose, and the power of delivering is strong; The heresy of main loose Taiyang channel ailment said due to cold or exposure and cold-damp; Have that cold expelling dispels the wind, the merit of removing dampness to relieve pain, so kindly control wind-cold damp pathogen and attack table, fever with aversion to cold, the flesh table is lossless, headache stiffness of the nape, limb aching pain person; The same usefulness of medicine such as normal and Semen Persicae, Herba Asari, Rhizoma Atractylodis, Rhizoma Chuanxiong are like Notoptreygium Decoction of Nine Ingredients; If cold-damp lays particular stress on, headache heavy sensation of the body person, but medicines such as compatibility Radix Angelicae Pubescentis, manuscript, Rhizoma Chuanxiong are like Decoction of Notopterygium for Rheumatism.The Rhizoma Et Radix Notopterygii tanginess is to make the good volatile oil of drop pill.

Rhizoma Atractylodis property is hot, bitter in the mouth, temperature.Return spleen, stomach, Liver Channel.Function cures mainly drying damp and strengthening spleen, and expelling wind and cold makes eye bright.Be used for distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Influence to cardiovascular system shows that Rhizoma Atractylodis have slight inhibitory action to the Bufo siccus heart, and Bufo siccus hind leg blood vessel is had slight dilating effect.The low dose of intravenous injection of Rhizoma Atractylodis extractum can make rabbits blood pressure slightly rise, and heavy dose then makes blood pressure drops.The relevant pharmacological action of the drying damp and strengthening spleen effect of Rhizoma Atractylodis for adjustment gastrointestinal motility function, antiulcer, protect the liver, antibacterial etc.The main effective ingredient of Rhizoma Atractylodis is to be the volatile oil of representative with sagittol and hinesol.Rhizoma Atractylodis are to the influence of blood glucose, and anti-hypoxia, maincenter inhibition, antitumor, the calcification of promotion skeleton reach the effects such as influence to cardiovascular system, then are the modern study progress of its pharmacological action.

Rhizoma Chuanxiong is gone into liver, spleen, three warmers three warps.Function cures mainly activating QI to alleviate the depression, and the method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache and revolve dizzyly, the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." detailed outline " carries: " dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine is removed vascular smooth muscle (aorta) spasm (epinephrine causes).Can expand coronary vasodilator, coronary blood flow increasing.The antagonism pituitrin causes myocardial ischemia-anoxemia.Alleviate the myocardial infarction lesion degree that the ligation arteria coronaria causes.

Folium Ginkgo is sweet, bitter, puckery, and is flat.GUIXIN, lung meridian.Function cures mainly astringes the lung, and relievings asthma blood circulation promoting and blood stasis dispelling, pain relieving.Be used for cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia, anticoagulant.The ability blood circulation promoting, prevention coronary heart disease.There have been 100,015,000 years on earth in Semen Ginkgo, and the length in its life-span occupies first of each plant, is called " plant living fossil " by scientist.The leaf of Semen Ginkgo contains the number of chemical composition can go into Chinese medicine, and the Chinese Academy of Sciences and lot of domestic and foreign medical expert discover in recent years: can extract the effective medicinal ingredient of kind more than 160 in the Folium Ginkgo.Wherein, flavone compound is 35 kinds; 17 seed amino acids and various trace elements.Can control coronary heart disease in advance, prevent effects such as hypertension, apoplexy, diabetes.

The present invention can effectively suppress the hypertrophy of smooth muscle cell; Prevent platelet aggregation, suppress the formation of thrombosis, reduced stimulation, further prevent restenosis behind the support smooth muscle cell; Reduce organ rejection episodes, suppressed inflammatory reaction; Can significantly reduce postoperative complication.Effects such as blood vessel dilating, blood pressure lowering, microcirculation improvement; The effect of excited heart, enhancing coronary blood flow and myocardial contraction.Advantages such as the present invention has convenient drug administration, and medicament is easy to make, and is with low cost.Can obtain good social benefit and economic benefit.

The manufacturing process of the present invention's honey refining pill is: Radix Codonopsis 3000g, Radix Salviae Miltiorrhizae 3000g, Flos Carthami 3000g, Rhizoma Cyperi 3000g, Radix Bupleuri 3000g; Radix Angelicae Sinensis 3000g, Radix Paeoniae Rubra 3000g, Fructus Schisandrae Chinensis 3000g, Radix Notoginseng 3000g, Herba Asari 3000g; Radix Angelicae Pubescentis 3000g, Radix Ophiopogonis 3000g, Radix Astragali 3000g, Radix Polygalae 3000g, Rhizoma Et Radix Notopterygii 3000g; Caulis Spatholobi 3000g, Rhizoma Atractylodis 3000g, Semen Persicae 3000g, Folium Ginkgo 100g, Rhizoma Chuanxiong 3000g.Soak medical material 30 minutes to 1 hour, heated and boiled 30 minutes is filtered filtrate for later use; Filtering residue adds water, and heating was boiled 30 minutes for the second time, refiltered filtrate for later use; Filtering residue adds water again, and heated and boiled is 40 minutes for the third time, filters; Three filtratings are lumped together, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, and powdered being mixed in Mel of oven dry postcooling is twisted into slice; With every 5g is ball wax seal packing.

The manufacturing process of capsule of the present invention is: get Radix Codonopsis 3000g, Radix Salviae Miltiorrhizae 3000g, Flos Carthami 3000g, Rhizoma Cyperi 3000g, Radix Bupleuri 3000g; Radix Angelicae Sinensis 3000g, Radix Paeoniae Rubra 3000g, Fructus Schisandrae Chinensis 3000g, Radix Notoginseng 3000g, Herba Asari 3000g; Radix Angelicae Pubescentis 3000g, Radix Ophiopogonis 3000g, Radix Astragali 3000g, Radix Polygalae 3000g, Rhizoma Et Radix Notopterygii 3000g; Caulis Spatholobi 3000g, Rhizoma Atractylodis 3000g, Semen Persicae 3000g, Folium Ginkgo 100g, Rhizoma Chuanxiong 3000g.Add 10 times of amount ethanol, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, the relative density of filtrating is about 1.08 (20 ℃); Above-mentioned filtrating is the macroporous adsorptive resins of 10L through volume, and with the deionized water or the distilled water eluting of 10 times of resin column volumes, 95% ethanol elution of 5 times of resin column volumes of reuse is collected ethanol elution, removes solvent, obtains the component medicine earlier; Incapsulate and be made as capsule, every capsules dress 0.3g.Can per 12 be a plate.

The manufacturing process of tablet of the present invention is: with Radix Codonopsis 300g, and Radix Salviae Miltiorrhizae 300g, Flos Carthami 300g, Rhizoma Cyperi 300g, Radix Bupleuri 300g; Radix Angelicae Sinensis 300g, Radix Paeoniae Rubra 300g, Fructus Schisandrae Chinensis 300g, Radix Notoginseng 300g, Herba Asari 300g; Radix Angelicae Pubescentis 300g, Radix Ophiopogonis 300g, Radix Astragali 300g, Radix Polygalae 300g, Rhizoma Et Radix Notopterygii 300g; Caulis Spatholobi 300g, Rhizoma Atractylodis 300g, Semen Persicae 300g, Folium Ginkgo 20g, Rhizoma Chuanxiong 300g.Said medicine chopping joins in the multi-function extractor, and the water logging that adds 3000g was steeped 30～40 minutes, decocts after 1.5 hours, and decoction liquor is subsequent use for the first time in taking-up; After the decocting of medicinal residues adding 3000g boils 1 hour, take out decoction liquor for the second time, twice decoction liquor merged filter; Filtrate decompression is concentrated into the solution that ratio of weight and number is 1000g, staticly settles 24～36 hours, draws supernatant; Add starch 3000g after being heated to 40～50 ℃, heating is concentrated into pasty state, puts into baking oven; Be controlled at 80 ℃, oven dry postcooling, film-making, drying, molding, packing.Can each hundred be one bottle of packing.Take each 3 every day three times.

The method for preparing of drop pill of the present invention may further comprise the steps: with Rhizoma Cyperi 1500g, and Herba Asari 1500g, Rhizoma Chuanxiong 1500g and Radix Notoginseng 1500g add the water of 36000g; Put into multi-function extractor; Keep air pressure at 0.04-0.06mPa, decocted 2 hours, extract its water soluble ingredient; Repeat above-mentioned steps and extracted extracting liquid filtering 100 mesh sieves once more 1.5 hours; With the refining filtrating of macroporous adsorbent resin, use ethanol elution; It is 1.33-1.35 that eluent is evaporated to density, and wherein input air pressure is 0.04-0.06mPa, vacuum is-0.076～-0.088mPa, stand for standby use; All the other medical material Radix Codonopsis 1500g, Radix Salviae Miltiorrhizae 1500g, Flos Carthami 1500g, Radix Bupleuri 1500g, Radix Angelicae Sinensis 1500g; Radix Paeoniae Rubra 1500g, Fructus Schisandrae Chinensis 1500g, Radix Angelicae Pubescentis 1500g, Radix Ophiopogonis 1500g; Radix Astragali 1500g, Radix Polygalae 1500g, Rhizoma Et Radix Notopterygii 1500g, Caulis Spatholobi 1500g; Semen Persicae 1500g, Rhizoma Atractylodis 1500g, Folium Ginkgo 500g adds the water of 6 times of amounts of its gross weight sum; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours, extracts its water soluble ingredient; Repeat above-mentioned steps, extracted once more 1 hour; The filter extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate is to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitation liquid filters with 100 mesh sieves; Vacuum concentrated filtrate, admission pressure are 0.04-0.06mPa, and vacuum is 0.076-0.088mPa; The use sephadex chromatography is refining, uses ethanol elution; It is 1.33-1.35 that eluent is concentrated into density, leaves standstill; Get above-mentioned two kinds and leave standstill liquid adding Polyethylene Glycol-6000, mix; The mixture heated fusion; With the drop pill machine mixture is processed compound dripping pill.

Drop pill machine technology parameter is following: the drip irrigation temperature keeps 85-95 ℃, and condensed fluid liquid paraffin temperature is lower than 8 ℃, and the water dropper internal diameter is 1.6mm, and the water dropper external diameter is 2.5mm, and water dropper is 15cm apart from the liquid paraffin surface distance; Centrifugal, rotating speed 800-1100rpm after 15 minutes, removes deparaffnize and gets final product.Be quick acting, drop pill of the present invention is made into to dissolve the piller of absorption in the Sublingual rapidly, and it can go into blood fast, through cardiac muscle, allevating angina pectoris rapidly.

Chinese medicine preparation pharmacodynamic study of the present invention:

1, after the insufficiency of heart-QI model mice was used Chinese medicine preparation of the present invention, the anxiety that suspension is caused had obvious inhibitory action; Prolonged the length of one's sleep; Muscular tension increases, the time lengthening of standing; Adopting the water maze method to record memory increases; Hypoxia endurance time prolongs under the normal pressure; Insufficiency of heart-QI mice heart rate is recovered;

2, after normal mouse was used Chinese medicine preparation of the present invention, the anxiety that forced swimming method and suspension method are caused had tangible sedation; Obviously prolonged the length of one's sleep of mice; Immunologic function is significantly improved, MNP phagocytic index and activate the phagocytic capacity are obviously increased, the mice serum amboceptor significantly raises;

3, the hypertension to neuroendocrine type hypertension model rat has tangible reduction effect; Heart rate obviously recovers; The length of one's sleep, significant prolongation had the obvious synergistic effect with pentobarbital sodium; The test of water maze method is visible, and the memory of rat model is increased, and the time that in the labyrinth, stops obviously shortens; Visible with the head-breaking test, Chinese medicine composition of the present invention obviously prolongs the time of opening one's mouth behind the rat broken end.

Acute toxicity testing:

The oral maximum dosage-feeding of the mice of Chinese medicine composition of the present invention is 210g crude drug/kg, calculates by kg body weight, is equivalent to 1110 times of Coming-of-Age Day consumption 8.8g, presses body surface area and calculates, and is equivalent to 172 times; It is 41.567 crude drugs/kg that intraperitoneal administration records its LD50, its 95% credible 36.124～41.983g crude drug/kg that is limited to.Explain that Chinese medicine preparation oral toxicity of the present invention is low, clinical practice is safer.

Long term toxicity test:

Chinese medicine preparation of the present invention to mice by 7.81,18.34 and the 40.11g crude drug/12 weeks of kg continuous use (1.0ml/100g body weight; Every day 2 times) and after 3 week of drug withdrawal; The result shows: Chinese medicine preparation of the present invention does not all have obvious influence to indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat; The internal organs naked eyes do not find that difference changes and the histological examination result shows that after 12 weeks of medication and 3 weeks of drug withdrawal, each internal organs of rat all do not have obvious change.Explain that toxicity is little after Chinese medicine preparation of the present invention is to the rat long-term prescription, also do not have the difference reaction after the drug withdrawal, application safety.

Clinical experiment:

Clinical data: collect my institute's patients with coronary heart disease 60 examples of in August, 2005～2008 year July, be acute myocardial infarction or angina pectoris, wherein male 34 examples, women 26 examples, 35～72 years old age, average 58 years old.Include standard in: the underwent coronary radiography is made a definite diagnosis, and at 35～72 years old age, male or female meets following condition: 1. acute myocardial infarction or angina pectoris; 2. 2 of coronary angiographies or above main coronary artery>=75% are narrow or inaccessible, at least 1 suitable coronary artery bracket implantation; 3. lesion vessels diameter 2.5～4.0mm, and do not go PTCA in the past; 4. coronary artery bracket length≤25mm; 5. there are not aspirin, heparin, clopidogrel contraindication.Exclusion standard: 1. complication with diabetes; 2. severe cardiac functional defect; 3. acute upper respiratory tract infection; 4. malignant tumor; 5. arteria coronaria lesion vessels length＞25mm; 6. arteria coronaria bifurcated lesions; 7. row aorta-coronary artery bypass grafting (CABG).At random the patient is divided into treatment group and matched group.

1 control methods:

Two groups of patients are according to all conventional fat regulation medicine, anticoagulant, antiplatelet, nitrate esters, beta-blocker, calcium ion blocker, angiotensin-convertion enzyme inhibitor or the angiotensin ii receptor antagonist etc. used of the state of an illness.Behind stent endoprosthesis in the 24h, the treatment group gives Chinese medicinal capsule agent of the present invention every day three times, each two; Matched group only adopts conventional Primary Care.Be 6 months two groups of patients' the course of treatment.

1.2 observation index and method

(1) arteria coronaria side shoot integration: adopt the Digital Subtraction blood vessel to detect the arteria coronaria collateral circulation.The arteria coronaria side shoot is according to international Cohen-Rentrop method method [1]: 0=has no collateral blood vessels; 1=has collateral blood vessels to be poured but does not arrive the visceral pericardium part; The 2=collateral blood vessels partly is filled into visceral pericardium; The 3=collateral blood vessels is filled into visceral pericardium fully.Then point out higher integration if any a plurality of side shoots; Exist the many places side shoot then to select 1 higher branch vessel of integration to calculate if any number branch vessel pathological changes.

(2) stent restenosis: according to the standard shadowgraph technique respectively before PTCA, support insert after at once, insert back 6 months capable coronary angiographies, injection is measured the lumen of vessels internal diameter respectively behind the nitroglycerin in arteria coronaria.

(3) (left ventricular ejection fraction, LVEF): the utilization ultrasonic technique is measured LVEF with simplifying the Simpson formula to the left ventricular ejection mark.

1.3 using SPSS 11.0 statistical softwares, statistical procedures carries out variance analysis, t check and chi-square criterion.

2 results

2.1 arteria coronaria collateral circulation integration and LVEF change when being selected in; Two groups of patients all have less collateral circulation even do not have collateral circulation; But treatment group patient was through 6 months treatment, and arteria coronaria collateral circulation integration is divided by (0.12 ± 0.10) brings up to (2.05 ± 0.1) branch, and LVEF also has improvement; Bring up to (0.51 ± 0.22) by (0.46 ± 0.24); And matched group arteria coronaria collateral circulation integration is only brought up to (1.40 ± 0.11) branch by (0.13 ± 0.12) branch, is (0.45 ± 0.21) before the LVEF treatment, and the treatment back is (0.44 ± 0.22); Arteria coronaria collateral circulation integration behind the treatment group patient treatment all has significance to improve (P＜0.01) with matched group before the treatment, and LVEF significantly improves; Arteria coronaria collateral circulation integration before and after the treatment of control group and LVEF then do not have significance and change (P＞0.05).

2.2 treatment group luminal stenosis percentage rate and matched group relatively there are no significant difference (P＞0.05) before tube chamber and the clinical restenosis situation art, add with treatment group of the present invention after 6 months radiography follow up a case by regular visits to luminal stenosis percentage rate significance reduction (P＜0.01); Clinical restenosis incidence rate is 1 example of treatment group, and matched group 3 examples all give the PCI treatment of success once more, see table 1.

The variation of tube chamber and clinical restenosis before and after the table 1. liang group patient support placement in the treatment (x ± s, n=30)

Embodiment 1: patient Lee, man, 56 years old, hypertension, coronary heart disease medical history 3 years; Once left hospital behind thromboembolism treatment because of suffering from acute myocardial infarction, still have uncomfortable in chest, breathe hard, weak etc., long-term bed can not descend ground movable; The movable slightly back state of an illness increases the weight of, electrocardio diagram old heart infarction, and the ST section changes; Cardiac ultrasonic points out left chamber systolic and diastolic function to go down, and radiography shows coronary atherosclerosis, and blood vessel is seriously narrow; RS takes place later six months in Parallel PC I, adds medicine pill prepared in accordance with the present invention on the conventional therapy basis, uses prescription as follows:

Radix Codonopsis 20g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 20g, Rhizoma Cyperi 20g, Radix Bupleuri 20g, Radix Angelicae Sinensis 15g, Radix Paeoniae Rubra 15g; Fructus Schisandrae Chinensis 10g, Radix Notoginseng 20g, Herba Asari 10g, Radix Angelicae Pubescentis 15g, Radix Ophiopogonis 15g, Radix Astragali 10g, Radix Polygalae 10g; Rhizoma Et Radix Notopterygii 10g, Caulis Spatholobi 15g, Rhizoma Atractylodis 10g, Semen Persicae 15g, Folium Ginkgo 7g, Rhizoma Chuanxiong 20g.

Take every day three times, each four, patient's symptom is clearly better after 50 days.Treat after 5 months ECG ST-T and change obviously and improve, cardiac ultrasonic shows left chamber contractile function near normal, and platelet aggregation obviously is suppressed, and the formation probability of thrombosis reduces, and has prevented thrombosis and restenosis behind the support.Continue to take and consolidate drug withdrawal after the course of treatment, follow up a case by regular visits to do not recur so far in 2 years uncomfortable in chest wait uncomfortable.

Embodiment 2: patients with coronary heart disease, seal certain, woman, 65 years old; Because of the coronary heart disease spontaneous angina pectoris, the medication of nitrate esters coronary dilating is imitated bad, shows coronary stricture through crown radiography, parallel PTCA; The postoperative angina pectoris disappears, but 1 year interior restenosis of after-poppet was once not good with therapeutic effect such as nitroglycerin; Heavy when light during angina pectoris, after add and use treatment by Chinese herbs, use as follows and fill a prescription:

Radix Codonopsis 10g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 20g, Rhizoma Cyperi 20g, Radix Bupleuri 10g, Radix Angelicae Sinensis 15g, Radix Paeoniae Rubra 10g; Fructus Schisandrae Chinensis 10g, Radix Notoginseng 20g, Herba Asari 10g, Radix Angelicae Pubescentis 10g, Radix Ophiopogonis 15g, Radix Astragali 10g, Radix Polygalae 10g; Rhizoma Et Radix Notopterygii 10g, Caulis Spatholobi 10g, Rhizoma Atractylodis 10g, Semen Persicae 15g, Folium Ginkgo 5g, Rhizoma Chuanxiong 20g.Processing honey refining pill takes.Every day three times, each ball.Angina pectoris obviously improves after one month, treats after 3 months, and angina pectoris disappears, and after treatment 3 months is followed up a case by regular visits to and do not seen recurrence so far.

Embodiment 3: the patient Qin, man, 72 years old, coronary disease medical history 5 years, hypertension history 2 years.Sign: heating, still feel cardiopalmus after body temperature is normal, pulse speeds, and pareordia is uncomfortable, and is unable.Auxiliary examination: numeration of leukocyte raises, and ECG ST-T changes, and radiography shows coronary stricture, row PTCA.Postoperative RS, patient add and use treatment by Chinese herbs, use prescription as follows: Radix Codonopsis 15g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 20g, Rhizoma Cyperi 20g; Radix Bupleuri 15g, Radix Angelicae Sinensis 15g, Radix Paeoniae Rubra 10g, Fructus Schisandrae Chinensis 10g, Radix Notoginseng 15g, Herba Asari 15g; Radix Angelicae Pubescentis 10g, Radix Ophiopogonis 20g, Radix Astragali 20g, Radix Polygalae 10g, Rhizoma Et Radix Notopterygii 10g; Caulis Spatholobi 20g, Rhizoma Atractylodis 10g, Semen Persicae 15g, Folium Ginkgo 6g, Rhizoma Chuanxiong 20g.Take medicine pill prepared in accordance with the present invention, take every day three times, each four.Through trimestral treatment, the state of an illness is stablized with becoming, but have that slight cardiac dilatation, cardiac function go down, arrhythmia or electrocardiogram change, through 3 months treatment, patient's symptom took a turn for the better gradually again.

The case of 120 routine PTCA postoperative restenosis is carried out clinical observation, and all cases all meet the related standards of WHO ischemic heart desease.Wherein male 84 examples, women 36 examples; Mean age is 55 years old; Acute myocardial infarction 37 examples, angina pectoris 83 examples, outmoded heart infarction 40 examples of the past, sick 69 examples of complicated hypertension, diabetes 33 examples, hyperlipemia 51 examples.Restenotic lesions 145 places, anterior descending branch 49 places wherein, right Guan54Chu, 26 place of circling round, bridge pathological changes 16 places.A type pathological changes 9 places, Type B pathological changes 103 places, C type pathological changes 33 places, the chronic occlusion sexually transmitted disease (STD) becomes 23 places.Lay support 108 places, wherein balloon expandable 62 places.Tcm syndrome characteristics to PTCA postoperative coronarography check in 6 months demonstration restenosis case are analyzed.Qi-asthenia phlegm blood stasis syndrome 78 examples account for 65% among the 120 routine patients; Deficiency of YIN expectorant blood stasis syndrome 13 examples account for 11%; 29 examples are demonstrate,proved in the internal resistance of the expectorant stasis of blood, account for 24%.The result shows blockage of the cardiac vessels, the blood stasis of blood stagnates be its main diseases because of, uses prescription supporting vital QI and dispersing blood stasis of the present invention, also be the basic pathogenesis of coronary heart disease restenosis after interventional therapy generation.So blood circulation promoting and blood stasis dispelling should be the basic way of control restenosis.The present invention has effects such as blood vessel dilating, blood pressure lowering, microcirculation improvement; Strengthen coronary blood flow and improve myocardial metabolism and strengthen the effect of its contractility, use prescription of the present invention effectively to prevent RS, effective percentage is up to 75%.General patient uses take effect three courses of treatment.

Claims (9)

1. a Chinese medicine preparation of preventing and treating angiocardiopathy stent restenosis is characterized in that, the ratio of weight and number of various crude drug is: 10～30 parts of Radix Codonopsis, 10～30 parts of Radix Salviae Miltiorrhizaes, 10～30 parts on Flos Carthami; 10～30 parts of Rhizoma Cyperis, 10～30 parts of Radix Bupleuri, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Radix Paeoniae Rubra, 10～30 parts of Fructus Schisandrae Chinensis; 10～30 parts of Radix Notoginseng, 10～30 parts of Herba Asaris, 10～30 parts of Radix Angelicae Pubescentiss, 10～30 parts of Radix Ophiopogonis; 10～30 parts of the Radixs Astragali, 10～30 parts of Radix Polygalaes, 10～30 parts of Rhizoma Et Radix Notopterygiis, 10～30 parts of Caulis Spatholobis; 10～30 parts of Rhizoma Atractylodis, 10～30 parts in Semen Persicae, 5～10 parts of Folium Ginkgos, 10～30 parts of Rhizoma Chuanxiongs.

2. according to the Chinese medicine preparation of the said control angiocardiopathy stent restenosis of claim 1, it is characterized in that the ratio of weight and number of various crude drug is: 10～15 parts of Radix Codonopsis, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts on Flos Carthami; 10～15 parts of Rhizoma Cyperis, 10～15 parts of Radix Bupleuri, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of Fructus Schisandrae Chinensis; 10～20 parts of Radix Notoginseng, 10～20 parts of Herba Asaris, 10～20 parts of Radix Angelicae Pubescentiss, 10～20 parts of Radix Ophiopogonis; 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Polygalaes, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～20 parts of Caulis Spatholobis; 10～20 parts of Rhizoma Atractylodis, 10～20 parts in Semen Persicae, 5～10 parts of Folium Ginkgos, 10～20 parts of Rhizoma Chuanxiongs.

3. according to the Chinese medicine preparation of the said control angiocardiopathy stent restenosis of claim 1, it is characterized in that the ratio of weight and number of various crude drug is: 10～20 parts of Radix Codonopsis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts on Flos Carthami; 10～20 parts of Rhizoma Cyperis, 10～20 parts of Radix Bupleuri, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Fructus Schisandrae Chinensis; 10～15 parts of Radix Notoginseng, 10～15 parts of Herba Asaris, 10～15 parts of Radix Angelicae Pubescentiss, 10～15 parts of Radix Ophiopogonis; 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Polygalaes, 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Caulis Spatholobis; 10～15 parts of Rhizoma Atractylodis, 10～15 parts in Semen Persicae, 5～10 parts of Folium Ginkgos, 10～15 parts of Rhizoma Chuanxiongs.

4. according to the Chinese medicine preparation of the said control angiocardiopathy stent restenosis of claim 1, it is characterized in that the ratio of weight and number of various crude drug is: 15～25 parts of Radix Codonopsis, 15～25 parts of Radix Salviae Miltiorrhizaes, 15～25 parts on Flos Carthami; 15～25 parts of Rhizoma Cyperis, 15～25 parts of Radix Bupleuri, 15～25 parts of Radix Angelicae Sinensis, 15～25 parts of Radix Paeoniae Rubra, 15～25 parts of Fructus Schisandrae Chinensis; 15～25 parts of Radix Notoginseng, 15～25 parts of Herba Asaris, 15～25 parts of Radix Angelicae Pubescentiss, 15～25 parts of Radix Ophiopogonis; 15～25 parts of the Radixs Astragali, 15～25 parts of Radix Polygalaes, 15～25 parts of Rhizoma Et Radix Notopterygiis, 15～25 parts of Caulis Spatholobis; 15～25 parts of Rhizoma Atractylodis, 15～25 parts in Semen Persicae, 5～10 parts of Folium Ginkgos, 15～25 parts of Rhizoma Chuanxiongs.

5. according to the Chinese medicine preparation of each said control angiocardiopathy stent restenosis in the claim 1～4, it is characterized in that the dosage form of said Chinese medicine preparation is: honey refining pill, hydration pill, capsule, oral liquid, tablet, drop pill or syrup.

6. the method for preparing like the Chinese medicine preparation of each said control angiocardiopathy stent restenosis in the claim 1～4 is characterized in that, the dosage form of said Chinese medicine preparation is a honey refining pill, and its preparation method may further comprise the steps:

Said crude drug was soaked 30 minutes to 1 hour, and heated and boiled 30 minutes is filtered filtrate for later use; Filtering residue adds water, and heating was boiled 30 minutes for the second time, refiltered filtrate for later use; Filtering residue adds water again, and heated and boiled is 40 minutes for the third time, filters; Three filtratings are lumped together, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, dries postcooling, and mixing with Mel is twisted into slice, pill wax seal packing.

7. the method for preparing like the Chinese medicine preparation of each said control angiocardiopathy stent restenosis in the claim 1～4 is characterized in that, the dosage form of said Chinese medicine preparation is a capsule; Its preparation method may further comprise the steps: said crude drug is added 10 times of amounts of weight ethanol, heating and refluxing extraction 3 times, each 2 hours; 3 extracting solution are merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL; Behind the sucking filtration, when the relative density of filtrating is 20 ℃ 1.08; Said filtrate flow is the adsorption resin column of 10L through volume, uses the deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, 95% ethanol elution of 5 times of resin column volumes of reuse; Collect ethanol elution; Remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule.

8. method for preparing like the Chinese medicine preparation of each said treatment control angiocardiopathy stent restenosis in the claim 1～4; It is characterized in that; Said Chinese medicine preparation dosage form is a tablet, and its preparation method may further comprise the steps: said medicine chopping is joined in the multi-function extractor, and the adding ratio of weight and number is that 3000 parts water logging was steeped 30～40 minutes; Decoct after 1.5 hours, decoction liquor is subsequent use for the first time in taking-up; Medicinal residues adding ratio of weight and number is after 3000 parts decocting boils 1 hour, to take out decoction liquor for the second time, aforementioned twice decoction liquor is merged filter; It is 1000 parts solution that filtrate decompression is concentrated into ratio of weight and number, staticly settles 24～36 hours, draws supernatant; Add starch after being heated to 40～50 ℃, heating is concentrated into pasty state, puts into baking oven; Be controlled at 80 ℃, oven dry postcooling, film-making, drying, molding, packing.

9. the method for preparing like the Chinese medicine preparation of each said treatment control angiocardiopathy stent restenosis in the claim 1～4 is characterized in that said Chinese medicine preparation dosage form is a drop pill; Its preparation method may further comprise the steps: compare Rhizoma Cyperi according to said crude drug; Herba Asari, Rhizoma Chuanxiong and Radix Notoginseng add the water that its weight sum 5-7 doubly measures, and put into multi-function extractor; Keep air pressure at 0.04-0.06mPa, decocted 2 hours; Repeat above-mentioned steps and extracted extracting liquid filtering 100 mesh sieves once more 1.5 hours; With the refining filtrating of adsorbent resin, use ethanol elution; Eluent is evaporated to density 1.33-1.35, input air pressure 0.04-0.06mPa wherein, and vacuum is-0.076～-0.088mPa, stand for standby use; All the other crude drug add the water that its weight sum 5-7 doubly measures, and put into multi-function extractor, and maintenance air pressure is 0.04-0.06mPa, decocts 2 hours; Repeating abovementioned steps extracted 1 hour once more; Extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate is to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitation liquid filters with 100 mesh sieves; Vacuum concentrated filtrate, admission pressure are 0.04-0.06mPa, and vacuum is 0.076-0.088mPa; The use sephadex chromatography is refining, uses ethanol elution; It is 1.33-1.35 that eluent is concentrated into density, leaves standstill; Get above-mentioned two kinds and leave standstill liquid adding Polyethylene Glycol-6000, mix; The mixture heated fusion; With the drop pill machine mixture is processed compound dripping pill.