CN102406799A

CN102406799A - Cataplasm paste for treating diabetes and hypertension complicated with coronary heart disease and preparation method thereof

Info

Publication number: CN102406799A
Application number: CN201110382295XA
Authority: CN
Inventors: 王令喜; 王东刚
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-11-08
Filing date: 2011-11-08
Publication date: 2012-04-11

Abstract

The invention relates to cataplasm paste for treating diabetes and hypertension complicated with coronary heart disease and a preparation method thereof. The cataplasm is prepared from acanthopanax, Chinese wolfberry, prepared rehmannia root, Chinese yam, cornel, American ginseng, radix bupleuri, rhizoma corydalis, salvia miltiorrhiza, rhizoma ligustici wallichii, tree peony bark, pseudo-ginseng, dragon blood, evonymus alata, earthworm, leeches, motherwort dew, siegesbeckia orientalis, artificial cow-bezoar, buffalo horn, clam shell, alisma, fructus evodiae, kudzu root, cassia seed, bombys batryticatus, borneol, storax, astragalus mongholicus, poria, mulberry dew, epimedium, deerhorn glue, glue of tortoise plastron, menthol and artificial musk according to preparation methods of decocting by fire, pulverizing, stirring and the like. The cataplasm can effectively treat diabetes and hypertension complicated with coronary heart disease, has the advantages of rapid action, no anaphylactic reaction and significant treatment effect, and can well tonify Yin and Yang as well as qi and blood.

Description

Crust cloth cream of the concurrent coronary heart disease of treatment diabetic hypertension and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, particularly a kind of crust cloth cream of treating the concurrent coronary heart disease of diabetic hypertension the invention still further relates to the method for preparing of this crust cloth cream.

Background technology

The concurrent coronary heart disease of diabetic hypertension is that common in older people is sick, frequently-occurring disease and the disease that is associated, and etiology and pathology is roughly the same, and the cause of disease is the too urgent 3. 4. cold temperature discomfort of eating and drinking without temperance of 2. overworking of feelings will 1.; Pathogenesis is a deficiency in origin and excess in superficiality, and deficiency syndrome mingling with excess syndrome, deficiency in origin are cloudy gas two void, and mark is real to be the scorching malicious phlegm-damp blocking meridian of blood stasis; Deficiency of YIN dampness, yang hyperactivity causes diabetic hypertension; The deficiency of YIN is evil contains, and the stasis of blood hinders crown arteries and veins blood supply oxygen supply obstacle, and cardiac damage causes coronary heart disease.Therapeutic Method is that operation can only be alleviated with blood sugar lowering, blood pressure lowering, the treatment of blood fat reducing centering sedative with interim at that time, is prone to recurrence, gets and often takes medicine for a long time, is prone to produce a lot of untoward reaction.Prophylactic treatment and anti-recurrence are this sick most important tasks of treatment." the Gansu traditional Chinese medical science " magazine the volume 5 phase Shi Gang Master degree candidates of Hunan College of Traditional Chinese Medicine " hypertension traditional Chinese medical science progress " Mays 17 in 2004 point out: the hypertension sickness rate is the rising balance of power; Lapse to seriously, finally more than cardiovascular and cerebrovascular disease, renal failure; Age of onset the young and the middle aged increases; The Western medicine blood pressure lowering has many limitation, and external treatment of Chinese medicine is classified as first-selected therapy by World Health Organization (WHO), has advantage easy, that effect does not have side reaction.Chinese traditional treatment is edited like " Chinese materia medica ": 985 pages of the positive magnificent People's Health Publisher of face the 1st edition the 2nd printings in the 1st edition August nineteen ninety-five June in 1991, LIUWEI DIHUANG WAN is formed [effect and pharmacology] nourishing the liver and kidney, benefit marrow, blood sugar lowering, the blood supply of blood pressure lowering increase coronary artery, arrhythmia, anti-stress treatment diabetes, hypertension, cardiovascular system diseases, coronary heart disease by Radix Rehmanniae Preparata, dried Rhizoma Dioscoreae, Fructus Corni, Rhizoma Alismatis, Poria, Cortex Moutan.Blood pressure lowering external application spirit (being processed into cream by Rhizoma Chuanxiong, Radix Et Rhizoma Rhei etc.) for another example, the two Yongquan acupoint of external application also can effectively be treated concurrent coronary heart disease.Curative effect is low, slow shortcoming takes effect but above-mentioned treatment by Chinese herbs exists.

Summary of the invention

The object of the present invention is to provide a kind of crust cloth cream of treating the concurrent coronary heart disease of diabetic hypertension, curative effect is high, instant effect; The present invention also provides a kind of method for preparing this crust cloth cream for this reason.

The present invention is achieved in that

The crust cloth cream of the concurrent coronary heart disease of treatment diabetic hypertension is characterized in that the component of processing effective ingredient by its weight proportion is: Radix Et Caulis Acanthopanacis Senticosi 25～35, Fructus Lycii 25～35, Radix Rehmanniae Preparata 18～22, Rhizoma Dioscoreae 18～22, Fructus Corni 18～22, Radix Panacis Quinquefolii 18～22, Radix Bupleuri 16～20, Rhizoma Corydalis 16～20, Radix Salviae Miltiorrhizae 16～20, Rhizoma Chuanxiong 16～20, Cortex Moutan 16～20, Radix Notoginseng 4～8, Sanguis Draxonis 1～5, Ramulus Euonymi 16～20, Pheretima 4～8, Hirudo 4～8, Herba Leonuri dew 16～20, uncommon Herba Siegesbeckiae 16～20, artificial Calculus Bovis 0.3～0.6, Cornu Bubali 4～8, Concha Meretricis seu Cyclinae 4～8, Rhizoma Alismatis 14～18, Fructus Evodiae 4～8, Radix Puerariae 14～18, Semen Cassiae 14～18, Bombyx Batryticatus 4～8, Borneolum Syntheticum 2～6, Styrax 4～8, the Radix Astragali 12～16, Poria 12～16, Fructus Mori dew 16～20, Herba Epimedii 12～16, Colla cornus cervi 25～45, Colla Plastri Testudinis 25～35, Mentholum 2～5 and artificial Moschus 0.1～0.4.

The method for preparing of the crust cloth cream of the concurrent coronary heart disease of treatment diabetic hypertension may further comprise the steps:

(1) by weight taking by weighing Radix Et Caulis Acanthopanacis Senticosi, Fructus Lycii, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Radix Panacis Quinquefolii, Radix Bupleuri, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Cortex Moutan, Ramulus Euonymi, Herba Siegesbeckiae, Rhizoma Alismatis, Radix Puerariae, Semen Cassiae, the Radix Astragali, Poria, Herba Epimedii, going into altogether in the jacketed pan, is that 1: 3 ratio adds water in the weight ratio of medicine and water; Endure with slow fire and to boil back 60 minutes; Medicine is pulled out, medicinal liquid with 100 order sieve impurity screenings after, reenter in the jacketed pan to endure and drip into pearl with slow fire; Process Chinese medical concrete, subsequent use;

(2) by weight taking by weighing Radix Notoginseng, Fructus Evodiae, Styrax, Cornu Bubali, Bombyx Batryticatus, Pheretima, Hirudo, Concha Meretricis seu Cyclinae, electric mill is pulverized, and filters with 100 order sieve, processes the Chinese medicine fine powder, and is subsequent use;

(3) by weight taking by weighing Borneolum Syntheticum, Mentholum, artificial Calculus Bovis, artificial Moschus, be ground into porcelain respectively and fly fine powder, deposit sealing in the porcelain vase respectively in, subsequent use;

(4) by weight taking by weighing Colla cornus cervi, Colla Plastri Testudinis, electric mill becomes coarse powder, go in the jacketed pan, and be that 1: 10 ratio adds water in the weight ratio of medicine and water, endured 60 minutes with slow fire, hot candied to pick up glue with hands like the silkworm silk shape, one-tenth animal glue cream, subsequent use;

(5) obtain Herba Leonuri dew, Fructus Mori dew, subsequent use;

(6) get the above-mentioned Chinese medical concrete of producing, Chinese medicine fine powder, fly that fine powder, animal glue cream, Herba Leonuri reveal, Fructus Mori reveals; Put into blender and stirred 20 minutes, to fine and smooth evenly one-tenth ointment, ointment is coated onto on the elastic force cloth with coating machine; 0.4 millimeter of thickness, the finished product that is cut to 3 * 5cm with cutting machine clings to cloth cream.

After the present invention adopts such scheme; By water solublity Chinese medical concrete, Chinese medicine fine powder, fly fine powder and animal glue is formulated; With animal glue is substrate; Overcome traditional black plaster and rubber plaster and soaked Chinese medicine, volatile drug effect, lowered curative effect and add adjuvant Plumbum preparatium and cause that poisoning by aluminum, adhesive plaster with medicine add adjuvant zinc oxide defective hypersensitive with fried Chinese medicine of high temperature and ethanol.Animal glue substrate and human body have the affinity interaction efficacy of a drug to absorb fast, instant effect, the irritated reaction of nothing, and simultaneously big nourishing YIN sun, QI and blood are evident in efficacy.

Pharmacology analysis

Blood sugar lowering is answered in the treatment of the concurrent coronary heart disease of diabetic hypertension, blood pressure lowering, and blood fat reducing increases crown arteries and veins blood supply and insulin secretion, improves and repairs cardiac damage and the disorderly Zhi Qiben of insulin function; Eliminating evil (soothing liver-QI for relieving depression, regulating qi to disperse stagnation, the meridian dredging, heat-clearing and toxic substances removing, drying dampness to eliminate phlegm sending down the abnormal ascending QI bloody sputum is turbid descending; Relieving muscles diaphoresis promoting the production of body fluid to quench thirst, suppressing the hyperactive liver to relieve the wind syndrome, nourishing YIN for suppressing the hyperactive YANG, clearing away heart-fire for tranquillization, causing resuscitation with aromatic drugs refreshment) tonify deficiency sets upright (nourishing YIN kidney tonifying; Air making-up and spleen enlivening, the suppressing the hyperactive liver of enriching blood, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization, promptly big YIN, YANG and QI tonifying blood; Tonify deficiency is set upright Zhi Qigen, makes " healthy energy internal memory, heresy can not be done ", and more the back is difficult for recurrence.

The present invention clings to the cloth cream base in the comprehensively correct understanding of modern Chinese medicine to the concurrent coronary heart disease of diabetic hypertension, and the Therapeutic Principle has embodied blood sugar lowering, blood pressure lowering, blood fat reducing and increased coronary artery blood supply and insulin secretion; Improve and repair cardiac damage and insulin function disorder; Zhi Qiben reuses Radix Et Caulis Acanthopanacis Senticosi, Fructus Lycii and is monarch, increases coronary artery blood supply and insulin secretion with blood sugar lowering, blood pressure lowering, blood fat reducing; Improve and repair cardiac damage and insulin function disorder; But Radix Et Caulis Acanthopanacis Senticosi blood sugar lowering viscosity, blood sugar lowering, blood fat reducing, blood vessel dilating, microcirculation improvement effect, the sensitivity of insulin when improving receptor; The insulin circulation is increased, blood supply improvement and insulin secretion are increased.Minister is with Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Radix Panacis Quinquefolii; With the benefiting essence and marrow of nourishing YIN Yiyang, astringent or styptic treatment for spontaneous sweating, air making-up and spleen enlivening, the suppressing the hyperactive liver of enriching blood, clearing away heart-fire for tranquillization, nourishing YIN and moistening the lung; Blood sugar lowering, blood pressure lowering, blood fat reducing and increase coronary artery blood supply and insulin secretion improve and repair cardiac damage and insulin function disorder.Herba Siegesbeckiae is revealed, wished to assistant with Radix Bupleuri, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Cortex Moutan, Radix Notoginseng, Sanguis Draxonis, Ramulus Euonymi, Pheretima, Hirudo, the Herba Leonuri of soothing liver-QI for relieving depression, promoting the circulation of blood gas, blood stasis dispelling, the meridian dredging.Assistant helps the monarch and his subjects' blood sugar lowering, blood pressure lowering, blood fat reducing and increases coronary artery blood supply and insulin secretion, improves and repairs cardiac damage and insulin function disorder.With heat-clearing and toxic substances removing removing heat from blood suppressing the hyperactive liver drying dampness to eliminate phlegm, the sending down the abnormal ascending QI bloody sputum is turbid descending, inducing resuscitation with artificial Calculus Bovis, Cornu Bubali, Concha Meretricis seu Cyclinae, Rhizoma Alismatis, Radix Puerariae, Semen Cassiae, Fructus Evodiae, Bombyx Batryticatus, Styrax, Borneolum Syntheticum for assistant).Assistant is set upright " make the healthy energy internal memory, heresy can not be done " pain with the Radix Astragali, Poria, Fructus Mori dew, Herba Epimedii, Colla Plastri Testudinis, Colla cornus cervi with big YIN, YANG and QI tonifying blood tonify deficiency and more is difficult for recurrence in the back.Skilful use Mentholum, artificial Moschus are for making, and the hot cold of Mentholum is dispersed, and the clear sharp head goes into skin and absorbs.

In the above prescription of the present invention Poria is arranged, Rhizoma Alismatis, Cortex Moutan, Radix Rehmanniae Preparata; Rhizoma Dioscoreae, Fructus Corni is formed LIUWEI DIHUANG WAN, its effect and pharmacology: nourishing the liver and kidney is to Liver and kidney spleen three cloudy and benefits, and it is main blood sugar lowering that replenishing kidney-YIN is mended marrow; Blood pressure lowering, blood fat reducing, arrhythmia, atherosclerosis.

Among the present invention:

Fructus Lycii: sweet in the mouth property is flat, effect and pharmacology: enriching yin boost qi, and strengthening the body resistance, spermatogenesis is supporing yang, the lung moistening suppressing the hyperactive liver makes eye bright, and increases specificity and nonspecific immunity, protects the liver hemopoietic, anti-stress effect, blood sugar lowering, blood pressure lowering, blood fat reducing and cholesterol reducing.

Radix Bupleuri: bitter in the mouth cold nature, effect and pharmacology: soothing liver-QI for relieving depression, promotion immunologic function, blood fat reducing.

Rhizoma Corydalis: the bitter in the mouth suffering is warm in nature, effect and pharmacology: regulating QI to relieve pain, blood circulation promoting and blood stasis dispelling, the increase coronary artery blood supply oxygen-supplying amount of bleeding, protection cardiac muscle, treatment coronary heart disease, angina pectoris.

Radix Salviae Miltiorrhizae: bitter in the mouth is slightly cold, effect and pharmacology: blood circulation promoting and blood stasis dispelling, increase the coronary artery blood supply oxygen-supplying amount of bleeding, myocardial ischemia, infarction are had protective effect, microcirculation improvement, blood pressure lowering, blood fat reducing, atherosclerosis, reducing blood viscosity.Treat coronary heart disease, myocardial infarction, pulmonary heart disease, nourishing blood to tranquillize the mind, improve the islets of langerhans microcirculation.

Rhizoma Chuanxiong: acrid in the mouth is warm in nature, effect and pharmacology: blood-activating and qi-promoting, increase the coronary artery blood supply of bleeding, the infringement of protection myocardial ischemia, allevating angina pectoris, improve electrocardiogram, blood pressure lowering, blood fat reducing, cholesterol reducing.

Cortex Moutan: the bitter in the mouth suffering is cold in nature, effect and pharmacology: clearing away heat and cooling blood,, blood circulation promoting and blood stasis dispelling, blood pressure lowering, resisting myocardial ischemia, arrhythmia, anti-heart bolt, and atherosclerosis, sedation and analgesia.

Radix Notoginseng: sweet-bitter flavor is warm in nature; Effect and pharmacology: removing stasis to stop bleeding, ease pain, enrich blood invigorate blood circulation, hemopoietic is calmed the nerves, haemolysis, the crown arteries and veins of expansion; Increase coronary artery blood supply flow, arrhythmia, minimizing myocardial ischemia, blood pressure lowering, blood sugar lowering, immunoregulation effect is arranged, anti-deficient.

Sanguis Draxonis: bitter in the mouth is acid flat, effect and pharmacology: the removing stasis to stop bleeding pain relieving, improve increasing blood flow, increase the coronary artery blood supply, improve myocardial function, myocardial ischemia infringement, arrhythmia.

Ramulus Euonymi: bitter in the mouth is cold in nature, and effect and pharmacology: removing blood stasis stimulates the menstrual flow, and modern pharmacological research has the β of stimulation hyperplasia and promotes that insulin divides effect secret, blood sugar lowering.

Pheretima: salty in the mouth is cold in nature, effect and pharmacology: flat hot endogenous wind stopping, collateral dredging diuresis, blood pressure lowering cure mainly hypertension.

Hirudo: salty in the mouth is cold in nature, specially goes into the blood system part of not feeling frustrated, pharmacological research blood pressure lowering, blood fat reducing, blood sugar lowering.

Herba Leonuri reveals: the bitter in the mouth cold nature, effect and pharmacology: blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema, resisting myocardial ischemia, increase coronary artery blood supply flow and blood supply of cardiac muscle, antithrombotic, blood sugar lowering viscosity promote arteriole blood flow reducing blood pressure and blood fat.

Uncommon Herba Siegesbeckiae: the bitter in the mouth suffering is cold in nature, effect and pharmacology: the wind-damp dispelling the meridian dredging, and heat-clearing and toxic substances removing, the invigorating the liver and kidney benefiting essence-blood, blood pressure lowering, the vasodilator antiinflammatory has immunoregulation effect, cures mainly hypertension.

The artificial Calculus Bovis: bitter but sweet flavor is cool in nature, effect and pharmacology: removing heat from the heart to restore the consciousness suppressing the hyperactive liver to relieve the wind syndrome, heat-clearing and toxic substances removing, calm heart tonifying blood pressure lowering, anticoagulation, the analgesia of eliminating the phlegm.

Cornu Bubali: bitter in the mouth is cold in nature, effect and pharmacology: heat-clearing and toxic substances removing, removing heat from blood arresting convulsion heart tonifying, blood pressure lowering, blood fat reducing, cholesterol reducing.

Concha Meretricis seu Cyclinae: function expectorant blood stasis dispelling institute carbonated has blood sugar lowering, and the function of human body effect is regulated in blood fat reducing.

Rhizoma Alismatis: sweet in the mouth is cold in nature, effect and pharmacology: promoting diuresis to eliminate damp pathogen blood fat reducing, blood pressure lowering, blood sugar lowering, atherosclerosis antithrombotic.

Radix Puerariae: the acrid in the mouth bitterness is cool, and effect and pharmacology: expelling pathogenic factors from muscles for reducing heat promoting the production of body fluid to quench thirst, blood circulation and channel invigorating fall to sugared blood pressure lowering arrhythmia, expand crown arteries and veins, protection ischemic myocardium, blood fat reducing, cholesterol reducing anti-hypoxia.

Semen Cassiae: sweet-bitter flavor is slightly cold, effect and pharmacology: the liver heat removing and eyesight improving nourishing YIN for suppressing the hyperactive YANG cures mainly the excessive rising of liver-YANG vertigo, modern study: blood fat reducing, cholesterol reducing cures mainly hypertension, hyperlipemia disease.

Fructus Evodiae: sweet-bitter flavor is hot in nature, effect and pharmacology: dispersing cold for relieving pain, and drying dampness to eliminate phlegm, cardiotonic, the blood pressure lowering antithrombotic forms tranquillizing and allaying excitement.

Bombyx Batryticatus: salty in the mouth suffering property is flat, and effect and pharmacology: blood stasis-eliminating and stagnation-dissipating dispels the wind and alleviates pain, anticoagulation, blood sugar lowering.

Soviet Union closes: fragrance is hot fragrant warm in nature, effect and pharmacology: sensiblely ward off dirtyly, the dissipating depression of QI eliminating phlegm is usually used in cardiovascular and cerebrovascular disease, and decreased heart rate improves the fibrinolytic acid activity.

Borneolum Syntheticum: the acrid in the mouth bitterness is cold, effect and pharmacology: the pain relieving of having one's ideas straightened out, clearing heat, releasing toxin, removing swelling, oxygen lack resistant function cure mainly calentura coma attacked by pestiferous factors stupor.

The Radix Astragali: sweet in the mouth is warm in nature, effect and pharmacology: invigorating the spleen and replenishing QI, the QI invigorating row blood stasis removing eliminating stagnation qi-supplementing, blood-engendering that stagnates helps blood circulation promoting and blood stasis dispelling, and the meridian dredging medicine increases the curative effect effect, and crown arteries and veins blood supply oxygen supply improves the cardiac damage restitution, cures mainly the interior-heat diabetic coronary artery disease of quenching one's thirst.

Poria: slightly sweet flavor property is flat, effect and pharmacology: invigorating spleen for diuresis, mind tranquilizing and the heart calming, blood sugar lowering.

Fructus Mori reveals: sweet in the mouth is cold in nature, effect and pharmacology: nourishing YIN and supplementing blood, and promoting the production of body fluid to quench thirst, loosening bowel to relieve constipation cures mainly Tianjin wound and quenches one's thirst, the diabetes deficiency of the liver and kindey deficiency of YIN-blood vertigo, dim eyesight tinnitus insomnia hypertension.

Herba Epimedii: acrid-sweet flavor is warm in nature, effect and pharmacology: reinforcing the kidney and supporting YANG expelling wind and removing dampness blood pressure lowering increases crown arteries and veins blood supply microcirculation improvement blood fat reducing blood sugar lowering.

Colla Plastri Testudinis: sweet-salty is cold in nature, effect and pharmacology: lung is supported in the nourish blood reinforcing the heart YIN nourishing of enriching blood of nourishing YIN for suppressing the hyperactive YANG, cures mainly lung-heat and quenches one's thirst, the fidgety cardiopalmus of the deficiency of YIN.

The artificial Moschus: causing resuscitation with aromatic drugs, blood-activating analgetic is gone into the deep absorption of skin; Carry all medicines of neck altogether and go into through sick blood sugar lowering, blood pressure lowering, the blood fat reducing of playing altogether of skin absorption, increase coronary artery blood supply and insulin secretion, it is disorderly to improve reparation cardiac damage and insulin function; Zhi Qiben; Eliminating evil (soothing liver-QI for relieving depression, regulating qi to disperse stagnation, the meridian dredging, heat-clearing and toxic substances removing, drying dampness to eliminate phlegm, sending down the abnormal ascending QI bloody sputum are turbid descending, relieving muscles diaphoresis, promoting the production of body fluid to quench thirst, suppressing the hyperactive liver to relieve the wind syndrome, nourishing YIN for suppressing the hyperactive YANG, removing heat from blood, clearing away heart-fire for tranquillization, hot cool fragrance, inducing resuscitation), tonify deficiency is set upright (the strongly invigorating QI and blood negative and positive make " healthy energy internal memory; heresy can not be done ") disease and is early dispelled, and more the back is difficult for recurrence.

The specific embodiment

Below in conjunction with embodiment the present invention is elaborated.

Embodiment 1

Get the clean Chinese crude drug of following weight:

Radix Et Caulis Acanthopanacis Senticosi 3000g; Fructus Lycii 3000g; Radix Rehmanniae Preparata 2000g; Rhizoma Dioscoreae 2000g; Fructus Corni 2000g; Radix Panacis Quinquefolii 2000g; Radix Bupleuri 1800g; Rhizoma Corydalis 1800g; Radix Salviae Miltiorrhizae 1800g; Rhizoma Chuanxiong 1800g; Cortex Moutan 1800g; Radix Notoginseng 600g; Sanguis Draxonis 300g; Ramulus Euonymi 1800g; Pheretima 600g; Hirudo 600g; Herba Leonuri reveals 1800g; Uncommon Herba Siegesbeckiae 1800g; Artificial Calculus Bovis 50g; Cornu Bubali 600g; Concha Meretricis seu Cyclinae 600g; Rhizoma Alismatis 1600g; Fructus Evodiae 600g; Radix Puerariae 1600g; Bombyx Batryticatus 600g; Semen Cassiae 1600g; Borneolum Syntheticum 300g; Styrax 600g; Radix Astragali 1400g; Poria 1400g; Fructus Mori reveals 1800g; Herba Epimedii 1400g; Colla cornus cervi 3000g; Colla Plastri Testudinis 3000g; Mentholum 300g and artificial Moschus 20g.

Method for preparing:

The first step: get Radix Et Caulis Acanthopanacis Senticosi, Fructus Lycii, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Radix Panacis Quinquefolii, Radix Bupleuri, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Cortex Moutan, Ramulus Euonymi, Herba Siegesbeckiae, Rhizoma Alismatis, Radix Puerariae, Semen Cassiae, the Radix Astragali, Poria, the Herba Epimedii of above-mentioned weight, put in the jacketed pan; In the weight ratio of medicine and water is that 1: 3 ratio adds water 75200g.Endure with slow fire and to boil back 30 minutes, medicine is pulled out, behind 100 order sieve impurity screenings, medicinal liquid reenters in the jacketed pan, endures with slow fire and drips into pearl and be advisable, and processes Chinese medical concrete, puts into stainless-steel pan after the cooling, and is subsequent use.

Second step: get Radix Notoginseng, Pheretima, Hirudo 600g, Cornu Bubali, Concha Meretricis seu Cyclinae, Fructus Evodiae, Bombyx Batryticatus, the Styrax of above-mentioned weight, shared electric mill is pulverized, and filters into fine powder with 100 order sieve, puts into stainless-steel pan, and is subsequent use.

The 3rd step: get the artificial Calculus Bovis, artificial Moschus, Borneolum Syntheticum, Mentholum of above-mentioned weight, be ground into porcelain and fly fine powder respectively, deposit sealing in the porcelain vase respectively in, subsequent use.

The 4th step: get Colla Plastri Testudinis, the Colla cornus cervi of above-mentioned weight, shared electric mill powder coarse powder is gone in the jacketed pan; In the weight ratio of medicine and water is that 1: 10 ratio adds water 600000g, endures 30 minutes with slow fire, and glue is hot candied is advisable like the silkworm silk shape to picking up with hands, and one-tenth animal glue cream is put into stainless-steel pan after the cooling, subsequent use.

The 5th step: the Herba Leonuri of getting above-mentioned weight reveals, Fructus Mori reveals, and is subsequent use.

Herba Leonuri reveals decoction method: before and after the beginning of autumn, extract the root Herba Leonuri in the flowers are in blossom, wash and put into jacketed pan; In the weight ratio of medicine and water is that 1: 2 ratio adds water; Endure with slow fire and to boil back 30 minutes, medicine is pulled out, medicinal liquid with 100 order sieve impurity screenings after; Medicinal liquid reenters in the jacketed pan, endures with slow fire and drips into pearl.

Fructus Mori reveals decoction method: before and after the Beginning of summer, win Fructus Mori in the fruit maturation, wash and put into jacketed pan; In the weight ratio of medicine and water is that 1: 2 ratio adds water; Endure with slow fire and to boil back 30 minutes, Fructus Mori is pulled out, medicinal liquid with 100 order sieve impurity screenings after; Medicinal liquid reenters in the jacketed pan, endures with slow fire and drips into pearl.

The 6th goes on foot: fly fine powder, Herba Leonuri dew, Fructus Mori dew to the Chinese medical concrete of obtaining, glue cream, Chinese medicine fine powder, Chinese medicine, go into interior stirring of blender altogether and arrived the even one-tenth of exquisiteness ointment in 20 minutes.

The 7th step: the ointment of obtaining for the 5th step is coated onto on the elastic force cloth with coating machine, and thickness is 0.4 millimeter, is cut into cutting machine with cutting machine and is cut to 3 * 5cm, and 600 are respectively charged in the double-deck aluminium paper sealing bag specification: 6 slices/bag, seal subsequent use.Can prepare the crust cloth cream that the present invention treats the concurrent coronary heart disease of diabetic hypertension.

Therapeutic Method:

By acupuncture point two springs of applying ointment or plaster, two in each 1 of pass, Hsinshu (acupoint), SHENQUE acupoint, each 6, changed 1 time in 2 days, 15 days is 1 course of treatment.

Yongquan acupoint is that nethermost Yu of human body cave is the yin channel cave that crosses, and Neiguan acupoint is that uppermost Yu of human body cave is the yang channel cave that crosses, and two caves are furnished with negative and positive mutually and subsidize mutually; Condition each other; The effect of equilibrium between yin and yang, XINYU acupoint are the master points of heart channel, are that cardiovascular gathers the remittance part; Paste the through heart and brain of this cave efficacy of a drug, it is quick to take effect.SHENQUE acupoint is that the twelve regular channels gathers the remittance part, is that subcutaneous blood capillary is the closeest at most the most shallow, and the efficacy of a drug absorbs the fastest, the fastest part of curative effect.Therefore absorb soon by above point application method, instant effect, curative effect is high.

Embodiment 2

Get the clean Chinese crude drug of following weight:

Radix Et Caulis Acanthopanacis Senticosi 2500g; Fructus Lycii 3500g; Radix Rehmanniae Preparata 1800g; Rhizoma Dioscoreae 2200g; Fructus Corni 1800g; Radix Panacis Quinquefolii 2200g; Radix Bupleuri 1600g; Rhizoma Corydalis 2000g; Radix Salviae Miltiorrhizae 1600g; Rhizoma Chuanxiong 2000g; Cortex Moutan 1600g; Radix Notoginseng 800g; Sanguis Draxonis 100g; Ramulus Euonymi 2000g; Pheretima 400g; Hirudo 800g; Herba Leonuri reveals 1600g; Uncommon Herba Siegesbeckiae 2000g; Artificial Calculus Bovis 30g; Cornu Bubali 800g; Concha Meretricis seu Cyclinae 400g; Rhizoma Alismatis 1800g; Fructus Evodiae 400g; Radix Puerariae 1800g; Bombyx Batryticatus 400g; Semen Cassiae 1800g; Borneolum Syntheticum 200g; Styrax 800g; Radix Astragali 1200g; Poria 1600g; Fructus Mori reveals 2000g; Herba Epimedii 1200g; Colla cornus cervi 2500g; Colla Plastri Testudinis 3500g; Mentholum 500g and artificial Moschus 10g.

Manufacture method is with embodiment 1, but also preparation cost is invented the crust cloth cream of the concurrent coronary heart disease of treatment diabetic hypertension.

Embodiment 3

Get the clean Chinese crude drug of following weight:

Radix Et Caulis Acanthopanacis Senticosi 3500g; Fructus Lycii 2500g; Radix Rehmanniae Preparata 2200g; Rhizoma Dioscoreae 1800g; Fructus Corni 2200g; Radix Panacis Quinquefolii 1800g; Radix Bupleuri 2000g; Rhizoma Corydalis 1600g; Radix Salviae Miltiorrhizae 2000g; Rhizoma Chuanxiong 1600g; Cortex Moutan 2000g; Radix Notoginseng 400g; Sanguis Draxonis 500g; Ramulus Euonymi 1600g; Pheretima 800g; Hirudo 400g; Herba Leonuri reveals 2000g; Uncommon Herba Siegesbeckiae 1600g; Artificial Calculus Bovis 60g; Cornu Bubali 400g; Concha Meretricis seu Cyclinae 800g; Rhizoma Alismatis 1400g; Fructus Evodiae 800g; Radix Puerariae 1400g; Bombyx Batryticatus 800g; Semen Cassiae 1400g; Borneolum Syntheticum 600g; Styrax 400g; Radix Astragali 1600g; Poria 1200g; Fructus Mori reveals 1600g; Herba Epimedii 1600g; Colla cornus cervi 4500g; Colla Plastri Testudinis 2500g; Mentholum 200g and artificial Moschus 40g.

Clinical experiment:

The present invention treats the crust cloth cream curative effect of the concurrent coronary heart disease of diabetic hypertension for checking, and Liaocheng City institute of traditional Chinese medicine has carried out clinical trial in the Shandong Province for applicant in 2007 to 2011.

1, clinical data:

Patients with hypertension all is diagnosed as hypertensive patient's 48 examples in city-level above the People's Hospital diagnosis from Liaocheng City institute of traditional Chinese medicine conditions of patients.

Diagnostic criteria; Select the patient all meet Zhengzhou cardiovascular meeting in 1979 make Evaluation of Diagnostic Criteria of Hypertension and by stages standard be that differential diagnosis in tcm belongs to type of deficiency of YIN leading to hyper activity of YANG or liver-kidney yin deficiency, dialectical standard is according to " the new Chinese medicine clinical research guideline " of Ministry of Public Health promulgation in 1992.

2, criterion of therapeutical effect:

(1) efficacy of antihypertensive treatment standard, the Ministry of Public Health promulgation " Chinese medicine (new drug) clinical research guideline " in 1993 of consulting and carrying out.Produce effects: diastolic pressure decline >=1.3Kpa, and reach normal range or decline >=2.7Kpa, but do not reduce to normal.Effectively: diastolic pressure decline＜1.3Kpa, but reached the normal range or the 1.3～2.5Kpa that descends, but do not drop to normal or systolic pressure decline >=4Kpa, but do not arrive normal.Invalid: blood pressure drops does not reach effective standard.

(2) symptom criterion of therapeutical effect adopts integration method, and 0 minute asymptomatic, and 1 fen symptom light or accidental appearance, heavy when light when symptom was moderate in 2 minutes, symptom was obvious in 3 minutes.Treating the back than total mark decline >=75% before treating is produce effects, and decline >=30%＜75% is effectively, and decline＞30% is invalid.

3, Therapeutic Method:

Test group: with the present invention " the concurrent coronary heart disease crust of treatment diabetic hypertension cloth cream ".Therapeutic Method: by acupuncture point two springs of applying ointment or plaster, two in each 1 of pass, Hsinshu (acupoint), SHENQUE acupoint, changed 1 time 1 course of treatment of first quarter moon in 2 days.

Matched group: adopt Zhu of Nanjing University of Traditional Chinese Medicine to become English, Wang Shenju, Xue Limei the 21st 12 phases of volume of big 2002 November publish thesis, with " Chinese holly Ju Dihuang ball closes ligustrazine injection for treating hypertension 50 examples ".Therapeutic Method: obey 10 of QIJU DIHUANG WANs, every day 3 times, Ligustrazine Hydrochloride Injection 40mg adds that quiet 20 days day 1 time is 1 course of treatment among the 5% glucose injection 250ml, all stops using to the influential other drug of blood pressure during the treatment at every turn.

4, efficacy result

Table 1 test group and matched group are selected case ordinary circumstance comparative analysis table

Basic through X2 check P＞two groups of situation of 0.05 explanation near having comparability.

Not not routine number comparison sheet of hypertension phase before table 2 test group and the treatment of control group

More approaching through X2 check P＞two groups of not routine numbers of phase of 0.05 explanation, have comparability.

Table 3 test group and matched group efficacy of antihypertensive treatment comparative analysis table

Group	The example number	Produce effects	Effectively	Invalid	Total effective rate %
						Matched group	50	15	29	6	88％
Test group	48	20	25	3	93.75％

XP＜0.01, there were significant differences for XXP＜0.05, two a group curative effect total effective rate, and test group is superior to matched group.

Table 4 test group and matched group symptom curative effect comparative analysis table

Group	The example number	Produce effects	Effectively	Invalid	Total effective rate %
						Matched group	50	21	25	4	92％
Test group	26	26	20	2	98.4％

XP＜0.01, there were significant differences for XXP＜0.05 a liang group symptom curative effect total effective rate, and test group is superior to matched group.

Cardinal symptom pneumatosis difference compares (±) table before and after table 5 test group and the treatment of control group

Group	The example number	Matched group	The example number	Test group
					Have a dizzy spell	43	34.25±10.03 ⁺⁺	44	45.16±10.14 ⁺⁺
Headache	32	24.74±9.5 ⁺⁺	33	31.81±8.24 ⁺⁺
					Soreness of the waist and knees	40	30.36±12.44 ⁺⁺	41	44.28±12.08 ⁺⁺
Vexed xerostomia	35	27.85±11.39 ⁺⁺	37	40.15±5.98 ⁺⁺
					Tired insomnia and dreamful sleep	21	12.53±5.25 ⁺⁺	22	19.24±6.76 ⁺⁺
Cardiopalmus	27	20.50±7.55 ⁺⁺	29	25.83±7.53 ⁺⁺
					Tinnitus	16	10.21±4.90 ⁺⁺	18	16.37±4.68 ⁺⁺

There were significant differences that test group is superior to matched group for the comparison of cardinal symptom integration differential before and after XP＜0.01, XXP＜0.05 liang group test and matched group patient treatment.

5, conclusion:

The present invention treats the crust cloth cream of the concurrent coronary heart disease of diabetic hypertension at cure rate, and obvious effective rate obviously is superior to matched group on the effective percentage, so the present invention selects the medicine prescription to prepare method at therapeutic scheme; Manifest science on the usage that hole pressing is applied ointment or plaster, advance, practicality; Advantage is to absorb soon, instant effect, and curative effect is high; Simple for use, receive numerous patients' approval, can apply.

6, concrete case:

Case 1: Dongguan, town, area just outside a city gate, Guan County, Wang Yue English 46 years old address of woman nurses diagnosis and treatment on April 27th, 2009 by the husband, and the husband tells in generation: the recent dizzy headache of wife, vexed xerostomia; Palpitation and insomnia; Hypertension, repeatedly at local hospital hospitalization but normal the criminal, the spy comes diagnosis and treatment.Inspection: the shoulder yellow fur is thick, and the tip of the tongue is dark red, and the tongue limit is blue, and the indentation trace is arranged; The stringy and thready pulse of feeling the pulse, the diastolic pressure 143Kpa that takes blood pressure, systolic pressure 96Kpa is diagnosed as type of deficiency of YIN leading to hyper activity of YANG hypertension; Treatment external application " the concurrent coronary heart disease of diabetic hypertension crust cloth cream " by acupuncture point two springs of applying ointment or plaster, closes Hsinshu (acupoint) in two; Each 1 of SHENQUE acupoint changed 1 time in 2 days, and 15 days is 1 course of treatment.Paste crust cloth cream after 1 hour, the conscious head of patient is nice and cool, and is clear, dizziness headache, and vexed xerostomia, cardiopalmus disappears, and vomiting in second day is felt sick, and insomnia disappears, and after 1 course of treatment, can arrive movable stroll outside the room, and the check blood pressure recovers normal basically, the recuperation treatment of agreeing to go home.Doctor's advice: avoid sweetly, salty, rich food is eaten light food more, eats vegetable and fruit more, like Fructus Crataegi, Fructus Mume, avoids fatigue, anger, and every day, stroll was taken exercise, and visited over 1 year and did not recur again to examination in hospital 1 time in every month.

Case 2: town Yan dike village, Shouzhang, Yanggu County, Zhang Xinmei 58 years old address of woman nurses diagnosis and treatment on August 6th, 2010 by daughter, and daughter tells in generation: mother's recent months is had a headache because of hypertension dizziness, nausea and vomiting, and soreness of waist and knee joint is unable; Fidgety insomnia, at the hospital of locality hospitalization repeatedly, but often recurrence, inspection blood pressure diastolic pressure 150kpa; Systolic pressure 98kpa hopes white and greasy fur, red tip of the tongue, and the tongue limit is purple; Puckery the moistening of feeling the pulse is diagnosed as hypertension of deficiency of yin of liver and kidney type, and treatment external application " the concurrent coronary heart disease of diabetic hypertension crust cloth cream " by acupuncture point two springs of applying ointment or plaster, closes in two; Hsinshu (acupoint), each 1 of SHENQUE acupoint changed 1 time in 2 days, and 15 days is 1 course of treatment.Paste crust cloth cream after 30 minutes, patient feels that the ambition head is unobstructed, and is clear, dizziness headache, nausea and vomiting; Limbs fatigue disappears, and the sleep of having a meal in second day is normal, and the activity of following ground is checked after 15 days freely, and blood pressure is normal basically; Inspection of the tongue white and thin fur, little red, it is slow and strong to feel the pulse, and agrees to leave hospital the treatment of going home.Doctor's advice: eat sweet food less, rich food is eaten the vegetable light food more, eats fruit more, and like Fructus Crataegi, Fructus Mume, Hylocereus undatus etc., feelings will is not too urgent, and take exercise taken a walk more, and every month arrives examination in hospital 1 time, follows up a case by regular visits to over 1 year and do not recur again.

Case 3: the Dongchangfu District Yang Jibai village, Zhang Dongsheng 66 years old address of man nurses diagnosis and treatment on August 18th, 2009 by wife, and wife tells in generation: within the next few days because of overworking and drink often, frequent dizziness headache, the vomiting of feeling sick; Fidgety nervous, to take blood pressure higher at every turn, has an injection and takes medicine; Recurrence always, inspection is taken blood pressure, diastolic pressure 150kpa; Systolic pressure 100kpa, inspection of the tongue thick, yellow and greasy fur is examined rapid and stringy pulse, is diagnosed as type of deficiency of YIN leading to hyper activity of YANG hypertension.Treatment: external application " the concurrent coronary heart disease crust of diabetic hypertension cloth cream " pastes two springs, two interior closing, and Hsinshu (acupoint), each 1 of SHENQUE acupoint, totally 6, changed 1 time in 2 days, 15 days is 1 course of treatment.It is clear to paste after back 50 minutes patient's mind, the vomiting of feeling sick of readme dizziness headache, and fidgety mental confusion disappears, and has a meal in second day, the sleep activity recovers normal, agrees that going home to pacify cure treats.Doctor's advice: the cigarette of giving up alcohol, sweet food, rich food is eaten light vegetable and fruit more, and take exercise taken a walk more, and every month arrives examination in hospital 1 time, visits over 1 year and do not see recurrence.

Claims

1. the crust cloth cream of the concurrent coronary heart disease of treatment diabetic hypertension is characterized in that the component of processing effective ingredient by its weight proportion is: Radix Et Caulis Acanthopanacis Senticosi 25～35, Fructus Lycii 25～35, Radix Rehmanniae Preparata 18～22, Rhizoma Dioscoreae 18～22, Fructus Corni 18～22, Radix Panacis Quinquefolii 18～22, Radix Bupleuri 16～20, Rhizoma Corydalis 16～20, Radix Salviae Miltiorrhizae 16～20, Rhizoma Chuanxiong 16～20, Cortex Moutan 16～20, Radix Notoginseng 4～8, Sanguis Draxonis 1～5, Ramulus Euonymi 16～20, Pheretima 4～8, Hirudo 4～8, Herba Leonuri dew 16～20, uncommon Herba Siegesbeckiae 16～20, artificial Calculus Bovis 0.3～0.6, Cornu Bubali 4～8, Concha Meretricis seu Cyclinae 4～8, Rhizoma Alismatis 14～18, Fructus Evodiae 4～8, Radix Puerariae 14～18, Semen Cassiae 14～18, Bombyx Batryticatus 4～8, Borneolum Syntheticum 2～6, Styrax 4～8, the Radix Astragali 12～16, Poria 12～16, Fructus Mori dew 16～20, Herba Epimedii 12～16, Colla cornus cervi 25～45, Colla Plastri Testudinis 25～35, Mentholum 2～5 and artificial Moschus 0.1～0.4.

2. the crust cloth cream of the concurrent coronary heart disease of treatment diabetic hypertension according to claim 1 is characterized in that its weight proportion of each component is: Radix Et Caulis Acanthopanacis Senticosi 30, Fructus Lycii 30, Radix Rehmanniae Preparata 20, Rhizoma Dioscoreae 20, Fructus Corni 20, Radix Panacis Quinquefolii 20, Radix Bupleuri 18, Rhizoma Corydalis 18, Radix Salviae Miltiorrhizae 18, Rhizoma Chuanxiong 18, Cortex Moutan 18, Radix Notoginseng 6, Sanguis Draxonis 3, Ramulus Euonymi 18, Pheretima 6, Hirudo 6, Herba Leonuri dew 18, uncommon Herba Siegesbeckiae 18, artificial Calculus Bovis 0.5, Cornu Bubali 6, Concha Meretricis seu Cyclinae 6, Rhizoma Alismatis 16, Fructus Evodiae 6, Radix Puerariae 16, Semen Cassiae 16, Bombyx Batryticatus 6, Borneolum Syntheticum 3, Styrax 6, the Radix Astragali 14, Poria 14, Fructus Mori dew 18, Herba Epimedii 16, Colla cornus cervi 30, Colla Plastri Testudinis 30, Mentholum 3 and artificial Moschus 0.2.

3. prepare the method for the crust cloth cream of the concurrent coronary heart disease of the said treatment diabetic hypertension of claim 1, it is characterized in that may further comprise the steps:

(5) obtain Herba Leonuri dew, Fructus Mori dew, subsequent use;

4. the method for preparing of the crust cloth cream of the concurrent coronary heart disease of treatment diabetic hypertension according to claim 3 is characterized in that Herba Leonuri reveals decoction method: before and after the beginning of autumn, extract the root Herba Leonuri in the flowers are in blossom; Washing and put into jacketed pan, is that 1: 2 ratio adds water in the weight ratio of medicine and water, endures with slow fire and boils back 30 minutes; Medicine is pulled out, medicinal liquid with 100 order sieve impurity screenings after, medicinal liquid reenters in the jacketed pan; Endure with slow fire and to drip into pearl, subsequent use.

5. according to the method for preparing of the crust cloth cream of claim 3 or the concurrent coronary heart disease of 4 described treatment diabetic hypertensions, it is characterized in that Fructus Mori reveals decoction method: before and after the Beginning of summer, win Fructus Mori in the fruit maturation; Washing and put into jacketed pan, is that 1: 2 ratio adds water in the weight ratio of medicine and water, endures with slow fire and boils back 30 minutes; Fructus Mori is pulled out, medicinal liquid with 100 order sieve impurity screenings after, medicinal liquid reenters in the jacketed pan; Endure with slow fire and to drip into pearl, subsequent use.