CN104740583A - Traditional Chinese medicine preparation for relieving Crohn's disease and preparation method for traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for relieving Crohn's disease and preparation method for traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for relieving Crohn's disease. The traditional Chinese medicine preparation is prepared from smoked plum, schisandra chinensis, asarum, dry ginger, coptis chinensis, cortex phellodendri, rhizoma bletillae, pseudo-ginseng powder, monkshood, Chinese angelica, cinnamon, red ginseng, Chinese prickly ash, radix bupleuri, cassia twig, white paeony root, fructus evodiae, myristica fragrans, fructus psoraleae, raw semen coicis, poria cocos, jujube and honey-fried licorice root according to a certain weight proportion. The traditional Chinese medicine preparation has the effects of relieving diarrhea with astringents, healing sores and promoting tissue regeneration, supplementing qi and promoting the production of body fluid and clearing away heat and drying dampness, and can be effectively relieving the symptoms of Crohn's disease, reducing complications, and relieving the pains of a patient, so that a treatment purpose is achieved.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, being specifically related to a kind of Chinese medicine preparation for alleviating Crohn disease.The invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Crohn disease (crohndisease, CD), also known as segmental enteritis, regional enteritis, segmental enteritis and granulomatous enteritis, is a kind of agnogenic bowl inflammatory diseases.Primary disease and chronic non-specific ulcerative colitis are referred to as inflammatory bowel (IBD).The cause of disease of Crohn disease is not yet bright, may be the comprehensive function of multiple paathogenic factor, with dysimmunity, infection and inherited genetic factors like more relevant.Crohn disease is the proliferative lesion running through each layer of intestinal wall, and invades mesentery and regional nodes.Pathological changes is confined to small intestinal (being mainly terminal ileum) and colon person respectively accounts for 30%, and the two involves simultaneously and respectively accounts for 40%, is often ileum and right hemicolon pathological changes.Pathological change is divided into acute inflammation stage, ulcer phase, narrow phase and expectorant pipe Formation period (perforation phase) by Crohn.The pathological changes of primary disease is sections distribution, spaced with normal intestinal segment, distinct, the feature of (skip area) in skip zone.The clinical manifestation of primary disease is more various, with the position of enteral pathological changes, scope, the order of severity, course of disease length and relevant with or without complication.Model case is many in the slow onset of adolescence, and the course of disease is everlasting more than the several months to several years.Active stage and the catabasis different in size, mutually alternately occur, in gradual progress in recurrent exerbation.Minority Acute onset, can have high heat, toxemic symptoms and acute abdomen performance, have severe complication more.Occasionally have and send out symptom outward headed by the intestinal such as paranal peripheral abscess, the formation of expectorant pipe or arthralgia show.
Crohn disease is as a kind of disease of chronic recurrent exerbation, due to its etiology unknown, cause there is no and develop effective medicine, current, drug main for Crohn disease treatment will comprise the biological preparation such as glucocorticoid, Salicylic Acid Formulations, immunosuppressant, antibiotic, although these medicines existing can change the symptom of disease to a certain extent, but can not complete incidence graph disease the state of an illness and reduce the incidence rate of complication, and these hormone medicine long term administrations existing can damage body, have obvious untoward reaction.The traditional Chinese medical science can be made the most of the advantage in this disease for the treatment of, holds on the whole, strengthens patient's resistance, alleviates the generation of complication, and then disease therapy.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation, this Chinese medicine preparation has therapeutic effect obviously for for alleviating Crohn disease, and effective percentage is high, cheap, has no side effect, the feature of taking convenience.
Another object of the present invention is to provide this for alleviating the preparation method of the Chinese medicine preparation of Crohn disease.
Inventor is in clinical treatment practice for many years, observe the misery that Crohn disease brings to patient, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula of the Chinese medicine preparation for alleviating Crohn disease repeatedly, the present invention selects Fructus Mume, Fructus Schisandrae Chinensis, Herba Asari, Rhizoma Zingiberis, Rhizoma Coptidis, Cortex Phellodendri, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng powder, Radix Aconiti Lateralis Preparata, Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Ginseng Rubra, Pericarpium Zanthoxyli, Radix Bupleuri, Ramulus Cinnamomi, the Radix Paeoniae Alba, Fructus Evodiae, Semen Myristicae, Fructus Psoraleae, Semen Coicis, Poria, Fructus Jujubae, Radix Glycyrrhizae Preparata combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is relieving diarrhea with astringents, expelling pus and promoting granulation, supplementing QI for promoting the production of body fluid, effect of heat clearing and damp drying, effectively can alleviate the symptom of Crohn disease, reduce complication, alleviate patient's misery, and then reach the object for the treatment of.
The effect of Chinese medicine of the present invention:
Wherein:
Fructus Mume: be the dry almost ripe fruit of rose department plant plum Prunus mume (Sieh.) Sieb .et Zucc..Nature and flavor: sweet, sour, puckery, warm.Return stomach, large intestine channel.Effect: relieving diarrhea with astringents, astringing to arrest bleeding, expelling pus and promoting granulation.This product is used for not closing up for a long time after carbuncle sore is burst, and external has the effect of removing dampness expelling pus and promoting granulation." Bencao Jingshu ": Fructus Mume, namely the Fructus Mume of the present is also, the sourest." warp " is said: heat impairing vital QI, and evil visitor is in the heart, then gas superinverse and stuffy sensation with restlessness, the heart is uneasy for it.Fructus Mume sour in the mouth, can hold back superficial heat, air-breathing can return unit, therefore the main therapeutic method to keep the adverse QI flowing downwards, heat extraction stuffy sensation with restlessness and feeling at ease also.Dysentery person, large intestine collapse is also; Good saliva xerostomia person, hyperactivity of deficient fire, deficiency of body fluid is also; Acid can hold back asthenic fire, change body fluid, solid intestinal take off, so lead also.Its main limb pain, hemiplegia meciless person, covers because dampness is dipped in meridians, then muscle arteries and veins relaxes vertical, or pain is meciless; Liver governing tendons, sour in taste acting on the liver and nourishing muscle and tendon, liver obtain support, then solid skeleton and pliable tendons, machine-operated tonneau and front card removes.
Fructus Schisandrae Chinensis: be the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or schisandra chinensis Schisandra sphenanthera Rehd. et Wils..Nature and flavor: warm, sour, sweet.Return lung, the heart, kidney channel.Function: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Herba Asari: be aristolochiaceae plant Herba Asari Asarum heterotropoides Fr. Schmidt var.mandshuricum(Maxim.) the dry herb of Kitag., Seoul Herba Asari Asarum sieboldii Miq. var. seoulense Nakai or magnificent Herba Asari Asarum sieboldii Miq..Nature and flavor: pungent; Temperature; Mild toxicity.Return lung meridian, kidney channel, heart channel, Liver Channel, gallbladder meridian, spleen channel.Effect: mass dissipating and swelling eliminating; Induce sweat cold expelling; Wind-expelling pain-stopping; Warming the lung to resolve fluid-retention; The therapeutic method to keep the adverse QI flowing downwards is eliminated the phlegm, sensible.Antibacterial, antivirus action kakuol preserved material, volatilization wet goods have certain In-vitro Inhibitory Effect to gram positive bacteria, bacillus subtilis and Bacillus typhi, and decoct also has inhibitory action to tubercule bacillus and Bacillus typhi.Herba Asari volatile oil is to multiple fungus as Aspergillus flavus, Aspergillus niger, Candida albicans etc. all have inhibitory action, and antibacterial effective ingredient is safrole.α-asaricin has the effect suppressing respiratory syncytial virus propagation.
Rhizoma Zingiberis: be the dry rhizome of zingiber Zingiber officinale Rosc..Nature and flavor: pungent, hot.Return spleen, stomach, the heart, lung meridian.Effect: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.The pyogenic infection of Rhizoma Zingiberis external curing wound.This product hot dry strong, main enter taste warp, be longer than warm middle burnt spleen sun and cold expelling, therefore all middle burnt cold syndrome, the excess-cold syndrome of no matter invading in exogenous cold, or the deficiency-cold syndrome of YANG QI deficiency, be key medicine.
Rhizoma Coptidis: be the dry rhizome of ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C. Y. Cheng et Hsiao or Coptis Teeta Wall Coptis teeta Wall..Nature and flavor: bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.This product heat clearing and damp drying, eliminating fire and detoxication, antibacterial action: staphylococcus aureus, Hemolytic streptococcus, streptococcus pneumoniae, meningococcus, dysentery bacterium, anthrax bacillus etc.Detoxication: antagonism bacteriotoxin, reduction staphylococcus aureus coagulase, hemolysin are tired, and reduce colibacillary virulence.Suppress kinds of experiments inflammation, effective ingredient is berberine, and Anti-inflammatory Mechanism discharges relevant with stimulation corticotropin.
Cortex Phellodendri: be the dry bark of rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri Phellodendron amurense Rupr..Nature and flavor: bitter, cold.Return kidney, bladder, large intestine channel.Effect: heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Modern pharmacology is studied: Cortex Phellodendri water decoction or alcohol preserved material are in vitro to staphylococcus aureus, Staphylococcus albus, Hemolytic streptococcus, Diplococcus pneumoniae, anthrax bacillus, vibrio cholera, diphtheria corynebacterium, bacillus subtilis, escherichia coli, bacillus pyocyaneus, Bacillus typhi, Salmonella paratyphi, meningococcus etc., all there is inhibitory action in various degree. experiment also shows, Cortex Phellodendri is to shigella flexneri, dysentery bacterium has stronger inhibitory action. in addition, Cortex Phellodendri decoct, water logging agent in external to multiple pathogenic dermatophytes, trichomonas vaginitises etc. all have inhibitory action in various degree.This product can heat clearing and damp drying, again can eliminating fire and detoxication, for oral administration, external is all effective, and Cortex Phellodendri has the effect of broad-spectrum antiseptic.
Pseudobulbus Bletillae (Rhizoma Bletillae): be the orchid family herbaceos perennial Pseudobulbus Bletillae (Rhizoma Bletillae) Bletilla striata(Thunb.) dry tuber of Reichb. f..Nature and flavor: pungent, bitter, sweet, puckery, be slightly cold.Return lung, liver, stomach warp.Effect: astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Had record in " book on Chinese herbal medicine is looked for the truth ": Pseudobulbus Bletillae (Rhizoma Bletillae), square book both carried function and had entered lung hemostasis, and carry again can control to fall and flutter folding bone, soup fire is burnt, malignant boil carbuncle, loses the dead flesh of cellulitis, obtained non-like receiving, like puckery, like only more than? do not know book speech function hemostasis person, be because of the puckery meaning of property also; Book speech can be controlled carbuncle and damages the wounded, be because of acrid in the mouth can be loose meaning also.Have loose during this medicine is puckery, invigorating middle warmer has broken, therefore book carries again removing the necrotic tissue, removing blood stasis, tissue regeneration promoting.
Radix Notoginseng powder: be the dry root of panax araliaceae plant Panax notoginseng (Burk.) F. H. Chen.Get Radix Notoginseng, cleaning, drying, fine ground powder.Nature and flavor: sweet, micro-hardship, temperature.Return liver, stomach warp.Effect: dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.Record in " book on Chinese herbal medicine is looked for the truth ": Radix Notoginseng, common people only know that function is stopped blooding bitterly, hardly realize bitterly because blood stasis then aches work, and blood is because only applying loose then blood.The bitter temperature of Radix Notoginseng abnormal smells from the patient, can in its blood stasis of blood systemization.
Radix Aconiti Lateralis Preparata: be the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaeli Debx..Nature and flavor: pungent, sweet are warm greatly; Poisonous.GUIXIN, kidney, spleen channel.Effect: recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, dispersing cold for relieving pain.This product is hot dry strong, walk and do not keep, can be passed through 12 warps, can chase after again lost YANG-depletion, can subsidize again the Yuanyang of deficiency, with tonic with using, the card that all over the body up and down yang-energy is on the decline, yin-cold excess can be controlled, can on help heart-yang to promote blood circulation, middle warming the spleen sun is with strong fortune, lower the kidney warming sun is with benefit fire, and the coldness and pain in the epigastrium caused by deficiency of spleen-YANG and kidneyYANG, cold-damp accumulating in the interior, diarrhea often join Rhizoma Zingiberis.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis has inhibitory action to central nervous system, and volatile oil has the effects such as calmness, hypnosis, analgesia, anesthesia.For blood deficiency and yellow complexion, dizzy cardiopalmus, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores.Carry according to " book on Chinese herbal medicine is just ": " its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, nothing unsuitable." modern medicine study confirmation, Radix Angelicae Sinensis has antibacterial, antiinflammation.
Cortex Cinnamomi: be the bark of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor: hot greatly, pungent, sweet.Return kidney, spleen, the heart, Liver Channel.Effect: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow, promoting blood circulation.The sweet heat of this product, enters spleen kidney channel, is good at YANG invigorating gas and warming the spleen and kidney, dispersing cold for relieving pain.
Radix Ginseng Rubra: be the dry root of cultivation product after steaming of Araliaceae Radix Ginseng Panax ginseng C. A. Mey..Nature and flavor: sweet, micro-hardship, temperature.Return spleen, lung, heart channel.Effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, nourishing qi to stop.
Pericarpium Zanthoxyli: for the dry mature skin (Pericarpium Zanthoxyli) of rutaceae Capsicum annuum L. (fragrant green pepper, Zanthoxylum schinifolium, Pericarpium Zanthoxyli, Canis familiaris L. green pepper) Zanthoxylum schinifolium Sieb. et Zucc. or Pericarpium Zanthoxyli (another name for Sichuan Province green pepper, Fructus Zanthoxyli, Capsicum tetragonum, pericarpium zanthoxyli bungeani, Radix Campylotropis Hirtella (Herba Myrsines Africanae)) Zantho xylum bungeanum Maxim. and seed (Semen zanthoxyli) are used as medicine.Nature and flavor: pungent, temperature.Return spleen, stomach, kidney channel.Effect: warming middle-JIAO to relieve pain, killing parasites for relieving itching.For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis; External treatment eczema pruritus.
Radix Bupleuri: be Umbelliferae herbaceos perennial Radix Bupleuri Bupleurum chinense DC.(Radix Bupleuri) or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium Willd.(Radix Bupleuri Scorzonerifolii) root or herb.Nature and flavor: bitter, pungent, be slightly cold.Return liver, gallbladder meridian.Effect: reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang.Radix Bupleuri has the effect of good dispersing the stagnated live-QI to relieve the stagnation of QI, is the key medicine for the treatment of irritability stasis, to the pain over the hypochondriac region no matter in by stagnation of liver-QI, outer by hindering servant person, all can apply.
Ramulus Cinnamomi: be the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor: acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Ramulus Cinnamomi is warm in nature, and the kind gas that activates yang, can change YIN-cold, hold back resistance yang-energy to YIN-cold, and body fluid can not defeated cloth, the thus disease of retention of water-damp formation phlegm retention.This product energy promoting the flow of QI-blood by warming the meridian, dispersing cold for relieving pain, for all pain cards such as congealing cold with blood stasis.
The Radix Paeoniae Alba: be the dry root of dicotyledon ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: cool, picric acid, is slightly cold.Effect: easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receives antiperspirant.Research shows: the paeoniflorin contained in the Radix Paeoniae Alba has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.This product energy nourishing the liver blood, holding back liver-yin, subduing the hyperfunction of the liver sun, dispersing liver-energy, can delay again that contraction is anxious, relieve the pain pain, is the good medicine of the various pain for the treatment of Liver Channel.
Fructus Evodiae: be rutaceae Fructus Evodiae Evodia rutaecarpa(Juss.) Benth., Shi Hu Evodia rutaecarpa(Juss.) the dry almost ripe fruit of Benth. var. officinalis (Dode) Huang or thin hair Fructus Evodiae Evodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang.Nature and flavor: pungent, bitter, heat; Slightly poisonous.Return liver, spleen, stomach, kidney channel.Effect: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension.This product temperature energy reinforcing spleen and kidney, supporing yang antidiarrheal, for controlling the common medicine of deficiency of spleen-YANG and kidneyYANG, Diarrhoea.
Semen Myristicae: be the dry kernel of Myristicaceae Nutmeg Vegetable meat Fructus Amomi Rotundus Myristica fragrans Houtt..Nature and flavor are pungent, temperature.Return spleen, stomach, large intestine channel.Effect: warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents.For Deficiency and coldness of spleen and stomach, incessant chronic diarrhea, abdominal distention, lack of appetite is vomitted." Amplification on Materia Medica addendum ": Semen Myristicae, warming middle-JIAO spleen reinforcing is ball.Solar corona claims its therapeutic method to keep the adverse QI flowing downwards, must mend and kind transporting with its spleen, gas under also, if non-Pericarpium Citri Reticulatae, Rhizoma Cyperi Zhi Jue let out.
Fructus Psoraleae: be the fruit of legumes psoraleae Psoralea corylifolia L..Nature and flavor: pungent, bitter, temperature.Return kidney, spleen channel.Effect: kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, helping inspiration to relieve asthma.This product energy kidney-replenishing, warm spleen sun, stopping leak rushes down, for controlling the key medicine of deficiency of spleen-YANG and kidneyYANG.This product is worked hard warm-dryness syndrome, can warming and recuperating the gate of life, and replenishing kidney, strengthening waist, tonifying YANG, controlling nocturnal emission with astringent drugs, reducing urination, for controlling the key medicine of insufficiency of kidney-YANG, instability of kidney-QI.
Semen Coicis: be the dry mature kernal of grass Semen Coicis Coix lacryma-jobi L. var. ma-yuen (Roman.) Stapf.Nature and flavor: sweet, light, cool.Return spleen, stomach, lung meridian.Effect: spleen invigorating eliminating dampness by diuresis, eliminating impediment pain relieving, clearing away heat and discharging pus.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.For the disease of retention of damp-heat in the interior, to oliguria with reddish urine, can be equal to Talcum, Medulla Tetrapanacis and use; To hygropyrexia pathogenic factor at edema caused by disorder of QI, the inclined victor of damp.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Sweet the providing additional supplies of this product is oozed, and not only mends but also sharp, and effect is gentle, and property is flat and partially without cold and heat, is the key medicine of promoting diuresis to eliminate damp pathogen.Treatment water wet the edema of expert time, often join Rhizoma Alismatis, Polyporus.Poria decoct has obvious sedation." modality ": " cure mainly Ji Rou Shun muscle of throbbing with fear cautious, dizziness agitation is controlled on side." this product is by heart-spleen boosting and tranquilizing mind.Be used for deficiency of both the heart and spleen, the irritability of insufficiency of vital energy and blood.
Fructus Jujubae: be the dry mature fruit of Rhamnaceae jujube Fructus Jujubae Ziziphus jujuba Mill. var. inermis (Bunge) Rehd..Nature and flavor: sweet, temperature.Return spleen, stomach warp.Effect: really (Fructus Jujubae): invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Bark: antiinflammatory, hemostasis, antidiarrheal.For tracheitis, enteritis, dysentery, metrorrhagia; Traumatic hemorrhage is controlled in external.Root: circulation of qi promoting, invigorates blood circulation, regulating menstruation.For menoxenia, redly to collapse, leucorrhea." herbal classic ": main trusted subordinate's pathogen, regulating the spleen and stomach supports spleen, helps 12 warps.Flat gastric qi, logical nine orifices, mends weak breath, few body fluid, not enough, frightened in body, heaviness of limbs, and hundred medicines." book on Chinese herbal medicine is new again ": invigorating the spleen and replenishing QI, nourishing kidney warming the stomach, controls the deficiency of YIN.
Radix Glycyrrhizae Preparata: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Radix Glycyrrhizae Preparata is that processed goods smoked by the honey of Radix Glycyrrhizae.Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.
Side's solution of the present invention is: Fructus Mume relieving diarrhea with astringents, expelling pus and promoting granulation in side, astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of Fructus Schisandrae Chinensis convergence, Herba Asari mass dissipating and swelling eliminating, Rhizoma Zingiberis warming spleen and stomach for dispelling cold, warming the lung to resolve fluid-retention, Rhizoma Coptidis, Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication, above Six-element is monarch drug altogether, first Rhizoma Coptidis, Cortex Phellodendri heat clearing and damp drying, there is the effect of anti-inflammation, can clear up intestinal pathological changes, Fructus Mume, Fructus Schisandrae Chinensis etc. have the effect of expelling pus and promoting granulation, supplementing QI for promoting the production of body fluid, promote cleaning and the healing of intestinal ulcer surface, prevent the diffusion once again of abscess and granulation, thus reach the object controlling disease.Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation, the hemostasis of Radix Notoginseng powder dissipating blood stasis, subduing swelling and relieving pain, Radix Aconiti Lateralis Preparata recuperating depleted YANG and rescuing the patient from collapse, dispersing cold for relieving pain, Chinese angelica blood supplementing is invigorated blood circulation, Cortex Cinnamomi dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow, the multiple arteries and veins of Radix Ginseng Rubra is admittedly de-, nourishing qi to stop, Pericarpium Zanthoxyli warming middle-JIAO to relieve pain, killing parasites for relieving itching, Radix Bupleuri reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, above a few taste is ministerial drug altogether, has the effect of dissipating blood stasis hemostasis, subduing swelling and relieving pain, alleviate the misery that Crohn disease brings to patient, the dispersing the stagnated live-QI to relieve the stagnation of QI such as Radix Ginseng Rubra, Radix Bupleuri, multiple arteries and veins take off admittedly, strengthen the body constitution of patient, accelerate the recovery of patient.Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the Radix Paeoniae Alba is enriched blood easing the affected liver, suppressing the hyperactive liver pain relieving, Fructus Evodiae dispersing cold for relieving pain, supporing yang antidiarrheal, Semen Myristicae warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents, Fructus Psoraleae warms up spleen sun, stopping leak rushes down, Semen Coicis spleen invigorating eliminating dampness by diuresis, eliminating impediment pain relieving, Poria promoting diuresis to eliminate damp pathogen, Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, a few taste is adjuvant drug altogether above, the health of conditioning patient, strengthens curative effect of medication, promotes that patient recovers.Radix Glycyrrhizae Preparata priming is returned through, coordinating the actions of various ingredients in a prescription, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has effect of relieving diarrhea with astringents, expelling pus and promoting granulation, supplementing QI for promoting the production of body fluid, heat clearing and damp drying, can effectively alleviate and treat Crohn disease.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Fructus Mume 15-25 part, Fructus Schisandrae Chinensis 7-17 part, Herba Asari 1-5 part, Rhizoma Zingiberis 10-20 part, Rhizoma Coptidis 3-9 part, Cortex Phellodendri 7-17 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 4-14 part, Radix Notoginseng powder 1-5 part, Radix Aconiti Lateralis Preparata 7-17 part, Radix Angelicae Sinensis 10-20 part, Cortex Cinnamomi 3-9 part, Radix Ginseng Rubra 5-15 part, Pericarpium Zanthoxyli 3-9 part, Radix Bupleuri 7-17 part, Ramulus Cinnamomi 7-17 part, Radix Paeoniae Alba 10-20 part, Fructus Evodiae 3-9 part, Semen Myristicae 4-14 part, Fructus Psoraleae 10-20 part, Semen Coicis 15-25 part, Poria 10-20 part, Fructus Jujubae 7-17 part, Radix Glycyrrhizae Preparata 3-9 part.
Wherein be preferably: Fructus Mume 20 parts, Fructus Schisandrae Chinensis 12 parts, Herba Asari 3 parts, Rhizoma Zingiberis 15 parts, Rhizoma Coptidis 6 parts, Cortex Phellodendri 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 9 parts, Radix Notoginseng powder 3 parts, Radix Aconiti Lateralis Preparata 12 parts, Radix Angelicae Sinensis 15 parts, Cortex Cinnamomi 6 parts, Radix Ginseng Rubra 10 parts, 6 parts, Pericarpium Zanthoxyli, Radix Bupleuri 12 parts, Ramulus Cinnamomi 12 parts, the Radix Paeoniae Alba 15 parts, Fructus Evodiae 6 parts, Semen Myristicae 9 parts, Fructus Psoraleae 15 parts, Semen Coicis 20 parts, 15 parts, Poria, 12 parts, Fructus Jujubae, Radix Glycyrrhizae Preparata 6 parts.
Medicine of the present invention can adopt the conventional fabrication process of Chinese medicine preparation, can be made into said dosage form on any one pharmaceutics, as pill, powder, tablet, capsule, granule, syrup, oral liquid etc.Such as these crude drug grind into fine powder mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.
The preferred preparation method of the present invention is decoction, and its preparation method is as follows:
Step one: by weight proportion of the present invention, takes Fructus Mume, Fructus Schisandrae Chinensis, Pericarpium Zanthoxyli, Fructus Evodiae, Semen Myristicae, Fructus Psoraleae, Semen Coicis, Fructus Jujubae bundle becomes medicated bag, be put in cold water and soak 15-25 minute, for subsequent use;
Step 2: by weight proportion of the present invention, take Radix Aconiti Lateralis Preparata and put into marmite, add in step one and remain cold water 1-2 centimetre, decoct 20 minutes with high heat, then Rhizoma Zingiberis is taken, Rhizoma Coptidis, Cortex Phellodendri, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Ginseng Rubra, the Radix Paeoniae Alba puts into marmite, add step one and soak rear remaining cold water, smeared medical material 3-5 centimetre, first boil with high heat, again with 30-40 minute at a simmer, filter, obtain filtrate, the water of 2-3 centimetre is added in residue medicinal residues, then Herba Asari is added, Radix Bupleuri, Poria, and a kind of medicated bag of step continues decoction 20 minutes, finally add Ramulus Cinnamomi, Radix Glycyrrhizae Preparata decocts 15 minutes, filter, obtain filtrate, merge twice filtrate, waste, for subsequent use,
Step 3: by weight proportion of the present invention, the hot soup taken in Radix Notoginseng powder step 2 is taken after mixing it with water, both of the present invention, alleviate the Chinese medicine decoction of Crohn disease.
Medicine of the present invention has the effects such as relieving diarrhea with astringents, expelling pus and promoting granulation, supplementing QI for promoting the production of body fluid, heat clearing and damp drying, and successful, effective percentage is high, cheap, have no side effect, taking convenience, effectively can alleviate the misery that Crohn disease brings to patient, reduce the generation of complication, conditioning patient body, and then reach the object for the treatment of.
Detailed description of the invention
Embodiment one, Fructus Mume 15 parts, Fructus Schisandrae Chinensis 7 parts, Herba Asari 1 part, Rhizoma Zingiberis 10 parts, Rhizoma Coptidis 3 parts, Cortex Phellodendri 7 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 4 parts, Radix Notoginseng powder 1 part, Radix Aconiti Lateralis Preparata 7 parts, Radix Angelicae Sinensis 10 parts, Cortex Cinnamomi 3 parts, Radix Ginseng Rubra 5 parts, 3 parts, Pericarpium Zanthoxyli, Radix Bupleuri 7 parts, Ramulus Cinnamomi 7 parts, the Radix Paeoniae Alba 10 parts, Fructus Evodiae 3 parts, Semen Myristicae 4 parts, Fructus Psoraleae 10 parts, Semen Coicis 15 parts, 10 parts, Poria, 7 parts, Fructus Jujubae, Radix Glycyrrhizae Preparata 3 parts.
Embodiment two, Fructus Mume 20 parts, Fructus Schisandrae Chinensis 12 parts, Herba Asari 3 parts, Rhizoma Zingiberis 15 parts, Rhizoma Coptidis 6 parts, Cortex Phellodendri 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 9 parts, Radix Notoginseng powder 3 parts, Radix Aconiti Lateralis Preparata 12 parts, Radix Angelicae Sinensis 15 parts, Cortex Cinnamomi 6 parts, Radix Ginseng Rubra 10 parts, 6 parts, Pericarpium Zanthoxyli, Radix Bupleuri 12 parts, Ramulus Cinnamomi 12 parts, the Radix Paeoniae Alba 15 parts, Fructus Evodiae 6 parts, Semen Myristicae 9 parts, Fructus Psoraleae 15 parts, Semen Coicis 20 parts, 15 parts, Poria, 12 parts, Fructus Jujubae, Radix Glycyrrhizae Preparata 6 parts.
Embodiment three, Fructus Mume 25 parts, Fructus Schisandrae Chinensis 17 parts, Herba Asari 5 parts, Rhizoma Zingiberis 20 parts, Rhizoma Coptidis 9 parts, Cortex Phellodendri 17 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 14 parts, Radix Notoginseng powder 5 parts, Radix Aconiti Lateralis Preparata 17 parts, Radix Angelicae Sinensis 20 parts, Cortex Cinnamomi 9 parts, Radix Ginseng Rubra 15 parts, 9 parts, Pericarpium Zanthoxyli, Radix Bupleuri 17 parts, Ramulus Cinnamomi 17 parts, the Radix Paeoniae Alba 20 parts, Fructus Evodiae 9 parts, Semen Myristicae 14 parts, Fructus Psoraleae 20 parts, Semen Coicis 25 parts, 20 parts, Poria, 17 parts, Fructus Jujubae, Radix Glycyrrhizae Preparata 9 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
Accept patient 60 example for medical treatment, wherein male 31 example, women 29 example, M-F is about 1.07:1, max age 68 years old, minimal ages 30 years old, and the course of disease time, not etc. every basic documents such as Gender, age, the course of disease were substantially not identical.
Two, Therapeutic Method
According to the embodiment of the present invention two, weighting raw materials (daily dose), decocting, filter and remove residue, takes at twice, within 10th, is a course for the treatment of.
Model case and curative effect:
Case one, Zheng, female, 55 years old, repeatedly there is diarrhoea in patient, stomachache, and have the phenomenon lost weight, hospital is often gone to take an antibiotic medicine when patient suffers from abdominal pain, analgesic, although symptom can be alleviated, but soon will recur, patient suffers from abdominal pain in the recent period and increases the weight of, examination in hospital is removed in decision, electronic colonoscope and Mucosa Biopsy are diagnosed as Crohn disease, patient adopts made preparation in the embodiment of the present invention two, and the preparation method preferably selected, after taking two courses for the treatment of, patient suffers from abdominal pain, diarrhoea phenomenon disappears substantially, body weight returns increasing to some extent, body constitution obviously takes a turn for the better, patient holds on again and takes a wheat harvesting period, patient's readme physical condition is good, remove examination in hospital, intestinal mucosal lesion recovers substantially, livelihood restoration is normal, follow up a case by regular visits to, do not recur.
Case two, Guo, man, 69 years old, patient's abdominal distention, diarrhoea, and with discontinuity umbilicus week stomachache, defecation is not smooth, row is had to feel not to the utmost, patient in the recent period and have the fever of unknown cause, after oral antibiotic is brought down a fever, will not recur in a few days, patient goes to hospital to check, finally be diagnosed as Crohn disease, patient adopts made preparation in the embodiment of the present invention two, and the preparation method preferably selected, after taking two courses for the treatment of, stomachache, diarrhoea phenomenon is significantly taken a turn for the better, fever phenomenon had been there is not in patient since taking medicine, appetite obviously increases, body constitution is also strengthened, patient adheres to again having taken about one month, hospital is gone to check, intestinal mucosa recovers normal substantially, the state of an illness is controlled, live unaffected, follow up a case by regular visits to, do not recur.
Claims (4)
1. one kind for alleviating the Chinese medicine preparation of Crohn disease, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Fructus Mume 15-25 part, Fructus Schisandrae Chinensis 7-17 part, Herba Asari 1-5 part, Rhizoma Zingiberis 10-20 part, Rhizoma Coptidis 3-9 part, Cortex Phellodendri 7-17 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 4-14 part, Radix Notoginseng powder 1-5 part, Radix Aconiti Lateralis Preparata 7-17 part, Radix Angelicae Sinensis 10-20 part, Cortex Cinnamomi 3-9 part, Radix Ginseng Rubra 5-15 part, Pericarpium Zanthoxyli 3-9 part, Radix Bupleuri 7-17 part, Ramulus Cinnamomi 7-17 part, Radix Paeoniae Alba 10-20 part, Fructus Evodiae 3-9 part, Semen Myristicae 4-14 part, Fructus Psoraleae 10-20 part, Semen Coicis 15-25 part, Poria 10-20 part, Fructus Jujubae 7-17 part, Radix Glycyrrhizae Preparata 3-9 part.
2. the Chinese medicine preparation for alleviating Crohn disease according to claims 1, it is characterized in that, be made up of the medicine of following weight portion: Fructus Mume 20 parts, Fructus Schisandrae Chinensis 12 parts, Herba Asari 3 parts, Rhizoma Zingiberis 15 parts, Rhizoma Coptidis 6 parts, Cortex Phellodendri 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 9 parts, Radix Notoginseng powder 3 parts, Radix Aconiti Lateralis Preparata 12 parts, Radix Angelicae Sinensis 15 parts, Cortex Cinnamomi 6 parts, Radix Ginseng Rubra 10 parts, 6 parts, Pericarpium Zanthoxyli, Radix Bupleuri 12 parts, Ramulus Cinnamomi 12 parts, the Radix Paeoniae Alba 15 parts, Fructus Evodiae 6 parts, Semen Myristicae 9 parts, Fructus Psoraleae 15 parts, Semen Coicis 20 parts, 15 parts, Poria, 12 parts, Fructus Jujubae, Radix Glycyrrhizae Preparata 6 parts.
3. the Chinese medicine preparation for alleviating Crohn disease according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.
4. one kind for alleviating the preparation method of the Chinese medicine preparation of Crohn disease, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, take Fructus Mume, Fructus Schisandrae Chinensis, Pericarpium Zanthoxyli, Fructus Evodiae, Semen Myristicae, Fructus Psoraleae, Semen Coicis, Fructus Jujubae bundle become medicated bag, be put in cold water and soak 15-25 minute, for subsequent use, step 2: by weight proportion of the present invention, take Radix Aconiti Lateralis Preparata and put into marmite, add in step one and remain cold water 1-2 centimetre, decoct 20 minutes with high heat, then Rhizoma Zingiberis is taken, Rhizoma Coptidis, Cortex Phellodendri, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Ginseng Rubra, the Radix Paeoniae Alba puts into marmite, add step one and soak rear remaining cold water, smeared medical material 3-5 centimetre, first boil with high heat, again with 30-40 minute at a simmer, filter, obtain filtrate, the water of 2-3 centimetre is added in residue medicinal residues, then Herba Asari is added, Radix Bupleuri, Poria, and a kind of medicated bag of step continues decoction 20 minutes, finally add Ramulus Cinnamomi, Radix Glycyrrhizae Preparata decocts 15 minutes, filter, obtain filtrate, merge twice filtrate, waste, for subsequent use, step 3: by weight proportion of the present invention, the hot soup taken in Radix Notoginseng powder step 2 is taken after mixing it with water, both of the present invention, alleviate the Chinese medicine decoction of Crohn disease.
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| CN114288380A (en) * | 2022-01-12 | 2022-04-08 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Traditional Chinese medicine composition for treating Crohn's disease and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105106900A (en) * | 2015-09-22 | 2015-12-02 | 姜水清 | Chinese herbal preparation for treating small intestinal Crohn's disease |
| CN106138889A (en) * | 2016-08-18 | 2016-11-23 | 迟玉善 | A kind of treat cancer, furuncle and the Chinese medicine preparation of unknown tumor and preparation method |
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| CN114288380A (en) * | 2022-01-12 | 2022-04-08 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Traditional Chinese medicine composition for treating Crohn's disease and application thereof |
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