CN104740557A - Traditional Chinese medicine composition and cream for treating rheumatism and preparation method of traditional Chinese medicine composition and cream - Google Patents
Traditional Chinese medicine composition and cream for treating rheumatism and preparation method of traditional Chinese medicine composition and cream Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition and a cream for treating rheumatism and a preparation method of the traditional Chinese medicine composition and the cream. The traditional Chinese medicine composition and the cream are capable of effectively solving the problems of poor effects, and high toxic or side effects of medicines for treating rheumatism. The technical scheme is as follows: the traditional Chinese medicine composition comprises the following raw materials by weight: 13-17g of angelica sinensis, 9-11g of ligusticum wallichii, 9-11g of pseudo-ginseng, 13-17g of safflower carthamus, 9-11g of teasel root, 9-11g of radix angelicae pubescentis, 9-11g of notopterygium root, 13-17g of lycopodium clavatum, 11-17g of radix puerariae, 13-17g of divaricate saposhnikovia root, 9-11g of medicinal cyathula root, 9-11g of myrrh, 4-6g of radix aconiti preparata, 11-17g of cinnamon, 9-11g of dried ginger, 3-6g of asarum and 11-19g of fructus evodiae. The traditional Chinese medicine cream of the traditional Chinese medicine composition disclosed by the invention is made of pure natural raw material traditional Chinese medicines, the various medicines are organically matched, are mutually supported and are reasonable in compatibility; the raw materials are abundant; the method is simple; the traditional Chinese medicine cream has good anti-inflammatory, analgesic and immunosuppressive actions, a good curative effect and a low cost, as well as is a great innovation in medicines for treating rheumatism.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly one treats rheumatismal Chinese medicine composition, ointment and preparation method thereof.
Background technology
Rheumatism is one group, and to invade joint, skeleton, muscle, blood vessel and relevant soft tissue or connective tissue be the disease led, and wherein majority is autoimmune disease.Morbidity is much more hidden and slow, and the course of disease is longer, and mostly has genetic predisposition.Motherland's medical science is referred to as arthromyodynia, Huangdi's Internal Classics: " the wet three gas heterozygosis of wind and cold are numbness ".Comprise rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, psoriasis, rheumatic fever, palindromic rheumatism, lupus erythematosus, arteritis, polymyositis, tenosynovitis, fibromyalgia, arthritis with inflammatory bowel disease, rheumatic heart disease etc.Current rheumatism is a world medicine difficult problem, there is no breakthrough for rheumatismal research, simultaneously also without the medicine of this type of disease of radical cure.Western medical treatment primary disease is mainly NSAID (non-steroidal anti-inflammatory drug), immunosuppressant and hormone, and the side effect of its long-term prescription can not be ignored.And Chinese medicine day by day demonstrates the advantage of its uniqueness in rheumatismal treatment, contain potentiality greatly.
Summary of the invention
For above-mentioned situation, for solving the defect of prior art, the object of the present invention is just to provide one and treats rheumatismal Chinese medicine composition, ointment and preparation method thereof, effectively can solve the rheumatismal effect of drugs for the treatment of not good, the problem that toxic and side effects is large.
The technical scheme that the present invention solves is, one treats rheumatismal Chinese medicine composition, comprises the raw material of following weighing scale: Radix Angelicae Sinensis 13-17g, Rhizoma Chuanxiong 9-11g, Radix Notoginseng 9-11g, Flos Carthami 13-17g, Radix Dipsaci 9-11g, Radix Angelicae Pubescentis 9-11g, Rhizoma Et Radix Notopterygii 9-11g, Herba Lycopodii 13-17g, Radix Puerariae 11-17g, Radix Saposhnikoviae 13-17g, Radix Cyathulae 9-11g, Myrrha 9-11g, Radix Aconiti Preparata 4-6g, Cortex Cinnamomi 11-17g, Rhizoma Zingiberis 9-11g, Herba Asari 3-6g, Fructus Evodiae 11-19g.
The present composition adopts the raw material Chinese medicine of pure natural to make, and between various medicine, organic cooperation, supports mutually, and compatibility is reasonable, abundant raw material, good effect, and cost is low, is that on treatment treatment rheumatism medicine innovates greatly.
One treats rheumatismal Chinese medicine composition ointment, comprise the raw material of following weighing scale: Radix Angelicae Sinensis 13-17g, Rhizoma Chuanxiong 9-11g, Radix Notoginseng 9-11g, Flos Carthami 13-17g, Radix Dipsaci 9-11g, Radix Angelicae Pubescentis 9-11g, Rhizoma Et Radix Notopterygii 9-11g, Herba Lycopodii 13-17g, Radix Puerariae 11-17g, Radix Saposhnikoviae 13-17g, Radix Cyathulae 9-11g, Myrrha 9-11g, Radix Aconiti Preparata 4-6g, Cortex Cinnamomi 11-17g, Rhizoma Zingiberis 9-11g, Herba Asari 3-6g, Fructus Evodiae 11-19g, stearic acid 60g, glyceryl monostearate 20g, glycerol 50g, Oleum Ricini 100g, ethyl hydroxybenzoate 0.5g, triethanolamine 8g and distilled water 250mL.
Treat a preparation method for rheumatismal Chinese medicine composition ointment, comprise the following steps:
Comprise the following steps:
(1) Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Flos Carthami, Radix Dipsaci, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Herba Lycopodii, Radix Puerariae, Radix Saposhnikoviae, Radix Cyathulae, Myrrha, Radix Aconiti Preparata, Cortex Cinnamomi, Rhizoma Zingiberis, Herba Asari, Fructus Evodiae were pulverized 100 mesh sieves, mixing, obtains fine medicinal material powder, for subsequent use;
(2) stearic acid, tristerin and ethyl hydroxybenzoate are added in Oleum Ricini, be heated to 70 DEG C ~ 80 DEG C, stearic acid, glyceryl monostearate and ethyl hydroxybenzoate are dissolved in Oleum Ricini completely, obtain oily solution;
By glycerol and distilled water mixing, be heated to 50 DEG C ~ 60 DEG C, then add triethanolamine, stir, make glycerol, distilled water and triethanolamine mix homogeneously, obtain aqueous solution;
By oily solution and aqueous solution mix homogeneously, until be cooled to room temperature, obtain O/W type emulsifiable paste matrix;
(3) the fine medicinal material powder 20g taking step (1) adds in O/W type emulsifiable paste matrix 500g, stirs, to obtain final product.
Chinese medicine composition dairy cow of the present invention adopts the raw material Chinese medicine of pure natural to make, organic cooperation between various medicine, mutual support, compatibility is reasonable, abundant raw material, method is simple, select the approach of local application, select nontoxic, tasteless, Glycerin, the unguentum being easy to Transdermal absorption is substrate, administration can be put on the skin outside patient local, directly act on affected part, medicine passes through transhipment absorbed into serum by horny layer transhipment and epidermis deep layer blood capillary, simultaneously dairy cow can be partially formed a kind of perspiration and be difficult to the relative air-tight state of evaporation and diffusion, water content of stratum corneum is improved, horny layer expand into porous state, be beneficial to drug osmotic, in Chinese medicine, fragrant ingredient can sting olive local vascular dilation, blood flow accelerates, be beneficial to drug osmotic to absorb, local joint vasodilation can be made, blood flow accelerates, histiocyte membrane permeability increases, improve local organization Nutrition and Metabolism, promote tissue regeneration, produce analgesia, antiinflammation, and have no side effect, patient's no pain, be easy to accept, can life-time service, and there is good antiinflammatory, analgesia and immunosuppressive action, good effect, cost is low, that one on treatment rheumatism medicine is innovated greatly.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.
Embodiment 1
The rheumatismal Chinese medicine composition for the treatment of of the present embodiment, comprises the raw material of following weighing scale: Radix Angelicae Sinensis 13g, Rhizoma Chuanxiong 9g, Radix Notoginseng 9g, Flos Carthami 13g, Radix Dipsaci 9g, Radix Angelicae Pubescentis 9g, Rhizoma Et Radix Notopterygii 9g, Herba Lycopodii 13g, Radix Puerariae 11g, Radix Saposhnikoviae 13g, Radix Cyathulae 9g, Myrrha 9g, Radix Aconiti Preparata 4g, Cortex Cinnamomi 11g, Rhizoma Zingiberis 9g, Herba Asari 3g, Fructus Evodiae 11g.
The rheumatismal Chinese medicine composition ointment for the treatment of of the present embodiment, comprises the raw material of following weighing scale: Radix Angelicae Sinensis 13g, Rhizoma Chuanxiong 9g, Radix Notoginseng 9g, Flos Carthami 13g, Radix Dipsaci 9g, Radix Angelicae Pubescentis 9g, Rhizoma Et Radix Notopterygii 9g, Herba Lycopodii 13g, Radix Puerariae 11g, Radix Saposhnikoviae 13g, Radix Cyathulae 9g, Myrrha 9g, Radix Aconiti Preparata 4g, Cortex Cinnamomi 11g, Rhizoma Zingiberis 9g, Herba Asari 3g, Fructus Evodiae 11g, stearic acid 60g, glyceryl monostearate 20g, glycerol 50g, Oleum Ricini 100g, ethyl hydroxybenzoate 0.5g, triethanolamine 8g and distilled water 250mL.
The preparation method of the rheumatismal Chinese medicine composition ointment for the treatment of of the present embodiment, comprises the following steps:
(1) Radix Angelicae Sinensis 13g, Rhizoma Chuanxiong 9g, Radix Notoginseng 9g, Flos Carthami 13g, Radix Dipsaci 9g, Radix Angelicae Pubescentis 9g, Rhizoma Et Radix Notopterygii 9g, Herba Lycopodii 13g, Radix Puerariae 11g, Radix Saposhnikoviae 13g, Radix Cyathulae 9g, Myrrha 9g, Radix Aconiti Preparata 4g, Cortex Cinnamomi 11g, Rhizoma Zingiberis 9g, Herba Asari 3g, Fructus Evodiae 11g were pulverized 100 mesh sieves, mixing, obtain fine medicinal material powder, for subsequent use;
(2) stearic acid 60g, glyceryl monostearate 20g and ethyl hydroxybenzoate 0.5g are added in Oleum Ricini 100g, be heated to 70 DEG C, stearic acid, glyceryl monostearate and ethyl hydroxybenzoate are dissolved in Oleum Ricini completely, obtain oily solution;
Glycerol 50g and distilled water 250mL is mixed, is heated to 50 DEG C, then add triethanolamine 8g, stir, make glycerol, distilled water and triethanolamine mix homogeneously, obtain aqueous solution;
By oily solution and aqueous solution mix homogeneously, until be cooled to room temperature, obtain O/W type emulsifiable paste matrix;
(3) the fine medicinal material powder 20g taking step (1) adds in O/W type emulsifiable paste matrix 500g, stirs, to obtain final product.
Embodiment 2
The rheumatismal Chinese medicine composition for the treatment of of the present embodiment, comprises the raw material of following weighing scale: Radix Angelicae Sinensis 13-17g, Rhizoma Chuanxiong 10g, Radix Notoginseng 10g, Flos Carthami 15g, Radix Dipsaci 10g, Radix Angelicae Pubescentis 10g, Rhizoma Et Radix Notopterygii 10g, Herba Lycopodii 15g, Radix Puerariae 14g, Radix Saposhnikoviae 15g, Radix Cyathulae 10g, Myrrha 10g, Radix Aconiti Preparata 5g, Cortex Cinnamomi 14g, Rhizoma Zingiberis 10g, Herba Asari 5g, Fructus Evodiae 15g.
The rheumatismal Chinese medicine composition ointment for the treatment of of the present embodiment, comprises the raw material of following weighing scale: Radix Angelicae Sinensis 13-17g, Rhizoma Chuanxiong 10g, Radix Notoginseng 10g, Flos Carthami 15g, Radix Dipsaci 10g, Radix Angelicae Pubescentis 10g, Rhizoma Et Radix Notopterygii 10g, Herba Lycopodii 15g, Radix Puerariae 14g, Radix Saposhnikoviae 15g, Radix Cyathulae 10g, Myrrha 10g, Radix Aconiti Preparata 5g, Cortex Cinnamomi 14g, Rhizoma Zingiberis 10g, Herba Asari 5g, Fructus Evodiae 15g, stearic acid 60g, glyceryl monostearate 20g, glycerol 50g, Oleum Ricini 100g, ethyl hydroxybenzoate 0.5g, triethanolamine 8g and distilled water 250mL.
The preparation method of the rheumatismal Chinese medicine composition ointment for the treatment of of the present embodiment, comprises the following steps:
(1) Radix Angelicae Sinensis 13-17g, Rhizoma Chuanxiong 10g, Radix Notoginseng 10g, Flos Carthami 15g, Radix Dipsaci 10g, Radix Angelicae Pubescentis 10g, Rhizoma Et Radix Notopterygii 10g, Herba Lycopodii 15g, Radix Puerariae 14g, Radix Saposhnikoviae 15g, Radix Cyathulae 10g, Myrrha 10g, Radix Aconiti Preparata 5g, Cortex Cinnamomi 14g, Rhizoma Zingiberis 10g, Herba Asari 5g, Fructus Evodiae 15g were pulverized 100 mesh sieves, mixing, obtain fine medicinal material powder, for subsequent use;
(2) stearic acid 60g, glyceryl monostearate 20g and ethyl hydroxybenzoate 0.5g are added in Oleum Ricini 100g, be heated to 75 DEG C, stearic acid, glyceryl monostearate and ethyl hydroxybenzoate are dissolved in Oleum Ricini completely, obtain oily solution;
Glycerol 50g and distilled water 250mL is mixed, is heated to 55 DEG C, then add triethanolamine 8g, stir, make glycerol, distilled water and triethanolamine mix homogeneously, obtain aqueous solution;
By oily solution and aqueous solution mix homogeneously, until be cooled to room temperature, obtain O/W type emulsifiable paste matrix;
(3) the fine medicinal material powder 20g taking step (1) adds in O/W type emulsifiable paste matrix 500g, stirs, to obtain final product.
Embodiment 3
The rheumatismal Chinese medicine composition for the treatment of of the present embodiment, comprises the raw material of following weighing scale: Radix Angelicae Sinensis 17g, Rhizoma Chuanxiong 11g, Radix Notoginseng 11g, Flos Carthami 17g, Radix Dipsaci 11g, Radix Angelicae Pubescentis 11g, Rhizoma Et Radix Notopterygii 11g, Herba Lycopodii 17g, Radix Puerariae 17g, Radix Saposhnikoviae 17g, Radix Cyathulae 11g, Myrrha 11g, Radix Aconiti Preparata 6g, Cortex Cinnamomi 17g, Rhizoma Zingiberis 11g, Herba Asari 6g, Fructus Evodiae 19g.
The rheumatismal Chinese medicine composition ointment for the treatment of of the present embodiment, comprises the raw material of following weighing scale: Radix Angelicae Sinensis 17g, Rhizoma Chuanxiong 11g, Radix Notoginseng 11g, Flos Carthami 17g, Radix Dipsaci 11g, Radix Angelicae Pubescentis 11g, Rhizoma Et Radix Notopterygii 11g, Herba Lycopodii 17g, Radix Puerariae 17g, Radix Saposhnikoviae 17g, Radix Cyathulae 11g, Myrrha 11g, Radix Aconiti Preparata 6g, Cortex Cinnamomi 17g, Rhizoma Zingiberis 11g, Herba Asari 6g, Fructus Evodiae 19g, stearic acid 60g, glyceryl monostearate 20g, glycerol 50g, Oleum Ricini 100g, ethyl hydroxybenzoate 0.5g, triethanolamine 8g and distilled water 250mL.
The preparation method of the rheumatismal Chinese medicine composition ointment for the treatment of of the present embodiment, comprises the following steps:
(1) Radix Angelicae Sinensis 17g, Rhizoma Chuanxiong 11g, Radix Notoginseng 11g, Flos Carthami 17g, Radix Dipsaci 11g, Radix Angelicae Pubescentis 11g, Rhizoma Et Radix Notopterygii 11g, Herba Lycopodii 17g, Radix Puerariae 17g, Radix Saposhnikoviae 17g, Radix Cyathulae 11g, Myrrha 11g, Radix Aconiti Preparata 6g, Cortex Cinnamomi 17g, Rhizoma Zingiberis 11g, Herba Asari 6g, Fructus Evodiae 19g were pulverized 100 mesh sieves, mixing, obtain fine medicinal material powder, for subsequent use;
(2) stearic acid 60g, glyceryl monostearate 20g and ethyl hydroxybenzoate 0.5g are added in Oleum Ricini 100g, be heated to 80 DEG C, stearic acid, glyceryl monostearate and ethyl hydroxybenzoate are dissolved in Oleum Ricini completely, obtain oily solution;
Glycerol 50g and distilled water 250mL is mixed, is heated to 60 DEG C, then add triethanolamine 8g, stir, make glycerol, distilled water and triethanolamine mix homogeneously, obtain aqueous solution;
By oily solution and aqueous solution mix homogeneously, until be cooled to room temperature, obtain O/W type emulsifiable paste matrix;
(3) the fine medicinal material powder 20g taking step (1) adds in O/W type emulsifiable paste matrix 500g, stirs, to obtain final product.
The present invention it is to be noted, the technological core of request protection of the present invention is prescription (Chinese medicine compound), every decoction made according to this Chinese medicine compound, pill, and powder or capsule, all belong to the scope of request of the present invention protection.
In said medicine, wherein:
Radix Angelicae Sinensis, call dryly to return, horse hair Radix Angelicae Sinensis, the Qin which, horse hair is returned, cloud is returned, Radix Angelicae Gigatis herbaceos perennial, at distribution in China in Gansu, Yunnan, Sichuan, Qinghai, Shaanxi, Hunan, Hubei, the ground such as Guizhou, all there is cultivation various places.The root of Radix Angelicae Sinensis can be used as medicine, and is one of the most frequently used Chinese medicine.Cure mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Rhizoma Chuanxiong, is perennial herb, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, and the pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving, and pungent temperature rise is fallen apart, and all hyperactivity of YANG due to deficiency of YIN and excessive rising of liver-YANG person should not apply; Menorrhagia, anemia of pregnant woman also avoid use.
Radix Notoginseng, has another name called Radix Notoginseng, Radix Notoginseng, Herba Senecionis Chrysanthemoidis, blood mountain grass, ancient times also known as clear ginseng, Herba Wedeliae Wallichii, Panax pseudoginseng, Typhonium flagelliforme (Lodd.) Blume etc., has dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.Cure mainly spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast ventral spine pain, tumbling down swells and ache.
Flos Carthami, another name: red indigo plant flower thorn Flos Carthami, swells and ache for amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, traumatic injury, skin infection.Have blood circulation promoting and blood stasis dispelling, wet dissipation goes the effect swollen.
Radix Dipsaci, has another name called shaven head, is the root of Dipsacaceae herbaceos perennial Radix Dipsaci, gains the name because of energy " synthetism of continuous folding ".Autumn excavates, and removing root head and fibrous root, be dried to half-dried with low baking temperature, when bank up " diaphoresis " is to inner virescence, then dries." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians determine in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) is ached, and antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine.”
Radix Angelicae Pubescentis is the dry root of samphire Angelica pubescens.Main product in Sichuan, Hubei, the ground such as Anhui.At the beginning of spring or autumn end excavate, removing fibrous root and silt, a heatable brick bed, to half-dried, is banked up 2 ~ 3 days, after feeling like jelly again a heatable brick bed to absolutely dry.Section, raw use." book on Chinese herbal medicine just ": " specially reason part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels rheumatism, two pain in foot numbness, pruritus due to damp pathogen contracture." modern study, Radix Angelicae Pubescentis has antiinflammatory, analgesia and sedation; Inhibitory action is had to platelet aggregation; And it is not have hypotensive effect, but lasting; Contained bergapten, xanthotoxin etc. have photosensitive and antitumor action.
Rhizoma Et Radix Notopterygii, another name Qiang is blue or green, protect Qiang envoy, recklessly king envoy, Qiang is sliding, move back wind envoy, black powder, cures mainly: warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, speckle is bald; Affection of exogenous wind-cold, have a headache lossless, mimeograph cold-damp numbness, edema due to wind pathogen edema, sore swollen toxin.
Herba Lycopodii, pungent loose, bitter dry, Wen Tong, energy Eradicates rheumatism, enters the especially kind the meridian dredging of liver.Control anemofrigid-damp arthralgia, joint aches, joint stuffiness, reducing swelling and alleviating pain, control traumatic injury, pain caused by ecchymoma.
Radix Puerariae is the tuber of liana Herba Gelsemii Elegantis, stem is by sparse brown long bristle, and be that the one of some provinces and regions of southern china often eats vegetable, its sweet in the mouth is cool good to eat, is often used as Baoshang.Its main component is starch, in addition containing have an appointment 12% flavone compound, comprise daidzin, daidzein, puerarin etc. more than 10 and plant; And containing daucosterol, aminoacid, Coumarins etc.Radix Puerariae hyoscine, Radix Puerariae extraction flavonoid substances is combined with Folium Mori extract deoxynojirimycin and forms a kind of novel substance---and wash clear sugar element (cics) of pancreas, there is the effects such as blood sugar lowering, blood fat, antiinflammatory.Radix Puerariae have induce sweat bring down a fever, the function of promoting the production of body fluid to quench thirst, antidiarrheal, and the symptom such as stiffness of the nape, dizziness, headache of hypertensive diabetes patient can be improved.
Radix Saposhnikoviae, another name copper rues, Hui Yun, return grass, herbaceos perennial, effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly: affection of exogenous wind-cold; Headache general pain; Rheumatic arthralgia; Joint is ached; Stomachache is had loose bowels; Discharging fresh blood stool; Tetanus; Rubella pruritus; Skin infection from the beginning of.
Radix Cyathulae, another name Radix Achyranthis Bidentatae, turning knee joint, the full Radix Achyranthis Bidentatae in sky, is the dry root of amaranthaceous plant Radix Cyathulae.Function has expelling wind and removing dampness, restores menstrual flow and invigorates blood circulation.Chinese traditional treatment rheumatism lumbocrural pain, foot flaccidity clonic spasm of the muscle, stranguria with blood, hematuria, women's amenorrhea, the diseases such as lump in the abdomen.
Myrrha, has another name called myrrh, also known as bright Myrrha, and Myrrha (processed), Myrrha (processed), Myrrha (parched with vinegar), Myrrha, the another names such as raw bright Myrrha.Cure mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.There is the effect such as promoting blood circulation and stopping pain, detumescence and promoting granulation.
Radix Aconiti Preparata, Chinese name is because deriving from Radix Aconiti, and its another name goose is spent, the ornamental work of iron, the five poisonous creatures: scorpion, viper, centipede, house lizard, toad.Can expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, mastalgia, chest pain with distension sensation, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Cortex Cinnamomi, the in the form of slot or drum of this product, long 30 ~ 40cm, wide or diameter 3 ~ 10cm, thick 0.2 ~ 0.8cm.Outer surface taupe brown, slightly coarse, there is the hole skin of irregular fine wrinkle and transverse projections, pungent, sweet, hot greatly.Return kidney, spleen, the heart, Liver Channel.There is benefit fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, effect of promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Rhizoma Zingiberis, this product is flat bulk, tool finger-like branch, long 3 ~ 7cm, thick 1 ~ 2cm.Surface lark or grayish brown, coarse, tool indulges wrinkle and obvious link.Bifurcation often has scale leaf remaining, and there are stem trace or bud in branch top.Pungent, hot.Return spleen, stomach, kidney, the heart, lung meridian.Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting diarrhea, cold extremities faint pulse, phlegm retention is breathed with cough.
Herba Asari, pungent, temperature.GUIXIN, lung, kidney channel.There is expelling wind and cold, understand things pain-stopping, effect of warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
Fructus Evodiae, pungent, bitter, heat; Slightly poisonous.Return liver, spleen, stomach, kidney channel.There is dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, effect of supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension.
In said medicine, Radix Angelicae Sinensis primary efficacy is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, outstanding kind treatment rheumatic arthralgia, injury from falling down, ulcer sores; The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent; Be monarch drug altogether with Radix Angelicae Sinensis two medicine.Radix Notoginseng dissipating blood stasis stops blooding, subduing swelling and relieving pain; Flos Carthami promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain; Radix Dipsaci tonifying liver, bone and muscle strengthening, determines meridians, and only in warp, (muscles and bones) is ached; Radix Cyathulae expelling wind and removing dampness, restores menstrual flow and invigorates blood circulation, and four medicines are ministerial drug altogether.Radix Angelicae Pubescentis specially manages part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels rheumatism, two pain in foot numbness; Rhizoma Et Radix Notopterygii warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI; Herba Lycopodii Eradicates rheumatism, enters the especially kind the meridian dredging of liver; Radix Puerariae expelling wind and removing dampness, promoting blood circulation and stopping pain; Myrrha regulating qi and activating blood, detumescence and promoting granulation; Radix Aconiti Preparata expelling wind and removing dampness, antalgic is adjuvant drug altogether.Radix Saposhnikoviae expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic, Herba Asari expelling wind and cold, understand things pain-stopping, Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, Cortex Cinnamomi dispersing cold for relieving pain, and promoting blood circulation to restore menstrual flow is for making medicine.Full side's efficient combination, supports mutually, and select YAOJING thin, prescription is rigorous, and compatibility is precise and appropriate, plays wind expelling stagnation removing altogether, the effect of promoting blood circulation and stopping pain.The party also through clinical practice, achieves good result, and its interrelated data is as follows:
select the standard of case
1 physical data
1 years January in 2011, December used medicine of the present invention to treat the routine patient of rheumatism 100, male 42 example, women 58 example, age reckling 18 years old, the maximum 49 years old, 34.4 years old mean age; The shortest person of the course of disease 3 months, most elder 12 years.
diagnostic criteria
Formulate with reference to " new Chinese medicine guideline of clinical investigations ", " internal medicine " (the 6th edition).Rheumatism is one group, and to invade joint, skeleton, muscle, blood vessel and relevant soft tissue or connective tissue be the disease led, and wherein majority is autoimmune disease.Morbidity is much more hidden and slow, and the course of disease is longer, and mostly has genetic predisposition.Serological testing (antinuclear antibody), the Diagnosis and differential diaggnosis of rheumatoid factor inspection to rheumatism have very important significance.
clinical manifestation
(1) rheumatism has arthropathy and symptom mostly, can up to 70-80%, and about 50% only has pain, heavy then red, swollen, heat, pain and comprehensive inflammation performance such as function is impaired; Mostly be multi-joint to get involved.Invade and joint neglect greatly disease plant and have difference.
(2) heterogeneous, namely same disease, has different subtype, and due to genetic background, pathogenic factor is different, and mechanism is also different, the type of thus clinical manifestation, symptom, and weight and therapeutic response are also not quite similar.
(3) mostly rheumatism is to invade the disease of multisystem, and the pathology of numerous disease has overlap more, and symptom is similar, as MCTD(mixed connective tissue disease) be the typical case of this performance.
(4) there is Multiple Antibodies and immune complex (CIC) in serum, and can be deposited in tissue (skin, synovial membrane) or organ (kidney, liver) pathogenic.
(5) Raynaud phenomenon often comes across this class disease, as SLE(lupus erythematosus), MCTD(systemic lupus erythematosus (sle)).
include in and exclusion standard
Inclusive criteria: meet rheumatism diseases diagnostic standard.Age 18-50 year between, morning is stiff, the symmetrical rest pain in joint, distortion, and the course of disease continues the shortest 3 months.Do not accept rheumatismal treatment within 1 month, do not use hormones preparation person within half a year, distortion joint is intact without damaged, without dermatosis.
Exclusion standard: merge malignant tumor, struvite and other endocrinopathyes person; Woman's menstrual cycle or menstrual period serious irregular person; Be associated with the severe primary diseases such as cardiovascular and cerebrovascular vessel, liver, kidney, hemopoietic system, or psychotic; Allergic constitution or oneself know such medicine or constituent allergy sufferers; Participating in other clinical drug trials person.
Therapeutic scheme: patient lies supine, first cleans painful area, and Chinese medicine composition ointment of the present invention is directly affixed on painful area.Often paying ointment and can paste 3 days, 1 day, interval, 20 days is a course for the treatment of.Check in every 3 weeks 1 time, suffers from more person's drug withdrawal, does not suffer from more person and continues medication treatment, 3-6 courses for the treatment of of maximum medication.Woman's menstrual phase stops external application.Subsides officina portion skin allergy person can stop using after 3 days or symptomatic treatment, then continues to use.Treatments period is stopped using other treatment medicine.
criterion of therapeutical effect and result
criterion of therapeutical effect
Work out by State Administration of Traditional Chinese Medicine's " Chinese medical disease Standardization of diagnosis and curative effect " and " guideline of clinical investigations of new Chinese medicine treatment rheumatoid arthritis ".
Cure: joint deformity and pain disappear, serum inspection or image check prompting rheumatism sign disappear, and within after drug withdrawal 3 months, do not recur.
Effective: joint deformity and pain disappear, serum inspection or image check prompting rheumatism sign change obviously or take a turn for the better.
Invalid: joint deformity and pain disappear, serum inspection or image check point out rheumatism sign unchanged.
therapeutic outcome
100 routine patients are after treatment., wherein clinical symptom disappearance, every test rating is all normal, follows up a case by regular visits in March and does not recur 53 examples; Clinical symptoms is clearly better, and every test rating is normal or routine close to normal 39; Clinical symptoms is improved, unstable 8 examples of curative effect.Cure rate is 53%, and improvement rate is 39%, and total effective rate is 92%.
conclusion
From above-mentioned situation: the present invention selects the approach of local application, selecting nontoxic, tasteless, Glycerin, being easy to the unguentum of Transdermal absorption is substrate.Summing up clinical on the basis of face and traditional exterior-applied prescription for many years, proposing Chinese Medicine and Clavicular O/W type dairy cow treatment rheumatism, Be very effective.Medicine passes through transhipment absorbed into serum by horny layer transhipment and epidermis deep layer blood capillary, simultaneously ointment can be partially formed a kind of perspiration and be difficult to the relative air-tight state of evaporation and diffusion, water content of stratum corneum is improved, and horny layer expand into porous state, is beneficial to drug osmotic.In Chinese medicine, fragrant ingredient can sting olive local vascular dilation, and blood flow accelerates, and is beneficial to drug osmotic and absorbs, can make local joint vasodilation, blood flow accelerates, and histiocyte membrane permeability increases, improve local organization Nutrition and Metabolism, promote tissue regeneration, produce analgesia, antiinflammation.Processing technology is easy, and cost is low, use safety, good effect, dose is constant, topical, slow release is even, uses Ointment in Treatment, easy and simple to handle, without toxicity, patient's no pain, is easy to accept, and cure rate is high, effective percentage reaches 92%, is the innovation on treatment rheumatism medicine, will makes great creative contribution to raising human health.
Claims (6)
1. the rheumatismal Chinese medicine composition for the treatment of, it is characterized in that, comprise the raw material of following weighing scale: Radix Angelicae Sinensis 13-17g, Rhizoma Chuanxiong 9-11g, Radix Notoginseng 9-11g, Flos Carthami 13-17g, Radix Dipsaci 9-11g, Radix Angelicae Pubescentis 9-11g, Rhizoma Et Radix Notopterygii 9-11g, Herba Lycopodii 13-17g, Radix Puerariae 11-17g, Radix Saposhnikoviae 13-17g, Radix Cyathulae 9-11g, Myrrha 9-11g, Radix Aconiti Preparata 4-6g, Cortex Cinnamomi 11-17g, Rhizoma Zingiberis 9-11g, Herba Asari 3-6g, Fructus Evodiae 11-19g.
2. one kind comprises Chinese medicine composition ointment according to claim 1, it is characterized in that, comprise the raw material of following weighing scale: Radix Angelicae Sinensis 13-17g, Rhizoma Chuanxiong 9-11g, Radix Notoginseng 9-11g, Flos Carthami 13-17g, Radix Dipsaci 9-11g, Radix Angelicae Pubescentis 9-11g, Rhizoma Et Radix Notopterygii 9-11g, Herba Lycopodii 13-17g, Radix Puerariae 11-17g, Radix Saposhnikoviae 13-17g, Radix Cyathulae 9-11g, Myrrha 9-11g, Radix Aconiti Preparata 4-6g, Cortex Cinnamomi 11-17g, Rhizoma Zingiberis 9-11g, Herba Asari 3-6g, Fructus Evodiae 11-19g, stearic acid 60g, glyceryl monostearate 20g, glycerol 50g, Oleum Ricini 100g, ethyl hydroxybenzoate 0.5g, triethanolamine 8g and distilled water 250mL.
3. a preparation method for Chinese medicine composition ointment as claimed in claim 2, is characterized in that, comprise the following steps:
(1) Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Notoginseng, Flos Carthami, Radix Dipsaci, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Herba Lycopodii, Radix Puerariae, Radix Saposhnikoviae, Radix Cyathulae, Myrrha, Radix Aconiti Preparata, Cortex Cinnamomi, Rhizoma Zingiberis, Herba Asari, Fructus Evodiae were pulverized 100 mesh sieves, mixing, obtains fine medicinal material powder, for subsequent use;
(2) stearic acid, tristerin and ethyl hydroxybenzoate are added in Oleum Ricini, be heated to 70 DEG C ~ 80 DEG C, stearic acid, glyceryl monostearate and ethyl hydroxybenzoate are dissolved in Oleum Ricini completely, obtain oily solution;
By glycerol and distilled water mixing, be heated to 50 DEG C ~ 60 DEG C, then add triethanolamine, stir, make glycerol, distilled water and triethanolamine mix homogeneously, obtain aqueous solution;
By oily solution and aqueous solution mix homogeneously, until be cooled to room temperature, obtain O/W type emulsifiable paste matrix;
(3) the fine medicinal material powder 20g taking step (1) adds in O/W type emulsifiable paste matrix 500g, stirs, to obtain final product.
4. a preparation method for Chinese medicine composition ointment as claimed in claim 3, is characterized in that, comprise the following steps:
(1) Radix Angelicae Sinensis 13g, Rhizoma Chuanxiong 9g, Radix Notoginseng 9g, Flos Carthami 13g, Radix Dipsaci 9g, Radix Angelicae Pubescentis 9g, Rhizoma Et Radix Notopterygii 9g, Herba Lycopodii 13g, Radix Puerariae 11g, Radix Saposhnikoviae 13g, Radix Cyathulae 9g, Myrrha 9g, Radix Aconiti Preparata 4g, Cortex Cinnamomi 11g, Rhizoma Zingiberis 9g, Herba Asari 3g, Fructus Evodiae 11g were pulverized 100 mesh sieves, mixing, obtain fine medicinal material powder, for subsequent use;
(2) stearic acid 60g, glyceryl monostearate 20g and ethyl hydroxybenzoate 0.5g are added in Oleum Ricini 100g, be heated to 70 DEG C, stearic acid, glyceryl monostearate and ethyl hydroxybenzoate are dissolved in Oleum Ricini completely, obtain oily solution;
Glycerol 50g and distilled water 250mL is mixed, is heated to 50 DEG C, then add triethanolamine 8g, stir, make glycerol, distilled water and triethanolamine mix homogeneously, obtain aqueous solution;
By oily solution and aqueous solution mix homogeneously, until be cooled to room temperature, obtain O/W type emulsifiable paste matrix;
(3) the fine medicinal material powder 20g taking step (1) adds in O/W type emulsifiable paste matrix 500g, stirs, to obtain final product.
5. a preparation method for Chinese medicine composition ointment as claimed in claim 3, is characterized in that, comprise the following steps:
(1) Radix Angelicae Sinensis 13-17g, Rhizoma Chuanxiong 10g, Radix Notoginseng 10g, Flos Carthami 15g, Radix Dipsaci 10g, Radix Angelicae Pubescentis 10g, Rhizoma Et Radix Notopterygii 10g, Herba Lycopodii 15g, Radix Puerariae 14g, Radix Saposhnikoviae 15g, Radix Cyathulae 10g, Myrrha 10g, Radix Aconiti Preparata 5g, Cortex Cinnamomi 14g, Rhizoma Zingiberis 10g, Herba Asari 5g, Fructus Evodiae 15g were pulverized 100 mesh sieves, mixing, obtain fine medicinal material powder, for subsequent use;
(2) stearic acid 60g, glyceryl monostearate 20g and ethyl hydroxybenzoate 0.5g are added in Oleum Ricini 100g, be heated to 75 DEG C, stearic acid, glyceryl monostearate and ethyl hydroxybenzoate are dissolved in Oleum Ricini completely, obtain oily solution;
Glycerol 50g and distilled water 250mL is mixed, is heated to 55 DEG C, then add triethanolamine 8g, stir, make glycerol, distilled water and triethanolamine mix homogeneously, obtain aqueous solution;
By oily solution and aqueous solution mix homogeneously, until be cooled to room temperature, obtain O/W type emulsifiable paste matrix;
(3) the fine medicinal material powder 20g taking step (1) adds in O/W type emulsifiable paste matrix 500g, stirs, to obtain final product.
6. a preparation method for Chinese medicine composition ointment as claimed in claim 3, is characterized in that, comprise the following steps:
(1) Radix Angelicae Sinensis 17g, Rhizoma Chuanxiong 11g, Radix Notoginseng 11g, Flos Carthami 17g, Radix Dipsaci 11g, Radix Angelicae Pubescentis 11g, Rhizoma Et Radix Notopterygii 11g, Herba Lycopodii 17g, Radix Puerariae 17g, Radix Saposhnikoviae 17g, Radix Cyathulae 11g, Myrrha 11g, Radix Aconiti Preparata 6g, Cortex Cinnamomi 17g, Rhizoma Zingiberis 11g, Herba Asari 6g, Fructus Evodiae 19g were pulverized 100 mesh sieves, mixing, obtain fine medicinal material powder, for subsequent use;
(2) stearic acid 60g, glyceryl monostearate 20g and ethyl hydroxybenzoate 0.5g are added in Oleum Ricini 100g, be heated to 80 DEG C, stearic acid, glyceryl monostearate and ethyl hydroxybenzoate are dissolved in Oleum Ricini completely, obtain oily solution;
Glycerol 50g and distilled water 250mL is mixed, is heated to 60 DEG C, then add triethanolamine 8g, stir, make glycerol, distilled water and triethanolamine mix homogeneously, obtain aqueous solution;
By oily solution and aqueous solution mix homogeneously, until be cooled to room temperature, obtain O/W type emulsifiable paste matrix;
(3) the fine medicinal material powder 20g taking step (1) adds in O/W type emulsifiable paste matrix 500g, stirs, to obtain final product.
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