CN102416126A - Traditional Chinese medicine composition for treating Behcet's disease and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating Behcet's disease and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition for treating and a preparation method of a preparation thereof. The traditional Chinese medicine composition comprises the following raw medicinal materials in parts by weight: 18-22 parts of honeysuckle, 22-28 parts of eclipta alba, 18-22 parts of selfheal, 28-32 parts of glabrous greenbrier rhizome, 8-12 parts of golden cypress, 18-22 parts of Chinese angelica, 18-22 parts of manyleaf paris rhizome, 18-22 parts of hairyvein agrimony, 28-32 parts of loofah sponge, 22-28 parts of kadsura pepper stem, 28-32 parts of rehmannia root, 8-12 parts of liquorice, 8-12 parts of raw coix seed, 12-18 parts of lithospermum and 12-18 parts of sappan wood, decocting the raw materials with water, combining decoction, and concentrating to a proper amount. The Chinese medicine powder for treating the leukemia is prepared by uniformly mixing the fine powder of sappan wood, phellodendron amurense, glabrous greenbrier rhizome and borneol and sieving. Can relieve the clinical symptoms of Behcet's disease, and can obviously shorten the course of disease, and has obvious curative effect.
Description
Technical field
The present invention relates to a kind of Chinese drug-treated group mixture of treating behcets disease and preparation method thereof, belong to tcm field.
Background technology
Behcets disease mainly is with recurrent stomatocace, external genitalia ulcer and eye hypopyon property iridocyclitis, is the disease of characteristic; This disease is except invading oral cavity, external genitalia and eye; Also can involve joint, heart, blood vessel, digestive tract, lung, kidney and nervous system, be human commonly encountered diseases, frequently-occurring disease.See that with 16-40 year person between twenty and fifty the women is more than the male, morbidity can suddenly can be delayed more.Acute onset has General Symptomies such as heating, headache, weak, inappetence, arthralgia more, and oral cavity, reproduction ulcer and skin lesion often occur simultaneously.Chronic disease person General Symptoms can be not obvious, and oral cavity, genital ulcer and skin lesion can successively or repeatedly take place in half a year to several years.Show that according to interrelated data the sickness rate of behcets disease is 59.1%, gets behcets disease, see more that affected part pain can not be eaten maror unbearably, greatly reduces people's quality of life with oral cavity, genital ulcer and skin lesion.As when involving heart, blood vessel, digestive tract, lung, kidney and nervous system, can there be severe complications.Modern medicine is still not fully aware of to the etiology and pathogenesis understanding of primary disease, adopts Drug therapys such as adrenocortical hormone, immunosuppressant and colchicine in the treatment always, and side effect is big, and relapse rate is high.
Motherland's medical science is early on the books to primary disease, and stays many theoretical knowledgies and invaluable experience, record in the Zhang Zhongjing " golden your outline " " oral-anal-genital ulcer syndrome be disease; shape such as typhoid fever, desire for sleep quietly, order must not close; lying in bed restlessly, ulceration appearing in the throat is to delude, ulceration at external genitals is a Vulpes "; Sun Simiao " prescriptions worth thousand gold " is pointed out: " hu huo syndrome, its poison for puzzled sick, are that Vulpes sick cloudy anus person at larynx ".Traditional Chinese medical science method in treatment is also a lot, and how with the heat-clearing and toxic substances removing removing heat from blood, dampness is invigorated blood circulation; QI and blood regulating is main; But having many problems simultaneously, at first is that most clinical reports are in the experience introduction, selects for use identical method of treatment and essentially identical side's medicine to carry out the more of clinical and experimentation.The secondth, the case report is many, and system is few; Limitation person is effective, systemic weak effect.The 3rd is to use western medicine to have certain toxic and side effects and take for a long time human body is had certain hazardness, and prolonged application is easy to generate dependency, increases the dependency and the side effect of medicine, and curative effect descends gradually, and relapse rate is high.The present invention in conjunction with the modern medicine study method, sums up Chinese medicine of treatment behcets disease and preparation method thereof, in the clinical curative effect preferably that obtained on the empirical basis of forefathers.
Summary of the invention
The problem that the present invention will solve is to above deficiency, and Chinese drug-treated group mixture of simple, the eutherapeutic treatment behcets disease of a kind of method for preparing and preparation method thereof is provided.
For solving above technical problem, the technical scheme that the present invention adopted is: a kind of Chinese drug-treated group mixture of treating behcets disease is characterized in that: said Chinese medicine comprises the composition of following weight proportion:
Flos Lonicerae 18-22 part, Herba Ecliptae 22-28 part, Spica Prunellae 18-22 part, Rhizoma Smilacis Glabrae 28-32 part, Cortex Phellodendri 8-12 part, Radix Angelicae Sinensis 18-22 part, Rhizoma Paridis 18-22 part, Herba Agrimoniae 18-22 part, Retinervus Luffae Fructus 28-32 part, Caulis Piperis Kadsurae 22-28 part, Radix Rehmanniae 28-32 part, Radix Glycyrrhizae 8-12 part, living Semen Coicis 8-12 part, Radix Arnebiae (Radix Lithospermi) 12-18 part, Lignum Sappan 12-18 part.
Further improvement as technique scheme:
Said Chinese medicine comprises the composition of following weight proportion: 20 parts of Flos Loniceraes, 25 parts of Herba Ecliptaes, 20 parts of Spica Prunellaes, 30 parts of Rhizoma Smilacis Glabraes, 10 parts of Cortex Phellodendris, 20 parts of Radix Angelicae Sinensis, 20 parts of Rhizoma Paridis, 20 parts of Herba Agrimoniaes, 30 parts of Retinervus Luffae Fructuss, 25 parts of Caulis Piperis Kadsuraes, 30 parts in the Radix Rehmanniae, 10 parts in Radix Glycyrrhizae, 10 parts of living Semen Coiciss, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Lignum Sappans.
Said preparation method of Chinese medicine may further comprise the steps:
A, proportionally get each composition of raw material and mix, decocte with water 30 minutes water decoction;
B, get Lignum Sappan Cortex Phellodendri Rhizoma Smilacis Glabrae and be ground into fine powder altogether; Residue Lignum Sappan and Rhizoma Paridis, Retinervus Luffae Fructus,, the Radix Rehmanniae, Radix Glycyrrhizae, give birth to Semen Coicis, decocte with water three times, 1.5 hours for the first time, add 8 times of water gagings, 45 minutes second time; Add 6 times of water gagings, 30 minutes for the third time, add 6 times of water gagings, merge decoction liquor; Filter, leave standstill, draw supernatant, be concentrated into an amount of
C, all the other Radix Arnebiae (Radix Lithospermi) Flos Lonicerae Caulis Piperis Kadsurae Spica Prunellae Radix Angelicae Sinensis Herba Agrimoniae Herba Ecliptaes are with twice of 60% alcohol reflux; Each 1 hour; Add for the first time 8 times of amount ethanol, add 6 times of amount ethanol for the second time, extracting solution reclaims the alcohol back and merges with above-mentioned steps b concentrated solution; Be condensed into cream, (the general heat of the proportion of thick paste is surveyed (80-90 ℃) and recorded for 1.30-1.35).Spray drying is ground into fine powder, again with Lignum Sappan Cortex Phellodendri Rhizoma Smilacis Glabrae and the fine powder mix homogeneously, sieve, the sick Chinese medicine powder of white Sai Shi obtains medical treatment
D, the Chinese medicine powder that the white Sai Shi of obtaining medical treatment of above-mentioned steps c is sick add right amount of auxiliary materials, granulate, and are pressed into 1000, and the bag film-coat promptly gets tablet;
E, Chinese medicine powder that the white Sai Shi of obtaining medical treatment of above-mentioned steps c is sick add suitable amount of sucrose and dextrin, process granule, and drying is processed 1000 parts, obtains granule;
F, Chinese medicine powder that the white Sai Shi of the treatment of above-mentioned steps c is sick, the shift-in baking oven is dried to moisture for 50-70 ℃ and is lower than 5%, takes out, and crushing screening to 100 order obtains drug powder, adds adjuvant by prior art, processes capsule or enteric coated tablet;
G, proportionally get each composition of raw material and mix, pulverize, cross 80～100 mesh sieves, medicated powder; Get powder.Medicated powder after sieving used cold boiled water is general to be piller, cold drying, quality inspection, packing promptly gets watered pill;
H, get sucrose 90g in addition, add water 45ml and refined honey 90g, mix, refine when relative density is about 1.38 (70 ℃ record), filter,, rub the ball bar with the hands with the medicated powder mixing of above-mentioned steps b, pill piece, the pill grain, the heavy 9g of every ball promptly gets honey pill agent.
5, the method for preparing of Chinese medicine preparation as claimed in claim 4 is characterized in that step c method for concentration is: take by weighing vaseline, add lanoline, after the heating in water bath fusion, add 3 parts of sick Chinese medicine powder of the white Sai Shi of treatment and Borneolum Syntheticums, stir, put the cold ointment that promptly gets.
In the above raw material:
Flos Lonicerae, heat-clearing and toxic substances removing, wind-heat dissipating.Be used for the carbuncle furuncle, sore throat, erysipelas, warm blood fulminant dysentery, anemopyretic cold, epidemic febrile disease heating.Cure mainly affection due to external wind and heat, pestilence from the beginning of, skin infection furunculosis, red and swollen heat pain, passing stool with blood and pus " etc., external curing carbuncle furuncle abscess, trauma infection contamination, lingual surface ulcer, eczema etc.Modern medicine thinks to have antibiotic and antivirus action, promptly staphylococcus aureus etc. and influenza virus etc. is all had obvious inhibitory action.Flos Lonicerae can promote lymphocyte transformation, strengthens leukocytic phagocytic function, has the function of enhance immunity.Can promote the release of adrenocortical hormone, nonspecific inflammation is had obvious inhibitory action.
Herba Ecliptae, nourishing YIN and supplementing the kidney, cooling blood for hemostasis are applicable to prospects, stranguria with turbid discharge of the hepatic and renal YIN deficiency etc.Modern age, pharmacological research was thought, it can improve animal cell immunity and humoral immune function, thereby immunologic function is exerted an influence.
Spica Prunellae, liver heat removing and eyesight improving, heat clearing away eliminating stagnation, diuresis; Control diseases such as pestilence, acute mastitis, ophthalmalgia, gonorrhea.Be used for that lymphoid tuberculosis, thyromegaly, scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia are shed tears, bones and muscles pain.There is antibacterial that inhibitory action and dispersing tumor effect are arranged." the southern regions of the Yunnan Province book on Chinese herbal medicine ": the row irritability, open stagnation of liver-QI, end bones and muscles pain, ophthal malgia, the scrofula of loosing is stolen, whole body tuberculosis." Bencao Congxin ": control scrofula, scrofula, goiter, disease heavily fortified point, acute mastitis, breast carcinoma.
Rhizoma Smilacis Glabrae, dehumidifying, detoxifcation, easing joint movement.Be used for damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies, limbs contracture, bones and muscles pain, scrofula is festered, hydrarthrosis.
Cortex Phellodendri, effects such as tool heat clearing and damp drying, eliminating fire and detoxication.Cure mainly: hygropyretic dysentery, have loose bowels, jaundice, nocturnal emission, stranguria with turbid discharge, leukorrhagia, hectic fever due to YIN-deficiency consumptive fever, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, skin sore, skin eczema, be usually used in diseases such as leucorrhea and pyretic arthralgia, pyretic stranguria.The external curing pruritus vulvae, burn and scald, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, skin sore, skin noxious dampness, diseases such as skin infection.The effect of antibiotic, convergence, antiinflammatory is arranged
Radix Angelicae Sinensis is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.External curing injury from falling down, ulcer sores.
Rhizoma Paridis, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, three worms remove snake venom down.Be used to treat that skin ulcer is too fat to move, laryngopharynx swelling and pain, the erosion of the vulva, venom, fall and pounce on the pain of injury and convulsion with spasms.Also be used for venom, traumatic hemorrhage.
Herba Agrimoniae, astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, detoxifcation.Be used for carbuncle knot poison, hemoptysis, malaria, dysentery, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia.
Retinervus Luffae Fructus, clearing away heat and cooling blood, the detoxifcation of dispeling the wind, promoting the circulation of blood collateral dredging.Be used to treat diseases such as costa sternales pain, the mastalgia of QI and blood retardance be swollen.Can make skin fine and smooth, also have the itching relieving effect.
Caulis Piperis Kadsurae, wind-damp dispelling, the meridian dredging is regulated the flow of vital energy.Control anemofrigid-damp arthralgia, arthralgia, the contracture of muscle arteries and veins, traumatic injury, asthma, chronic cough.
The Radix Rehmanniae, removing heat from blood YIN nourishing, heat clearing away, promoting the production of body fluid to quench thirst.Cure mainly the hectic fever due to YIN-deficiency consumptive fever, epidemic febrile disease is sent out speckle, calentura excessive thirst, hematuria, is had blood in stool.Modern pharmacological research has radioprotective, protects the liver, blood sugar lowering, heart tonifying, hemostasis, diuresis, antifungal effect.
Radix Glycyrrhizae, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, ulcer sores, laryngopharynx swelling and pain etc.Cushion toxicity, strong.
Give birth to Semen Coicis, inducing diuresis to remove edema, spleen invigorating are dried, arthralgia relieving by relaxing muscles and tendons, clearing away heat and discharging pus.Be used for edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen.Be used for skin and make skin smooth, reduce wrinkle, eliminate the effect of pigment spot, face acne and pachylosis are had tangible curative effect.Modern medicine study is thought and is contained the rich in protein amylase in the Semen Coicis, can make skin keratin softening, eliminates skin wart, coarse rough.
Radix Arnebiae (Radix Lithospermi), clearing away heat and cooling blood is invigorated blood circulation, the detoxifcation rash.Be used for that heat in blood poison is contained, purple black, the measles without adequate eruption of macule, skin infection, erysipelas, eczema, burn due to hot liquid or fire, constipation with heat retention.Modern medicine thinks to have immunoregulation effect and antitumor action.
Lignum Sappan, promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.Be used for the amenorrhea dysmenorrhea, postpartum stagnation, breast ventral spine pain, wound swells and ache.Function type of having Flos Carthami, few with then can and blood, many with then can removing blood stasis.Have immunoregulation effect and antitumor action.
Borneolum Syntheticum, the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain, logical all keys, the stagnated fire of loosing goes nebula to make eye bright, reducing swelling and alleviating pain.Control the apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, conjunctival congestion and swelling pain, sore throat aphtha, enterobiasis.The inside and outside hemorrhoid of external curing, carbuncle, aphtha, skin infection swells and ache, and does not hold back laryngopharynx swelling and pain, aphtha of the mouth and tongue after bursting.Be transdermal agent preferably, and the pain relieving antisepsis is arranged.
The present invention uses Flos Lonicerae, Herba Ecliptae, Spica Prunellae, Rhizoma Paridis, Rhizoma Smilacis Glabrae, Cortex Phellodendri and Retinervus Luffae Fructus heat-clearing and toxic substances removing, and dispersing swelling and dissipating binds has stronger antibiotic, antiinflammatory, detumescence effect, to the carbuncle furuncle, laryngopharynx swelling and pain, erysipelas, the erosion of the vulva etc. have curative effect preferably.Chinese angelica blood supplementing is invigorated blood circulation, ability dispelling the wind and dampness pathogens arthralgia pain, traumatic injury, ulcer sores; Strengthen local blood circulation simultaneously, promote microcirculation, promote inflammation, the effect that swollen thing absorbs.The Herba Agrimoniae astringing to arrest bleeding cures mainly carbuncle sore tumefacting virus, metrostaxis, malaria, dysentery.The Caulis Piperis Kadsurae wind-damp dispelling, the meridian dredging, to anemofrigid-damp arthralgia, arthralgia, the contracture of muscle arteries and veins has important function.The YIN nourishing of Radix Rehmanniae removing heat from blood, heat clearing away cures mainly the hectic fever due to YIN-deficiency consumptive fever, and epidemic febrile disease is sent out speckle.Give birth to Semen Coicis inducing diuresis to remove edema, spleen invigorating dehumidifying, arthralgia relieving by relaxing muscles and tendons, clearing away heat and discharging pus, can improve the arthralgia chiefly caused by damp pathogen contracture.Behcets disease is a pathologic basis with the minute blood vessel inflammation, Lignum Sappan and the similar Flos Carthami of Radix Arnebiae (Radix Lithospermi) function, blood circulation promoting and blood stasis dispelling; Promoting the flow of QI in the collateral by warming the meridian, subduing inflammation relieve the pain bitterly, can improve the thrombophlebitis or the arteritis obliterans of clinical appearance; And have immunoregulation effect, immunologic function is exerted an influence.The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing is removed the anxious pain of extremity contraction, ulcer sores, laryngopharynx swelling and pain etc., coordinating the actions of various ingredients in a prescription, cushion toxicity.Borneolum Syntheticum external infiltration mucosa and skin, the clearing heat for detumescence pain relieving, antibiotic, promote the effect of ulcer healing.
The present invention adopts above technical scheme, compared with prior art, has the following advantages: the raw material of Chinese medicine of the present invention belongs to Chinese herbal medicine commonly used, and it is convenient to buy, and low price, manufacture method are simple; Because each reasonable mixture ratio of components of raw material makes the organic compatibility of each component, action compensating.Clinical observation confirms to have no side effect, and is evident in efficacy, and oral ulcer, vulval ulcer and skin nodules property erythema are had the effect of obvious treatment, according to clinical trial, faces the control rate more than 37%, total effective rate 100%.
Below in conjunction with embodiment the present invention is described further.
The specific embodiment
Embodiment 1: a kind of Chinese medicine of treating behcets disease comprises the composition of following weight proportion: 18 parts of Flos Loniceraes, 22 parts of Herba Ecliptaes, 18 parts of Spica Prunellaes, 28 parts of Rhizoma Smilacis Glabraes, 8 parts of Cortex Phellodendris, 18 parts of Radix Angelicae Sinensis, 18 parts of Rhizoma Paridis, 18 parts of Herba Agrimoniaes, 28 parts of Retinervus Luffae Fructuss, 22 parts of Caulis Piperis Kadsuraes, 28 parts in the Radix Rehmanniae, 8 parts in Radix Glycyrrhizae, give birth to 4 parts of 8 parts of Semen Coiciss, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 12 parts of Lignum Sappans and Borneolum Syntheticums.
This Chinese medicine prepares according to following steps:
A, proportionally get each composition of raw material and mix, decocte with water 30 minutes water decoction;
B, get Lignum Sappan Cortex Phellodendri Rhizoma Smilacis Glabrae and be ground into fine powder altogether; Residue Lignum Sappan and Rhizoma Paridis, Retinervus Luffae Fructus,, the Radix Rehmanniae, Radix Glycyrrhizae, give birth to Semen Coicis, decocte with water three times, 1.5 hours for the first time, add 8 times of water gagings, 45 minutes second time; Add 6 times of water gagings, 30 minutes for the third time, add 6 times of water gagings, merge decoction liquor; Filter, leave standstill, draw supernatant, be concentrated into an amount of
c、。All the other Radix Arnebiae (Radix Lithospermi) Flos Lonicerae Caulis Piperis Kadsurae Spica Prunellae Radix Angelicae Sinensis Herba Agrimoniae Herba Ecliptaes are with twice of 60% alcohol reflux; Each 1 hour; Add for the first time 8 times of amount ethanol, add 6 times of amount ethanol for the second time, extracting solution reclaims the alcohol back and merges with above-mentioned steps b concentrated solution; Be condensed into cream, (the general heat of the proportion of thick paste is surveyed (80-90 ℃) and recorded for 1.30-1.35).Spray drying is ground into fine powder, again with Lignum Sappan Cortex Phellodendri Rhizoma Smilacis Glabrae and the fine powder mix homogeneously, sieve, the sick Chinese medicine powder of white Sai Shi obtains medical treatment
D, the Chinese medicine powder that the white Sai Shi of obtaining medical treatment of above-mentioned steps c is sick add right amount of auxiliary materials, granulate, and are pressed into 1000, and the bag film-coat promptly gets;
E, Chinese medicine powder that the white Sai Shi of obtaining medical treatment of above-mentioned steps c is sick add suitable amount of sucrose and dextrin, process granule, and drying is processed 1000 parts, obtains granule;
F, Chinese medicine powder that the white Sai Shi of the treatment of above-mentioned steps c is sick, the shift-in baking oven is dried to moisture for 50-70 ℃ and is lower than 5%, takes out, and crushing screening to 100 order obtains drug powder, adds adjuvant by prior art, processes capsule or enteric coated tablet;
G, proportionally get each composition of raw material and mix, pulverize, cross 80～100 mesh sieves, medicated powder; Promptly get powder.Medicated powder after sieving used cold boiled water is general to be piller, cold drying, quality inspection, packing promptly gets watered pill;
H, get sucrose 90g in addition, add water 45ml and refined honey 90g, mix, refine when relative density is about 1.38 (70 ℃ record), filter,, rub the ball bar with the hands with the medicated powder mixing of above-mentioned steps b, pill piece, the pill grain, the heavy 9g of every ball promptly gets honey pill agent.
5, the method for preparing of Chinese medicine preparation as claimed in claim 4 is characterized in that step c method for concentration is: take by weighing vaseline, add lanoline, after the heating in water bath fusion, add 3 parts of sick Chinese medicine powder of the white Sai Shi of treatment and Borneolum Syntheticums, stir, put the cold ointment that promptly gets.
Embodiment 2: a kind of Chinese medicine of treating behcets disease comprises the composition of following weight proportion: 20 parts of Flos Loniceraes, 25 parts of Herba Ecliptaes, 20 parts of Spica Prunellaes, 30 parts of Rhizoma Smilacis Glabraes, 10 parts of Cortex Phellodendris, 20 parts of Radix Angelicae Sinensis, 20 parts of Rhizoma Paridis, 20 parts of Herba Agrimoniaes, 30 parts of Retinervus Luffae Fructuss, 25 parts of Caulis Piperis Kadsuraes, 30 parts in the Radix Rehmanniae, 10 parts in Radix Glycyrrhizae, give birth to 6 parts of 10 parts of Semen Coiciss, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Lignum Sappans and Borneolum Syntheticums.
Method for preparing is with embodiment 1.
Embodiment 3: a kind of Chinese medicine of treating behcets disease comprises the composition of following weight proportion: 22 parts of Flos Loniceraes, 28 parts of Herba Ecliptaes, 22 parts of Spica Prunellaes, 32 parts of Rhizoma Smilacis Glabraes, 12 parts of Cortex Phellodendris, 22 parts of Radix Angelicae Sinensis, 22 parts of Rhizoma Paridis, 22 parts of Herba Agrimoniaes, 32 parts of Retinervus Luffae Fructuss, 28 parts of Caulis Piperis Kadsuraes, 32 parts in the Radix Rehmanniae, 12 parts in Radix Glycyrrhizae, give birth to 8 parts of 12 parts of Semen Coiciss, 18 parts of Radix Arnebiae (Radix Lithospermi)s, 18 parts of Lignum Sappans and Borneolum Syntheticums.
Method for preparing is with embodiment 1.
Efficacy assessment standard:
Before and after receive treatment all to oral ulcer, external genitalia ulcer, the eye infringement, main clinical manifestation such as skin nodules erythema, folliculitis appearance erythra, acneform eruptions, acupuncture reaction and arthropathy are carried out observed and recorded, and carry out efficacy evaluation.
Clinic control: mouth, eye, genitals and skin symptom treatment were all eliminated in 3 months, did not have the recidivist in 1 year.
Produce effects: mouthful, eye, the treatment of genitals and skin symptom eliminated in 3 months, and in 6 months to 1 year the recidivist.
Effectively: mouth, eye, genitals and skin symptom treatment took a turn for the better the drug withdrawal person of increasing the weight of in 3 months.
Invalid: mouth, eye, genitals and 3 months nonresponders of skin symptom treatment.
Method for using:
1, take capsule, every day 3 times, each 2, one after each meal, plain boiled water is taken after mixing it with water.3 months was 1 course of treatment.
2, have oral ulcer and vulval ulcer person to use bottled powder, cotton rod dips in a little in ulcer surface, every day three times.
3, nodosity property erythema person uses the ointment affected part of exterior coating, uses the warm water cleaning affected part earlier during use, and an amount of accent of the cream of getting it filled again applied every day 3 times.
Choose the 100 routine behcets disease patients treatment that makes an experiment, male 41 examples, women 59 examples.
Therapeutic Method: adopt capsule, powder and unguentum way of combining to treat.
Contrast test: choose 400 routine behcets disease patients, be divided at random and observe 1 group of 100 example, observe 2 group of 100 example, observe 3 group of 100 example, matched group 100 examples.Observing 1 group uses capsule, powder and the unguentum of the embodiment of the invention 1 preparation to treat; Observe 2 groups and use capsule, powder and the unguentum of the embodiment of the invention 2 preparations to treat, observe 3 groups and use capsule, powder and the unguentum of the embodiment of the invention 3 preparations to treat.
The patient of matched group adopts enteric coated aspirin, Radix Salviae Miltiorrhizae Injection and colchicine to treat.
Therapeutic outcome such as following table:
Can find out that from above tables of data 2 nonresponders are organized in treatment has 0 example, produce effects 53 examples account for 53%.Effective 7 examples account for 7%, and clinic control 40 examples account for 40%, clinic control rate 40%, and the matched group nonresponder has 0 example, and produce effects 44 examples account for 44%.Effective 29 examples account for 29%, clinic control 27 examples; Account for 27%, clinic control rate 27%, treatment group obvious effective rate clinic control rate is apparently higher than matched group; The obvious effective rate clinic control rate of treatment group 2 is higher than all the other treatment groups 1 and treatment groups 3, and to organize 2 prescriptions the most effective in treatment in sum.
Claims (5)
1. Chinese medicine composition of treating behcets disease is characterized in that: said medicine is processed Flos Lonicerae 18-22 part, Herba Ecliptae 22-28 part, Spica Prunellae 18-22 part, Rhizoma Smilacis Glabrae 28-32 part, Cortex Phellodendri 8-12 part, Radix Angelicae Sinensis 18-22 part, Rhizoma Paridis 18-22 part, Herba Agrimoniae 18-22 part, Retinervus Luffae Fructus 28-32 part, Caulis Piperis Kadsurae 22-28 part, Radix Rehmanniae 28-32 part, Radix Glycyrrhizae 8-12 part, is given birth to Semen Coicis 8-12 part, Radix Arnebiae (Radix Lithospermi) 12-18 part, Lignum Sappan 12-18 part by the raw material of following weight portion.
2. the Chinese medicine composition that is used to treat behcets disease as claimed in claim 1 is characterized in that: said raw-material weight part is following: 20 parts of Flos Loniceraes, 25 parts of Herba Ecliptaes, 20 parts of Spica Prunellaes, 30 parts of Rhizoma Smilacis Glabraes, 10 parts of Cortex Phellodendris, 20 parts of Radix Angelicae Sinensis, 20 parts of Rhizoma Paridis, 20 parts of Herba Agrimoniaes, 30 parts of Retinervus Luffae Fructuss, 25 parts of Caulis Piperis Kadsuraes, 30 parts in the Radix Rehmanniae, 10 parts in Radix Glycyrrhizae, 10 parts of living Semen Coiciss, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Lignum Sappans.
3. according to claim 1 or claim 2 the Chinese medicine composition that is used to treat behcets disease, it is characterized in that: said pharmaceutical dosage form is: water decoction, ointment, powder, capsule, tablet, granule, watered pill, honey pill agent or enteric coated tablet.
4. the method for preparing of claim 1 or 2 described Chinese medicinal composition preparation may further comprise the steps:;
A, proportionally get each composition of raw material and mix, decocte with water 30 minutes water decoction;
B, get Lignum Sappan Cortex Phellodendri Rhizoma Smilacis Glabrae and be ground into fine powder altogether; Residue Lignum Sappan and Rhizoma Paridis, Retinervus Luffae Fructus,, the Radix Rehmanniae, Radix Glycyrrhizae, give birth to Semen Coicis, decocte with water three times, 1.5 hours for the first time, add 8 times of water gagings, 45 minutes second time; Add 6 times of water gagings, 30 minutes for the third time, add 6 times of water gagings, merge decoction liquor; Filter, leave standstill, draw supernatant, be concentrated into an amount of
c、。All the other Radix Arnebiae (Radix Lithospermi) Flos Lonicerae Caulis Piperis Kadsurae Spica Prunellae Radix Angelicae Sinensis Herba Agrimoniae Herba Ecliptaes are with twice of 60% alcohol reflux; Each 1 hour; Add for the first time 8 times of amount ethanol, add 6 times of amount ethanol for the second time, extracting solution reclaims the alcohol back and merges with above-mentioned steps b concentrated solution; Be condensed into cream, (the general heat of the proportion of thick paste is surveyed (80-90 ℃) and recorded for 1.30-1.35).Spray drying is ground into fine powder, again with Lignum Sappan Cortex Phellodendri Rhizoma Smilacis Glabrae and the fine powder mix homogeneously, sieve, the sick Chinese medicine powder of white Sai Shi obtains medical treatment
D, the Chinese medicine powder that the white Sai Shi of obtaining medical treatment of above-mentioned steps c is sick add right amount of auxiliary materials, granulate, and are pressed into 1000, and the bag film-coat promptly gets;
E, Chinese medicine powder that the white Sai Shi of obtaining medical treatment of above-mentioned steps c is sick add suitable amount of sucrose and dextrin, process granule, and drying is processed 1000 parts, obtains granule;
F, Chinese medicine powder that the white Sai Shi of the treatment of above-mentioned steps c is sick, the shift-in baking oven is dried to moisture for 50-70 ℃ and is lower than 5%, takes out, and crushing screening to 100 order obtains drug powder, adds adjuvant by prior art, processes capsule or enteric coated tablet;
G, proportionally get each composition of raw material and mix, pulverize, cross 80～100 mesh sieves, medicated powder; Promptly get powder.Medicated powder after sieving used cold boiled water is general to be piller, cold drying, quality inspection, packing promptly gets watered pill;
H, get sucrose 90g in addition, add water 45ml and refined honey 90g, mix, refine when relative density is about 1.38 (70 ℃ record), filter,, rub the ball bar with the hands with the medicated powder mixing of above-mentioned steps b, pill piece, the pill grain, the heavy 9g of every ball promptly gets honey pill agent.
5. the method for preparing of Chinese medicine preparation as claimed in claim 4 is characterized in that step c method for concentration is: take by weighing vaseline, add lanoline, after the heating in water bath fusion, add 3 parts of sick Chinese medicine powder of the white Sai Shi of treatment and Borneolum Syntheticums, stir, put the cold ointment that promptly gets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100064150A CN102416126A (en) | 2012-01-10 | 2012-01-10 | Traditional Chinese medicine composition for treating Behcet's disease and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688347A (en) * | 2012-06-11 | 2012-09-26 | 张松波 | Traditional Chinese medicine preparation for treating oral inflammation and preparation method thereof |
| CN103479756A (en) * | 2012-11-20 | 2014-01-01 | 汉仲月 | Mucosa nursing matter for Behcet's syndromes |
| CN103520508A (en) * | 2013-10-25 | 2014-01-22 | 刘晓伟 | Traditional Chinese medicine for treating intestinal behcet disease |
| CN104997956A (en) * | 2015-07-30 | 2015-10-28 | 庞群 | Behcet's syndrome and treatment drug thereof |
-
2012
- 2012-01-10 CN CN2012100064150A patent/CN102416126A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688347A (en) * | 2012-06-11 | 2012-09-26 | 张松波 | Traditional Chinese medicine preparation for treating oral inflammation and preparation method thereof |
| CN103479756A (en) * | 2012-11-20 | 2014-01-01 | 汉仲月 | Mucosa nursing matter for Behcet's syndromes |
| CN103479756B (en) * | 2012-11-20 | 2015-05-06 | 青岛市中心医院 | Mucosa nursing matter for Behcet's syndromes |
| CN103520508A (en) * | 2013-10-25 | 2014-01-22 | 刘晓伟 | Traditional Chinese medicine for treating intestinal behcet disease |
| CN104997956A (en) * | 2015-07-30 | 2015-10-28 | 庞群 | Behcet's syndrome and treatment drug thereof |
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Application publication date: 20120418 |