CN103520654A - Chinese medicine composition for treating knee osteoarthritis and preparation method of Chinese medicine composition - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating knee osteoarthritis. Various raw materials in the traditional Chinese medicine composition are: angelica, mulberry, chuanxiong, notopterygium, lovage, gentiana, cassia twig, frankincense, woody, mulberry Twig, Agrimony, Eucommia, Rehmannia glutinosa, Corydalis Corydalis, Tibetan Clove, Millet Spatholobus, Achyranthes bidentata, Sanleng, Curcuma, Aconite, Curculigo, Morinda officinalis, Soap Kernel, Salvia, Safflower, Rhubarb, Panax notoginseng, Su Wood, Deergrass, Skewer Liver, Scorpion Vine and Sea Breeze Vine. The present invention has the traditional Chinese medicine treatment of knee osteoarthritis, mainly tonifying the kidney and strengthening the bones, dredging collaterals to relieve pain, promoting blood circulation and removing blood stasis, expelling wind and cold, etc.; and the production process is simple, the toxic and side effects are small, the administration is convenient, the medicament is easy to manufacture, and the cost is low. Inexpensive new drugs.

Description

A kind of traditional Chinese medicine composition for treating knee osteoarthritis and preparation method thereof

the

technical field

The invention relates to a medical preparation containing raw materials derived from plants, animals or minerals, in particular to a traditional Chinese medicine composition for treating knee osteoarthritis and a preparation method thereof.

the

Background technique

Osteoarthritis is a chronic joint disease, and its main changes are degeneration of articular cartilage surface and secondary bone hyperplasia. The main manifestations are joint pain and inflexibility. X-rays show that the joint space is narrowed, the subchondral bone is dense, the trabecular bone is broken, and there are sclerosis and cystic degeneration. Lip-like hyperplasia at the joint margin. In the late stage, the bone end deforms and the articular surface is uneven. The cartilage in the joint peels off, and the bone fragments enter the joint, forming loose bodies in the joint. Osteoarthritis is also called degenerative arthritis. It is actually not inflammation, but mainly degeneration. It belongs to premature aging of joints, especially the aging of articular cartilage. Osteoarthritis represents the aging of joints, so it is called senile arthritis. (1) Chinese medicine's understanding of the disease name of knee osteoarthritis

Knee osteoarthritis belongs to the category of "bone numbness" and "lumbar and leg pain" in traditional Chinese medicine. "Criteria for Syndrome and Treatment" says: "The upper and lower legs are thin, but the knee is larger, shaped like a crane's knee." It points out that the clinical symptoms of "crane's knee wind" are similar to knee swelling and tibial atrophy in the late stage of knee arthritis. "Su Wen·Changci Jie Lun" said: "The disease lies in the bones, the bones are too heavy to lift, the bone marrow is sore, and the cold air is coming, which is called bone numbness." The guard does not live, the flesh shrinks the tendons, the ribs and elbows cannot be stretched, the inside is bone numbness, and the outside is inhumane." "Qian Jin Fang" pointed out that the further development of bone numbness will involve the kidneys and become "bone poles". "Su Wen·Bi Lun" discusses the causes and clinical manifestations of Arthralgia Syndrome in detail, and puts forward the principles of "muscle paralysis", "skin paralysis", "pulse paralysis" and "bone paralysis" according to the parts of the disease that are affected by evils in the four seasons. The concept, based on the description of specific symptoms, "The numbness lies in the bones and it is heavy, the blood is astringent and does not flow when it lies in the pulse, it does not stretch when it lies in the tendons, it is not benevolent if it lies in the flesh, and it is cold if it lies in the skin." For example, the bone marrow is sore and cold, and the name is bone numbness"; "Jingyue Quanshu" says: "The one who is covered with numbness is closed, and the qi and blood are closed by evil, and the disease cannot be passed." "The syndrome of wind numbness is mostly Because there are many people who are deficient, but the qi and blood are not full, so the wind and cold can enter it, but the yin and evil stay, so the meridians are unfavorable." Therefore, it is proposed that "deficiency", "evil", "stasis" and the origin of the disease Relationship; Wang Qingren of the Qing Dynasty put forward the theory of congestion-induced numbness in "Yilin Gaicuo"; "Medical Classics Original Purpose" pointed out that "wind, cold, and dampness are mixed together, and they form numbness... Those who meet this in winter are bone numbness...so "Bone numbness is endless"; "Compendium of Medicine" says: "Those who feel wind, cold and dampness in winter are bone numbness, and if they persist for a long time, they will enter the kidneys"; , its qi prospers and nourishes the bone marrow, and now the kidney is deficient and suffers from wind and cold, so the knees are cold." "On the Causes and Symptoms of Various Diseases" says: "The liver governs the tendons and stores blood, and the kidney governs the bones to produce marrow. Deficiency and blood loss marrow, so it hurts the muscles and bones. Chao Yuanfang believes that the main cause of arthralgia syndrome is physical deficiency and pathogenic factors, which are caused by long-term exposure to wind, cold and damp pathogens on the basis of kidney deficiency; "There are all those who are not due to deficiency of the liver and kidney, and the deficiency causes wind and cold to attack it" related. It shows that the deficiency of liver and kidney and the deficiency of essence and blood are the root causes of knee osteoarthritis, and the invasion of wind, cold and dampness is the sign of knee osteoarthritis. At the same time, "Hua Tuo Shenfang" believes that "bone numbness is caused by insatiable appetite and injures the kidneys." It shows that the occurrence of knee osteoarthritis is also related to diet. Clinical diagnosis: 1. There has been knee soft tissue injury, but most people did not pay attention and have no memory at that time. 2. Knee joint pain and stiffness, more obvious when getting up in the morning, relieved after exercise, aggravated after prolonged exercise, and relieved after rest. 3. Pain persists in the late stage, joint activities are obviously limited, quadriceps atrophy, joint effusion, and even deformities and loose bodies in the joints appear. 4. Friction sounds can be palpable during knee flexion and extension activities. 5. Anteroposterior and lateral X-rays of the knee joint show lip-like bone hyperplasia on the joint border of the patella, femoral condyle, and tibial plateau, a sharp mutation of the tibial intercondyle, narrowing of the joint space, dense subchondral bone, and sometimes intra-articular free body. Therapeutic principles: The treatment of this disease with traditional Chinese medicine for knee osteoarthritis is mainly to invigorate the kidney and strengthen the bones, dredge collaterals to relieve pain, activate blood circulation and remove blood stasis, dispel wind and cold, and cooperate with acupuncture, laser, and external treatment.

Modern medicine believes that the detailed etiology is not clear at present, and it is clear that multiple factors cause the destruction of articular cartilage. It is often related to the following factors: ①Injury: such as articular cartilage injury caused by intra-articular fracture, meniscus injury, bone dislocation and other reasons. ② Excessive weight-bearing: excessive weight-bearing on the articular surface caused by obesity or knee varus or valgus deformity. ③ Infection or inflammation causes destruction of articular cartilage. ④ Subchondral osteonecrosis, such as loose bodies in the joint, causing damage to the articular cartilage surface.

Treatment of Knee Osteoarthritis ⑴ Promoting disease prevention knowledge and protecting joints: First of all, patients should be aware of the disease, and physical exercise should be carried out step by step to prevent excessive joint movement and weight bearing, and avoid mechanical damage to joints. In severe cases, braking or plaster fixation should be performed to prevent deformity. Lose weight, use handles, canes to take load off affected joints. Those related to occupation should change jobs. Exercises related to muscle groups can maintain and improve joint mobility to enhance joint stability. ⑵Physical therapy: hyperthermia, hydrotherapy, infrared, ultrashort wave, electrical stimulation, etc. can enhance local blood circulation, relieve muscle tension, relieve pain and other symptoms. Traction therapy has a better effect on patients with cervical spondylosis with nerve roots. It can relax muscles, relieve pain, and prevent the formation of adhesions between adjacent nerve roots, but it must be performed under the guidance of specialists. (3) Massage and traditional Chinese medicine: Traditional Chinese medicine massage and acupuncture have obvious effects in alleviating the symptoms of arthritis; existing traditional Chinese medicine plasters can promote blood circulation and relieve pain, and sometimes have good effects, but they have side effects and are prone to recurrence.

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Contents of the invention

The technical problem to be solved by the present invention is to provide a new drug with simple formula, simple manufacturing process, less toxic and side effects, convenient administration, easy manufacture of medicament, and low cost. The invention adopts traditional Chinese medicinal materials with different medicinal properties, carries out scientific compatibility, can achieve an ideal therapeutic effect, is safe, has little toxic and side effects, is simple to prepare, can directly reach the lesion, has short healing time, and is not easy to relapse after being cured.

In order to solve the above-mentioned technical problems, the present invention provides a kind of traditional Chinese medicine composition for treating knee osteoarthritis, the weight-number ratio of various raw materials in the traditional Chinese medicine composition is: Angelica sinensis 10～20 parts, Sangjisheng 10～20 parts. 25 parts, 10-25 parts of Rhizoma Chuanxiong, 10-20 parts of Notopterygium, 10-50 parts of Duhuo, 10-20 parts of Gentiana, 10-20 parts of Guizhi, 10-20 parts of frankincense, 10-20 parts of woody incense, 10 parts of Mori twig ～25 parts, Agrimony 10～20 parts, Eucommia 10～20 parts, Rehmannia glutinosa 10～20 parts, Corydalis Corydalis 10～20 parts, Tibetan clove 10-20 parts, Millipeda 10～20 parts, Achyranthes bidentata 10～25 parts 10-20 parts of trigonum, 10-20 parts of curcuma, 10-20 parts of aconite, 10-25 parts of curculigo, 10-25 parts of Morinda officinalis, 10-20 parts of soap core, 10-20 parts of salvia, red 10-25 parts of flowers, 10-20 parts of rhubarb, 10-20 parts of Panax notoginseng, 10-20 parts of sumac, 10-20 parts of cervus, 10-20 parts of cutting live, 10-20 parts of terrazzo, 10-20 parts of sea wind rattan.

The ratio of parts by weight of each raw medicinal material in the traditional Chinese medicine composition is preferably: 12-18 parts of angelica, 15-22 parts of mulberry, 12-23 parts of Chuanxiong, 12-17 parts of notopterygium, 17-42 parts of lovage, and 12 parts of Gentiana chinensis. ~18 parts, 12-18 parts of cinnamon sticks, 12-17 parts of frankincense, 11-19 parts of woody incense, 14-21 parts of mulberry branch, 11-18 parts of agrimony, 10-20 parts of Eucommia, 10-20 parts of Rehmannia glutinosa , 10-18 parts of Corydalis Corydalis, 13-17 parts of Tibetan Clove, 12-20 parts of Millet Spatholobus, 15-25 parts of Achyranthes bidentata, 12-20 parts of Trigonium, 12-20 parts of Curcuma, 10-20 parts of Aconite, curculigo 10-25 parts, 10-25 parts of Morinda officinalis, 12-17 parts of soap core, 10-20 parts of salvia miltiorrhiza, 10-25 parts of safflower, 10-20 parts of rhubarb, 10-20 parts of Panax notoginseng, 10-20 parts of sumac 20 parts, 10 to 20 parts of Cervus deerbita, 10 to 18 parts of cutting live, 13 to 17 parts of terrazzo vine, and 12 to 18 parts of sea wind vine.

The ratio of parts by weight of each raw material in the traditional Chinese medicine composition can also be preferably: 16 parts of Angelica sinensis, 18 parts of Sangjisheng, 17 parts of Rhizoma Chuanxiong, 15 parts of Notopterygium, 29 parts of Duhuo, 15 parts of Gentiana, 15 parts of Guizhi, frankincense 15 parts, wood fragrance 15 parts, mulberry branch 17 parts, Agrimony 15 parts, Eucommia 15 parts, Rehmannia glutinosa 14 parts, Corydalis 14 parts, Tibetan clove 15 parts, Milletanus 16 parts, Achyranthes bidentata 21 parts, trigonum 16 parts 16 parts of curcuma, 15 parts of aconite, 18 parts of curculigo, 17 parts of Morinda officinalis, 15 parts of soap core, 15 parts of salvia miltiorrhiza, 17 parts of safflower, 15 parts of rhubarb, 15 parts of notoginseng, 15 parts of sumac, deer There are 16 parts of the grass, 14 parts of the skewer, 14 parts of the vine, and 15 parts of the sea wind rattan.

In order to better realize the object of the above invention, the present invention also provides a preparation method of a Chinese medicine composition for the treatment of knee osteoarthritis, the dosage form of the Chinese medicine composition is a patch, and the preparation method comprises the following steps:

a. Take the raw medicinal materials in the above weight-number ratio and put them into ethanol to heat and reflux for extraction twice to obtain extract 1;

b. Then add water to heat and reflux the raw medicinal materials extracted by ethanol once to obtain extract 2;

c. Combine extract 1 and extract 2 and concentrate to obtain medicinal extract; heat and concentrate for preparation.

Wherein, in the step a, the raw medicinal materials weighed according to the weight-to-number ratio are added to 10 times the amount of 60-85% ethanol, heated and refluxed for 2 extractions, each time for 1-2 hours, and the extract is left to stand , to obtain the extract 1, and the dregs for subsequent use.

In the step b, the medicinal dregs extracted by ethanol in the step a are heated and refluxed twice for 1-2 hours each time, and the extracts are combined and left to stand to obtain the extract 2.

In the step c, the extract 1 and the extract 2 are combined, pumped into a decompression concentration tank, decompressed to 0.03-0.08MPa, kept at a temperature of 60-80°C, and concentrated until the temperature is 60°C-70°C The relative density is 1.20, heated and concentrated to a paste, mixed with wine, vinegar and honey to obtain a patch.

The present invention also provides a preparation method of a traditional Chinese medicine composition for treating knee osteoarthritis, the dosage form of the traditional Chinese medicine composition is a capsule, and the preparation method comprises the following steps: weighing all the raw materials Medicinal materials, crushed into coarse powder, further crushed, passed through a 100-120 mesh sieve, so that the amount of fine powder that can pass through the sieve reaches 30%, and the fine powder that passes through the sieve is collected to obtain fine powder a; Put the coarse powder into the multi-functional extraction tank to extract twice, add 5-10 times the amount of water for decoction for 1-2 hours for the first time, add 4-8 times the amount of water for 1-2 hours for decoction for the second time, combine and decoct twice liquid, filtered to obtain the filtrate, heated and concentrated to a paste, dried in an oven at 80°C, cooled, ground into fine powder b, mixed with fine powder a and fine powder b, and packed into the capsule shell to obtain capsules.

The present invention provides a kind of preparation method of the Chinese medicine composition that is used for the treatment of knee osteoarthritis again, the dosage form of described Chinese medicine composition is a tablet, and described preparation method comprises the following steps:

a. Weigh Angelica sinensis, Sangjisheng and Chuanxiong according to the ratio of parts by weight, put them into 10 times the amount of 75% ethanol, heat and reflux for extraction twice, each time for 1-2 hours, extract active ingredients, and combine the two extracts Stand still to obtain extract 1;

b. Weigh the other raw medicinal materials except angelica sinensis, mulberry and chuanxiong according to the ratio of parts by weight, put them into 10 times the amount of water, heat and reflux and extract 3 times, each time for 30 minutes to 1 hour, combine the 3 extracts and static place, to obtain extract 2;

c. Combine extract 1 and extract 2, reclaim ethanol under reduced pressure and concentrate until the concentration of the medicinal solution is 0.5g crude drug/mL. After suction filtration, the relative density of the filtrate is 1.08 when the temperature is 20°C; The 10L macroporous adsorption resin column was eluted twice, first eluted with deionized water or distilled water 10 times the volume of the resin column, and then eluted with 95% ethanol 5 times the volume of the resin column, collected the ethanol eluate, and removed the solvent , to obtain raw materials, add starch or dextrin and press into tablets to obtain tablets.

The dosage forms of the traditional Chinese medicine composition are: tablets, sugar-coated tablets, film-coated tablets, enteric-coated tablets, capsules, hard capsules, soft capsules, oral liquids, buccal preparations, granules, granules, Pellets, powders, elixirs, solutions, injections, suppositories, plasters, syrups, powders, enemas, or patches.

the

The traditional Chinese medicine composition of the present invention has the advantages of traditional Chinese medicine treatment of knee osteoarthritis, mainly tonifying kidney and strengthening bones, dredging collaterals to relieve pain, promoting blood circulation and removing blood stasis, expelling wind and cold, etc.; New drugs that are easy to make and inexpensive. The invention adopts traditional Chinese medicinal materials with different medicinal properties, carries out scientific compatibility, can achieve an ideal therapeutic effect, is safe, has little toxic and side effects, is simple to prepare, can directly reach the lesion, has short healing time, and is not easy to relapse after being cured.

the

Detailed ways

Osteoarthritis is more common in middle-aged and elderly people, and is characterized by degeneration or destruction of knee articular cartilage, subchondral bone sclerosis, and osteophyte formation at the joint margin. Patients mainly present with knee joint pain, locking, dysfunction, and severe cases may also be accompanied by joint swelling, peripheral edema, and muscle atrophy. "Su Wen·Bi Lun": "The wind, cold and dampness are mixed together, and they form numbness." Said bone numbness." "Zhang's Medical General Knee Pain": "The knee is the viscera of the tendon, and the knee pain is all due to liver and kidney deficiency, and the deficiency is caused by wind, cold and dampness." All have clarified the traditional Chinese medicine etiology of this disease. machine. "The pathogenesis is long-term chronic aging, deficiency of qi and blood, and deficiency of liver and kidney; combined with wind-cold-damp evil taking advantage of deficiency to attack, stagnation of meridians, stagnation of qi and blood, and stagnation of qi and blood for a long time; Xi, long-term bone numbness.

External application of traditional Chinese medicine is one of the most commonly used external treatments of traditional Chinese medicine in clinical practice. "Yao" and the medical methods contained in Li Shizhen's "Compendium of Materia Medica" in the Ming Dynasty all involve external application of traditional Chinese medicine. Since the meridian has the function of internal viscera, external collaterals and limbs, communicating the external and internal, and running through the upper and lower parts, it can not only treat local lesions, but also achieve the purpose of treating systemic diseases through external application. Drugs pass through) the stimulation of local acupoints, penetrate through the skin, stimulate the qi of the meridians, promote the circulation of qi and blood in the viscera, and play a therapeutic role; the skin is thin, and the nerves and blood vessels are relatively rich, so the umbilicus has strong and rapid absorption It has good sensory and conduction functions, and when it is treated with appropriate drugs on the umbilicus, it can stimulate the local nerve endings, improve the physiological activities and pathological changes of viscera and tissues, and enhance the body's immunity and disease resistance. External application of traditional Chinese medicine integrates heat therapy, drug therapy, and moxibustion, which can strengthen the spleen and stop diarrhea, and avoid the inconvenience and pain caused by oral administration and injection. The first-pass effect of the liver and the interference and degradation of gastrointestinal factors reduce individual differences, quick onset, strong efficacy, no trauma, no pain, and easy to use.

In the prescription, Angelica has the function of nourishing blood and promoting blood circulation, and Chuanxiong promotes blood circulation. Notopterygium, Duhuo, and Fangfeng meridians dispel wind and diuresis to reduce swelling; safflower leads meridians through Achyranthes bidentata to remove blood stasis in the knees; Aconite, scorpion venom, curculigo, Morinda officinalis, salvia miltiorrhiza and safflower and other medicinal materials. Rehmannia glutinosa, Drynaria rhizome, Achyranthes bidentata, psoraleae, etc. can nourish the liver and kidney, strengthen tendons and bones; spaghetti vine and leech can promote blood circulation and break blood stasis; rehmannia glutinosa can enhance the patient's immunity and strengthen the grain. The activity of glutathione peroxidase, anti-blood coagulation, reducing lipid peroxidation, can effectively improve the symptoms of yin deficiency; the prescription uses aconite, which has anti-inflammatory, central and peripheral analgesia, and stimulates cells to secrete interleukin- 2. Enhance and regulate the immune function of the body; Danshen used in the prescription can enhance the immunity of the body, has the effects of lowering blood fat, anti-atherosclerosis, and improving microcirculation; Corydalis used in the prescription has the effects of analgesia, sedation and hypnosis; The prescription uses curculigo, which has the functions of anti-inflammation, promoting the proliferation of macrophages and phagocytosis; the prescription uses Morinda officinalis, which has the functions of anti-inflammation and enhancing anti-fatigue ability; The effect of dredging collaterals. The combination of various medicines has the effects of nourishing kidney yang, nourishing liver and kidney, promoting blood circulation and removing blood stasis, warming extremities, qi and water dampness, etc. Rhubarb and Panax notoginseng promote blood circulation and cool blood. Agrimony invigorates blood and cools blood. Sangjisheng, Gentiana, Sangzhi, etc. have the effect of promoting blood circulation and expelling wind. Guizhi Tongyang Wenjing. Hematoxylin spp., Luniancao, cuttings and cuttings, Lishiteng, and Haifengteng have the functions of dispelling wind and dredging collaterals.

Angelica, the product is the dry root of Umbelliferae Angelica sinensis. Excavate in late autumn, remove fibrous roots and silt, and after the water evaporates slightly, bundle them into small handles, put them in a shed, and slowly smoke them to dry with fireworks. The root of Angelica sinensis is slightly cylindrical, and the upper end of the root is called "guitou", and the main root is called "guishen" or "inch body". The root is called "gui tail" or "gui leg", and the whole is called "quangui". Whole angelica can not only nourish blood, but also activate blood, collectively referred to as harmony blood; Return liver; Heart; Spleen channel. Blood-tonifying medicine; menstruation-regulating medicine; analgesic medicine. Enriching blood; promoting blood circulation; regulating menstruation and relieving pain; moistening dryness and smoothing intestines. Various syndromes of blood deficiency; irregular menstruation; amenorrhea; dysmenorrhea; lumps and lumps; metrorrhagia; abdominal pain due to deficiency and cold; flaccid numbness; numbness of the skin; dryness of the intestine and difficulty in defecation; heavy dysentery after dysentery; carbuncle sores; injuries from falls.

Sangjishen nourishes liver and kidney; strengthens muscles and bones; dispels rheumatism; relieves miscarriage. Mainly soreness of the waist and knees; flaccidity of muscles and bones; partial dryness of limbs; rheumatic arthralgia; headache and dizziness; restless fetal movement, metrorrhagia and bleeding. For rheumatic arthralgia, soreness of the waist and knees, weakness of muscles and bones, metrorrhagia, bleeding during pregnancy, fetal movement; hypertension. ① "The Classic": Mainly lumbago, strong back in children, carbuncle, anti-pregnancy, skin filling, firm hair, teeth, long beard and eyebrows. ② "Bie Lu": main gold sores, Qubi, women's collapse, insufficient internal injuries, postpartum residual diseases, and breast milk. ③ "On the Properties of Medicine": It can make the fetus firm, and it can prevent bleeding during pregnancy. ④ "Nihuazi Materia Medica": Helps muscles and bones, benefits blood vessels ⑤ "Southern Yunnan Materia Medica": For those who grow locust trees, it is mainly used to treat blood in the large intestine, intestinal wind with blood, and hemorrhoids. Those who give birth to mulberry trees can treat pain in the muscles and bones, dislocation of tendons and collaterals, and arthralgia due to wind-cold-dampness. Those who give birth to Zanthoxylum bungeanum can treat coldness in the spleen and stomach, vomiting, nausea and stomach upset; ⑥ "Materia Medica Mengqi": loose sores, chasing rheumatism, but strong back and low back pain. ⑦ "Preparation of Herbal Medicine": heat dissipation, nourishing, chasing wind. Nourish blood and dissipate heat, make tea drink, relax muscles and activate collaterals. 8. "Jade catalpa medicine solution": control dysentery.

Gentiana chinensis, used for arthralgia due to rheumatism, spasm of tendons, aching joints, hot flashes in the afternoon, and malnutrition fever in children. 1. "Compendium": "Gentati chinensis, paralysis of hands and feet, jaundice, polydipsia must be taken, whichever is used to remove dampness and heat from Yangming. If there is dampness in Yangming, the body will be sore and hot, and if there is heat, it will cause hot flashes and bone steaming every day. "2. "Compendium of Materia Medica": "Gentica chinensis, bitterness can be relieved, pungent can be dispersed, and slight temperature can be beneficial, so it is mainly cold and heat evil, cold and damp wind numbness, joint pain, water, and urination. It has the function of dispelling wind and dampness, so "Bie Lu" "Treatment of wind without question for a long time, and the body's convulsions. It can dry dampness and heat stagnation, so "Rihuazi" treats bone steam and malnutrition; Zhen Quan treats alcoholic jaundice and detoxification; Insufficiency, intestinal wind and blood, nourishing blood and tendons; good ancient heat, benefiting courage. Salty is used for its dehumidification and stagnation, and the effect of clearing the stomach." 3. "Materia Medica Syndrome": "Gentica chinensis is good at nourishing blood, so it can reduce fever and relax tendons. To treat wind, first treat blood, and blood circulates wind to extinguish itself, so the treatment of wind will last for a long time. It enters the stomach to dispel dampness and heat, so it is convenient and jaundice heals also."

Rhizoma Chuanxiong, blood circulation promoting and blood stasis dispelling; Textual research: From "Tang Ye Materia Medica" Indications: The first choice for treating headaches. Irregular menstruation; amenorrhea dysmenorrhea; postpartum stasis and pain; abdominal mass; chest and hypochondrium pain; headache and dizziness; anemofrigid-damp arthralgia; bruises; carbuncle sores. "The Classic": main apoplexy into the brain headache, cold arthralgia, spasms emergency, metal wounds, women with blood closed and childless. "Bie Lu": In addition to the cold movement in the brain, the wind coming and going on the face, tears coming out of the eyes, excessive tears and saliva, sudden drunkenness, all kinds of cold air, pain in the heart and abdomen, evil in the middle, acute swelling and pain in the chest, wind pain in the hypochondriac, warm Inner cold. Tao Hongjing: Those with bleeding from the root of the tooth have a lot of bleeding. "On the Properties of Medicine": Treat weakness of the waist and feet, hemiplegia, prolapse of the main body clothes, and cold pain in the abdomen. "Rihuazi Materia Medica": cure all wind, all qi, all strains, all blood, nourish five fatigue, strengthen muscles and bones, regulate all channels, break old blood, nourish new blood, grow flesh, nasal flood, vomiting blood and drowning , hemorrhoids, fistula, cerebral abscess, scrofula, galls, sores and scabies, and drainage of pus and blood stasis. "Medical Genesis": Enrich blood, treat blood deficiency and headache. Wang Haogu: search liver qi, nourish liver blood, moisten liver dryness, nourish wind deficiency. "Compendium": dry dampness, stop diarrhea and dysentery, promote qi and relieve depression. Rhizoma Xiongzi is also a medicine for qi in the blood. If the liver is bitter and urgent, it should be supplemented with pungent, so it is suitable for those with blood deficiency; "Zuo Zhuan" says that wheat koji and juqiong can prevent dampness and treat abdominal diseases of river fish. To treat damp diarrhea, every time you add two flavors, it should be like a ring. If the bloody dysentery has passed and the pain persists, it is due to Yin deficiency and Qi stagnation, and the medicine is supplemented with Xiongxiong, and the Qi and blood can be adjusted, and the disease will stop immediately. "Materia Medica Yanyi": Xiongzi is the most used by people today, and the head and face wind cannot be missed, but it must be supplemented by other medicines.

Notopterygium, pungent in taste; bitter; warm in nature. ① "Medicine Properties": bitter and pungent, non-toxic. ② "Medical Qiyuan": "Secrets of Indications" cloud: warm in nature, pungent in taste. ③ "Decoction Materia Medica": the air is slightly warm, the taste is bitter and sweet, flat. Enter bladder, kidney channel. ① "Pearl Sac": Bladder Meridian of Foot Taiyang. Hand Taiyang Small Intestine ② "Decoction Materia Medica": Foot Taiyang, Jueyin Meridians. ③ "Materia Medica Mengguan": hand, foot Taiyang, foot Shaoyin, Jueyin meridian. Expelling exterior cold; expelling rheumatism; sharpening joints; relieving pain. Main exogenous wind-cold; headache without sweating; mimeograph cold-damp arthralgia; Fengshui edema; sore swollen toxin. For impotence and nocturnal emission, enuresis and frequent urination, cold pain in the waist and knees, asthma due to kidney deficiency, diarrhea at dawn; external use for treating vitiligo and alopecia areata. Relieve the exterior and dispel cold, expelling wind and dampness, relieving pain.

Live alone, expelling wind and dampness; dispelling cold and relieving pain. For anemofrigid-damp arthralgia; waist and knee pain; Shaoyin Fufeng headache, headache and toothache. 1. Anemofrigid-damp arthralgia. This product is pungent, bitter and dry, fragrant and warm, and its merits are good at eradicating rheumatism and relieving arthralgia. Enters the kidney meridian, is good in nature and descends, and is advisable especially for those with pain in the lower part of the waist, knees, and leg and foot joints. Treat wind-cold-damp arthralgia caused by wind-cold-damp evil, pain in muscles, lower back, and hands and feet. It is often used with Angelica, Atractylodes macrocephala, and Achyranthes bidentata, such as Duhuo Decoction ("Huoyou Xinshu"); if it is compatible with Sangjisheng, Eucommia, and Ginseng, etc. , can cure arthralgia syndrome with long-term positive deficiency, soreness of the waist and knees, and poor joint flexion and extension, such as Duhuo Jisheng Decoction ("Qianjin Fang"). 2. Syndrome of wind-cold and dampness. This product is pungent and warm, relieves bitterness and dryness, can disperse wind, cold and dampness and relieve the surface, and treat headaches caused by exogenous wind, cold and dampness, and the whole body is full of pain. On Distinguishing Confusion from Internal and External Injuries"). 3. Shaoyin headache. This product is good at entering the kidney meridian and searching for the wind. It is compatible with Asarum and Chuanxiong.

Guizhi, pungent; sweet; warm in nature. ① "Medical Qiyuan": Qi heat, spicy and sweet. ② "Hen Jing Feng Yuan": pungent, sweet, slightly warm, non-toxic. Enter bladder, heart, lung meridian. ① "Decoction Materia Medica": Enter the Taiyang Meridian. ② "Lei Gong Pao Medicinal Properties Solution": enters the lung meridian. ③ "Drug Chemicals": enter the liver, kidney, bladder three warps. ④ "Materia Medica Seeking Truth": enters the surface of the muscle, and also enters the heart and liver. Indications: dispelling cold and relieving the exterior; warming and dredging the meridians; dredging yang and transforming qi. Mainly wind-cold exterior syndrome; cold-damp arthralgia; extreme coldness of limbs; amenorrhea abdominal pain; lumps in the abdomen; chest obstruction; For anemofrigid cold, epigastric cold pain, amenorrhea due to cold in blood, arthralgia, phlegm retention, edema, palpitation, rushing to the dolphin. Gong sweating relieves muscles, warms the meridians, helps yang transform qi, dispels cold and relieves pain.

Olibanum, regulates qi and activates blood, relieves pain, chases poison. Control qi and blood stagnation, trusted subordinate's pain, carbuncle sore swelling, bruises, dysmenorrhea, postpartum blood stasis and tingling pain. ① "Bie Lu": treat wind, water, poison and swelling, remove bad breath. Treat rheumatoid rash pruritic poison. ② "Supplements to Materia Medica": treat deafness, apoplexy, and women's blood energy, can make wine, regulate wind-coldness, stop diarrhea in the large intestine, and treat various sores to make internal disappearance. ③ "Nihuazi Materia Medica": stop cholera, heartache. The decoction relieves pain and grows flesh. ④ "Syndrome Materia Medica": cure insomnia. ⑤ "Pearl Sac": calm the pain of various meridians. 6. "Compendium": eliminate all poisons of carbuncle and gangrene, protect the heart by tuoli, promote blood circulation and relieve pain, stretch tendons, and control women's dystocia and injuries. ⑦ "Materia Medica Congxin": control insanity, stop diarrhea. ⑧ "Essential Drugs and Prescriptions": For those with persistent abdominal pain, adding frankincense will have no effect.

Woody fragrance, promoting qi and relieving pain; regulating the middle and leading to stagnation. The main symptoms are satisfied with abdominal distention; abdominal distension and pain; vomiting and diarrhea; severe after dysentery. For distending pain in the chest and abdominal cavity, heavy diarrhea after diarrhea, indigestion, and lack of appetite 1. Spleen-stomach stagnation of abdominal distension or pain, belching, nausea and vomiting. 2. Chest tightness, abdominal distension, loss of appetite and loose stool caused by dampness and turbidity. 3. Cough and asthma caused by phlegm damp blocking the lung. 4. Evil Qi, ward off poison, epidemic disease, warm ghosts, strengthen will, and master dew. Take it for a long time without dreaming or sleeping. ("The Classic") 5. Disinfection, killing ghost essence, warming malaria and gu poison, insufficient qi, cold in the muscles, and the essence of medicine. ("Bie Lu") Mori, enters the liver meridian. ① "Departing Materia Medica": start with the Taiyin Meridian. ② "Materia Medica Zaixin": Enter the lung and kidney meridians. ③ "Summary of Materia Medica": start, foot Taiyin meridian. Dispelling rheumatism; dredging channels and collaterals; row water vapor. Main rheumatic arthralgia; stroke hemiplegia; edema beriberi; body wind itching. For shoulder, arm, joint pain and numbness. ① "Ben Cao Tu Jing": Treating wind, itching and dryness all over the body, beriberi, spasm of limbs, upper air, dizziness, lung qi cough, digestion; diuresis, and dry mouth. ② "Materia Medica Mengqi": It can benefit asthma, cough and adverse qi, and eliminate swelling and poisonous carbuncle. ③ "Materia Medica Huiyan": go wind-qi contraction pain. ④ "Compendium of Materia Medica": sharpening joints, nourishing body fluid, promoting water flow and dispelling wind. ⑤ "Jade catalpa medicine solution": cure apoplexy and cough. 6. "Materia Medica Zaixin": invigorating lung qi, drying dampness, nourishing kidney water, stimulating menstrual flow, relieving cough and restlessness, reducing swelling and relieving pain. ⑦ "Lingnan Herbal Collection": remove joint wind disease, and treat elderly crane knee wind. ⑧ "Modern Practical Chinese Medicine": Twigs and leaves are boiled ointment and taken to treat high blood pressure and numbness of hands and feet.

Agrimony, astringent to stop bleeding, stop dysentery, kill parasites. Widely used in various bleeding syndromes, such as: hematemesis, hematuria, hematochezia, metrorrhagia, hemoptysis, epistaxis, red and white dysentery, fatigue due to fatigue, carbuncle, bruises, traumatic bleeding, etc. ① "Luxianyan Materia Medica": "Leaf, treat sores and ringworm." ② "Southern Yunnan Materia Medica": "Treat women with red and white discharge, cold face and abdominal pain, and red and white bloody dysentery for a long time." ③ "Sheng "Herbal Preparations": "Treatment of bruises, hemostasis, and dispelling sores." ④ "Baicao Jing": "Exerting Qi and blood circulation, treating all kinds of diseases, dispelling fullness; bruises, hematemesis, metrorrhagia, dysentery, intestinal wind and blood "⑤ "Plant Name Map Test": "Treatment of wind, phlegm and low back pain." ⑥ "Pseudo-medicine article identification": "Treatment of scrofula." Function. It is suitable for lung disease hemoptysis, intestinal bleeding, gastric ulcer bleeding, dental bleeding, hemorrhoids, liver abscess and other diseases."

Eucommia, Eucommia is warm in nature and sweet in taste. It has the effects of nourishing the liver and kidney, strengthening the waist and knees, strengthening the bones and muscles, and preventing miscarriage. Eucommia can regulate the immune system, endocrine system, central nervous system, circulatory system and urinary system to varying degrees. Eucommia can stimulate the pituitary-adrenal cortex system and enhance the function of the adrenal cortex. Modern studies have also found that Eucommia has the same immune-promoting function as Codonopsis and Astragalus. All of these have confirmed the ancient Chinese statement about Eucommia ulmoides that "long-term use can lighten the body and resist aging". Invigorate liver and kidney, strengthen muscles and bones, and prevent miscarriage. Treat waist and spine pain, flaccidity and weakness of feet and knees, urination, vaginal dampness and itching, fetal leakage, restless fetal movement, and high blood pressure. "Jade Catalpa Medicine Solution": "Tonify the liver and kidney, nourish the bones and muscles, and remove dampness in the joints. Treat soreness in the waist and knees, and spasms of the legs and feet." , Anti-abortion. Used for liver and kidney deficiency, sore waist and knees, weakness of muscles and bones, dizziness, bleeding during pregnancy, restless fetus.” Eucommia is a valuable nourishing medicinal material, and its active ingredients contain a large number of known active medicinal ingredients. It also contains a variety of nutrients, which are the important material basis for the health care of Eucommia ulmoides.

Rehmannia glutinosa, nourishes blood and nourishes yin, replenishes essence and marrow. Application1. Various evidences of blood deficiency. This product is sweet, warm and moist, nourishes yin and replenishes essence to produce blood, and is an essential medicine for nourishing blood and tonifying deficiency. Often used together with Angelica, Radix Paeoniae Alba, and Chuanxiong to treat blood deficiency and chlorosis, dizziness, palpitations, insomnia, irregular menstruation, metrorrhagia, etc., such as Siwu Decoction); It can be used together with tranquilizers; if metrorrhagia and bleeding causes blood deficiency and coldness in blood, and cold pain in the lower abdomen, it can be used together with donkey-hide gelatin, mugwort leaves, etc. 2. All syndromes of liver and kidney yin deficiency. This quality nourishes the kidneys, is good at nourishing kidney yin, replenishes essence and marrow, and is an essential medicine for invigorating kidney yin. The ancients called it "replenishing the five internal organs and true yin" and "replenishing true water". It is often used with yam and cornus to treat liver and kidney yin deficiency, soreness of the waist and knees, nocturnal emission, night sweats, tinnitus, deafness and thirst, etc. It can nourish the liver and kidney, and benefit the essence, such as Liuwei Dihuang Wan; , tortoise shell, etc. are used to treat yin deficiency and bone steaming hot flashes, such as Dabuyin pills ("Danxi Xinfa"). This product benefits essence and blood, black beard and hair, and is often compatible with Polygonum multiflorum, Achyranthes bidentata, Dodder, etc., to treat deficiency of essence and blood and premature graying of beard and hair, such as Qibao Meiran Dan ("Medical Prescription Collection"); this product nourishes essence and marrow, strengthens tendons Bone can also be combined with tortoise shell, Cynomorium, dog spine, etc., to treat liver and kidney deficiency, five late and five soft, such as Huqian Pills ("Medical Prescription Collection"). In addition, Rehmannia glutinosa can stop bleeding, and can be used for blood deficiency and bleeding syndromes such as metrorrhagia and metrorrhagia.

Corydalis Corydalis, promoting blood circulation; dispelling blood stasis; regulating qi; relieving pain. Main confidant waist and knee pain; irregular menstruation; lump in the abdomen; metrorrhagia; postpartum haemorrhage; lochia endlessly; bruises. It is used for chest pain, epigastric pain, amenorrhea dysmenorrhea, postpartum stasis, tumbling and swelling. 1. Analgesic effect: Corydalis powder has analgesic effect, and its analgesic potency is about 1/100 of that of opium; Corydalis total alkaloids, corydalis A, B, ugine, and decanol all have analgesic effects, and B is the stronger ． Alcoholic extracts and powders are the most effective in various dosage forms. 2. Sedative, stable and hypnotic effects: Tetrahydropalmatine has certain sedative and stable effects, and its L-form is a new type of central nervous system inhibitor. It has obvious hypnotic effects on rabbits, dogs and monkeys in larger doses. 3. Effects on the digestive system: DHCR has significant anti-gastric ulcer effects in rats.

Tibetan clove, slightly bitter; astringent; flat. Functions and indications: strengthening tendons and bones; promoting dampness and reducing swelling. Kidney deficiency lumbago; dystrophic edema; eczema; bruises.

Caulis Spatholobus, promotes blood circulation and relaxes tendons; nourishes blood and regulates menstruation. Main numbness of hands and feet; limb paralysis; rheumatic arthralgia; women have irregular menstruation; dysmenorrhea; For irregular menstruation, blood deficiency and chlorosis, numbness and paralysis, rheumatic arthralgia. With Motherwort, it can promote blood circulation and remove blood stasis, regulate menstruation and relieve pain; with Atractylodes Rhizome, it can regulate qi and eliminate dampness, eliminate filth and turbidity; 1. Irregular menstruation, dysmenorrhea, amenorrhea. This product is bitter but not dry, warm but not strong, promotes blood circulation and dissipates blood stasis, regulates menstruation and relieves pain. To treat irregular menstruation, dysmenorrhea, and amenorrhea caused by blood stasis, it can be used in combination with angelica, chuanxiong, and Cyperus cyperi; 2. Rheumatic arthralgia, numbness in hands and feet, limb paralysis and blood deficiency and chlorosis. This product promotes blood circulation and nourishes blood, relaxes muscles and tendons and activates collaterals. It is a commonly used medicine for treating meridian blockage and disharmony of collaterals. Such as treating rheumatic arthralgia, numbness of limbs, it can be compatible with anti-rheumatic medicines, such as Duhuo, Clematis, Sangjisheng, etc. Dragon and other medicines; to treat numbness of limbs and chlorosis due to blood deficiency without nourishing tendons, it is mostly used with astragalus, angelica and other medicines for nourishing qi and blood. 3. Treatment of radiation leukopenia: used together with other medicines for nourishing qi and blood.

Achyranthes bidentata, 1. "Southern Yunnan Materia Medica": control furuncle, carbuncle, and apply to the affected part. Can also abort. Simmer it with pork to improve eyesight. 2. "Experiential Identification Method of Form and Property of Traditional Chinese Medicine": It has the effects of diuresis, strengthening essence and stimulating menstruation. It can relax tendons and activate blood circulation, and treat waist and knee pain. 3. "Herbal Classic": main cold-damp flaccidity, spasm of limbs, knee pain unyielding, expulsion of vigor, injury from heat and rotten fire, abortion. 4. "Bie Lu": Healing the lack of qi in the wound, disappearing the male kidney yin, the elderly lost drowning, nourishing the middle and continuing the continuation, filling the bone marrow, eliminating the pain in the brain and back pain, women with menstrual flow, blood knots, benefiting essence, Promoting yin qi, stopping whitishness. 5. "Properties of Medicine": treat impotence, tonify kidney and replenish essence, expel evil blood stagnation, and help the twelve meridians. 6. "Nihuazi Materia Medica": cure weakness of the waist and knees, break the crux of the problem, drain pus and relieve pain, postpartum abdominal pain and blood circulation, abortion, and strengthen yang. 7. "Materia Medica Yanyi": soaked in wine with Cistanche deserticola and taken to benefit the kidney; bamboo and wood are pierced into the meat, smashed to a pulp, and then come out. Traditional Chinese medicine believes that its nature and taste are bitter, sweet and sour, and it has the effects of promoting blood circulation, nourishing liver and kidney, strengthening bones and muscles, diuresis and treating stranguria, and drawing blood (fire) downward. Diarrhea, postpartum abdominal pain and other gynecological diseases, bruises, waist and knee pain due to kidney deficiency, weakness of lower limbs, hematuria, dysuria, astringent pain in the urethra, headache, dizziness, hematemesis, and epistaxis caused by fiery upper inflammation. 1. Huai Achyranthes Knee function nourishes the liver and kidney, strengthens the waist and knees: it is used for the weakness of muscles and bones, pain in the waist and knees caused by liver and kidney deficiency. 2. Chuan Achyranthes bidentata is good at promoting blood circulation and promoting menstrual flow, and dispelling rheumatism: it is used for blood stasis, amenorrhea and rheumatic pain. This product is good at descending, and it is specially used to treat upper inflammation and upper part bleeding, so it is often used for conjunctival congestion, swollen throat, vomiting blood, and epistaxis.

Three edges, bitter in taste, flat in nature. Dispelling blood, promoting qi circulation, eliminating stagnation and relieving pain. Clinical application: suitable for a variety of tumors, such as ovarian cancer, cervical cancer, liver cancer, etc. It is often used in combination with Cyperus cyperi, curcuma, comfrey root, wood steamed bread, etc. to treat ovarian cancer and cervical cancer with Qi and blood accumulation and blood stasis. Hedyotis diffusa, Dabupi, Poria, Curcuma, etc. are often used in combination to treat liver cancer with stagnation of qi, blood stasis, and heat-toxin accumulation. In addition, this product is also suitable for blood stasis and qi stagnation, abdominal agglomeration, hepatosplenomegaly, amenorrhea abdominal pain, food accumulation pain, etc.

Curcuma, 1) breaking blood, promoting qi and relieving pain: the effect of this product is similar to that of Sanleng, but it has a greater warming and tonifying force, and can treat abdominal pain, abdominal mass and accumulation due to blood stagnation and amenorrhea. 2) Accumulation and dissipating stagnation: This product can promote qi, eliminate stagnation and relieve pain, and is used for stagnation in diet, fullness and pain in the chest and abdomen. 3) Dispelling blood and removing blood stasis, women with amenorrhea, or lumps in the abdomen caused by phlegm dampness and blood stasis. 4) Promoting qi and relieving pain: suitable for symptoms of eating disorders, abdominal fullness and pain. Appropriate compatibility can be used for deficiency syndrome and excess syndrome. Multiple use. 5) Precautions: Pregnant women should not use it

Aconite, recovering yang and resuscitating adversity, nourishing fire and supporting yang, dispelling cold and relieving pain. "The No. 1 medicine for recovering yang and rescuing adverse events" is used for Yin excess and yang suppression, profuse sweating and yang loss, vomiting and diarrhea, cold extremities and weak pulse, cold pain in trusted subordinates, cold dysentery, beriberi edema, wind-cold-damp arthralgia, impotence, uterine cold, and deficiency Cold vomiting and diarrhea, Yin-cold edema, Yang-deficiency exogenous pathogenesis, Yin gangrene and sores, and all chronic cold diseases. Moreover, aconite has an excitatory effect on the pituitary gland-adrenal cortex system, and can also excite the vagus nerve to strengthen the heart. Aconite should not be eaten with fermented soy sauce, mainly because fermented soy sauce has a bitter or salty taste. Aconite is a medicine with great pungentness and great heat, and it is a medicine for warming the interior and restoring yang. The properties of the two medicines are opposite, and taking them at the same time will reduce the efficacy of the medicine.

Rhizoma Curculigo, nourishes kidney yang, strengthens muscles and bones, dispels cold and dampness. Treatment of impotence and cold essence, urinary incontinence, metrorrhagia, confidant cold pain, cold arthralgia of waist and feet, carbuncle, scrofula, yang deficiency and cold diarrhea. Impotence and essence-cold, wind-cold waist and knees, muscle and bone flaccidity and numbness embolism. Among the ancient prescriptions, there is Xianmao Pill, which can strengthen the muscles and bones, benefit the spirit, improve eyesight, and blacken the beard and hair. ① "Haiyao Materia Medica": Main wind, warming the waist and feet, clearing the five internal organs, strengthening muscles and bones, and digesting food. Propagation and supplementation can treat the seven injuries of the husband, improve the eyes and ears, strengthen the tendons, fill the bone marrow, and benefit yang. ② "Nihuazi Materia Medica": cure all wind, tonify five labors and seven injuries, appetizing and lowering qi. ③ "Kaibao Materia Medica": the main confidants can't eat due to air-conditioning, the waist and feet can't walk due to wind-cold convulsions, the husband is exhausted, and the elderly are drowning. ④ "Southern Yunnan Materia Medica": control women's red metrorrhagia, attack carbuncle, and drain pus. ⑤ "Preparation of Raw Herbal Medicine": Tonify the kidney, relieve pain, control white turbidity, regulate phlegm fire, and cook meat. Steamed ten times and dried nine times, stored with sugar, served with tea in the morning, it can strengthen the spirit and make the beard and hair black. ⑥ "Jade catalpa medicine solution": control skin wind leprosy.

Morinda officinalis, impotence due to kidney deficiency, seminal emission, premature ejaculation, cold pain in the lower abdomen, incontinence of urination, infertility due to uterine cold, arthralgia due to wind-cold-dampness, soreness of the waist and knees, rheumatic extremity qi. Zan Yudan's "Jingyue Quanshu": invigorating the kidney and strengthening yang. Yulin Pill "Experience Prescription": male infertility, female infertility. Cistanche tonifying deficiency and replenishing qi prescription "Preparation for Emergencies": Deficiency of the five viscera; Jingang Pill "Zhang's Yitong": Kidney deficiency and impotence.

Soap core, sweet; warm. Return lung; Heart; Large Intestine Channel. Function cures mainly: eliminating phlegm; Laxative; Diuretic; Desinsection. Mainly obstinate phlegm obstruction; large intestine wind secret; diarrhea; stranguria syndrome; scabies.

Salvia miltiorrhiza has the effects of activating blood and dispersing stasis, reducing swelling and stopping bleeding, reducing inflammation and pain, regulating menstruation and relieving pain, dilating coronary arteries, improving myocardial ischemia, lowering blood pressure, calming the mind, lowering blood sugar and antibacterial effects. Accumulation of lumps, tingling pain in the chest and abdomen, heat pain, sore swelling and pain, restlessness and insomnia; hepatosplenomegaly, angina pectoris and other diseases have a certain effect. In addition, modern medical experiments have proved that Salvia miltiorrhiza also has the functions of anti-platelet aggregation, reducing blood viscosity and regulating the internal and external coagulation system. It is a safe and reliable natural Chinese medicine for treating cardiovascular diseases. It is used for sternocostal and hypochondriac pain, rheumatic arthralgia, lumps in the abdomen, swelling and pain of sores, pain from falls, irregular menstruation, amenorrhea dysmenorrhea, postpartum stasis and pain, etc. It has good effects in treating sternocostal pain, lumps in the abdomen, irregular menstruation, and amenorrhea, and is often used in combination with Chuanxiong. In the treatment of chest and abdomen pain belonging to qi stagnation and blood stasis, it is often used together with medicines such as amomum and sandalwood. For febrile disease heat into camp blood, body rash, dizziness and irritability. It is often used together with fresh rehmannia glutinosa, buffalo horn, scrophulariaceae and other medicines. For palpitations, insomnia. It is often used together with medicines such as Suanzaoren and Baiziren.

Flos Carthami, warm in nature, pungent in taste, promotes blood circulation to stimulate menstrual flow, dissipates blood stasis and relieves pain. For amenorrhea, dysmenorrhea, lochia, lumps in the abdomen, bruises. The ancients often added a handful of safflower when the blood was in the body. Boil the gauze bag and soak your feet twice a day. It is suitable for all kinds of varicose veins, peripheral neuritis, poor blood circulation, numbness of legs and feet, or bruising. Irregular menstrual blood, postpartum abdominal pain, lump in the abdomen, traumatic bruising, swelling and pain, carbuncle swelling and pain embolism. From "Bencao Tujing": "Red and blue flowers, that is, safflowers. Today, they are everywhere. They are planted in people's gardens, and the cloth is placed on the ripe ground in winter. Seedlings grow in spring, and there are flowers in summer. They are thorny and thorny. The pistils come out of the sills, and the gardeners accept them to pick them up. The stalks are harvested, and they are all gone. The stalks are firm, white, as big as adzuki beans. The flowers are quickly dried to dye them red, and used as swallow fat. It is mainly used for postpartum blood diseases. For victory. In fact, it is the same. The leaves look like blue, so they have the name of blue." "Materia Medica Shugouyuan": "Red and blue flowers, nourishing blood, decocting, breaking blood and wine."

Rhubarb, attacking stagnant stagnation; clearing damp-heat; purging fire; cooling blood; removing blood stasis; detoxification. Indications: Excessive heat and constipation; hot knot in the chest; damp-heat diarrhea; jaundice; gonorrhea; edema and abdominal fullness; difficulty urinating; red eyes; sore throat; sore mouth and tongue; vomiting due to stomach heat; vomiting blood; Hematuria; blood accumulation; amenorrhea; postpartum stasis and abdominal pain; abdominal mass accumulation; bruises; pyretic carbuncle and ulcer; erysipelas; scald.

Radix Notoginseng and Radix Notoginseng have great effects. It is warm in nature and pungent in taste. It has the effects of dispelling stasis and hemostasis, reducing swelling and relieving pain. Tingling pain embolism. Moreover, the flavonoids in Tianqi can improve myocardial blood supply, increase blood vessel elasticity, and expand coronary arteries. Sitosterol and carotin can lower blood lipids. Regular consumption of Tian Qi can prevent and treat coronary heart disease and angina pectoris. Return Liver Channel; Stomach Channel; Heart Channel; Lung Channel; Large Intestine Channel. Function: stop bleeding; disperse blood; relieve pain. Contraindications: Dysmenorrhea and menstrual disorders caused by Qi and blood deficiency should not be used. It is manifested as dull pain in the lower abdomen during or after menstruation. Cure mainly: bruises and swelling, chest obstruction and colic, lump in the abdomen; blood stasis amenorrhea; dysmenorrhea; postpartum stasis and abdominal pain; sore carbuncle swelling and pain.

Sumac, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain. Such as women's amenorrhea due to stagnation of blood, dysmenorrhea, postpartum stasis and abdominal pain, postpartum blood dizziness, carbuncle, bruises, and tetanus. The heartwood is used as medicine, and it is a blood purifying agent, which has the effects of eliminating phlegm, relieving pain, promoting blood circulation, and dispersing wind. In recent years, Yunnan Institute of Botany has extracted a kind of hematoxylin from the heartwood of hematoxylin, which can be used for dyeing biofilms, and the effect is no less than that of imported Brazilian hematoxylin. The sapwood of this species is yellowish reddish, the heartwood is ochre-brown, the texture is inclined, the structure is fine, the material is hard, heavy, shiny, less cracked after drying, and it is used for joinery. 1. "Tang Materia Medica": Mainly breaks the blood, postpartum blood swelling and depression. 2. "Supplements to Materia Medica": Mainly for cholera vomiting and people's frequent vomiting, decoct it with water. Broken blood should be boiled with wine. 3. "Haiyao Materia Medica": It is mainly used for consumptive labor, blood addiction, qi stagnation; postpartum lochia uneasiness, abdominal pain; and meridian blockage, male and female strokes, and speechlessness. It is advisable to grind the fine powder of nipple fragrance into a square-inch dagger, decoct Su Fang in wine, remove the dregs, adjust the clothes, and spit out the bad things immediately. 4. "Nihuazi Materia Medica": treat women's qi and stomach pains, menstrual irregularities and childbirth labor. Evacuation of pus and relieving pain, eliminating carbuncle and swelling, swollen and blood stasis, women's aphonia, stasis of blood, red and white dysentery and acute pain afterward. 5. "Origin of Medicine": "Secrets of Indications" cloud, diverging external and internal atmosphere. Broken blood. 6. Li Guo: broken sores and dead blood, postpartum septicemia. 7. "Yi Lin Zhuan Yao": To invigorate the heart and dissipate blood stasis, remove wind-heat caused by blood components.

Deer Bites Grass can invigorate deficiency, nourish kidney, dispel wind and dampness, activate blood and regulate menstruation, tonify kidney and strengthen bones, relieve cough and stop bleeding. Indications: Lumbago due to kidney deficiency, rheumatic arthralgia, flaccidity of muscles and bones, chronic cough, hematemesis, epistaxis, metrorrhagia, traumatic bleeding. 1. "Southern Yunnan Materia Medica": "The nature is warm and flat, and the taste is pungent. It can treat the pain of muscles and bones, and the symptoms of phlegm." White wisps, slightly long like bok choy, and the roots are also purple." 3. "Chinese Medicine Plants": cure consumptive tuberculosis, relieve cough. 4. "Chongqing Herbal Medicine": Treat weak tuberculosis, cough, leucorrhea. 5. "Sichuan Commonly Used Chinese Herbal Medicine": expelling wind and dampness, stopping palpitations and night sweats. 6. "Shaanxi Chinese Herbal Medicine": invigorating the kidney and strengthening yang, regulating menstruation and promoting blood circulation, astringent and hemostasis.

Cutting live, antibacterial and anti-inflammatory, expelling wind and dampness, promoting blood circulation and relieving pain. Treat pneumonia, acute appendicitis, acute gastroenteritis, bacillary dysentery, rheumatic pain, bruises, and fractures. The medicinal parts are whole herb, pungent, bitter and flat in nature. It has the effects of antibacterial and anti-inflammatory, clearing away heat and detoxification, expelling wind and dampness, promoting blood circulation and relieving pain, promoting menstrual flow and setting bones, etc. Tumors, bruises, fractures, etc. In recent years, it has been used to treat pancreatic cancer, gastric cancer, rectal cancer, liver cancer, esophageal cancer, etc., with more significant effects. Cortex Teng, has the effects of expelling wind and removing dampness, dredging collaterals to relieve pain, clearing away heat and cooling blood, detoxifying and reducing swelling, and is mainly used for dispelling wind and dredging collaterals, cooling blood and reducing swelling. For rheumatism-heat arthralgia, spasm of tendons, soreness of waist and knees, sore throat, carbuncle, injury from falls. 1. "Compendium": Contrast stone, the smell is gentle, and its main function is wind-heat carbuncle of muscles, bones and joints, whitening and resistance to aging, that is, doctors who seldom know how to use it, how can it be ignored because it is close to cheap. Serve it as soaking ears in wine. 2. "Departing Materia Medica": Contrastite, combined with Shegan and Shanzhi, can cure poisonous gas attacking the throat. Combined with ginseng, Ling, and keel, it can cure white turbidity. 3. "Essential Medicines and Prescriptions": The merit of the collateral stone, which is specially used to relax the tendons and activate the collaterals. For patients with convulsions of tendons and arteries, who are not easy to stretch and bend, taking it will all be effective, and it should not be ignored. 4. "Materia Medica Justice": the smell of the stone, the "Ben Jing" is called bitter temperature, and the cover is based on the function of dredging the meridian and promoting blood circulation, so it is considered warm. However, the indications in the "Ben Jing" are purely fever, and it is not known as warm, so "Bie Lu" is changed to slightly cold, and "Yu Lan" quotes Li Dangzhi's statement, and thinks it is a severe cold. This thing is good at walking the meridians and reaching the limb joints. "The Classic" governs wind-heat dead muscles, and "Bie Lu" nourishes the kidneys, governs waist and hip pain, strengthens tendons, and sharpens joints, all of which have this meaning. It cures carbuncle, swollen mouthpiece, dry mouth and tongue burn, all of which have the functions of letting down the bitter cold. "Bie Lu" says that it can get rid of that gas, then it is in terms of evil heat. The word "evil spirit" in "Ben Jing" and "Bie Lu" is the most comprehensive. In fact, each has its own idea, and it is not a general term. However, the four characters "big shock enters the belly" are not very intelligible, and should be dubious. Congratulations, it is said to treat postpartum blood knots, which is based on the blockage of blood stasis and dew. It is also said to be a good medicine for clearing away heat and letting down the heart, which is mainly used for sores and poisons in the heart of Agkistrodon halys. It is also known as the sore wounded by the knife and ax, and if it is applied to make it heal, it will also be treated externally as the magic pill for promoting blood circulation. The hidden device is said to govern all winds, that is, "The Classic" controls wind-heat dead muscles, and "Bie Lu" sharpens the meaning of joints. Now it is used to relax the joints and activate the collaterals, and it is very effective for dispelling numbness and pain.

Caulis Caulis, dispelling wind-damp, dredging channels and collaterals, relieving numbness and pain. For anemofrigid-damp arthralgia, pain in extremities, spasms of tendons and arteries, and difficulty in flexion and extension. 1. "Materia Medica Zaixin": Promoting meridians, harmonizing blood vessels, widening the middle and regulating qi, removing dampness and wind, regulating waist and beriberi, treating hernia, and preventing miscarriage. 2. "Zhejiang Traditional Chinese Medicine Handbook": Xuanbi, dampness, dredging collaterals and relaxing tendons. Control leg knee flaccidity, arthralgia. 3. "Chinese Medicine Annals": "pungent, slightly warm." "Materia Medica Zaixin": "Enter the heart and kidney meridians." 4. "Do not record": the main gold sores. 5. "Kaibao Materia Medica": Main wind and blood, nourish aging, raise yang, strengthen waist and feet, remove numbness, turn white, chase cold air, and expel wind evil. It is also taken in boiled juice and soaked in wine. It is used in Dongyue. 6. "Ben Cao Tu Jing": controls low back pain. 7. "Southern Yunnan Materia Medica": Treating cold-damp arthralgia and tendons injury, expelling wind, pain in muscles and bones, facilitating urination and pain in the stem, early onset of hot stranguria, facilitating rapid urination. 8. "Compendium": boil the juice and take it to treat cough due to Shangqi.

the

Example 1 Patch

The embodiment of the present invention provides a traditional Chinese medicine composition for treating knee osteoarthritis, the dosage form is a patch, and its preparation method is as follows:

a. Weigh 1600g of Angelica, 1800g of Sangji, 1700g of Rhizoma Chuanxiong, 1500g of Qianghuo, 2900g of Duhuo, 1500g of Gentiana chinensis, 1500g of Guizhi, 1500g of Frankincense, 1500g of Muxiang, 1700g of Sangzhi, 1500g of Agrimony, 1500g of Eucommia, 1400g of Rehmannia glutinosa, Corydalis Corydalis 1400g, 1500g Tibetan clove, 1600g Caulis Spatholobus, 2100g Achyranthes bidentata, 1600g Sanleng, 1600g curcuma, 1500g aconite, 1800g curculigo, 1700g Morinda officinalis, 1200g soap core, 1500g salvia miltiorrhiza, 1700g safflower, 1500g rhubarb, notoginseng Add 1500g, 1500g sumac, 1600g cervus, 1400g skewer, 1400g genus genus, 1500g genus chinensis, add 10 times the amount of 85% ethanol, heat and reflux for 2 times, each time for 2 hours, and extract the solution statically place, to obtain extract 1, and the dregs for subsequent use;

b. add water to the dregs extracted by ethanol in step a, heat and reflux to extract twice, each time for 2 hours, combine the extracts and let stand to obtain extract 2;

c. Combine extract 1 and extract 2, pump them into a vacuum concentration tank, reduce the pressure to 0.06MPa, keep the temperature at 70°C, concentrate to an extract with a relative density of 1.20, and heat to 65°C. Paste, mixed with wine, vinegar and honey to get the patch.

the

Embodiment 2 capsules

The embodiment of the present invention provides a traditional Chinese medicine composition for treating knee osteoarthritis, the dosage form is capsule, and its preparation method comprises the following steps: weighing 1200g of Angelica sinensis, 2000g of Sangjisheng, 1200g of Chuanxiong, 1200g of Notopterygium, 4200g of Duhuo, Gentiana 1700g, Guizhi 1200g, Frankincense 1700g, Woody Fragrance 1900g, Morus twig 1400g, Agrimony 1100g, Eucommia 1000g, Rehmannia glutinosa 1000g, Corydalis 1800g, Tibetan clove 1200g, Milletah 1200g, Achyranthes bidentata 1500g, Trigonum 1200g, Curcuma zedoary 1200g, aconite 1000g, curculigo 1200g, Morinda officinalis 1200g, soap core 1500g, salvia miltiorrhiza 1000g, safflower 1200g, rhubarb 1000g, notoginseng 1000g, hematoxylin 1100g, deerbita 1200g, skewer live 1800g, safflower 1700g 1200g of Caulis Caulis, after being crushed into coarse powder, further pulverized, passed through a 100-120 mesh sieve, so that the amount of fine powder that can pass through the sieve reaches 30%, and the fine powder that passes through the sieve is collected to obtain fine powder a; Coarse powder passed through a 120-mesh sieve is put into a multi-functional extraction tank for extraction twice. For the first time, 8 times the amount of water is added to decoct for 2 hours, and for the second time, 7 times the amount of water is added to decoct for 2 hours. The two decoctions are combined and filtered to obtain The filtrate is heated and concentrated to a paste, put into an oven at 80°C, dried, cooled, ground into fine powder b, mixed with fine powder a and fine powder b, and packed into a capsule shell to obtain capsules.

the

Example 3 Tablet

The embodiment of the present invention provides a kind of traditional Chinese medicine composition for treating knee osteoarthritis, dosage form is tablet, and its preparation method comprises the following steps:

a. Weigh 2000g of Angelica sinensis, 1200g of Sangjisheng and 2200g of Rhizoma Chuanxiong, put into 10 times the amount of 75% ethanol, heat and reflux for extraction twice, each time for 1.5 hours, extract active ingredients, combine the two extracts and let stand to obtain Extract 1;

b. Weigh 1900g Notopterygium, 1000g Duhuo, 1100g Gentiana, 1900g Guizhi, 1200g Frankincense, 1000g Woody Fragrance, 2400g Mori Twig, 2000g Agrimony, 1500g Eucommia, 1200g Rehmannia glutinosa, 1200g Corydalis Corydalis, 1700g Tibetan Clove, and 1700g Miltonia Spatholobus , Achyranthes bidentata 1900g, trigonum 1800g, curcuma 1800g, aconite 1800g, curculigo 2200g, Morinda officinalis 2200g, soap core 1700g, salvia miltiorrhiza 1700g, safflower 1700g, rhubarb 1300g, notoginseng 1900g, sumac 1300g, deer grass 1600g 1, 1200g of skewers, 1100g of terrazzo vines, 1800g of sea wind vines, put into 10 times the amount of water, heat and reflux for extraction 3 times, each time for 40 minutes, combine the 3 extracts and let stand to obtain extract 2;

c. Combine extract 1 and extract 2, reclaim ethanol under reduced pressure and concentrate until the concentration of the medicinal solution is 0.5g crude drug/mL. After suction filtration, the relative density of the filtrate is 1.08 when the temperature is 20°C; The 10L macroporous adsorption resin column was eluted twice, first eluted with deionized water or distilled water 10 times the volume of the resin column, and then eluted with 95% ethanol 5 times the volume of the resin column, collected the ethanol eluate, and removed the solvent , to obtain raw materials, add starch or dextrin and press into tablets to obtain tablets. 0.3g per tablet.

the

Pharmacological and pharmacodynamic experiments:

1. Acute skin toxicity test for external use

Test method: according to the Ministry of Health "Hygienic Standards for Cosmetics" (2002) part two "acute percutaneous toxicity test" one-time limited test method, 20 SD rats, male and female, body weight 90g～180g, the present invention's embodiment 1 Obtained patch, percutaneous application of 5000mg/kg body weight dose, observed for 15 days, no obvious symptoms of poisoning, no death, no abnormality in animal gross anatomy, judging that this product belongs to the actual non-toxic level for acute percutaneous toxicity in rats .

2. Acute skin irritation test for external use

Test method: This product is based on Section 6.3 in the second part of "Skin Irritation/Corrosion Test" in the "Hygienic Standards for Cosmetics" (2002) of the Ministry of Health. 4 male Japanese white rabbits with a body weight of 2kg to 3kg are used in this example. Apply 0.5g of patch 1 directly on the skin on the left side of the animal (the other side is used as a control), adopt a closed test, apply for 4 hours, rinse the residual test substance with warm water after the test, and remove the test substance for 1 hour , 24h, 48h and 72h to observe the skin reaction of the animal test area and the control area respectively, and the highest integral mean value is "0", judging that the product is non-irritating to the animal skin.

3. Oral administration acute toxicity test

Forty NIH mice, SPF grade, half male and half male, weighing 16-20 g, were used for acute toxicity test. Mice are divided into two groups at random, every group of 20, i.e. control group and administration group, fasting 12 hours before experiment; The tablet prepared by the embodiment of the present invention 3 is dissolved in water, (concentration is 6.58g crude drug/ ml, the highest concentration) by gavage, the volume of gavage is 5ml/kg (that is, the single dose is 32.9 crude drug/kg), the control group is given the same amount of normal saline, twice a day, and the interval between administration is 6 hours, Continuously observe for 14 days after administration, and record the number of toxic reactions and deaths of the mice. The results of the experiment showed that compared with the control group, there was no significant difference in the mice after administration. After 14 days of continuous observation in the experiment, the general condition, diet, drinking water, and weight gain of the mice were all normal. Mice were orally gavaged with the tablet LD50 of the present invention>32.9 crude drug/kg, and the maximum daily dosage was 65.8 crude drug/kg/day. The clinical dosage of the traditional Chinese medicine of the present invention is 4.4g of crude drug/day/person, and the average dosage of the drug is 0.073g of crude drug/kg/day in terms of adult body weight of 60KG. In terms of body weight: the tolerated dose of the traditional Chinese medicine of the present invention is 901 times of the clinical dosage in mice (average body weight is 20 g). Therefore, the traditional Chinese medicine anesthetic drug of the present invention has low acute toxicity and is safe for clinical use.

4. Oral long-term toxicity test:

The capsule of the embodiment of the present invention 2 is used continuously for 12 weeks by 7.81, 18.34 and 40.11g crude drug/kg to mice (1.0ml/100g body weight, 2 times a day) and after drug withdrawal for 4 weeks, the results show that: the Chinese medicine of the present invention The preparation has no obvious effect on the hair, behavior, defecation, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of rats. After 1 week and 4 weeks after stopping the drug, there was no significant change in the organs of the rats. It shows that the traditional Chinese medicine preparation of the present invention has little toxicity to rats after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe.

the

clinical information

1. Materials and methods

1.1 General information: During the period from September 2011 to August 2012, a total of 360 patients with knee osteoarthritis were diagnosed and treated, including 178 males and 182 females, 34 patients aged 40-50, and a total of 51-60 years old. 92 cases, a total of 108 cases were 61-70 years old, and 126 cases were over 70 years old. Randomly divided into three groups, treatment group 1-3, 120 cases in each group. There was no statistically significant difference in age, sex, and severity of the three groups of patients, and they were treated in outpatient clinics according to the severity of the illness.

1.2 Diagnostic criteria:

Knee joint standards developed by the American College of Rheumatology (ACR): Knee pain and X-shape of the knee showing bone deflection, accompanied by any of the following:

a. Age ≥ 40 years old;

b. Stiffness of the affected knee <30min;

c. There is a bone friction sound.

1.3 Criteria for evaluating curative effect:

Clinical cure: Knee joint pain disappears, joint activities are free, and normal life and working ability are restored;

Significant effect: knee joint pain is significantly relieved, joint activities are slightly limited, and normal life and work can be maintained;

Effective: Knee joint pain is relieved, joint activities are improved, squatting, standing up, going up and down stairs can persist for a certain period of time;

Ineffective: The treatment has no effect.

1.4 Treatment group 1-3, use respectively the Chinese medicine composition of the different preparation of the embodiment of the present invention 1-3 to treat:

(1) Treatment group 1: 120 patients were diagnosed with knee osteoarthritis, treated with the patch of Example 1 of the present invention, and applied the patch to the affected area. Fix the patch with film or medical tape, remove it after 5 hours, 1-2 times a day, 7 days as a course of treatment, and use 5-10 courses of treatment continuously. One week after drug withdrawal, the follow-up consultation showed that the treatment effect of 69 patients was clinically cured, 28 patients had markedly curative effect, 15 patients had effective treatment effect, and 8 patients had ineffective treatment. During the treatment period, no other side effects caused by the drug were found. During the follow-up for half a year, all patients who were clinically cured had no symptoms of recurrence.

(2) Treatment group 2: 120 patients were diagnosed with knee osteoarthritis, treated with the capsule of Example 2 of the present invention, 3 times a day, 0.4g each time, 7 days as a course of treatment, continuous use for 5-10 days a course of treatment. One week after drug withdrawal, the follow-up consultation showed that the treatment effect of 67 patients was clinically cured, 25 patients had markedly curative effect, 19 patients had effective treatment effect, and 9 patients were ineffective. During the treatment period, no other side effects caused by the drug were found. During the follow-up for half a year, all patients who were clinically cured had no symptoms of recurrence.

(3) Treatment group 3: 120 patients were diagnosed with knee osteoarthritis, treated with the tablet of Example 3 of the present invention, 3 times a day, 2-3 tablets at a time, 7 days as a course of treatment, continuous use for 5 - 10 courses of treatment. One week after drug withdrawal, the follow-up consultation showed that the treatment effect of 65 patients was clinically cured, 27 patients showed marked effect, 17 patients had effective treatment effect, and 11 patients were ineffective. During the treatment period, no other side effects caused by the drug were found. During the follow-up for half a year, all patients who were clinically cured had no symptoms of recurrence.

2. Specific cases

Case 1: Sun Mou, male, 73 years old, had knee pain for many years and the X-shape of the knee showed bones. Be diagnosed as knee osteoarthritis through concrete examination, use the patch of embodiment 1 to treat, during use, patch is applied to affected part, and the place of sticking medicine needs to be cleaned in advance, fixes patch with plastic wrap or medical tape. Take it off after 5 hours, 2 times a day, 7 days as a course of treatment, 8 consecutive courses of treatment. One week after stopping the drug, the patient returned to the clinic. The pain in the knee joint disappeared, the joints moved freely, and the normal life and work ability were restored. During the treatment, no other side effects caused by the drug were found. During the follow-up for half a year, the patient did not have any recurrence symptoms.

Case 2: Zhang, female, 65 years old, had knee pain for many years and the X-shape of the knee showed a bony bone, the affected knee was stiff for <30 minutes; there was a bony friction rub, and was diagnosed as knee osteoarthritis after specific examination. Use the capsule of embodiment 2 to treat, every day 3 times, once 0.4g, 7 days is a course of treatment, use 8 courses of treatment continuously. One week after stopping the drug, the patient returned to the clinic. The pain in the knee joint was significantly relieved, the joint activities were slightly limited, and he was able to maintain normal life and work. During the treatment period, no other side effects caused by the drug were found. During the follow-up for half a year, the patient did not have any recurrence symptoms.

Case 3: Mr. Li, male, 60 years old, had knee pain for many years and the X-shape of the knee showed bone abscess, and the affected knee was stiff for <30 minutes; there was a bony friction rub. After specific examination, he was diagnosed as knee osteoarthritis. Use the tablet of embodiment 3, every day 3 times, once 2, 7 days are a course of treatment, use 8 courses of treatment continuously. One week after stopping the drug, the patient returned to the clinic. The pain in the knee joint was significantly relieved, the joint activities were slightly limited, and he was able to maintain normal life and work. During the treatment period, no other side effects caused by the drug were found. During the follow-up for half a year, the patient did not have any recurrence symptoms.

the

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the protection of the present invention. within range.

Claims (10)

1. a Chinese medicine composition for the treatment of knee osteoarthritis, characterized in that, the weight and number ratios of various raw materials in the Chinese medicine composition are: 10 to 20 parts of Angelica sinensis, 10 to 25 parts of Sangjisheng, 10-25 parts of Rhizoma Chuanxiong, 10-20 parts of Notopterygium, 10-50 parts of Duhuo, 10-20 parts of Gentiana, 10-20 parts of Guizhi, 10-20 parts of frankincense, 10-20 parts of woody incense, 10-25 parts of Mori twig , 10-20 parts of Agrimony, 10-20 parts of Eucommia, 10-20 parts of Rehmannia glutinosa, 10-20 parts of Corydalis Corydalis, 10-20 parts of Tibetan Clove, 10-20 parts of Miltonia Spatholobus, 10-25 parts of Achyranthes bidentata, three 10-20 parts of ribs, 10-20 parts of curcuma, 10-20 parts of aconite, 10-25 parts of curculigo, 10-25 parts of Morinda officinalis, 10-20 parts of soap core, 10-20 parts of salvia miltiorrhiza, 10-20 parts of safflower 25 parts, 10-20 parts of rhubarb, 10-20 parts of Panax notoginseng, 10-20 parts of sappan, 10-20 parts of cervus, 10-20 parts of skewer, 10-20 parts of terra vine and 10 parts of sea wind vine ~20 servings. 2. The Chinese medicine composition for treating knee osteoarthritis according to claim 1, characterized in that, the ratio of parts by weight of each raw material in the Chinese medicine composition is: Angelica 12～18 parts, Sangjisheng 15 parts ～22 parts, Chuanxiong 12～23 parts, Notopterygium 12～17 parts, Duhuo 17～42 parts, Gentiana 12～18 parts, Guizhi 12～18 parts, Frankincense 12～17 parts, Woody incense 11～19 parts, Mori twigs 14-21 parts, 11-18 parts of Agrimony, 10-20 parts of Eucommia, 10-20 parts of Rehmannia glutinosa, 10-18 parts of Corydalis Corydalis, 13-17 parts of Tibetan Clove, 12-20 parts of Miltonia Spatholobus, 15-20 parts of Achyranthes bidentata 25 parts, 12-20 parts of trigonum, 12-20 parts of curcuma, 10-20 parts of aconite, 10-25 parts of curculigo, 10-25 parts of Morinda officinalis, 12-17 parts of soap core, 10-20 parts of salvia, 10-25 parts of safflower, 10-20 parts of rhubarb, 10-20 parts of panax notoginseng, 10-20 parts of sumac, 10-20 parts of deer's grass, 10-18 parts of skewers, 13-17 parts of terrazzo 12-18 parts of Hefeng rattan. 3. The Chinese medicine composition for treating knee osteoarthritis according to claim 1 or 2, characterized in that, the ratio of parts by weight of each raw material in the Chinese medicine composition is: Angelica 16 parts, Sangjisheng 18 parts 17 parts of Rhizoma Chuanxiong, 15 parts of Notopterygium, 29 parts of Duhuo, 15 parts of Gentiana, 15 parts of Guizhi, 15 parts of frankincense, 15 parts of woody incense, 17 parts of Morus twig, 15 parts of Agrimony, 15 parts of Eucommia, 14 parts of Rehmannia glutinosa , 14 parts of Corydalis Corydalis, 15 parts of Tibetan Clove, 16 parts of Spatholobus Spatholobus, 21 parts of Achyranthes bidentata, 16 parts of Sanleng, 16 parts of Curcuma, 15 parts of Aconite, 18 parts of Curculigo, 17 parts of Morinda officinalis, 15 parts of soap core, 15 parts of Salvia miltiorrhiza, 17 parts of safflower, 15 parts of rhubarb, 15 parts of Panax notoginseng, 15 parts of sumac, 16 parts of mitten grass, 14 parts of skewer, 14 parts of syringa and 15 parts of sea wind vine. 4. a kind of preparation method for the treatment of the Chinese medicine composition of knee osteoarthritis as described in any one of claim 1-3, it is characterized in that, the dosage form of described Chinese medicine composition is patch, and described preparation method Include the following steps: a. Take the raw medicinal materials in the above weight-number ratio and put them into ethanol to heat and reflux for extraction twice to obtain extract 1; b. Then add water to heat and reflux the above-mentioned medicinal dregs extracted by ethanol to extract once to obtain extract 2; c. Combine extract 1 and extract 2 and concentrate to obtain medicinal extract; heat and concentrate for preparation. 5. the preparation method that is used for the treatment of the Chinese medicine composition of knee osteoarthritis according to claim 4 is characterized in that, in described step a, the raw material medical material that weighs by described weight and number ratio adds 10 times amount In 60-85% ethanol, heat and reflux for extraction twice, each time for 1-2 hours, leave the extract to stand to obtain extract 1, and the dregs for later use. 6. the preparation method of the Chinese medicine composition that is used for the treatment of knee osteoarthritis according to claim 4, is characterized in that, in described step b, the dregs extracted by ethanol in step a are heated and refluxed to extract twice , each time for 1-2 hours, the combined extracts were left standing to obtain the extract 2. 7. the preparation method that is used for the treatment of the Chinese medicine composition of knee osteoarthritis according to claim 4 is characterized in that, in described step c, extracting solution 1 and extracting solution 2 are merged, are pumped into decompression concentration tank Inside, depressurize to 0.03-0.08MPa, keep the temperature at 60-80°C, concentrate until the temperature is 60°C-70°C and the relative density is 1.20, heat and concentrate to paste, mix with wine, vinegar, and honey to get the patch . 8. a preparation method for the Chinese medicine composition for the treatment of knee osteoarthritis as described in any one of claim 1-3, it is characterized in that, the dosage form of described Chinese medicine composition is capsule, and described preparation method The method comprises the following steps: weighing all raw medicinal materials according to the ratio of parts by weight, pulverizing into coarse powder, further pulverizing, passing through a 100-120 mesh sieve, so that the amount of fine powder passing through the sieve reaches 30%, and collecting the fine powder passing through the sieve Obtain fine powder a; put the coarse powder that cannot pass through the 100 mesh to 120 mesh sieve into a multifunctional extraction tank for extraction twice, add 5-10 times the amount of water for decoction for 1-2 hours for the first time, and add 4- Decoct 8 times the amount of water for 1-2 hours, combine the two decoctions, filter to obtain the filtrate, heat and concentrate to a paste, put it in an oven at 80°C, dry it, cool it, grind it into fine powder b, mix fine powder a and fine powder b mixed and put into the capsule shell to obtain capsules. 9. a preparation method for treating knee osteoarthritis as described in any one of claim 1-3, is characterized in that, the dosage form of described Chinese medicine composition is a tablet, and described preparation method Include the following steps: a. Weigh Angelica sinensis, Sangjisheng and Chuanxiong according to the ratio of parts by weight, put them into 10 times the amount of 75% ethanol, heat and reflux for extraction twice, each time for 1-2 hours, extract active ingredients, and combine the two extracts Stand still to obtain extract 1; b. Weigh the remaining raw medicinal materials according to the ratio of parts by weight, put them into 10 times the amount of water, heat and reflux for extraction 3 times, each time for 30 minutes to 1 hour, combine the 3 extracts and let stand to obtain extract 2; c. Combine extract 1 and extract 2, recover ethanol under reduced pressure and concentrate until the concentration of the medicinal solution is 0.5 g crude drug/mL. After suction filtration, a filtrate with a relative density of 1.08 at 20°C is obtained; the volume of the filtrate is 10 L The macroporous adsorption resin column was eluted twice, first eluted with deionized water or distilled water with 10 times the volume of the resin column, and then eluted with 95% ethanol with 5 times the volume of the resin column, collected the ethanol eluate, removed the solvent, The raw material medicine is obtained, and starch or dextrin is added to compress into tablets to obtain tablets. 10. according to the Chinese medicine composition for the treatment of knee osteoarthritis described in any one of claim 1-3, it is characterized in that, the dosage form of described Chinese medicine composition is: tablet, sugar-coated tablet, film-coated tablet , enteric-coated tablets, capsules, hard capsules, soft capsules, oral liquids, buccal preparations, granules, granules, honeyed pills, powders, elixirs, solutions, injections, suppositories, plasters, syrups , powder, enema or patch.