CN103520654A - Chinese medicine composition for treating knee osteoarthritis and preparation method of Chinese medicine composition - Google Patents

Chinese medicine composition for treating knee osteoarthritis and preparation method of Chinese medicine composition Download PDF

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CN103520654A
CN103520654A CN201310508609.5A CN201310508609A CN103520654A CN 103520654 A CN103520654 A CN 103520654A CN 201310508609 A CN201310508609 A CN 201310508609A CN 103520654 A CN103520654 A CN 103520654A
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梁轶聪
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Abstract

The invention discloses a Chinese medicine composition for treating knee osteoarthritis. The Chinese medicine composition is prepared from the following active medicine materials: angelica sinensis, loranthus parasiticus, ligusticum chuanxiong, notopterygium root, radix angelicae pubescentis, gentiana macrophylla, cassia twig, frankincense, elecampane, ramulus mori, agrimonia pilosa, eucommia ulmoides, prepared rehmannia root, corydalis tuber, syringa tibetica, millettia dielsiana, the root of bidentate achyranthes, rhizoma sparganii, curcuma zedoaria, monkshood, rhizoma curculiginis, morinda officinalis, seed of gymnocladus chinensis baill, the root of red-rooted salvia, carthamus tinctorius, rheum officinale, pseudo-ginseng, caesalpinia sappan, pyrola, sambucuspwilliamsiip, Chinese starjasmine stem and kadsura pepper stem. The Chinese medicine composition for treating knee osteoarthritis mainly aims at tonifying kidney, strengthening bone, activating meridians to stop pain, activating blood to disperse stasis, dispelling the wind and coldness, and is a novel medicine which is simple and convenient in preparation process, small in toxic and side effect, convenient to administrate, easy to manufacture and low in cost.

Description

一种用于治疗膝骨关节炎的中药组合物及其制备方法 Chinese medicinal composition for treating osteoarthritis of the knee and preparation method

[0001] [0001]

技术领域 FIELD

[0002] 本发明涉及含有来源于植物、动物或矿物原料的医用配制品,特别涉及一种治疗膝骨关节炎的中药组合物及其制备方法。 [0002] The present invention relates to plant-derived, animal or mineral formulation medical material, and particularly to compositions containing a medicine and a preparation method of treating knee osteoarthritis.

[0003] [0003]

背景技术 Background technique

[0004] 骨性关节炎是一种慢性关节疾病,它的主要改变是关节软骨面的退行性变和继发性的骨质增生。 [0004] Osteoarthritis is a chronic joint disease, which changes are primarily and secondary degeneration of articular cartilage in osteoarthritis. 主要表现是关节疼痛和活动不灵活,X线表现关节间隙变窄,软骨下骨质致密,骨小梁断裂,有硬化和囊性变。 Mainly joint pain and activities are not flexible, X-ray joint space narrowing, subchondral bone density, trabecular bone fracture, hardened and cystic change. 关节边缘有唇样增生。 Joint edge of lip-like hyperplasia. 后期骨端变形,关节面凹凸不平。 Late deformable bone ends, a joint surface is uneven. 关节内软骨剥落,骨质碎裂进入关节,形成关节内游离体。 Peeling the articular cartilage, bone fracture into the joint, the joint is formed in a free form. 骨性关节炎又叫退行性关节炎,实际并非炎症,主要为退行性变,属关节提前老化,特别是关节软骨的老化。 Also known as degenerative arthritis, osteoarthritis, inflammation is not practical, mainly degeneration, premature aging metal joints, especially the aging of the articular cartilage. 骨性关节炎代表着关节的衰老,故称之为老年性关节炎。 Osteoarthritis represents the aging of the joint, so called senile arthritis. (一)中医对膝骨关节炎病名的认识 Understanding (a) to TCM for knee osteoarthritis disease name

膝骨关节炎属祖国医学“骨痹”、“腰腿疼”的范畴。 Knee osteoarthritis is a country medicine "Gubi" category "lumbago" in. 《证治准绳》曰:“上下腿细,唯膝为大,形如鹤膝”指出了“鹤膝风”的临床症状与膝关节炎后期的膝部肿大,胫骨萎缩比较相似。 "Treatment of the criterion," said: "up and down fine leg, the knee is the only large, shaped like a crane knee" points out, "Crane knee wind" clinical symptoms of knee arthritis and knee late swollen shin bone atrophy similar. 《素问•长刺节论》曰:“病在骨,骨重不可举,骨髓酸痛,寒气至,名曰骨痹。”《素问•气穴论》曰:“积寒留舍,荣卫不居,卷肉缩筋,肋肘不得伸,内为骨痹,外为不仁。”《千金方》指出骨痹进一步发展会累及于肾,变为“骨极”。 "Q • thorns Festival theory", saying:. "In bone disease, bone mass can not move, bone pain, to cold, it is called Gubi" "Q • cavitation theory", saying: "Integrated homes stay cold, Wing David is not home, volume shrinking tendons meat, rib elbow extension shall, within bone weakness, outside is inhumane. "" Qian "that Gubi further development will involve the kidney, to" bone pole. " 《素问•痹论》详细的论述了痹证的发病原因以及临床表现,根据病从四时受邪的部位提出“筋痹”、“皮痹”、“脉痹”、“骨痹”的概念,根据描述特异性症状“痹在于骨则重,在于脉则血涩而不流,在于筋则屈不伸,在于肉则不仁,在于皮则寒。”指出“病在骨,骨重不可举,骨髓酸痛,寒气至,名曰骨痹”;《景岳全书》云:“盖痹者闭也,以气血为邪所闭,不得通行而病也”、“风痹之证,大抵因虚者多,惟气血不充,故风寒得以入之,惟阴邪留滞,故经脉为之不利。”由此提出了“虚”、“邪”、“瘀”与本病产生的关系;清代王清任《医林改错》提出淤血致痹学说;《医经原旨》指出“风、寒、湿三气杂至,合而为痹…以冬遇此者为骨痹…故骨痹不已”;《医学纲目》云:“冬感风寒湿者,为骨痹,久不已则入于肾”;《诸病源候论• "Q • Bi theory" detailed discussion of the etiology and clinical manifestations Arthralgia, according to the disease that "muscle weakness", "skin Bi", "Pulse Bi", "Gubi" From four o'clock by the evil of the site concept, according to the description of specific symptoms "Bi in that the bone weight, wherein the blood pulse astringent not flow, wherein the flexor tendon is not stretched, wherein the meat is inhumane, wherein the skin is cold." pointed "disease in the bone, the bone can not be re- for, bone pain, to cold, it is called Gubi ";" Jing Yue Quan Shu, "says:" lid Bi were also closed to the evil blood is closed, and the disease also may not pass, "" wind weakness of the evidence, probably due to multiple virtual person, but blood is not sufficient, it is into the cold, but the lag Yinxie, so whom adverse meridians. "thus made" false "," evil "," stasis "produces the disease relationship; Wang Ren Qing "Correction of Medicine" proposed congestion induced paralysis doctrine; "Medical by the original purpose" that "wind, cold, wet three gas hybrid, combined into Bi ... in winter If this were to bone weakness ... so Gubi endless ";" Medical Checklist "goes:" a sense of wind cold winter who is Gubi, has been the long-suppressed into the kidney ";" treat patients on • 劳候》指出:“身居下焦,主腰脚,其气荣润骨髓,今肾虚受风寒,故令膝冷也”;《诸病源候论》曰:“肝主筋而藏血,肾主骨生髓,虚劳血损耗髓,故伤筋骨。”巢元方认为引起痹证的主要原因是体虚感邪,是在肾虚的基础上,感受风寒湿邪日久所致;《张氏医通》也指出“膝痛”的病因病机与“无有不因肝肾虚者,虚则风寒气袭之”相关。 Labor candidate, "pointed out:" reside under the coke, the main waist and feet, the gas Rongrun bone marrow, this deficiency by the cold, so make knee cold also ";" to treat patients, "said:" liver reinforcement and stores the blood, kidney bone . marrow, blood loss consumption marrow, so injured bones "nest element side that is the main cause Arthralgia physically weak sense of evil, is based on the kidney, due to falling feel the cold wind evil;" Doctor Chang through "also pointed out that" knee "of the etiology and pathogenesis," not because there is no liver and kidney virtual person, virtual the cold wind hit the "relevant. 说明肝肾亏虚,精血不足是膝骨关节炎发病的根本原因,而风寒湿三气的侵袭则是膝骨关节炎发病之标。 DESCRIPTION liver deficiency, fine blood is the root cause of knee osteoarthritis, and invasion of wind cold dampness three gas is arthritis of knee standard. 同时《华佗神方》则认为“骨痹,乃食欲不节伤于肾也。”说明膝骨关节炎的发生与饮食也有关系。 At the same time, "Hua Shen Fang" is that "Gubi, is improper appetite hurt the kidneys also." Indicating the occurrence of knee osteoarthritis and diet are also related. 临床诊断:1.有过膝部软组织损伤,但大多数人当时并未引起注意而无记忆。 Clinical diagnosis: 1 had knee soft tissue injury, but most people did not attract attention without memory. 2.膝关节疼痛和发僵,早晨起床时较明显,活动后减轻,活动多时又加重,休息后症状缓解。 2. The knee pain and stiff, the more obvious when the morning after the event reduced, activities and more time and aggravation, relief of symptoms after the break. 3.后期疼痛持续,关节活动明显受限,股四头肌萎缩,关节积液,甚至出现畸形和关节内游离体。 3. Late pain persists, joint activity was limited, quadriceps atrophy, joint effusion, deformity and even intra-articular loose bodies. 4.膝关节屈伸活动时可扪及摩擦音。 4. palpable knee flexion and extension activities fricative. 5.膝关节正、侧位X照片,显示髌骨、股骨髁、胫骨平台关节缘呈唇样骨质增生,胫骨髁间隆突变尖,关节间隙变窄,软骨下骨质致密,有时可见关节内游离体。 The knee, lateral X photograph showing the patella femoral condyle, tibial plateau as a lip-like edge joint osteoarthritis, tibial long tip mutation, joint space narrowing, subchondral bone density, sometimes visible intraarticular loose bodies. 治疗原则:本病治疗中药治疗膝骨性关节炎主要以补肾壮骨、通络止痛、活血化瘀、祛风散寒,配合针灸、激光、外治等法治疗。 Treatment Principle: this disease medicine treatment of knee osteoarthritis mainly Bushenzhuanggu Tongluozhitong, blood circulation, comfortable and easy method with acupuncture treatment, laser, and other external treatment.

[0005] 现代医学认为详细病因目前尚未明了,现已明确系多种因素造成关节软骨的破坏。 [0005] Modern medicine detailed cause is not yet clear, the Department is now clear cause damage to the articular cartilage of a variety of factors. 常与下列因素有关:①损伤:如关节内骨折、半月板损伤、骸骨脱位等原因造成的关节软骨损伤。 Often associated with the following factors: ① injury: articular cartilage injuries such as fractures caused by intra-articular, meniscal injury, dislocation of bones and other reasons. ②过度负重:由肥胖或膝关节内、外翻畸形而致关节面过度负重。 ② excessive weight: Inside obesity or knee valgus deformity may cause excessive weight-bearing articular surface. ③感染或炎症引起关节软骨破坏。 ③ infection or inflammation caused by destruction of articular cartilage. ④软骨下骨坏死,如关节内游离体,造成关节软骨面损坏。 ④ the subchondral bone necrosis, such as intra-articular loose bodies, resulting in damage to the articular cartilage.

[0006] 膝骨关节炎的治疗⑴宣传防病知识、保护关节:首先要让患者对该病有所认识,体育锻炼要循序渐进,防止关节过度运动和负重,避免关节机械性损伤。 [0006] treatment ⑴ promote disease prevention knowledge knee osteoarthritis, joint protection: to let patients have a better understanding of the disease, physical exercise should be gradual, to prevent excessive movement and weight-bearing joints, mechanical joints to avoid injury. 严重时应制动或石膏固定,以防畸形。 Severe braking or plaster should prevent deformity. 减轻体重,使用把手、手杖以减轻受累关节负荷。 Weight loss, using the handle, cane to relieve the load of the affected joint. 与职业有关者,应调换工作。 Job-related, you should change jobs. 进行有关肌肉群的锻炼,可保持和改善关节活动,以增强关节的稳定性。 Exercise-related muscle groups, can maintain and improve joint activities to enhance the stability of the joint. ⑵物理疗法:热疗、水疗、红外线、超短波、电刺激等均可增强局部血液循环、缓解肌肉紧张,减轻疼痛等症状。 ⑵ physical therapy: thermotherapy, hydrotherapy, infrared, FM, electrical stimulation can increase local blood circulation, relieve muscle tension, reduce pain and other symptoms. 牵引疗法对颈椎病神经根型患者效果较好,可以松弛肌肉,缓解疼痛,并能防止神经根相邻的组织形成粘连,但须在专科医生指导下进行。 Traction therapy for patients with nerve root type cervical spondylosis good effect, can relax muscles, relieve pain, and prevent nerve root tissue adjacent to the formation of adhesions, but shall be conducted under the guidance of specialists. ⑶推拿和中药:祖国医学的推拿、针灸治疗在减轻关节炎症状方面有明显效果;现有的中药帖剂可活血止痛,有时亦有良效,但存在副作用,且容易复发。 ⑶ massage and medicine: massage Chinese medicine, acupuncture treatment has a significant effect in reducing the arthritic symptoms; conventional medicine posts HuoXueZhiTong agents may sometimes have good effect, but there are side effects, and easy to relapse.

[0007]发明内容 [0007] SUMMARY OF THE INVENTION

[0008] 本发明所要解决的技术问题在于,提供了一种配方简单、制作工艺简便,毒副作用小且给药方便,药剂易于制造, 成本低廉的新药。 [0008] The present invention solves the technical problem is to provide a simple formula, simple production process, drug side effects and convenient administration, the agent is easy to manufacture, inexpensive drugs. 本发明采用不同药性的中药材,进行了科学配伍,能达到理想的治疗效果,且安全,毒副作用小,制备简单,能直达病灶,治愈时间短,治愈后不易复发。 The present invention uses different properties of herbal medicines, scientific compatibility carried out, to achieve the desired therapeutic effect, and safety, side effects of small, simple to prepare, can direct lesions, healing time is short, recurrence after healing.

[0009] 为解决上述技术问题,本发明提供一种用于治疗膝骨关节炎的中药组合物,所述中药组合物中各种原料药材的重量份数比为:当归10~20份,桑寄生10~25份,川芎10~25份,羌活10~20份,独活10~50份,秦艽10~20份,桂枝10~20份,乳香10~20份,木香10~20份,桑枝10~25份,仙鹤草10~20份,杜仲10~20份,熟地黄10~20份,延胡索10~20份,藏丁香10-20份,鸡血藤10~20份,牛膝10~25份,三棱10~20份,莪术10~20份,附子10~20份,仙茅10~25份,巴戟天10~25份,肥皂核10-20份,丹参10~20份,红花10~25份,大黄10~20份,三七10~20份,苏木10~20份,鹿衔草10~20份,扦扦活10~20份,络石藤10~20份,海风藤10~20份。 [0009] To solve the above problems, the present invention provides a method of treating osteoarthritis of the knee for the traditional Chinese medicine composition, parts by weight of said herbal medicinal raw materials composition ratio: 10 to 20 parts angelica, mulberry infested with 10 to 25 parts, Chuanxiong 10 to 25 parts, Rhizoma 10 to 20 parts, independent living, 10 to 50 parts, Gentiana 10 to 20 parts, Gui 10 to 20 parts, frankincense 10 to 20 parts, woody 10 to 20 parts, 10 to 25 parts mulberry, agrimony 10 to 20 parts, 10 to 20 parts Eucommia, Rehmannia 10-20 parts, 10-20 parts fumaric, clove possession 10-20 parts, 10-20 parts Millettia, Achyranthes 10 to 25 parts, 10 to 20 parts by triangular, Curcuma 10 to 20 parts, aconite 10 to 20 parts, from 10 to 25 parts Curculigo, Morinda 10 to 25 parts, 10-20 parts by nuclear soap, 10 to 20 salvia parts, safflower 10 to 25 parts, 10 to 20 parts rhubarb, Panax 10 to 20 parts, 10 to 20 parts by hematoxylin, Pyrolae 10 to 20 parts, 10 to 20 stick stick live parts, 10 to contact Ishido parts 20, 10 to 20 parts haifengteng.

[0010] 所述中药组合物中各原料药材的重量份数比优选为:当归12~18份,桑寄生15~22份,川弯12~23份,羌活12~17份,独活17~42份,秦艽12~18份,桂枝12~18份,乳香12~17份,木香11~19份,桑枝14~21份,仙鹤草11~18份,杜仲10~20份,熟地黄10~20份,延胡索10~18份,藏丁香13-17份,鸡血藤12~20份,牛膝15~25份,三棱12~20份,莪术12~20份,附子10~20份,仙茅10~25份,巴戟天10~25份,肥皂核12-17份,丹参10~20份,红花10~25份,大黄10~20份,三七10~20份,苏木10~20份,鹿衔草10~20份,扦扦活10~18份,络石藤13~17份,海风藤12~18份。 [0010] The traditional Chinese medicine composition in parts by weight of each raw material is preferably from herbs: Angelica 12 to 18 parts, Loranthaceae 15 to 22 parts, from 12 to 23 parts by River Bend, Rhizoma 12 to 17 parts, 17 to 42 living alone parts, Gentiana 12 to 18 parts, 12 to 18 parts by Gui, frankincense 12 to 17 parts, 11 to 19 parts woody, mulberry 14 to 21 parts, 11 to 18 parts by agrimony, Eucommia 10 to 20 parts, Rehmannia 10 to 20 parts, 10 to 18 parts fumarate, clove hidden parts 13-17, Millettia 12 to 20 parts, Achyranthes 15 to 25 parts, 12 to 20 parts by triangular, Curcuma 12 to 20 parts, 10 to 20 aconite parts, 10 to 25 parts Curculigo, Morinda 10 to 25 parts, 12-17 parts by nuclear soap, 10 to 20 parts of Salvia miltiorrhiza, safflower 10 to 25 parts, 10 to 20 parts rhubarb, Panax 10 to 20 parts, 10 to 20 parts by hematoxylin, Pyrolae 10 to 20 parts, 10 to 18 living skewer stick parts, contact Ishido 13 to 17 parts, 12 to 18 parts by haifengteng. [0011] 所述中药组合物中各原料药材的重量份数比还可以优选为:当归16份,桑寄生18份,川芎17份,羌活15份,独活29份,秦艽15份,桂枝15份,乳香15份,木香15份,桑枝17份,仙鹤草15份,杜仲15份,熟地黄14份,延胡索14份,藏丁香15份,鸡血藤16份,牛膝21份,三棱16份,莪术16份,附子15份,仙茅18份,巴戟天17份,肥皂核15份,丹参15份,红花17份,大黄15份,三七15份,苏木15份,鹿衔草16份,扦扦活14份,络石藤14份,海风藤15份。 [0011] The traditional Chinese medicine composition in parts by weight ratio of each medicinal material may further preferably: 16 parts angelica, mistletoe 18 parts, 17 parts of Rhizoma Chuanxiong, Rhizoma 15 parts, 29 parts of independent living, Gentiana parts 15, 15 Gui parts, 15 parts of frankincense, woody parts 15, 17 parts of mulberry, agrimony 15 parts, 15 parts Eucommia, Rehmannia glutinosa 14 parts, 14 parts of fumaric, clove possession 15 parts, 16 parts Millettia, Achyranthes 21 parts, triangular parts 16, 16 parts of Curcuma, tuber parts 15, 18 parts of Curculigo, Morinda 17 parts, 15 parts core soap, 15 parts of Salvia, safflower 17 parts, 15 parts rhubarb, Panax parts 15, 15 hematoxylin parts, Pyrolae 16 parts, 14 parts stick stick live, contact Ishido 14 parts, 15 parts haifengteng.

[0012] 为了更好的实现上述发明目的,本发明还提供了一种用于治疗膝骨关节炎的中药组合物的制备方法,所述中药组合物的剂型为贴剂,所述制备方法包括以下步骤: [0012] In order to realize the foregoing object, the present invention also provides a method for preparing a composition for the treatment of knee osteoarthritis medicine, the medicine dosage composition is a patch, the method comprises preparing the following steps:

a.取上述重量份数比的原料药材放入乙醇中加热回流提取2次,得提取液I ; . A ratio of parts by weight to take the above raw herbs into ethanol was heated at reflux for 2 times to obtain extract I;

b.再将上述乙醇提取的原料药材,加水加热回流提取I次,得提取液2 ; . B then ethanol extract of raw herbs above extraction with water was heated at reflux for I times to obtain extract 2;

c.将提取液I和提取液2合并,浓缩,得到药物浸膏;加热浓缩调制。 . The extract C and I 2 extracts were combined and concentrated to give the pharmaceutical extract; modulation concentrated by heating.

[0013] 其中,所述步骤a中,按所述重量份数比称取的原料药材加入10倍量60-85%的乙醇中,加热回流提取2次,每次I~2小时,将提取液静置,得提取液I,药渣备用。 [0013] wherein, said step a, the parts by weight ratio of the weighed raw herbs is added 10 times the amount of 60 to 85% ethanol and heated at reflux for 2 times, each I ~ 2 hours, extract I was allowed to stand to give the extract I, dregs standby.

[0014] 所述步骤b中,将步骤a中乙醇提取过的药渣加水加热回流提取两次,每次I~2小时,合并提取液静置,得提取液2。 [0014] In step b, the step a ethanol-extracted with water heated to reflux dregs extracted twice, each time I ~ 2 hours, and the combined extracts allowed to stand to give 2 extract.

[0015] 所述步骤c中,将提取液I和提取液2合并,抽入减压浓缩罐内,减压至 [0015] In step c, the extracted I and 2 were combined extracts were concentrated under reduced pressure pumped into the tank under reduced pressure to

0.03-0.08MPa,温度保持在60_80°C,浓缩至温度为60°C _70°C时相对密度为1.20,加热浓缩至糊状,用酒、醋、蜂蜜调和即得贴剂。 0.03-0.08MPa, the temperature was maintained at 60_80 ° C, a temperature and concentrated to a relative density of 1.20 60 ° C _70 ° C, it was heated and concentrated to a paste, to obtain patches with wine, vinegar, honey to reconcile.

[0016] 本发明还提供了一种用于治疗膝骨关节炎的中药组合物的制备方法,所述中药组合物的剂型为胶囊剂,所述制备方法包括以下步骤:按照重量份数比称取所有原料药材,粉碎成粗粉,再进一步粉碎,过100目~120目筛,使能通过筛的细粉量在达到30%,收集通过筛的细粉得细粉a ;再将不能通过120目筛的粗粉投入多功能提取罐提取两次,第一次加5-10倍量水煎煮1-2小时,第二次加4-8倍量水煎煮1-2小时,合并两次煎液,过滤得滤液,加热浓缩至糊状,放入烘箱80°C烘干后冷却,研磨成细粉b,将细粉a与细粉b混合后装入胶囊壳体中,即得胶囊剂。 [0016] The present invention further provides a method for preparing a composition for the treatment of knee osteoarthritis medicine, said herbal composition is a capsule dosage form, the manufacturing method comprising the steps of: in a weight ratio of said parts All raw herbs taken, pulverized into a coarse powder, and further pulverized and sieved through 100 mesh to 120 mesh sieve, so that the amount of fines through the sieve at 30% fines collected through a fine sieve; then can not be 120 mesh sieve coarse powder into the multifunction extraction tank and extracted twice, first adding 5-10 times the amount of boiling water for 1-2 hours, adding a second amount of boiling water for 1-2 hours 4-8 times, and the combined two decoction, filtering to obtain filtrate was heated and concentrated to a paste, placed in an oven at 80 ° C after drying was cooled, ground into powder, b, b powder and a fine powder mixed and filled into a capsule shell, i.e., to give capsules.

[0017] 本发明又提供了一种用于治疗膝骨关节炎的中药组合物的制备方法,所述中药组合物的剂型为片剂,所述制备方法包括以下步骤: [0017] The present invention also provides a method for treating osteoarthritis of the knee medicine composition, said herbal composition is a tablet dosage form, the manufacturing method comprising the steps of:

a、按照重量份数比称取当归、桑寄生和川芎,放入10倍量75%的乙醇中,加热回流提取2次,每次I~2小时,提取活性成份,将2次提取液合并静置,得提取液I ; a, a weight ratio of weighed parts Angelica and Ligusticum Loranthaceae, placed in 10-fold amount of 75% ethanol and heated at reflux for 2 times, each I ~ 2 hours, and extraction of the active ingredient, the combined extracts were twice allowed to stand to give extract I;

b、按照重量份数比称取除将当归、桑寄生和川芎的其他原料药材,放入10倍量水中,加热回流提取3次,每次30分钟~I小时,将3次提取液合并静置,得提取液2 ; B, a weight ratio of weighed parts except angelica, mistletoe, and other materials of medicinal Chuanxiong, placed in 10-fold amount of water, heated to reflux and extracted three times, 30 minutes each ~ I h, the combined extracts three times the static It is set to give 2 extract;

C、将提取液I和提取液2合并,减压回收乙醇并浓缩至药液浓度为0.5g生药/mL,抽滤后,滤液的相对密度为温度为20°C时1.08 ;将滤液经体积为IOL的大孔吸附树脂柱洗脱两次,先用10倍树脂柱体积的去离子水或蒸馏水洗脱,再用5倍树脂柱体积的95%乙醇洗脱,收集乙醇洗脱液,去除溶剂,得到原料药,加入淀粉或糊精压片,得片剂。 C, the extract I and 2 were combined extract, and concentrated under reduced pressure to recover the ethanol solution concentration of 0.5g crude drug / mL, after filtration, the filtrate is the relative density of the temperature is 20 ° C 1.08; volume of the filtrate elution IOL macroporous resin column twice, first with deionized water 10 times the volume of the resin or column eluted with distilled water and then five times the volume of resin column eluting with 95% ethanol, ethanol eluent were collected, removed The solvent to obtain the drug, added starch or dextrin tabletting to give tablets.

[0018] 所述中药组合物的剂型为:片剂、糖衣片剂、薄膜衣片剂、肠溶衣片剂、胶囊剂、硬胶囊剂、软胶囊剂、口服液、口含剂、颗粒剂、冲剂、蜜丸剂、散剂、丹剂、溶液剂、注射剂、栓齐ϋ、硬膏剂、糖浆剂、散剂、灌肠剂或贴剂。 [0018] The dosage medicine composition: tablets, sugar-coated tablets, film-coated tablets, enteric coated tablets, capsules, hard capsules, soft capsules, oral, buccal, granules , granules, pill, powder, Dan, solutions, injections, suppositories Qi ϋ, plasters, syrups, powders, or patches enema.

[0019] 本发明的中药组合物具有中药治疗膝骨性关节炎主要以补肾壮骨、通络止痛、活血化瘀、祛风散寒等为主;且制作工艺简便,毒副作用小且给药方便,药剂易于制造,成本低廉的新药。 [0019] The herbal composition of the present invention having a traditional Chinese medicine is mainly to knee osteoarthritis Bushenzhuanggu Tongluozhitong, blood circulation, and the like based comfortable and easy; and the production process is simple, and administration of toxic side effects convenient, easy to manufacture the drug, low-cost drugs. 本发明采用不同药性的中药材,进行了科学配伍,能达到理想的治疗效果,且安全,毒副作用小,制备简单,能直达病灶,治愈时间短,治愈后不易复发。 The present invention uses different properties of herbal medicines, scientific compatibility carried out, to achieve the desired therapeutic effect, and safety, side effects of small, simple to prepare, can direct lesions, healing time is short, recurrence after healing.

[0020] [0020]

具体实施方式 Detailed ways

[0021] 骨关节炎多见于中老年人,其特征是膝关节软骨的变性或破坏,软骨下骨质硬化,关节边缘骨赘形成。 [0021] Osteoarthritis common in the elderly, characterized by the degeneration or destruction of knee cartilage, subchondral bone sclerosis, osteophyte formation at the joint margins. 患者主要表现为膝关节疼痛、绞锁、功能障碍,严重者还可伴有关节肿胀、周围水肿、肌肉萎缩等。 The patient presented with pain in the knee, twist, dysfunction, severe cases can be accompanied by joint swelling, peripheral edema, muscle atrophy. 《素问•痹论》:“风寒湿三气杂至,合而为痹也。”《素问•长刺节论》:“病在骨,骨重不可举,骨髓酸痛,寒气至,名曰骨痹。”《张氏医通•膝痛》:“膝为筋之腑,膝痛无有不因肝肾虚者,虚则风寒湿气袭之。”均阐明了本病的中医病因病机。 "Q • Bi theory": "wind cold dampness three gas hybrid, combined into Bi also." "Q • thorns Festival": the "disease of bone, bone mass can not move, bone aches, chill to, name said bone Bi "" Doctor Chang through knee • ":.." knee tendons of organs, there are no knee pain is not due to liver and kidney virtual person, the virtual cold passage of moisture "are set forth in the etiology and pathogenesis of this disease machine. ”病机为长期慢性老损,气血不足,肝肾亏虚;加之风寒湿邪乘虚侵袭,留滞经络,气血瘀阻,日久气血瘀滞不行;阳虚寒凝,筋骨失去温熙,久而成骨痹。 "Old pathogenesis of chronic damage, lack of blood, liver and kidney deficiency; coupled with the invasion of wind cold dampness evil Cheng Xu, Liu Zhi meridians, blood stasis, blood stasis not falling; Yang Hanning, bones lose temperature Hee, a long time from Gubi.

[0022] 中药外敷疗法是临床上最常用的中医外治法之一,晋代葛洪著的《肘后方》,唐代孙思邈的《千金要方》、《千金翼方》,王涛著的《外台秘要》以及明代李时珍的《本草纲目》中所载的医疗方法都涉及到了中药外敷疗法。 [0022] Topical Application of Drug therapy is one of the most commonly used clinical Traditional Chinese Medicinal, Jin Ge Hong significant "rear elbow" Sun Ssu Tang "Prescriptions", "daughter wing side," of the Tao " Taiwan Miyao, "and Ming Li's" Compendium of Materia Medica "medical treatment contained in traditional Chinese medicine are related to the topical therapy. 由于经络有内属脏腑、外络肢节、沟通表里、贯穿上下的作用,所以不但能治疗局部病变,而且还可通过外敷达到治疗全身性疾病的目的。 Since the inner metal meridian organs, outer limb network, communication table, through the role of the upper and lower, so not only can the treatment of local lesions but also achieve the treatment by topical systemic disease. 药物通过)局部穴位的刺激作用,经过皮肤透入,激发经脉之气,促进脏腑气血运行,起到治疗作用;皮肤较薄,神经、血管比较丰富,因此脐部有较强而迅速的吸收能力,有良好的感受和传导功能,当用适宜的药物施治于脐部时,均能刺激局部的神经末梢,改善内脏及组织生理活动和病理变化,增强机体的免疫力和抗病能力。 Drugs through) stimulation of local points of penetration through the skin to stimulate the meridians of the gas, promote blood and viscera run, play a therapeutic role; thin skin, nerves, blood vessels rich, umbilical therefore there is a strong and rapid absorption ability, good feeling and conduction, when used in suitable pharmaceutical umbilical differentiation, can stimulate local nerve endings, and the physiological activities of organs and improve histopathological changes, enhance the body's immunity and disease resistance. 中药外敷集热疗、药疗、灸疗于一体,起到健脾止泻的作用,同时避免了口服和注射带来的不便和痛苦,家长和患儿易于接受,且药效持久,避免了肝脏的首过效应和胃肠因素的干扰和降解作用,减少个体差异,起效快, 药效强,无创伤,无痛苦,使用方便。 TCM herbs set thermotherapy, medication, moxibustion in one, played the role Jianpizhixie, while avoiding the inconvenience and pain of oral and injectable brought parents and children easy to accept, and the lasting effect, to avoid first-pass effect and gastrointestinal disturbance and degradation factors of the liver, reducing individual differences, rapid onset, high efficacy, non-invasive, painless, and easy to use.

[0023] 方中当归补血活血之功,川芎活血。 [0023] Prescription of power Angelica blood circulation, Chuanxiong blood. 羌活、独活、防风经祛风而利水消肿;红花经牛膝引经入络而去祛膝部瘀血;杜仲、熟地黄、延胡索、鸡血藤、怀牛膝、三棱、莪术、附子、蝎毒、仙茅、巴戟天、丹参以及红花等药材。 Notopterygium, independent living, wind and by expelling water swelling; safflower Achyranthes cited by the network via away knee remove blood stasis; eucommia, rehmannia, fumarate, Millettia, Achyranthes, triangular, Curcuma, aconite, scorpion venom, Curculigo, Morinda, Salvia and safflower and other ingredients. 用熟地黄、骨碎补、怀牛膝、补骨脂等可补益肝肾、强筋壮骨;方用鸡血藤、水蛭活血破瘀;方用熟地,可增强患者的免疫力,增强谷胱甘肽过氧化物酶的活性,抗血液凝固,降低过氧化脂质,能有效改善阴虚的症状;方用附子,具有抗炎,中枢性及外周镇痛,刺激细胞分泌白细胞介素-2,增强及调节机体免疫功能等作用;方用丹参,可增强机体免疫力,具有降血脂、抗动脉粥样硬化以及改善微循环等作用;方用延胡索,具有镇痛及镇静催眠的作用;方用仙茅,具有抗炎,促进巨噬细胞的增生及吞噬能力等作用;方用巴戟天,具有抗炎,增强抗疲劳能力等作用;方用全蝎,其性平味辛,具驱风通络之功效。 With Rehmannia, Drynaria, Achyranthes, psoralen can kidney tonic, sinews and bones; side with Millettia, leech blood Po Yu; Fang with Rehmannia, can enhance the patient's immune system, enhancing Valley activity of glutathione peroxidase, an anti-blood clotting, reduced lipid peroxidation, can effectively improve the symptoms of deficiency; aconite side, have anti-inflammatory, central and peripheral analgesia, stimulation of cells secrete IL - 2, enhancing and regulating the body's immune function; Salvia square, can enhance immunity, hypolipidemic, anti-atherosclerotic action and improve microcirculation; side with fumarate, having analgesic and sedative hypnotic effect; Curculigo side with, anti-inflammatory, proliferation and promote phagocytosis of macrophages and so on; side by Morinda, anti-inflammatory, enhancement of resistance to fatigue and the like; side with scorpion, its nature spicy, with carminative meridians effect. 诸药合用有滋补肾阳、补益肝肾、活血逐瘀、温煦肢节、气化水湿等功效。 Various drugs nourishing kidney, liver and kidney tonic, blood stasis, limb warmth, moisture and other effects gasification. 大黄、三七活血,凉血。 Rhubarb, Panax blood circulation, cooling. 仙鹤草活血凉血。 Agrimony blood cooling. 桑寄生、秦艽、桑枝等具有活血祛风的功效。 Mistletoe, Gentiana, mulberry and so has the effect of promoting blood circulation expelling wind. 桂枝通阳温经。 Gui Tong Yang Wenjing. 苏木,鹿衔草,扦扦活,络石藤,海风藤具有祛风通络。 Hematoxylin, deer grass title, skewer stick in live, contact Ishido, sea breeze rattan has Qufeng network.

[0024]当归,该品为伞形科植物当归的干燥根。 [0024] Angelica, the product is dried Umbelliferae angelica root. 秋末采挖,除去须根及泥沙,待水分稍蒸发后,捆成小把,上棚,用烟火慢慢熏干。 Autumn excavation, removal of fibrous roots and sediment, slightly until the water evaporated, and bind them in the small, on the shelf, pyrotechnic slowly smoked. 全当归根略呈圆柱形,根上端称“归头”,主根称“归身”或“寸身”。 Full angelica root slightly cylindrical, the upper end of the root called "go first" taproot "the final body" or "inch body." 支根称“归尾”或“归腿”,全体称“全归”。 Rootlets called "final end" or "return leg", all said "all go." 全当归既能补血,又可活血,统称和血;当归身补血,当归尾破血味甘;辛;苦;性温。 Angelica both whole blood, but also blood, and blood collectively; Angelica body blood, Angelica expelling sweet tail; oct; pain; warm. 归肝;心;脾经。 Liver; heart; spleen. 补血药;调经药;止痛药。 Blood medicine; menstruation medicine; painkillers. 补血;活血;调经止痛;润燥滑肠。 Blood; promoting blood circulation; relieving pain; moistening Hua Chang. 血虚诸证;月经不调;经闭;痛经;症瘕结聚;崩漏;虚寒腹痛;痿痹;肌肤麻木;肠燥便难;赤痢后重;痈疽疮疡;跌扑损伤。 Deficiency Syndromes; irregular menstruation; amenorrhea; dysmenorrhea; Zhengjia knot together; uterine bleeding; Deficiency abdominal pain; paralysis; numbness of the skin; intestinal dry will be very difficult; weight after dysentery; ulcer sore; injury or flutter.

[0025] 桑寄生,补肝肾;强筋骨;祛风湿;安胎。 [0025] Loranthaceae, liver and kidney; strong bones; rheumatism; tocolysis. 主腰膝酸痛;筋骨痿弱;肢体偏枯;风湿痹痛;头错目眩;胎动不安,崩漏下血。 Main waist and knee pain; weak muscles atrophy; limb hemiplegia; Fengshibitong; wrong head dizziness; fetal irritability, uterine bleeding blood. 用于风湿痹痛,腰膝酸软,筋骨无力,崩漏经多,妊娠漏血,胎动不安;高血压。 For Fengshibitong, weak waist, muscles weakness, bleeding was more endoleak pregnancy, fetal irritability; Hypertension. ①《本经》:主腰痛,小儿背强,痈肿,安胎,充肌肤,坚发、齿,长须眉。 ① "by": the main back pain, pediatric strong back, carbuncles, tocolysis, filling the skin, strong hair, teeth, long eyebrows. ②《别录》:主金疮,去痹,女子崩中,内伤不足,产后余疾,下乳汁。 ② "Do not record": the main gold sores, to paralysis, women's collapse, a lack of internal injuries, post-natal disease than the next milk. ③《药性论》:能令胎牢固,主怀妊漏血不止。 ③ "medicinal theory": make tire firm, the main pregnant pregnant more than Louxue. ④《日华子本草》:助筋骨,益血脉⑤《滇南本草》:生槐树者,主治大肠下血、肠风带血、痔漏。 ④ "Japan Hanako Materia Medica": help the bones, blood benefits ⑤ "Southern Yunnan Materia Medica": those born Ash, attending the large intestine in blood, intestinal wind blood, anal fistula. 生桑树者,治筋骨疼痛,走筋络,风寒湿痹。 And live mulberry, governance muscles pain, go veins, wind musculoskeletal. 生花椒树者,治脾胃寒冷,呕吐恶心翻胃;又用治梅疮毒,妇人下元虚寒或崩漏。 Those living prickly ash tree, cure stomach cold, nausea, vomiting, Fan Wei; and with the governance of plum sore, woman or roadway Deficiency uterine bleeding. ⑥《本草蒙筌》:散疮疡,追风湿,却背强腰痛。 ⑥ "Ben Cao Meng Quan": San sore, chasing rheumatism, lumbago but back strong. ⑦《生草药性备要》:消热,滋补,追风。 ⑦ "herbal medicine prepared to": elimination heat, nourishing, Herd. 养血散热,作茶饮,舒筋活络。 Nourishing heat, for tea, Shujin. ⑧《玉楸药解》:治痢疾。 ⑧ "Jade Catalpa drug solution": dysentery.

[0026] 秦艽,用于风湿痹痛,筋脉拘挛,骨节酸痛,日晡潮热,小儿疳积发热。 [0026] macrophylla, for rheumatism, tendons Spasm, joint pain, hot flashes daily Asr, infantile malnutrition heat. 1.《纲目》:"秦艽,手足不遂,黄疸,烦渴之病须之,取其去阳明之湿热也。阳明有湿,则身体酸疼烦热,有热则日哺潮热骨蒸。"2.《本草经疏》:〃秦艽,苦能泄,辛能散,微温能通利,故主寒热邪气,寒湿风痹,肢节痛,下水,利小便。 1. "outline": "Gentiana, hand, foot and fail to materialize, jaundice, thirst of the disease should be, whichever is hot and humid to wet Yangming Yangming also, the body sore vexed hot, hot day feeding the hot flashes bone. steam "2." Ben Cao Jing Shu ": 〃 Gentiana, can suffer leakage, octyl energy spread, lukewarm Tom Lee, so the main cold and heat evil, cold wind paralysis, limb pain, water, and diuresis. 性能祛风除湿,故《别录》疗风无问久新,及通身挛急。 Qufengchushi performance, so "Do not record" treatment wind, no longer ask new, and Tongshen twin needs. 能燥湿散热结,故《日华子》治骨蒸及疳热;甄权治酒疸解酒毒;元素除阳明风湿,及手足不遂,肠风泻血,养血荣筋;好古泄热,益胆气。 Dampness cooling knot, the "Hanako" cure rickets and bone steaming hot; Zhen right cure jaundice wine hangover; elements Yangming rheumatism, and hand, foot and fail to materialize, intestinal wind spilled blood, nourishing wing ribs addition; Haogu Xiere, the benefits of courage. 咸以其除湿散结,清肠胃之功也。 Salty its dehumidification relieves congestion, clear the stomach of power also. "3.《本草征要》:〃秦艽,长于养血,故能退热舒筋。治风先治血,血行风自灭,故疗风无问新久。入胃祛湿热,故小便利而黄疸愈也。〃 "3." Materia Medica to sign ": 〃 Gentiana, longer than blood, it could be getting a fever treating wind first rule of blood, blood MORALS from the off, so ask new treatment wind, no longer stomach dampness heat, so small convenience. and the more jaundice also .〃

川芎,活血祛瘀;行气开郁;祛风止痛。 Chuanxiong, stasis; qi Gloomy; chills and pain. 考证:出自《汤液本草》主治:治疗头痛之首选药物。 Research: from "soup liquid Materia Medica" Indications: treatment drug of choice headaches. 月经不调;经闭痛经;产后瘀滞腥痛;症瘕肿块;胸胁疼痛;头痛眩晕;风寒湿痹;跌打损伤;痈疽疮疡。 Irregular menstruation; dysmenorrhea amenorrhea; postpartum stasis fishy pain; Zheng Jia lump; chest pain; headache, dizziness; wind musculoskeletal; bruises; ulcer sore. 《本经》:主中风入脑头痛,寒痹,筋挛缓急,金创,妇人血闭无子。 "The Classic": the main stroke into the brain, headache, cold paralysis, spasms of urgency, gold record, closed blood woman without children. 《别录》:除脑中冷动,面上游风去来,目泪出, 多涕唾,忽忽如醉,诸寒冷气,心腹坚痛,中恶,卒急肿痛,胁风痛,温中内寒。 "Do not record": In addition to the brain cold move, to face the wind, to, the head tears, saliva more tears away quickly as drunk, all the cold air, strong pain trusted, the evil, death acute swelling, pain threatening wind, temperature in cold inside. 陶弘景:齿根出血者,含之多瘥。 TaoHongJing: tooth root bleeding, containing many recover from illness. 《药性论》:治腰脚软弱,半身不遂,主胞衣不出,治腹内冷痛。 "Medicinal theory": governance waist and feet weak, hemiplegia, the main afterbirth not, cure abdominal cold pain. 《日华子本草》:治一切风,一切气,一切劳损,一切血,补五劳,壮筋骨,调众脉,破症结宿血,养新血,长肉,鼻洪,吐血及溺血,痔瘘,脑痈发背,瘰疬瘿赘,疮疥,及排脓消瘀血。 "Japan Hanako Materia Medica": cure all wind, all gas, all strain, all the blood, up five workers, strong bones and muscles, tone the public pulse, break the crux of blood places, raising new blood, flesh, nose Hung, vomiting and female blood , hemorrhoids, brain abscess hair back, scrofula gall superfluous, sores, and drainage eliminate blood stasis. 《医学启源》:补血,治血虚头痛。 "Medical Origins": blood, blood deficiency headache cure. 王好古:搜肝气,补肝血,润肝燥,补风虚。 Good old King: Search qi, enrich blood, liver run dry, wind up empty. 《纲目》:燥湿,止泻痢,行气开郁。 "Outline": dampness, only Xie Li, Yu Qi open. 芎藭,血中气药也,肝苦急以辛补之,故血虚者宜之;辛以散之,故气郁者宜之。 Chuanxiong, blood gas medicine also, to acute liver oct fill the bitter, so advised of deficiency; oct to dissipate, the so advised of qi. 《左传》言麦麴、鞠穷御湿,治河鱼腹疾。 "Zuo Zhuan" Words wheat yeast, Ju Yu poor wet, river belly of the fish disease. 予治湿泻,每加二味,其应如响。 I wet cure diarrhea, plus two each flavor, it shall be as loud. 血痢已通而痛不止者,乃阴亏气郁,药中加芎为佐,气行血调,其病立止。 Bloody diarrhea than those who have access and pain, is yin qi, the drug was added as adjuvant Xiong, xue gas transfer, which stand only disease. 《本草衍义》:芎藭,今人所用最多,头面风不可闕也,然须以他药佐之。 "Ben Cao Yan Yi": Chuan Xiong, used by most people today, head, face, wind is not too Que, then he shall rank and file of medicine.

[0027] 羌活,味辛;苦;性温。 [0027] Notopterygium, spicy; bitter; warm. ①《药性论》:味苦辛,无毒。 ① "resistance": Bitterpungent, non-toxic. ②《医学启源》:《主治秘要》云:性温,味辛。 ② "Medical Origins": "Indications Miyao," cloud: warm, spicy. ③《汤液本草》:气微温,味苦甘,平。 ③ "Herbal Decoction": tepid gas, bitter sweet,. 入膀胱、肾经。 Into the bladder, kidney. ①《珍珠囊》:足太阳膀胱经。 ① "pearl sac": bladder full sun. 手太阳小肠②《汤液本草》:足太阳、厥阴经。 Hand Sun small intestine ② "Herbal Decoction": full sun, Jueyin. ③《本草蒙筌》:手、足太阳,足少阴、厥阴经。 ③ "Ben Cao Meng Quan": hands full sun, foot Shao, Jue Yin. 散表寒;祛风湿;利关节;止痛。 San Table cold; rheumatism; Lee joints; pain. 主外感风寒;头痛无汗;油印寒湿痹;风水浮肿;疮疡肿毒。 Main exogenous cold; headache, no sweat; mimeographed musculoskeletal; feng shui edema; sores. 用于阳痿遗精,遗尿尿频,腰膝冷痛,肾虚作喘,五更泄泻;外用治白癜风,斑秃。 For impotence, incontinence, frequent lassitude Leng Tong, kidney for asthma, Diarrhea; topical treatment of vitiligo, alopecia areata. 解表散寒,祛风胜湿,止痛。 Relieving cold, chills and wins wet, pain.

[0028] 独活,祛风胜湿;散寒止痛。 [0028] independent living, chills and wins wet; cold pain. 用于风寒湿痹;腰膝疼痛;少阴伏风头痛,头痛齿痛。 For wind musculoskeletal; waist and knee pain; Shao volts wind, headache tooth pain. 1.风寒湿痹。 1. wind musculoskeletal. 该品辛散苦燥,气香温通,功善袪风湿,止痹痛,为治风湿痹痛主药,凡风寒湿邪所致之痹证,无论新久,均可应用;因其主入肾经,性善下行,尤以腰膝、腿足关节疼痛属下部寒湿者为宜。 The product Xinsan bitter dry, fragrant air temperature through, good power and eradicates rheumatism, arthralgia ended, the main drug for the treatment of rheumatism, where the wind cold dampness of the evil caused by Arthralgia, whether new or old, can be applied; its main into the kidney, goodness down, especially waist, legs and feet joint pain by alpine under appropriate section. 治感受风寒湿邪的风寒湿痹,肌肉、腰背、手足疼痛,常与当归、白术、牛膝等同用,如独活汤(《活幼新书》);若与桑寄生、杜仲、人参等配伍,可治痹证日久正虚,腰膝酸软,关节屈伸不利者,如独活寄生汤(《千金方》)。 Treatment feel cold wind evil wind musculoskeletal, muscle, back, foot pain, often with angelica, Atractylodes, Achyranthes equivalent to use, such as soup live alone ( "live young book"); if the mistletoe, Eucommia, ginseng compatibility , can cure falling Arthralgia positive imaginary, waist and knees, joint flexion and extension disadvantaged, such as Duhuojisheng ( "Qian Jin Fang"). 2.风寒挟湿表证。 2. cold dampness card table. 该品辛散温通苦燥,能散风寒湿而解表,治外感风寒挟湿所致的头痛头重,一身尽痛,多配羌活、藁本、防风等,如羌活胜湿汤(《内外伤辨惑论》)。 The product Xinsan Warming bitter dry, cold dampness and wind energy spread of the table, governance exogenous cold dampness caused headaches heavy head, a pain to do, and more with Notopterygium, Ligusticum, wind, etc., as Notopterygium wins wet soup ( " within the trauma Doubts "). 3.少阴头痛。 3. Shao headaches. 该品善入肾经而搜伏风,与细辛、川芎等相配,可治风扰肾经,伏而不出之少阴头痛,如独活细辛汤(《症因脉治》)。 This product into the kidney and found good wind volts, and Asarum, Chuanxiong match, the wind disturbance can cure kidney, Shao volts instead of a headache, such as independent living Asarum soup ( "disease due to pulse governance").

[0029] 桂枝,辛;甘;性温。 [0029] Gui, suberic; Gan; warm. ①《医学启源》:气热,味辛甘。 ① "Medical Origins": gas heat, spicy and sweet. ②《本经逢原》:辛,甘,微温,无毒。 ② "this by every original": acrid, sweet, slightly warm, non-toxic. 入膀胱、心、肺经。 Into the bladder, heart, lung. ①《汤液本草》:入足太阳经。 ① "Herbal Decoction": the full sun. ②《雷公炮制药性解》:入肺经。 ② "Thunder concocted herbal solution": human lung. ③《药品化义》:入肝、肾、膀胱三经。 ③ "Drugs of justice": the liver, kidney, bladder triple. ④《本草求真》:入肌表,兼入心、肝。 ④ "Materia Medica truth": the muscular form, and into the heart, liver. 主治:散寒解表;温通经脉;通阳化气。 Indications: relieving cold; warm meridians; yang fluidizing gas. 主风寒表证;寒湿痹痛;四肢厥冷;经闭腹痛;症瘕结块;胸痹;心悸;小便不利。 Cold main table card; alpine arthralgia; cold limbs; amenorrhea abdominal pain; Zhengjia agglomeration; Chest; palpitations; urination. 用于风寒感冒,脘腹冷痛,血寒经闭,关节痹痛,痰饮蓄水,水肿,心悸,奔豚。 For cold cold, abdominal Leng Tong, amenorrhea cold blood, joints arthralgia, water phlegm, edema, heart palpitations, Bentun. 功发汗解肌,温经通脉,助阳化气,散寒止痛。 Jieji power sweating, Tongmai temperature, air-yang, pain and cold.

[0030] 乳香,调气活血,定痛,追毒。 [0030] frankincense, regulating qi and blood circulation, and pain, chasing poison. 治气血凝滞、心腹疼痛,痈疮肿毒,跌打损伤,痛经,产后瘀血刺痛。 Governance blood stagnation, confidants pain, carbuncle sores poison, bruises, dysmenorrhea, postpartum bleeding tingling. ①《别录》:疗风水毒肿,去恶气。 ① "Do not record": Spa Feng Shui poison swollen to foul smells. 疗风瘾疹痒毒。 Itchy rash drug addiction treatment wind. ②《本草拾遗》:疗耳聋,中风口噤,妇人血气,能发酒,理风冷,止大肠泄擗,疗诸疮令内消。 ② "Materia Medica": treatment deafness, stroke Koujin, woman blood, liquor can, air treatment, locking colon vent Pi, the treatment of various sores order cancellation. ③《日华子本草》:止霍乱,心腹痛。 ③ "Japan Hanako Materia Medica": only cholera, heart abdominal pain. 煎膏止痛长肉。 Jiangao pain flesh. ④《证类本草》:治不眠。 ④ "Syndrome of Materia Medica": governance does not sleep. ⑤《珍珠囊》:定诸经之痛。 ⑤ "pearl sac": given all through the pain. ⑥《纲目》:消痈疽诸毒,托里护心,活血定痛,伸筋,治妇人难产,折伤。 ⑥ "outline": eliminate ulcer of various drugs, Tory heart care, blood and pain, Lycopodium, governance woman dystocia, off injury. ⑦《本草从新》:治癫狂,止泄痢。 ⑦ "new Materia Medica": governance mania, only Xie Li. ⑧《要药分剂》:赤白痢腹痛不止者,加入乳香无不效。 ⑧ "to the drug sub-agent": red white diarrhea abdominal pain than those who join frankincense are all effective.

[0031] 木香,行气止痛;调中导滞。 [0031] woody, qi pain; tune in dredge. 主胞胁胀满足;脘腹胀痛;哎吐泄泻;痢疾后重。 Master cell satisfies threat inflation; abdominal pain, bloating; hey discharge diarrhea; weight after dysentery. 用于胸脘胀痛、泻痢后重、食积不消、不思饮食1.脾胃气滞之脘腹胀满或疼痛,嗳气,恶心呕吐。 A chest abdominal pain, weight after dysentery, food product Needless not eating 1. stomach stagnation of abdominal distention or pain, belching, nausea and vomiting. 2.湿浊中阻之胸闷腹胀,纳呆便溏。 2. The resistance of dampness in the chest, abdominal distension, poor appetite. 3.痰湿壅肺之咳嗽气喘。 3. cough phlegm obstructing lung asthma. 4.邪气,辟毒疫温鬼,强志,主淋露。 4. evil, the provision of drug epidemic temperature ghosts, Chi-keung, the main shower gel. 久服不梦寤魇寐。 Jiufu not Mengwuyanmei. (《本经》)5.消毒,杀鬼精物,温疟蛊毒,气劣气不足,肌中偏寒,引药之精。 ( "Classic") 5 Disinfection, ghost sperm killing was Gudu temperature and malaria, gas shortage inferior gas, muscle cold side, the cited finishing agent. (《别录》)桑枝,入肝经。 ( "Do not record") mulberry, into the liver. ①《得配本草》:入手太阴经。 ① "was equipped with Materia Medica": start with lunar by. ②《本草再新》:入肺、肾二经。 ② "Materia Medica and then new": lungs, kidney two classics. ③《本草撮要》:入手、足太阴经。 ③ "Materia Medica summary": start with the full moon. 祛风湿;通经络;行水气。 Rheumatism; meridian; water and gas lines. 主风湿痹痛;中风半身不遂;水肿脚气;肌体风痒。 Main Fengshibitong; stroke hemiplegia; beriberi edema; body wind itch. 用于肩臂、关节酸痛麻木。 For shoulder and arm, joint pain numbness. ①《本草图经》:疗遍体风痒干燥,脚气风气,四肢拘挛,上气,眼晕,肺气嗽,消食;利小便,兼疗口干。 ① "The draft": itch air drying treatment over the body, beriberi atmosphere, limb Spasm, on the air, feel dizzy, lung cough, digestion; diuresis, and dry mouth treatment. ②《本草蒙筌》:利喘嗽逆气,消掀肿毒痈。 ② "Ben Cao Meng Quan": Lee Asthma inverse gas, eliminating lift carbuncle swollen poison. ③《本草汇言》:去风气挛痛。 ③ "Materia Medica words": to ethos twin pain. ④《本草备要》:利关节,养津液,行水祛风。 ④ "Materia Medica prepared to": Lee joints, raising body fluid, expelling the water line. ⑤《玉楸药解》:治中风歪斜,咳嗽。 ⑤ "Jade Catalpa drug solution": governance stroke skew, cough. ⑥《本草再新》:壮肺气,燥湿,滋肾水,通经,止咳除烦,消肿止痛。 ⑥ "Materia Medica and then new": strong lung, dampness, Kidney water, pass through, cough Chufan, swelling and pain. ⑦《岭南采药录》:去骨节风疾,治老年鹤膝风。 ⑦ "Lingnan herbs recorded": joints to wind illness, treatment of senile Crane knee wind. ⑧《现代实用中药》:嫩枝及叶熬膏月艮,治闻血压,手足麻木。 ⑧ "Modern and practical medicine": Gen twigs and leaves Aogao month, cure smell blood pressure, numbness.

[0032] 仙鹤草,收敛止血,止痢,杀虫。 [0032] agrimony, convergence bleeding, dysentery, insecticide. 广泛用于各种出血之证,例如:吐血、尿血、便血、崩漏、咯血、衄血,赤白痢疾,劳伤脱力,痈肿,跌打,创伤出血等证。 A wide variety of evidence of bleeding, for example: hematemesis, hematuria, blood in the stool, uterine bleeding, hemoptysis, epistaxis, Chibai dysentery, injured workers out force, carbuncles, bruises, wounds and bleeding syndrome. ①《履巉岩本草》:“叶,治疮癣。”②《滇南本草》:“治妇人月经或前或后,赤白带下,面寒腹痛,日久赤白血痢。“③《生草药性备要》:”理跌打伤,止血,散疮毒。“④《百草镜》:”下气活血,理百病,散痞满;跌打吐血,血崩,痢,肠风下血。“⑤《植物名图考》:”治风痰腰痛。“⑥《伪药条辨》:”治瘰疬。“⑦《现代实用中药》:”为强壮性收敛止血剂,兼有强心作用。适用于肺病咯血,肠出血,胃溃疡出血,齿科出血,痔血,肝脓疡等症。“杜仲,杜仲性温,味甘,具有补肝肾、壮腰膝、强筋骨、安胎的功效。 ① "Lu crags Materia Medica": "Ye, boils ringworm." ② "Southern Yunnan Materia Medica":. "Governance woman or before or after menstruation, vaginal discharge, abdominal pain, cold surface, falling into red and white blood dysentery" ③ "life herbal medicine prepared to ":" Li Bonesetters, bleeding, sore scattered "④" herbs mirror ":." under qi and blood circulation, Li diseases, bulk or fullness; bone vomiting, lower vaginal bleeding, diarrhea, intestinal wind blood . "⑤" plant name, map test ":." treating wind phlegm back pain "⑥" counterfeit drugs identified ":." cure scrofula "⑦" modern and practical medicine ":" convergence is a strong hemostatic agent, both cardiac acting suitable for pulmonary hemoptysis, intestinal bleeding, bleeding ulcer, dental bleeding hemorrhoids blood, liver abscess embolism. "Eucommia, Eucommia warm, sweet, with liver and kidney, strong weak, strong bones, Ann efficacy tire. 杜仲对免疫系统、内分泌系统、中枢神经系统、循环系统和泌尿系统都有不同程度的调节作用,杜仲能兴奋垂体-肾上腺皮质系统,增强肾上腺皮质功能。 Duzhong on the immune system, endocrine system, central nervous system, circulatory system and urinary system has a different degree of regulation, gutta can be excited pituitary - adrenal cortex system to enhance adrenal function. 现代研究还发现,杜仲具有与党参、黄芪一样的免疫促进功能。 Modern research also found that Eucommia have Codonopsis, Astragalus promote the same immune function. 所有这些都证实了中国古代关于杜仲有“久服轻身耐老”的论述。 All this confirms the ancient Chinese Eucommia on the "Jiufu light-resistant old" exposition. 补肝肾,强筋骨,安胎。 Liver and kidney, strong bones, tocolysis. 治腰脊酸疼,足膝痿弱,小便余浙,阴下湿痒,胎漏欲堕,胎动不安,高血压。 Treatment lumbar pain, foot atrophy weak knees, urine over Zhejiang, wet vaginal itch, Tailou want to fall, fetal irritability, high blood pressure. 《玉楸药解》:〃益肝肾,养筋骨,去关节湿淫。 "Jade Catalpa drug solution": 〃 benefits kidney, raising the bones, joints go wet kinky. 治腰膝酸痛,腿足拘挛。 Governance waist and knee pain, leg foot Spasm. 〃《中华人民共和国药典》(2010年版一部):“补肝肾,强筋骨,安胎。用于肝肾不足,腰膝酸痛,筋骨无力,头晕目眩,妊娠漏血,胎动不安。”杜仲是名贵滋补药材,其有效成分中除了含有大量已知活性的药用成分外,还含有多种营养物质,营养物质是杜仲保健作用的重要物质基础。 〃 "Chinese Pharmacopoeia" (2010 edition a): ".. Liver and kidney, strong bones, tocolysis for liver and kidney deficiency, waist and knee pain, aching, weakness, dizziness, Louxue pregnancy, fetal movement disturbed" gutta It is a valuable nourishing ingredients, the active ingredient contained in addition to the large number of known pharmaceutical active ingredients, but also contain a variety of nutrients, nutrient important material base Eucommia health effects. [0033] 熟地黄,补血养阴,填精益髓。 [0033] Rehmannia, blood and yin, fill lean marrow. 应用1.血虚诸证。 Applications 1. Deficiency Syndromes. 本品甘温质润,补阴益精以生血,为养血补虚之要药。 The product quality of sweet warm run, in essence yin and blood, as to the drug nourishing tonic. 常与当归、白芍、川芎同用,治疗血虚萎黄,眩晕,心悸,失眠及月经不调、崩中漏下等,如四物汤);若心血虚心悸怔忡,可与远志、酸枣仁等安神药同用;若崩漏下血而致血虚血寒、少腹冷痛者,可与阿胶、艾叶等补血止血、温经散寒药同用,如胶艾汤。 Often with angelica, peony, Chuanxiong with the use of therapeutic blood deficiency chlorosis, dizziness, palpitations, insomnia and irregular menstruation, collapse leave out the other, as Siwutang); if efforts imaginary palpitation, with Polygala, Suanzaoren other sedative drug use; if uterine bleeding caused blood deficiency blood cold, lower abdomen Lengtong person, with gelatin, leaves and other blood hemostasis, warm and cold with drug use, such as plastic Ai Tang. 2.肝肾阴虚诸证。 2. liver and kidney all evidence. 本品质润入肾,善滋补肾阴,填精益髓,为补肾阴之要药。 This quality run into the kidney, good nourishing yin, fill lean marrow for kidney yin to the drug. 古人谓之“大补五脏真阴”,“大补真水”。 The ancients called the "true yin nourishing the five internal organs," "nourishing real water." 常与山药、山茱萸等同用,治疗肝肾阴虚,腰膝酸软、遗精、盗汗、耳鸣、耳聋及消渴等,可补肝肾,益精髓,如六味地黄丸;亦可与知母、黄柏、龟甲等同用治疗阴虚骨蒸潮热,如大补阴丸(《丹溪心法》)。 Often the yam, Cornus identical with, the treatment of liver and kidney, weak waist, emission, night sweats, tinnitus, deafness, diabetes and the like, can be liver or kidney, essence, as Liuweidihuang Pills; and also Anemarrhena, Treats , treatment with shells equivalents Yin Gu Zheng hot flashes, as Dabuyinwan ( "Danxi Heart"). 本品益精血、乌须发,常与何首乌、牛膝、菟丝子等配伍,治精血亏虚须发早白,如七宝美髯丹(《医方集解》);本品补精益髓、强筋壮骨,也可配龟甲、锁阳、狗脊等,治疗肝肾不足,五迟五软,如虎潜丸(《医方集解》)。 This product essence and blood, hair black, often with Polygonum, Achyranthes, dodder, such as compatibility, essence and blood deficiency treatment of premature graying, as Qibaomeirandan ( "The medical Annals"); the product replenishing marrow, strong gluten bone, can also be equipped with shells, Cynomorium, Woodwardia etc., treatment of liver and kidney deficiency, five late five soft, like a tiger potential pill ( "The medical Annals"). 此外,熟地黄炭能止血,可用于崩漏等血虚出血证。 In addition, carbon can Rehmannia hemostasis, and the like can be used for uterine bleeding deficiency syndrome.

[0034] 延胡索,活血;散瘀;理气;止痛。 [0034] The fumarate, blood; stasis; qi; pain. 主心腹腰膝诸痛;月经不调;症瘕;崩中;产后血晕;恶露不尽;跌打损伤。 Weak primary trusted all pain; irregular menstruation; pelvic mass; collapse; and post-natal blood halo; lochia; bruises. 用于胸胁、脘腹疼痛,经闭痛经,产后瘀阻,跌扑肿痛。 A chest, abdominal pain, dysmenorrhea, amenorrhea, postpartum blood stasis, swelling or flutter. 1.镇痛作用:延胡索粉有镇痛作用,其止痛效价约为阿片的1/100 ;延胡索总碱、延胡索甲素、乙素、丑素、癸素均有镇痛作用,以乙素较强.各种剂型以醇制浸膏及粉剂作用强。 1. analgesic effect: analgesic effect fumarate powder which opioid analgesic potency of about 1/100; total alkaloids fumarate, methyl fumarate element, B element, ugly Su, Su decyl have analgesic action, to prime B strong. various formulations and strong in ethanolic extract powder effect. 2.镇静、安定、催眠作用:延胡索乙素具有一定的镇静、安定作用,其左旋体为新型的中枢抑制剂,较大剂量时对兔、狗、猴有明显的催眠作用。 2. calm, stability, and hypnotic effects: Tetrahydropalmatine having certain sedative, neuroleptic activity, which is a novel L-body central inhibitor, larger doses to rabbits, dogs, monkeys significant hypnotic effect. 3.对消化系统的影响:去氢延胡索甲素有显著的抗大鼠实验性胃溃疡作用。 3. Effect on the digestive system: dehydroepiandrosterone fumarate A known notable Experimental Gastric Ulcer in Rats.

[0035] 藏丁香,微苦;涩;平。 [0035] possession of cloves, bitter; astringent; level. 功能主治:强筋壮骨;利湿消肿。 Indications: sinews and bones; dampness swelling. 主肾虚腰痛;营养不良性水肿;湿疹;跌打损伤。 Primary kidney back pain; malnutrition, edema; eczema; bruises.

[0036] 鸡血藤,活血舒筋;养血调经。 [0036] Millettia, blood Shujin; nourishing menstruation. 主手足麻木;肢体瘫痪;风湿痹痛;妇女有经不调;痛经;闭经补血,活血,通络。 Main numbness; paralysis; Fengshibitong; women was not adjusted; dysmenorrhea; amenorrhea blood, blood, meridians. 用于月经不调,血虚萎黄,麻木瘫痪,风湿痹痛。 For irregular menstruation, blood deficiency chlorosis, numbness, paralysis, rheumatism. 配益母草,活血化瘀、调经止痛;配苍术,理气化湿、辟秽去浊;配杜仲,补肾壮骨,通经止痛;配当归,补血活血。 With motherwort, blood circulation, relieving pain; with herb, gasification of wet processing, to the provision of foul cloud; with Eucommia, Bushenzhuanggu, menstrual pain; with Angelica, blood blood. 1.月经不调、痛经、闭经。 1. irregular menstruation, dysmenorrhea, amenorrhea. 本品苦而不燥,温而不烈,行血散瘀,调经止痛,性质和缓,同时又兼补血作用,凡妇人血瘀及血虚之月经病证均可应用。 This product is bitter but not dry, warm but not strong, xue stasis, relieving pain, gentle nature, and at the same time the role of blood, blood stasis and deficiency of the woman who menopathy certificate can be applied. 治血瘀之月经不调、痛经、闭经,可配伍当归、川芎、香附等同用;治血虚月经不调、痛经、闭经,则配当归、熟地、白芍等药用。 Rule menstruation blood stasis, dysmenorrhea, amenorrhea, compatible angelica root, Cyperus equated with; treatment deficiency irregular menstruation, dysmenorrhea, amenorrhea, with the foxglove, and other medicinal TGP. 2.风湿痹痛,手足麻木,肢体瘫痪及血虚萎黄。 2. Fengshibitong, numbness, paralysis of limbs and blood deficiency chlorosis. 本品行血养血,舒筋活络,为治疗经脉不畅,络脉不和病证的常用药。 This conduct blood and blood, getting a vivid, for the treatment of poor meridians and collaterals are not commonly used drugs Syndrome. 如治风湿痹痛,肢体麻木,可配伍祛风湿药,如独活、威灵仙、桑寄生等药;治中风手足麻木,肢体瘫痪,常配伍益气活血通络药,如黄芪、丹参、地龙等药;治血虚不养筋之肢体麻木及血虚萎黄,多配益气补血药之黄芪、当归等药用。 The rule Fengshibitong, numbness, rheumatism compatible drugs, such as independent living, Clematis, mistletoe and other drugs; treatment of stroke numbness, paralysis, often compatibility lthe drugs, such as astragalus, Salvia, the Long and other drugs; treatment deficiency numbness and do not raise blood deficiency chlorosis tendons, and more with Qi tonic medicine of Astragalus, angelica and other medicinal. 3.治放射性白血球减少症:配合其他滋补气血的药物同用。 3. Treatment of radioactive leukopenia: in conjunction with other drugs with the use of nourishing blood.

[0037] 牛膝,1.《滇南本草》:治疔疮、痈疽,敷患处。 . [0037] Achyranthes, 1 "Southern Yunnan Materia Medica": governance boils, ulcer, wrap the affected area. 亦能打胎。 Can also abortion. 同猪肉煨食之,能明目。 With pork simmer eat, can eyesight. 2.《中药形性经验鉴别法》:有利尿、强精、通经之效。 2. "Chinese sexual experience shape identification method": a diuretic, strong fine, pass through effect. 能舒筋活血,专治腰膝疼痛。 Can Shujinhuoxue, cures waist and knee pain. 3.《本经》:主寒湿痿痹,四肢拘挛,膝痛不可屈,逐血气,伤热火烂,堕胎。 3. "by": main alpine paralysis, limb Spasm, knee can not bend, by blood, heat injury rotten, abortion. 4.《别录》:疗伤中少气,男肾阴消,老人失溺,补中续绝,填骨髓,除脑中痛及腰脊痛,妇人月水不通,血结,益精,利阴气,止发白。 4. "do not record": less gas in healing, M yin elimination, drowning out the elderly, continued must fill in, fill the bone marrow, in addition to the brain pain and lumbar pain, the woman on the water barrier, blood knot, essence, Lee chi, only white. 5.《药性论》:治阴痿,补肾填精,逐恶血流结,助十二经脉。 5. "resistance": cure impotence, Bushentianjing, by bad blood knot, help twelve meridians. 6.《日华子本草》:治腰膝软怯冷弱,破症结,排脓止痛,产后心腹痛并血运,落胎,壮阳。 6. "Japan Hanako Materia Medica": governance waist and knee soft cowardly weak cold, break the crux of pus and pain, postpartum pain and heart blood supply, off the tires, impotence. 7.《本草衍义》:与苁蓉浸酒服,益肾;竹木刺入肉,捣烂罨之,即出。 7. "Herbal Yan Yi": Cistanche soaked with wine service, kidney; wood piercing meat mash foment, namely the. 中医认为,其性味苦甘酸平,具有活血通经,补肝肾,强筋骨,利尿通淋,引血(火)下行之功效,常用于治疗瘀血阻滞的经闭、痛经、月经不调、产后腹痛等妇科病,跌打损伤,肾虚之腰膝酸痛、下肢无力,尿血,小便不利,尿道涩痛以及火热上炎引起的头痛、眩晕、吐血、衄血等证。 Chinese medicine believes that its bitter creatinine level, with blood circulation, liver and kidney, strong bones, diuretic Tonglin, blood lead (fire) the effectiveness of the downlink, amenorrhea commonly used in the treatment of blood stasis, dysmenorrhea, menstrual tone, postpartum abdominal pain, gynecological diseases, bruises, the kidney of the waist and knee pain, lower limb weakness, hematuria, dysuria, urinary astringent pain and headaches caused by inflammation of the fiery, dizziness, vomiting, epistaxis and other evidence. 1.怀牛膝功偏滋补肝肾,壮腰膝:用于肝肾不足引起的筋骨酸软、腰膝疼痛。 1. Partial Achyranthes nourishing liver and kidney function, strong weak: for bones caused by liver and kidney deficiencies and knees, painful waist and knee. 2、川牛膝以活血通经,祛风湿见长:用于血瘀经闭及风湿痛。 2, Cyathula to blood circulation, rheumatism known: for blood stasis amenorrhea and rheumatism. 本品性善下行,专治上炎之火及上部出血,故常用于虚火上炎或血热上冲之目赤、咽肿、吐血、衄血等症。 This product goodness downlink, the fire of inflammation cures and an upper bleeding, inflammation and so are used on Chong virtual fire or heat blood red eyes, throat swelling, hematemesis embolism.

[0038] 三棱,味苦,性平。 [0038] Tri, bitter, flat. 破血,行气,消积止痛。 Expelling, Qi, Xiaojizhitong. 临床应用:适用于多种肿瘤,如卵巢癌、宫颈癌、肝癌等。 Clinical application: for a variety of tumors, such as ovarian cancer, cervical cancer, liver cancer and the like. 常与香附、莪术、紫草根、木馒头等配伍治疗气血结积、瘀血瘀滞的卵巢癌、宫颈癌等。 Often with Cyperus, Curcuma, purple grass, bread and other wood product combination on the blood knot, blood stasis ovarian cancer, cervical cancer and so on. 常用白花蛇舌草、大腹皮、茯苓、莪术等配伍治疗气滞血瘀、热毒蕴结的肝癌。 Common diffusa, Arecae, Poria, Curcuma combination on blood stasis, toxic heat Accumulation of liver cancer. 此外该品还适用于血瘀气滞、腹部结块、肝脾肿大、经闭腹痛、食积胀痛等。 In addition, the product is also suitable for gas stagnation blood stasis, blocking the abdomen, hepatosplenomegaly, amenorrhea abdominal pain, pain and other food product.

[0039] 莪术,I)破血行气止痛:本品功效与三棱相似,但温通力较大,可治疗血滞经闭腹痛、腹部包块、积聚。 [0039] Curcuma, I) expelling gas pain: the efficacy of this product is similar to triangular, but larger Kone temperature, blood stagnation amenorrhea treat pain, abdominal mass accumulation. 2)积散结:本品能行气消积止痛,用于饮食积滞、胸腹满闷作痛。 2) Sanjie: This product do gas Xiaojizhitong for food stagnation, abdominal ache stuffiness. 3)破血祛瘀,妇女闭经,或痰湿淤血凝结而成的症瘕癖块。 3) expelling blood stasis, women amenorrhea, or phlegm congestion condensed block of Zhengjia addiction. 4)行气止痛:适于饮食失调,脘腹涨满疼痛之证。 4) gas pain: is adapted to eating disorders, abdominal pain swell the card. 适当配伍,虚症、实症均可。 Appropriate compatibility, Xu Zheng, real disease can be. 多生用。 Have more use. 5)注意事项:孕妇忌用 5) Note: a pregnant woman

附子,回阳救逆,补火助阳,散寒止痛。 Aconite, Yang deficiency, make up the fire yang, cold pain. “为回阳救逆第一品药”用于阴盛克阳,大汗亡阳,吐泻厥逆,肢冷脉微,心腹冷痛,冷痢,脚气水肿,风寒湿痹,阳痿,宫冷,虚寒吐泻,阴寒水肿,阳虚外感,阴疽疮疡以及一切沉寒痼冷之疾。 "Yang deficiency is the first drug product" for the female Shengke Yang, Yang death sweat, vomiting and diarrhea Jueni, cold extremities pulse, confidants Leng Tong, cold dysentery, beriberi edema, wind musculoskeletal, impotence, cold uterus, virtual cold vomiting and diarrhea, chill edema, exogenous Yang, Yin Shen cold sore and all inveterate cold of the disease. 而且附子对垂体一肾上腺皮质系统有兴奋作用,还能兴奋迷走神经而具强心作用。 And aconite excitatory effects on the pituitary-adrenal cortex system, but also excited vagus nerve with a strong heart. 附子不宜与豉汁一起食用,主要是因为豆豉气味苦寒或咸寒。 Aconite should not be eaten with soy sauce, tempeh mainly because of the smell of bitter cold salty or cold. 而附子则是大辛大热的药物,为温里回阳药,两者药性相反,同时食用会降低药效。 The aconite is hot Okara drugs, drugs for the warm sun in the back, on the contrary both potency, while consumption will reduce the efficacy.

[0040] 仙茅,补肾阳,强筋骨,散寒湿。 [0040] Curculigo, kidney yang, strong bones, cold and wet. 治阳萎精冷,小便失禁,崩漏,心腹冷痛,腰脚冷痹,痈疽,瘰疬,阳虚冷泻。 Fine cold cure impotence, urinary incontinence, uterine bleeding, confidants Leng Tong, waist and feet cold paralysis, ulcer, scrofula, Yang cold diarrhea. 阳痿精寒,腰膝风冷,筋骨痿痹等症。 Impotence fine cold, waist and air-cooled, muscles paralysis embolism. 古方中有仙茅丸,能壮筋骨、益精神、明目、黑须发。 Ancient Prescription pills have Curculigo, can strong bones, the benefits of the spirit, eyesight, black hair. ①《海药本草》:主风,补暖腰脚,清安五脏,强筋骨,消食。 ① "Sea herbal medicine": the main wind, waist and feet warm up, clearing the five internal organs, strong bones, digestion. 宣而复补,主丈夫七伤,明耳目,益筋力,填骨髓,益阳。 Vision undone up, the main husband and injured seven, clear eyes and ears, the benefits of gluten, fill the bone marrow, Yiyang. ②《日华子本草》:治一切风气,补五劳七伤,开胃下气。 ② "Japan Hanako Materia Medica": cure all atmosphere, up five workers and injured seven, appetizers under the gas. ③《开宝本草》:主心腹冷气不能食,腰脚风冷挛痹不能行,丈夫虚劳,老人失溺。 ③ "Kai Bao Materia Medica": the main cold air can not eat confidant, waist and leg paralysis can not be air-cooled twin line, consumptive husband, the elderly lose drowning. ④《滇南本草》:治妇人红崩下血,攻痈疽,排脓。 ④ "Southern Yunnan Materia Medica": governance woman blood red collapse under attack ulcer, pus. ⑤《生草药性备要》:补肾,止痛,治白池,理痰火,煲肉食。 ⑤ "of herbal medicine prepared to": kidney, pain, cure white pool, the rationale pyrophlegm, pot meat. 十蒸九晒,用沙糖藏好,早晨茶送,能壮精神,乌须发。 Ten nine steam drying, with Shatang possession of a good, morning tea to send, to the spirit of strong, black hair. ⑥《玉楸药解》:治皮肤风癞。 ⑥ "Yu Catalpa drug solution": governance wind scabies skin.

[0041] 巴戟天,肾虚阳痿;遗精早泄;少腹冷痛;小便不禁;宫冷不孕;风寒湿痹;腰膝酸软;风湿肢气。 [0041] Morinda, kidney impotence; emission, premature ejaculation; Lengtong lower abdomen; urine can not help; cold uterus infertility; wind musculoskeletal; Yaoxisuanruan; rheumatoid limbs gas. 赞育丹《景岳全书》:补肾壮阳。 Tsan Yuk Dan "Jing Yue Quan Shu": kidney impotence. 毓麟丸《经验方》:男子不育、女子不孕。 Yulin pill "experience side": male infertility, women infertility. 苁蓉补虚益气方《备急千金方》:五脏虚劳;金刚丸《张氏医通》:肾虚肾痿。 Cistanche Qi tonic side "emergency preparedness Qian": Consumption internal organs; adamantyl pill "Doctor Chang Tong": kidney renal atrophy. [0042] 肥皂核,甘;温。 [0042] Nuclear soap, Gan; temperature. 归肺;心;大肠经。 In the lungs; heart; large intestine meridians. 功能主治:祛痰;通便;利尿;杀虫。 Indications: expectorant; laxative; diuretic; insecticide. 主顽痰阻塞;大肠风秘;下痢;淋证;疥癣。 Main stubborn phlegm obstruction; E. winds secret; diarrhea; shower cards; scabies.

[0043] 丹参,具有活血散淤、消肿止血、消炎止痛、调经止痛、扩张冠状动脉、改善心肌缺血状况、降低血压、安神静心、降血糖和抗菌等功效,对月经不调,经闭痛经,症瘕积聚,胸腹刺痛,热痹疼痛,疮疡肿痛,心烦不眠;肝脾肿大,心绞痛等病症有一定的疗效。 [0043] Salvia, with blood scattered silt, swelling and bleeding, inflammation pain, menstrual pain, coronary artery expansion, improve myocardial ischemia condition, lower blood pressure, meditation soothe the nerves, blood glucose lowering effect and antibacterial, irregular menstruation, amenorrhea dysmenorrhea, Jia accumulation, abdominal tingling, hot Bi pain, sore throat, upset, insomnia; hepatosplenomegaly, angina and other diseases have a certain effect. 此外,近代医学实验证明,丹参还具有抗血小板凝聚、降低血液黏度及调节内外凝血系统的功能,是一种安全又可靠的治疗心脏血管疾病的天然中药。 In addition, modern medical experiments proved that Salvia also has anti-platelet aggregation, reduce blood viscosity and regulate the function of the coagulation system inside and outside, is a safe and reliable treatment of cardiovascular disease, natural medicine. 用于胸肋胁痛,风湿痹痛,症瘕结块,疮疡肿痛,跌仆伤痛,月经不调,经闭痛经,产后瘀痛等。 For Sternocostal hypochondriac, rheumatism, Zhengjia agglomeration, sore throat, pain or servant, irregular menstruation, dysmenorrhea, amenorrhea, postpartum pain stasis. 治疗胸肋疼痛、症瘕结块,以及月经不调、经闭经痛具有良效,常与川芎配伍应用。 Sternocostal treating pain, pelvic mass agglomeration, and irregular menstruation, pain, amenorrhea with good effect, often with Rhizoma Chuanxiong application. 在治疗胸腹疼痛属于气滞血瘀方面,往往配合砂仁、檀香等药同用。 In the treatment of abdominal pain belong stagnation aspect, often with villosum, sandalwood and other drug use. 用于温病热入营血、身发斑疹、神昏烦躁。 For febrile disease heat penetrating the blood, body fat rash, coma irritability. 常与鲜地黄、水牛角、玄参等药同用。 Often with fresh yellow, buffalo, Scrophulariaceae other drug use. 用于心悸怔忡、失眠。 For palpitation and insomnia. 常与酸枣仁、柏子仁等药配合同用。 Often in conjunction with Semen, Bozi other drug use.

[0044] 红花,性温,味辛,活血通经、散瘀止痛。 [0044] Safflower, warm, spicy, promoting blood circulation, Sanyu pain. 用于经闭、痛经、恶露不行、症瘕痞块、跌打损伤。 For amenorrhea, dysmenorrhea, lochia not, Zhengjia lump, bruises. 古人常有於血在体内时,常加红花一小把。 Ancient often in the blood in the body, often with a wisp safflower. 纱布包煮开可用一天两次泡脚,适用各种静脉曲张,末梢神经炎,血液循环不好,腿脚麻木或青紫等淤血症。 Gauze can be used to boil their feet twice a day, for a variety of varicose veins, peripheral neuritis, poor blood circulation, such as legs and feet numbness or bruising congestion syndrome. 经血不调,产后腹痛,症瘕,外伤瘀血肿痛,痈疽肿痛等症。 Blood does not transfer, postpartum abdominal pain, pelvic mass, trauma, bleeding throat, ulcer sore embolism. 出自《本草图经》红蓝花,即红花也。 From "The sketches by" red and blue flowers, red flower that is also. 今处处有之。 This everywhere with them. 人家场圃所种,冬而布子于熟地,至春生苗,夏乃有花,下作梂汇,多刺,花蕊出梂上,圃人承露采之,采已复出,至尽而罢。 People Farms planted, cultivated land in sub-cloth and winter, to spring seedlings, summer is the flowers, mainly as Qiu Hui, spiny, a flower on Qiu, Lu Cheng-po people of mining, mining has come back to try and stop. 梂中结实,白颗,如小豆大。 Qiu the solid, white teeth, as adzuki large. 其花暴干以染真红,及作燕脂。 The flowers storms do to really dyed red, and for Yan fat. 主产后血病为胜。 Postpartum main leukemia for the win. 其实亦同。 In fact likewise. 叶颇似蓝,故有蓝名。 It leaves resembling blue, so blue name. ”《本草述钩元》红蓝花,养血水煎,破血酒煮。” "" Herbal above the hook dollars "red and blue flowers, nourishing decoction, expelling Jiuzhu."

大黄,攻积滞;清湿热;泻火;凉血;祛瘀;解毒。 Rhubarb, attack stagnation; clear heat; purging fire; cooling; removing blood stasis; detoxification. 主治:实热便秘;热结胸痞;湿热泻痢;黄疸;淋病;水肿腹满;小便不利;目赤;咽喉肿痛;口舌生疮;胃热呕吐;吐血;咯血;紐血;便血;尿血;蓄血;经闭;产后瘀滞腹痛;症瘕积聚;跌打损伤;热毒痈疡;丹毒;烫伤。 Indications: Heat constipation; hot junction Xiongpi; heat dysentery; jaundice; gonorrhea; Fu Man edema; urination; red eyes; sore throat; mouth sores; stomach vomiting; vomiting; hemoptysis; New blood; stool; blood in the urine; Xuxue; amenorrhea; postpartum stasis abdominal pain; pelvic mass accumulation; bruises; toxic heat carbuncle ulcers; erysipelas; burns.

[0045] 三七,田七的功效作用很大,其性温,味辛,具有散淤止血,消肿定痛的功效,可用于治疗衄血、便血、崩漏、咯血、 吐血、外伤出血、胸腹刺痛等症。 [0045] Panax, a great effectiveness of the role of pseudo-ginseng, its warm, spicy, having scattered silt bleeding, swelling and pain effect, useful for treating epistaxis, hematochezia, uterine bleeding, hemoptysis, hematemesis, traumatic bleeding , chest and abdomen tingling embolism. 而且田七中的黄酮类化合物具有改善心肌供血、增加血管弹性、扩张冠状动脉的功效,谷留醇和胡萝卜甙能降血脂。 And the pseudo-ginseng flavonoids having improved myocardial blood supply, increasing the elasticity, the effect of expansion of coronary artery, left valley alcohol daucosterol lowering blood pressure. 常食田七,对冠心病、心绞痛有预防和治疗作用。 Vegetables Tianqi, the prevention and treatment of coronary heart disease, angina. 归肝经;胃经;心经;肺经;大肠经。 Owned by the liver; stomach; Heart Sutra; lung; large intestine meridians. 功能:止血;散血;定痛。 Function: hemostasis; casual blood; and pain. 禁忌:气血亏虚所的痛经、月经失调不宜选用,其表现为经期或经后小腹隐痛喜按。 Contraindications: blood deficiency as dysmenorrhea, menstrual disorders should not use, its performance for the period after abdominal pain or joy press. 主治:跌扑瘀肿,胸痹绞痛,症瘕;血瘀经闭;痛经;产后瘀阴腹痛;疮痈肿痛。 Indications: flutter bruising, Chest Pain cramps, abdominal mass; blood stasis amenorrhea; dysmenorrhea; vaginal postpartum stasis abdominal pain; sore throat carbuncle.

[0046] 苏木,活血祛瘀,消肿定痛。 [0046] hematoxylin, stasis, swelling and pain. 如妇人血滞经闭,痛经,产后瘀阻心腹痛,产后血晕,痈肿,跌打损伤,破伤风。 The woman blood stagnation amenorrhea, dysmenorrhea, stasis cardiac postpartum pain, postpartum blood halo, carbuncles, bruises, tetanus. 心材入药,为清血剂,有祛痰、止痛、活血、散风之功效。 Heartwood medicine for blood clearance agent, has the effect of expectorants, analgesics, blood, scattered wind it. 近年来云南植物研究所从苏木的心材中提取一种苏木素,可用于生物制片的染色,效果不亚于进口的巴西苏木素。 In recent years, Yunnan Institute of Botany extracted from the heartwood of one of hematoxylin hematoxylin can be used to stain biological production, the effect of Brazilian imports as much as hematoxylin. 本种边材黄色微红,心材赭褐色,纹理斜,结构细,材质坚重,有光泽,干燥后少开裂,为细木工用材。 This species reddish yellow sapwood, heartwood ocher color, texture obliquely, fine structure, material re strong, shiny, and less cracking after drying for joinery timber. 1.《唐本草》:主破血,产后血胀闷欲死者。 1. "Tang Materia Medica": main Poxue, postpartum blood swelling nausea For deceased. 2.《本草拾遗》:主霍乱呕逆及人常呕吐,用水煎服之。 2. "Herbal Supplements": the main cholera vomiting and vomiting and people often use the decoction. 破血当以酒煮为良。 When expelling to Jiuzhu is good. 3.《海药本草》:主虚劳血癖气壅滞;产后恶露不安,腹中搅痛;及经络不通,男女中风,口噤不语。 3. "Sea herbal medicine": the main consumptive blood stasis gas addiction; lochia postpartum anxiety, stir belly pain; and meridian barrier, male and female stroke, lockjaw, without a word. 宜细研乳头香细末方寸匕,酒煎苏方去滓调服,立吐恶物瘥。 Fine grind fine papillary fragrance should Fangcun Bi, Jiu Jian Soviet transfer service to the dregs, Li spit evil, recover from illness. 4.《日华子本草》:治妇人血气心腹痛,月候不调及蓐劳。 4. "Japan Hanako Materia Medica": governance woman blood gas heart pain, not adjusted month-designate and mat workers. 排脓止痛,消痈肿扑损瘀血,女人失音,血噤,赤白痢并后分急痛。 Pus pain, carbuncle swollen flutter loss stasis, aphonia women, blood silent, and the sub-acute pain dysentery. 5.《医学启源》:《主治秘诀》云,发散表里风气。 5. "Medical Origins": "Indications secret," says divergence table atmosphere. 破死血。 Broken dead blood. 6.李果:破疮疡死血,产后败血。 6. Li Guo: sore broken dead blood, postpartum sepsis. 7.《医林纂要》:补心散瘀,除血分妄作之风热。 7. "medical Lin compile": bushing stasis, any rash Blood wind heat addition. [0047] 鹿衔草,能补虚、益肾、祛风除湿、活血调经、补肾强骨、止咳、止血。 [0047] Pyrolae, tonic, kidney, expelling wind and dampness, promoting blood circulation to regulate menstruation, kidney strong bone, cough, bleeding. 主治:主肾虚腰痛、风湿痹痛、筋骨痿软、新久咳嗽、吐血、衄血、崩漏、外伤出血。 Indications: primary kidney lower back pain, rheumatism, soft bones and muscles atrophy, new long cough, vomiting, epistaxis, uterine bleeding, traumatic bleeding. 1、《滇南本草》:“性温平,味辛。治筋骨疼痛,痰炎之症。”2、《植物名实图考》鹿衔草铺地生绿叶、紫背,面有白缕,略似蕺菜而微长,根亦紫。 1, "Southern Yunnan Materia Medica": ".. Warm, spicy governance muscles pain, inflammation of phlegm disease" 2, "plant name, map test" Pyrolae paving raw green leaves, purple back, face white thread , somewhat similar Houttuynia and slightly long, roots also purple. ”3、《中国药植志》:治虚痨,止咳。4、《重庆草药》:治虚弱痨病,咳嗽,白带。5、《四川常用中草药》:祛风除湿,止惊悸,盗汗。6、《陕西中草药》:补肾壮阳,调经活血,收敛止血。 "3," Chinese medicine plant Chi ": cure asthenia, cough .4," Chongqing herbs ": weak governance TB, cough, vaginal discharge .5," Sichuan Chinese Herbal Medicine ": Qufengchushi, only fright, night sweats .6, "Shaanxi Chinese herbal medicine": kidney impotence, menstruation blood, convergence bleeding.

[0048] 扦扦活,抗菌消炎、祛风除湿、活血止痛。 [0048] stick stick live, antibacterial anti-inflammatory, Qufengchushi Huoxuezhitong. 治肺炎、急性阑尾炎、急性胃肠炎、菌痢、风湿疼痛、跌打损伤、骨折。 Treatment of pneumonia, acute appendicitis, acute gastroenteritis, dysentery, rheumatic pain, bruises, fractures. 药用部位全草,味辛、苦,性平。 Medicinal parts of the whole plant, spicy, bitter, flat. 有抗菌消炎、清热解毒、祛风除湿、活血止痛、通经接骨等功效,用于治疗各种炎症性疾病、风湿关节痛、腰腿痛、疮疡肿毒肺炎、阑尾炎、急性蜂窝组织炎、肿瘤、跌打损伤、骨折等。 Antibacterial anti-inflammatory, detoxification, Qufengchushi Huoxuezhitong, pass through the bone and other effects, for the treatment of various inflammatory diseases, rheumatoid arthritis, back pain, sore swollen poison pneumonia, appendicitis, acute cellulitis, tumors, bruises, fractures. 近年用于治疗胰腺癌、胃癌、直肠癌、肝癌、食道癌等有较显著效果。 In recent years, for the treatment of pancreatic cancer, stomach cancer, colorectal cancer, liver cancer, esophageal cancer, which are more significant effect. 络石藤,具有祛风除湿,通络止痛,清热凉血,解毒消肿的功效,主治祛风通络,凉血消肿。 Network Ishido, Qufengchushi Tongluozhitong, heat, detoxification swelling effect, indications Qufengtongluo, cooling swelling. 用于风湿热痹,筋脉拘挛,腰膝酸痛,喉痹,痈肿,跌扑损伤。 For rheumatic fever weakness, tendons Spasm, waist and knee pain, pharyngitis, carbuncles, or flutter injury. 1.《纲目》:络石,气味平和,其功主筋骨关节风热痈肿,变白耐老,即医家鲜知用者,岂以其近贱而忽之耶。 1. "outline": jasminoides, mild odor, which wind power main joint bones heat carbuncle, whitening resistance to the old, i.e. by physicians who know little, but not at its base near the Lord suddenly. 服之当浸酒耳。 When soaked in wine service of the ear. 2.《得配本草》:络石,配射干、山桅,治毒气攻喉。 2. "was equipped with Materia Medica": complex stone, with Shegan, mountain masts, cure poison gas attack jets. 配参、苓、龙骨,治白浊已甚。 With ginseng, ling, keel, cure gonorrhea is already rather. 3.《要药分剂》:络石之功,专于舒筋活络。 3. "to the drug sub-agent": stone power network, designed to getting a vivid. 凡病人筋脉拘挛,不易伸屈者,服之无不获效,不可忽之也。 Where the patient tendons Spasm, not easy flexion who served surpasses been effective, can not be ignored also. 4.《本草正义》:络石气味,《本经》谓之苦温,盖以功能通经络活血而言之,故以为温。 4. "Herbal justice": jasminoides odor, the "after" that of bitter temperature, to cover the meridian function of promoting blood circulation purposes, it is that temperature. 然《本经》主治,纯是热症,则非温热可知,故《别录》改作微寒,而《御览》引李当之说,且以为大寒也。 However, "by" indications, purely fever, the non-warm seen, the "Do not record" changed slightly cold, and "Yu Lan 'lead when Lee said, and that is also the Big Chill. 此物善走经脉,通达肢节,《本经》主风热死肌,《别录》养肾,主腰髋痛,坚筋,利关节,皆即此义。 This was good to go meridians, accessible limb, "by" the main wind-heat dead muscle, "Do not record" Yang Shen, the main waist hip pain, muscle Kennedy, Lee joint, all that is this justice. 其治痈肿、喉舌肿,口干舌焦,皆苦寒泄降之功用也。 Its rule carbuncles, mouthpiece swollen, dry mouth and tongue coke, are also bitter cold drawdown of the function. 《别录》谓其除那气,则以邪热而言。 "Do not record" which claims that in addition to gas, places evil in terms of heat. 凡《本经》、《别录》邪气二字,所赅最广,其实各有所主,并非泛辞,读者当以意逆之,自能悟到,不可混作一例者。 Where the "Classic", "Do not record" evil word, the most widely used Gai, in fact, all have master, not the pan-speech reader as meaning against, the self can be realized, not one case of mixed cropping person. 惟大惊入腹四字,则不甚可解,当付阔疑。 But shocked Rufu four words, not very solvable, when doubt pay wide. 恭谓疗产后血结大良,盖以瘀露不通而言,苦泄破瘀,且善通络,是以主之。 CHRISTINE that big-junction postpartum blood treatment, in order to cover exposed barrier stasis, the bitter vent Po Yu, and good meridians, is Lord. 又谓主蝮蛇疮毒心闷,则清热泄降,固解毒之良药。 And that the main viper sore heart, nausea, heat the drawdown, solid medicine detoxification. 又谓刀斧伤疮,敷之立瘥,则又外治活血之神丹矣。 Also said that the ax hurt sore, apply the legislation recover from illness, but also the blood circulation outside the rule Shendan carry on. 藏器谓主一切风,即《本经》治风热死肌,《别录》利关节之义。 Tibet is the master of all that wind, that "by" wind-heat treatment dead muscle, "Do not record" joint profits of justice. 今用以舒节活络,宣通痹痛甚验。 Shu active for this festival, Xuan Tong Shen Tong Bi experience.

[0049] 海风藤,祛风湿,通经络,止痹痛。 [0049] haifengteng, rheumatism, Meridian, arthralgia stop. 用于风寒湿痹,肢节疼痛,筋脉拘挛,屈伸不利。 For wind musculoskeletal, limb pain, tendons Spasm, flexion and extension negative. 1.《本草再新》:行经络,和血脉,宽中理气,下湿除风,理腰脚气,治疝,安胎。 1. "New Materia Medica": the meridian line, and blood, wide in the gas, in addition to wet wind, Li waist beriberi, hernia treatment, tocolysis. 2.《浙江中药手册》:宣痹,化湿,通络舒筋。 2. "Zhejiang Chinese Medicine Handbook": numbness, dampness, Shujin meridians. 治腿膝痿痹,关节疼痛。 Treatment Tuixi paralysis, joint pain. 3.《中药志》:"辛,微温。〃《本草再新》:〃入心、肾二经。〃4.《别录》:主金疮痛。5.《开宝本草》:主风血,补衰老,起阳,强腰脚,除痹,变白,逐冷气,排风邪。亦煮汁服,亦浸酒服,冬月用之。6.《本草图经》:治腰痛。7.《滇南本草》:治寒湿痹伤筋,祛风,筋骨疼痛,利小便及茎中痛,热淋初起,利小便急速。8.《纲目》:煮汁服,治上气咳嗽。 3. "Medicine Chi": "Sim, tepid .〃" Materia Medica and then new ": 〃 into the heart, kidney two classics .〃4." Do not record ": the main gold sore .5" Kai Bao Materia Medica ": the main wind blood , up aging, from the sun, strong waist and feet, in addition to weakness, white, by air-conditioning, ventilation evil also served broth, also soaked in wine service, with the winter months .6 "the sketches by": lumbago .7 . "Southern Yunnan Materia medica": governance musculoskeletal injured tendons, chills, aching pain, diuresis and stems pain, hot shower early, rapid diuresis .8 "outline": broth clothes, gas cough on treatment.

[0050] 实施例1贴剂 [0050] Example 1 patch

本发明实施例提供了一种用于治疗膝骨关节炎的中药组合物,剂型为贴剂,其制备方法如下: Embodiment of the present invention provides a herbal composition for the treatment of osteoarthritis of the knee, is a patch formulation, prepared as follows:

a.称取当归1600g、桑寄生1800g、川芎1700g、羌活1500g、独活2900g、秦艽1500g、桂枝1500g、乳香1500g、木香1500g、桑枝1700g、仙鹤草1500g、杜仲1500g、熟地黄1400g、延胡索1400g、藏丁香1500g、鸡血藤1600g、牛膝2100g、三棱1600g、莪术1600g、附子1500g、仙茅1800g、巴戟天1700g、肥皂核1200g、丹参1500g、红花1700g、大黄1500g、三七1500g、苏木1500g、鹿衔草1600g、扦扦活1400g、络石藤1400g、海风藤1500g,加入10倍量85%的 a. Weigh Angelica 1600g, mistletoe 1800g, Chuanxiong 1700g, Notopterygium 1500g, independent living 2900g, Gentiana 1500g, Guizhi 1500g, frankincense 1500g, woody 1500g, mulberry 1700g, Agrimony 1500g, Eucommia 1500g, Rehmannia 1400g, Corydalis 1400g, possession of cloves 1500g, Millettia 1600g, Achyranthes 2100g, triangular 1600g, Curcuma 1600g, aconite 1500g, Curculigo 1800g, Morinda 1700g, soap nuclear 1200g, Salvia 1500g, safflower 1700g, rhubarb 1500g, thirty-seven 1500g, hematoxylin 1500g, Pyrolae 1600g, stick stick live 1400g, contact Ishido 1400g, haifengteng 1500g, was added 10-fold amount of 85%

乙醇中,加热回流提取2次,每次2小时,将提取液静置,得提取液I,药渣备用; Ethanol and heated to reflux for 2 times, 2 hours each time, the extract was allowed to stand to give the extract I, dregs standby;

b.将步骤a中乙醇提取过的药渣加水加热回流提取两次,每次2小时,合并提取液静置,得提取液2; . B The ethanol-extracted in step a dregs of water was heated at reflux extraction twice, 2 hours each time and the combined extracts allowed to stand to give 2 extract;

c.将提取液I和提取液2合并,抽入减压浓缩罐内,减压至0.06MPa,温度保持在70°C,浓缩至相对密度为1.20,温度至65°C的浸膏,加热浓缩至糊状,用酒、醋、蜂蜜调和即得贴剂。 c. Place extract I and 2 extracts were combined, concentrated under reduced pressure pumped into the tank under reduced pressure to 0.06MPa, the temperature was maintained at 70 ° C, concentrated to the relative density of 1.20 and a temperature of 65 ° C to extract heat was concentrated to a paste, wine, vinegar, honey harmonic to obtain a patch.

[0051] 实施例2胶囊剂 [0051] Embodiment Example 2 Capsules

本发明实施例提供了一种用于治疗膝骨关节炎的中药组合物,剂型为胶囊剂,其制备方法包括以下步骤:称取当归1200g、桑寄生2000g、川芎1200g、羌活1200g、独活4200g、秦艽1700g、桂枝1200g、乳香1700g、木香1900g、桑枝1400g、仙鹤草llOOg、杜仲1000g、熟地黄1000g、延胡索1800g、藏丁香1200g、鸡血藤1200g、牛膝1500g、三棱1200g、莪术1200g、附子1000g、仙茅1200g、巴戟天1200g、肥皂核1500g、丹参1000g、红花1200g、大黄1000g、三七1000g、苏木llOOg、鹿衔草1200g、扦扦活1800g、络石藤1700g、海风藤1200g,粉碎成粗粉后,再进一步粉碎,过100目~120目筛,使能通过筛的细粉量在达到30%,收集通过筛的细粉得细粉a ;再将不能通过120目筛的粗粉投入多功能提取罐提取两次,第一次加8倍量水煎煮2小时,第二次加7倍量水煎煮2小时,合并两次煎液,过滤得滤液,加热浓缩至糊状,放入烘箱80°C烘 Embodiment of the present invention provides a herbal composition for the treatment of osteoarthritis of the knee, the dosage form is a capsule, a preparation method comprising the steps of: weighing 1200 g of Angelica, mistletoe 2000g, 1200 g of Rhizoma Chuanxiong, 1200 g of Rhizoma, independent living 4200 g, Gentiana 1700g, Guizhi 1200g, frankincense 1700g, woody 1900g, mulberry 1400g, Agrimony llOOg, Eucommia 1000g, Rehmannia 1000g, Corydalis 1800g, possession of cloves 1200g, Millettia 1200g, Achyranthes 1500g, triangular 1200g, Curcuma 1200g, aconite 1000g, Curculigo 1200g, Morinda 1200g, soap nuclear 1500g, Salvia 1000g, safflower 1200g, rhubarb 1000g, thirty-seven 1000g, hematoxylin llOOg, Pyrolae 1200g, skewer stick in living 1800g, 1700g contact Ishido , 1200 g of rattan sea breeze, pulverized into a coarse powder, and further pulverized and sieved through 100 mesh to 120 mesh sieve, so that the amount of fines through a sieve of 30%, a fines collected through a fine sieve; then not multifunctional extracted by the coarse powder into a tank 120 mesh sieve was extracted twice, first adding 8 times the amount of boiling water for 2 hours and the second plus seven times the amount of boiling water for two hours, twice a decoction combined and filtered to give The filtrate was concentrated to a paste is heated, placed in drying oven at 80 ° C 干后冷却, 研磨成细粉b,将细粉a与细粉b混合后装入胶囊壳体中,即得胶囊剂。 After cooling the dried, ground into powder, b, b powder and a fine powder mixed in the encapsulated housing, i.e. to obtain capsules.

[0052] 实施例3片剂 [0052] Example 3 Tablets

本发明实施例提供了一种用于治疗膝骨关节炎的中药组合物,剂型为片剂,其制备方法包括以下步骤: Embodiment provides a herbal composition for the treatment of osteoarthritis of the knee of the present invention, the dosage form is a tablet, a preparation method comprising the steps of:

a、称取当归2000g、桑寄生1200g和川芎2200g,放入10倍量75%的乙醇中,加热回流提取2次,每次1.5小时,提取活性成份,将2次提取液合并静置,得提取液I ; a, angelica weighed 2000g, 1200g, and mistletoe Chuanxiong 2200 g, into 10 times the amount of 75% ethanol and heated at reflux for 2 times, each 1.5 hours, extract the active ingredient, the combined extracts allowed to stand for 2 to give extract I;

b、称取羌活1900g、独活1000g、秦艽llOOg、桂枝1900g、乳香1200g、木香1000g、桑枝2400g、仙鹤草2000g、杜仲1500g、熟地黄1200g、延胡索1200g、藏丁香1700g、鸡血藤1700g、牛膝1900g、三棱1800g、莪术1800g、附子1800g、仙茅2200g、巴戟天2200g、肥皂核1700g、丹参1700g、红花1700g、大黄1300g、三七1900g、苏木1300g、鹿衔草1600g、扦扦活1200g、络石藤llOOg、海风藤1800g,放入10倍量水中,加热回流提取3次,每次40分钟,将3次提取液合并静置,得提取液2 ; b, Notopterygium weighed 1900g, independent living 1000g, Gentiana llOOg, Guizhi 1900g, frankincense 1200g, woody 1000g, mulberry 2400g, Agrimony 2000g, Eucommia 1500g, Rehmannia 1200g, Corydalis 1200g, possession of cloves 1700g, 1700g Millettla , Achyranthes 1900g, triangular 1800g, Curcuma 1800g, aconite 1800g, Curculigo 2200g, Morinda 2200g, soap nuclear 1700g, Salvia 1700g, safflower 1700g, rhubarb 1300g, thirty-seven 1900g, hematoxylin 1300g, 1600g Pyrolae , 1200 g of live stick stick, contact Ishido llOOg, haifengteng 1800g, placed in 10-fold amount of water, heated to reflux and extracted three times, each time for 40 minutes, allowed to stand for 3 extracts were combined to give extract 2;

C、将提取液I和提取液2合并,减压回收乙醇并浓缩至药液浓度为0.5g生药/mL,抽滤后,滤液的相对密度为温度为20°C时1.08 ;将滤液经体积为10L的大孔吸附树脂柱洗脱两次,先用10倍树脂柱体积的去离子水或蒸馏水洗脱,再用5倍树脂柱体积的95%乙醇洗脱,收集乙醇洗脱液,去除溶剂,得到原料药,加入淀粉或糊精压片,得片剂。 C, the extract I and 2 were combined extract, and concentrated under reduced pressure to recover the ethanol solution concentration of 0.5g crude drug / mL, after filtration, the filtrate is the relative density of the temperature is 20 ° C 1.08; volume of the filtrate 10L elution macroporous adsorption resin column twice, first with 10 resin column volumes of deionized water or distilled water and eluted with 5 times the volume of resin column eluting with 95% ethanol, ethanol eluent were collected, removed The solvent to obtain the drug, added starch or dextrin tabletting to give tablets. 每片0.3g。 Each tablet 0.3g.

[0053] 药理药效学实验: [0053] Pharmacology pharmacodynamics of:

1、外用急性经皮毒性试验 1, the external acute dermal toxicity test

试验方法:依据卫生部《化妆品卫生规范》(2002)第二部分“急性经皮毒性试验”一次限量试验法,SD大鼠20只,雌雄各半,体重90g~180g,将本发明实施例1获得的贴剂,一次经皮涂抹5000mg/kg体重剂量,观察15天,未发现明显中毒症状、无死亡,动物大体解剖未见异常,判断该品对大鼠急性经皮毒性属实际无毒级。 Test Method: According to (2002) a second portion "cosmetic hygiene norms" MOH "acute dermal toxicity test" test method a limit, SD rats 20, male and female, weighing 90g ~ 180g, Example 1 of the present invention patches obtained, a transdermal applicator 5000mg / kg bodyweight, observed for 15 days, no obvious symptoms, no death, the animals were normal gross anatomy, the product is determined nontoxic rat acute dermal toxicity genus .

[0054] 2、外用急性皮肤刺激试验 [0054] 2, the external acute skin irritation test

试验方法:该品依据卫生部《化妆品卫生规范》(2002)第二部分“皮肤刺激性/腐蚀性试验”中6.3节,日本大耳白兔雄性4只,体重2kg~3kg,取本实施例1的贴剂0.5g直接涂抹在动物左侧皮肤上(另一侧作为对照),采用封闭试验,敷用时间4小时,试验结束后用温水冲洗残留受试物,于除去受试物后lh、24h、48h和72h分别观察动物受试区和对照区的皮肤反应,最高积分均值为“0”,判断该品对动物皮肤无刺激性。 Test Method: The product according to (2002) a second portion "cosmetic hygiene norms" MOH "skin irritation / corrosion test" 6.3, male Japanese white rabbits four, weighing 2kg ~ 3kg, the present embodiment takes patch 0.5g 1 is directly applied on the skin of the animal on the left side (the other side as a control), using a closed test-bonding time of 4 hours, the test end of the test the residue was rinsed with warm water, the test substance was removed after lh , 24h, 48h and 72h animal skin reactions were observed in the test area and control area, the maximum integral average is "0", which is determined without any irritation to the skin of the animal.

[0055] 3、内服急性毒性实验 [0055] 3, Oral acute toxicity test

应用NIH小鼠40只,SPF级,雌雄各半,体重16~20g,进行急性毒性试验。 Application of 40 NIH mice, the SPF level, male and female, weighing 16 ~ 20g, acute toxicity test. 小鼠随机分为两组,每组20只,即对照组和给药组,实验前禁食12小时;将本发明的实施例3制备的片剂溶解在水中,(浓度为6.58g生药/ml,最高浓度)灌胃,灌胃容积为5ml/kg (即单次给药剂量为32.9生药/kg),对照组给予等量生理盐水,一天给药2次,给药间隔时间6小时,给药后连续观察14天,并记录小鼠的毒性反应及死亡数。 Mice were divided into two groups of 20, i.e., control group and the administration group were fasted 12 hours before the experiment; the tablets prepared in Example 3 of the embodiment of the present invention is dissolved in water (concentration 6.58g of crude drug / ml, the highest concentration) intragastric gavage volume of 5ml / kg (i.e., a single dose of 32.9 crude drug / kg), control group was given normal saline, administered twice a day dosing interval for 6 hours. observed for 14 consecutive days after administration, and toxicity in mice and the number of deaths recorded. 实验结果表明:与对照组比较,给药后小鼠未见明显差异,实验连续观察14天,小鼠全身状况、饮食、饮水、体重增长均正常。 The results showed that: compared with the control group, no significant differences in mice after administration, consecutive experiments observed for 14 days, general condition, food and water, the mice were normal weight gain. 小鼠口服灌胃本发明的片剂LD50>32.9生药/kg,每日最大给药量为65.8生药/kg/日。 Mice fed LD50 oral tablets according to the present invention> 32.9 crude drug / kg, the maximum daily dose of 65.8 crude drug / kg / day. 本发明的中药临床用药量为4.4g生药/日/人,成人体重以60KG计,平均用药剂量为0.073g生药/kg/日。 An amount of medicine for the clinical use of the present invention is 4.4g crude drug / day / person, adult body weight 60KG meter, an average dose of crude drug 0.073g / kg / day. 按体重计:小鼠(平均体重以20g计)口服灌胃本发明的中药的耐受量为临床用量的901倍。 According to the weight: the mice (average body weight of 20g basis) by oral gavage tolerance of the medicine of the present invention is 901 times the clinical dose. 因此本发明的中药麻醉药物急性毒性低,临床用药安全。 Thus medicine anesthetics low acute toxicity of the present invention, the clinical drug safety.

[0056] 4.内服长期毒性试验: [0056] 4. Long-term oral toxicity test:

将本发明实施例2的胶囊剂对小鼠按7.81、18.34和40.1lg生药/kg连续用药12周(1.0ml/100g体重,每天2次)及停药4周后,结果表明:本发明中药制剂对大鼠的毛发、行为、大小便、体重、脏器重量、血象、肝肾功能、血糖、血脂等指标均无明显影响,脏器肉眼没有发现异样变化和组织学检查结果表明,用药12周及停药4周后,大鼠各脏器均无明显改变。 Example 2 Capsules of the embodiment of the present invention on mice by 7.81,18.34 and 40.1lg crude drug / kg continuously for 12 weeks (1.0ml / 100g of body weight, 2 times daily) and withdrawal four weeks, the results showed that: The traditional Chinese medicine hair preparations, behavior, urine, body weight, organ weight, blood, liver and kidney function, blood glucose, blood lipids in rats no significant effect, visually found no organ abnormalities and histology change results showed after 12 weeks and four weeks after withdrawal, no significant changes in rat organs. 说明本发明中药制剂对大鼠长期用药后毒性小,停药后也没有异样反应,应用安全。 Description of the traditional Chinese medicine preparation of the present invention is less toxic in rats after long-term treatment, no abnormal reaction after treatment, application security.

[0057] 临床资料1、资料与方法 [0057] The clinical data 1, Materials and Methods

1.1 一般资料:选择2011年9月-2012年8月期间,诊治的膝骨关节炎的患者共360例,其中男178例,女182例,40-50岁患者34例,51-60岁共92例,61-70岁共108例,70岁以上126例。 1.1 General Information: Select September 2011 - August 2012 period, the diagnosis and treatment of patients with osteoarthritis of the knee of a total of 360 cases, 178 cases were male, female 182 cases, 34 cases of patients 40-50 years old, 51-60 years old were 92 cases, 108 cases were 61-70 years old, 126 cases over 70 years old. 随机分成三组,治疗组1-3,每组120例。 Were randomly divided into three groups, the treatment group 1-3 120 patients in each group. 三组患者在年龄、性别、病情轻重方面比较差异无统计学意义,并根据病情的轻重门诊治疗。 Three groups of patients showed no significant difference in age, sex, severity aspects, outpatient treatment and the severity of the condition of patients.

[0058] 1.2诊断标准: [0058] 1.2 Diagnostic criteria:

采用美国风湿病学院(ACR)制定的膝关节标准:有膝痛及该膝X相示有骨骜,是伴有下述任一条者: Knee using American College of Rheumatology criteria (ACR) developed: there knee and the knee bone Ao shows the X-phase, is accompanied by any one of the following:

a、年龄兰40岁; a, Portland 40 years of age;

b、受累膝僵硬<30min ; b, stiff knee involvement <30min;

C、有骨摩擦音。 C, bone fricative.

[0059] 1.3疗效评定标准: [0059] 1.3 The evaluation criteria:

临床治愈:膝关节疼痛消失,关节活动自如,恢复正常生活及工作能力; Clinical cure: knee pain, joint freedom of movement, return to normal life and ability to work;

显效:膝关节疼痛明显减轻,关节活动稍有受限,能维持正常生活及工作;有效:膝关节疼痛减轻,关节活动有所改善,下蹲、起立、上下楼能坚持一定时间; Markedly: significantly reduced knee pain, joint activities slightly limited, to maintain the normal life and work; effective: to alleviate knee pain, joint activity has improved, squat, stand up, down the stairs to adhere to a certain time;

无效:治疗无效果。 Invalid: no therapeutic effect.

[0060] 1.4治疗组1-3,分别使用本发明实施例1-3的不同制剂的中药组合物进行治疗: (O治疗组1:120例患者经诊断患有膝骨关节炎,使用本发明实施例1的贴剂进行治 [0060] 1.4 treatment group 1-3, respectively, using traditional Chinese medicine composition of different formulations of Examples 1-3 of the present invention is the treatment of: (1 O treatment group: 120 patients diagnosed with osteoarthritis of the knee, the use of the present invention the patch of Example 1 treatment

疗,将贴剂敷于患处,贴药之处,需事先洗净,用保鲜膜或医用胶带固定贴剂,5h后揭下,每日1-2次,7天为一疗程,连续使用5-10个疗程。 Treatment, the affected area spreads patch, paste of the drug, to be washed in advance, or a medical tape with plastic wrap secured patch, peeled off after 5h, 1-2 times a day, seven days a course of treatment, continuous use 5 -10 courses. 停药I周后复诊,69例患者治疗效果为临床治愈,28例患者治疗效果显效,15例患者治疗效果有效,8例患者治疗无效。 Weeks after stopping referral I, 69 patients for the treatment of clinical cure, treatment of 28 patients were cured, effective treatment of 15 patients, 8 patients therapy. 治疗期间没有发现药物带来的其他副作用,随访半年,临床治愈患者均没有任何复发的症状。 Found no other side effects during treatment drugs brought up six months, the patients were clinically cured without any recurrence of symptoms.

[0061] (2)治疗组2:120例患者经诊断患有膝骨关节炎,使用本发明实施例2胶囊剂进行治疗,每日3次,一次0.4g, 7天为一疗程,连续使用5-10个疗程。 [0061] (2) 2 treatment groups: 120 patients diagnosed with osteoarthritis of the knee, the present invention is used in Example 2 were treated capsules, 3 times a day, once 0.4g, 7 days for treatment, continuous use 5-10 courses. 停药I周后复诊,67例患者治疗效果为临床治愈,25例患者治疗效果显效,19例患者治疗效果有效,9例患者治疗无效。 I weeks after stopping referral, 67 patients for the treatment of clinical cure, treatment of 25 patients were cured, effective treatment of 19 patients, 9 patients treatment ineffective. 治疗期间没有发现药物带来的其他副作用,随访半年,临床治愈患者均没有任何复发的症状。 Found no other side effects during treatment drugs brought up six months, the patients were clinically cured without any recurrence of symptoms.

[0062] (3)治疗组3:120例患者经诊断患有膝骨关节炎,使用本发明实施例3片剂进行治疗,每日3次,一次2-3片,7天为一疗程,连续使用5-10个疗程。 [0062] (3) Treatment Group 3: 120 patients diagnosed with osteoarthritis of the knee, using the embodiment of the present invention for the treatment of 3 tablets, 3 times a day, 2-3 tablets every time seven days for treatment, 5-10 courses of continuous use. 停药I周后复诊,65例患者治疗效果为临床治愈,27例患者治疗效果显效,17例患者治疗效果有效,11例患者治疗无效。 Weeks after stopping referral I, 65 patients for the treatment of clinical cure, treatment of 27 patients were cured, effective treatment of 17 patients, 11 patients therapy. 治疗期间没有发现药物带来的其他副作用,随访半年,临床治愈患者均没有任何复发的症状。 Found no other side effects during treatment drugs brought up six months, the patients were clinically cured without any recurrence of symptoms.

[0063] 2、具体病例 [0063] 2, particular case

病例1:孙某,男,73岁,多年膝痛及该膝X相示有骨骜。 Case 1: Sohn, male, 73 years old, the years of knee pain and knee X-phase bone shows Ao. 经具体检查确诊为膝骨关节炎,使用实施例1的贴剂进行治疗,使用时,将贴剂敷于患处,贴药之处,需事先洗净,用保鲜膜或医用胶带固定贴剂。 DETAILED was diagnosed with osteoarthritis of the knee, using the embodiment of the patch of Example 1 were treated, in use, spreads the affected area patch, paste of the drug, to be washed in advance, or a medical tape with plastic wrap secured patch. 5h后揭下,每日2次,7天为一疗程,连续使用8个疗程。 After 5h peeled off, 2 times a day, seven days a course of treatment, be used for eight courses. 停药I周后复诊,膝关节疼痛消失,关节活动自如,恢复正常生活及工作能力,治疗期间没有发现药物带来的其他副作用,随访半年,患者没有任何复发的症状。 I weeks after stopping referral, knee pain, joint freedom of movement, return to normal life and ability to work, and no other side effects caused by drugs during treatment, follow-up six months, the patient has no recurrence of symptoms.

[0064] 病例2:张某,女,65岁,多年膝痛及该膝X相示有骨骜,受累膝僵硬<30min ;有骨摩擦音,经具体检查确诊为膝骨关节炎。 [0064] Case 2: Zhang, female, 65 years old, over the knee and the knee bone Ao shows the X-phase, rigid knee involvement <30min; bone fricative, by specifically diagnosed with osteoarthritis of the knee. 使用实施例2的胶囊剂进行治疗,每日3次,一次 Use Example 2 Capsules were treated 3 times a day, once

0.4g,7天为一疗程,连续使用8个疗程。 0.4g, 7 days for treatment, used for eight courses. 停药I周后复诊,膝关节疼痛明显减轻,关节活动稍有受限,能维持正常生活及工作,治疗期间没有发现药物带来的其他副作用,随访半年,患者没有任何复发的症状。 I weeks after stopping referral, significantly reduced knee pain, joint activities slightly limited, to maintain the normal life and work, and no other side effects caused by drugs during treatment, follow-up six months, the patient has no recurrence of symptoms.

[0065] 病例3:李某,男,60岁,多年膝痛及该膝X相示有骨骜,受累膝僵硬<30min ;有骨摩擦音,经具体检查确诊为膝骨关节炎。 [0065] Case 3: Lee, male, 60 years old, over the knee and the knee bone Ao shows the X-phase, rigid knee involvement <30min; bone fricative, by specifically diagnosed with osteoarthritis of the knee. 使用实施例3的片剂,每日3次,一次2片,7天为一疗程,连续使用8个疗程。 Example 3 tablets, 3 times a day, once a two, seven days a course of treatment, be used for eight courses. 停药I周后复诊,膝关节疼痛明显减轻,关节活动稍有受限,能维持正常生活及工作,治疗期间没有发现药物带来的其他副作用,随访半年,患者没有任何复发的症状。 I weeks after stopping referral, significantly reduced knee pain, joint activities slightly limited, to maintain the normal life and work, and no other side effects caused by drugs during treatment, follow-up six months, the patient has no recurrence of symptoms.

[0066] 以上所述仅为本发明的较佳实施例,并不用以限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。 [0066] The foregoing is only preferred embodiments of the present invention, not intended to limit the present invention within the spirit and principle of the present invention, any modification, equivalent replacement, or improvement, it should be included in the present within the scope of the invention.

Claims (10)

1.一种用于治疗膝骨关节炎的中药组合物,其特征在于,所述中药组合物中各种原料药材的重量份数比为:当归10~20份,桑寄生10~25份,川芎10~25份,羌活10~20份,独活10~50份,秦艽10~20份,桂枝10~20份,乳香10~20份,木香10~20份,桑枝10~25份,仙鹤草10~20份,杜仲10~20份,熟地黄10~20份,延胡索10~20份,藏丁香10-20份,鸡血藤10~20份,牛膝10~25份,三棱10~20份,莪术10~20份,附子10~20份,仙茅10~25份,巴戟天10~25份,肥皂核10-20份,丹参10~20份,红花10~25份,大黄10~20份,三七10~20份,苏木10~20份,鹿衔草10~20份,扦扦活10~20份,络石藤10~20份和海风藤10~20份。 An herbal composition for treating osteoarthritis of the knee, wherein said herbal composition of various ingredients by weight ratio of the raw material: 10 to 20 parts angelica, mistletoe 10 to 25 parts, 10 to 25 parts Chuanxiong, Rhizoma 10 to 20 parts, from 10 to 50 parts by living alone, Gentiana 10 to 20 parts, 10 to 20 parts by Gui, frankincense 10 to 20 parts, 10 to 20 parts woody, 10 to 25 parts by mulberry , agrimony 10 to 20 parts, 10 to 20 parts Eucommia, Rehmannia 10-20 parts, 10-20 parts fumaric, clove possession 10-20 parts, 10-20 parts Millettia, Achyranthes 10 to 25 parts, tris rib 10 to 20 parts, 10 to 20 parts Curcuma, aconite 10 to 20 parts, from 10 to 25 parts Curculigo, Morinda 10 to 25 parts, 10-20 parts by nuclear soap, 10 to 20 parts of Salvia miltiorrhiza, safflower ~ 10 parts 25, 10 to 20 parts rhubarb, Panax 10 to 20 parts, 10 to 20 parts by hematoxylin, Pyrolae 10 to 20 parts, 10 to 20 stick stick live parts, contact Ishido 10 to 20 parts and 10 haifengteng to 20 parts.
2.根据权利要求1所述的用于治疗膝骨关节炎的中药组合物,其特征在于,所述中药组合物中各原料药材的重量份数比为:当归12~18份,桑寄生15~22份,川芎12~23份,羌活12~17份,独活17~42份,秦艽12~18份,桂枝12~18份,乳香12~17份,木香11~19份,桑枝14~21份,仙鹤草11~18份,杜仲10~20份,熟地黄10~20份,延胡索10~18份,藏丁香13-17份,鸡血藤12~20份,牛膝15~25份,三棱12~20份,莪术12~20份,附子10~20份,仙茅10~25份,巴戟天10~25份,肥皂核12-17份,丹参10~20份,红花10~25份,大黄10~20份,三七10~20份,苏木10~20份,鹿衔草10~20份,扦扦活10~18份,络石藤13~17份和海风藤12~18份。 The traditional Chinese medicine composition for treating osteoarthritis of the knee according to claim 1, wherein said herbal parts by weight of the composition ratio of each raw herbs: Angelica 12 to 18 parts, 15 Loranthaceae to 22 parts, from 12 to 23 parts by Chuanxiong, Rhizoma 12 to 17 parts, 17 to 42 parts by independent living, Gentiana 12 to 18 parts, 12 to 18 parts by Gui, frankincense 12 to 17 parts, 11 to 19 parts woody, mulberry 14 to 21 parts, 11 to 18 parts by agrimony, Eucommia 10 to 20 parts, Rehmannia glutinosa 10 to 20 parts, 10 to 18 parts fumarate, clove hidden parts 13-17, Millettia 12 to 20 parts, Achyranthes 15 ~ parts 25, 12 to 20 parts by triangular, Curcuma 12 to 20 parts, aconite 10 to 20 parts, from 10 to 25 parts Curculigo, Morinda 10 to 25 parts, 12-17 parts by nuclear soap, 10 to 20 parts of Salvia miltiorrhiza, 10 to 25 parts of safflower, rhubarb 10 to 20 parts, March 10 to 20 parts, 10 to 20 parts by hematoxylin, Pyrolae 10 to 20 parts, 10 to 18 living skewer stick parts, contact Ishido 13 to 17 parts and 12 to 18 parts by haifengteng.
3.根据权利要求1或2所述的用于治疗膝骨关节炎的中药组合物,其特征在于,所述中药组合物中各原料药材的重量份数比为:当归16份,桑寄生18份,川芎17份,羌活15份,独活29份,秦艽15份,桂枝15份,乳香15份,木香15份,桑枝17份,仙鹤草15份,杜仲15份,熟地黄14份,延胡索14份,藏丁香15份,鸡血藤16份,牛膝21份,三棱16份,莪术16份,附子15份,仙茅18份,巴戟天17份,肥皂核15份,丹参15份,红花17份,大黄15份,三七15份,苏木15份,鹿衔草16份,扦扦活14份,络石藤14份和海风藤15份。 The traditional Chinese medicine composition for treating osteoarthritis of the knee of claim 1 or claim 2, wherein said herbal parts by weight of the composition ratio of each raw herbs: Angelica parts 16, 18 Loranthaceae copies, Chuanxiong 17 parts, 15 parts Notopterygium, independent living 29 parts, 15 parts Gentiana, Guizhi 15 parts, 15 parts of frankincense, woody 15 parts, 17 parts of mulberry, Agrimony 15 parts, 15 parts of Eucommia, Rehmannia 14 parts fumarate 14 parts, 15 parts hidden clove, Millettia 16 parts, 21 parts of Achyranthes, triangular parts 16, 16 parts of Curcuma, tuber parts 15, 18 parts of Curculigo, Morinda 17 parts, 15 parts soap nucleus, Salvia 15 parts, 17 parts of safflower, 15 parts rhubarb, Panax 15 parts, 15 parts by hematoxylin, Pyrolae 16 parts, 14 parts stick stick live, contact Ishido 14 parts and 15 parts haifengteng.
4.一种如权利要求1-3任意一项所述的用于治疗膝骨关节炎的中药组合物的制备方法,其特征在于,所述中药组合物的剂型为贴剂,所述制备方法包括以下步骤: a.取上述重量份数比的原料药材放入乙醇中加热回流提取2次,得提取液I ;` b.再将上述乙醇提取过的药渣,加水加热回流提取I次,得提取液2 ; c.将提取液I和提取液2合并,浓缩,得到药物浸膏;加热浓缩调制。 The preparation of claim 4. A method as claimed in any of 1-3 treatment of knee osteoarthritis preparing Chinese medicinal composition according to claim, wherein the dosage form composition is a patch medicine, comprising the steps of: a ratio of parts by weight to take the above raw herbs into ethanol was heated at reflux for 2 times to obtain extract I; `b then ethanol-extracted dregs above, extraction with water was heated at reflux for I times. the extract was obtained 2;. C and the extract I 2 extracts were combined and concentrated to give the pharmaceutical extract; modulation concentrated by heating.
5.根据权利要求4所述的用于治疗膝骨关节炎的中药组合物的制备方法,其特征在于,所述步骤a中,按所述重量份数比称取的原料药材加入10倍量60-85%的乙醇中,加热回流提取2次,每次I~2小时,将提取液静置,得提取液I,药渣备用。 The method of preparing the herbal composition for the treatment of knee osteoarthritis according to claim 4, wherein said step a, the parts by weight ratio of the weighed raw medicine amount 10 times 60-85% of ethanol, heated to reflux for 2 times, each I ~ 2 hours, the extract was allowed to stand to give the extract I, dregs standby.
6.根据权利要求4所述的用于治疗膝骨关节炎的中药组合物的制备方法,其特征在于,所述步骤b中,将步骤a中乙醇提取过的药渣加水加热回流提取两次,每次I~2小时,合并提取液静置,得提取液2。 The method of preparing the herbal composition for the treatment of knee osteoarthritis according to claim 4, wherein said step b, the alcohol extract in step a treated water was heated at reflux for dregs extracted twice , every I ~ 2 hours, and the combined extracts allowed to stand to give 2 extract.
7.根据权利要求4所述的用于治疗膝骨关节炎的中药组合物的制备方法,其特征在于,所述步骤c中,将提取液I和提取液2合并,抽入减压浓缩罐内,减压至0.03-0.08MPa,温度保持在60-80°C,浓缩至温度为60°C _70°C时相对密度为1.20,加热浓缩至糊状,用酒、醋、蜂蜜调和即得贴剂。 7. A method of preparing Chinese medicine composition for treating osteoarthritis of the knee according to claim 4, characterized in that said step (c), and the extract I 2 extracts were combined, concentrated under reduced pressure pumped into the tank the pressure was reduced to 0.03-0.08MPa, maintaining the temperature at 60-80 ° C, a temperature and concentrated to a relative density of 1.20 60 ° C _70 ° C, was heated and concentrated to a paste, wine, vinegar, honey obtain reconcile patch.
8.—种如权利要求1-3任意一项所述的用于治疗膝骨关节炎的中药组合物的制备方法,其特征在于,所述中药组合物的剂型为胶囊剂,所述制备方法包括以下步骤:按照重量份数比称取所有原料药材,粉碎成粗粉,再进一步粉碎,过100目~120目筛,使能通过筛的细粉量达到30%,收集通过筛的细粉得细粉a;再将不能通过100目~120目筛的粗粉投入多功能提取罐提取两次,第一次加5-10倍量水煎煮1-2小时,第二次加4-8倍量水煎煮1-2小时,合并两次煎液,过滤得滤液,加热浓缩至糊状,放入烘箱80°C烘干后冷却,研磨成细粉b,将细粉a与细粉b混合后装入胶囊壳体中,即得胶囊剂。 8.- The preparation method of any of claims 1-3 as seed preparation method for treating osteoarthritis of the knee of a herbal composition according to, wherein said herbal formulation composition is a capsule, comprising the steps of: in a weight ratio of weighed parts all herbs material, crushed into coarse powder, and further pulverized and sieved through 100 mesh to 120 mesh sieve, so that the amount of fines through the sieve 30%, fine powder passed through the sieve was collected to obtain powder a; then not through a 100 mesh ~ 120 mesh sieve coarse powder into the multifunction extraction tank and extracted twice, first adding 5-10 times the amount of boiling water for 1-2 hours, the second increase 4- 8 times the amount of boiling water for 1-2 hours, the two decoctions were combined and filtered to give the filtrate was concentrated to a paste is heated, placed in an oven at 80 ° C after drying was cooled, ground to a fine powder B, the fine powder with a b mixed powder was charged in a capsule shell, to obtain capsules.
9.一种如权利要求1-3任意一项所述的用于治疗膝骨关节炎的中药组合物的制备方法,其特征在于,所述中药组合物的剂型为片剂,所述制备方法包括以下步骤: a、按照重量份数比称取当归、桑寄生和川芎,放入10倍量75%的乙醇中,加热回流提取2次,每次I~2小时,提取活性成份,将2次提取液合并静置,得提取液I ; b、按照重量份数比称取剩余原料药材,放入10倍量水中,加热回流提取3次,每次30分钟~I小时,将3次提取液合并静置,得提取液2 ; C、将提取液I和提取液2合并,减压回收乙醇并浓缩至药液浓度为0.5g生药/mL,抽滤后,得20°C时相对密度为1.08的滤液;将滤液经体积为IOL的大孔吸附树脂柱洗脱两次,先用10倍树脂柱体积的去离子水或蒸馏水洗脱,再用5倍树脂柱体积的95%乙醇洗脱,收集乙醇洗脱液,去除溶剂,得到原料药,加入淀粉或糊精压片, A method for the preparation of any of claims 1-3 Preparation methods of treating osteoarthritis of the knee of a herbal composition according to, wherein said herbal composition is a dosage form of a tablet, comprising the steps of: a, a weight ratio of weighed parts Angelica and Ligusticum Loranthaceae, into 10 times the amount of 75% ethanol and heated at reflux for 2 times, each I ~ 2 hours, and extraction of the active ingredient, the 2 the combined extracts were left standing times to obtain extract I; b, parts a weight ratio of starting material remaining ingredients were weighed, placed in 10-fold amount of water, heated to reflux and extracted three times, 30 minutes each ~ I h, extracted 3 times the combined solution was allowed to stand to give 2 extract; C, and the extract I 2 extracts were combined, and concentrated under reduced pressure to recover the ethanol solution concentration of 0.5g crude drug / mL, after filtration, to obtain the relative density 20 ° C the filtrate was 1.08; the filtrate volume of the adsorption IOL macroporous resin column was eluted twice, first with 10 resin column volumes of deionized water or distilled water and eluted with 5 times the resin column volumes 95% ethanol wash off, ethanol eluent were collected, the solvent was removed to give the drug, added starch or dextrin tableting, 片剂。 Tablets.
10.根据权利要求1-3任意一项所述的用于治疗膝骨关节炎的中药组合物,其特征在于,所述中药组合物的剂型为:片剂、糖衣片剂、薄膜衣片剂、肠溶衣片剂、胶囊剂、硬胶囊齐ϋ、软胶囊剂、口服液、口含剂、颗粒剂、冲剂、蜜丸剂、散剂、丹剂、溶液剂、注射剂、栓剂、硬膏剂、糖浆剂、散剂、灌肠剂或`贴剂。 According to any one of claims 1-3 for the treatment of knee osteoarthritis Chinese medicine composition, characterized in that the herbal composition of dosage forms: tablets, sugar-coated tablets, film-coated tablets , enteric coated tablets, capsules, hard capsules together ϋ, soft capsules, oral, buccal tablets, granules, powder, pill, powder, Dan, solutions, injections, suppositories, plasters, syrup , powders, enemas or `patch.
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CN104223469A (en) * 2014-08-27 2014-12-24 茹晖 Waistcoat with self-defense and health-care functions
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CN105168439A (en) * 2015-08-25 2015-12-23 孙太辉 Drug for treating senescent arthritis and preparation method thereof
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CN105617282A (en) * 2016-03-11 2016-06-01 孙勇博 Externally-applied medicinal wine
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CN102698085A (en) * 2012-06-26 2012-10-03 张士虎 Chinese medicinal plaster for treating arthritis

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CN104223469A (en) * 2014-08-27 2014-12-24 茹晖 Waistcoat with self-defense and health-care functions
CN104922612A (en) * 2015-07-21 2015-09-23 山东省文登整骨医院 Traditional Chinese medicine used for treating gonitis
CN105168439A (en) * 2015-08-25 2015-12-23 孙太辉 Drug for treating senescent arthritis and preparation method thereof
CN105233041A (en) * 2015-10-21 2016-01-13 刘松霞 Traditional Chinese medicine lotion for treating knee osteoarthritis and nursing method of knee osteoarthritis
CN105617282A (en) * 2016-03-11 2016-06-01 孙勇博 Externally-applied medicinal wine
CN105726809A (en) * 2016-03-28 2016-07-06 张艳娟 Medicine composition for treating primary hyperuricemia
CN105770774A (en) * 2016-05-11 2016-07-20 慕荣 Traditional Chinese medicinal composition for treating knee osteoarthritis and preparation method thereof
CN105853792A (en) * 2016-05-11 2016-08-17 柳宝栋 Externally-applied traditional Chinese medicinal preparation for treating gonitis and preparation method of externally-applied traditional Chinese medicinal preparation

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