CN103520654A

CN103520654A - Chinese medicine composition for treating knee osteoarthritis and preparation method of Chinese medicine composition

Info

Publication number: CN103520654A
Application number: CN201310508609.5A
Authority: CN
Inventors: 梁轶聪
Original assignee: Individual
Current assignee: Qingdao Central Hospital
Priority date: 2013-10-25
Filing date: 2013-10-25
Publication date: 2014-01-22
Anticipated expiration: 2033-10-25
Also published as: CN103520654B

Abstract

The invention discloses a Chinese medicine composition for treating knee osteoarthritis. The Chinese medicine composition is prepared from the following active medicine materials: angelica sinensis, loranthus parasiticus, ligusticum chuanxiong, notopterygium root, radix angelicae pubescentis, gentiana macrophylla, cassia twig, frankincense, elecampane, ramulus mori, agrimonia pilosa, eucommia ulmoides, prepared rehmannia root, corydalis tuber, syringa tibetica, millettia dielsiana, the root of bidentate achyranthes, rhizoma sparganii, curcuma zedoaria, monkshood, rhizoma curculiginis, morinda officinalis, seed of gymnocladus chinensis baill, the root of red-rooted salvia, carthamus tinctorius, rheum officinale, pseudo-ginseng, caesalpinia sappan, pyrola, sambucuspwilliamsiip, Chinese starjasmine stem and kadsura pepper stem. The Chinese medicine composition for treating knee osteoarthritis mainly aims at tonifying kidney, strengthening bone, activating meridians to stop pain, activating blood to disperse stasis, dispelling the wind and coldness, and is a novel medicine which is simple and convenient in preparation process, small in toxic and side effect, convenient to administrate, easy to manufacture and low in cost.

Description

A kind of Chinese medicine composition that is used for the treatment of knee osteoarthritis and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicine composition for the treatment of knee osteoarthritis and preparation method thereof.

Background technology

Osteoarthritis is a kind of chronic joint disease, and its main change is degeneration and the insecondary hyperosteogeny of articular cartilage face.Main manifestations is arthralgia and movable dumb, and x-ray performance joint space narrows down, and subchondral bone matter is fine and close, and bone trabecula fracture, has sclerosis and cystis degeneration.There is lip sample hypertrophy at edge, joint.Later stage epiphysis distortion, articular surface is uneven.Intraarticular cartilage peels off, and the cracked joint that enters of sclerotin forms articular mobile corpus.Osteoarthritis is named again degenerative osteoarthritis, and actual not inflammation, is mainly degeneration, belongs to the aging of joint premature aging, particularly articular cartilage.Osteoarthritis is representing the aging in joint, therefore be referred to as senile arthritis.(1) understanding of the traditional Chinese medical science to knee osteoarthritis name of disease

Knee osteoarthritis belongs to the category of motherland's medical science " rheumatism involving the bone ", " lumbago and skelalgia "." Standards of Diagnosis and Treatment " are said: " upper and lower lower limb is thin, and only knee joint is large, and shape is as crane knee joint " pointed out the clinical symptoms of " arthroncus of knee " and the knee enlargement in gonarthritis later stage, and tibia atrophy is more similar." Plain Questions lunge joint opinion " said: " sick at bone, unable to raise the limbs due to heaviness of the bones, aching pain in the bone marrow, extremely, name is said rheumatism involving the bone to cold." " Plain Questions air pocket opinion " say: " and accumulated cold staying in the body, Rong Wei does not occupy, volume meat contracting muscle, rib elbow must not be stretched, and interior is rheumatism involving the bone, is outward meciless." " prescriptions worth thousand gold " point out that rheumatism involving the bone further develops and can involve in kidney, becomes " bone exhaustion ".The discussion that " Plain Questions numbness opinion " is detailed pathogenic factor and the clinical manifestation of arthromyodynia, according to disease, from 4 o'clock, be subject to evil position to propose the concept of " muscular rheumatism ", " BI-syndrome related to skin ", " BI-syndrome involved the blood vessels ", " rheumatism involving the bone ", according to describing specific symptom, " numbness is that bone is heavy; blood is puckery and do not flow to be arteries and veins; being that muscle is bent does not stretch; be that meat is meciless, be Pi Zehan." point out " sick at bone, unable to raise the limbs due to heaviness of the bones, aching pain in the bone marrow, extremely, name is said rheumatism involving the bone to cold "; Jing-Yue Complete Works cloud: " lid numbness person close also, and the QI and blood of take is closed by evil, must not pass through and disease also ", " card of migratory arthralgia, on the whole because empty person is many, only QI and blood is not filled, therefore wind and cold is entered it, only YIN pathogen is detained, therefore passages through which vital energy circulates is unfavorable for it." relation that " void ", " heresy ", " stasis of blood " and primary disease produce proposed thus; Qing Dynasty's Wang Qingren errors in Medicine Corrected proposes congestion and causes numbness theory; " the former purport of ancient Chinese medical classics " points out " wind, cold, wet three gas are mixed extremely, combined into numbness ... take the winter meets this person as rheumatism involving the bone ... therefore rheumatism involving the bone endlessly "; " Compendium of medicine " cloud: " the wet person of winter sense wind and cold, is rheumatism involving the bone, endlessly enters for a long time kidney "; " General Treatise on the Cause and Symptoms of Diseases asthenia time " pointed out: " hold the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, main waist foot, its gas Rong Run bone marrow, the present suffers from a deficiency of the kidney and has a cold, therefore make the knee joint also cold "; " General Treatise on the Cause and Symptoms of Diseases " said: " asthenia blood loss marrow, therefore muscle and tendon injury bone for liver governing tendons and store blood, the kidney generating marrow and dominating bone." Chao Yuanfang (550-630 A.D.) thinks that the main cause that causes arthromyodynia is that the empty sense of body is evil, is on the basis of suffering from a deficiency of the kidney, the damp that is affected by the cold with the passing of time due to; " Zhang Shi doctor is logical " also points out that the etiology and pathogenesis of " gonalgia " is relevant with " without having not because of liver person who suffer from deficiency of kidney Yang, void wind and cold gas is attacked it ".Caused by liver and kidney deficiency is described, asthenia of essence and blood is the basic reason of knee osteoarthritis morbidity, and the invasion and attack of wet three gas of wind and cold are the marks of knee osteoarthritis morbidity." Huatuo god side " thinks that " rheumatism involving the bone is that appetite does not save and hinders in kidney yet simultaneously." illustrate that the generation of knee osteoarthritis and diet also have relation.Clinical diagnosis: 1. there is knee soft tissue injury, memoryless but most people did not arouse attention at that time.2. the gonalgia and send out stiffly, morning, WA was more obvious, after activity, alleviated, and movablely increased the weight of again remission after having a rest when many.3. later stage pain continues, and joint motion is obviously limited, atrophy of quadriceps femoris, and, even there is deformity and articular mobile corpus in hydrarthrosis.4. when knee joint is bent and stretched activity, can lay one's hand on and friction sound.Knee joint just, side position X photo, show that patella, condyle of femur, tibial plateau joint margins are lip sample hyperosteogeny, tibia spinous process of tibia comes to a point, joint space narrows down, subchondral bone matter is fine and close, sometimes visible articular mobile corpus.Therapeutic Principle: primary disease treatment treatment by Chinese herbs knee osteoarthritis, mainly with invigorating the kidney and strengthening the bones, removing obstruction in the collateral to relieve pain, blood circulation promoting and blood stasis dispelling, expelling wind and cold, coordinates the method treatments such as acupuncture, laser, external treatment.

Modern medicine thinks that the detailed cause of disease is not yet clear at present, is clearly now the destruction that many factors causes articular cartilage.Normal relevant with following factors: 1. to damage: the articular cartilage damage causing as reasons such as intra-articular fracture, meniscus injury, human bones dislocations.2. excessively bear a heavy burden: by obesity or the inside and outside talipes varus of knee joint, cause articular surface and excessively bear a heavy burden.3. infection or inflammation cause articular cartilage damage.4. subchondral bone is downright bad, as articular mobile corpus, causes articular cartilage face to damage.

(1) the treatment of knee osteoarthritis publicizes diseases prevention knowledge, Saving cortilage: first will allow patient be familiar with to some extent this disease, physical training is incremental, prevents joint hyperkinesia and heavy burden, avoids joint mechanical injuries.When serious, should brake or Gypsum Fibrosum is fixed, in case lopsided.Lose weight, use handle, walking stick to alleviate the joint load of getting involved.With the relevant person of occupation, should be assigned a new job.Carry out the exercise of relevant muscle group, can keep and improve joint motion, to strengthen the stability in joint.(2) physiotherapy: thermotherapy, hydrotherapy, infrared ray, ultrashort wave, electricity irritation etc. all can strengthen local blood circulation, alleviate muscular tone, the symptom such as ease the pain.Traction treatment is better to cervical spondylotic radiculopathy patient effect, can relaxed muscle, and alleviating pain, and can prevent that the tissue that nerve root is adjacent from forming adhesion, but must under specialist instructs, carry out.(3) massage and Chinese medicine: the massage of motherland's medical science, acupuncture and moxibustion therapy are having positive effect aspect ameliorate osteoarthritis symptom; The agent of existing Chinese medicine note can promoting blood circulation and stopping pain, and sometimes also there is good effect, but have side effect, and easily recurrence.

Summary of the invention

Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, new drug with low cost.The present invention adopts the Chinese crude drug of different properties, has carried out science compatibility, can reach desirable therapeutic effect, and safety, and toxic and side effects is little, and preparation is simple, the focus of going directly, and healing time is short, after curing, is difficult for recurrence.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of knee osteoarthritis, in described Chinese medicine composition, the ratio of weight and number of various raw medicinal materials is: 10～20 parts of Radix Angelicae Sinensis, 10～25 parts of Herba Taxillis, 10～25 parts of Rhizoma Chuanxiongs, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～50 parts of Radix Angelicae Pubescentiss, 10～20 parts of Radix Gentianae Macrophyllae, 10～20 parts of Ramulus Cinnamomi, 10～20 parts of Olibanums, 10～20 parts of the Radix Aucklandiae, 10～25 parts of Ramulus Moris, 10～20 parts of Herba Agrimoniaes, 10～20 parts of the Cortexs Eucommiae, 10～20 parts of Radix Rehmanniae Preparata, 10～20 parts of Rhizoma Corydalis, hide Flos Caryophylli 10-20 part, 10～20 parts of Caulis Spatholobis, 10～25 parts of Radix Achyranthis Bidentataes, 10～20 parts of Rhizoma Sparganii, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Aconiti Lateralis Preparatas, 10～25 parts of Rhizoma Curculiginises, 10～25 parts of Radix Morindae Officinaliss, Semen Gymnocladi Chinensis 10-20 part, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～25 parts, Flos Carthami, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Notoginseng, 10～20 parts of Lignum Sappans, 10～20 parts of Herba Pyrolaes, 10～20 parts of pubescent angelica roots, 10～20 parts of Caulis Trachelospermis, 10～20 parts of Caulis Piperis Kadsuraes.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is preferably: 12～18 parts of Radix Angelicae Sinensis, 15～22 parts of Herba Taxillis, 12～23 parts of Rhizoma Chuanxiongs, 12～17 parts of Rhizoma Et Radix Notopterygiis, 17～42 parts of Radix Angelicae Pubescentiss, 12～18 parts of Radix Gentianae Macrophyllae, 12～18 parts of Ramulus Cinnamomi, 12～17 parts of Olibanums, 11～19 parts of the Radix Aucklandiae, 14～21 parts of Ramulus Moris, 11～18 parts of Herba Agrimoniaes, 10～20 parts of the Cortexs Eucommiae, 10～20 parts of Radix Rehmanniae Preparata, 10～18 parts of Rhizoma Corydalis, hide Flos Caryophylli 13-17 part, 12～20 parts of Caulis Spatholobis, 15～25 parts of Radix Achyranthis Bidentataes, 12～20 parts of Rhizoma Sparganii, 12～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Aconiti Lateralis Preparatas, 10～25 parts of Rhizoma Curculiginises, 10～25 parts of Radix Morindae Officinaliss, Semen Gymnocladi Chinensis 12-17 part, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～25 parts, Flos Carthami, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Notoginseng, 10～20 parts of Lignum Sappans, 10～20 parts of Herba Pyrolaes, 10～18 parts of pubescent angelica roots, 13～17 parts of Caulis Trachelospermis, 12～18 parts of Caulis Piperis Kadsuraes.

In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can also be preferably: 16 parts of Radix Angelicae Sinensis, 18 parts of Herba Taxillis, 17 parts of Rhizoma Chuanxiongs, 15 parts of Rhizoma Et Radix Notopterygiis, 29 parts of Radix Angelicae Pubescentiss, 15 parts of Radix Gentianae Macrophyllae, 15 parts of Ramulus Cinnamomi, 15 parts of Olibanums, 15 parts of the Radix Aucklandiae, 17 parts of Ramulus Moris, 15 parts of Herba Agrimoniaes, 15 parts of the Cortexs Eucommiae, 14 parts of Radix Rehmanniae Preparata, 14 parts of Rhizoma Corydalis, hide 15 parts of Flos Caryophyllis, 16 parts of Caulis Spatholobis, 21 parts of Radix Achyranthis Bidentataes, 16 parts of Rhizoma Sparganii, 16 parts of Rhizoma Curcumae, 15 parts of Radix Aconiti Lateralis Preparatas, 18 parts of Rhizoma Curculiginises, 17 parts of Radix Morindae Officinaliss, 15 parts of Semen Gymnocladi Chinensiss, 15 parts of Radix Salviae Miltiorrhizaes, 17 parts, Flos Carthami, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Notoginseng, 15 parts of Lignum Sappans, 16 parts of Herba Pyrolaes, 14 parts of pubescent angelica roots, 14 parts of Caulis Trachelospermis, 15 parts of Caulis Piperis Kadsuraes.

In order better to realize foregoing invention object, the present invention also provides a kind of preparation method that is used for the treatment of the Chinese medicine composition of knee osteoarthritis, and the dosage form of described Chinese medicine composition is patch, and described preparation method comprises the following steps:

A. get the raw medicinal material of above-mentioned ratio of weight and number and put into ethanol heating and refluxing extraction 2 times, obtain extracting solution 1;

B. again by the raw medicinal material of above-mentioned ethanol extraction, add water heating and refluxing extraction 1 time, obtain extracting solution 2;

C. extracting solution 1 and extracting solution 2 are merged, concentrated, obtain drug extract; The concentrated modulation of heating.

Wherein, in described step a, the raw medicinal material taking by described ratio of weight and number adds in the ethanol of 10 times of amount 60-85%, heating and refluxing extraction 2 times, and each 1～2 hour, extracting solution is standing, obtain extracting solution 1, medicinal residues are standby.

In described step b, the medicinal residues that in step a, ethanol extraction is crossed are added to water heating and refluxing extraction twice, each 1～2 hour, merge extractive liquid, was standing, obtained extracting solution 2.

In described step c, extracting solution 1 and extracting solution 2 are merged, in suction concentrating under reduced pressure tank, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and when being concentrated into temperature and being 60 ℃-70 ℃, relative density is 1.20, heating is concentrated into pasty state, with wine, vinegar, Mel, is in harmonious proportion and obtains patch.

The present invention also provides a kind of preparation method that is used for the treatment of the Chinese medicine composition of knee osteoarthritis, the dosage form of described Chinese medicine composition is capsule, described preparation method comprises the following steps: according to ratio of weight and number, take all raw medicinal materials, be ground into coarse powder, further pulverize again, cross 100 order～120 mesh sieves, the fine powder amount that enable pass is sieved is reaching 30%, and the fine powder of collecting by sieve obtains fine powder a; Can not by the coarse powder of 120 mesh sieves, drop into multi-function extractor again extracts twice, add for the first time 5-10 times of water gaging and decoct 1-2 hour, add for the second time 4-8 times of water gaging and decoct 1-2 hour, merge decocting liquid twice, filter to get filtrate, heating is concentrated into pasty state, put into after 80 ℃ of oven dry of baking oven cooling, grind to form fine powder b, after fine powder a is mixed with fine powder b, incapsulate in housing, obtain capsule.

The present invention provides again a kind of preparation method that is used for the treatment of the Chinese medicine composition of knee osteoarthritis, and the dosage form of described Chinese medicine composition is tablet, and described preparation method comprises the following steps:

A, according to ratio of weight and number, take Radix Angelicae Sinensis, Herba Taxilli and Rhizoma Chuanxiong, put into the ethanol of 10 times of amounts 75%, heating and refluxing extraction 2 times, each 1～2 hour, extract active ingredient, 2 extracting solution are merged standing, obtain extracting solution 1;

B, according to ratio of weight and number, take except by other raw medicinal materials of Radix Angelicae Sinensis, Herba Taxilli and Rhizoma Chuanxiong, put into 10 times of water gagings, heating and refluxing extraction 3 times, each 30 minutes～1 hour, 3 extracting solution are merged standing, obtain extracting solution 2;

C, extracting solution 1 and extracting solution 2 merged, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is that temperature is while being 20 ℃ 1.08; The macroporous adsorptive resins eluting twice that is 10L through volume by filtrate, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain crude drug, add starch or dextrin tabletting, obtain tablet.

The dosage form of described Chinese medicine composition is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder, enema or patch.

Chinese medicine composition of the present invention has treatment by Chinese herbs knee osteoarthritis and mainly take invigorating the kidney and strengthening the bones, removing obstruction in the collateral to relieve pain, blood circulation promoting and blood stasis dispelling, expelling wind and cold etc. as main; And processing technology is easy, the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost.The present invention adopts the Chinese crude drug of different properties, has carried out science compatibility, can reach desirable therapeutic effect, and safety, and toxic and side effects is little, and preparation is simple, the focus of going directly, and healing time is short, after curing, is difficult for recurrence.

The specific embodiment

Osteoarthritis is more common in middle-aged and elderly people, it is characterized in that degeneration or the destruction of knee cartilage, the sclerosis of subchondral bone matter, and edge, joint hyperosteogeny forms.Patient's main manifestations is the gonalgia, strand lock, dysfunction, and severe patient also can be with arthroncus, peripheral edema, amyotrophy etc." Plain Questions numbness opinion ": " wet three gas of wind and cold are mixed extremely, combined into numbness also." " Plain Questions lunge joint opinion ": " and sick at bone, unable to raise the limbs due to heaviness of the bones, aching pain in the bone marrow, extremely, name is said rheumatism involving the bone to cold." " the logical gonalgia of Zhang Shi doctor ": " and the internal organs that knee joint is muscle, gonalgia is without having not because of liver person who suffer from deficiency of kidney Yang, and void wind and cold dampness is attacked it." all illustrated the pathogen and pathology of tcm of primary disease." pathogenesis is that long-term chronic damages always, insufficiency of vital energy and blood, caused by liver and kidney deficiency; In addition wind-cold damp pathogen is taken advantage of a weak point in opponent's defence and is attacked, the meridians of being detained, and qi and blood stagnation, with the passing of time stagnation of QI-blood is not all right; Yang deficiency cold coagulation, muscles and bones loses Wen Xi, forms for a long time rheumatism involving the bone.

External application of Chinese medicine is one of the most frequently used clinically external treatment of Chinese medicine, " Handbook of Prescriptions for Emergencies " of Jin Daige flood work, the Thousand Golden Prescriptions of the Tang Dynasty Sun Simiao, supplement to Thousand Golden Prescriptions, in " medical secrets of official " of Wang Taozhu and the Compendium of Material Medica of Ming Dynasty's Li Shizhen (1518-1593 A.D.), contained therapy has all related to external application of Chinese medicine.Because meridians have interior genus internal organs, outer network podomere, link up the exterior and the interior, run through upper and lower effect, thus not only can treat local patholoic change, but also can reach by external application the object for the treatment of systemic disease.Medicine by) stimulation at local acupuncture point, through skin, penetrate, excite through feeling pulse gas, promote internal organs QI-blood circulation, play therapeutical effect; Skin is thinner, neural, blood vessel is abundanter, therefore umbilical part has compared with absorbability by force and rapidly, there are good impression and conduction function, when the medicine with suitable treats in umbilical part, all local teleneuron be can stimulate, internal organs and tissue physiology's activity and pathological change improved, the immunity of enhancing body and resistance against diseases.The treatment of external application of Chinese medicine thermal-arrest, medication, moxibustion are in one, play the effect of invigorating the spleen to arrest diarrhea, avoided oral simultaneously and injected bring inconvenient and painful, the head of a family and infant are easy to accept, and lasting medicine, avoid the first pass effect of liver and interference and the Degradation of gastrointestinal factor, reduced individual variation, rapid-action, strong drug action, without wound, no pain, easy to use.

The merit that in side, Chinese angelica blood supplementing is invigorated blood circulation, Rhizoma Chuanxiong is invigorated blood circulation.Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae be inducing diuresis to remove edema through dispeling the wind; Flos Carthami enters network and the knee blood stasis that goes to dispel through Radix Achyranthis Bidentatae tying-in; The medical materials such as the Cortex Eucommiae, Radix Rehmanniae Preparata, Rhizoma Corydalis, Caulis Spatholobi, Radix Achyranthis Bidentatae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Aconiti Lateralis Preparata, scorpion venom, Rhizoma Curculiginis, Radix Morindae Officinalis, Radix Salviae Miltiorrhizae and Flos Carthami.With Radix Rehmanniae Preparata, Rhizoma Drynariae, Radix Achyranthis Bidentatae, Fructus Psoraleae etc. can liver and kidney tonifying, bone and muscle strengthening; Caulis Spatholobi, Hirudo promoting blood circulation and breaking stagnation for side; Side's Radix Rehmanniae Preparata, can strengthen patient's immunity, strengthens the activity of glutathion peroxidase, and resisting blood coagulation reduces lipid peroxide, can effectively improve the symptom of the deficiency of YIN; Side's Radix Aconiti Lateralis Preparata, has antiinflammatory, central and periphery analgesia, irritation cell secreting leukocytes mesonium-2, the effects such as enhancing and adjusting body's immunity; Side's Radix Salviae Miltiorrhizae, can enhancing human body immunity power, has blood fat reducing, atherosclerosis and improve the effects such as microcirculation; Side's Rhizoma Corydalis, has the effect of analgesia and tranquilizing soporific; Side, with Rhizoma Curculiginis, has antiinflammatory, the effects such as the hypertrophy of promotion macrophage and phagocytic activity; Side's Radix Morindae Officinalis, has antiinflammatory, strengthens the effects such as anti-fatigue ability; Scorpio, the flat acrid in the mouth of its property, the effect of tool wind dispelling dredging collateral for side.All medicines have share the effects such as kidney-yang nourishing, liver and kidney tonifying, blood circulation and removing stasis, warm podomere, gasified water are wet.Radix Et Rhizoma Rhei, pseudo-ginseng blood-circulation-invigovating, removing heat from blood.Herba Agrimoniae promoting blood circulation and cooling blood.Herba Taxilli, Radix Gentianae Macrophyllae, Ramulus Mori etc. have the effect of promoting blood circulation by removing wind.The Ramulus Cinnamomi warming the meridian that activates yang.Lignum Sappan, Herba Pyrolae, pubescent angelica root, Caulis Trachelospermi, Caulis Piperis Kadsurae has dispelling wind and removing obstruction in the collateral.

Radix Angelicae Sinensis, the dry root that these product are umbelliferae angelica.Autumn end excavates, and removes fibrous root and silt, after moisture slightly evaporates, is bundled into wisp, and upper canopy, with pyrotechnics smoke-dried beancurd slowly.Radix Angelicae Sinensis root is slightly cylindrical, and root upper end claims " returning head ", and main root claims " returning body " or " very little body ".Supporting root claims " Radix Angelicae Sinensis " or " returning lower limb ", all claim " Radix Angelicae Sinensis ".Radix Angelicae Sinensis can be enriched blood, can invigorate blood circulation again, and general designation and blood; Radix Angelicae Sinensis body is enriched blood, Radix Angelicae Sinensis removing blood stasis sweet in the mouth; Pungent; Bitter; Warm in nature.Return liver; The heart; Spleen channel.Hematonic; Emmenagogue; Analgesic.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.

Herba Taxilli, invigorating the liver and kidney; Bone and muscle strengthening; Wind-damp dispelling; Antiabortive.Main soreness of waist and knee joint; A little less than muscles and bones flaccidity; Limbs are hemiplegia; Rheumatic arthralgia; Head is wrong dizzy; Frequent fetal movement, metrostaxis.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, and metrorrhagia warp is many, blood leaking in gestation, frequent fetal movement; Hypertension.1. " herbal classic ": main lumbago, children's's stiffback, carbuncle, antiabortive, fill skin, hard, tooth, long man.2. " not Lu ": main incised wound, go numbness, woman's metrorrhagia, internal injury is not enough, puerperal remaining disease, lower milk.3. " property of medicine opinion ": can make tire firm, the pregnant leakage blood in main bosom is more than.4. " Japan hanako materia medica ": help muscles and bones, beneficial blood vessels are " the southern regions of the Yunnan Province book on Chinese herbal medicine " 5.: raw Sophora japonica L. person, cures mainly large intestine hematochezia, hemorrhoidal hamorrhage band blood, anal fistula.Raw mulberry person, controls bones and muscles pain, walks grain, anemofrigid-damp arthralgia.Pericarpium Zanthoxyli tree person, controls taste cold, the nauseating regurgitation of food from the stomach of vomiting; Again with controlling syphilitic skin lesions poison, first deficiency and coldness or metrorrhagia under married woman.6. " book on Chinese herbal medicine covers bamboo fish trap ": loose skin infection, chases after rheumatism, but stiffback lumbago.7. " the SHENGCAO property of medicine is standby to be wanted ": the heat that disappears, nourishing, chases after wind.The heat radiation of nourishing blood, makes tea-drinking, relaxing muscles and tendons and activating QI and blood in the collateral.8. " beautiful Chinese catalpa medicine solution ": control dysentery.

Radix Gentianae Macrophyllae, for rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, infantile malnutrition heating.1. " detailed outline ": " Radix Gentianae Macrophyllae, hands and feet caused by paralysis, jaundice, the disease palpus of excessive thirst, get it and go sun bright also damp and hot.Sun is bright to be had wetly, and health ache dysphoria with smothery sensation, has Re Ze to feed hectic fever hectic fever due to YIN-deficiency." 2. " Bencao Jingshu ": " Radix Gentianae Macrophyllae, hardship can be let out, and pungent energy is loose, tepor energy tonneau, thus main cold and heat pathogen, cold-damp migratory arthralgia, arthrodynia of the extremities, lower water, diuresis.Performance expelling wind and removing dampness, therefore that " not Lu " treats wind is new for a long time without asking, and the whole body contraction is anxious.Can dampness heat radiation tie, therefore " solar corona " controls hectic fever due to YIN-deficiency and infantile malnutrition with fever; Zhen Quan controls alcoholic jaundice alcoholic intoxication; Element is except positive bright rheumatism, and hands and feet caused by paralysis, and hemorrhoidal hamorrhage rushes down blood, and flourish muscle nourishes blood; Good Gu expels the heat-evil, beneficial courage.Salty with its dehumidifying eliminating stagnation, the merit of bowel relieving stomach also." 3. " book on Chinese herbal medicine is levied and wanted ": " Radix Gentianae Macrophyllae, is longer than and nourishes blood, therefore the relaxing muscles and tendons of bringing down a fever.Control wind and first control blood, blood wind is from going out, therefore it is for a long time new without asking to treat wind.Enter stomach damp eliminating heat, therefore normal urination and jaundice are more also."

Rhizoma Chuanxiong, blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Textual criticism: come from Materia Medica of Decoction and cure mainly: medicine first choice for the treatment of headache.Menoxenia; Amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; Lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; Ulcer sores." herbal classic ": main apoplexy enters brain headache, arthralgia due to cold, clonic spasm of the muscle emergency, gold wound, married woman's blood closes loss of fecundity." not Lu ": except cold moving in brain, on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold.TAO Hong-Jing: tooth root bleeder, is recovered more than containing." property of medicine opinion ": control waist foot weak, hemiplegia, main afterbirth does not go out, and controls cold type of pain in abdomen." Japan hanako materia medica ": control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, and strengthening bone and muscle, adjusts many arteries and veins, and broken crux stagnated blood, supports fresh blood, puts on flesh, and serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, scrofula wart is superfluous, skin ulcer scabies, and evacuation of pus repercussive blood." medicine origin ": enrich blood, control headache due to deficiency of blood.Wang Haogu: search irritability, tonifying liver blood, profit liver is dry, mends wind empty." detailed outline ": dampness, antidiarrheal dysentery, activating QI to alleviate the depression.Rhizome of chuanxiong Qiong, in blood gas medicine also, liver bitter anxious with pungent benefit it, therefore blood deficiency person should it; Pungent to fall apart it, therefore stagnation of QI person should it." left biography " sayed wheat Qu, brought up poor imperial wetting, and controls stomach ailment.Give and control dairrhea caused by pathogenic damp, often add two tastes, it should be as sound.Dysentery is led to and the more than person of pain, is the cloudy stagnation of QI of losing, and in medicine, adding rhizome of chuanxiong is assistant, and gas promoting the circulation of blood is adjusted, and its disease stops immediately.Amplification on Canon of Materia Medica: rhizome of chuanxiong Qiong, moderns are used at most, women's head-ornaments wind can not fault also, so must help it with his medicine.

Rhizoma Et Radix Notopterygii, acrid in the mouth; Bitter; Warm in nature.1. " property of medicine opinion ": bitter in the mouth is pungent, nontoxic.2. " medicine origin ": " curing mainly secret wanting " cloud: warm in nature, acrid in the mouth.3. Materia Medica of Decoction: feeble QI temperature, bitter but sweet flavor is flat.Enter bladder, kidney channel.1. " pearl sac ": bladder meridian.Hands sun small intestinal is Materia Medica of Decoction 2.: the sufficient sun, JUE YIN meridian.3. " book on Chinese herbal medicine covers bamboo fish trap ": hands, the sufficient sun, few cloudy, the JUE YIN meridian of foot.Loose exterior cold; Wind-damp dispelling; Profit joint; Pain relieving.Main affection of exogenous wind-cold; Have a headache lossless; Mimeograph cold-damp numbness; Edema due to wind pathogen edema; Sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.The cold expelling that induces sweat, expelling wind and dampness, pain relieving.

Radix Angelicae Pubescentis, expelling wind and dampness; Dispersing cold for relieving pain.For anemofrigid-damp arthralgia; Lumbocrural pain; Few cloudy volt wind headache, headache toothache.1. anemofrigid-damp arthralgia.The pungent loose hardship of these product is dry, and the fragrant temperature of gas is logical, and merit be apt to Eradicates rheumatism, and stopping numbness pain is dispelling the wind and dampness pathogens arthralgia pain principal agent, and no matter new of a specified duration the arthromyodynia due to all wind-cold damp pathogens is, all can apply; Because it is main, enter kidney channel, property is kind descending, especially with waist knee joint, the lower limb joints of foot pain subordinate cold-damp person of portion, is advisable.Control the anemofrigid-damp arthralgia of the damp that is affected by the cold, muscle, back, brothers' pain, normal and Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Achyranthis Bidentatae are equal to use, as Radix Angelicae Pubescentis soup (" the young new book of living "); If with compatibilities such as Herba Taxilli, the Cortex Eucommiae, Radix Ginsengs, can control arthromyodynia with the passing of time weakened body resistance, soreness of the waist and knees, joint joint stuffiness person, as Radix Angelicae Pubescentis et Herba Taxilli Decoction (" prescriptions worth thousand gold ").2. wind and cold is held wet exterior syndrome under the arm.The pungent loose temperature of these product is logical bitter dry, can dispersing wind and cold wet and induce sweat, and controls the headache that affection of exogenous wind-cold holds under the arm due to wet nose heave, pain to the greatest extent all over the body, and polygamy Rhizoma Et Radix Notopterygii, Rhizoma Ligustici, Radix Saposhnikoviae etc., as Decoction of Notopterygium for Rheumatism (" differentiation on endogenous ").3. SHAO YIN headache.These product are apt to search volt wind into kidney channel, match with Herba Asari, Rhizoma Chuanxiong etc., can control wind and disturb kidney channel, and volt and the SHAO YIN headache that do not go out, as Radix Angelicae Pubescentis asarum decoction (" disease because of arteries and veins control ").

Ramulus Cinnamomi, pungent; Sweet; Warm in nature.1. " medicine origin ": gas heat, acrid-sweet flavor.2. " herbal classic is met former ": pungent, sweet, tepor, nontoxic.Enter bladder, the heart, lung meridian.1. Materia Medica of Decoction: enter meridian of Foot-TAI YANG.2. " Thunder God is concocted property of medicine solution ": enter lung meridian.3. " medicineization justice ": enter liver, kidney, bladder three warps.4. " book on Chinese herbal medicine is looked for the truth ": enter flesh table, doublely enter the heart, liver.Cure mainly: expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea stomachache; Lump in the abdomen caking; The thoracic obstruction; Cardiopalmus; Dysuria.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention water-retention, edema, cardiopalmus, renal mass.Merit diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.

Olibanum, regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.1. " not Lu ": treat edema due to wind pathogen poison swollen, remove bad odor.Treat the urticaria poison of itching.2. supplement to the Herbal: treat deaf, apoplexy locked mouth, married woman's vim and vigour, can send out wine, manage air-cooledly, stop large intestine and let out Bleach, treat all skin ulcers and make internal diabetes.3. " Japan hanako materia medica ": stop cholera, cardiac and abdominal pain.Soft extracts pain relieving is put on flesh.4. " Zhenglei Bencao ": control sleeplessness.5. " pearl sac ": fixed all warps are pain.6. " detailed outline ": all poison of eliminating carbuncle cellulitis, the heart is protected in Tuoli, and the analgesic therapy of invigorating blood circulation, stretches muscle, controls married woman's difficult labour, injured.7. " Bencao Congxin ": control demented, stopping leak dysentery.8. " key medicine is divided agent ": dysentery with red and white feces more than person that suffers from abdominal pain, adds Olibanum invariably to imitate.

The Radix Aucklandiae, promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune.Main born of the same parents coerce distension foot; Abdominal distention; Tell and have loose bowels; Heavy after dysentery.For heavy after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, distension and fullness in the abdomen or the pain of anorexia 1. stagnation of QI in spleen and stomach, belch, nausea and vomiting.2. the abdominal distention uncomfortable in chest of turbid damp obstructing in middle-JIAO, indigestion and loss of appetite loose stool.3. phlegm-damp is stopped up the cough and asthma of lung.4. pathogen, wards off malicious epidemic disease temperature ghost, strong will, and main pouring is revealed.Take for a long time not dream awake horrible nightmare.(" herbal classic ") 5. sterilizes, and kills terrible smart thing, pyrexial malaria diseases due to noxious agents produced by various parasites, and the bad QI-insufficiency of gas, partially cold in flesh, the essence of priming.(" not Lu ") Ramulus Mori, enters Liver Channel.1. " must join book on Chinese herbal medicine ": enter meridian of Hand-TAI YIN.2. " book on Chinese herbal medicine is new again ": enter lung, kidney two warps.3. " book on Chinese herbal medicine brief points ": start with, meridian of Foot-TAI YIN.Wind-damp dispelling; The meridian dredging; Row aqueous vapor.Main air pain of dampness syndrome; Apoplexy and hemiplegia; Edema foot gas; Human body pruritus due to wind pathogen.Be used for takeing on arm, joint aches numbness.1. " Bencao Tujing ": treat all over body pruritus due to wind pathogen and be dried, beriberi pathogenic wind, spasm of the limbs, upper gas, feels dizzy, and lung qi is coughed, and helps digestion; Diuresis, holds concurrently and treats xerostomia.2. " book on Chinese herbal medicine covers bamboo fish trap ": profit is breathed heavily the contrary gas ， Xiao burning swelling poison carbuncle of coughing.3. " book on Chinese herbal medicine converges and says ": remove pathogenic wind spasm and pain.4. essentials of Matea Medica: sharp joint, promoting fluid production, row water dispels the wind.5. " beautiful Chinese catalpa medicine solution ": control apoplexy crooked, cough.6. " book on Chinese herbal medicine is new again ": strong lung qi, dampness, kidney nourishing water, stimulates the menstrual flow, cough-relieving relieving restlessness, reducing swelling and alleviating pain.7. " south of the Five Ridges gather medicinal herbs record ": the joint wind disease of boning, punish-old year the arthroncus of knee.8. " modern Practical Chinese medicinal ": twig and leaf are endured cream clothes, control hypertension, numb hand and foot.

Herba Agrimoniae, astringing to arrest bleeding, dysentery relieving, parasite killing.Be widely used in various hemorrhage cards, for example: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the cards such as wound hemorrhage.1. 《 Lv Cliff rock is herbal ": " leaf is controlled skin ulcer tinea." 2. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " and control married woman's menstruation or before or after, leucorrhea with red and white discharge, the cold stomachache of face, with the passing of time red white dysentery." 3. " the SHENGCAO property of medicine is standby to be wanted ": " reason traumatic injury wound, hemostasis, sore-toxin dispersing." 4. " BAICAO mirror ": " therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, reason all kinds of diseases and ailments, loose feeling of fullness; Traumatic injury is spitted blood, metrorrhagia, dysentery, discharging fresh blood stool." 5. " plant name figure examines ": " controls wind-phlegm lumbago." 6. " pseudo-medicated strip is distinguished ": " controls scrofula." 7. " modern Practical Chinese medicinal ": " is the agent of robustness astringing to arrest bleeding, has cardiotonic concurrently.Be applicable to pneumonopathy spitting of blood, enterorrhagia, gastric hemorrhage, gear division is hemorrhage, hemorrhoidal bleeding, the diseases such as liver abscess.“

The Cortex Eucommiae, the Cortex Eucommiae is warm in nature, and sweet in the mouth has invigorating the liver and kidney, strong waist knee joint, bone and muscle strengthening, antiabortive effect.The Cortex Eucommiae has regulating action in various degree to immune system, hormonal system, central nervous system, blood circulation and urinary system, the excited Pituitary Adrenal cortex system of Cortex Eucommiae energy, adrenal cortex reinforcing function.Modern study also finds, the Cortex Eucommiae has and Radix Codonopsis, immunological enhancement function that the Radix Astragali is the same.All these has confirmed that ancient Chinese has the discussion of " clothes are made light of one's life by commiting suicide resistance to old for a long time " about the Cortex Eucommiae.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, and vaginal bleeding during pregnancy is wanted to fall, frequent fetal movement, hypertension." beautiful Chinese catalpa medicine solution ": " liver and kidney tonifying, nourishing muscle and tendon bone go to joint wet excessive.Control soreness of waist and knee joint, the contracture of lower limb foot." Pharmacopoeia of the People's Republic of China (version was in 2010): " and invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For deficiency of the liver and kindey, soreness of waist and knee joint, muscles and bones is unable, have a dizzy spell, and blood leaking in gestation, frequent fetal movement." Cortex Eucommiae is famous and precious tonic herb, in its effective ingredient, except the medicinal ingredient that contains a large amount of known activity, also contains multiple nutrients material, nutrient substance is the important substance basis of eucommia health care effect.

Radix Rehmanniae Preparata, the yin nourishing of enriching blood, life essence-filling, marrow-benefitting.Apply all cards of 1. blood deficiency.The sweet Wen Zhirun of this product, nourishing YIN benefit essence, with hemopoietic, is the key medicine of the tonify deficiency that nourishes blood.Normal and Radix Angelicae Sinensis, the Radix Paeoniae Alba, the same use of Rhizoma Chuanxiong, treat blood deficiency and yellow complexion, dizzy, cardiopalmus, insomnia and menoxenia, metrorrhagia and metrostaxis etc., as SIWU TANG); If deficiency of heart-blood severe palpitation, can be with the sedative such as Radix Polygalae, Semen Ziziphi Spinosae with using; If the empty cold in blood of metrostaxis and hyperamization, few abdomen cold type of pain person, can with tonifying blood and arresting bleeding, the same use of dispelling cold by warming the meridian medicine such as Colla Corii Asini, Folium Artemisiae Argyi, as Ass-hide Glue and Argyi Leaf Decoction.2. all cards of the hepatic and renal YIN deficiency.This quality is moistened into kidney, kind nourishing kidney yin, and life essence-filling, marrow-benefitting, is the key medicine of tonifying kidney-yin.Ancients call it " large tonifying five ZANG-organs is Kidney-Yin ", " mending greatly true water ".Normal be equal to use with Rhizoma Dioscoreae, Fructus Corni, treat the hepatic and renal YIN deficiency, soreness of the waist and knees, seminal emission, night sweat, tinnitus, deafness and quench one's thirst etc., can invigorating the liver and kidney, and beneficial marrow, as LIUWEI DIHUANG WAN; Also can be equal to treatment deficiency of YIN osteopyrexia and fever, as dabuyin pill (" danxi's experiential therapy ") with the Rhizoma Anemarrhenae, Cortex Phellodendri, Carapax Et Plastrum Testudinis.This product benefiting essence-blood, black beard and hair, the compatibilities such as normal and Radix Polygoni Multiflori, Radix Achyranthis Bidentatae, Semen Cuscutae, control blood and essence asthenia early whitening of beard and hair, as Qibao Meiran Dan (" collection of prescriptions with notes "); This product vital essence replenishing and marrow benifiting, bone and muscle strengthening, also can join Carapax Et Plastrum Testudinis, Herba Cynomorii, Rhizoma Cibotii etc., treatment deficiency of the liver and kindey, and five kinds of growth retardation five kinds of flaccidity in infant, as Huqian Wan (" collection of prescriptions with notes ").In addition, Radix Rehmanniae Preparata charcoal can stop blooding, and can be used for the blood deficiency such as metrorrhagia and goes out blood disorder.

Rhizoma Corydalis, invigorates blood circulation; Dissipating blood stasis; Regulate the flow of vital energy; Pain relieving.The all pains of main trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.1. analgesic activity: Rhizoma Corydalis powder has analgesic activity, and its pain relieving is tired and is about 1/100 of opium; Rhizoma Corydalis total alkaloids, Corydaline, second element, ugly element, the last of the ten Heavenly stems, element all had analgesic activity, stronger with second element. and various dosage forms are strong with alcohol extractum processed and powder effect.2. calmness, stable, syngignoscism: tetrahydropalmatine has certain calmness, stable effect, and its levo form is novel central inhibitor, during larger dose, rabbit, Canis familiaris L., monkey is had to obvious syngignoscism.3. the impact on digestive system: dehydrogenation Corydaline has significant anti-Experimental Gastric Ulcer in Rats effect.

Hide Flos Caryophylli, micro-hardship; Puckery; Flat.Function cures mainly: bone and muscle strengthening; Inducing diuresis and reducing edema.Main lumbago due to renal deficiency; Nutritional edema; Eczema; Traumatic injury.

Caulis Spatholobi, relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation.Main numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea; Amenorrhea is enriched blood, invigorates blood circulation, and dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.Join Herba Leonuri, blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving; Join Rhizoma Atractylodis, regulating QI to expel dampness, ward off dirty go turbid; Join the Cortex Eucommiae, invigorating the kidney and strengthening the bones, inducing menstruation to relieve menalgia; Join Radix Angelicae Sinensis, enrich blood and invigorate blood circulation.1. menoxenia, dysmenorrhea, amenorrhea.This product is bitter and not dry, warm and not strong, promoting the circulation of blood dissipating blood stasis, and menstruction regulating and pain relieving, character is gentle, the blood tonification effect of simultaneously holding concurrently again, the menopathy of all married woman's blood stasis and blood deficiency all can be applied.Control menoxenia, dysmenorrhea, the amenorrhea of blood stasis, can compatibility Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Cyperi be equal to use; Control blood deficiency menoxenia, dysmenorrhea, amenorrhea, join Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba etc. medicinal.2. rheumatic arthralgia, numb hand and foot, quadriplegia and blood deficiency and yellow complexion.This product promoting the circulation of blood is nourished blood, and relaxing muscles and tendons and activating QI and blood in the collateral is not smooth for treating passages through which vital energy circulates, the common medicine of channels discord disease.As dispelling the wind and dampness pathogens arthralgia pain, numb limbs and tense tendons, can compatibility medicine for rheumatism, as medicines such as Radix Angelicae Pubescentis, Radix Clematidis, Herba Taxillis; Control apoplexy numb hand and foot, quadriplegia, Chang Peiwu benefiting QI for activating blood circulation dredging collateral medicine, as medicines such as the Radix Astragali, Radix Salviae Miltiorrhizae, Pheretimas; Numb limbs and tense tendons and the blood deficiency and yellow complexion of controlling not nourishing muscle and tendon of blood deficiency, the Radix Astragali of polygamy qi-replenishing and blood-enriching medicine, Radix Angelicae Sinensis etc. are medicinal.3. control radioactivity leukopenia: coordinate the medicine of other nourishing qi and bloods with using.

Radix Achyranthis Bidentatae, 1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": control furuncle, carbuncle, apply affected part.Also can have an abortion.With Carnis Sus domestica, simmer food, energy improving eyesight.2. " Chinese medicine shape sex experience differential method ": the effect of have diuresis, strong essence, stimulating the menstrual flow.Energy relaxing muscles and tendons to promote blood circulation, specially controls lumbocrural pain.3. " herbal classic ": main cold-damp flaccidity syndrome and arthralgia syndrome, spasm of the limbs, gonalgia can not be bent, and by vim and vigour, the fire of getting mildewed in warm conditions is rotten, induced abortion.4. " not Lu ": the middle weak breath of curing the wound, male kidney yin disappears, and old man loses excessive, and invigorating middle warmer is absolutely continuous, fills out bone marrow, and except pain and pain along the spinal column in brain, married woman's moon water is obstructed, blood agglomeration, benefit essence, Li Yin gas, only turns white.5. " property of medicine opinion ": control impotence, kidney tonifying, essence replenishing, by stagnant blood stream knot, helps the twelve regular channels.6. " Japan hanako materia medica ": control waist knee joint soft timid cold a little less than, broken crux, evacuation of pus pain relieving, puerperal cardiac and abdominal pain blood fortune, the tire that falls, tonifying YANG.7. amplification on Canon of Materia Medica: with Herba Cistanches infusing drugs in wine clothes, kidney tonifying; Bamboo wood thorn incarnation, mash net for catching birds or fish it, go out.The traditional Chinese medical science thinks, its property bitter but sweet flavor acid is flat, has promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, draws the descending effect of blood (fire), be usually used in treating the gynaecopathia such as amenorrhea, dysmenorrhea, menoxenia, puerperal abdonimal pain of stagnation of blood stasis, traumatic injury, the soreness of waist and knee joint of suffering from a deficiency of the kidney, weakness of the lower extremities, hematuria; dysuria, Urethra astringent pain and intimately go up the cards such as headache that inflammation causes, dizzy, haematemesis, epistaxis.1. the inclined to one side nourishing the liver and kidney of Radix Achyranthis Bidentatae merit, strengthens waist knee joint: the soreness of bones and muscles causing for deficiency of the liver and kindey, lumbocrural pain.2, Radix Cyathulae is with promoting blood circulation to restore menstrual flow, and wind-damp dispelling is good at: for blood stasis amenorrhea and rheumatalgia.This moral character is kind descending, and fire and the top of specially controlling inflammation are hemorrhage, therefore be usually used in the diseases such as conjunctival congestion, pharyngeal swelling, haematemesis, epistaxis of hyperactivity of deficient fire or heat in blood upper punch.

Rhizoma Sparganii, bitter in the mouth, property is flat.Removing blood stasis, circulation of qi promoting, removing food stagnancy pain relieving.Clinical practice: be applicable to kinds of tumors, as ovarian cancer, cervical cancer, hepatocarcinoma etc.The ovarian cancer that compatibility treatment QI and blood knot amasss, the blood stasis stasis of blood is stagnant, the cervical cancers etc. such as normal and Rhizoma Cyperi, Rhizoma Curcumae, Radix Arnebiae (Radix Lithospermi), Fructus Fici Pumilae.The hepatocarcinoma that compatibility treatment qi depression to blood stasis, the pyretic toxicity such as conventional Herba Hedyotidis Diffusae, Pericarpium Arecae, Poria, Rhizoma Curcumae pent up.In addition these product are also applicable to stagnation of QI and blood, abdominal part caking, hepatosplenomegaly, amenorrhea stomachache, food stagnation distending pain etc.

Rhizoma Curcumae, 1) removing blood stasis promoting the circulation of QI to relieve pain: this product effect is similar to Rhizoma Sparganii, but warm concerted effort is larger, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.2) long-pending eliminating stagnation: the pain relieving of this product energy circulation of qi promoting removing food stagnancy, for eating accumulation, breast abdominal distention is vexed has a pain.3) removing blood stasis, women's amenorrhea, or the phlegm-damp congestion lump in the abdomen addiction piece that condenses and form.4) promoting the circulation of QI to relieve pain: be suitable for drinking and eating irregularly, the card of gastral cavity abdomen overflow pain.Suitable compatibility, deficient syndrome, the case of a physically strong patient running a high fever all can.Many raw using.5) points for attention: contraindication in pregnancy

Radix Aconiti Lateralis Preparata, recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, dispersing cold for relieving pain." for recuperating depleted YANG and rescuing the patient from collapse the first product medicine " for excess of YIN gram sun, and loss of YANG due to profuse perspiration vomits and diarrhoea that it is contrary to faint, cold extremities faint pulse, trusted subordinate's cold type of pain, cold-dysentery, beriberi edema, anemofrigid-damp arthralgia, sexual impotence, cold womb, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, the disease of carbuncle of yin nature skin infection and all chronic diseaseses.And Radix Aconiti Lateralis Preparata is to hypophysis---interrenal system has excitation, can also excited vagus and tool cardiotonic.Radix Aconiti Lateralis Preparata should not eat together with Semen Glycines preparatum, is mainly because Semen Sojae Preparatum abnormal smells from the patient bitter cold or salty-cold.Radix Aconiti Lateralis Preparata is the medicine of the large heat of great Xin, is warming the interior recuperating depleted YANG medicine, both medicated opposites, and edible meeting simultaneously reduces drug effect.

Rhizoma Curculiginis, kidney-replenishing, bone and muscle strengthening, cold expelling is wet.Control sexual impotence cold sperm, urinary incontinence, metrorrhagia, trusted subordinate's cold type of pain, cold arthralgia of loins and legs, carbuncle, scrofula, yang deficiency cold diarrhea.The diseases such as sexual impotence essence is cold, and waist knee joint is air-cooled, muscles and bones flaccidity syndrome and arthralgia syndrome.In ancient prescription, there is Rhizoma Curculiginis ball, energy strengthening bone and muscle, benefit spirit, improving eyesight, black beard and hair.1. " Haiyao Bencao, Oversea Materia Medica ": main air, mend warm waist foot, clear settling five organs, bone and muscle strengthening, helps digestion.Declare and multiple benefit, main husband's seven kinds of impairments, improve visual and auditory acuity, beneficial biceps, fills out bone marrow, Yiyang.2. " Japan hanako materia medica ": control all pathogenic wind, mend five kinds of strain and seven kinds of impairment, the appetizing therapeutic method to keep the adverse QI flowing downwards.3. " Kaibao Bencao ": main trusted subordinate's cold air can not be eaten, the air-cooled arthritis with muscular contracture of waist foot can not be gone, husband's asthenia, old man loses excessive.4. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": control the red hematochezia that collapses of married woman, attack carbuncle, evacuation of pus.5. " the SHENGCAO property of medicine is standby to be wanted ": the kidney invigorating, pain relieving, controls nebulousurine, reason phlegm-fire, pot is carnivorous.Ten steam nine shines, and with granulated sugar, hides, and morning, tea sent, and can strengthen spirit, black beard and hair.6. " beautiful Chinese catalpa medicine solution ": control skin wind leprosy.

Radix Morindae Officinalis, impotence due to deficiency of the kidney; Seminal emission premature ejaculation; Few abdomen cold type of pain; Incontinence of urine; Cold womb is infertile; Anemofrigid-damp arthralgia; Soreness of the waist and knees; Rheumatism limb gas.Praise and educate red Jing-Yue Complete Works: kidney invigorating and YANG supporting.The unicorn ball " through proved recipe " of giving birth: male infertility, infertilitas feminis.Herba Cistanches tonify deficiency QI invigorating side " preemergency prescriptions worth thousand gold ": the five internal organs asthenia; JINGANG WAN " Zhang Shi doctor is logical ": the flaccidity involving in the bone of suffering from a deficiency of the kidney.

Semen Gymnocladi Chinensis, sweet; Temperature.Return lung; The heart; Large intestine channel.Function cures mainly: eliminate the phlegm; Relieving constipation; Diuresis; Parasite killing.Main pertinacious phlegm blocks; Large intestine constipation due to pathogenic wind; Dysentery; Stranguria; Scabies.

Radix Salviae Miltiorrhizae, there is promoting blood circulation to remove blood stasis, detumescence hemostasis, anti-inflammatory analgetic, menstruction regulating and pain relieving, coronary artery dilator, improve myocardial ischemia situation, with all worries set aside, blood sugar lowering and the effect such as antibiotic reduce blood pressure, calm the nerves, to menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the diseases such as angina pectoris have certain curative effect.In addition, modern medicine experiment showed, that Radix Salviae Miltiorrhizae also has the function of anti-platelet aggregation, reduction blood viscosity and the inside and outside blood coagulation system of adjusting, is that a kind of safety is treated again the natural Chinese medicine of cardiovascular disease reliably.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect, often apply with Rhizoma Chuanxiong compatibility.In treatment breast abdomen pain, belong to aspect qi depression to blood stasis, often coordinate the medicines such as Fructus Amomi, Lignum Santali Albi with using.For epidemic febrile disease heat, enter that macule is sent out in nutrient blood, body, coma is irritated.The medicines such as normal and Radix Rehmanniae, Cornu Bubali, Radix Scrophulariae are with use.For severe palpitation, insomnia.The medicines such as normal and Semen Ziziphi Spinosae, Semen Platycladi coordinate use together.

Flos Carthami, warm in nature, acrid in the mouth, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury.When ancients often have what blood in vivo, often add Flos Carthami tate.Bundle is boiled available one day twice foot bath, applicable various varicosis, and peripheral neuritis, blood circulation is bad, lower limb numbness or the congestion such as livid purple.Irregular menstruation, puerperal abdonimal pain, lump in the abdomen, the disease such as traumatic stasis swells and ache, ulcer sore pain.Come from " Bencao Tujing ": " red blue flower, Flos Carthami also.The present has it everywhere.Other ground threshing is planted, and winter and cloth is in Radix Rehmanniae Preparata, to raw Seedling of spring, and Xia Naiyou flower, the lower Qiu that does converges, thorniness, it is upper that pistil goes out Qiu, and people from garden holds to reveal and adopts it, adopts and appears again, to stopping to the greatest extent.Solid in Qiu, white, as large in Semen Phaseoli.It spends suddenly and violently dry very red to dye, and makes swallow fat.After main product, disorders of blood is victory.In fact also same.Leaf is quite like blue, therefore there is blue name." " book on Chinese herbal medicine is stated hook unit ": " removing blood stasis wine boils for red blue flower, the decocting that nourishes blood.”

Radix Et Rhizoma Rhei, attacks stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances.Cure mainly: excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Scald.

Radix Notoginseng, the efficacy effect of Radix Notoginseng is very large, and it is warm in nature, and acrid in the mouth has scattered silt hemostasis, and the effect of subduing swelling and relieving pain can be used for treating epistaxis, has blood in stool, the disease such as metrorrhagia, spitting of blood, haematemesis, traumatic hemorrhage, breast ventral spine pain.And the flavone compound in Radix Notoginseng has effect, sitosterol and the blood fat reducing of daucosterol energy that improves blood supply of cardiac muscle, increases blood vessel elasticity, coronary artery dilator.Normal food Radix Notoginseng, has preventive and therapeutic action to coronary heart diseases and angina pectoris.Return Liver Channel; Stomach warp; Heart channel; Lung meridian; Large intestine channel.Function: hemostasis; Loose blood; Analgesic therapy.Taboo: deficiency of qi and blood dysmenorrhea, menoxenia should not select, its show as menstrual period or through after lower abdomen dull pain pain relieved by pressing.Cure mainly: fall and flutter congestive edema, thoracic obstruction angor, lump in the abdomen; Blood stasis amenorrhea; Dysmenorrhea; The cloudy stomachache of the stasis of blood in puerperal; Sore, carbuncle and painful swelling.

Lignum Sappan, blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.As married woman's amenorrhea due to stagnation of blood, dysmenorrhea, postpartum stagnation cardiac and abdominal pain, puerperal blood faints, carbuncle, traumatic injury, tetanus.Heartwood is used as medicine, and is hematocathartic, have eliminate the phlegm, pain relieving, invigorate blood circulation, the effect of loose wind.Yunnan plant institute extracts a kind of haematoxylin from the heartwood of Lignum Sappan in recent years, can be used for the dyeing of organic section making, and effect is not second to the brazilin of import.This kind of sapwood is yellow micro-red, the reddish brown brown of heartwood, and texture is oblique, and structure is thin, and material is hard heavy, glossy, and dry rear few cracking, is carpentry timber.1. Tang Materia Medica: main removing blood stasis, puerperal, blood feeling of distension and oppression was wanted the dead.2. supplement to the Herbal: main cholera vomiting and people often vomit, with being decocted in water for oral dose it.Removing blood stasis is when boiling as good with wine.3. " Haiyao Bencao, Oversea Materia Medica ": main asthenia blood addiction gas is stopped up stagnant; Lochia is uneasy, stirs pain in abdomen; And blockage of main and collateral channels, men and women's apoplexy, trismus and inability to speak.Should carefully grind the fragrant smalls tool for weighing medicine in ancient China of the nipple ，Jiu Jian Soviet side and go dregs to be taken after mixing with liquid, the vertical evil thing of telling is recovered.4. " Japan hanako materia medica ": control married woman's vim and vigour cardiac and abdominal pain, month uncomfortable and postpartum debility of time.Evacuation of pus pain relieving, subduing inflammation is flutterred damage blood stasis, woman's aphonia, blood is kept silent, dysentery with red and white feces rear minute shoot.5. " medicine origin ": " curing mainly secret formula " cloud, disperse the exterior and the interior pathogenic wind.Broken dead blood.6. Lee fruit: the broken dead blood of skin infection, puerperal deteriorated blood.7. " medical center bun is wanted ": reinforcing the heart dissipating blood stasis, except the wind heat of the absurd work of blood system.

Herba Pyrolae, energy tonify deficiency, kidney tonifying, expelling wind and removing dampness, promoting blood flow to regulate menstruation, the kidney invigorating bone strengthening, cough-relieving, hemostasis.Cure mainly: main lumbago due to renal deficiency, rheumatic arthralgia, soft, the new chronic cough of muscles and bones flaccidity are coughed, haematemesis, epistaxis, metrorrhagia, traumatic hemorrhage.1, " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " warm in nature flat, acrid in the mouth.Control bones and muscles pain, the disease of expectorant inflammation." 2, " Zhiwu Mingshi Tukao ": " the raw greenery of Herba Pyrolae floor file, the purple back of the body, face has white thread, slightly like Herba Houttuyniae and micro-length, root is also purple." 3, " middle traditional Chinese medicines are planted will ": control chronic consumptive disease, cough-relieving.4, " Chongqing medical herbs ": control weak consumptive disease, cough, leucorrhea.5, " Chinese herbal medicine is commonly used in Sichuan ": expelling wind and removing dampness, spasmolytic is throbbed with fear, night sweat.6, " Shaanxi Chinese herbal medicine ": kidney invigorating and YANG supporting, regulating menstruation and activating blood, astringing to arrest bleeding.

Pubescent angelica root, anti-inflammation, expelling wind and removing dampness, promoting blood circulation and stopping pain.Control pneumonia, acute appendicitis, acute gastroenteritis, bacillary dysentery, rheumatalgia, traumatic injury, fracture.Medicinal part herb, acrid in the mouth, hardship, property is flat.There are anti-inflammation, heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation and stopping pain, the effects such as synthetism of stimulating the menstrual flow, are used for the treatment of various diseases associated with inflammation, rheumatic arthritis, lumbago and skelalgia, sore swollen toxin pneumonia, appendicitis, acute cellulitis, tumor, traumatic injury, fracture etc.In recent years being used for the treatment of cancer of pancreas, gastric cancer, rectal cancer, hepatocarcinoma, esophageal carcinoma etc. has compared with remarkable result.Caulis Trachelospermi, has expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, and clearing away heat and cooling blood, the effect of removing toxic substances and promoting subsidence of swelling, cures mainly dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence.For rheumatism pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.1. " detailed outline ": trachelospermum jasminoide, abnormal smells from the patient is gentle, and the main muscles and bones of its merit joint wind heat carbuncle bleaches resistance to old, and doctor's aquatic foods are known user, near low-priced and neglect with it.Clothes when infusing drugs in wine ear.2. " must join book on Chinese herbal medicine ": trachelospermum jasminoide, join Rhizoma Belamcandae, Fructus Gardeniae, control poison and attack larynx.Join ginseng, Siberian cocklebur, Os Draconis, control nebulousurine very.3. " key medicine is divided agent ": the merit of trachelospermum jasminoide, specially in relaxing muscles and tendons and activating QI and blood in the collateral.The contracture of all patient's muscle arteries and veins, is difficult for stretching and bends person, clothes invariably obtain effect, can not neglect also.4. " book on Chinese herbal medicine justice ": trachelospermum jasminoide abnormal smells from the patient, the bitter temperature of " herbal classic " meaning, lid is invigorated blood circulation it with function the meridian dredging, therefore think temperature.So " herbal classic " cures mainly, and pure is heat symptom-complex, non-warm known, therefore " not Lu " transforms into and be slightly cold, and " for the emperor's inspection " draws saying that Lee works as, and thinks that Great Cold also.This thing is apt to away passages through which vital energy circulates, sensible podomere, the dead flesh of " herbal classic " main air heat, " not record " supports kidney, main waist hip bitterly, hard muscle, sharp joint, is all this justice.It controls carbuncle, mouthpiece is swollen, xerostomia scorching tongue, and all the function of purging with bitter and cold drugs is also." not Lu " calls it except that gas, with pathogenic heat.All " herbal classic ", " not Lu " pathogen two words, include in the extensivelyst, each is main to some extent in fact, is not general diction, reader when with anticipate contrary it, self energy is realized, and can not mix up a routine person.Only frightenedly enter abdomen four words, very can not separate, when paying wealthy doubting.Respectful meaning treatment blood agglomeration in puerperal is good greatly, and lid reveals obstructed with the stasis of blood, and hardship is let out removing blood stasis with potent drugs, and kind dredging collateral, is with master's.Call again the main Agkistrodon halys sore heart vexed, heat clearing away drop-down, Gu the good medicine of removing toxic substances.Call again injury by sword or axe skin ulcer, apply vertical being recovered, the god that external treatment is invigorated blood circulation is again red.Hide the main wind cutting of device meaning, " herbal classic " controls the dead flesh of wind heat, the justice in " not Lu " sharp joint.Modern active in order to Shu Jie, a surname's blood stasis dispelling pain is very tested.

Caulis Piperis Kadsurae, wind-damp dispelling, the meridian dredging, stopping numbness pain.For anemofrigid-damp arthralgia, arthrodynia of extremities, the contracture of muscle arteries and veins, joint stuffiness.1. " book on Chinese herbal medicine is new again ": the network of passing through, and blood vessels, alleviating distention in middle-JIAO is regulated the flow of vital energy, lower wet except wind, and reason waist beriberi, controls hernia, antiabortive.2. " Zhejiang Chinese medicine handbook ": a surname's numbness, removing dampness, Tongluo Shujin.Control lower limb knee joint flaccidity syndrome and arthralgia syndrome, arthralgia.3. " Chinese medicinal herbal ": " pungent, tepor." " book on Chinese herbal medicine is new again ": " enters the heart, kidney two warps." 4. " not Lu ": main incised wound pain.5. " Kaibao Bencao ": main air blood, mend aging, play sun, strong waist foot, eliminating impediment, bleaches, and by cold air, air draft is evil.Also liquor takes, and also infusing drugs in wine takes, and use it the eleventh month of the lunar calendar.6. " Bencao Tujing ": control lumbago.7. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": control the muscle and tendon injury of cold-damp numbness, dispel the wind, bones and muscles pain, diuresis and pains in the penis, pyretic stranguria from the beginning of, diuresis is rapidly.8. " detailed outline ": liquor clothes, control gas cough.

Embodiment 1 patch

The embodiment of the present invention provides a kind of Chinese medicine composition that is used for the treatment of knee osteoarthritis, and dosage form is patch, and its preparation method is as follows:

A. take Radix Angelicae Sinensis 1600g, Herba Taxilli 1800g, Rhizoma Chuanxiong 1700g, Rhizoma Et Radix Notopterygii 1500g, Radix Angelicae Pubescentis 2900g, Radix Gentianae Macrophyllae 1500g, Ramulus Cinnamomi 1500g, Olibanum 1500g, Radix Aucklandiae 1500g, Ramulus Mori 1700g, Herba Agrimoniae 1500g, Cortex Eucommiae 1500g, Radix Rehmanniae Preparata 1400g, Rhizoma Corydalis 1400g, hide Flos Caryophylli 1500g, Caulis Spatholobi 1600g, Radix Achyranthis Bidentatae 2100g, Rhizoma Sparganii 1600g, Rhizoma Curcumae 1600g, Radix Aconiti Lateralis Preparata 1500g, Rhizoma Curculiginis 1800g, Radix Morindae Officinalis 1700g, Semen Gymnocladi Chinensis 1200g, Radix Salviae Miltiorrhizae 1500g, Flos Carthami 1700g, Radix Et Rhizoma Rhei 1500g, Radix Notoginseng 1500g, Lignum Sappan 1500g, Herba Pyrolae 1600g, pubescent angelica root 1400g, Caulis Trachelospermi 1400g, Caulis Piperis Kadsurae 1500g, add in the ethanol of 10 times of amounts 85%, heating and refluxing extraction 2 times, each 2 hours, extracting solution is standing, obtain extracting solution 1, medicinal residues are standby,

B. the medicinal residues that in step a, ethanol extraction is crossed are added to water heating and refluxing extraction twice, each 2 hours, merge extractive liquid, was standing, obtained extracting solution 2;

C. extracting solution 1 and extracting solution 2 merged, in suction concentrating under reduced pressure tank, be decompressed to 0.06MPa, temperature remains on 70 ℃, and being concentrated into relative density is 1.20, the extractum of temperature to 65 ℃, and heating is concentrated into pasty state, with wine, vinegar, Mel, is in harmonious proportion and obtains patch.

Embodiment 2 capsules

The embodiment of the present invention provides a kind of Chinese medicine composition that is used for the treatment of knee osteoarthritis, dosage form is capsule, its preparation method comprises the following steps: take Radix Angelicae Sinensis 1200g, Herba Taxilli 2000g, Rhizoma Chuanxiong 1200g, Rhizoma Et Radix Notopterygii 1200g, Radix Angelicae Pubescentis 4200g, Radix Gentianae Macrophyllae 1700g, Ramulus Cinnamomi 1200g, Olibanum 1700g, Radix Aucklandiae 1900g, Ramulus Mori 1400g, Herba Agrimoniae 1100g, Cortex Eucommiae 1000g, Radix Rehmanniae Preparata 1000g, Rhizoma Corydalis 1800g, hide Flos Caryophylli 1200g, Caulis Spatholobi 1200g, Radix Achyranthis Bidentatae 1500g, Rhizoma Sparganii 1200g, Rhizoma Curcumae 1200g, Radix Aconiti Lateralis Preparata 1000g, Rhizoma Curculiginis 1200g, Radix Morindae Officinalis 1200g, Semen Gymnocladi Chinensis 1500g, Radix Salviae Miltiorrhizae 1000g, Flos Carthami 1200g, Radix Et Rhizoma Rhei 1000g, Radix Notoginseng 1000g, Lignum Sappan 1100g, Herba Pyrolae 1200g, pubescent angelica root 1800g, Caulis Trachelospermi 1700g, Caulis Piperis Kadsurae 1200g, be ground into after coarse powder, further pulverize again, cross 100 order～120 mesh sieves, the fine powder amount that enable pass is sieved is reaching 30%, collection obtains fine powder a by the fine powder of sieve, can not by the coarse powder of 120 mesh sieves, drop into multi-function extractor again extracts twice, adding for the first time 8 times of water gagings decocts 2 hours, adding for the second time 7 times of water gagings decocts 2 hours, merge decocting liquid twice, filter to get filtrate, heating is concentrated into pasty state, put into after 80 ℃ of oven dry of baking oven cooling, grind to form fine powder b, after fine powder a is mixed with fine powder b, incapsulate in housing, obtain capsule.

Embodiment 3 tablets

The embodiment of the present invention provides a kind of Chinese medicine composition that is used for the treatment of knee osteoarthritis, and dosage form is tablet, and its preparation method comprises the following steps:

A, take Radix Angelicae Sinensis 2000g, Herba Taxilli 1200g and Rhizoma Chuanxiong 2200g, put into the ethanol of 10 times of amounts 75%, heating and refluxing extraction 2 times, each 1.5 hours, extract active ingredient, 2 extracting solution are merged standing, obtain extracting solution 1;

B, take Rhizoma Et Radix Notopterygii 1900g, Radix Angelicae Pubescentis 1000g, Radix Gentianae Macrophyllae 1100g, Ramulus Cinnamomi 1900g, Olibanum 1200g, Radix Aucklandiae 1000g, Ramulus Mori 2400g, Herba Agrimoniae 2000g, Cortex Eucommiae 1500g, Radix Rehmanniae Preparata 1200g, Rhizoma Corydalis 1200g, hide Flos Caryophylli 1700g, Caulis Spatholobi 1700g, Radix Achyranthis Bidentatae 1900g, Rhizoma Sparganii 1800g, Rhizoma Curcumae 1800g, Radix Aconiti Lateralis Preparata 1800g, Rhizoma Curculiginis 2200g, Radix Morindae Officinalis 2200g, Semen Gymnocladi Chinensis 1700g, Radix Salviae Miltiorrhizae 1700g, Flos Carthami 1700g, Radix Et Rhizoma Rhei 1300g, Radix Notoginseng 1900g, Lignum Sappan 1300g, Herba Pyrolae 1600g, pubescent angelica root 1200g, Caulis Trachelospermi 1100g, Caulis Piperis Kadsurae 1800g, put into 10 times of water gagings, heating and refluxing extraction 3 times, each 40 minutes, 3 extracting solution are merged standing, obtain extracting solution 2,

C, extracting solution 1 and extracting solution 2 merged, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is that temperature is while being 20 ℃ 1.08; The macroporous adsorptive resins eluting twice that is 10L through volume by filtrate, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain crude drug, add starch or dextrin tabletting, obtain tablet.Every 0.3g.

Pharmacology pharmacodynamic experiment:

1, external acute dermal toxicity test

Test method: according to Ministry of Public Health " cosmetics health standard " (2002) second portion " acute dermal toxicity test " test method(s) of once limiting the quantity of, 20 of SD rats, male and female half and half, body weight 90g～180g, the patch that the embodiment of the present invention 1 is obtained, one time percutaneous is smeared 5000mg/kg body weight dosage, observe 15 days, do not find obvious poisoning symptom, nothing death, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.

2, external acute skin irritation test

Test method: these product are according to 6.3 joints in Ministry of Public Health " cosmetics health standard " (2002) second portions " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg～3kg, the patch 0.5g that gets the present embodiment 1 directly spreads upon on the skin of animal left side (opposite side in contrast), adopt blocking test, 4 hours application time, after off-test, use the residual tested material of warm water washing, 1h after removing tested material, 24h, 48h and 72h observe respectively the dermoreaction of the tested district of animal and check plot, top average is " 0 ", judge that these product are to animal skin nonirritant.

3, acute toxicity testing for oral administration

40 of application NIH mices, SPF level, male and female half and half, body weight 16～20g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, matched group and administration group, test front fasting 12 hours; Tablet dissolved prepared by embodiments of the invention 3 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and records toxic reaction and the death toll of mice.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tablet LD50 of the present invention > 32.9 crude drugs/kg, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.4g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 20g) oral administration gavage Chinese medicine of the present invention is quantity 901 times.Therefore Chinese drug anesthesia medicine acute toxicity of the present invention is low, clinical drug safety.

4. take long term toxicity test orally:

By the capsule of the embodiment of the present invention 2 to mice by 7.81,18.34 and 12 weeks (1.0ml/100g body weight of 40.11g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 12 weeks and drug withdrawal are after 4 weeks, and each internal organs of rat are all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to rat long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Clinical data

1, data and method

1.1 physical data: during selecting in JIUYUE, 2011-2012 year August, the patient of the knee osteoarthritis of diagnosis and treatment is totally 360 examples, male 178 examples wherein, female's 182 examples, 40-50 year patient 34 examples, 51-60 year is totally 92 examples, and 61-70 year is totally 108 examples, 70 years old above 126 example.Be divided at random three groups, treatment group 1-3, every group of 120 examples.Three groups of patients comparing difference not statistically significant aspect age, sex, state of an illness weight, and according to the weight out-patient treatment of the state of an illness.

1.2 diagnostic criterias:

The knee joint standard that adopts Americanism damp disease institute (ACR) to formulate: having gonalgia and this knee joint X to be shown with mutually bone good horse, is with following arbitrary person:

A, Nian Ling≤40 year old;

B, the knee joint of getting involved be stiff < 30min;

C, there is bony crepitus.

1.3 efficacy assessment standards:

Clinical cure: the gonalgia disappears, joint motion freely, recovers orthobiosis and ability to work;

Effective: the gonalgia obviously alleviates, joint motion is slightly limited, can maintain orthobiosis and work;

Effective: the gonalgia alleviates, joint motion makes moderate progress, and squats down, stands up, above can adhere to certain hour downstairs;

Invalid: the fruit of failing to respond to any medical treatment.

1.4 treatment group 1-3, are used respectively the Chinese medicine composition of the different preparations of embodiment of the present invention 1-3 to treat:

(1) treatment group 1:120 example patient suffers from knee osteoarthritis after diagnosing, use the patch of the embodiment of the present invention 1 to treat, patch is spread on to affected part, paste medicine part, need clean in advance, with the fixing patch of preservative film or medical adhesive tape, after 5h, take off, every day 1-2 time, 7 days is a course for the treatment of, uses continuously 5-10 the course for the treatment of.Drug withdrawal further consultation after 1 week, 69 routine patient treatment effects are clinical cure, and 28 routine patient treatment effects are effective, and 15 routine patient treatment effects are effective, and 8 routine patient treatments are invalid.During treatment, do not find other side effect that medicine brings, follow up a case by regular visits to half a year, clinical cure patient is all without any the symptom recurring.

(2) treatment group 2:120 example patient suffers from knee osteoarthritis after diagnosing, uses the embodiment of the present invention 2 capsules to treat, and every day 3 times, a 0.4g, 7 days is a course for the treatment of, uses continuously 5-10 the course for the treatment of.Drug withdrawal further consultation after 1 week, 67 routine patient treatment effects are clinical cure, and 25 routine patient treatment effects are effective, and 19 routine patient treatment effects are effective, and 9 routine patient treatments are invalid.During treatment, do not find other side effect that medicine brings, follow up a case by regular visits to half a year, clinical cure patient is all without any the symptom recurring.

(3) treatment group 3:120 example patient suffers from knee osteoarthritis after diagnosing, uses the embodiment of the present invention 3 tablets to treat, and every day 3 times, a 2-3 sheet, 7 days is a course for the treatment of, uses continuously 5-10 the course for the treatment of.Drug withdrawal further consultation after 1 week, 65 routine patient treatment effects are clinical cure, and 27 routine patient treatment effects are effective, and 17 routine patient treatment effects are effective, and 11 routine patient treatments are invalid.During treatment, do not find other side effect that medicine brings, follow up a case by regular visits to half a year, clinical cure patient is all without any the symptom recurring.

2, concrete case

Case 1: grandson, man, 73 years old, gonalgia and this knee joint X were shown with bone good horse mutually for many years.Through particular exam, be diagnosed as knee osteoarthritis, use the patch of embodiment 1 to treat, during use, patch is spread on to affected part, paste medicine part, need clean in advance, with the fixing patch of preservative film or medical adhesive tape.After 5h, taking off, every day 2 times, 7 days is a course for the treatment of, uses continuously 8 courses for the treatment of.Drug withdrawal further consultation after 1 week, the gonalgia disappears, and joint motion freely, recovers orthobiosis and ability to work, does not find other side effect that medicine brings during treatment, follows up a case by regular visits to half a year, and patient is without any the symptom of recurrence.

Case 2: Zhang, female, 65 years old, gonalgia and this knee joint X were shown with bone good horse mutually for many years, and the knee joint of getting involved is stiff < 30min; There is bony crepitus, through particular exam, be diagnosed as knee osteoarthritis.Use the capsule of embodiment 2 to treat, every day 3 times, a 0.4g, 7 days is a course for the treatment of, uses continuously 8 courses for the treatment of.Drug withdrawal further consultation after 1 week, the gonalgia obviously alleviates, and joint motion is slightly limited, can maintain orthobiosis and work, does not find other side effect that medicine brings during treatment, follows up a case by regular visits to half a year, and patient is without any the symptom of recurrence.

Case 3: Lee, man, 60 years old, gonalgia and this knee joint X were shown with bone good horse mutually for many years, and the knee joint of getting involved is stiff < 30min; There is bony crepitus, through particular exam, be diagnosed as knee osteoarthritis.Use the tablet of embodiment 3, every day 3 times, one time 2, within 7 days, be a course for the treatment of, use continuously 8 courses for the treatment of.Drug withdrawal further consultation after 1 week, the gonalgia obviously alleviates, and joint motion is slightly limited, can maintain orthobiosis and work, does not find other side effect that medicine brings during treatment, follows up a case by regular visits to half a year, and patient is without any the symptom of recurrence.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims

1. a Chinese medicine composition that is used for the treatment of knee osteoarthritis, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of various raw medicinal materials is: 10～20 parts of Radix Angelicae Sinensis, 10～25 parts of Herba Taxillis, 10～25 parts of Rhizoma Chuanxiongs, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～50 parts of Radix Angelicae Pubescentiss, 10～20 parts of Radix Gentianae Macrophyllae, 10～20 parts of Ramulus Cinnamomi, 10～20 parts of Olibanums, 10～20 parts of the Radix Aucklandiae, 10～25 parts of Ramulus Moris, 10～20 parts of Herba Agrimoniaes, 10～20 parts of the Cortexs Eucommiae, 10～20 parts of Radix Rehmanniae Preparata, 10～20 parts of Rhizoma Corydalis, hide Flos Caryophylli 10-20 part, 10～20 parts of Caulis Spatholobis, 10～25 parts of Radix Achyranthis Bidentataes, 10～20 parts of Rhizoma Sparganii, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Aconiti Lateralis Preparatas, 10～25 parts of Rhizoma Curculiginises, 10～25 parts of Radix Morindae Officinaliss, Semen Gymnocladi Chinensis 10-20 part, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～25 parts, Flos Carthami, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Notoginseng, 10～20 parts of Lignum Sappans, 10～20 parts of Herba Pyrolaes, 10～20 parts of pubescent angelica roots, 10～20 parts of 10～20 parts of Caulis Trachelospermis and Caulis Piperis Kadsuraes.

2. the Chinese medicine composition that is used for the treatment of knee osteoarthritis according to claim 1, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: 12～18 parts of Radix Angelicae Sinensis, 15～22 parts of Herba Taxillis, 12～23 parts of Rhizoma Chuanxiongs, 12～17 parts of Rhizoma Et Radix Notopterygiis, 17～42 parts of Radix Angelicae Pubescentiss, 12～18 parts of Radix Gentianae Macrophyllae, 12～18 parts of Ramulus Cinnamomi, 12～17 parts of Olibanums, 11～19 parts of the Radix Aucklandiae, 14～21 parts of Ramulus Moris, 11～18 parts of Herba Agrimoniaes, 10～20 parts of the Cortexs Eucommiae, 10～20 parts of Radix Rehmanniae Preparata, 10～18 parts of Rhizoma Corydalis, hide Flos Caryophylli 13-17 part, 12～20 parts of Caulis Spatholobis, 15～25 parts of Radix Achyranthis Bidentataes, 12～20 parts of Rhizoma Sparganii, 12～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Aconiti Lateralis Preparatas, 10～25 parts of Rhizoma Curculiginises, 10～25 parts of Radix Morindae Officinaliss, Semen Gymnocladi Chinensis 12-17 part, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～25 parts, Flos Carthami, 10～20 parts of Radix Et Rhizoma Rhei, 10～20 parts of Radix Notoginseng, 10～20 parts of Lignum Sappans, 10～20 parts of Herba Pyrolaes, 10～18 parts of pubescent angelica roots, 12～18 parts of 13～17 parts of Caulis Trachelospermis and Caulis Piperis Kadsuraes.

3. the Chinese medicine composition that is used for the treatment of knee osteoarthritis according to claim 1 and 2, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: 16 parts of Radix Angelicae Sinensis, 18 parts of Herba Taxillis, 17 parts of Rhizoma Chuanxiongs, 15 parts of Rhizoma Et Radix Notopterygiis, 29 parts of Radix Angelicae Pubescentiss, 15 parts of Radix Gentianae Macrophyllae, 15 parts of Ramulus Cinnamomi, 15 parts of Olibanums, 15 parts of the Radix Aucklandiae, 17 parts of Ramulus Moris, 15 parts of Herba Agrimoniaes, 15 parts of the Cortexs Eucommiae, 14 parts of Radix Rehmanniae Preparata, 14 parts of Rhizoma Corydalis, hide 15 parts of Flos Caryophyllis, 16 parts of Caulis Spatholobis, 21 parts of Radix Achyranthis Bidentataes, 16 parts of Rhizoma Sparganii, 16 parts of Rhizoma Curcumae, 15 parts of Radix Aconiti Lateralis Preparatas, 18 parts of Rhizoma Curculiginises, 17 parts of Radix Morindae Officinaliss, 15 parts of Semen Gymnocladi Chinensiss, 15 parts of Radix Salviae Miltiorrhizaes, 17 parts, Flos Carthami, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Radix Notoginseng, 15 parts of Lignum Sappans, 16 parts of Herba Pyrolaes, 14 parts of pubescent angelica roots, 15 parts of 14 parts of Caulis Trachelospermis and Caulis Piperis Kadsuraes.

4. a preparation method for the Chinese medicine composition that is used for the treatment of knee osteoarthritis as described in claim 1-3 any one, is characterized in that, the dosage form of described Chinese medicine composition is patch, and described preparation method comprises the following steps:

B. the medicinal residues of more above-mentioned ethanol extraction being crossed, add water heating and refluxing extraction 1 time, obtain extracting solution 2;

5. the preparation method that is used for the treatment of the Chinese medicine composition of knee osteoarthritis according to claim 4, it is characterized in that, in described step a, the raw medicinal material taking by described ratio of weight and number adds in the ethanol of 10 times of amount 60-85%, heating and refluxing extraction 2 times, each 1～2 hour, extracting solution is standing, obtain extracting solution 1, medicinal residues are standby.

6. the preparation method that is used for the treatment of the Chinese medicine composition of knee osteoarthritis according to claim 4, is characterized in that, in described step b, the medicinal residues that in step a, ethanol extraction is crossed are added to twice of water heating and refluxing extraction, each 1～2 hour, merge extractive liquid, was standing, obtained extracting solution 2.

7. the preparation method that is used for the treatment of the Chinese medicine composition of knee osteoarthritis according to claim 4, it is characterized in that, in described step c, extracting solution 1 and extracting solution 2 are merged, in suction concentrating under reduced pressure tank, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, when being concentrated into temperature and being 60 ℃-70 ℃, relative density is 1.20, and heating is concentrated into pasty state, with wine, vinegar, Mel, is in harmonious proportion and obtains patch.

8. the preparation method of the Chinese medicine composition that is used for the treatment of knee osteoarthritis as described in claim 1-3 any one, it is characterized in that, the dosage form of described Chinese medicine composition is capsule, described preparation method comprises the following steps: according to ratio of weight and number, take all raw medicinal materials, be ground into coarse powder, more further pulverize, cross 100 order～120 mesh sieves, the fine powder amount that enable pass is sieved reaches 30%, and the fine powder of collecting by sieve obtains fine powder a; Can not by the coarse powder of 100 order～120 mesh sieves, drop into multi-function extractor again extracts twice, add for the first time 5-10 times of water gaging and decoct 1-2 hour, add for the second time 4-8 times of water gaging and decoct 1-2 hour, merge decocting liquid twice, filter to get filtrate, heating is concentrated into pasty state, put into after 80 ℃ of oven dry of baking oven cooling, grind to form fine powder b, after fine powder a is mixed with fine powder b, incapsulate in housing, obtain capsule.

9. a preparation method for the Chinese medicine composition that is used for the treatment of knee osteoarthritis as described in claim 1-3 any one, is characterized in that, the dosage form of described Chinese medicine composition is tablet, and described preparation method comprises the following steps:

B, according to ratio of weight and number, take surplus stock medical material, put into 10 times of water gagings, heating and refluxing extraction 3 times, each 30 minutes～1 hour, 3 extracting solution are merged standing, obtain extracting solution 2;

C, extracting solution 1 and extracting solution 2 merged, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the filtrate that while obtaining 20 ℃, relative density is 1.08; The macroporous adsorptive resins eluting twice that is 10L through volume by filtrate, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain crude drug, add starch or dextrin tabletting, obtain tablet.

10. according to the Chinese medicine composition that is used for the treatment of knee osteoarthritis described in claim 1-3 any one, it is characterized in that, the dosage form of described Chinese medicine composition is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder, enema or patch.