CN104922612A - Traditional Chinese medicine used for treating gonitis - Google Patents

Abstract

The invention relates to the field of drug formulation, in particular to traditional Chinese medicine used for treating gonitis. The traditional Chinese medicine is characterized by being made of, by weight, 5-9 parts of aconitum pendulum, 4-7 parts of passiflora wilsonii, 4-8 parts of herba siegesbeckiae, 4-7 parts of clinopodium megalanthum, 4-8 parts of cassytha filiformis, 5-8 parts of solamum melongena, 6-9 parts of curcuma zedoaria, 6-9 parts of red flowers, 7-9 parts of sambucus adnata, 6-9 parts of corydalis amabilis, 2-5 parts of ligusticum, 6-9 parts of thlaspi arvense, 2-5 parts of star-flower lysimachia, 4-6 parts of dragon blood, 2-4 parts of wood-sorrel, 4-6 parts of yam rhizome, 2-4 parts of bark of tangut barberry and 7-9 parts of cynanchum mooreanum hemsl. Drug substances are soaked through water, decocted and deslagged to obtain filter liquor.

Description

Be used for the treatment of the Chinese medicine of gonarthritis

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine being used for the treatment of gonarthritis.

Background technology

As everyone knows, knee osteoarthritis take articular cartilage degeneration as multi-faceted, the chronic inflammatory disease at many levels, in various degree of involving sclerotin, synovial membrane, joint capsule and other structures of joint of core.Its clinical manifestation mostly is that the gonalgia, swelling, dysfunction, joint are thick, Varus deformity etc.Knee osteoarthritis mostly be old people, be the disease of deficiency in origin and excess in superficiality, the long-term lacking activity due to the gonalgia in addition, cause local QI-blood circulation not enough, muscle is become homeless foster, numbness of aching, and of a specified duration easily causes myoatrophy and osteoporosis.

Current Drug therapy is mainly and controls symptom, improve the state of an illness, cartilage protection and local medicine for external use etc., based on pain relieving with improve motor function, clinically in the past based on NSAID (non-steroidal anti-inflammatory drug), glucosamine hydrochloride application is in recent years more, these medicines can amelioration of inflammation easing the pain, but the pathological change that can not change osteoarthritis is basic, namely can only treat its disease, refractory its because of; Use anesthetis partial closure, pain can disappear in a short time, but easy recurrent exerbation, prolonged application antipyretic-antalgic and hormone medicine, and to actual bodily harm is large and side effect is many, gastrointestinal side effect is obvious.

Summary of the invention

Object of the present invention is exactly to overcome above-mentioned existing technical deficiency, provides a kind of evident in efficacy, with low cost, Chinese medicine being used for the treatment of gonarthritis of having no side effect.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine being used for the treatment of gonarthritis, it is characterized in that being made up of the crude drug of following weight portion: Radix aconiti szechenyiani 5 ~ 9, Passiflora wilsonii 4 ~ 7, Herba Siegesbeckiae 4 ~ 8, Herba Clinopodii megalanthi 4 ~ 7, dodder laurel 4 ~ 8, white Radix Solani Melongenae 5 ~ 8, Rhizoma Curcumae 6 ~ 9, Flos Carthami 6 ~ 9, Herba Sambuci Adnatae 7 ~ 9, Rhizoma Corydalis Decumbentis 6 ~ 9, Rhizoma Ligustici 2 ~ 5, Herba Thlaspis 6 ~ 9, Lysimachia trientaloides Hemsl. 2 ~ 5, blood outstanding person 4 ~ 6, squeezing slurry grass 2 ~ 4, Rhizoma Dioscoreae Septemlobae 4 ~ 6, Cortex berberidis dasystachyae 2 ~ 4, Radix Tylophorae arenicolae 7 ~ 9, by above-mentioned former

Expect medicinal water soaking, filtrate of removing slag after decocting to obtain.

The invention has the beneficial effects as follows, evident in efficacy, with low cost, have no side effect.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Radix aconiti szechenyiani, Passiflora wilsonii, Herba Siegesbeckiae, Herba Clinopodii megalanthi, dodder laurel, white Radix Solani Melongenae, Rhizoma Curcumae, Flos Carthami, Herba Sambuci Adnatae, Rhizoma Corydalis Decumbentis, Rhizoma Ligustici, Herba Thlaspis, Lysimachia trientaloides Hemsl., blood outstanding person, the careless, Rhizoma Dioscoreae Septemlobae of squeezing slurry, Cortex berberidis dasystachyae, Radix Tylophorae arenicolae is adopted to be that raw material is prepared from.The every pair of its component (weight) is Radix aconiti szechenyiani 7, Passiflora wilsonii 6, Herba Siegesbeckiae 6, Herba Clinopodii megalanthi 5, dodder laurel 6, white Radix Solani Melongenae 6, Rhizoma Curcumae 7, Flos Carthami 7, Herba Sambuci Adnatae 8, Rhizoma Corydalis Decumbentis 7, Rhizoma Ligustici 4, Herba Thlaspis 8, Lysimachia trientaloides Hemsl. 3, blood outstanding person 5, squeezing slurry careless 3, Rhizoma Dioscoreae Septemlobae 5, Cortex berberidis dasystachyae 3, Radix Tylophorae arenicolae 8.Get above-mentioned 18 taste raw materials, gross weight is 176 grams, add water 800 ~ 900 milliliters and at room temperature soak 5 ~ 6 hours, slow fire decocted to 60 ~ 80 minutes, filtrate about 150 milliliters of removing slag to obtain, and medicinal residues add water 200 ~ 300ml again, decoct 20 ~ 30 minutes, to remove slag to obtain filtrate 50 ~ 70 milliliters, altogether the medicine juice of about 200 ~ 220 milliliters, i.e. obtained decoction of the present invention.Load in sterile glass vials, seal bottle cap is for subsequent use, and every day 1 dose point 2 times is oral, sooner or later respectively once, and each (medicine) being taken before meal 100 ~ 110 milliliters.

Radix aconiti szechenyiani blood circulation promoting and blood stasis dispelling of the present invention, evil-wind expelling and dampness removing, alleviating pain and detumescence.Control traumatic injury, rheumatic arthritis; Passiflora wilsonii relaxing muscles and tendons to promote blood circulation, removing dampness and killing parasites.Treating rheumatic arthritis, injury and bone fracture; Herba Siegesbeckiae can remove rheumatism, strong muscles and bones, heat-clearing and toxic substances removing; Herba Clinopodii megalanthi controls toothache, infantile malnutrition, rheumatic bone-setting, detumescence are invigorated blood circulation; Dodder laurel nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, tomorrow, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees; White Radix Solani Melongenae falls apart blood, detumescence, damp eliminating.For rheumatic arthralgia, chilblain; Rhizoma Curcumae has promoting the circulation of QI to relieve pain, long-pending eliminating stagnation, removing blood stasis effect; Flos Carthami has blood circulation promoting and blood stasis dispelling, and wet dissipation goes the effect swollen; Herba Sambuci Adnatae is dispeled the wind, diuretic, dissipating blood stasis, dredging collateral; Rhizoma Corydalis Decumbentis is invigorated blood circulation active, promoting the circulation of QI to relieve pain, and expelling wind and removing dampness has effect; Rhizoma Ligustici is used for exterior syndrome due to wind-cold, top, mountain peak pain, rheumatic arthralgia; The effects such as Herba Thlaspis has liver heat removing and eyesight improving, clearing away heat and promoting diuresis; Lysimachia trientaloides Hemsl. expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, arresting convulsion, granulation promoting; The outstanding promoting blood circulation to remove blood stasis of blood, hemostasis, pain relieving, granulation promoting; Squeeze the antipyretic diuresis of slurry grass energy, eliminating stagnated blood to disperse swelling; Rhizoma Dioscoreae Septemlobae is used for stranguria marked by chyluria, nebulousurine, leukorrhagia, rheumatic arthralgia, articular instability, lumbocrural pain; Cortex berberidis dasystachyae is used for clearing away damp-heat, relieving heat toxin; Radix Tylophorae arenicolae clearing away heat and cooling blood, function of gallbladder promoting, removing toxic substances.Main fever due to yin deficiency, asthenia chronic cough, spitting of blood, distending pain over the hypochondrium.

The each raw material of the present invention also can the embodiment that mixes of ratio (weight portion) listed by according to the form below realize.Its processing technique is identical with embodiment 1.

Embodiment	Radix aconiti szechenyiani	Passiflora wilsonii	Herba Siegesbeckiae	Herba Clinopodii megalanthi	Dodder laurel	White Radix Solani Melongenae	Rhizoma Curcumae	Flos Carthami	Herba Sambuci Adnatae	Rhizoma Corydalis Decumbentis	Rhizoma Ligustici	Herba Thlaspis	Lysimachia trientaloides Hemsl.	Blood is outstanding	Squeeze slurry grass	Rhizoma Dioscoreae Septemlobae	Cortex berberidis dasystachyae	Radix Tylophorae arenicolae
																			Two	9	7	4	7	4	8	6	9	7	9	3	9	2	6	2	6	2	7
Three	9	4	8	4	8	5	9	6	9	6	5	6	5	4	4	4	4	9
																			Four	5	6	7	6	5	7	8	8	8	9	2	9	4	5	3	5	3	8
Five	8	5	7	5	7	6	7	7	8	7	4	7	3	5	4	6	4	7

The clinical trial carried out below in conjunction with my institute is done further the present invention, is described in detail:

1, physical data

In 85 routine patients, in age 43-71 year, the course of disease is many at 3 months to 10 years, 62 years old mean age.

2, diagnostic criteria

Draft with reference to " arthritis diagnosis and treatment draft guidelines gonarthritis in 2002 diagnostic criteria of rheumatism branch of Chinese Medical Association ": 1. nearly one month frequent gonalgia repeatedly; 2. X-ray film (erect position or Weight carrying position) joint space narrows; 3. limpid, the thickness of joint fluid (at least 2 times), WBC≤200/ml; 4. person in middle and old age person (>=40 years old); 5. knee joint deadlock in morning≤30 minutes; 6. friction sound is had during activity.Meet and 1. 2. or 3. 5. 6. or 1. 4. 5. 6. namely form diagnosis.According to sign: the 1. gonalgia, walking function obstacle, exacerbation of symptoms when fatigue and stair activity, involves periarticular muscles pain.2. health check-up knee joint is unrestrained swollen, patella and inside and outside Xiyan place tenderness+, patella grinding pain, floating patella test+, it is limited that knee joint stretches flex, atrophy of quadriceps femoris.

3, Therapeutic Method

Take embodiment decoction, every day 1 dose point 2 times is oral, sooner or later each once, each (medicine) being taken before meal 100 ~ 110 milliliters 10 days was 1 course for the treatment of.

4, therapeutic outcome:

4.1 treatment evaluation criterias, judge according to " the Chinese medical disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine formulates:

Clinical cure: knee joint swelling, pain disappear, flexion-extension motion scope recovers normal, and walking is freely;

Effective: knee joint swelling substantially disappears or obviously goes down, and pain obviously alleviates, flexion-extension motion scope is normal;

Take a turn for the better: knee joint swelling and pain all have and alleviates in various degree and alleviate, and flexion-extension motion scope is also improved;

Invalid: knee joint swelling and pain are all without alleviation.

4.2 results: in 85 routine patients, clinical cure 48 example (56.5%), effective 16 examples (18.8%), 17 examples that take a turn for the better (20%), invalid 4 examples (4.7%), total effective rate is 95.3%.

Model case

1, often certain, man, 59 years old, nearly 1 year of two gonalgia, nearly 1 month over, right swelling and pain in knee obviously increases the weight of, and upper all needs staircase downstairs, seat dysstasia, and it is obvious to meet overcast and rainy symptom, morning deadlock, idol has interlocking phenomenon.Check: inner side tenderness under kneecap: left knee joint (+), right knee joint (++); Right knee joint is micro-swollen, right Range of motion of knee joint: 45 °; Tongue is greasy in vain, stringy and rolling pulse.Diagnosis: knee osteoarthritis.Take medicine of the present invention, treat 3 courses for the treatment of, two swelling and pain in knee obviously alleviate, and all the other symptoms also in alleviation trend, continue to take 3 courses for the treatment of, and recovery from illness is followed up a case by regular visits to after half a year without recurrence.

2, Hu, female, 65 years old, existing 9 years of two knee joint sorenesses, had Knee Trauma history and history of catching cold.Though through treatments such as Chinese medicine and western medicine pain relievings, two knee joint sorenesses still time stop when doing, recently, knee joint soreness increases the weight of, and stair activity all needs handrail, and seat erects difficulty.X takes the photograph sheet prompting: knee joint is that bone is loose, and joint space narrows.Check: tenderness (+) around two knee joints, mild swelling and limping, two knee articulation degree are limited to 45 °, have interlocking to levy, McMurray's test (+), lateroflexion (±), floating kneecap (±).Diagnosis: knee osteoarthritis.Take medicine of the present invention, every day 1 dose, after 3 courses for the treatment of, rear two knee joints are ached and are alleviated, and swelling disappears, and all the other symptoms alleviate.Continue to take 4 courses for the treatment of, recovery from illness, follow up a case by regular visits to after 1 year without recurrence.

Claims (1)

1. one kind is used for the treatment of the Chinese medicine of gonarthritis, it is characterized in that being made up of the crude drug of following weight portion: Radix aconiti szechenyiani 5 ~ 9, Passiflora wilsonii 4 ~ 7, Herba Siegesbeckiae 4 ~ 8, Herba Clinopodii megalanthi 4 ~ 7, dodder laurel 4 ~ 8, white Radix Solani Melongenae 5 ~ 8, Rhizoma Curcumae 6 ~ 9, Flos Carthami 6 ~ 9, Herba Sambuci Adnatae 7 ~ 9, Rhizoma Corydalis Decumbentis 6 ~ 9, Rhizoma Ligustici 2 ~ 5, Herba Thlaspis 6 ~ 9, Lysimachia trientaloides Hemsl. 2 ~ 5, blood outstanding person 4 ~ 6, squeezing slurry grass 2 ~ 4, Rhizoma Dioscoreae Septemlobae 4 ~ 6, Cortex berberidis dasystachyae 2 ~ 4, Radix Tylophorae arenicolae 7 ~ 9, by medicinal for above-mentioned raw materials water soaking, filtrate of removing slag after decocting to obtain.