CN103768538B - A kind of medicine for the treatment of knee osteoarthritis - Google Patents
A kind of medicine for the treatment of knee osteoarthritis Download PDFInfo
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Abstract
Treat a medicine for knee osteoarthritis, this medicine is made up of Radix seu Folium Rubi Pinfaensis, tree head dish, Radix Gentianae, Radix Cynanchi Paniculati, Weng Bo, Fructus Gardeniae, Aspongopus, Rhizoma Et Radix Notopterygii, Rhizoma Curcumae Longae, Borneolum Syntheticum.Clinical can be used for, treats knee osteoarthritis.
Description
Technical field
The invention belongs to technical field of Chinese medicines, especially relate to a kind of medicine for the treatment of knee osteoarthritis.
Background technology
Knee osteoarthritis take articular cartilage degeneration as multi-faceted, the chronic inflammatory disease at many levels, in various degree of involving sclerotin, synovial membrane, joint capsule and other structures of joint of core.Its clinical manifestation mostly is that the gonalgia, swelling, dysfunction, joint are thick, Varus deformity etc.Knee osteoarthritis mostly be old people, be the disease of deficiency in origin and excess in superficiality, the long-term lacking activity due to the gonalgia in addition, cause local QI-blood circulation not enough, muscle is become homeless foster, numbness of aching, and of a specified duration easily causes myoatrophy and osteoporosis.
Summary of the invention
The object of the present invention is to provide that a kind of therapeutic effect is good, effective percentage is high, medicine to the treatment knee osteoarthritis of human non-toxic's side effect.
The object of the present invention is achieved like this, according to Chinese medical theory, utilizing the property of medicine of Chinese medicine uniqueness, adopting Radix seu Folium Rubi Pinfaensis, tree head dish, Radix Gentianae, Radix Cynanchi Paniculati, Weng Bo, Fructus Gardeniae, Aspongopus, Rhizoma Et Radix Notopterygii, Rhizoma Curcumae Longae, Borneolum Syntheticum according to certain compatibility requirement, through being processed into.
Prepare medicine of the present invention to be made up of following raw material medicaments: Radix seu Folium Rubi Pinfaensis 40-60 part, tree head dish 30-50 part, Radix Gentianae 30-50 part, Radix Cynanchi Paniculati 20-30 part, Weng Bo 20-30 part, Fructus Gardeniae 20-30 part, Aspongopus 10-20 part, Rhizoma Et Radix Notopterygii 10-20 part, Rhizoma Curcumae Longae 10-20 part, Borneolum Syntheticum 8-12 part.
Optimum weight part of medicine material medicine of the present invention is: Radix seu Folium Rubi Pinfaensis 50 parts, tree head dish 40 parts, Radix Gentianae 40 parts, Radix Cynanchi Paniculati 25 parts, Weng Bo 25 parts, Fructus Gardeniae 25 parts, Aspongopus 15 parts, Rhizoma Et Radix Notopterygii 15 parts, 15 parts, Rhizoma Curcumae Longae, Borneolum Syntheticum 10 parts.
The pharmacological action of Chinese medicine of the present invention is as follows:
Radix seu Folium Rubi Pinfaensis: salty, cool.Return liver, kidney channel.Cooling blood for hemostasis, expelling wind and removing dampness, detoxification sore treatment.Clinical in heat in blood haematemesis, hematuria, has blood in stool, metrorrhagia, rheumatic arthritis, eczema, is with inferior disease.
Tree head dish: bitter, cold.Heat-clearing and toxic substances removing, stomach invigorating.Clinical in acute filthy disease heating, rotten skin ulcer, venom, stomachache, the diseases such as rheumatic arthritis.
Radix Gentianae: bitter, warm.Removing toxic substances, dampness.Clinical in anthrax, rheumatic arthralgia.
Radix Cynanchi Paniculati: pungent, hot, returns spleen, stomach, kidney channel.Warming middle-JIAO to relieve pain, killing parasites for relieving itching, promoting blood circulation and detoxication, detumescence.Clinical in gastropathy, toothache, rheumatic arthralgia, lumbago, epigastric pain, cholecystitis, urine water conservancy, has loose bowels, dysentery, eczema, urticaria, venom.
Weng Bo: sweet, warm.Yang invigorating is dispersed, removing toxic substances rash, dispelling wind for relieving itching.Cure mainly measles without adequate eruption, high heat, cough, parotitis, rheumatic arthritis, rubella pruritus etc.
Fructus Gardeniae: bitter, cold, GUIXIN, liver, lung, stomach warp.Clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body., sore swollen toxin unhappy for calentura.
Aspongopus: salty, warm.Return liver,kidney,spleen warp.Promoting the circulation of QI to relieve pain, warming the kidney to invigorate YANG.For incoordination between the liver and stomach, abdominal distention, lumbago, the diseases such as sexual impotence.
Rhizoma Et Radix Notopterygii: acrid, bitter, warm.Return bladder, kidney channel.Cold expelling dispels the wind, removing dampness to relieve pain.For anemofrigid cold, headache general pain, rheumatic arthralgia, shoulder aches etc.
Rhizoma Curcumae Longae: bitter in the mouth, pungent, warm in nature.Return spleen, Liver Channel.Removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.The all cards of stagnation of QI and blood, born of the same parents' abdomen hypochondriac pain, dysmenorrhes, the stagnant stomachache of the stasis of blood in puerperal, rheumatic arthralgia, traumatic injury, carbuncle etc.
Borneolum Syntheticum: pungent, bitter, cool.GUIXIN, lung meridian.To have one's ideas straightened out refreshment, heat radiation pain relieving, improving eyesight removing nebula.For apoplexy, calentura coma, deafness with qi stagnation, sore throat, aphtha, carbuncle, hemorrhoid, the diseases such as enterobiasis.
Motherland's medical science thinks that it is fallen ill and caused by liver and kidney deficiency, and cold-damp is invaded, and retardance meridians, caused by phlegm-turbidity and blood stasis blood stasis is stagnant, especially at the pathological factor that acute attack stage is very important.Radix seu Folium Rubi Pinfaensis expelling wind and removing dampness, removing toxic substances in the present invention are monarch drug; Tree head dish heat-clearing and toxic substances removing, Radix Gentianae removing toxic substances, dampness are ministerial drug; Radix Cynanchi Paniculati promoting blood circulation and detoxication, Weng Bo dispels the wind, detoxify, Fructus Gardeniae dampness removing, removing toxic substances, Aspongopus promoting the circulation of QI to relieve pain, notopterygium wind dispelling, removing dampness to relieve pain, Rhizoma Curcumae Longae circulation of qi promoting only, Borneolum Syntheticum pain relieving.Find, to knee osteoarthritis, there is unique curative effect through clinical practice, reach the object for the treatment of knee osteoarthritis.
Medicine of the present invention was in 2008 to 2011 the routine patients of clinical observation knee osteoarthritis 55, and clinical report is as follows:
1, physical data
In 55 routine patients, in age 45-76 year, the course of disease is many at 3 months to 10 years, 62 years old mean age.
2, diagnostic criteria
Draft with reference to " arthritis diagnosis and treatment draft guidelines gonarthritis in 2002 diagnostic criteria of rheumatism branch of Chinese Medical Association ":
1. nearly one month frequent gonalgia repeatedly; 2. X-ray film (erect position or Weight carrying position) joint space narrows; 3. limpid, the thickness of joint fluid (at least 2 times), WBC≤200/ml; 4. person in middle and old age person (>=40 years old); 5. knee joint deadlock in morning≤30 minutes; 6. friction sound is had during activity.Meet and 1. 2. or 3. 5. 6. or 1. 4. 5. 6. namely form diagnosis.According to sign: the 1. gonalgia, walking function obstacle, exacerbation of symptoms when fatigue and stair activity, involves periarticular muscles pain.2. health check-up knee joint is unrestrained swollen, patella and inside and outside Xiyan place tenderness+, patella grinding pain, floating patella test+, it is limited that knee joint stretches flex, atrophy of quadriceps femoris.
3, Therapeutic Method
3.1 prescriptions: Radix seu Folium Rubi Pinfaensis 50g, tree head dish 40g, Radix Gentianae 40g, Radix Cynanchi Paniculati 25g, Weng Bo 25g, Fructus Gardeniae 25g, Aspongopus 15g, Rhizoma Et Radix Notopterygii 15g, Rhizoma Curcumae Longae 15g, Borneolum Syntheticum 10g.
3.2 methods of preparation and use: said medicine routinely technique makes decoction, every day 1 dose, every day 2 times 10 days was 1 course for the treatment of.
4, therapeutic outcome:
4.1 treatment evaluation criterias, judge according to " the Chinese medical disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine formulates:
Clinical cure: knee joint swelling, pain disappear, flexion-extension motion scope recovers normal, and walking is freely;
Effective: knee joint swelling substantially disappears or obviously goes down, and pain obviously alleviates, flexion-extension motion scope is normal;
Take a turn for the better: knee joint swelling and pain all have and alleviates in various degree and alleviate, and flexion-extension motion scope is also improved;
Invalid: knee joint swelling and pain are all without alleviation.
4.2 results: in 55 routine patients, clinical cure 31 example (56.4%), effective 11 examples (20%), 9 examples that take a turn for the better (16.4%), invalid 4 examples (7.2%), total effective rate is 92.8%.
Model case
1, Zhao, man, 59 years old, nearly 1 year of two gonalgia, over nearly 1 month, right swelling and pain in knee obviously increased the weight of, and above all needs staircase downstairs, seat dysstasia, and meet overcast and rainy symptom obviously, morning is stiff, occasionally has interlocking phenomenon.Check: inner side tenderness under kneecap: left knee joint (+), right knee joint (++); Right knee joint is micro-swollen, right Range of motion of knee joint: 45 °; Tongue is greasy in vain, stringy and rolling pulse.Diagnosis: knee osteoarthritis.Take medicine of the present invention, treat 2 courses for the treatment of, two swelling and pain in knee obviously alleviate, and all the other symptoms also in alleviation trend, continue to take 3 courses for the treatment of, and recovery from illness is followed up a case by regular visits to after half a year without recurrence.
2, Lee, female, 68 years old, existing 15 years of two knee joint sorenesses, had Knee Trauma history and history of catching cold.Though through treatments such as Chinese medicine and western medicine pain relievings, two knee joint sorenesses still time stop when doing, recently, knee joint soreness increases the weight of, and stair activity all needs handrail, and seat erects difficulty.X takes the photograph sheet prompting: knee joint is that bone is loose, and joint space narrows.Check: tenderness (+) around two knee joints, mild swelling and limping, two knee articulation degree are limited to 45 °, have interlocking to levy, McMurray's test (+), lateroflexion (±), floating kneecap (±).Diagnosis: knee osteoarthritis.Take medicine of the present invention, every day 1 dose, after 3 courses for the treatment of, rear two knee joints are ached and are alleviated, and swelling disappears, and all the other symptoms alleviate.Continue to take 4 courses for the treatment of, recovery from illness, follow up a case by regular visits to after 1 year without recurrence.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, and this embodiment following does not only limit the present invention for illustration of the present invention.
Embodiment 1, a kind of medicine for the treatment of knee osteoarthritis is made up of Radix seu Folium Rubi Pinfaensis 40g, tree head dish 30g, Radix Gentianae 30g, Radix Cynanchi Paniculati 20g, Weng Bo 20g, Fructus Gardeniae 20g, Aspongopus 10g, Rhizoma Et Radix Notopterygii 10g, Rhizoma Curcumae Longae 10g, Borneolum Syntheticum 8g.
Embodiment 2, a kind of medicine for the treatment of knee osteoarthritis is made up of Radix seu Folium Rubi Pinfaensis 50g, tree head dish 40g, Radix Gentianae 40g, Radix Cynanchi Paniculati 25g, Weng Bo 25g, Fructus Gardeniae 25g, Aspongopus 15g, Rhizoma Et Radix Notopterygii 15g, Rhizoma Curcumae Longae 15g, Borneolum Syntheticum 10g.
Embodiment 3, a kind of medicine for the treatment of knee osteoarthritis is made up of Radix seu Folium Rubi Pinfaensis 60g, tree head dish 50g, Radix Gentianae 50g, Radix Cynanchi Paniculati 30g, Weng Bo 30g, Fructus Gardeniae 30g, Aspongopus 20g, Rhizoma Et Radix Notopterygii 20g, Rhizoma Curcumae Longae 20g, Borneolum Syntheticum 12g.
Claims (2)
1. treat a medicine for knee osteoarthritis, it is characterized in that it is made up of following raw material medicaments:
Radix seu Folium Rubi Pinfaensis 40-60 part, tree head dish 30-50 part, Radix Gentianae 30-50 part, Radix Cynanchi Paniculati 20-30 part, Weng Bo 20-30 part, Fructus Gardeniae 20-30 part, Aspongopus 10-20 part, Rhizoma Et Radix Notopterygii 10-20 part, Rhizoma Curcumae Longae 10-20 part, Borneolum Syntheticum 8-12 part.
2. medicine according to claim 1, is characterized in that it is made up of following raw material medicaments:
Radix seu Folium Rubi Pinfaensis 50 parts, tree head dish 40 parts, Radix Gentianae 40 parts, Radix Cynanchi Paniculati 25 parts, Weng Bo 25 parts, Fructus Gardeniae 25 parts, Aspongopus 15 parts, Rhizoma Et Radix Notopterygii 15 parts, 15 parts, Rhizoma Curcumae Longae, Borneolum Syntheticum 10 parts.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1196948A (en) * | 1998-03-04 | 1998-10-28 | 刘煌清 | Full presciption medicine for treating rheumatism disease |
| CN101721537A (en) * | 2009-12-25 | 2010-06-09 | 黄毅 | Traditional Chinese medicine for treating rheumatic and rheumatoid arthritis |
| CN102178759A (en) * | 2011-04-21 | 2011-09-14 | 张庆珍 | Traditional Chinese medicine composition for treating rheumatism and preparation method of composition |
| CN102727833A (en) * | 2012-07-12 | 2012-10-17 | 李琦 | Plaster for treating rheumatoid bone disease |
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2014
- 2014-02-24 CN CN201410061359.XA patent/CN103768538B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1196948A (en) * | 1998-03-04 | 1998-10-28 | 刘煌清 | Full presciption medicine for treating rheumatism disease |
| CN101721537A (en) * | 2009-12-25 | 2010-06-09 | 黄毅 | Traditional Chinese medicine for treating rheumatic and rheumatoid arthritis |
| CN102178759A (en) * | 2011-04-21 | 2011-09-14 | 张庆珍 | Traditional Chinese medicine composition for treating rheumatism and preparation method of composition |
| CN102727833A (en) * | 2012-07-12 | 2012-10-17 | 李琦 | Plaster for treating rheumatoid bone disease |
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Effective date of registration: 20231208 Address after: 226000 Qidong Binjiang fine chemical industry park, Nantong City, Jiangsu Province Patentee after: Qidong Binhua water supply Co.,Ltd. Address before: 226000, No.78 Jiangsu Road, Binjiang Fine Chemical Industrial Park, Qidong City, Nantong City, Jiangsu Province Patentee before: Nantong Fayink High-tech Material Technology Co.,Ltd. |