CN103599501B - A kind of Chinese medicine composition being used for the treatment of ankylosing spondylitis - Google Patents

Abstract

A kind of Chinese medicine composition being used for the treatment of ankylosing spondylitis, relate to field of Chinese herbal medicine technology, take each taste crude drug by following weight: Radix Glycyrrhizae Preparata 20g, Radix Angelicae Pubescentis 20g, Radix Rehmanniae Preparata 25g, Herba Cistanches 25g, Cortex Cinnamomi 25g, Rhizoma Zingiberis 30g, Rhizoma Curculiginis 25g, Radix Saposhnikoviae 24-2625g, Radix Dipsaci 25g, Herba Asari 25g, Rhizoma Et Radix Notopterygii 25g, Caulis Piperis Kadsurae 30g, Zaocys 25g, Pheretima 20g, Herba Epimedii 30g, Rhizoma Chuanxiong 25g, Cortex Eucommiae 25g, Radix Aconiti Lateralis Preparata 25g, Rhizoma Cibotii 30g, parasitic 30g, Squama Manis 30g, Scorpio 30g, Bombyx Batryticatus 30g.The present invention draws materials easily, make the features such as simple, with low cost, practicality is good, and taking dose is little, and Harmful ingredient content is low, has no side effect, evident in efficacy.

Description

A kind of Chinese medicine composition being used for the treatment of ankylosing spondylitis

Technical field

The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine composition being used for the treatment of ankylosing spondylitis.

Background technology

Ankylosing spondylitis (AS) is that one mainly invades spinal column, and can involve the chronic progressive external inflammatory diseases of sacroiliac joint and periarticular in various degree.It is one group of disease having common Clinical symptoms that primary disease has another name called, previously be called SpA or seronegative spondyloanthropathy, comprise AS, reactive arthritis, psoriatic arthritis, inflammatory bowel disease arthritis, spondyloarthopathies and undifferentiated type SpA, this group disease HLA-B27 gene masculine rate is high, there is Familial aggregation phenomenon, involve axis and the joint based on lower limb, have Enthesitis and some distinctive extra-articular manifestations, this group disease all may develop into AS gradually.

Summary of the invention

It is high that technical problem to be solved by this invention is to provide a kind of cure rate, the safe and reliable Chinese medicine composition being used for the treatment of ankylosing spondylitis.

Technical problem to be solved by this invention realizes by the following technical solutions:

Be used for the treatment of a Chinese medicine composition for ankylosing spondylitis, the medicament be made up of the crude drug of following weight,

The preferred weight of each crude drug is:

Crude drug used by the present invention can be bought from common Chinese shop and obtain, and its specification meets national Chinese crude drug standard.

Chinese medicine composition of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., the conventional oral formulations of any one is prepared into the method for Chinese medicinal of routine, wherein, described oral formulations can be decoction, pill, capsule or tablet.

Another object of the present invention is to provide a kind of method preparing the present composition, comprises the steps,

1) each crude drug is taken by prescription weight;

2) by above-mentioned each taste raw mill powdering, with Mel furnishing ball.

Usage and consumption:

The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as the age of patient, body weight, health status.There is invigorating the liver and kidney, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, dispel the wind, effect of removing obstruction in the collateral to relieve pain.

Instruction: get a secondary Chinese medicine, grind as end, use Mel 300g, be combined into ball, every ball as Semen phaseoli radiati size, each serving 6-8g, three times on the one.Be used for the treatment of early, mid-term ankylosing spondylitis, the half a year course for the treatment of, clinical cure.

Complementary therapy:

1, needle-knife solution, decompression treatment;

2, Drug therapy: (1) non-steroidal drug, as: Indomethacin Suppository diclofenac sodium celecoxib; (2) immunomodulator, as: sulfasalazine; (3) analgesic and muscle relaxant, as: pentazocine, strong pain pyridine Nefopam (4) anti-folic acid class medicine, as: methotrexate

3, functional exercise (flying swallow point ability of swimming).

4, avoid suffering from cold, avoiding tobacco and wine

Pharmacology analysis:

Radix Glycyrrhizae Preparata:

[property of medicine] is sweet, flat.GUIXIN, lung, spleen, stomach warp.

[effect] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

[pharmacological action] Radix Glycyrrhizae eliminating phlegm and relieving cough, arrhythmia, blood fat reducing, cholesterol reducing, antiplatelet aggregation, resisting pathogenic microbes; Anti-peptic ulcer, anti-enterospasm; There is protecting the liver, ease pain, antipyretic, sedation.

Radix Angelicae Pubescentis:

[property of medicine] is pungent, bitter, tepor.Return kidney, urinary bladder channel.

[effect] wind-damp dispelling, pain relieving, induces sweat.

[pharmacological action] Radix Angelicae Pubescentis has antiinflammatory, analgesia and sedation; Inhibitory action is had to platelet aggregation.

Radix Rehmanniae Preparata:

[property of medicine] is sweet, tepor.Return Liver and kidney warp.

[effect] enriches blood yin nourishing, life essence-filling, marrow-benefitting.

The key medicine that [pharmacological action] this product is the tonify deficiency that nourishes blood.

Herba Cistanches:

[property of medicine] sweet acid is salty, temperature.Enter kidney, large intestine, spleen, liver, urinary bladder channel.

[effect] reinforcing the kidney and supporting YANG, loosening bowel to relieve constipation, hard masses softening and resolving.

[pharmacological action] for insufficiency of kidney-YANG, the soreness of the waist and knees of menses virtual loss, muscles and bones is unable; Energy kidney-replenishing, benefiting essence-blood, warm waist knee joint.

Cortex Cinnamomi:

[property of medicine] is pungent, sweet, heat.Return spleen, kidney, conscience warp.

It is supporing yang that [effect] mends fire, dispersing cold for relieving pain, warming the meridian and promoting blood circulation.

[pharmacological action], for the weak sexual impotence cold womb of kidney yang, dyspnea due to deficiency cardiopalmus, trusted subordinate's cold type of pain, colic of cold type is had a pain, arthralgia due to cold lumbago, the thoracic obstruction, carbuncle of yin nature.Amenorrhea, dysmenorrhea.

Rhizoma Zingiberis:

[property of medicine] is pungent, heat.Return taste kidney cardiopulmonary warp.

[effect] warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warming the lung to resolve fluid-retention.

[pharmacological action] Rhizoma Zingiberis extract has the effect of calmness, analgesia, antiinflammatory, preventing or arresting vomiting.

Rhizoma Curculiginis:

[property of medicine] is pungent, hot.Poisonous.Return kidney,liver,spleen warp.

[effect] warming the kidney to invigorate YANG, bone and muscle strengthening, dispelling cold and dampness.

[pharmacological action] for insufficiency of kidney-YANG, the sexual impotence cold sperm of decline of the fire from the gate of life, enuresis frequent micturition; Waist knee joint of suffering from a deficiency of the kidney withers soft, muscles and bones cold type of pain, or chronic arthralgia caused by cold-damp; The coldness and pain in the epigastrium of deficiency of spleen-YANG and kidneyYANG, has loose bowels.

Radix Saposhnikoviae:

[property of medicine] is pungent, sweet, tepor.Return bladder, liver, kidney channel.

[effect] expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.

[pharmacological action] this product has antipyretic, antiinflammatory, calmness, analgesia, convulsion, anti-allergic effects.Certain antibacterial action is had to bacillus pyocyaneus and staphylococcus aureus.

Radix Dipsaci:

[property of medicine] is bitter, sweet, pungent, tepor.Return liver, kidney channel.

[effect] invigorating the liver and kidney, bone and muscle strengthening, arresting bleeding and miscarriage prevention, continuous folding of curing the wound.

[pharmacological action] for deficiency of the liver and kindey, lumbago flaccidity of the lower limbs, rheumatic arthralgia, and injury from falling down, fracture, swell and ache; Liver and kidney is weak, the fetal movement of Chong and Ren channel disorder for pendant or metrorrhagia through many etc.

Herba Asari:

[property of medicine] is pungent, temperature.Slightly poisonous.Return lung, kidney, heart channel.

[effect] expelling wind and cold, sensible, pain relieving, warming the lung to resolve fluid-retention.

[pharmacological action] for anemofrigid cold, sexual impotence diseases caused by exogenous pathogenic factor; Headache, toothache, arthralgia pain.

Rhizoma Et Radix Notopterygii:

[property of medicine] is pungent, bitter, temperature.Return bladder, kidney channel.

[effect] induces sweat heat radiation, expelling wind and dampness, pain relieving.

[pharmacological action] Rhizoma Et Radix Notopterygii injection has analgesia and refrigeration function, and has inhibitory action to dermatophytes, Brucella.Volatile oil also has antiinflammatory, analgesia, refrigeration function.

Caulis Piperis Kadsurae:

[property of medicine] is pungent, bitter, tepor.Return Liver Channel.

[effect] wind-damp dispelling, removing obstruction in the collateral to relieve pain.

[pharmacological action] Caulis Piperis Kadsurae energy induced by endotoxin is suffered a shock; Can antagonism thrombosis, extend clotting time.

Zaocys:

[property of medicine] is sweet, flat.Return Liver Channel.

[effect] dispelling wind and removing obstruction in the collateral, arresting convulsion relieving convulsion.

[pharmacological action] is for rheumatic arthralgia; Dry exudative dermatitis card; Tetanus, the anxious chronic infantile convulsion of children's, spasm is twitched.

Pheretima:

[property of medicine] is salty, cold.Return liver spleen, urinary bladder channel.

[effect] clearing heat for calming endogenous wind, dredging collateral, relievings asthma, diuresis.

[pharmacological action] this product has good refrigeration function, has calm anticonvulsant action, and Pheretima can also strengthen the effects such as immunity, antitumor, antibacterial, diuresis.

Herba Epimedii:

[property of medicine] acrid, sweet, warm.Return liver, kidney channel

[effect] kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.

[pharmacological action] is soft for impotence due to deficiency of the kidney, seminal emission premature ejaculation, waist knee joint flaccidity, cold extremities with aversion to cold; Arthralgia due to cold-dampnes or spasm of the limbs numbness.Dispelling the wind and dampness pathogens arthralgia pain is partial to cold-damp person, and numb limbs and tense tendons is meciless or muscles and bones contracture etc.

Rhizoma Chuanxiong:

[property of medicine] is pungent, temperature.Return liver, gallbladder, pericardium channel.

[effect] blood-activating and qi-promoting, wind-expelling pain-stopping.

The expansible blood vessel of [pharmacological action] Rhizoma Chuanxiong, improves microcirculation; Can surface activity of blood platelet be reduced, suppress platelet aggregation, the formation of pre-preventing thrombosis.There is calm effect, and have obvious and lasting hypotensive effect; The absorption of fracture local hematoma can be accelerated, promote the formation of callus; Various bacteria can be suppressed.

The Cortex Eucommiae:

[property of medicine] is sweet, warm.Return liver, kidney channel.

[effect] invigorating the liver and kidney, bone and muscle strengthening, antiabortive.

[pharmacological action] for the soreness of waist and knee joint of deficiency of the liver and kindey, flaccidity and weakness of the lower limbs and sexual impotence, frequent micturition; Caused by liver and kidney deficiency, the gestation hemorrhage of below element deficiency and cold, frequent fetal movement or habitual abortion; Reduce blood pressure.

Radix Aconiti Lateralis Preparata:

[property of medicine] is pungent, sweet, heat.Poisonous.GUIXIN, kidney, spleen channel.

[effect] recuperating depleted YANG and rescuing the patient from collapse, supporing yang benefit fire, dispersing cold for relieving pain.

[pharmacological action] for yang depletion syndrome, the sexual impotence cold womb of deficient cold type, coldness and pain in the epigastrium, has loose bowels, edema; Arthralgia due to cold disease.

Rhizoma Cibotii:

[property of medicine] is bitter, sweet, temperature.Return liver, kidney channel.

[effect] wind-damp dispelling, invigorating the liver and kidney, strong waist knee joint.

[pharmacological action], for rheumatic arthralgia, lumbago back rigidity, can not pitching, and sufficient knee joint is weak; The enuresis of instability of kidney QI, leukorrhagia.

Parasitic:

[property of medicine] bitter, sweet, flat.Return liver, kidney channel.

[effect] wind-damp dispelling, liver and kidney tonifying, bone and muscle strengthening, antiabortive.

[pharmacological action] rheumatic arthralgia, soreness of waist and knee joint; Invigorating the liver and kidney, to nourish blood.

Squama Manis:

[property of medicine] is salty, is slightly cold.Return liver, stomach warp.

[effect] to be invigorated blood circulation Xiao Disorder, is stimulated the menstrual flow, stimulating milk secretion, detumescence and apocenosis.

[pharmacological action] Yu mass in the abdomen, amenorrhea, and rheumatic arthralgia.Carbuncle sore tumefacting virus, scrofula.

Scorpio:

[property of medicine] is pungent, flat.Poisonous.Return Liver Channel.

[effect] endogenous wind stopping relieving convulsion, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.

[pharmacological action] twitches for spasm, sore swollen toxin; Rheumatism plays numbness, intractable migraine and general headache.

Bombyx Batryticatus:

[property of medicine] is salty, pungent, flat.Return liver, lung meridian.

[effect] endogenous wind stopping relieving convulsion, wind-expelling pain-stopping, dissipating phlegm and resolving masses.

[pharmacological action] twitches for infantile convulsion, wind apoplex involving the channels and collaterals, headache due to pathogenic wind-heat, conjunctival congestion, pharyngeal swelling or rubella pruritus.

Medicated diet prepared by the present invention has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and disease therapy, drops into the use link of disease therapy provide science and objective foundation to this medicine.Its test method and result of the test are distinguished as follows:

1. the medicated diet that prepared by couple the present invention carries out animal acute toxicity test:

Medicine: grind to form powdery by prescription of the present invention, furnishing pasty state;

Experimental animal: white mice, body weight is at 30-50g, and male and female Stochastic choice, is provided by Medical University Of Anhui.

Method and result: get white mice 50, be divided into 5 groups, often organize 10, hungry 15 hours, fill with medicine feed thing by every only each 2g, in 24 hours, fill with medicine feed thing respectively 1,2,3,4,5 times for the 1st, 2,3,4,5 group, observe 5 days, white mice is movable normal, non-toxic reaction, without dead.Wherein white mice dosage is by kg body weight medicine calculation, shows that oral liquid is without acute toxicity, clinical medicine dose safety.

2. the medicated diet that prepared by couple the present invention carries out long-term toxicity test for animals:

Experimental animal: rat, body weight, at 120-130g, all selects male white rat, is provided by Medical University Of Anhui.

Method and result: get rat 50, be divided into 5 groups, often organize 10, wherein the 1st, 2, 3, 4 groups as administration group, often organize and fill with medicine feed thing 1g respectively, 2g, 3g, 4g, 5th group of diet as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the change of tissues observed form, observe the effect of dosage, observe diet, movable change, experiment proves that administration group compares without significant change with matched group, visible by the dosage equal non-toxic reaction of kg body weight calculating relative to clinical 50-200 times, a kind of safe drugs.

3. diagnostic criteria

This prescription, in clinical practice, cures patient more than 600 example, and carries out long-term tracking and pay a return visit, patient's clinical symptom remission after the half a year that finds to adhere to take medicine, and function limitation obviously improves; After adhering to taking medicine 1 year patient early, mid-term motor function normal, clinical symptom disappearance.

In order to verify clinical efficacy, this prescription is tried out in The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine and Jieshou City institute of traditional Chinese medicine respectively, and by random selecting wherein 100 routine patients, the course for the treatment of is the shortest 60 days, and the longest is 1 year.

Therapeutic Method: according to drug ratios of the present invention, takes raw material (dose), obtains pill according to the method for conventional formulation, every day 6-8g, the morning, noon and afternoon service once.

Efficacy determination: adopt four grade standards;

Recovery from illness clinical improvements rate >=10%, effective clinical improvements rate >=52%, effective clinical improvement rate >=36%, invalid clinical improvements rate >=2%, concrete therapeutic outcome is see table 1.

Table 1

Number of cases	Recovery from illness	Effective	Effectively	Invalid	Effective percentage (%)
						100	10	52	36	2	98

Points for attention:

1. diet should be light, gives up alcohol and pungent, raw and cold, greasy food.

2. child, women breast-feeding their children, elderly and infirm should take under doctor instructs.

3. driver, work high above the ground person are cautious use of.

4. strictly take by usage and dosage.

5. pair this medicine and alcohol intolerance person forbidding, allergic constitution person be cautious use of.

6. prohibit the use when this property of drug changes.

7. please this medicine is placed on the place that child can not contact.

8. as used other medicines, please Ref Dr or pharmacist before using this medicine.

The invention has the beneficial effects as follows: the present invention draws materials easily, make the features such as simple, with low cost, practicality is good, and taking dose is little, and Harmful ingredient content is low, has no side effect, evident in efficacy.

Detailed description of the invention

The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.

Embodiment 1

Be used for the treatment of a Chinese medicine composition for ankylosing spondylitis, take each taste crude drug by following weight: Radix Glycyrrhizae Preparata 19g, Radix Angelicae Pubescentis 19g, Radix Rehmanniae Preparata 24g, Herba Cistanches 24g, Cortex Cinnamomi 24g, Rhizoma Zingiberis 29g, Rhizoma Curculiginis 24g, Radix Saposhnikoviae 24g, Radix Dipsaci 24g, Herba Asari 24g, Rhizoma Et Radix Notopterygii 24g, Caulis Piperis Kadsurae 29g, Zaocys 24g, Pheretima 19g, Herba Epimedii 29g, Rhizoma Chuanxiong 24g, Cortex Eucommiae 24g, Radix Aconiti Lateralis Preparata 24g, Rhizoma Cibotii 29g, parasitic 29g, Squama Manis 29g, Scorpio 29g, Bombyx Batryticatus 29g.Said medicine is ground as end, gets Mel 300g, be combined into ball.Each serving 6g, three times on the one.Treatment early, mid-term ankylosing spondylitis, the half a year course for the treatment of clinical cure.

Embodiment 2

Be used for the treatment of a Chinese medicine composition for ankylosing spondylitis, take each taste crude drug by following weight: Radix Glycyrrhizae Preparata 21g, Radix Angelicae Pubescentis 21g, Radix Rehmanniae Preparata 26g, Herba Cistanches 26g, Cortex Cinnamomi 26g, Rhizoma Zingiberis 31g, Rhizoma Curculiginis 26g, Radix Saposhnikoviae 26g, Radix Dipsaci 26g, Herba Asari 26g, Rhizoma Et Radix Notopterygii 26g, Caulis Piperis Kadsurae 31g, Zaocys 26g, Pheretima 21g, Herba Epimedii 31g, Rhizoma Chuanxiong 26g, Cortex Eucommiae 26g, Radix Aconiti Lateralis Preparata 26g, Rhizoma Cibotii 31g, parasitic 31g, Squama Manis 31g, Scorpio 31g, Bombyx Batryticatus 31g.Said medicine is ground as end, gets Mel 300g, be combined into ball.Each serving 6g, three times on the one.Treatment early, mid-term ankylosing spondylitis, the half a year course for the treatment of clinical cure.

Embodiment 3

Be used for the treatment of a Chinese medicine composition for ankylosing spondylitis, take each taste crude drug by following weight: Radix Glycyrrhizae Preparata 20g, Radix Angelicae Pubescentis 20g, Radix Rehmanniae Preparata 25g, Herba Cistanches 25g, Cortex Cinnamomi 25g, Rhizoma Zingiberis 30g, Rhizoma Curculiginis 25g, Radix Saposhnikoviae 24-2625g, Radix Dipsaci 25g, Herba Asari 25g, Rhizoma Et Radix Notopterygii 25g, Caulis Piperis Kadsurae 30g, Zaocys 25g, Pheretima 20g, Herba Epimedii 30g, Rhizoma Chuanxiong 25g, Cortex Eucommiae 25g, Radix Aconiti Lateralis Preparata 25g, Rhizoma Cibotii 30g, parasitic 30g, Squama Manis 30g, Scorpio 30g, Bombyx Batryticatus 30g.Said medicine is ground as end, gets Mel 300g, be combined into ball.Each serving 8g, three times on the one.Treatment early, mid-term ankylosing spondylitis, the half a year course for the treatment of clinical cure.

Prescribed treatment ankylosing spondylitis medical record citing (case derives from Jieshou City pain disease institute) of the present invention:

Case 1

Liu, man, 34 years old, peasant.In December, 2010 is gone to a doctor because of " bilateral sacroiliac joint aches more than 2 years, increases the weight of January ".Patient is uncomfortable without bilateral sacroiliac joint pain conscious under obvious inducement before 2 years, and night increases the weight of, and does not affect normal work and life, does not give attention at that time, and do not do special handling.Before January, after patient's fatigue, self-induction bilateral sacroiliac joint pain increases the weight of, and pain is to be night very, and limitation of activity, having a rest to have no alleviates, and bilateral sacroiliac joint pain Progressive symmetric erythrokeratodermia increases the weight of then, to our hospital.

Have a medical check-up: lower back, sacroiliac joint limited range of motion, tenderness, percussion pain (+), local skin has no obvious redness, heating, and bilateral is bent hip and to be gone down on one's knees test (+), 4 words test (+), remaining (-).Take the photograph DR to show: bilateral sacroiliitis; HLA-B27 (+).Intend accepting for medical treatment with " ankylosing spondylitis ".

While in hospital gives bilateral sacroiliac joint, waist needle-knife solution art, and coordinate massage, Chinese medicine fumigation and washing, the fluid infusion of Chinese medicine and western medicine antiinflammatory, invigorating the liver and kidney, bone and muscle strengthening, removing obstruction in the collateral to relieve pain anti symptom treatment, give ridge ball alive when leaving hospital and grind as end, Mel 300g, is combined into ball.Each serving 6g, three times on the one.And advise its suitable functional exercise.

Patient's clinical symptom remission after half a year, function limitation obviously improves.After continuing to take medicine 1 year, patient's lower back, sacroiliac joint activity are normal, clinical symptom disappearance.

Case 2

Zhang, man, 24 years old, student.In January, 2012 because of " lower back stiff, pain half a year, increase the weight of February " medical.Without occurring under obvious inducement that back is stiff, ache before patient half a year, night increases the weight of.Once in Langxi County institute of traditional Chinese medicine with " ankylosing spondylitis " treatment (specifically not quite clear), after slightly alleviate, but have that lower back is stiff, pain symptom always.

Before nearly February, after patient's fatigue, stiff, the pain of self-induction lower back increases the weight of, and right side sacroiliac joint aches, and night, impact sleep, today to our hospital, looks into HLA-B27 prompting: positive, outpatient service through look into intend with: " ankylosing spondylitis " is hospitalized and is admitted to hospital.

Have a medical check-up: lower back activity is obviously limited, tenderness, percussion pain (+), right side sacroiliac joint tenderness (+), local skin has no obvious heating, swelling.Hip in the wrong of going down on one's knees test (+), 4 words test (+).

While in hospital gives local needle-knife solution art, functional exercise, massage physical therapy, electrical excitation treatment, Chinese medicine and western medicine invigorating the liver and kidney, bone and muscle strengthening, removing obstruction in the collateral to relieve pain, blood circulation promoting and blood stasis dispelling, Psoralen keep fit anti symptom treatment.And give ridge ball alive and grind as end, Mel 300g, is combined into ball.Each serving 8g, three times on the one.

After 2 months patient's low-back pain comparatively before take a turn for the better, limitation of activity obviously improves, and after continuing to take medicine 6 months, normal patient movement is not limited, clinical symptom disappearance.

Case 3

Jin so-and-so, man, 19 years old, Out-migrant for work.In November, 2009 is because " waist and sacrum pain more than 2 years, increases the weight of March." medical.There is waist and sacrum pain without under obvious inducement before 2 years in patient, activity postemphasis, and remission after having a rest, does not pay attention to always.Conditions of patients recurrent exerbation between 2 years, long-term to relieve the pain medicine relief of symptoms from clothes, once in other places with " ankylosing spondylitis " hospitalization, concrete medication is not quite clear, and symptom is gone home after slightly alleviating recuperation.

Before March, after patient's fatigue, self-induction waist and sacrum pain increases the weight of, left side hip pain, take night as work, limitation of activity, the oral drug symptom that relieves the pain is not improved, and the present is further after treatment, to our hospital, outpatient service intend with: " ankylosing spondylitis " is hospitalized and is admitted to hospital.

Have a medical check-up: lumbosacral region limitation of activity, tenderness, percussion pain (+), left hip limitation of activity, hip in the wrong of going down on one's knees test (+), local tenderness (+), left side " 4 " word experiment (+), local skin has no obvious heating, swelling.DR shows: both sides sacroiliac joint surface is fuzzy, crude, irregular; Juxtra-articular osteoporosis, is shown in mottled and little cystic bone destruction district and a little hyperostosis osteosclerosis shadow; Joint space has no narrow; Soft tissue has no swelling; Other: no abnormality seen.

While in hospital gives needle-knife solution art, and gives the scheme process such as massage physical therapy, herbal fumigation, Chinese and western drugs blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney, bone and muscle strengthening, removing obstruction in the collateral to relieve pain, blood circulation promoting and blood stasis dispelling, and improvement is left hospital.Giving Yu Shi bolus for reinforcing bones of human body grinds as end, and Mel 300g, is combined into ball.Each serving 6g, three times on the one.

Follow up a case by regular visits to after half a year, patient's waist and sacrum pain is alleviated, and still have pain when left hip is movable, function is obviously improved, and after taking medicine 1 year, the left hip pain of patient is alleviated, and mobility is normal, clinical symptom disappearance.

Case 4

Slowly so-and-so, male, 31 years old, peasant, because " stiff 4 years of chest and back, flank pain, increase the weight of 1 week " goes to a doctor.Patient's 4 years causes are without occurring under obvious inducement that chest and back, flank pain are stiff, and night increases the weight of, and does not affect orthobiosis, patient does not draw attention, and in local clinic oral administration Western medicine and externally applied ointment treatment, symptom takes a turn for the better to some extent, but can not be thorough, heavy time light during the state of an illness.In the past few years patient does manual work in other places for a long time, once treated with " ankylosing spondylitis " in outer court, symptom is slightly alleviated, but there are chest and back, flank pain always, nearly 2 years always oral, the medicine symptomatic treatments such as sulfasalazine, Ying Taiqing, the order of first ammonia butterfly, and before 1 week, patient's above-mentioned symptom increases the weight of suddenly, and today to our hospital, intend " ankylosing spondylitis " and accept for medical treatment through looking into outpatient service and be admitted to hospital.

Have a medical check-up: chest and back is stiff, tenderness, percussion pain (+).Waist tenderness, percussion pain (+), two lower limb leg raising straight experiment (-), strengthens experiment (-), bilateral buttocks tenderness (+), " 4 " word test (+), and muscular strength and muscular tension are all normal, remaining (-).AP roentgenograms shows: sacroiliitis sexually revises.

Give after patient admits back and bilateral buttocks pin cutter treatment and the fluid infusion of Chinese medicine and western medicine antiinflammatory, invigorating the liver and kidney, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain anti symptom treatment.When leaving hospital, pain, limitation of activity are alleviated substantially.Giving ridge ball alive grinds as end, and Mel 300g, is combined into ball.Each serving 8g, three times on the one.And coordinate functional exercise auxiliary treatment.

Check after half a year, patient chest back, flank pain are alleviated substantially, the malaise symptoms such as limitation of activity disappears substantially.Continue to take medicine and heighten the effect of a treatment for 1 year, follow up a case by regular visits to symptom after 1 year without recurrence.

More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.

Claims (5)

1. be used for the treatment of a Chinese medicine composition for ankylosing spondylitis, it is characterized in that, the medicament be made up of the crude drug of following weight:

2. a kind of Chinese medicine composition being used for the treatment of ankylosing spondylitis according to claim 1, is characterized in that, the medicament be made up of the crude drug of following weight:

3. a kind of Chinese medicine composition being used for the treatment of ankylosing spondylitis according to claim 1 and 2, is characterized in that: described medicament is the preparation that any one is suitable for clinically.

4. a kind of Chinese medicine composition being used for the treatment of ankylosing spondylitis according to claim 3, is characterized in that: described preparation is oral formulations.

5. a kind of Chinese medicine composition being used for the treatment of ankylosing spondylitis according to claim 4, is characterized in that: described oral formulations is pill.