CN103550446A - Traditional Chinese medicine composition for external use to treat rheumatoid arthritis and application of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for external use to treat rheumatoid arthritis and application of traditional Chinese medicine composition Download PDF

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CN103550446A
CN103550446A CN201310531511.1A CN201310531511A CN103550446A CN 103550446 A CN103550446 A CN 103550446A CN 201310531511 A CN201310531511 A CN 201310531511A CN 103550446 A CN103550446 A CN 103550446A
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rheumatoid arthritis
chinese medicine
medicine composition
traditional chinese
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CN103550446B (en
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董春玲
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Zhong Danzhu
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杨献华
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Abstract

The invention discloses a traditional Chinese medicine composition for external use to treat rheumatoid arthritis, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for the external use to treat the rheumatoid arthritis is prepared from the following Chinese herbal medicines in parts by weight: 30-50 parts of tangerine leaf, 30-50 parts of garden balsam stem, 15-22 parts of rhizoma acori graminei, 6-10 parts of euphorbia pekinensis, 40-80 parts of ramulus mori and 40-80 parts of willow branch. The traditional Chinese medicine composition for the external use to treat the rheumatoid arthritis, which is disclosed by the invention, has the effects of expelling wind, clearing away cold, eliminating dampness, dredging channels, activating blood to promote menstruation, and promoting qi circulation to relieve pain, and has a remarkable curative effect of treating the rheumatoid arthritis.

Description

A kind of Chinese medicine composition of external curing rheumatoid arthritis and application thereof
Technical field
The present invention relates to a kind of Chinese medicine composition and application thereof of external curing rheumatoid arthritis, relate in particular to a kind of Chinese medicine composition of fumigation treatment rheumatoid arthritis, belong to technical field of Chinese medicines.
Background technology
Rheumatoid arthritis (RA) is a kind of autoimmune disease that chronic, symmetry, polyarthritis be main clinical manifestation of take.Have saying of " not dead cancer ", its prevalence is about 0.3%~O.4%.Become the great killer of people's free living.The mechanism of current western medical treatment rheumatoid arthritis is mainly analgesia, antiinflammatory, analgesic etc., but, use Western medicine conventionally can not stop PD, can not realize healing, more seriously, its side effect is quite large, and as gastrointestinal untoward reaction, adrenal cortex underactivity, osteoporosis, aseptic osteonecrosis etc., these toxic and side effects are even even more serious than rheumatoid arthritis itself.
Motherland's medical science is referred to as arthromyodynia.< < Plain Questions numbness opinion > > day: " wet three gas of wind and cold are mixed extremely; combined into numbness; therefore; ailment said due to cold or exposure, damp, cold-evil are pathogenic direct factors; wind makes the injury of tendon and muscle; wet and cause BI-syndrome located in muscle, and meridians impatency causes QI-blood circulation freely not fallen ill.Rheumatoid Arthritis with Traditional Chinese Medicine has a long history, all on the books in many classical documents, and herbal fumigation is the combined effect of borrowing heating power and medicine to control, and by skin expansion tiny blood vessels, accelerates blood circulation, from outward appearance to inner essence, and in warm middle enforcement treatment.And skin is the organ of human body maximum, there is the several functions such as secretion, absorption, infiltration, excretion, sensation.Herbal fumigation is exactly the physiological property of utilizing skin, and medicine is absorbed by skin surface, thereby enters the effect that blood circulation reaches treatment.
Summary of the invention
The object of the invention is to by prescription again after Chinese medicine pharmacology is studied Chinese medicine composition and the medical usage of the treatment rheumatoid arthritis that provide a kind of short treating period, determined curative effect, has no side effect.
The object of the present invention is achieved like this:
The Chinese medicine composition of a kind of external curing rheumatoid arthritis of the present invention, described compositions is prepared from by the Chinese crude drug of following weight proportion: Folium Citri tangerinae 30-50 part, Herba speranskiae tuberculatae 30-50 part, Rhizoma Acori Graminei 15-22 part, Radix Euphorbiae Pekinensis 6-10 part, Ramulus Mori 40-80 part, Ramulus Salicis Babylonicae 40-80 part.
Preferably, the Chinese medicine composition of above-mentioned external curing rheumatoid arthritis, wherein said compositions is prepared from by the Chinese crude drug of following weight proportion: Folium Citri tangerinae 36-42 part, Herba speranskiae tuberculatae 36-42 part, Rhizoma Acori Graminei 18-20 part, Radix Euphorbiae Pekinensis 6-8 part, Ramulus Mori 50-70 part, Ramulus Salicis Babylonicae 50-70 part.
In most preferred embodiment of the present invention, the Chinese medicine composition of described external curing rheumatoid arthritis is prepared from by the Chinese crude drug of following weight proportion: 38 parts of Folium Citri tangerinae, 38 parts of Herba speranskiae tuberculataes, 18 parts of Rhizoma Acori Graminei, 8 parts of the Radixs Euphorbiae Pekinensis, 60 parts of Ramulus Moris, 60 parts of Ramulus Salicis Babylonicaes.
The Chinese medicine composition of further preferably, above-mentioned external curing rheumatoid arthritis is powder.
By experimental study, find, the pharmaceutical composition being comprised of the Chinese crude drug of said ratio coordinates the evident in efficacy of western medicine rheumatoid arthritis.Therefore, second object of the present invention is to provide a kind of new medical use, i.e. the application of above-mentioned Chinese medicine composition in the medicine of preparation treatment rheumatoid arthritis.
According to Chinese medicine Historical Data Data About, the present invention's Chinese crude drug used has following pharmacologically active and function cures mainly:
Folium Citri tangerinae: soothing the liver, circulation of qi promoting, reduces phlegm, detumescence poison.Control hypochondriac pain, acute mastitis, lung abscess, cough, chest and diaphragm feeling of fullness, hernia.Select the leaf of the multiple Fructus Citri tangerinae classes such as the leaf of rutaceae orange Citrus reticulata Blanco or Zhu's Fructus Citri tangerinae.
Herba speranskiae tuberculatae: wind-damp dispelling, invigorate blood circulation, relaxing muscles and tendons, pain relieving.Dispelling the wind and dampness pathogens pain, sprain and contusion wound, innominate toxic swelling, eczema scrotum.Be selected from the young stem and leaf of leguminous plant Herba Viciae Amoenae.
Rhizoma Acori Graminei: removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.Derive from the rhizome of acorus gramineus araceae plant.
The Radix Euphorbiae Pekinensis: the effect with diuretic, detumescence; Cure mainly that edema distension, phlegm retention gather, carbuncle furunculosis.Select the root of Maguireothamnus speciosus Knoxia valerianoides or euphorbia plant Radix Euphorbiae Pekinensis.
Ramulus Mori: wind-damp dispelling, sharp joint, row aqueous vapor.Control anemofrigid-damp arthralgia, spasm of the limbs, beriberi edema, human body pruritus due to wind pathogen.Select the dry twig of moraceae plants Mulberry Morus alba L..
Ramulus Salicis Babylonicae: dispel the wind, diuresis, pain relieving, detumescence.Dispelling the wind and dampness pathogens arthralgia pain, gonorrhea, nebulousurine, urinary obstruction, infectious hepatitis, swelling due to wind, furuncle, erysipelas, dental caries, swelling of the gum.Select the dry branch of Salicaceous Plants Salix babylonica L..
Chinese medicine composition of the present invention has expelling wind and cold, eliminating dampness and dredging channels, promoting blood circulation to restore menstrual flow, the effect of promoting the circulation of QI to relieve pain, and short treating period, determined curative effect, have no side effect, simple and practical feature, patient is acceptant.
The specific embodiment
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
embodiment 1
Crude drug prescription:
380 grams of Folium Citri tangerinae, 380 grams of Herba speranskiae tuberculataes, 180 grams of Rhizoma Acori Graminei, 80 grams of the Radixs Euphorbiae Pekinensis, 600 grams of Ramulus Moris, 600 grams of Ramulus Salicis Babylonicaes.
Preparation method:
Get above-mentioned Chinese crude drug, clean roguing, dry, be ground into granule, pulverization, by every bag of 200 grams of packing.
embodiment 2
Crude drug prescription:
450 grams of Folium Citri tangerinae, 300 grams of Herba speranskiae tuberculataes, 180 grams of Rhizoma Acori Graminei, 100 grams of the Radixs Euphorbiae Pekinensis, 500 grams of Ramulus Moris, 660 grams of Ramulus Salicis Babylonicaes.
Preparation method:
Get above-mentioned Chinese crude drug, clean roguing, dry, be ground into granule, pulverization, by every bag of 200 grams of packing.
embodiment 3
Crude drug prescription:
500 grams of Folium Citri tangerinae, 500 grams of Herba speranskiae tuberculataes, 220 grams of Rhizoma Acori Graminei, 80 grams of the Radixs Euphorbiae Pekinensis, 650 grams of Ramulus Moris, 540 grams of Ramulus Salicis Babylonicaes.
Preparation method:
Get above-mentioned Chinese crude drug, clean roguing, dry, be ground into granule, pulverization, by every bag of 200 grams of packing.
embodiment 4
Crude drug prescription:
430 grams of Folium Citri tangerinae, 320 grams of Herba speranskiae tuberculataes, 200 grams of Rhizoma Acori Graminei, 60 grams of the Radixs Euphorbiae Pekinensis, 700 grams of Ramulus Moris, 800 grams of Ramulus Salicis Babylonicaes.
Preparation method:
Get above-mentioned Chinese crude drug, clean roguing, dry, be ground into granule, pulverization, by every bag of 200 grams of packing.
The effectiveness study of herbal fumigation to rheumatoid arthritis patients
By following diagnostic criteria, make a definite diagnosis rheumatoid arthritis: (1) deadlock in morning is 1h (>=6 weeks) at least; (2) 2 or 3 above arthroncuss (>=6 weeks); (3) wrist, the palm refer to, proximal interphalangeal joint swelling (>=6 weeks); (4) symmetry arthroncus (>=6 weeks); (5) rheumatoid subcutaneous nodule; (6) hands x-ray image changes (having osteoporosis and articular cavity narrow gaps at least); (7) rheumatoid factor positive (titre >l:32).In above 7, there are 4 diagnosable rheumatoid arthritiss of the positive.
Rheumatoid arthritis patients 56 examples of making a definite diagnosis by above-mentioned standard: 23~60 years old age, year mean age (46.2 ± 12.3); The course of disease 3~28 years, average course of disease (8.0 ± 5.9) year.All patients are divided into two groups at random: stifling group 28 examples, male 9 examples, female's 19 examples; Matched group 28 examples, male 10 examples, female's 18 examples; Two groups of Genders, age, courses of disease are learned processing by statistics, difference not statistically significant (P>0.O5).
Matched group is treated as follows: meloxicam tablet 7.5mg/d, in methotrexate 7.5mg/ week, does not add other drug, other treatment.Treat as follows for stifling group: on treatment of control group basis, coordinate Chinese medicine composition fumigation treatment of the present invention.Fumigating method: get 1 bag of the Chinese powder medicine of the embodiment of the present invention 1 preparation, soak 1h by proper amount of clear water, put in people's fumigate therapeutic apparatus (medicinal intelligent therapeutic instrument JS-809B) and boil, temperature operated by rotary motion is at 40-50 ℃.Patient's extremities joint or whole body are fumigated, for movable inconvenient joint, soak pathological changes joint after available towel adhesional wetting medicinal liquid, 1 time/d, 1 bag medicine is used 2d, stifling 30min at every turn, 20d is 1 course for the treatment of, evaluates curative effect after treating 2 courses for the treatment of.
Efficacy assessment standard is divided into three grades: effective: symptomatology is eliminated or cardinal symptom is eliminated, and function of joint is recovered substantially, can participate in normal operation and work, laboratory checking index normal; Effective: cardinal symptom is eliminated substantially, main function of joint is substantially recovered or is obviously progressive, and can't take care of oneself to transfer to can take care of oneself, or loses the job and work capacity transfers work to and ability to work is recovered to some extent, and laboratory checking index makes moderate progress; Invalid: relatively front with treatment, each side is all without progressive.
Two groups of Clinical efficacy comparisons are in Table 1.By table 1, can find out, after treatment, the stifling group of total effective rate is 96.4%, and matched group is 57.1%, and the obvious effective rate of stifling group treatment rheumatoid arthritis is obviously better than matched group.In addition, compare with matched group, stifling group can significantly be improved the symptom and signs such as arthralgia, dysfunction.
Table 1 liang group patient curative effect comparison

Claims (5)

1. a Chinese medicine composition for external curing rheumatoid arthritis, is characterized in that: described compositions is prepared from by the Chinese crude drug of following weight proportion: Folium Citri tangerinae 30-50 part, Herba speranskiae tuberculatae 30-50 part, Rhizoma Acori Graminei 15-22 part, Radix Euphorbiae Pekinensis 6-10 part, Ramulus Mori 40-80 part, Ramulus Salicis Babylonicae 40-80 part.
2. the Chinese medicine composition of external curing rheumatoid arthritis according to claim 1, is characterized in that: described compositions is prepared from by the Chinese crude drug of following weight proportion: Folium Citri tangerinae 36-42 part, Herba speranskiae tuberculatae 36-42 part, Rhizoma Acori Graminei 18-20 part, Radix Euphorbiae Pekinensis 6-8 part, Ramulus Mori 50-70 part, Ramulus Salicis Babylonicae 50-70 part.
3. the Chinese medicine composition of external curing rheumatoid arthritis according to claim 2, is characterized in that: described compositions is prepared from by the Chinese crude drug of following weight proportion: 38 parts of Folium Citri tangerinae, 38 parts of Herba speranskiae tuberculataes, 18 parts of Rhizoma Acori Graminei, 8 parts of the Radixs Euphorbiae Pekinensis, 60 parts of Ramulus Moris, 60 parts of Ramulus Salicis Babylonicaes.
4. according to the Chinese medicine composition of the external curing rheumatoid arthritis described in claim 1 or 2 or 3, it is characterized in that: described compositions is powder.
5. the application of the compositions described in claim 1 or 2 or 3 in the medicine of preparation treatment rheumatoid arthritis.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109350658A (en) * 2018-12-14 2019-02-19 北京蜂珍科技开发有限公司 A kind of bee venom Chinese medicine scraping oil for rheumatic arthritis
CN109364166A (en) * 2018-12-14 2019-02-22 北京蜂珍科技开发有限公司 A kind of water-soluble scraping agent containing bee venom

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101164604A (en) * 2007-06-11 2008-04-23 徐发成 Traditional Chinese medicine for treating arthrosis and preparing method thereof
CN101862421A (en) * 2010-06-09 2010-10-20 杨青 Chinese medicinal ointment composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101164604A (en) * 2007-06-11 2008-04-23 徐发成 Traditional Chinese medicine for treating arthrosis and preparing method thereof
CN101862421A (en) * 2010-06-09 2010-10-20 杨青 Chinese medicinal ointment composition

Non-Patent Citations (1)

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Title
吕军影: "中医外治类风湿性关节炎近况", 《黑龙江中医药》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109350658A (en) * 2018-12-14 2019-02-19 北京蜂珍科技开发有限公司 A kind of bee venom Chinese medicine scraping oil for rheumatic arthritis
CN109364166A (en) * 2018-12-14 2019-02-22 北京蜂珍科技开发有限公司 A kind of water-soluble scraping agent containing bee venom

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Inventor after: Liu Shupeng

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Address after: 226400 Jiangsu County of Rudong province juegang Jianghai Road No. 10 building three unit 302 room

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