CN101954043A - Medicament for treating hyperosteogeny and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament for treating hyperosteogeny. The preparation method comprises the following steps of: baking and milling black-striped snake, Chinese honeylocust spine, white mustard seed, garden balsam stem, divaricate saposhnikovia root, frank incense, myrrh, incised notopterygium rhizome, heracleum, manchurian wildginger, safflower, trogopterus dung, clematis root, common monkshood mother root, kusnezoff monkshood root, sappan wood, common burreed rhizome, zedoary, twotooth achyranthes root, clove, ground beeltle, stiff silkworm, kadsura pepper stem, giant typhonium rhizome, cassia twig, cowherb seed, common clubmoss herb, and pinellia ternata, adding vaseline, vinegar and liquor, and heating and stirring to prepare a plaster. The medicament has the effects of activating meridians and collaterals, strengthening tendons and bones, dispelling wind and damp and circulating Qi and blood, is used for treating the hyperosteogeny, has the advantages of exact curative effect, rapidness, convenience, low cost, safe administration, and the effective rate of 95.0 percent through clinical observation.

Description

A kind of medicine for the treatment of hyperosteogeny and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of hyperosteogeny, particularly relating to a kind of is the Chinese medicine of the treatment hyperosteogeny of feedstock production with Chinese medicine, and the preparation method of this medicine.

Background technology

Hyperosteogeny medically is being called osteoarthritis or osteoarthritis, mainly is because due to the bone wearing and tearing that the mechanical stress distribution is unbalance or load excessively causes.Every day is all being born the mechanical force that comings and goings causes in people's joint, and after people in middle age, muscle function is faded, and causes joint injury easily, and cartilage destruction causes osteoarthritis.Hyperosteogeny is middle old man's a common frdquently encountered disease, is mainly in the mobility maximum, the positions such as maximum cervical vertebras, lumbar vertebra, sacral, knee joint, heel of bearing a heavy burden.With advancing age, people's articular cartilage elasticity can fall sharply, and the chondrigen fiber appears, and very easily weares and teares when the middle part, joint is movable, and its periphery cartilage surface just metabolic increases the plumpness of dying, the ossified at last bony spur that forms.

The method of treatment hyperosteogeny mainly contains operative treatment, physical therapy, Western medicine and treatment by Chinese herbs etc. at present.But, adopt operation method expense height, and increase patient's misery; Though adopt physical therapy method can alleviate patient's misery, just, can not effect a radical cure to the alleviation of symptom; Adopt western medicine, its drug price is more expensive, and may cause side effect; At present the treatment by Chinese herbs method that adopts takes effect slowly, and the state of an illness recurs easily, and Chinese prescription and preparation method thereof complexity, and the drug cost height is difficult to be accepted by the patient.

Summary of the invention

The purpose of this invention is to provide a kind of medicine that is used for the treatment of hyperosteogeny, this medicine dredge the meridian passage, bone and muscle strengthening, wind-damp dispelling, ventilator can play treating both the principal and secondary aspects of a disease to the treatment of hyperosteogeny, and drug effect is rapid, the purpose that therapeutic effect is good.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Zaocys 4～6 Spina Gleditsiae 4～6

Semen Sinapis Albae 0.5～2 Herba speranskiae tuberculatae 6～8

Radix Saposhnikoviae 4～6 Olibanums 4～6

Myrrha 4～6 Rhizoma Et Radix Notopterygiis 4～6

Radix Angelicae Pubescentis 4～6 Herba Asaris 2～3

Flos Carthami 3～5 Oletum Trogopteroris 5～7

Radix Clematidis 5～7 Radix Aconitis 2～4

Radix Aconiti Kusnezoffii 2～4 Lignum Sappans 2～4

Rhizoma sparganic 3～4 Rhizoma Curcumae 3～4

Radix Achyranthis Bidentatae 4～6 Flos Caryophyllis 1～3

Eupolyphaga Seu Steleophaga 2～4 Bombyx Batryticatus 3～5

Caulis Piperis Kadsurae 6～8 Rhizoma Typhoniis 2～4

Ramulus Cinnamomi 3～5 Semen Vaccariae 3～5

Herba Lycopodii 5～7 GUANYUZI 0.5～1

Said medicine can be made any external used medicine dosage form on the pharmaceutics, as unguentum, tincture, powder etc., the preferred dosage form of the present invention is a unguentum.

The concrete preparation method of medicine of the present invention being made unguentum is:

Said medicine mixed wear into 100 purpose fine powders, add the vaseline of 8～10 times of drug weight, the wine of 6～8 times vinegar and 0.4～0.6 times, heated and stirred becomes the cream sample standby.

During use, it is an amount of to get the plaster of making, and, pastes 24 hours in the affected part with immobilization with adhesive tape at every turn, and the next day pastes 1 time.

Bone matrix hyperplasia belongs to the traditional Chinese medical science " arthromyodynia " category, and the cause of disease is the natural endowment deficiency, and the day after tomorrow, impairment caused by overstrain of a specified duration and Liver and kidney caused deficiency of liver-blood, and the muscle arteries and veins loses supports; Deficiency of kidney-essence, bone is become homeless foster; Muscle loses and makes moist, and venation block is inaccessible obstructed.The Therapeutic Principle is dredge the meridian passage, powerful bone strengthening, wind-damp dispelling, ventilator.Zaocys wind-damp dispelling, the meridian dredging; Spina Gleditsiae draw out pus by applying a plaster to the affected part evacuation of pus, promoting blood circulation and detumescence; Semen Sinapis Albae warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving; Herba speranskiae tuberculatae expelling wind and removing dampness, detoxifcation pain relieving; Radix Saposhnikoviae expelling pathogenic wind from the body surface, removing dampness to relieve pain relieving convulsion; The pain relieving of Olibanum regulating qi and activating blood; Myrrha loose blood blood stasis removing, subduing swelling and relieving pain; The Rhizoma Et Radix Notopterygii cold expelling dispels the wind, removing damp and stopping pain; The detoxifcation of Radix Angelicae Pubescentis dispelling wind, promoting blood circulation to disperse blood clots and relieves pain; Herba Asari expelling wind and cold, Hang Shui have one's ideas straightened out; Flos Carthami invigorate blood circulation latus rectum, eliminating stasis to stop pain; The hemostasis of Oletum Trogopterori promoting blood circulation to remove blood stasis; Radix Clematidis expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the hypochondriac lump of loosing; Radix Aconiti expelling wind and removing dampness, antalgic; Radix Aconiti Kusnezoffii expelling wind and removing dampness, antalgic; Lignum Sappan promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain; Rhizoma sparganic promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain; Rhizoma Curcumae removing blood stasis, promoting the circulation of QI to relieve pain; Radix Achyranthis Bidentatae eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome; Flos Caryophylli warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI; Eupolyphaga Seu Steleophaga removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones; Bombyx Batryticatus expelling wind for relieving convulsion, dissipating phlegm and resolving masses; Caulis Piperis Kadsurae wind-damp dispelling, the meridian dredging, stopping numbness pain; Rhizoma Typhonii dispel the wind expectorant, the arresting convulsion jerk, the detoxicating and resolving stagnation of pathogens pain relieving; Ramulus Cinnamomi diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain; Semen Vaccariae promoting blood circulation to restore menstrual flow, stimulating milk secretion eliminating carbuncle, inducing diuresis for treating stranguria syndrome; Herba Lycopodii expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral; GUANYUZI strengthening the spleen stomach, the scrofula that disappears eliminating stagnation.All medicines share, and the effect of medicine and wine mutually combines, and the effect of its inducing menstruation to relieve menalgia, wind-damp dispelling, strengthening bone and muscle is more remarkable.

Medicine blood circulation promoting and blood stasis dispelling of the present invention, pain relieving cold expelling can reach the deep wind of searching, promoting the flow of QI in the collateral by warming the meridian, the effect of expelling wind and removing dampness is mainly used in rheumatic arthritis, the treatment of bone sexually transmitted disease (STD)s such as cold-damp arthralgia, hyperosteogeny, have curative effect really, rapidly, conveniently, the medicine valency is cheap, takes safe characteristics.

For further investigating the clinical efficacy and the safety of medicine of the present invention, select 200 routine hyperosteogeny patients that the curative effect of medicine of the present invention is carried out clinical observation.

Physical data

200 routine cases are divided into two groups at random, every group 100 example.Male 56 examples in the matched group, women's 44 examples; 35～72 years old age, 53.2 years old mean age; Course of disease 3d～5 year; Lumbar X line sheet prompting physiological curve shoals or 62 examples that disappear, and the bone bridge forms 18 examples, and ligament thickens or calcification 20 examples around the vertebral body.Male 58 examples are organized in treatment, women 42 examples; 33～68 years old age, average 50.6 years old; Course of disease 7d～4.6 year; Lumbar X line sheet prompting physiological curve shoals or 60 examples that disappear, and the bone bridge forms 18 examples, and ligament thickens or calcification 22 examples around the vertebral body.Two groups of cases at aspects such as sex, age, the courses of disease by statistics credit analyse not statistically significant (P＞0.05), have comparability.

Diagnostic criteria

Make a definite diagnosis i.e. 1. low-back pain, tired postemphasis according to diagnosis basis and typing in " lumbar vertebra hyperosteogeny diagnosis and treatment complete works ".2. it is stiff to play waist morning, and the pain sense of discomfort is more obvious.3. waist has tenderness.4. waist limitation of activity.5. lumbar X sheet or CT show that lumbar vertebra has hyperosteogeny to sexually revise.

Therapeutic Method

Matched group adopts Novolten capsule (Hainan Pulin Pharmaceutical Co., Ltd's production) 100mg, and every day 1 time, oral meal serve on for 2 weeks; Logical (Tianhe Pharmacy Industry Co., Ltd., Gulin's production) external application treatment of external sky and bone.The treatment group adopts medicine of the present invention to treat.2 weeks were 1 course of treatment, used 2 courses of treatment altogether.

Criterion of therapeutical effect

Formulate with reference to State Administration of Traditional Chinese Medicine's " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ".Recovery from illness: lumbago and skelalgia transference cure, activity are followed up a case by regular visits to not recurrence in 1 year freely.Take a turn for the better: the lumbago and skelalgia symptom obviously alleviates, but still has sense of discomfort, follows up a case by regular visits to and does not increase the weight of in 1 year.Effectively: the lumbago and skelalgia symptom slightly alleviates.Invalid: lumbago and skelalgia symptom and the preceding contrast of treatment no change.

Two groups of case treatment back curative effect comparative results see Table 1.

Table 1 liang group case treatment back curative effect relatively

The specific embodiment

Embodiment 1

Get Zaocys 4g selected, that clear water is cleaned, Spina Gleditsiae 4g, Semen Sinapis Albae 0.5g, Herba speranskiae tuberculatae 6g, Radix Saposhnikoviae 4g, Olibanum 4g, Myrrha 4g, Rhizoma Et Radix Notopterygii 4g, Radix Angelicae Pubescentis 4g, Herba Asari 2g, Flos Carthami 3g, Oletum Trogopterori 5g, Radix Clematidis 5g, Radix Aconiti 2g, Radix Aconiti Kusnezoffii 2g, Lignum Sappan 2g, rhizoma sparganic 3g, Rhizoma Curcumae 3g, Radix Achyranthis Bidentatae 4g, Flos Caryophylli 1g, Eupolyphaga Seu Steleophaga 2g, Bombyx Batryticatus 3g, Caulis Piperis Kadsurae 6g, Rhizoma Typhonii 2g, Ramulus Cinnamomi 3g, Semen Vaccariae 3g, Herba Lycopodii 5g, GUANYUZI 0.5g dries the back mixing and wears into 100 purpose fine powders.

Get vaseline 800g, mature vinegar 750mL, wine 50mL, heating adds mature vinegar after vaseline becomes liquid state successively, wine and the good medicated powder of mill, it is standby fully to stir into the cream sample.

During use, it is an amount of to get the plaster of making, and, pastes 24 hours in the affected part with immobilization with adhesive tape at every turn, and the next day pastes 1 time.

Embodiment 2

Get Zaocys 15g selected, that clear water is cleaned, Spina Gleditsiae 25g, Semen Sinapis Albae 4g, Herba speranskiae tuberculatae 25g, Radix Saposhnikoviae 25g, Olibanum 25g, Myrrha 15g, Rhizoma Et Radix Notopterygii 25g, Radix Angelicae Pubescentis 25g, Herba Asari 5g, Flos Carthami 20g, Oletum Trogopterori 20g, Radix Clematidis 20g, Radix Aconiti 10g, Radix Aconiti Kusnezoffii 5g, Lignum Sappan 10g, rhizoma sparganic 15g, Rhizoma Curcumae 20g, Radix Achyranthis Bidentatae 25g, Flos Caryophylli 10g, Eupolyphaga Seu Steleophaga 5g, Bombyx Batryticatus 20g, Caulis Piperis Kadsurae 35g, Rhizoma Typhonii 5g, Ramulus Cinnamomi 10g, Semen Vaccariae 10g, Herba Lycopodii 20g, GUANYUZI 3g dries the back mixing and wears into 100 purpose fine powders.

Get vaseline 4Kg, mature vinegar 3.6L, wine 250mL, heating adds mature vinegar after vaseline becomes liquid state successively, wine and the good medicated powder of mill, it is standby fully to stir into the cream sample.

Claims (3)

1. medicine for the treatment of hyperosteogeny is that feedstock production obtains by following parts by weight of traditional Chinese medicines:

Zaocys 4～6 Spina Gleditsiae 4～6

Semen Sinapis Albae 0.5～2 Herba speranskiae tuberculatae 6～8

Radix Saposhnikoviae 4～6 Olibanums 4～6

Myrrha 4～6 Rhizoma Et Radix Notopterygiis 4～6

Radix Angelicae Pubescentis 4～6 Herba Asaris 2～3

Flos Carthami 3～5 Oletum Trogopteroris 5～7

Radix Clematidis 5～7 Radix Aconitis 2～4

Radix Aconiti Kusnezoffii 2～4 Lignum Sappans 2～4

Rhizoma sparganic 3～4 Rhizoma Curcumae 3～4

Radix Achyranthis Bidentatae 4～6 Flos Caryophyllis 1～3

Eupolyphaga Seu Steleophaga 2～4 Bombyx Batryticatus 3～5

Caulis Piperis Kadsurae 6～8 Rhizoma Typhoniis 2～4

Ramulus Cinnamomi 3～5 does not stay row 3～5

Herba Lycopodii 5～7 GUANYUZI 0.5～1.

2. the medicine of treatment hyperosteogeny according to claim 1 is characterized in that described medicine is made unguentum.

3. the preparation method of the medicine of the described treatment hyperosteogeny of claim 2 is said medicine to be mixed wear into 100 purpose fine powders, adds the vaseline of 8～10 times of drug weight, the wine of 6～8 times vinegar and 0.4～0.6 times, and heated and stirred becomes the cream sample standby.