CN105560537A - Medicine composition for treating osteoartritis and preparation method thereof - Google Patents

Medicine composition for treating osteoartritis and preparation method thereof Download PDF

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Publication number
CN105560537A
CN105560537A CN201610057826.0A CN201610057826A CN105560537A CN 105560537 A CN105560537 A CN 105560537A CN 201610057826 A CN201610057826 A CN 201610057826A CN 105560537 A CN105560537 A CN 105560537A
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radix
powder
preparation
substrate
group medicine
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苏日特勒图
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Na Ren Figure Is Refined
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • A61K36/12Filicopsida or Pteridopsida
    • A61K36/126Drynaria
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264Aristolochia (Dutchman's pipe)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/59Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/67Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/732Chaenomeles, e.g. flowering quince
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/77Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms

Abstract

The invention discloses a medicine composition for treating osteoartritis and a preparation method thereof. The medicine composition is prepared from raw materials containing effective constituents, including lignum sappan, caulis sinomenii, angelica sinensis, common flowering quince fruits, rhizoma cibotii, rhizoma drynariae, radix angelicae pubescentis, medicinal cyathula roots, cassia twigs, kudzu vine roots, white mustard seeds, raw radix aconiti, raw radix aconiti kusnezoffii, nettle roots, tuberculate speranskia herbs, Chinese ilex leaves, herba lycopodii, wooly datchmanspipe herbs, flos carthami, frankincense, myrrh, fructus piperis and borneol. The medicine composition for treating osteoartritis is reasonable in compounding, all medicinal materials of the medicine composition achieve the synergistic effects of diminishing inflammation, relieving pain, activating yellow water, dispersing blood stasis and stagnation, clearing and activating the channels and collaterals, drawing out poison, removing dampness, expelling wind, removing cold and the like, clinical test results show that the medicine composition is remarkable in treatment effect and capable of effectively treating osteoartritis, and the effective rate is as high as 90% and above.

Description

A kind of pharmaceutical composition for the treatment of osseous arthritis and preparation method thereof
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of osseous arthritis and preparation method thereof.
Background technology
Osseous arthritis sickness rate in older population is very high.Osseous arthritis is a kind of degeneration, owing to increasing articular cartilage degeneration damage that the factors such as age, obesity, strain, wound, joint birth defect, joint deformity causes, joint margins and subchondral bone reactive hyperplasia, also known as joint disease, degenerative osteoarthritis, senile arthritis, hypertrophiarthritis etc.Clinical manifestation is the arthralgia of slowly development, stiff, arthroncus, limitation of activity and joint deformity etc.Along with the increase at people's age, this disease can cause the result of disability and motor capacity, even can't take care of oneself, and causes great body and mind to damage to patient.
Osteoarthritis, with the be full of cracks of articular cartilage generation diffusivity, fibrosis and depigmentation and the one group of clinical signs group being changed to feature because osseous tissue is Hypertrophic, is be more common in middle aged later chronic progressive external joint diseases.Be one of large senile disease of China four, its high prevalence, high disability rate and high medical expense, had a strong impact on the development of quality of life of patients and social productive forces.Along with the aging of China's population, the prevalence of osteoarthritis is up to 8.3% of total number of persons.There is no the Therapeutic Method of satisfactory effect at present.
Hyperosteogeny, prolapse of lumbar intervertebral disc, cervical spondylosis, scapulohumeral periarthritis, spinal canal stenosis, lumbar muscle strain, bony spur belong to aseptic inflammation, and general antibiotic medicine is inoperative.Tablet for alleviating pain is cured the symptoms, not the disease, to gastrointestinal injury greatly.Operation wound is large, and risk is high, and convalescent period is long, and thus somewhat expensive is extremely restricted, and makes the ability of patient's substantial loss work and the strenuous exercise performed the operation, and the recurrence phase of many successful surgery patients is also at about 3-4.So the general hospital be on a grand scale also is at a loss what to do to this disease.Doctor trained in Western medicine circle is thought more, and current medical science also ability does not make this type of course of disease reverse, and patient can only use analgesic, pain killer injection relief of symptoms.
Summary of the invention
The technical problem to be solved in the present invention is the medicine that there is no effectively treatment osseous arthritis in prior art.
In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition for the treatment of osseous arthritis, being made up of the raw material comprising following active ingredient:
Lignum Sappan, wood of shiny-leaved yellowhorn, Caulis Sinomenii, Radix Angelicae Sinensis, Fructus Chaenomelis, Rhizoma Cibotii, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Cyathulae, Ramulus Cinnamomi, Radix Puerariae, Semen Sinapis Albae, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Urticae Cannabinae, Herba speranskiae tuberculatae, Folium Ilicis Purpureae; Herba Lycopodii, Herba Aristolochiae Mollissimae, Flos Carthami, Olibanum, Myrrha, Fructus Piperis, Borneolum Syntheticum.
Preferably, described raw material also comprises adjuvant: azone and infrared ceramic powder.
Preferably, the pharmaceutical composition of above-mentioned treatment osseous arthritis is made up of the raw material of the active ingredient comprising following parts by weight:
Lignum Sappan 20-30, wood of shiny-leaved yellowhorn 15-25, Caulis Sinomenii 6-12, Radix Angelicae Sinensis 6-12, Fructus Chaenomelis 6-9, Rhizoma Cibotii 6-12, Rhizoma Drynariae 3-9, Radix Angelicae Pubescentis 3-10, Radix Cyathulae 5-10, Ramulus Cinnamomi 3-10, Radix Puerariae 10-15, Semen Sinapis Albae 3-9, Radix Aconiti 5-10, Radix Aconiti Kusnezoffii 5-10, Radix Urticae Cannabinae 10-15, Herba speranskiae tuberculatae 9-15, Folium Ilicis Purpureae 10-15; Herba Lycopodii 3-12, Herba Aristolochiae Mollissimae 10-20, Flos Carthami 3-10, Olibanum 3-5, Myrrha 3-5, Fructus Piperis 3-5, Borneolum Syntheticum 1.5-3.
Preferably, described raw material also comprises the adjuvant of following parts by weight: azone 2 ~ 4, infrared ceramic powder 5 ~ 7.
Present invention also offers the preparation method of the pharmaceutical composition of above-mentioned treatment osseous arthritis, comprise the steps:
(1) preparation of active ingredient: get A group medicine: Lignum Sappan, wood of shiny-leaved yellowhorn, Caulis Sinomenii, Radix Angelicae Sinensis, Fructus Chaenomelis, Rhizoma Cibotii, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Cyathulae, Ramulus Cinnamomi, Radix Puerariae, Semen Sinapis Albae, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Urticae Cannabinae, Herba speranskiae tuberculatae and Folium Ilicis Purpureae, pulverize, soak, then boil with fire, filter, filtrate is condensed into extractum, dries, pulverizes as powder; Get B group medicine: Herba Lycopodii, Herba Aristolochiae Mollissimae, Flos Carthami, Olibanum, Myrrha, Fructus Piperis and Borneolum Syntheticum, pulverize as powder;
(2) preparation of substrate: get Colophonium and Oleum Sesami is brewed into oily, obtains substrate;
(3) mixing of spice: substrate heating step (2) obtained, mixes the powder obtained by A group medicine in step (1) and the powder that obtained by B group medicine in the substrate after heating.
Preferably, present invention also offers the preparation method of the pharmaceutical composition of above-mentioned treatment osseous arthritis, comprise the steps:
(1) preparation of active ingredient: get A group medicine: Lignum Sappan, wood of shiny-leaved yellowhorn, Caulis Sinomenii, Radix Angelicae Sinensis, Fructus Chaenomelis, Rhizoma Cibotii, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Cyathulae, Ramulus Cinnamomi, Radix Puerariae, Semen Sinapis Albae, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Urticae Cannabinae, Herba speranskiae tuberculatae and Folium Ilicis Purpureae, pulverize, soak, then boil with fire, filter, filtrate is condensed into extractum, dries, pulverizes as powder; Get B group medicine: Herba Lycopodii, Herba Aristolochiae Mollissimae, Flos Carthami, Olibanum, Myrrha, Fructus Piperis and Borneolum Syntheticum, pulverize as powder;
(2) preparation of substrate: get Colophonium and Oleum Sesami is brewed into oily, obtains substrate;
(3) mixing of spice: substrate heating step (2) obtained, by the powder obtained by A group medicine in step (1), the powder obtained by B group medicine and azone and infrared ceramic powder, mixes in the substrate after heating.
As optimal technical scheme, soak after the middle A group medicated powder of step (1) is broken, then boil three times with fire: after boiling 2 ~ 3 hours with fire, filter, after filtering residue boils 1.5 ~ 2.5 hours, filter, filtering residue boils 1 ~ 2 hour again, filters, merging filtrate, is condensed into extractum, dries, pulverizes as powder.
As optimal technical scheme, in step (2), the mass ratio of Colophonium and Oleum Sesami is 1:1 ~ 5:1.
As optimal technical scheme, after in step (2), Colophonium and Oleum Sesami are brewed into oily, cooling, is poured into water, and stirs, soaks more than 10 hours, with releasing fire-toxin, prevent allergy.
As optimal technical scheme, substrate is heated to 60 ~ 70 DEG C in (3) by step; The powder that A group medicine obtains and the gross weight of powder obtained by B group medicine and the weight ratio of substrate are: 5 ~ 8:10.
The present invention can reach following beneficial effect:
1, the assembly of the pharmaceutical composition for the treatment of osseous arthritis provided by the invention is reasonable, its drug synergism has antiinflammatory, pain relieving, yellow fluid blood stasis dispelling of living is stagnant, dredge the meridian passage, to draw out pus by applying a plaster to the affected part damp eliminating, the effects such as expelling wind and cold, clinical test results shows, and it is evident in efficacy, effectively can treat osseous arthritis, effective percentage is up to more than 90%.
The advantages such as 2, the pharmaceutical composition for the treatment of osseous arthritis of the present invention is colophony type externally applied ointment, and drug loading is large, and without high-temperature process, the effective content of medicine is high, plaster length service time.Existing external tradition plaster is mostly with Chinese medicine preparation effective content minimizing 20%--30% in medicine after " fried endure withered " high-temperature process (280-320 DEG C), and even someone reports minimizing 40%.And the present invention is in conjunction with Mongolian medicine's theory and practice, excavate the marrow in pure natural illiteracy herbal medicinal product, utilize convenient-to-running preparation process, for the osteoarthrosis illness-hyperosteogeny caused a significant threat health, develop safety, effectively, mongolian medicine external use plaster easily.
3, the pharmaceutical composition for the treatment of osseous arthritis of the present invention, preparation is simple, with short production cycle, environmentally safe during making, to human body skin without irritated nonhazardous.What preparation technology taked is machining at low temperature, and general temperature is the highest at 100 degrees centigrade, and biological activity is not easily destroyed.Utilize distinct methods to extract effective ingredient, can remove impurity to greatest extent, ensure that the purity of plaster is high, quality is good.Only need utilize human body heating power during use, namely plaster can be adsorbed on pasted position, and not easily slides.Life-time service is little to skin irritation, can use continuously.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, can better understand the present invention and can be implemented, but illustrated embodiment is not as a limitation of the invention to make those skilled in the art.
The invention discloses a kind of pharmaceutical composition for the treatment of osseous arthritis, it is made up of the raw material containing, for example lower active ingredient:
Lignum Sappan, wood of shiny-leaved yellowhorn, Caulis Sinomenii, Radix Angelicae Sinensis, Fructus Chaenomelis, Rhizoma Cibotii, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Cyathulae, Ramulus Cinnamomi, Radix Puerariae, Semen Sinapis Albae, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Urticae Cannabinae, Herba speranskiae tuberculatae, Folium Ilicis Purpureae; Herba Lycopodii, Herba Aristolochiae Mollissimae, Flos Carthami, Olibanum, Myrrha, Fructus Piperis, Borneolum Syntheticum.
It is prepared by the following method:
(1) preparation of active ingredient: get A group medicine: Lignum Sappan, wood of shiny-leaved yellowhorn, Caulis Sinomenii, Radix Angelicae Sinensis, Fructus Chaenomelis, Rhizoma Cibotii, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Cyathulae, Ramulus Cinnamomi, Radix Puerariae, Semen Sinapis Albae, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Urticae Cannabinae, Herba speranskiae tuberculatae and Folium Ilicis Purpureae, pulverize as soaking after powder, then boil with fire, filter, filtrate is condensed into extractum, dry, pulverize as powder; Get B group medicine: Herba Lycopodii, Herba Aristolochiae Mollissimae, Flos Carthami, Olibanum, Myrrha, Fructus Piperis and Borneolum Syntheticum, pulverize as powder;
(2) preparation of substrate: get Colophonium and Oleum Sesami is brewed into oily, obtain substrate, (preferably, the mass ratio of Colophonium and Oleum Sesami is 1:1 ~ 5:1, rosin content is higher than Oleum Sesami, and substrate obtained within the scope of this is easier to merge with active ingredient, and more docile when being covered on skin, penetration enhancement);
(3) mixing of spice: the substrate that step (2) obtains is heated to 60 ~ 70 DEG C, mixes the powder obtained by A group medicine in step (1) and the powder that obtained by B group medicine in the substrate after heating.
Using method of the present invention is be spread out in by the pharmaceutical composition of obtained treatment osseous arthritis on desensitization cloth, is then overlying on patient's appearance acupuncture point or affected part.The present invention utilizes medicine directly to impose on patient's appearance acupuncture point or affected part, and the path by meridians plays the network that stimulates the menstrual flow away of medicine, have one's ideas straightened out deep, relaxing muscles and tendons to promote blood circulation, wind dispelling cold expelling, and the function of reducing swelling and alleviating pain, dispels virulence factor, thus reaches the object of curing disease.
What the pharmaceutical composition for the treatment of osseous arthritis of the present invention utilized is the plaster therapy adopting Mongolian medicine's crude drug principle, its use group medicine mutually coordinate into usefulness, the prescription of composition multidigit medicine, to play the good result of medicine, be affixed on flesh table, make the medicine taking abnormal smells from the patient dense in medicine, add with guiding drug neck group medicine, the stagnant through focus of row of having one's ideas straightened out.Therefore can penetrate skin and produce antiinflammatory, pain relieving, yellow fluid blood stasis dispelling of living is stagnant, dredge the meridian passage, damp eliminating of drawing out pus by applying a plaster to the affected part, the effect of expelling wind and cold.By excite nerve tip and the reflection of plaster, blood vessel dilating, promotes local blood circulation, improves surrounding tissue nutrition, reaches detumescence antiinflammatory and analgesic object.Simultaneously medicine to be gone directly subcutaneous tissue by Cutaneous permeation in affected part, produces the relative potence of drug level, thus play stronger efficacy of a drug effect in local.In addition, because of the medicine that some zest in plaster is stronger, by neural reflex, human body function enhancing antibody can be regulated to be formed, improve body immunity, after medicine scatters skin mucosa, enter body circulation through Haemolymphoid, systemic drug effect can be reached.
The principle that the pharmaceutical composition that osseous arthritis is treated in treatment of the present invention utilizes colophony type plaster to cure the disease: the object reaching treatment by oral administration of medicines by external treatment, external treatment is the same with internal treatment theoretical for instructing with Mongolia Medicine, externally applied plaster therapy is used to be acted on the result of body by different approaches, namely wear, go, support mechanism to reach reinforcing body resistance, the object of eliminating pathogens.The plaster posted on skin absorbs by sweat gland, cortex passage, horny layer conversion and epidermis deep layer conversion.The humidity of cuticular water content and external environment is closely related, plaster outer plaster, and horny layer is after the increase of hydration, be expandable into the state of porous, be easy to medicine and penetrate, drug transdermal speed is increased, Pi Wen can also be made to increase simultaneously, play the effect accelerating skin penetration rate.Some surfactants contained in plaster, can promote the Absorption of Passive diffusion, increase epidermis lipid membrane to the transmitance of medicine." have one's ideas straightened out and have perfume (or spice) ", " having cracked pungent ", aromatics medicine is used for local, and corticosteroid transdermal capability can be made to improve." stimulate the menstrual flow away network ", channel system network whole body links up the exterior and the interior, up and down, internal organs.This is the local action that disease is then controlled of seeing of external treatment, therefore plaster external treatment, there is good local efficacy.The features such as plaster therapy is entered in body by Cutaneous permeation at ingredient, thus play a kind of administering mode of therapeutical effect, and effect is directly, easy to use, abundant to drug absorption, with strong points.Patch therapy medicine Vapor recovery unit, lastingly, and can make blood drug level substantially remain on relatively stable level, thus avoid oral, occur administration concentration peak in injection, is exactly to reduce medicine to a certain extent to the toxic and side effects of human body.
Plaster therapy belongs to the one of external treatment, and it reaches a kind of therapy of disease therapy object by body surface osmotic drug to sufferer place.Existing external tradition plaster is mostly with the effective content minimizing 20%--30% of Chinese medicine preparation after " fried endure withered " high-temperature process in medicine, and even someone reports minimizing 40%.Plaster of the present invention have anticorrosion, anti-dry, keep drug effect, be convenient to paste and absorb with, chafe telangiectasis and the effect such as moistening.Plaster prescriptions is returned through principle according to general medical herbs, use medicine coordinate mutually into usefulness, the compound recipe of composition multi-flavor medicine, to play the good effect of medicine.Treatment hyperosteogeny position that plaster pastes and acupuncture point, through cave according to body surface, by means of meridians passage directly to affect diseased region, stimulate affected part teleneuron, by reflection, blood vessel dilating, promote local blood circulation, produce nerve-specific, regulating YIN and YANG balances, reach sedation-analgesia, the effects such as anti-inflammation detumescence.
With several specific embodiment, the present invention will be described below:
Embodiment 1
The pharmaceutical composition of the treatment osseous arthritis of the present embodiment is made up of the raw material of following parts by weight:
A group medicine:
Lignum Sappan 25g, wood of shiny-leaved yellowhorn 20g, Caulis Sinomenii 8g, Radix Angelicae Sinensis 10g, Fructus Chaenomelis 7g, Rhizoma Cibotii 9g, Rhizoma Drynariae 6g, Radix Angelicae Pubescentis 7g, Radix Cyathulae 8g, Ramulus Cinnamomi 7g, Radix Puerariae 12g, Semen Sinapis Albae 5g, Radix Aconiti 7g, Radix Aconiti Kusnezoffii 6g, Radix Urticae Cannabinae 12g, Herba speranskiae tuberculatae 12g, Folium Ilicis Purpureae 13g;
B group medicine:
Herba Lycopodii 6g, Herba Aristolochiae Mollissimae 15g, Flos Carthami 8g, Olibanum 4g, Myrrha 5g, Fructus Piperis 4g, Borneolum Syntheticum 2g.
Adjuvant: azone 3g, infrared ceramic powder 6g.
Its preparation method is as follows:
(1) preparation of active ingredient: get A group medicine: Lignum Sappan, wood of shiny-leaved yellowhorn, Caulis Sinomenii, Radix Angelicae Sinensis, Fructus Chaenomelis, Rhizoma Cibotii, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Cyathulae, Ramulus Cinnamomi, Radix Puerariae, Semen Sinapis Albae, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Urticae Cannabinae, Herba speranskiae tuberculatae and Folium Ilicis Purpureae, pulverizing as soaking after powder, then boiling three times with fire: after boiling 2.5 hours with fire, filter, after filtering residue boils 2 hours, filter, filtering residue boils 1.5 hours again, filters, merging filtrate, be condensed into extractum, dry, pulverize as powder; Get B group medicine: Herba Lycopodii, Herba Aristolochiae Mollissimae, Flos Carthami, Olibanum, Myrrha, Fructus Piperis and Borneolum Syntheticum, pulverize as powder, cross 120 mesh sieves;
(2) preparation of substrate: get Colophonium and Oleum Sesami and be brewed into oily (dripping in water inlet in pearl),, pour into after cooling in cold water and stir repeatedly, 3 days releasing fire-toxin (when can avoid pasting allergy) in agglomerating rear immersion water, and every day change a clear water, wherein the mass ratio of Colophonium and Oleum Sesami is 3:1;
(3) mixing of spice: the substrate that step (2) obtains is got and is heated to 60 ~ 70 DEG C, by the powder obtained by A group medicine in step (1), the powder obtained by B group medicine and adjuvant, the powder that A group medicine obtains and the gross weight of powder obtained by B group medicine and the weight ratio of substrate are: 6.5:10, mix in the substrate after heating.
Using method: be spread out on anti-anaphylaxis cloth by the pharmaceutical composition of obtained treatment osseous arthritis, form plaster, often opening plaster content of dispersion is 20 grams.Plaster is overlying on and is then overlying on patient's appearance acupuncture point or affected part.Often open plaster 5 days, three is a course for the treatment of.
The symptom of osseous arthritis and feature:
1, pain is the cardinal symptom of primary disease, is also cause handicapped main cause.
2, morning, deadlock felt stiff existence of pointing out synovitis in morning with adhesion, and the time is shorter, is generally no more than 30 minutes.
3, arthroncus is because local bone is loose or exudative synovitis causes.
4, when tenderness and passive pain companion synovitis are oozed out, there is tenderness affected joints local.
5, joint motion snap is common with knee joint.
6, limitation of activity, the formation of hyperosteogeny, cartilage loss, the pain that periarticular muscles spasm and destruction of joint cause.
Curative effect determinate standard
Cure: Clinical symptom and sign disappears completely, joint movement function recovers normal, follows up a case by regular visits to and does not recur for more than 1 year.
Effective: Clinical symptom and sign disappears substantially, arthralgia and the tingle basic alleviation of limbs, joint movement function recovers substantially.
Effective: Clinical symptom and sign all has and obviously alleviates, and can bring out by other reasons, but pain degree is lighter than in the past.
Invalid: Clinical symptom and sign is all without improvement.
The pharmaceutical composition result of use checking of the treatment osseous arthritis of the present embodiment is as follows:
Patients with Cervical Spondylopathy 30 example, prolapse of lumbar intervertebral disc patient 30 example, knee joint patient with bone disease 30 example, different according to the conditions of patients order of severity, after using three to five courses for the treatment of.Clinical test results: cure 70 example, effective 15 example, effective 5 example, stable curative effect, healing person without recurrence, without drug dependence and side effect.
Embodiment 2
The pharmaceutical composition of the treatment osseous arthritis of the present embodiment is made up of the raw material of following parts by weight:
A group medicine:
Lignum Sappan 20g, wood of shiny-leaved yellowhorn 25g, Caulis Sinomenii 12g, Radix Angelicae Sinensis 6g, Fructus Chaenomelis 9g, Rhizoma Cibotii 6g, Rhizoma Drynariae 3g, Radix Angelicae Pubescentis 10g, Radix Cyathulae 10g, Ramulus Cinnamomi 3g, Radix Puerariae 15g, Semen Sinapis Albae 9g, Radix Aconiti 10g, Radix Aconiti Kusnezoffii 5g, Radix Urticae Cannabinae 10g, Herba speranskiae tuberculatae 15g, Folium Ilicis Purpureae 10g;
B group medicine:
Herba Lycopodii 12g, Herba Aristolochiae Mollissimae 10g, Flos Carthami 3g, Olibanum 5g, Myrrha 5g, Fructus Piperis 5g, Borneolum Syntheticum 1.5g.
Adjuvant: azone 2g, infrared ceramic powder 5g.
Its preparation method is as follows:
(1) preparation of active ingredient: get A group medicine: Lignum Sappan, wood of shiny-leaved yellowhorn, Caulis Sinomenii, Radix Angelicae Sinensis, Fructus Chaenomelis, Rhizoma Cibotii, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Cyathulae, Ramulus Cinnamomi, Radix Puerariae, Semen Sinapis Albae, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Urticae Cannabinae, Herba speranskiae tuberculatae and Folium Ilicis Purpureae, pulverizing as soaking after powder, then boiling three times with fire: after boiling 2.5 hours with fire, filter, after filtering residue boils 2 hours, filter, filtering residue boils 1.5 hours again, filters, merging filtrate, be condensed into extractum, dry, pulverize as powder; Get B group medicine: Herba Lycopodii, Herba Aristolochiae Mollissimae, Flos Carthami, Olibanum, Myrrha, Fructus Piperis and Borneolum Syntheticum, pulverize as powder, cross 120 mesh sieves;
(2) preparation of substrate: get Colophonium and Oleum Sesami and be brewed into oily (dripping in water inlet in pearl), pour into after cooling in cold water and stir repeatedly, 3 days releasing fire-toxin in agglomerating rear immersion water, and change a clear water every day, wherein the mass ratio of Colophonium and Oleum Sesami is 3:1;
(3) mixing of spice: the substrate that step (2) obtains is heated to 60 ~ 70 DEG C, by the powder obtained by A group medicine in step (1), the powder obtained by B group medicine and adjuvant, the powder that A group medicine obtains and the gross weight of powder obtained by B group medicine and the weight ratio of substrate are: 8:10, mix in the substrate after heating.
Using method: be spread out on anti-anaphylaxis cloth by the pharmaceutical composition of obtained treatment osseous arthritis, form plaster, often opening plaster content of dispersion is 20 grams.Plaster is overlying on and is then overlying on patient's appearance acupuncture point or affected part.Often open plaster 5 days, three is a course for the treatment of.
The pharmaceutical composition result of use checking of the treatment osseous arthritis of the present embodiment is as follows:
Patients with Cervical Spondylopathy 29 example, prolapse of lumbar intervertebral disc patient 33 example, knee joint patient with bone disease 28 example, different according to the conditions of patients order of severity, after using three to five courses for the treatment of.Clinical test results: cure 66 example, effective 16 example, effective 4 example, stable curative effect, healing person without recurrence, without drug dependence and side effect.
Embodiment 3
The pharmaceutical composition of the treatment osseous arthritis of the present embodiment is made up of the raw material of following parts by weight:
A group medicine:
Lignum Sappan 30g, wood of shiny-leaved yellowhorn 15g, Caulis Sinomenii 6g, Radix Angelicae Sinensis 12g, Fructus Chaenomelis 6g, Rhizoma Cibotii 12g, Rhizoma Drynariae 9g, Radix Angelicae Pubescentis 3g, Radix Cyathulae 5g, Ramulus Cinnamomi 10g, Radix Puerariae 10g, Semen Sinapis Albae 3g, Radix Aconiti 5g, Radix Aconiti Kusnezoffii 10g, Radix Urticae Cannabinae 15g, Herba speranskiae tuberculatae 9g, Folium Ilicis Purpureae 15g;
B group medicine:
Herba Lycopodii 3g, Herba Aristolochiae Mollissimae 20g, Flos Carthami 10g, Olibanum 3g, Myrrha 3g, Fructus Piperis 3g, Borneolum Syntheticum 3g.
Adjuvant: azone 4g, infrared ceramic powder 7g.
Its preparation method is as follows:
(1) preparation of active ingredient: get A group medicine: Lignum Sappan, wood of shiny-leaved yellowhorn, Caulis Sinomenii, Radix Angelicae Sinensis, Fructus Chaenomelis, Rhizoma Cibotii, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Cyathulae, Ramulus Cinnamomi, Radix Puerariae, Semen Sinapis Albae, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Urticae Cannabinae, Herba speranskiae tuberculatae and Folium Ilicis Purpureae, pulverizing as soaking after powder, then boiling three times with fire: after boiling 2.5 hours with fire, filter, after filtering residue boils 2 hours, filter, filtering residue boils 1.5 hours again, filters, merging filtrate, be condensed into extractum, dry, pulverize as powder; Get B group medicine: Herba Lycopodii, Herba Aristolochiae Mollissimae, Flos Carthami, Olibanum, Myrrha, Fructus Piperis and Borneolum Syntheticum, pulverize as powder, cross 120 mesh sieves;
(2) preparation of substrate: get Colophonium and Oleum Sesami and be brewed into oily (dripping in water inlet in pearl), pour into after cooling in cold water and stir repeatedly, 3 days releasing fire-toxin in agglomerating rear immersion water, and change a clear water every day, wherein the mass ratio of Colophonium and Oleum Sesami is 3:1;
(3) mixing of spice: the substrate that step (2) obtains is heated to 60 ~ 70 DEG C, by the powder obtained by A group medicine in step (1), the powder obtained by B group medicine and adjuvant, the powder that A group medicine obtains and the gross weight of powder obtained by B group medicine and the weight ratio of substrate are: 5:10, mix in the substrate after heating.
Using method: be spread out on anti-anaphylaxis cloth by the pharmaceutical composition of obtained treatment osseous arthritis, form plaster, often opening plaster content of dispersion is 20 grams.Plaster is overlying on and is then overlying on patient's appearance acupuncture point or affected part.Often open plaster 5 days, three is a course for the treatment of.
The pharmaceutical composition result of use checking of the treatment osseous arthritis of the present embodiment is as follows:
Patients with Cervical Spondylopathy 25 example, prolapse of lumbar intervertebral disc patient 32 example, knee joint patient with bone disease 33 example, different according to the conditions of patients order of severity, after using three to five courses for the treatment of.Clinical test results: cure 65 example, effective 15 example, effective 5 example, stable curative effect, healing person without recurrence, without drug dependence and side effect.
Embodiment 4
The pharmaceutical composition of the treatment osseous arthritis of the present embodiment is made up of the raw material of following parts by weight:
A group medicine:
Lignum Sappan 20g, wood of shiny-leaved yellowhorn 25g, Caulis Sinomenii 12g, Radix Angelicae Sinensis 6g, Fructus Chaenomelis 9g, Rhizoma Cibotii 6g, Rhizoma Drynariae 3g, Radix Angelicae Pubescentis 10g, Radix Cyathulae 10g, Ramulus Cinnamomi 3g, Radix Puerariae 15g, Semen Sinapis Albae 9g, Radix Aconiti 10g, Radix Aconiti Kusnezoffii 5g, Radix Urticae Cannabinae 10g, Herba speranskiae tuberculatae 15g, Folium Ilicis Purpureae 10g;
B group medicine:
Herba Lycopodii 12g, Herba Aristolochiae Mollissimae 10g, Flos Carthami 3g, Olibanum 5g, Myrrha 5g, Fructus Piperis 5g, Borneolum Syntheticum 1.5g.
Its preparation method is as follows:
(1) preparation of active ingredient: get A group medicine: Lignum Sappan, wood of shiny-leaved yellowhorn, Caulis Sinomenii, Radix Angelicae Sinensis, Fructus Chaenomelis, Rhizoma Cibotii, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Cyathulae, Ramulus Cinnamomi, Radix Puerariae, Semen Sinapis Albae, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Urticae Cannabinae, Herba speranskiae tuberculatae and Folium Ilicis Purpureae, pulverizing as soaking after powder, then boiling three times with fire: after boiling 2.5 hours with fire, filter, after filtering residue boils 2 hours, filter, filtering residue boils 1.5 hours again, filters, merging filtrate, be condensed into extractum, dry, pulverize as powder; Get B group medicine: Herba Lycopodii, Herba Aristolochiae Mollissimae, Flos Carthami, Olibanum, Myrrha, Fructus Piperis and Borneolum Syntheticum, pulverize as powder, cross 120 mesh sieves;
(2) preparation of substrate: get Colophonium and Oleum Sesami and be brewed into oily (dripping in water inlet in pearl), pour into after cooling in cold water and stir repeatedly, 3 days releasing fire-toxin in agglomerating rear immersion water, and change a clear water every day, wherein the mass ratio of Colophonium and Oleum Sesami is 3:1;
(3) mixing of spice: the substrate that step (2) obtains is heated to 60 ~ 70 DEG C, by the powder obtained by A group medicine in step (1) and the powder obtained by B group medicine, the powder that A group medicine obtains and the gross weight of powder obtained by B group medicine and the weight ratio of substrate are: 6.5:10, mix in the substrate after heating.
Using method: be spread out on anti-anaphylaxis cloth by the pharmaceutical composition of obtained treatment osseous arthritis, form plaster, often opening plaster content of dispersion is 20 grams.Plaster is overlying on and is then overlying on patient's appearance acupuncture point or affected part.Often open plaster 5 days, three is a course for the treatment of.
The pharmaceutical composition result of use checking of the treatment osseous arthritis of the present embodiment is as follows:
Patients with Cervical Spondylopathy 32 example, prolapse of lumbar intervertebral disc patient 34 example, knee joint patient with bone disease 24 example, different according to the conditions of patients order of severity, after using three to five courses for the treatment of.Clinical test results: cure 63 example, effective 14 example, effective 4 example, stable curative effect, healing person without recurrence, without drug dependence and side effect.
Embodiment 5
The pharmaceutical composition of the treatment osseous arthritis of the present embodiment is made up of the raw material of following parts by weight:
A group medicine:
Lignum Sappan 15g, wood of shiny-leaved yellowhorn 20g, Caulis Sinomenii 5g, Radix Angelicae Sinensis 12g, Fructus Chaenomelis 10g, Rhizoma Cibotii 15g, Rhizoma Drynariae 7g, Radix Angelicae Pubescentis 10g, Radix Cyathulae 5g, Ramulus Cinnamomi 15g, Radix Puerariae 12g, Semen Sinapis Albae 9g, Radix Aconiti 10g, Radix Aconiti Kusnezoffii 5g, Radix Urticae Cannabinae 8g, Herba speranskiae tuberculatae 15g, Folium Ilicis Purpureae 5g;
B group medicine:
Herba Lycopodii 15g, Herba Aristolochiae Mollissimae 10g, Flos Carthami 3g, Olibanum 3g, Myrrha 5g, Fructus Piperis 8g, Borneolum Syntheticum 1.5g.
Adjuvant: azone 2g, infrared ceramic powder 5g.
Its preparation method is as follows:
(1) preparation of active ingredient: get A group medicine: Lignum Sappan, wood of shiny-leaved yellowhorn, Caulis Sinomenii, Radix Angelicae Sinensis, Fructus Chaenomelis, Rhizoma Cibotii, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Cyathulae, Ramulus Cinnamomi, Radix Puerariae, Semen Sinapis Albae, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Urticae Cannabinae, Herba speranskiae tuberculatae and Folium Ilicis Purpureae, pulverizing as soaking after powder, then boiling three times with fire: after boiling 2.5 hours with fire, filter, after filtering residue boils 2 hours, filter, filtering residue boils 1.5 hours again, filters, merging filtrate, be condensed into extractum, dry, pulverize as powder; Get B group medicine: Herba Lycopodii, Herba Aristolochiae Mollissimae, Flos Carthami, Olibanum, Myrrha, Fructus Piperis and Borneolum Syntheticum, pulverize as powder, cross 120 mesh sieves;
(2) preparation of substrate: get Colophonium and Oleum Sesami and be brewed into oily (dripping in water inlet in pearl), pour into after cooling in cold water and stir repeatedly, 3 days releasing fire-toxin in agglomerating rear immersion water, and change a clear water every day, wherein the mass ratio of Colophonium and Oleum Sesami is 3:1;
(3) mixing of spice: the substrate that step (2) obtains is heated to 60 ~ 70 DEG C, by the powder obtained by A group medicine in step (1), the powder obtained by B group medicine and adjuvant, the powder that A group medicine obtains and the gross weight of powder obtained by B group medicine and the weight ratio of substrate are: 7:10, mix in the substrate after heating.
Using method: be spread out on anti-anaphylaxis cloth by the pharmaceutical composition of obtained treatment osseous arthritis, form plaster, often opening plaster content of dispersion is 20 grams.Plaster is overlying on and is then overlying on patient's appearance acupuncture point or affected part.Often open plaster 5 days, three is a course for the treatment of.
The pharmaceutical composition result of use checking of the treatment osseous arthritis of the present embodiment is as follows:
Patients with Cervical Spondylopathy 27 example, prolapse of lumbar intervertebral disc patient 33 example, knee joint patient with bone disease 30 example, different according to the conditions of patients order of severity, after using three to five courses for the treatment of.Clinical test results: cure 55 example, effective 18, effective 7 example, stable curative effect, healing person without recurrence, without drug dependence and side effect.
The above embodiment is only that protection scope of the present invention is not limited thereto in order to absolutely prove the preferred embodiment that the present invention lifts.The equivalent alternative or conversion that those skilled in the art do on basis of the present invention, all within protection scope of the present invention.Protection scope of the present invention is as the criterion with claims.

Claims (10)

1. treat a pharmaceutical composition for osseous arthritis, it is characterized in that, be made up of the raw material comprising following active ingredient:
Lignum Sappan, wood of shiny-leaved yellowhorn, Caulis Sinomenii, Radix Angelicae Sinensis, Fructus Chaenomelis, Rhizoma Cibotii, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Cyathulae, Ramulus Cinnamomi, Radix Puerariae, Semen Sinapis Albae, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Urticae Cannabinae, Herba speranskiae tuberculatae, Folium Ilicis Purpureae; Herba Lycopodii, Herba Aristolochiae Mollissimae, Flos Carthami, Olibanum, Myrrha, Fructus Piperis, Borneolum Syntheticum.
2. the pharmaceutical composition for the treatment of osseous arthritis according to claim 1, is characterized in that, described raw material also comprises adjuvant: azone and infrared ceramic powder.
3. the pharmaceutical composition for the treatment of osseous arthritis according to claim 1, is characterized in that, is made up of the raw material of the active ingredient comprising following parts by weight:
Lignum Sappan 20-30, wood of shiny-leaved yellowhorn 15-25, Caulis Sinomenii 6-12, Radix Angelicae Sinensis 6-12, Fructus Chaenomelis 6-9, Rhizoma Cibotii 6-12, Rhizoma Drynariae 3-9, Radix Angelicae Pubescentis 3-10, Radix Cyathulae 5-10, Ramulus Cinnamomi 3-10, Radix Puerariae 10-15, Semen Sinapis Albae 3-9, Radix Aconiti 5-10, Radix Aconiti Kusnezoffii 5-10, Radix Urticae Cannabinae 10-15, Herba speranskiae tuberculatae 9-15, Folium Ilicis Purpureae 10-15; Herba Lycopodii 3-12, Herba Aristolochiae Mollissimae 10-20, Flos Carthami 3-10, Olibanum 3-5, Myrrha 3-5, Fructus Piperis 3-5, Borneolum Syntheticum 1.5-3.
4. the pharmaceutical composition for the treatment of osseous arthritis according to claim 3, is characterized in that, described raw material also comprises the adjuvant of following parts by weight: azone 2 ~ 4, infrared ceramic powder 5 ~ 7.
5. the preparation method of the pharmaceutical composition of the treatment osseous arthritis described in claim 1 or 3, is characterized in that, comprise the steps:
(1) preparation of active ingredient: get A group medicine: Lignum Sappan, wood of shiny-leaved yellowhorn, Caulis Sinomenii, Radix Angelicae Sinensis, Fructus Chaenomelis, Rhizoma Cibotii, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Cyathulae, Ramulus Cinnamomi, Radix Puerariae, Semen Sinapis Albae, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Urticae Cannabinae, Herba speranskiae tuberculatae and Folium Ilicis Purpureae, pulverize, soak, then boil with fire, filter, filtrate is condensed into extractum, dries, pulverizes as powder; Get B group medicine: Herba Lycopodii, Herba Aristolochiae Mollissimae, Flos Carthami, Olibanum, Myrrha, Fructus Piperis and Borneolum Syntheticum, pulverize as powder;
(2) preparation of substrate: get Colophonium and Oleum Sesami is brewed into oily, obtains substrate;
(3) mixing of spice: substrate heating step (2) obtained, mixes the powder obtained by A group medicine in step (1) and the powder that obtained by B group medicine in the substrate after heating.
6. the preparation method of the pharmaceutical composition of the treatment osseous arthritis described in claim 2 or 4, is characterized in that, comprise the steps:
(1) preparation of active ingredient: get A group medicine: Lignum Sappan, wood of shiny-leaved yellowhorn, Caulis Sinomenii, Radix Angelicae Sinensis, Fructus Chaenomelis, Rhizoma Cibotii, Rhizoma Drynariae, Radix Angelicae Pubescentis, Radix Cyathulae, Ramulus Cinnamomi, Radix Puerariae, Semen Sinapis Albae, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Urticae Cannabinae, Herba speranskiae tuberculatae and Folium Ilicis Purpureae, pulverize, soak, then boil with fire, filter, filtrate is condensed into extractum, dries, pulverizes as powder; Get B group medicine: Herba Lycopodii, Herba Aristolochiae Mollissimae, Flos Carthami, Olibanum, Myrrha, Fructus Piperis and Borneolum Syntheticum, pulverize as powder;
(2) preparation of substrate: get Colophonium and Oleum Sesami is brewed into oily, obtains substrate;
(3) mixing of spice: substrate heating step (2) obtained, by the powder obtained by A group medicine in step (1), the powder obtained by B group medicine and azone and infrared ceramic powder, mixes in the substrate after heating.
7. the preparation method according to claim 5 or 6, is characterized in that, soaks after the middle A group medicated powder of step (1) is broken, then three times are boiled with fire: after boiling 2 ~ 3 hours with fire, filter, after filtering residue boils 1.5 ~ 2.5 hours, filter, filtering residue boils 1 ~ 2 hour again, filter, merging filtrate, is condensed into extractum, dry, pulverize as powder.
8. the preparation method according to claim 5 or 6, is characterized in that, in step (2), the mass ratio of Colophonium and Oleum Sesami is 1:1 ~ 5:1.
9. the preparation method according to claim 5 or 6, is characterized in that, after in step (2), Colophonium and Oleum Sesami are brewed into oily, cooling, is poured into water, and stirs, soaks more than 10 hours.
10. the preparation method according to claim 5 or 6, is characterized in that, substrate is heated to 60 ~ 70 DEG C in (3) by step; The powder that A group medicine obtains and the gross weight of powder obtained by B group medicine and the weight ratio of substrate are: 5 ~ 8:10.
CN201610057826.0A 2016-01-28 2016-01-28 Medicine composition for treating osteoartritis and preparation method thereof Pending CN105560537A (en)

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CN107050180A (en) * 2017-04-26 2017-08-18 内蒙古医科大学 A kind of wood of shiny-leaved yellowhorn preparation and preparation method thereof

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CN104147542A (en) * 2014-08-29 2014-11-19 韩世昌 Plaster for treating rheumatic rheumatoid arthritis, and preparation method thereof
CN104324343A (en) * 2014-09-09 2015-02-04 韩世昌 Traditional Chinese medicinal ointment for treating femoral head necrosis, and preparation method thereof

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CN1966042A (en) * 2006-09-22 2007-05-23 任景全 Externally applied ointment for treating hyperosteogeny and preparation method thereof
CN104147542A (en) * 2014-08-29 2014-11-19 韩世昌 Plaster for treating rheumatic rheumatoid arthritis, and preparation method thereof
CN104324343A (en) * 2014-09-09 2015-02-04 韩世昌 Traditional Chinese medicinal ointment for treating femoral head necrosis, and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107050180A (en) * 2017-04-26 2017-08-18 内蒙古医科大学 A kind of wood of shiny-leaved yellowhorn preparation and preparation method thereof

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Application publication date: 20160511