CN102895460B - Traditional Chinese medicine composition for fracture and soft tissue injury - Google Patents
Traditional Chinese medicine composition for fracture and soft tissue injury Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for fracture and soft tissue injury and a preparation method thereof. The composition is prepared from the following raw materials, by weight: 25 parts of muskmelon seeds, 20 parts of angelica, 20 parts of Radix Paeoniae, 20 parts of nux vomica, 18 parts of garden balsam stem, 18 parts of safflower, 15 parts of suberect spatholobus stem, 15 parts of epimedium, 15 parts of pseudo-ginseng, 12 parts of licorice, 12 parts of Astragalus, 10 parts of radix sileris, 10 parts of herba lycopi, 9 parts of yam, 8 parts of eucommia, 7 parts of cassia twig, 5 parts of teasel root, 5 parts of drynaria rhizome, 5 parts of peach kernel and 3 parts of dragon's blood. The traditional Chinese medicine composition provided by the invention treates both symptoms and root causes of fracture and soft tissue injury, and has no toxicity or harm to human body, no side effect, low price, simple production and a broad application prospect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to and a kind ofly treat Chinese medicine composition of the traumatic injury such as fracture, soft tissue injury and preparation method thereof.
Background technology
Fracture and soft tissue injury are the commonly encountered diseases of traumatology, and fracture means a kind of disease because the reason such as wound or pathology causes bone parts ground or fully ruptures.Its main clinical manifestation is: fractures has localized pain and tenderness, local swelling and occur ecchymosis, limb function position or completely lose, and complete fracture still can occur cacomelia and abnormal movement.Mean soft tissue injury various acute trauma or the reason such as chronic strain and oneself disease pathology cause the pathological lesion of the tissues such as the skin of human body, subcutaneous shallow deep fascia, muscle, tendon, stndon sheath, ligament, joint capsule, synovial bursae, intervertebral disc, peripheral nerve blood vessel, its clinical manifestation is: pain, swelling, deformity, dysfunction.
Fracture and soft tissue injury are the bone injury disease of the traditional Chinese medical science, and belong to passages through which vital energy circulates injured, QI and blood is impaired more, hemorrhage, and the stasis of blood is long-pending does not fall apart, the disease of swelling pain.All have in stagnant blood stay, blood stasis stagnate, passages through which vital energy circulates obstructed or run not smooth.Blood stasis does not go, fresh blood not life, and newborn fresh blood can not to pacify row in good health, eventually must absurd row and cause change disease multiterminal.Its main pathology is that congestion is stopped up stagnant, and blood is held one's breath resistance, therefore with pain, swelling for main manifestations.The suitable circulation of qi promoting for the treatment of, dissipating blood stasis, invigorates blood circulation, pain relieving, relaxing muscles and tendons, and hard bone is main.After right patient's traumatic injury, all oil preparation for promoting blood circulation persons of rubbing, hemorrhage aggravation, pain, swelling are more acute, and damage is to dark; Oral anti-inflammation analgesic is serious to gastric injury, and particularly patients with gastric disease can not tolerate; Transfusion is easily irritated, and costly, patient suffering, uses inconvenience, and Western medicine equal existing defects in safety and dependency, side effect is also relatively large, and easy shape is additive, drug resistance, therefore should not take for a long time.
Motherland's medical science is in treatment traumatic fracture, and there is the curative effect of its uniqueness the disease aspects such as soft tissue injury, according to " harmony between man and nature, integration of edible and medicinal herbs in the philosophic thinking of the materialistic dialectics and Chinese medicine; Dialectically to treat, treating both the principal and secondary aspects of a disease, inside and outside rule together; Muscles and bones is laid equal stress on, and is association of activity and inertia; Liver governing tendons, kidney governing bones, invigorating the liver and kidney, bone and muscle strengthening; The meridian dredging, damp eliminating numbness, relaxing muscles and tendons arteries and veins, detumescence pain, sharp joint; The stagnation of QI is blood stasis, the capable then blood of gas then; Stagnation of QI and blood may bring about pain, general rule are not bitterly; Discontinue medication as soon as get effect " most important theories.In conjunction with the Therapeutic Method of modern medicines component analysis with the science of grasp.Emphasis is strengthened the effect of body Integrate adjustment, promotes osteocyte to generate and propagation, is conducive to growth of spur and flexural capacity, promote union of fracture, soft tissue injury compound, reach the therapeutic purposes that reducing swelling and alleviating pain, muscles and bones are strong.
Exist for fracturing in prior art, the Chinese medicine of soft tissue injury, comprising there being Chinese medicine for oral administration, but only its curative effect for oral administration is very undesirable; In addition, also have some varnish or plaster etc. of external, also there is the problem that some are such or such, can have side effects to human body, as erythra etc. after some uses; Also having for oral administration use that combines with external, there is the more complicated weak point of use procedure in this kind of medicine.Therefore, research and develop a kind of high-efficiency low-toxicity, the new Chinese medicine for the treatment of both the principal and secondary aspects of a disease is the technical barrier being still this area.
Summary of the invention
The object of the invention is the deficiency in order to overcome background technology, and a kind of easy to use, cheap, the Traditional Chinese medicine composition formula that treating both the principal and secondary aspects of a disease, treatment cycle are short that provide.Present inventor in conjunction with secret prescription handed down in the family from generation to generation according to forefathers' experience and oneself medical practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect the length of many families, based on external treatment with Chinese medicine, seek therapeutic regimen, adopt natural Chinese medicines raw material, meticulously be mixed with the Chinese medicine composition for the treatment of fracture of the present invention, soft tissue injury in conjunction with Traditional Chinese Medicine technology, its compound method is simple, to the effect of fracturing, soft tissue injury has healing.
For achieving the above object, the technical solution used in the present invention is as follows:
Treat a Chinese medicine composition for fracture and soft tissue injury, it is prepared than raw material by following weight and obtains,
Semen Melo 25 parts, Radix Angelicae Sinensis 20 parts, Radix Paeoniae Rubra 20 parts, Semen Strychni 20 parts, Herba speranskiae tuberculatae 18 parts,
18 parts, Flos Carthami, Caulis Spatholobi 15 parts, Herba Epimedii 15 parts, Radix Notoginseng 15 parts, 12 parts, Radix Glycyrrhizae,
The Radix Astragali 12 parts, Radix Saposhnikoviae 10 parts, Herba Lycopi 10 parts, Rhizoma Dioscoreae 9 parts, the Cortex Eucommiae 8 parts,
Ramulus Cinnamomi 7 parts, Radix Dipsaci 5 parts, Rhizoma Drynariae 5 parts, 5 parts, Semen Persicae, Sanguis Draxonis 3 parts.
Pharmaceutical composition its preparation method of the present invention is: according to raw material mass mixture ratio weighting raw materials, make powder respectively according to a conventional method, cross 80-100 mesh sieve stand-by, by whole medicated powder Homogeneous phase mixing together, wide mouth glass bottle is put in mixing, for subsequent use, namely become the Chinese medicine powder that the present invention treats fracture, soft tissue injury, each 5-10 gram, every day 2-3 time, take after mixing it with water with yellow wine, a course for the treatment of two Mondays, take 2-3 the course for the treatment of continuously.
Chinese medicine composition of the present invention also can be made into pill, and its method is, crude drug is made medicated powder according to a conventional method respectively, cross 80 mesh sieves, take in proportion, mixing, every 100g adds refined honey 40g and 10g water, general ball, the heavy 10g of every ball is dry, namely pill is made, an oral ball at every turn two weeks is a course for the treatment of, takes 2-3 the course for the treatment of.Also according to this area conventional method, the pharmaceutical composition of the application can be prepared into capsule, tablets and other formulations.
Formula feature of the present invention: act on cooperative compensating between Chinese medicine, plays effect of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, reunion of bone altogether., muscles and bones smooth through ruton, QI and blood can be made to supplement nutrition, promote growth of spur, accelerating union of bone fracture, have significant curative effect to treatment bone does not connect, through adjunctive treatment of bone fracture, can healing time be shortened, can bone does not connect be prevented again.Pharmaceutical compositions of the present invention can be divided into two classes, and a class is blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds, to remove pathogen; Another kind of is invigorating the liver and kidney, benefiting essence-blood, nourish the capable effect that it moistens of space between skin and muscles, thus make that delayed union of fracture, fracture fixation operations infection of bone, soft tissue injury and joint dislocation disease QI and blood are unobstructed, swelling can disappear, pain must be separated, its muscles and bones, restore funcitons by force.
Function cures mainly: removing toxic substances and promoting subsidence of swelling, pain relieving granulation promoting.Treat various traumatic injury red swelling of the skin extremely, fracture, soft tissue sprain.
Points for attention: 1., the more serious patient of damage comprises fracture, dislocation and open injury patient, should use or in hospital symptomatic treatment under physician guidance;
2., damage location at lower limb, should lie up;
3., the hot thing such as fasting beef, the flesh of fish, wine and Fructus Capsici Rhizoma Zingiberis Recens Bulbus Allii.
Advantage of the present invention:
This product energy stasis-dispelling and pain-killing fast, congestive edema gradually disappears and takes off, and within about three to five days, can walk;
The cost of material is low for medical raw, and existing good economic benefit can alleviate again the financial burden of patient, and prescription is in order reasonable, and drug effect is deeply lasting, and medicine is simple and power is special;
By the choose reasonable to medicine components, proportioning, achieve desirable therapeutic effect, both met state-promulgated pharmacopoeia to the requirement about drug dose, good therapeutic effect can have been ensured again, non-evident effect.
Detailed description of the invention
Embodiment 1
Treat a Chinese medicine composition for fracture and soft tissue injury, it is prepared than raw material by following weight and obtains,
Semen Melo 25 parts, Radix Angelicae Sinensis 20 parts, Radix Paeoniae Rubra 20 parts, Semen Strychni 20 parts, Herba speranskiae tuberculatae 18 parts,
18 parts, Flos Carthami, Caulis Spatholobi 15 parts, Herba Epimedii 15 parts, Radix Notoginseng 15 parts, 12 parts, Radix Glycyrrhizae,
The Radix Astragali 12 parts, Radix Saposhnikoviae 10 parts, Herba Lycopi 10 parts, Rhizoma Dioscoreae 9 parts, the Cortex Eucommiae 8 parts,
Ramulus Cinnamomi 7 parts, Radix Dipsaci 5 parts, Rhizoma Drynariae 5 parts, 5 parts, Semen Persicae, Sanguis Draxonis 3 parts.
Pharmaceutical composition its preparation method of the present invention is: according to raw material mass mixture ratio weighting raw materials, make powder respectively according to a conventional method, cross 80-100 mesh sieve stand-by, by whole medicated powder Homogeneous phase mixing together, wide mouth glass bottle is put in mixing, for subsequent use, namely become the Chinese medicine powder that the present invention treats fracture, soft tissue injury, each 5 grams, every day 3 times, take after mixing it with water with yellow wine, a course for the treatment of two Mondays, take 2-3 the course for the treatment of continuously.
Drug action:
Analgesic test
Hot plate induced pain method gets 18-20g kunming mice 20, is placed in constant temperature [(55 ± 0.5) DEG C] water-bath.Hot plate measures the threshold of pain, and the screening threshold of pain is 10 ~ 30s mice 20, random point 2 groups, blank group and medicine group gastric infusion (0.5g) of the present invention, and after medicine, 0.5h, 1h, 2h survey the threshold of pain respectively, and result shows that the present invention has significant analgesic activity;
Table 1 medicine of the present invention is on the impact of mouse hot-plate induced pain
Compare with normal saline,
*p < 0.05
Writhing assay:
Kunming mice 20, be divided into 2 groups at random, every day is administered once, continuous gastric infusion 5 days, after last gastric infusion 1h, lumbar injection 0.6% glacial acetic acid 0.2ml/ only, observes mouse writhing number of times in 20min, can find that medicine of the present invention obviously reduces glacial acetic acid induced mice writhing frequency.
Table 2 medicine of the present invention is on the impact of mouse writhing number of times
| Group | Mice number (only) | Writhing number of times (20min) |
| Normal saline group | 10 | 30.32±5.71 |
| Medicine group of the present invention | 10 | 16.52±3.48 |
Embodiment 2
Clinical data
From fracture to our hospital in recent years and soft tissue injury case, select 96 examples, be divided into treatment group and matched group at random, in two groups of cases selected, medical history, the state of an illness, age, sex are as far as possible quite, and are hospitalization.Treatment group 48 example, age 25-58 year, 37 years old mean age.Wherein fracture 25 example, soft tissue injury 23 example.Matched group 48 example, age 21-60 year, 39 years old mean age, wherein fracture 24 example, soft tissue injury 24 example.
Treatment group takes the Chinese medicine composition for the treatment of fracture of the present invention, soft tissue injury, each 5 grams, takes after mixing it with water with yellow wine, every day 3 times, a course for the treatment of two Mondays.Matched group adopts conventional Radix Notoginseng Tabellae treatment, one time 2,3 times on the one, within two weeks, be a course for the treatment of, observe therapeutic effect at any time, affected part swelling regression time, within every 7 days, take the photograph sheet once, check para-position and growth of spur situation and suffering limb functional rehabilitation time.
Criterion of therapeutical effect: be divided into healing, improvement, invalid three grades
Curative effect of fracture criterion, cure: fracture satisfied to line para-position, have seriality callus formation, the broken ends of fractured bone is without tenderness, and nothing impacts pain, functional rehabilitation.Take a turn for the better: para-position and to line still can, or fracture reduction is not good, but functional rehabilitation is fair.Invalid: nonunion synthesis local obviously deformity, dysfunction.
Soft tissue injury curative effect judging standard: cure: pain, swelling, ecchymosis disappear, and functional rehabilitation is normal.Take a turn for the better: pain, swelling disappear, and function is obviously improved, but affected part still has discomfort.Invalid: symptom, function sign are all without improvement.
Therapeutic outcome:
Fracture patient medication 2 weeks, under x-ray, visible callus accounts for 85%, medication 3 weeks, and under x-ray, visible callus accounts for 90%, and than need not the general conventional therapy of Chinese medicine composition of the present invention, corresponding treatment time advance 1 times appears in callus.
Simple soft tissue falls, beat, sprain from medication to functional rehabilitation be administration time.Average administration time is one week, subsides a swelling completely, without pain.Than need not the general conventional therapy of Chinese medicine composition of the present invention, functional rehabilitation, effectively needs 2-4 week, and time advance 2-4 doubly.
Two groups of therapeutic outcomes (P < 0.01) as follows:
| Group | Example time | Cure | Take a turn for the better | Invalid | Total effective rate |
| Treatment group | 48 | 35 | 10 | 3 | 93.75％ |
| Matched group | 48 | 28 | 14 | 6 | 87.5％ |
The obvious effective rate of two groups is respectively 93.75% and 87.5%, has significant difference.
Embodiment 3
Exemplary embodiments
High certain, man, 27 years old, main suit's 3 years causes were fallen by motorcycle, and waist is injured, left side pain, and through medical treatment, apply with medical herbs, lumbago took a turn for the better to some extent at that time, and when sending out during midway only, lumbago of raining, bid in plaster is from pasting to no effect.Most immediate cause is played basketball, and sprain, lumbago is inactive, left side pain severe.The hospital of traditional Chinese hospital is gone to do acupuncture, massage repeatedly, poor effect.Present seat, all pains of bending over, also pain is stood up in sleep, and activity is obstructed.Admission examination: lumbar vertebra 3/4 presses pain, lumbar vertebra both sides soft tissue rope strip and lump, be diagnosed as waist old injury and waist soft tissue sprain, takes pharmaceutical composition prepared by embodiment 1, every day 3 times, each 5 grams, take after mixing it with water with yellow wine.After one week, check pain disappears substantially, and freely, advise and continue to take one week, patient main suit recovers completely in activity, and through above-mentioned treatment two weeks, transference cure, frequentation was not recurred so far.
Hu, male, 50 years old, because vehicle accident is caused injury.Clinical diagnosis: the open syntripsis of bilateral distal tibiofibular, left leg anterior tibial muscle tendon ruptures, left leg skin contusion.Row left leg wound debridement and suturing, anterior tibial muscle tendon coincide, bilateral distal tibiofibular syntripsis open reduction locking steel plate internal fixtion, the treatments such as left leg Gypsum Fibrosum extenal fixation.Within postoperative 3rd day, start the Chinese medicine composition taking embodiment 1 preparation, every day 3 times, each 5 grams, take after mixing it with water with yellow wine, after taking a course for the treatment of, the swelling of bilateral shank is disappeared, and pain symptom disappears.Within postoperative 20th day, remove Gypsum Fibrosum extenal fixation, sick bed carries out SCID Mice and bend and stretch functional activity.After taking two courses for the treatment of, x-ray inspection, bilateral distal tibiofibular fracture position is without growth of spur; Continue to take two courses for the treatment of, x-ray inspection, a small amount of growth of spur in two distal tibiofibular fracture positions, fracture line is still more clear; After continuing to take two courses for the treatment of, x-ray inspection, there is a large amount of growth of spur at two distal tibiofibular fracture position, and fracture line is fuzzy and disappear.Meet clinical union of bone standard, weight-bearing walking on ground, and recover normal work gradually.
Above-mentioned each Chinese medicine that the present invention adopts makes compatibility mutually, its collaborative effect of curing the disease can be played, there is between each composition of raw material of Chinese medicine used drug effect be interweaved and mutually promote and coordinate usefulness, through clinical verification, fracture and soft tissue injury are had to effect of healing, can relaxing muscles and tendons and activating QI and blood in the collateral, promoting tissue regeneration by removing blood stasis, hemostasis and pain-relieving, in the applicant's medical practice for many years, the case Numerous of healing, all obtains good effect, and with low cost, alleviate the burden of patient.
The Chinese medicine composition that the application is used for the treatment of fracture and soft tissue injury is with low cost, evident in efficacy, has broad application prospects.
Claims (1)
1., for fracturing and the Chinese medicine composition of soft tissue injury, it is characterized in that it is prepared by following weight proportioning raw material and obtains, Semen Melo 25 parts, Radix Angelicae Sinensis 20 parts, Radix Paeoniae Rubra 20 parts, Semen Strychni 20 parts, Herba speranskiae tuberculatae 18 parts,
18 parts, Flos Carthami, Caulis Spatholobi 15 parts, Herba Epimedii 15 parts, Radix Notoginseng 15 parts, 12 parts, Radix Glycyrrhizae,
The Radix Astragali 12 parts, Radix Saposhnikoviae 10 parts, Herba Lycopi 10 parts, Rhizoma Dioscoreae 9 parts, the Cortex Eucommiae 8 parts,
Ramulus Cinnamomi 7 parts, Radix Dipsaci 5 parts, Rhizoma Drynariae 5 parts, 5 parts, Semen Persicae, Sanguis Draxonis 3 parts;
The preparation method of described Chinese medicine composition is: take raw material according to raw material weight proportioning, make powder respectively according to a conventional method, crosses 80-100 mesh sieve stand-by, and by whole medicated powder Homogeneous phase mixing together, wide mouth glass bottle is put in mixing, to obtain final product.
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| CN105343862A (en) * | 2015-12-15 | 2016-02-24 | 张彦英 | Drug composition for soft tissue injury and fracture |
| CN105535166A (en) * | 2016-01-26 | 2016-05-04 | 马同英 | Nursing liquid medicine taken after fracture and preparation method thereof |
| CN108272877A (en) * | 2018-04-26 | 2018-07-13 | 夏战利 | A kind of traumatic injury Chinese drugs agentia |
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