CN105343862A - Drug composition for soft tissue injury and fracture - Google Patents

Drug composition for soft tissue injury and fracture Download PDF

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Publication number
CN105343862A
CN105343862A CN201510935366.2A CN201510935366A CN105343862A CN 105343862 A CN105343862 A CN 105343862A CN 201510935366 A CN201510935366 A CN 201510935366A CN 105343862 A CN105343862 A CN 105343862A
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parts
radix
rhizoma
herba
pharmaceutical composition
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张彦英
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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Abstract

The invention relates to a drug composition for soft tissue injury and fracture. The drug composition is prepared from the following raw materials: angelica sinensis, purple perilla, dandelion, myrrh, root of common peony, lotus seed, pseudo-ginseng, rhizoma zingiberis, honeysuckle, magnolia officinalis, madder, poria cocos, cassia twig, malt, cistanche, prepared rhizome of rehmannia, fructus psoraleae, rhizoma sparganii, rhizoma cyperi, safflower carthamus, garden balsam stem, nux vomica, radices sileris, notopterygium root, radix clematidis, moutan bark, ligusticum wallichii, the seed of Chinese dodder, the root of bidentate achyranthes and schizonepeta. By clinical verifications, a drug preparation stimulates the circulation of the blood and causes the muscles and joints to relax, removes blood stasis for promoting tissue regeneration, is remarkable in curative effect, and has wide application prospects.

Description

A kind of pharmaceutical composition for soft tissue injury, fracture
Technical field
The present invention relates to Chinese medicine technical field, particularly a kind of pharmaceutical composition for soft tissue injury, fracture.
Background technology
Fracture is that the seriality of bone structure ruptures wholly or in part.Be more common in child and old people, young people also happens occasionally.Patient is often-individual position fracture, and minority is multiple fracture.Through appropriate process in time, most patient can recover original function, and a few patients can leave over sequela in various degree.Its main clinical manifestation is: fractures has localized pain and tenderness, local swelling and occur ecchymosis, limb function position or completely lose, and complete fracture still can occur cacomelia and abnormal movement.Mean soft tissue injury various acute trauma or the reason such as chronic strain and oneself disease pathology cause the pathological lesion of the tissues such as the skin of human body, subcutaneous shallow deep fascia, muscle, tendon, stndon sheath, ligament, joint capsule, synovial bursae, intervertebral disc, peripheral nerve blood vessel, its clinical manifestation is: pain, swelling, deformity, dysfunction.
Fracture and soft tissue injury are the bone injury disease of the traditional Chinese medical science, and belong to passages through which vital energy circulates injured, QI and blood is impaired more, hemorrhage, and the stasis of blood is long-pending does not fall apart, the disease of swelling pain.All have in stagnant blood stay, blood stasis stagnate, passages through which vital energy circulates obstructed or run not smooth.Blood stasis does not go, fresh blood not life, and newborn fresh blood can not to pacify row in good health, eventually must absurd row and cause change disease multiterminal.Its main pathology is that congestion is stopped up stagnant, and blood is held one's breath resistance, therefore with pain, swelling for main manifestations.The suitable circulation of qi promoting for the treatment of, dissipating blood stasis, invigorates blood circulation, pain relieving, relaxing muscles and tendons, and hard bone is main.After right patient's traumatic injury, all oil preparation for promoting blood circulation persons of rubbing, hemorrhage aggravation, pain, swelling are more acute, and damage is to dark; Oral anti-inflammation analgesic is serious to gastric injury, and particularly patients with gastric disease can not tolerate; Transfusion is easily irritated, and costly, patient suffering, uses inconvenience, and Western medicine equal existing defects in safety and dependency, side effect is also relatively large, and easy shape is additive, drug resistance, therefore should not take for a long time.
Motherland's medical science is in treatment traumatic fracture, and there is the curative effect of its uniqueness the disease aspects such as soft tissue injury, according to " harmony between man and nature, integration of edible and medicinal herbs in the philosophic thinking of the materialistic dialectics and Chinese medicine; Dialectically to treat, treating both the principal and secondary aspects of a disease, inside and outside rule together; Muscles and bones is laid equal stress on, and is association of activity and inertia; Liver governing tendons, kidney governing bones, invigorating the liver and kidney, bone and muscle strengthening; The meridian dredging, damp eliminating numbness, relaxing muscles and tendons arteries and veins, detumescence pain, sharp joint; The stagnation of QI is blood stasis, the capable then blood of gas then; Stagnation of QI and blood may bring about pain, general rule are not bitterly; Discontinue medication as soon as get effect " most important theories.In conjunction with the Therapeutic Method of modern medicines component analysis with the science of grasp.Emphasis is strengthened the effect of body Integrate adjustment, promotes osteocyte to generate and propagation, is conducive to growth of spur and flexural capacity, promote union of fracture, soft tissue injury compound, reach the therapeutic purposes that reducing swelling and alleviating pain, muscles and bones are strong.
Summary of the invention
The object of the invention is the deficiency in order to overcome background technology, and a kind of easy to use, cheap, union of fracture is fast, treatment cycle the is short Traditional Chinese medicine composition formula that provide.Present inventor in conjunction with secret prescription handed down in the family from generation to generation according to forefathers' experience and oneself medical practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect the length of many families, seek therapeutic regimen, adopt natural Chinese medicines raw material, meticulously be mixed with the pharmaceutical composition for soft tissue injury, fracture of the present invention in conjunction with Traditional Chinese Medicine technology, its compound method is simple, and the medicine prepared by said composition can use in hospital, also can provide for oneself, need the used time to modulate use voluntarily.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of for soft tissue injury, the pharmaceutical composition of fracture, it is prepared from by following raw material medicaments:
Radix Angelicae Sinensis, Folium Perillae, Herba Taraxaci, Myrrha, Radix Paeoniae Rubra, Semen Nelumbinis, Radix Notoginseng, Rhizoma Zingiberis, Flos Lonicerae, Cortex Magnoliae Officinalis, Radix Rubiae, Poria, Ramulus Cinnamomi, Fructus Hordei Germinatus, Herba Cistanches, Radix Rehmanniae Preparata, Fructus Psoraleae, Rhizoma Sparganii, Rhizoma Cyperi, Flos Carthami, Herba speranskiae tuberculatae, Semen Strychni, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Clematidis, Cortex Moutan, Rhizoma Chuanxiong, Semen Cuscutae, Radix Achyranthis Bidentatae, Herba Schizonepetae.
Described pharmaceutical composition is prepared by the raw material of following weight proportioning:
Radix Angelicae Sinensis 35-40 part, Folium Perillae 35-40 part, Herba Taraxaci 35-40 part, Myrrha 35-40 part, Radix Paeoniae Rubra 35-40 part,
Semen Nelumbinis 30-35 part, Radix Notoginseng 30-35 part, Rhizoma Zingiberis 30-35 part, Flos Lonicerae 30-35 part, Cortex Magnoliae Officinalis 30-35 part,
Radix Rubiae 28-30 part, Poria 28-30 part, Ramulus Cinnamomi 28-30 part, Fructus Hordei Germinatus 28-30 part, Herba Cistanches 28-30 part,
Radix Rehmanniae Preparata 25-28 part, Fructus Psoraleae 25-28 part, Rhizoma Sparganii 20-25 part, Rhizoma Cyperi 20-25 part, Flos Carthami 20-25 part,
Herba speranskiae tuberculatae 20-25 part, Semen Strychni 15-20 part, Radix Saposhnikoviae 15-20 part, Rhizoma Et Radix Notopterygii 15-20 part, Radix Clematidis 15-20 part,
Cortex Moutan 15-18 part, Rhizoma Chuanxiong 15-18 part, Semen Cuscutae 15-18 part, Radix Achyranthis Bidentatae 10-15 part, Herba Schizonepetae 10-15 part.
Pharmaceutical composition its preparation method of the present invention is:
(1) for subsequent use according to weight weighting raw materials
(2) get Herba Taraxaci, Myrrha, Semen Nelumbinis, Rhizoma Sparganii, Cortex Moutan difference powder routinely, 100 mesh sieves that sieve are stand-by, then by medicated powder mix homogeneously, prepare complex A;
(3) get Radix Angelicae Sinensis, Folium Perillae, Poria, Ramulus Cinnamomi, Fructus Hordei Germinatus, Herba Cistanches, Semen Strychni, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Schizonepetae decoct with water; first time adds 4 times of weight water; decoct 2 hours; obtain filtrate and medicinal residues after filtration, medicinal residues are added 2 times of weight water and decoct 1 hour, after filtration, obtain filtrate; merge twice filtrate; filtrate after merging is condensed into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverizes and obtain complex B;
(4) get the ethanol that surplus stock adds 3 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverizes and obtains complex C;
(5) Homogeneous phase mixing complex A, B, C, in incapsulating, sterilization obtains capsule product, each oral 0.3g, three times on the one.
A course for the treatment of two Mondays, take 2-3 the course for the treatment of continuously.
Compatibility of drugs of the present invention is reasonable, and uniqueness processed by big gun, technical maturity, and steady quality selects multiple famous and precious high-quality Chinese medicine, is " gold partner ".Having has one's ideas straightened out leads off, dredge the meridian passage, antipyretic calmness; Invigorating vital QI circulation of qi promoting; Blood circulation promoting and enriching, hemostasis passage, nourishing blood; Blood stasis-eliminating and stagnation-dissipating, reducing swelling and alleviating pain; Synthetism bone growth promoting bone strengthening, the continuous strong muscle of muscle relaxing muscles and tendons; Wind-expelling pain-stopping, dehumidify sharp numbness; Easing joint movement, nourishes joint, strong joint; Improve antioxidant ability of organism and immunity moderation ability; Promote blood flow, improve microcirculation; Increase absorbing of calcium, be conducive to osteocyte and generate and propagation, promote growth of spur, promote union of fracture, recover the action character of function of joint.
Traditional Chinese medicine composition formula of the present invention illustrates:
1) indication: cure mainly fracture, ligament, tendon, soft tissue injury.Fracture delayed union, osteoporosis, Avascular Necrosis Of Femur Head, rheumatoid arthritis etc.
2), contraindication:
Pregnant and lying-in women and women breast-feeding their children; Infant and child; Unconsciousness patient; Intracranial hemorrhage patient; Hemophilia and coagulation disorders patient; Primary hyperparathyroidism person; Patients with Urinary Stone; Peptic ulcer does not cure patient; Severe hypertension patient; Serious hepatic renal dysfunction patient.
3), points for attention: take half an hour after meal; Warm water delivery service.
Avoid cold acid, pungent and greasy food; Avoid tobacco and wine; Follow the doctor's advice and carry out function of joint activity and weight-bearing walking on ground;
Clinical observation statistical result proves: the fracture that pharmaceutical preparation of the present invention causes for a variety of causes, bone injury have good therapeutic effect, can accelerate osteanagenesis, good effect.
Detailed description of the invention
Embodiment 1
A kind of for soft tissue injury, the pharmaceutical composition of fracture, is characterized in that being prepared by the raw material of following weight proportioning:
Radix Angelicae Sinensis 35 parts, Folium Perillae 35 parts, Herba Taraxaci 35 parts, Myrrha 35 parts, Radix Paeoniae Rubra 35 parts,
30 parts, Semen Nelumbinis, Radix Notoginseng 30 parts, Rhizoma Zingiberis 30 parts, Flos Lonicerae 30 parts, Cortex Magnoliae Officinalis 30 parts,
28 parts, Radix Rubiae, 28 parts, Poria, Ramulus Cinnamomi 28 parts, 28 parts, Fructus Hordei Germinatus, Herba Cistanches 28 parts,
25 parts, Radix Rehmanniae Preparata, Fructus Psoraleae 25 parts, Rhizoma Sparganii 20 parts, Rhizoma Cyperi 20 parts, 20 parts, Flos Carthami,
Herba speranskiae tuberculatae 20 parts, Semen Strychni 15 parts, Radix Saposhnikoviae 15 parts, Rhizoma Et Radix Notopterygii 15 parts, Radix Clematidis 15 parts,
Cortex Moutan 15 parts, Rhizoma Chuanxiong 15 parts, Semen Cuscutae 15 parts, Radix Achyranthis Bidentatae 10 parts, Herba Schizonepetae 10 parts.
Pharmaceutical composition its preparation method of the present invention is:
(1) for subsequent use according to weight weighting raw materials
(2) get Herba Taraxaci, Myrrha, Semen Nelumbinis, Rhizoma Sparganii, Cortex Moutan difference powder routinely, 100 mesh sieves that sieve are stand-by, then by medicated powder mix homogeneously, prepare complex A;
(3) get Radix Angelicae Sinensis, Folium Perillae, Poria, Ramulus Cinnamomi, Fructus Hordei Germinatus, Herba Cistanches, Semen Strychni, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Schizonepetae decoct with water; first time adds 4 times of weight water; decoct 2 hours; obtain filtrate and medicinal residues after filtration, medicinal residues are added 2 times of weight water and decoct 1 hour, after filtration, obtain filtrate; merge twice filtrate; filtrate after merging is condensed into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverizes and obtain complex B;
(4) get the ethanol that surplus stock adds 3 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverizes and obtains complex C;
(5) Homogeneous phase mixing complex A, B, C, in incapsulating, sterilization obtains capsule product, each oral 0.3g, three times on the one.
A course for the treatment of two Mondays, take 2-3 the course for the treatment of continuously.
Embodiment 2:
A kind of for soft tissue injury, the pharmaceutical composition of fracture, is characterized in that it is prepared by the raw material of following weight proportioning:
Radix Angelicae Sinensis 40 parts, Folium Perillae 40 parts, Herba Taraxaci 40 parts, Myrrha 40 parts, Radix Paeoniae Rubra 40 parts,
35 parts, Semen Nelumbinis, Radix Notoginseng 35 parts, Rhizoma Zingiberis 35 parts, Flos Lonicerae 35 parts, Cortex Magnoliae Officinalis 35 parts,
30 parts, Radix Rubiae, 30 parts, Poria, Ramulus Cinnamomi 30 parts, 30 parts, Fructus Hordei Germinatus, Herba Cistanches 30 parts,
28 parts, Radix Rehmanniae Preparata, Fructus Psoraleae 28 parts, Rhizoma Sparganii 25 parts, Rhizoma Cyperi 25 parts, 25 parts, Flos Carthami,
Herba speranskiae tuberculatae 25 parts, Semen Strychni 20 parts, Radix Saposhnikoviae 20 parts, Rhizoma Et Radix Notopterygii 20 parts, Radix Clematidis 20 parts,
Cortex Moutan 18 parts, Rhizoma Chuanxiong 18 parts, Semen Cuscutae 18 parts, Radix Achyranthis Bidentatae 15 parts, Herba Schizonepetae 15 parts.
Pharmaceutical composition its preparation method of the present invention is:
(1) for subsequent use according to weight weighting raw materials
(2) get Herba Taraxaci, Myrrha, Semen Nelumbinis, Rhizoma Sparganii, Cortex Moutan difference powder routinely, 100 mesh sieves that sieve are stand-by, then by medicated powder mix homogeneously, prepare complex A;
(3) get Radix Angelicae Sinensis, Folium Perillae, Poria, Ramulus Cinnamomi, Fructus Hordei Germinatus, Herba Cistanches, Semen Strychni, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Schizonepetae decoct with water; first time adds 4 times of weight water; decoct 2 hours; obtain filtrate and medicinal residues after filtration, medicinal residues are added 2 times of weight water and decoct 1 hour, after filtration, obtain filtrate; merge twice filtrate; filtrate after merging is condensed into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverizes and obtain complex B;
(4) get the ethanol that surplus stock adds 3 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverizes and obtains complex C;
(5) Homogeneous phase mixing complex A, B, C, in incapsulating, sterilization obtains capsule product, each oral 0.3g, three times on the one.
A course for the treatment of two Mondays, take 2-3 the course for the treatment of continuously.
Embodiment 3
Clinical data
From admission fractures case in recent years, select 129 examples, be divided into treatment group and matched group at random, in two groups of cases selected, medical history, the state of an illness, age, sex are as far as possible quite, and are hospitalization.Treatment group 64 example, age 25-50 year, 37 years old mean age.Wherein fracture 40 example, soft tissue injury 24 example.Matched group 65 example, age 26-52 year, 39 years old mean age, wherein fracture 43 example, soft tissue injury 22 example.
Treatment group, except conventional therapy, takes pharmaceutical preparation prepared by the embodiment of the present invention 2, a course for the treatment of two Mondays.Matched group adopts conventional therapy, within two weeks, is a course for the treatment of, observes therapeutic effect at any time, affected part swelling regression time, within every 7 days, take the photograph sheet once, checks para-position and growth of spur situation and suffering limb functional rehabilitation time.
Criterion of therapeutical effect: be divided into healing, improvement, invalid three grades.
Curative effect of fracture criterion, cure: fracture satisfied to line para-position, have seriality callus formation, the broken ends of fractured bone is without tenderness, and nothing impacts pain, functional rehabilitation.Take a turn for the better: para-position and to line still can, or fracture reduction is not good, but functional rehabilitation is fair.Invalid: nonunion synthesis local obviously deformity, dysfunction.
Soft tissue injury curative effect judging standard: cure: pain, swelling, ecchymosis disappear, and functional rehabilitation is normal.Take a turn for the better: pain, swelling disappear, and function is obviously improved, but affected part still has discomfort.Invalid: symptom, function sign are all without improvement.
Therapeutic outcome:
Simple soft tissue falls, beat, sprain from medication to functional rehabilitation be administration time.Average administration time is one week, subsides a swelling completely, without pain.Matched group is effective needs 2-4 week, and treatment group than matched group time advance 2-4 doubly.Two groups of therapeutic outcomes (P<0.01) as shown in table 1 below:
Table 1
Group Example time Cure Take a turn for the better Invalid Total effective rate
Embodiment 2 groups 64 49 13 2 96.8％
Matched group 65 34 21 10 84.6％
Two groups have significant difference.
Embodiment 4
Model case:
Cao 31 years old, because waist is injured, left side pain, through medical treatment, apply with medical herbs, lumbago took a turn for the better to some extent at that time, and when sending out during midway only, lumbago of raining, bid in plaster is from pasting to no effect.Most immediate cause is sprained, and lumbago is inactive, left side pain severe.The hospital of traditional Chinese hospital is gone to do acupuncture, massage repeatedly, poor effect.Present seat, all pains of bending over, also pain is stood up in sleep, and activity is obstructed.Admission examination: lumbar vertebra 3/4 presses pain, lumbar vertebra both sides soft tissue rope strip and lump, be diagnosed as waist old injury and waist soft tissue sprain, takes pharmaceutical composition prepared by embodiment 2, every day 3 times.Check pain after the course for the treatment of substantially to disappear, freely, advise and continue to take one week, patient main suit recovers completely in activity, and through above-mentioned treatment two weeks, transference cure, frequentation was not recurred so far.
Above-mentioned each Chinese medicine that the present invention adopts makes compatibility mutually, its collaborative effect of curing the disease can be played, there is between each composition of raw material of Chinese medicine used drug effect be interweaved and mutually promote and coordinate usefulness, through clinical verification, be applicable to Whole Body each position closed fracture and each position comminuted fracture, can relaxing muscles and tendons and activating QI and blood in the collateral, promoting tissue regeneration by removing blood stasis, hemostasis and pain-relieving, the application's pharmaceutical composition is with low cost, evident in efficacy, have broad application prospects.

Claims (4)

1. for a pharmaceutical composition for soft tissue injury, fracture, it is characterized in that, described pharmaceutical composition is prepared from by following raw material medicaments:
Radix Angelicae Sinensis, Folium Perillae, Herba Taraxaci, Myrrha, Radix Paeoniae Rubra, Semen Nelumbinis, Radix Notoginseng, Rhizoma Zingiberis, Flos Lonicerae, Cortex Magnoliae Officinalis, Radix Rubiae, Poria, Ramulus Cinnamomi, Fructus Hordei Germinatus, Herba Cistanches, Radix Rehmanniae Preparata, Fructus Psoraleae, Rhizoma Sparganii, Rhizoma Cyperi, Flos Carthami, Herba speranskiae tuberculatae, Semen Strychni, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Clematidis, Cortex Moutan, Rhizoma Chuanxiong, Semen Cuscutae, Radix Achyranthis Bidentatae, Herba Schizonepetae.
2. pharmaceutical composition according to claim 1, is characterized in that, described pharmaceutical composition is prepared by the raw material of following weight proportioning:
Radix Angelicae Sinensis 40 parts, Folium Perillae 40 parts, Herba Taraxaci 40 parts, Myrrha 40 parts, Radix Paeoniae Rubra 40 parts,
35 parts, Semen Nelumbinis, Radix Notoginseng 35 parts, Rhizoma Zingiberis 35 parts, Flos Lonicerae 35 parts, Cortex Magnoliae Officinalis 35 parts,
30 parts, Radix Rubiae, 30 parts, Poria, Ramulus Cinnamomi 30 parts, 30 parts, Fructus Hordei Germinatus, Herba Cistanches 30 parts,
28 parts, Radix Rehmanniae Preparata, Fructus Psoraleae 28 parts, Rhizoma Sparganii 25 parts, Rhizoma Cyperi 25 parts, 25 parts, Flos Carthami,
Herba speranskiae tuberculatae 25 parts, Semen Strychni 20 parts, Radix Saposhnikoviae 20 parts, Rhizoma Et Radix Notopterygii 20 parts, Radix Clematidis 20 parts,
Cortex Moutan 18 parts, Rhizoma Chuanxiong 18 parts, Semen Cuscutae 18 parts, Radix Achyranthis Bidentatae 15 parts, Herba Schizonepetae 15 parts.
3. the pharmaceutical composition according to claim 1-2, is characterized in that, the preparation method of described pharmaceutical composition comprises the steps:
(1) each raw material for standby is taken according to weight proportion;
(2) get Herba Taraxaci, Myrrha, Semen Nelumbinis, Rhizoma Sparganii, Cortex Moutan, pulverize and sieve, mix homogeneously, prepare complex A;
(3) get Radix Angelicae Sinensis, Folium Perillae, Poria, Ramulus Cinnamomi, Fructus Hordei Germinatus, Herba Cistanches, Semen Strychni, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Herba Schizonepetae, mixing, decocts with water, and adds the water of 4 times of weight for the first time, decocts 2 hours, obtain filtrate and medicinal residues after filtration; Second time adds the water of 2 times of weight in medicinal residues, decocts 1 hour, obtains filtrate, merge twice filtrate after filtration, and the filtrate after merging is condensed into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverizes and obtains complex B;
(4) get surplus stock, mixing, add the ethanol of 3 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the extractum that density is 1.2g/ml, after 60 DEG C of dryings, pulverizes and obtains complex C;
(5) Homogeneous phase mixing complex A, complex B and complex C and get final product.
4. the purposes of pharmaceutical composition described in claim 1-3.
CN201510935366.2A 2015-12-15 2015-12-15 Drug composition for soft tissue injury and fracture Pending CN105343862A (en)

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