CN103550446B - Traditional Chinese medicine composition for external use to treat rheumatoid arthritis and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for external use to treat rheumatoid arthritis and application of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for external use to treat rheumatoid arthritis, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for the external use to treat the rheumatoid arthritis is prepared from the following Chinese herbal medicines in parts by weight: 30-50 parts of tangerine leaf, 30-50 parts of garden balsam stem, 15-22 parts of rhizoma acori graminei, 6-10 parts of euphorbia pekinensis, 40-80 parts of ramulus mori and 40-80 parts of willow branch. The traditional Chinese medicine composition for the external use to treat the rheumatoid arthritis, which is disclosed by the invention, has the effects of expelling wind, clearing away cold, eliminating dampness, dredging channels, activating blood to promote menstruation, and promoting qi circulation to relieve pain, and has a remarkable curative effect of treating the rheumatoid arthritis.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and application thereof of external curing rheumatoid arthritis, particularly relate to a kind of Chinese medicine composition of fumigation treatment rheumatoid arthritis, belong to technical field of Chinese medicines.
Background technology
Rheumatoid arthritis (RA) is a kind of autoimmune disease being main clinical manifestation with chronic, symmetry, polyarthritis.Have saying of " not dead cancer ", its prevalence is about 0.3% ~ O.4%.Become the great killer of people's free living.The mechanism of current western medical treatment rheumatoid arthritis is mainly eased pain, antiinflammatory, antipyretic etc., but, use Western medicine usually can not stop PD, can not realize curing, more seriously, its side effect is quite large, and as gastrointestinal untoward reaction, adrenal cortex underactivity, osteoporosis, aseptic osteonecrosis etc., these toxic and side effects are even even more serious than rheumatoid arthritis itself.
Motherland's medical science is referred to as arthromyodynia." Plain Questions numbness opinion " day: " wet three gas of wind and cold are mixed extremely, and combined into numbness, therefore, ailment said due to cold or exposure, damp, cold-evil are pathogenic direct factors, and wind makes the injury of tendon and muscle, wet and cause BI-syndrome located in muscle, meridians impatency, cause QI-blood circulation smooth and fall ill.Rheumatoid Arthritis with Traditional Chinese Medicine has a long history, all on the books in many classical documents, and herbal fumigation is the combined effect of borrowing heating power and medicine to control, and by skin expansion tiny blood vessels, accelerates blood circulation, from outward appearance to inner essence, in warm middle enforcement treatment.And the skin organ that to be human body maximum, there is the several functions such as secretion, absorption, infiltration, excretion, sensation.Herbal fumigation is exactly the physiological property utilizing skin, and medicine is absorbed by skin surface, enters blood circulation thus reaches the effect for the treatment of.
Summary of the invention
The object of the invention is to by prescription again after studying Chinese medicine pharmacology, provide a kind of short treating period, determined curative effect, the Chinese medicine composition for the treatment of rheumatoid arthritis had no side effect and medical usage.
The object of the present invention is achieved like this:
The Chinese medicine composition of a kind of external curing rheumatoid arthritis of the present invention, described compositions is prepared from by the Chinese crude drug of following weight proportion: Folium Citri tangerinae 30-50 part, Herba speranskiae tuberculatae 30-50 part, Rhizoma Acori Graminei 15-22 part, Radix Euphorbiae Pekinensis 6-10 part, Ramulus Mori 40-80 part, Ramulus Salicis Babylonicae 40-80 part.
Preferably, the Chinese medicine composition of above-mentioned external curing rheumatoid arthritis, wherein said compositions is prepared from by the Chinese crude drug of following weight proportion: Folium Citri tangerinae 36-42 part, Herba speranskiae tuberculatae 36-42 part, Rhizoma Acori Graminei 18-20 part, Radix Euphorbiae Pekinensis 6-8 part, Ramulus Mori 50-70 part, Ramulus Salicis Babylonicae 50-70 part.
In the present invention's most preferred embodiment, the Chinese medicine composition of described external curing rheumatoid arthritis is prepared from by the Chinese crude drug of following weight proportion: Folium Citri tangerinae 38 parts, Herba speranskiae tuberculatae 38 parts, Rhizoma Acori Graminei 18 parts, 8 parts, the Radix Euphorbiae Pekinensis, Ramulus Mori 60 parts, Ramulus Salicis Babylonicae 60 parts.
Further preferably, the Chinese medicine composition of above-mentioned external curing rheumatoid arthritis is powder.
Found by experimental study, the pharmaceutical composition be made up of the Chinese crude drug of said ratio coordinates the evident in efficacy of western medicine rheumatoid arthritis.Therefore, second object of the present invention is to provide a kind of new medical use, the application of namely above-mentioned Chinese medicine composition in the medicine of preparation treatment rheumatoid arthritis.
According to Chinese medicine Historical Data Data About, the present invention's Chinese crude drug used has following pharmacologically active and function cures mainly:
Folium Citri tangerinae: soothing the liver, circulation of qi promoting, reduces phlegm, detumescence poison.Control hypochondriac pain, acute mastitis, lung abscess, cough, chest and diaphragm feeling of fullness, hernia.Select the leaf of the multiple Fructus Citri tangerinae class such as leaf or Zhu's Fructus Citri tangerinae of rutaceae orange Citrus reticulata Blanco.
Herba speranskiae tuberculatae: wind-damp dispelling, invigorates blood circulation, relaxing muscles and tendons, pain relieving.Dispelling the wind and dampness pathogens pain, sprain and contusion are hindered, innominate toxic swelling, eczema scrotum.Be selected from the young stem and leaf of leguminous plant Herba Viciae Amoenae.
Rhizoma Acori Graminei: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.Derive from the rhizome of acorus gramineus araceae plant.
The Radix Euphorbiae Pekinensis: the effect with diuretic, detumescence; Cure mainly edema distension, phlegm retention gathered, carbuncle furunculosis.Select the root of Maguireothamnus speciosus Knoxia valerianoides or euphorbia plant Radix Euphorbiae Pekinensis.
Ramulus Mori: wind-damp dispelling, sharp joint, row aqueous vapor.Control anemofrigid-damp arthralgia, spasm of the limbs, beriberi edema, human body pruritus due to wind pathogen.Select the dry twig of moraceae plants Mulberry Morus alba L..
Ramulus Salicis Babylonicae: dispel the wind, diuresis, pain relieving, detumescence.Dispelling the wind and dampness pathogens arthralgia pain, gonorrhea, nebulousurine, urinary obstruction, infectious hepatitis, swelling due to wind, furuncle, erysipelas, dental caries, swelling of the gum.Select the dry branch of Salicaceous Plants Salix babylonica L..
Chinese medicine composition of the present invention has expelling wind and cold, eliminating dampness and dredging channels, promoting blood circulation to restore menstrual flow, the effect of promoting the circulation of QI to relieve pain, and short treating period, determined curative effect, have no side effect, simple and practical feature, patient is acceptant.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
embodiment 1
Crude drug prescription:
Folium Citri tangerinae 380 grams, Herba speranskiae tuberculatae 380 grams, Rhizoma Acori Graminei 180 grams, 80 grams, the Radix Euphorbiae Pekinensis, Ramulus Mori 600 grams, Ramulus Salicis Babylonicae 600 grams.
Preparation method:
Get above-mentioned Chinese crude drug, clean roguing, dry, be ground into granule, pulverization, by every bag of 200 grams of subpackages.
embodiment 2
Crude drug prescription:
Folium Citri tangerinae 450 grams, Herba speranskiae tuberculatae 300 grams, Rhizoma Acori Graminei 180 grams, 100 grams, the Radix Euphorbiae Pekinensis, Ramulus Mori 500 grams, Ramulus Salicis Babylonicae 660 grams.
Preparation method:
Get above-mentioned Chinese crude drug, clean roguing, dry, be ground into granule, pulverization, by every bag of 200 grams of subpackages.
embodiment 3
Crude drug prescription:
Folium Citri tangerinae 500 grams, Herba speranskiae tuberculatae 500 grams, Rhizoma Acori Graminei 220 grams, 80 grams, the Radix Euphorbiae Pekinensis, Ramulus Mori 650 grams, Ramulus Salicis Babylonicae 540 grams.
Preparation method:
Get above-mentioned Chinese crude drug, clean roguing, dry, be ground into granule, pulverization, by every bag of 200 grams of subpackages.
embodiment 4
Crude drug prescription:
Folium Citri tangerinae 430 grams, Herba speranskiae tuberculatae 320 grams, Rhizoma Acori Graminei 200 grams, 60 grams, the Radix Euphorbiae Pekinensis, Ramulus Mori 700 grams, Ramulus Salicis Babylonicae 800 grams.
Preparation method:
Get above-mentioned Chinese crude drug, clean roguing, dry, be ground into granule, pulverization, by every bag of 200 grams of subpackages.
Herbal fumigation is to the effectiveness study of rheumatoid arthritis patients
Rheumatoid arthritis is made a definite diagnosis: (1) deadlock in morning is 1h (>=6 weeks) at least by following diagnostic criteria; (2) 2 or more than 3 arthroncuss (>=6 weeks); (3) wrist, the palm refer to, proximal interphalangeal joint swelling (>=6 weeks); (4) symmetry arthroncus (>=6 weeks); (5) rheumatoid subcutaneous nodule; (6) hands x-ray image changes (having osteoporosis and articular cavity narrow gaps at least); (7) rheumatoid factor positive (titre >l:32).4 diagnosable rheumatoid arthritiss of the positive are had in above 7.
Make a definite diagnosis by above-mentioned standard rheumatoid arthritis patients 56 example: 23 ~ 60 years old age, the mean age (46.2 ± 12.3) year; The course of disease 3 ~ 28 years, average course of disease (8.0 ± 5.9) year.All patients are divided into two groups at random: stifling group 28 example, man 9 example, female 19 example; Matched group 28 example, man 10 example, female 18 example; Two groups of Genders, age, the course of disease through statistical procedures, no significant difference (P>0.O5).
Matched group is treated as follows: meloxicam tablet 7.5mg/d, in methotrexate 7.5mg/ week, does not add other drug, other treatment.Treat as follows for stifling group: on treatment of control group basis, coordinate Chinese medicine composition fumigation treatment of the present invention.Fumigating method: get Chinese powder medicine 1 bag prepared by the embodiment of the present invention 1, soak 1h by proper amount of clear water, put in people's fumigate therapeutic apparatus (medicinal intelligent therapeutic instrument JS-809B) and boil, temperature is generally arranged on 40-50 DEG C.Fumigate the extremities joint of patient or whole body, for movable inconvenient joint, soak pathological changes joint after available towel adhesional wetting medicinal liquid, 1 time/d, 1 bag medicine uses 2d, and stifling 30min, 20d are 1 course for the treatment of at every turn, evaluate curative effect after treating 2 courses for the treatment of.
Efficacy assessment standard is divided into three grades: effective: symptomatology is eliminated or cardinal symptom is eliminated, and function of joint is recovered substantially, and can participate in normal work or physical labor, laboratory checking index is normal; Effective: cardinal symptom is eliminated substantially, major joint function is recovered or obviously progress substantially, and can't take care of oneself to transfer to can take care of oneself, or lose the job and work capacity transfer to work and ability to work recover to some extent, laboratory checking index makes moderate progress; Invalid: to compare with before treatment, each side is all without progressive.
Two groups of Clinical efficacy comparisons are in table 1.Can be found out by table 1, after treatment, total effective rate fumigates group is 96.4%, and matched group is 57.1%, and the obvious effective rate of stifling group treatment rheumatoid arthritis is obviously better than matched group.In addition, compared with matched group, stifling group can significantly be improved the symptom and sign such as arthralgia, dysfunction.
Table 1 liang group patient comparitive study
Claims (5)
1. a Chinese medicine composition for external curing rheumatoid arthritis, is characterized in that: described compositions is prepared from by the Chinese crude drug of following weight proportion: Folium Citri tangerinae 30-50 part, Herba speranskiae tuberculatae 30-50 part, Rhizoma Acori Graminei 15-22 part, Radix Euphorbiae Pekinensis 6-10 part, Ramulus Mori 40-80 part, Ramulus Salicis Babylonicae 40-80 part.
2. the Chinese medicine composition of external curing rheumatoid arthritis according to claim 1, is characterized in that: described compositions is prepared from by the Chinese crude drug of following weight proportion: Folium Citri tangerinae 36-42 part, Herba speranskiae tuberculatae 36-42 part, Rhizoma Acori Graminei 18-20 part, Radix Euphorbiae Pekinensis 6-8 part, Ramulus Mori 50-70 part, Ramulus Salicis Babylonicae 50-70 part.
3. the Chinese medicine composition of external curing rheumatoid arthritis according to claim 2, is characterized in that: described compositions is prepared from by the Chinese crude drug of following weight proportion: Folium Citri tangerinae 38 parts, Herba speranskiae tuberculatae 38 parts, Rhizoma Acori Graminei 18 parts, 8 parts, the Radix Euphorbiae Pekinensis, Ramulus Mori 60 parts, Ramulus Salicis Babylonicae 60 parts.
4. the Chinese medicine composition of the external curing rheumatoid arthritis according to claim 1 or 2 or 3, is characterized in that: described compositions is powder.
5. the application of the Chinese medicine composition of claim 1 or the external curing rheumatoid arthritis described in 2 or 3 in the medicine of preparation treatment rheumatoid arthritis.
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| CN109350658A (en) * | 2018-12-14 | 2019-02-19 | 北京蜂珍科技开发有限公司 | A kind of bee venom Chinese medicine scraping oil for rheumatic arthritis |
| CN109364166A (en) * | 2018-12-14 | 2019-02-22 | 北京蜂珍科技开发有限公司 | A kind of water-soluble scraping agent containing bee venom |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101164604A (en) * | 2007-06-11 | 2008-04-23 | 徐发成 | Traditional Chinese medicine for treating arthrosis and preparing method thereof |
| CN101862421A (en) * | 2010-06-09 | 2010-10-20 | 杨青 | Chinese medicinal ointment composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101164604A (en) * | 2007-06-11 | 2008-04-23 | 徐发成 | Traditional Chinese medicine for treating arthrosis and preparing method thereof |
| CN101862421A (en) * | 2010-06-09 | 2010-10-20 | 杨青 | Chinese medicinal ointment composition |
Non-Patent Citations (1)
| Title |
|---|
| 中医外治类风湿性关节炎近况;吕军影;《黑龙江中医药》;19970430(第4期);第54-57页 * |
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