CN102028872B - Orally-taken traditional Chinese medicine for treating acute lumbar muscle sprain and preparation method thereof - Google Patents
Orally-taken traditional Chinese medicine for treating acute lumbar muscle sprain and preparation method thereof Download PDFInfo
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- 239000011800 void material Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- WFDGBBHAJUVQKE-UHFFFAOYSA-N ziyu-glycoside II Natural products CC1(O)CCCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OCC(O)C(O)C6O)C(C)(C)C5CCC34C)C12)C(=O)O WFDGBBHAJUVQKE-UHFFFAOYSA-N 0.000 description 1
- NHWWFKVFYNAGJV-UHFFFAOYSA-N ziyuglycoside I Natural products CC1(O)CCCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OCC(O)C(O)C6O)C(C)(C)C5CCC34C)C12)C(=O)OC7OC(CO)C(O)C(O)C7O NHWWFKVFYNAGJV-UHFFFAOYSA-N 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides an orally-taken traditional Chinese medicine for treating acute lumbar muscle sprain. The orally-taken traditional Chinese medicine is characterized by comprising the following raw materials in percentage by mass: 8-40 percent of asiatic toddalia root, 7-30 percent of arisaema zanthoxylum, 7-30 percent of ceylon houndstongue leaf or root-bark, 5-20 percent of sargentg loryvine, 5-20 percent of kadsura interior, 5-20 percent of garden burnet root, 5-20 percent of epimedium, 2-10 percent of Chinese pholidota and 2-10 percent of psoralea corylifolia. The orally-taken medicine in dosage forms of electuary, granules, tablets, capsules, pills, syrup and like can be prepared by using a conventional preparation method according to the following steps of: directly crushing the medicines into medicine powder, or carrying out impregnating with various solvents, infiltrating, decocting, reflowing, ultrasonic treatment and CO2 critical (subcritical) extraction to extract effective components in the medicine and adding a proper amount of medicinal auxiliary material. The prepared method is scientific, simple and convenient, retains more effective components, requires simple equipment and has short production time and no pollution. The prepared medicine is the orally-taken medicine and plays the effect on the whole body after being absorbed by gastrointestinal tract; various medicines are synthesized to play roles of promoting blood circulation to remove blood stasis, regulating qi and smoothing the veins, reducing swelling and alleviating pain and nourishing the liver and the kidney, thereby eradicating pains of waist injury, fading away the swelling and purplish spots of the waist part and restoring the function activities.
Description
Technical field
The present invention relates to a kind of Chinese medicine for oral administration of treating acute lumbar muscle sprain and preparation method thereof, belong to biological pharmacy technical field.
Background technology
It is sick and wounded that acute lumbar muscle sprain belongs to acute soft tissue; Be muscle, fascia, ligament, little joint and the isostructural acute injury of synovial membrane, but as damage serious pressuring nerve tip and cause muscle spasm owing to prominent waist sacrum, sacrum ilium and the lumbar vertebra both sides that receive violence or undue force to cause the excessive tractive of waist muscle fascia tissue to cause.Acute lumbar muscle sprain can cause flank pain and cause the movable function obstacle, and patient often waist activity is seriously limited, can not reverse and lateral bending, and patient Duo Yin is painful, stiff and panic, clinical comparatively common.
Acute lumbar muscle sprain clinically more adopts physiotherapy and antipyretic-antalgic anti-inflammatory agent thing to carry out expectant treatment.Sprain the external application of available cold water towel in early days, use the pain relieving of antipyretic-antalgic anti-inflammatory agent thing, but unsuitable hot compress and massage.Sprain the later stage and then must go functional exercise, massage, acupuncture, electrotherapy etc., be equipped with the for oral administration or external application of medicine and treat.The flat bed of also should sleeping after spraining loosens psoas muscle and ligament.
The traditional Chinese medical science thinks that acute lumbar muscle sprain belongs to the muscle and tendon injury category, " element ask thorn lumbago opinion " cloud " waist is hindered in weight lifting, and stagnant blood is returned it ", and external force acts on waist, causes that passages through which vital energy circulates is impaired, the mechanism of qi operation is smooth, qi depression to blood stasis.QI-blood circulation is smooth, water wets internal resistance, the wet knot mutually of blood stasis water, so cause numb pain.So muscle main motion, the injury of tendon and muscle owner of lost property that then moves is limitation of activity.Therefore the tcm treatment method of primary disease is to want with promoting flow of QI and blood, mediation muscle arteries and veins.In addition, it also is one of inducement of primary disease that deficiency of kidney-QI, kidney yang are lost void, and it is auxilliary holding concurrently with the kidney invigorating medicine.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine for oral administration of treating acute lumbar muscle sprain; Select for use have promoting flow of QI and blood, the Chinese crude drug of effect such as stasis-dispelling and pain-killing, collateral dredging detumescence, diuretic dehumidifying, nourishing the liver and kidney carries out reasonable formula; Be mixed with Chinese medicine preparation for oral administration, through bringing into play general action after the gastrointestinal absorption.All medicines share, and have the effect of blood circulation promoting and blood stasis dispelling, regulating qi and dredging collateral, reducing swelling and alleviating pain, thereby accelerate the therapeutic process of lumbar injury, eradicate pain, and waist swelling, ecchymosis are disappeared, and pain disappears, and functional activity recovers.
Another object of the present invention is to provide a kind of method for preparing of treating the Chinese medicine for oral administration of acute lumbar muscle sprain.
The present invention accomplishes through following technical proposal: a kind of Chinese medicine for oral administration of treating acute lumbar muscle sprain is characterized in that being made up of following raw materials by weight percentage:
Radix Toddaliae Asiaticae 8-40%
Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils 7-30%
Cortex cynoglossi zeylanici radicis 7-30%
Caulis Sargentodoxae 5-20%
Kadsura interior 5-20%
Radix Sanguisorbae 5-20%
Herba Epimedii 5-20%
Pseudobulbus Pholidotae Chinensis 2-10%
Fructus Psoraleae 2-10%
The Chinese medicine for oral administration of said treatment acute lumbar muscle sprain, preferred following raw materials by weight percentage combination, curative effect is better:
Radix Toddaliae Asiaticae 20%
Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils 15%
Cortex cynoglossi zeylanici radicis 15%
Caulis Sargentodoxae 10%
Kadsura interior 10%
Radix Sanguisorbae 10%
Herba Epimedii 10%
Pseudobulbus Pholidotae Chinensis 5%
Fructus Psoraleae 5%
Wherein, Radix Toddaliae Asiaticae is root or the root bark of rutaceae Radix Toddaliae Asiaticae (Toddalia asiatica (L.) Lam.).Acrid in the mouth, hardship, slightly warm in nature.Contain alkaloid, coumarin, volatile oil, resin etc.Effect: dissipating blood stasis hemostasis, expelling wind and removing dampness, subduing swelling and detoxicating.Dispelling the wind and dampness pathogens pain, stomachache, traumatic injury, haematemesis, epistaxis, sub-official is hemorrhage, knife injury is hemorrhage, amenorrhea, dysmenorrhea, intercostal neuralgia, furuncle toxic swelling.
Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils is root or the root bark of rutaceae Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils (Zanthoxylum dimorphophyllum Hemsl.Var.spinifoliumRehd.et Wils.).The property hot, puckery, flavor is flat.Go into liver, lung meridian.Contain alkaloid in the rhizome.Effect: expelling wind and cold, relaxing muscles and tendons to promote blood circulation, analgesia.Control the cough due to wind and cold, rheumatic numbness, traumatic injury, traumatic hemorrhage, constipation.
Cortex cynoglossi zeylanici radicis is root, ratan, the leaf of Schisandraceae plant Cortex cynoglossi zeylanici radicis (Schisandra propinqua (Wall.) Baill.var.Sinensis Oliv.).Sweet in the mouth acid, warm in nature.Contain different trimethyl gallic acid, deoxyschisandrin, stearic acid etc. in root and the stem.Effect: promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis.Control traumatic injury, rheumatic numbness, bones and muscles pain, consumptive disease and hinder haematemesis, amenorrhea, abdominal distention, carbuncle.
Caulis Sargentodoxae is the dry rattan of Lardizabalaceae plant Caulis Sargentodoxae (Sargentodoxa cuneata (oliv.) Rehd.et wils.).The property bitter, flat.Return large intestine, Liver Channel.Have that heat-clearing and toxic substances removing is invigorated blood circulation, the effect of wind-expelling pain-stopping.Contain emodin, physcione, chrysophanol, Caulis Sargentodoxae polysaccharide etc.These article extract has bacteriostasis, and can suppress thrombosis to antiplatelet aggregation.Be used for abdominalgia with intestinal abscess, pathopyretic ulcer, traumatic injury, amenorrhea dysmenorrhea, rheumatic arthralgia etc.
Kadsura interior has another name called Kadsura interior, is mainly derived from Schisandraceae Kadsura Kadsura interior (Kadsura interiorA.C.Smith) ratan.Warm in nature, bitter in the mouth, sweet.Return liver, kidney channel.Contain chemical constituents such as kadsurin, Kadsura interior element.Function: blood circulation promoting and enriching, menstruction regulating and pain relieving, channels sootheing and network vessel quickening.Be used for menoxenia, dysmenorrhea, paralysis and numbness, rheumatic arthralgia, deficient qi and blood.
Radix Sanguisorbae is the dry root of rosaceous plant Radix Sanguisorbae (Sanguisorba officinalis L.).Contain chemical constituents such as tannin, ziyu glycoside I, ziyu glycoside II, sangushsorbin B.Nature and flavor: picric acid, cold.Go into liver, large intestine channel.Effect: skin ulcer is held back in cooling blood for hemostasis, detoxifcation.Be used to have blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Herba Epimedii is the dry aerial parts of Berberidaceae plant Herba Epimedii (Epimedium brevicomum Maxim.), arrow leaf Herba Epimedii (E.sagittatum (Sieb.et Zucc.) Maxim.), pubescence Herba Epimedii (E.pubescens Maxim.), Epimedium wushanense (E.wushanense T.S.Ying) or Herba Epimedii (E.koreanum Nakai).Contain epimedium flavone glycoside, tannin, volatilization wet goods chemical substance.Nature and flavor: hot, sweet, temperature.Return liver, kidney channel.Effect: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Be used for that impotence and seminal emission, muscles and bones flaccidity are soft, rheumatic arthralgia, numbness contracture, climacteric hypertension.
Pseudobulbus Pholidotae Chinensis derives from the orchid family Pseudobulbus Pholidotae Chinensis platymiscium Pseudobulbus Pholidotae Chinensis (Pholidota Chinensis Lindl.), with all herbal medicine, is commonly called as Shi Shanglian, stone Fructus Canarii albi etc.Herb contains chemical constituents such as triterpene, alkaloid, phenols.The property sugariness cool, have the effect of yin nourishing, heat clearing away, dampness removing repercussive, be mainly used in analgesia, also can be used for cough, haematemesis, nocturnal emission etc.
Fructus Psoraleae is the mature fruit of legumes psoraleae (Psoralea corylifolia L.).Contain chemical constituents such as Coumarins, flavonoid and monoterpene phenols.Nature and flavor: bitter, hot, temperature.Return kidney, spleen channel.Effect: kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, helping inspiration to relieve asthma.Be used for impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness is suffered from a deficiency of the kidney and is done to breathe heavily, and has loose bowels just before dawn; The external curing vitiligo, alopecia areata.
Second purpose of the present invention realizes through following technical scheme: a kind of method for preparing of treating the Chinese medicine for oral administration of acute lumbar muscle sprain is characterized in that through following each processing step:
A, get material by following mass percent:
Flying dragon palm 8-40%
Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils 7-30%
Cortex cynoglossi zeylanici radicis 7-30%
Caulis Sargentodoxae 5-20%
Kadsura interior 5-20%
Radix Sanguisorbae 5-20%
Herba Epimedii 5-20%
Pseudobulbus Pholidotae Chinensis 2-10%
Fructus Psoraleae 2-10%
B, respectively above-mentioned medical material directly is broken into medicated powder, perhaps through dipping, diafiltration, decoction, backflow, ultrasonic Treatment, the CO of all kinds of solvents
2Critical (subcritical) extraction adds proper quantity of medicinal auxiliary material again to extract the effective ingredient in the medical material, uses the conventional formulation method, is prepared into the endo-medicine of the treatment acute lumbar muscle sprain of dosage forms such as soft extract, granule, tablet, capsule, pill, syrup.
The preferred following extraction processing method of the present invention:
(1) adds 4-12 times of water Radix Sanguisorbae, Pseudobulbus Pholidotae Chinensis were decocted 1-6 hour, filter; Filtering residue adds 4-12 times of decocting and boiled 1-6 hour, filters; Filtering residue adds 4-12 times of decocting again and boiled 1-6 hour, filters merging filtrate; Filtrating is condensed into extractum, subsequent use.
(2) in Radix Toddaliae Asiaticae, Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils, Cortex cynoglossi zeylanici radicis, Caulis Sargentodoxae, Kadsura interior, Herba Epimedii, benefit bone marrow, add the 60-90% alcoholic solution that 3-10 doubly measures,, filter in 60-80 ℃ of hot reflux 1-4 hour; The 60-90% alcoholic solution that filtering residue reuse 3-10 doubly measures extracted 1-4 hour in 60-80 ℃ of hot reflux, filtered merging filtrate; Decompression filtrate recycling ethanol, it is subsequent use to get extractum;
(3) with step (1), (2) gained extractum mix homogeneously, sugaring (honey) is tempered and is processed the soft extract of stiff semifluid shape; Perhaps
(4) with step (1), (2) gained extractum mix homogeneously, after the adding appropriate amount of auxiliary materials, obtain medicine-containing particle with wet granulation method, the reuse conventional method further is prepared into granule, tablet or capsule; Perhaps
(5) method systems such as step (1), (2) gained extractum utilization spray drying, vacuum drying, fluid bed drying are got dry extract, pulverize, mix homogeneously after the adding appropriate amount of auxiliary materials, makes medicine-containing particle with dry granulation method; The reuse conventional method further is prepared into granule, tablet or capsule; Perhaps
(6) step (1), (2) gained extractum are mixed, join in the drop pill substrate that has heated, do not stop stirring and make whole fusions, splash into while hot in the liquid coolant, be condensed into drop pill; Perhaps
(7) step (1), (2) gained extractum are mixed, add an amount of glycerol hydrotropy, add the simple syrup dissolving again, process syrup.
The Chinese medicine for oral administration of treatment acute lumbar muscle sprain provided by the invention, select for use have promoting flow of QI and blood, the Chinese crude drug of effect such as stasis-dispelling and pain-killing, collateral dredging detumescence, diuretic dehumidifying, nourishing the liver and kidney carries out reasonable formula.Can be prepared into dosage forms for oral administration such as soft extract, granule, tablet, capsule, pill, syrup as required, the method for preparing science is easy, and effective ingredient keeps many, and equipment needed thereby is simple, and the production time is short, and is pollution-free.Made endo-medicine, through bringing into play general action after the gastrointestinal absorption, all medicines are collaborative, play the effect of blood circulation promoting and blood stasis dispelling, regulating qi and dredging collateral, reducing swelling and alleviating pain, nourishing the liver and kidney, thereby eradicate pain of lumbar injury, and waist swelling, ecchymosis are disappeared, and functional activity is able to recover.
The specific embodiment
Embodiment 1
A, get material: Radix Toddaliae Asiaticae 20g, Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils 15g, Cortex cynoglossi zeylanici radicis 15g, Caulis Sargentodoxae 10g, Kadsura interior 10g, Radix Sanguisorbae 10g, Herba Epimedii 10g, Pseudobulbus Pholidotae Chinensis 5g, Fructus Psoraleae 5g by following prescription.
B, the following preparation technology of process:
(1) adds 10 times of water Radix Sanguisorbae, Pseudobulbus Pholidotae Chinensis were decocted 4 hours, filter; Filtering residue adds 8 times of decoctings and boiled 3 hours, filters; Filtering residue adds 6 times of decoctings again and boiled 2 hours, filters merging filtrate; Filtrating is condensed into extractum, subsequent use.
(2) 75% alcoholic solution of 6 times of amounts of adding in Radix Toddaliae Asiaticae, Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils, Cortex cynoglossi zeylanici radicis, Caulis Sargentodoxae, Kadsura interior, Herba Epimedii, benefit bone marrow in 75 ℃ of hot refluxs 2 hours, filters; 75% alcoholic solution of 5 times of amounts of filtering residue reuse extracted 1.5 hours in 75 ℃ of hot refluxs, filtered merging filtrate; Decompression filtrate recycling ethanol, it is subsequent use to get extractum;
(3), add that honey is tempered and the soft extract of processing stiff semifluid shape with step (1), (2) gained extractum mix homogeneously.
Embodiment 2
A, get material: Radix Toddaliae Asiaticae 30g, Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils 20g, Cortex cynoglossi zeylanici radicis 20g, Caulis Sargentodoxae 8g, Kadsura interior 8g, Radix Sanguisorbae 8g, Herba Epimedii 8g, Pseudobulbus Pholidotae Chinensis 8g, Fructus Psoraleae 8g by following prescription.
B, the following preparation technology of process:
(1) adds 8 times of water Radix Sanguisorbae, Pseudobulbus Pholidotae Chinensis were decocted 2 hours, filter; Filtering residue adds 8 times of decoctings and boiled 2 hours, filters; Filtering residue adds 8 times of decoctings again and boiled 2 hours, filters merging filtrate; Filtrating is condensed into extractum, subsequent use.
(2) 70% alcoholic solution of 8 times of amounts of adding in Radix Toddaliae Asiaticae, Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils, Cortex cynoglossi zeylanici radicis, Caulis Sargentodoxae, Kadsura interior, Herba Epimedii, benefit bone marrow in 80 ℃ of hot refluxs 3 hours, filters; 70% alcoholic solution of 6 times of amounts of filtering residue reuse extracted 2 hours in 80 ℃ of hot refluxs, filtered merging filtrate; Decompression filtrate recycling ethanol, it is subsequent use to get extractum;
(3) with step (1), (2) gained extractum mix homogeneously, after the adding appropriate amount of starch, wet granulation gets medicine-containing particle, gets granule after the dry packing; Tabletting is processed tablet after perhaps in medicine-containing particle, adding an amount of Pulvis Talci, magnesium stearate; Can also in medicine-containing particle, add an amount of Pulvis Talci, incapsulate and make capsule.
Embodiment 3
A, get material: Radix Toddaliae Asiaticae 15g, Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils 10g, Cortex cynoglossi zeylanici radicis 10g, Caulis Sargentodoxae 15g, Kadsura interior 15g, Radix Sanguisorbae 15g, Herba Epimedii 15g, Pseudobulbus Pholidotae Chinensis 3g, Fructus Psoraleae 3g by following prescription.
B, the following preparation technology of process:
(1) adds 7 times of water Radix Sanguisorbae, Pseudobulbus Pholidotae Chinensis were decocted 3 hours, filter; Filtering residue adds 6 times of decoctings and boiled 3 hours, filters; Filtering residue adds 5 times of decoctings again and boiled 3 hours, filters merging filtrate; Filtrating is condensed into extractum, subsequent use.
(2) 80% alcoholic solution of 5 times of amounts of adding in Radix Toddaliae Asiaticae, Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils, Cortex cynoglossi zeylanici radicis, Caulis Sargentodoxae, Kadsura interior, Herba Epimedii, benefit bone marrow in 70 ℃ of hot refluxs 4 hours, filters; 80% alcoholic solution of 5 times of amounts of filtering residue reuse extracted 4 hours in 70 ℃ of hot refluxs, filtered merging filtrate; Decompression filtrate recycling ethanol, it is subsequent use to get extractum;
(3) be heated to 90 ℃ to PEG; Again step (1), (2) gained extractum are joined wherein; Under heat-retaining condition, do not stop to stir and make whole mix homogeneously, splash into while hot in 10 ℃～15 ℃ the liquid Paraffin, to the greatest extent and wipe liquid Paraffin the drop pill drop that is shaped; Put drying in the Calx cylinder, promptly make drop pill.
Therapeutic effect
Case is included standard in: the patient amounts to 29 people, though acute lumbar muscle sprain is arranged in the 5d due to the obvious inducement or do not have obvious inducement and prominent sense acute backache, dysfunction.
Therapeutic Method: give the patient according to the embodiment of the invention 1 made soft extract and take, 1 dose of every day, divide and take for 3 times.7d is 1 course of treatment.
Criterion of therapeutical effect: after 1 course of treatment of taking medicine; Patient's lumbago degree is divided into following three grades: I level (no pain, function normal), II level (mild pain, function and activity of daily living mild limitation); III level (moderate or severe pain, function and daily life are obviously limited).The I level is regarded as curing, and I level and II level are regarded as effectively.
Therapeutic outcome: behind the 7d that takes medicine, the lumbago degree evaluation is 22 examples that have of I level, II level 7 examples, cure rate 75.9%, total effective rate 100%.
Model case:
Zhao, the women, 31 years old, ascend a height and sprain waist when getting thing, course of disease 1d, the readme flank pain is violent.Inspection: the left of spine lateral bending, the left side muscular tone, the pitching song is stretched, has been changed one's position and sits all sense difficulties, and the lateral bending pain is more left.Give the patient according to the embodiment of the invention 1 made soft extract and take, 1 dose of every day, divide and take for 3 times.The lumbago symptom obviously alleviates behind the 2d, and the depletion of YANG gonosome is levied, and feels uncomfortable when bending over slightly.The lumbago symptom disappears basically behind the 5d, and pick-up test is negative.Activity freely behind the 7d.
Look into certain, the male, 35 years old, sprain waist when playing tennis, course of disease 2h, the readme waist is persistence severe pain.Inspection: look painful, with hand steered waist, and the posture of partly bending over.Blood stasis, edema appear in local muscle, and damage location has obvious pressure pain point, dragging pain, and the protectiveness muscular spasm appears in Ipsilateral.Flank pain is violent, and limitation of activity can not be straight and upright, stand up, walk.Give the patient according to the embodiment of the invention 1 made soft extract and take, 1 dose of every day, divide and take for 3 times.Lumbago disappears behind the 7d, and is movable as usual, anteflexion 90 °, after stretch 30 °, rotate 30 °.
Claims (4)
1. Chinese medicine for oral administration of treating acute lumbar muscle sprain is characterized in that crude drug is formed and mass percent is:
2. the Chinese medicine for oral administration of treatment acute lumbar muscle sprain according to claim 1 is characterized in that the crude drug composition of said Chinese medicine by following mass percent:
3. the method for preparing of the Chinese medicine for oral administration of treatment treatment acute lumbar muscle sprain according to claim 1 is characterized in that through following method preparation:
A, get crude drug by following mass percent:
B, respectively above-mentioned medical material directly is broken into medicated powder, perhaps through dipping, diafiltration, decoction, backflow, ultrasonic Treatment, the subcritical CO of all kinds of solvents
2Extraction adds proper quantity of medicinal auxiliary material again to extract the effective ingredient in the medical material, uses the conventional formulation method, is prepared into the endo-medicine of the treatment acute lumbar muscle sprain of soft extract, granule, tablet, capsule, pill, syrup formulation.
4. the method for preparing of the Chinese medicine for oral administration of treatment acute lumbar muscle sprain according to claim 3 is characterized in that by following extraction processing method:
(1) adds 4-12 times of water Radix Sanguisorbae, Pseudobulbus Pholidotae Chinensis were decocted 1-6 hour, filter; Filtering residue adds 4-12 times of decocting and boiled 1-6 hour, filters; Filtering residue adds 4-12 times of decocting again and boiled 1-6 hour, filters merging filtrate; Filtrating is condensed into extractum, subsequent use;
(2) in Radix Toddaliae Asiaticae, Zanthoxylum Dimorphophyllum Hemsl. Var Spinifolium Rhed. Et Wils, Cortex cynoglossi zeylanici radicis, Caulis Sargentodoxae, Kadsura interior, Herba Epimedii, benefit bone marrow, add the 60-90% alcoholic solution that 3-10 doubly measures,, filter in 60-80 ℃ of hot reflux 1-4 hour; The 60-90% alcoholic solution that filtering residue reuse 3-10 doubly measures extracted 1-4 hour in 60-80 ℃ of hot reflux, filtered merging filtrate; Decompression filtrate recycling ethanol, it is subsequent use to get extractum;
(3) with step (1) (2) gained extractum mix homogeneously, sugaring/honey is tempered and is processed the soft extract of stiff semifluid shape; Perhaps
(4) with step (1), (2) gained extractum mix homogeneously, after the adding appropriate amount of auxiliary materials, obtain medicine-containing particle with wet granulation method, the reuse conventional method further is prepared into granule, tablet or capsule; Perhaps
(5) method systems such as step (1), (2) gained extractum utilization spray drying, vacuum drying, fluid bed drying are got dry extract, pulverize, mix homogeneously after the adding appropriate amount of auxiliary materials, makes medicine-containing particle with dry granulation method; The reuse conventional method further is prepared into granule, tablet or capsule; Perhaps
(6) step (1), (2) gained extractum are mixed, join in the drop pill substrate that has heated, do not stop stirring and make whole fusions, splash into while hot in the liquid coolant, be condensed into drop pill; Perhaps
(7) step (1), (2) gained extractum are mixed, add an amount of glycerol hydrotropy, add the simple syrup dissolving again, process syrup.
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| CN101085161A (en) * | 2006-06-09 | 2007-12-12 | 倪胤超 | Medicine for treating acute lumbar sprain and preparation method thereof |
| CN101357172A (en) * | 2007-07-31 | 2009-02-04 | 金昌辉 | External traditional Chinese medicine for treating hyperosteogeny, urgent lumbar sprain, joint bursitis |
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| CN101085161A (en) * | 2006-06-09 | 2007-12-12 | 倪胤超 | Medicine for treating acute lumbar sprain and preparation method thereof |
| CN101357172A (en) * | 2007-07-31 | 2009-02-04 | 金昌辉 | External traditional Chinese medicine for treating hyperosteogeny, urgent lumbar sprain, joint bursitis |
| CN101618111A (en) * | 2008-06-30 | 2010-01-06 | 张在文 | Medicated wine for treating acute lumbar muscle sprain |
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