CN104800610A - Traditional Chinese medicine preparation for treating Parkinson's disease and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for treating Parkinson's disease and preparation method thereof Download PDF

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CN104800610A
CN104800610A CN201510250138.1A CN201510250138A CN104800610A CN 104800610 A CN104800610 A CN 104800610A CN 201510250138 A CN201510250138 A CN 201510250138A CN 104800610 A CN104800610 A CN 104800610A
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宋思佳
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宋思佳
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Abstract

The invention discloses a traditional Chinese medicine preparation for treating Parkinson's disease. The traditional Chinese medicine preparation is prepared from gastrodia elata, antler glue, zaocys dhumnade, crude dragon bone, asparagus cochinchinensis, radix ophiopogonis, cornu cervi degelatinatum, pearl powder, amber, long-noded pit viper, turtle shell, tortoise plastron, radix paeoniae alba, antelope's horn powder, radix notoginseng powder, dogwood, schisandra chinensis, angelica sinensis, longan pulp, manis pentadactyla, root of red-rooted salvia, scorpions, garden balsam stem, lycopodium clavatum, caulis spatholobi, jujube and crude liquorice at a certain weight proportion. The traditional Chinese medicine preparation has the effects of calming liver wind, warming liver and kidney, expelling wind and relieving convulsion, tranquilizing and allaying excitement, relaxing muscles and tendons and removing obstructionfrom meridians, is capable of effectively relieving and restraining progression of the Parkinson's disease so as to treat the Parkinson's disease.

Description

One treats Parkinsonian Chinese medicine preparation and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to one and treat Parkinsonian Chinese medicine preparation.The invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Parkinson disease (Parkinson ' s disease, PD) have another name called Parkinsonism, be one of modal neurodegenerative diseases.Old people is common, and average age of onset is about 60 years old, and the young parkinson disease of less than 40 years old onset are more rare.The prevalence of China over-65s crowd PD is approximately 1.7%.Major part Parkinsonian is Sporadic cases, only has the patient less than 10% to have family history.The topmost pathological change of parkinson disease is that the degeneration of substantia nigra of midbrain dopamine (dopamine, DA) serotonergic neuron is dead, causes striatum DA level significance reduce and cause a disease therefrom.Cause the definite cause of disease of this pathological change still unclear at present, inherited genetic factors, environmental factors, age ageing, oxidative stress etc. all may participate in the degeneration death process of PD dopaminergic neuron.
People have carried out more careful observation to parkinson disease, find except trembling, still there is muscular rigidity, write and other symptom such as write less and less, but the muscle power of extremity is not impaired, the case insidious onset of 50%-80%, the inactive " twist with the fingers ball sample " of onset symptoms normally 4 ~ 8Hz of side hand trembles.Thisly to tremble when limbs are static the most remarkable, weaken when limbs executed activity, disappear in sleep; Nervous or tiredly can make to tremble to increase the weight of, usually tremble at both hands, both arms and both legs are the most serious, symptom occur sequencing be also hand the earliest, at the latest, trembling also can appear leg in lower jaw, tongue, forehead and eyelid, but sounding is unaffected, many patients only show stiff.Also there will be muscular rigidity in addition, slow movement, specific positions, pain, paraesthesia, the symptoms such as dysphagia.
Medically mainly adopt Western medicine to treat for parkinson disease at present, but can only control or mitigation symptoms, relieving the pain caused by diseases, delay advancing of disease, life-time service also can produce toxicity to the health of patient, and curative effect can be made to weaken.Chinese medicine is since ancient times with regard to a rarity of China, and Chinese medicine is good at more " preventive treatment of disease ", from the angle disease therapy of entirety, thus embodies the superiority of Chinese traditional treatment.
Summary of the invention
The object of the present invention is to provide one to treat Parkinsonian Chinese medicine preparation, it is obvious that this Chinese medicine preparation has curative effect for parkinson disease, has no side effect, and taking convenience is cheap, feature.Alleviate the misery of patient, for the household of patient and patient alleviates burden and economic pressures at heart.
Another object of the present invention is to provide the preparation method of the Parkinsonian Chinese medicine preparation of this treatment.
Inventor is in clinical treatment practice for many years, observe the misery that parkinson disease are being brought to patient, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of Parkinsonian Chinese medicine preparation repeatedly, the present invention selects Rhizoma Gastrodiae, Colla cornus cervi, Zaocys, Os Draconis, Radix Asparagi, Radix Ophiopogonis, Cornu Cervi Degelatinatum, Margarita powder, succinum, Agkistrodon, Carapax Trionycis, Carapax et Plastrum Testudinis, the Radix Paeoniae Alba, Cornu Saigae Tataricae powder, Radix Notoginseng powder, Fructus Corni, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, Arillus Longan, Squama Manis, Radix Salviae Miltiorrhizae, Scorpio, Herba speranskiae tuberculatae, Herba Lycopodii, Caulis Spatholobi, Fructus Jujubae, Radix Glycyrrhizae combines, and produce synergism, make it that there is suppressing the hyperactive liver to relieve the wind syndrome, temperature compensation Liver and kidney, expelling wind and relieving convulsion, tranquillizing and allaying excitement, effect of channels sootheing and network vessel quickening, thus effectively can treat parkinson disease.
The effect of Chinese medicine of the present invention:
Wherein:
Rhizoma Gastrodiae: be the dry tuber of orchid Rhizoma Gastrodiae Gastrodia elata Blume..Nature and flavor: sweet are flat.Return Liver Channel.Effect: suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.Dizzy for having a headache, numb limbs and tense tendons, infantile convulsion, epilepsy clonus, tetanus.Pharmaceutical research shows, Rhizoma Gastrodiae has significantly calm and anticonvulsant action.Rhizoma Gastrodiae is sweet flat, specially enter Liver Channel, function endogenous wind stopping relieving convulsion, and Gan Run is not strong, acts on gentle, the panacea of endogenous wind for it, can be used for treating the liver-wind stirring up internally caused by the various cause of disease, and infantile convulsion is twitched, no matter cold and heat and asthenia and sthenia, and all can compatibility application.
Colla cornus cervi: for Cornu Cervi is endured through decocting, concentrated the solid gum made.Nature and flavor: sweet, salty, temperature.Return kidney, Liver Channel.Effect: temperature compensation Liver and kidney, beneficial intensive culture blood.For sexual impotence spermatorrhea, the acid of waist knee joint is cold, asthenia weakness and emaciation, metrostaxis, and hematuria of having blood in stool, carbuncle of yin nature swells and ache." book on Chinese herbal medicine converges and says ": Colla cornus cervi, kidney-Yang invigorating, gas of enriching blood, spermatogenesis marrow, the medicine of warm muscles and bones also.The main damaging the spleen and stomach labor of front Gu is exhausted, lumbago weakness and emaciation, gas marrow muscles and bones the intestines and stomach of enriching blood.Treatment of deficiency-syndrome by reinforcement, damage person trains it, and exhausted person continues it, timid person strong it, cold person warms up it, and this is the essence of blood genuss, and comparatively vegetation is merciless, more increasing one power of raising.
Zaocys: be the dry body of Colubridae animal Zaocys Zaocys dhumnades (Cantor).Nature and flavor: sweet are flat.Return Liver Channel.Effect: dispel the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.
Os Draconis: Os Draconis be ancient times mammal as if the Skeletal Fossils of class, rhinoceros class, Hippocampal cortex etc.Nature and flavor: sweet, puckery are flat.Enter the heart, liver, kidney, large intestine channel.Effect: tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, and seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.Os Draconis matter weight, has the effect of good tranquillizing the mind by relieving convulsion, and available to control various mind uneasy, insomnia and dreamful sleep, tinnitus etc.
Radix Asparagi: be the dried root of liliaceous plant Radix Asparagi Asparagus cochinchinensis (Lour.) Merr..Nature and flavor: sweet, bitter, cold.Return lung, kidney channel.Effect: nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid.For dryness of the lung dry cough, pertussis expectorant sticks, dry throat and mouth, dryness of the intestine constipation.Radix Asparagi and Radix Ophiopogonis often use simultaneously, to strengthen nourishing lung-YIN, the effect of the relieving restlessness that clears away heart-fire.
Radix Ophiopogonis: be the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl..Nature and flavor: sweet, micro-hardship, to be slightly cold.GUIXIN, lung, stomach warp.Effect: reinforcing stomach reg fluid, nourishing lung-YIN, clear away heart-fire relieving restlessness.Radix Ophiopogonis can clear away heart-fire in yin nourishing, and relieving restlessness is calmed the nerves.The heart-nutriment, fever aggravated at night is entered with controlling warm febrile disease.
Cornu Cervi Degelatinatum: for Cornu Cervi removes photoresist the hornblock (boil Colla cornus cervi remaining bone slag) of matter.Nature and flavor: salty, warm.Return liver, kidney channel.Effect: warming the kidney to activate YANG, astringing to arrest bleeding.For spleen kidney yang flaccidity, lack of appetite and vomiting, leucorrhea, enuresis frequent micturition, metrostaxis, carbuncle sucutaneous nodule.
Margarita powder: the Margarita formed for bivalve irriates such as Pteriidae animal Pteria martensii Dunker Pteria martensii (Dunker), Unionidae animal hydriopsis cumingii Hyriopsis cumingii (Lea) or cristaria plicata Cristaria plicata (Leach).Margarita powder gets clean Margarita, fine ground, makes most fine powder according to elutriation (appendix II D).Nature and flavor: sweet, salty, cold.GUIXIN, Liver Channel.Effect: arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation.For insomnia of palpitating with fear, infantile convulsion epilepsy, the raw nebula of order, skin infection is not held back." detailed outline ": peace soul, only seminal emission, nebulousurine, separates pox furunculosis.
Succinum: the resin of some pinaceae plant, is embedded in stratum year fossil sample material for a long time.Nature and flavor: sweet are flat.Enter the heart, liver, small intestine meridian.Effect: calm, diuresis, invigorates blood circulation.For infantile convulsion, epilepsy, cardiopalmus, insomnia, dysuria, dysurea, hematuria, amenorrhea." Bencao Jingshu ": succinum, specially enters blood system.The main blood of the heart, blood stored in the liver, the popular feeling enters liver, therefore energy repercussive blood also.This medicine is wear down the property of oozing profit after all, unfavorable empty people.Mostly from pungent temperature medicine then promoting the circulation of blood removing blood stasis, ooze the medicine then capable water of sharp key from what is said or talked about, from metal and stone town pendant medicine then tranquilizing mind.
Agkistrodon: be the dry body of Viperidae animal Agkistrodon Agkisrrodon acutus (Guenther).Nature and flavor: sweet, salty, temperature; Poisonous.Return Liver Channel.Effect: dispel the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus, leprosy scabies.
Carapax Trionycis: be the carapace of Trionychidae animal Trionyx sinensis Wiegmann Trionyx sinensis Wiegmann.Nature and flavor: salty, are slightly cold.Return liver, kidney channel.Effect: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea , WEIJIA, chronic malaria malaria with splenomegaly.Carapax Trionycis is salty-cold, nourishing YIN for suppressing the hyperactive YANG, brings down a fever except steaming. Papillary, and play replenishing YIN and removing heat altogether except effect of steaming, be used for the treatment of fever due to yin deficiency, hectic fever due to YIN-deficiency, infantile malnutrition; Or the calentura later stage, waste heat not to the greatest extent person.
Carapax et Plastrum Testudinis: be sternite and the carapace of Testudinidae animal chinemys reevesii.Nature and flavor: salty, sweet, be slightly cold.Return liver, kidney, heart channel.Effect: nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, Gu through only collapsing, reinforcing the heart of nourishing blood.Carapax et Plastrum Testudinis contains several amino acids, protein, fat and calcium salt etc. containing bone gelatin, hydrolysate.Cure mainly hyperactivity of YANG due to deficiency of YIN, yin asthenia generating intrinsic heat, stirring-up of pathogenic wind in the interior resulting from deficiency.To suffer from a deficiency of the kidney the atrophic debility of bones, infantile metopism.Deficiency of YIN-blood, palpitation with fear, insomnia, forgetful.This product energy tonifying kidney-yin is appointed with Gu Chong, again heat clearing away cold in nature, and holding concurrently can cooling blood for hemostasis.For the menorrhagia of YinXuXueRe, metrorrhagia and metrostaxis.This product can nourish blood reinforcing the heart, can be used for insomnia forgetfulness.
The Radix Paeoniae Alba: be the dry root of dicotyledon ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: cool, picric acid, is slightly cold.Effect: easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receives antiperspirant.Research shows: the paeoniflorin contained in the Radix Paeoniae Alba has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.This product energy nourishing the liver blood, holding back liver-yin, subduing the hyperfunction of the liver sun, dispersing liver-energy, can delay again that contraction is anxious, relieve the pain pain, is the good medicine of the various pain for the treatment of Liver Channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " purgation of spleen excess heat, only abdomen pain, sealing rushes down, and receives adverse flow of liver-QI pain, takes good care of conscience spleen channel blood, relax through sending down the abnormal ascending QI, only irritability pain." " herbal classic " Radix Paeoniae, though respectively in vain not red, the two is master to some extent respectively.So seek and unravel silk it and cure mainly all diseases, one is that replenishing blood and nourishing liver spleen is Kidney-Yin, and receives and take the photograph the at random of temper, and throwing off restraint of irritability is horizontal, then the Radix Paeoniae Alba.
Cornu Saigae Tataricae powder: Cornu Saigae Tataricae is the angle of bovid sahilite Saiga tatarica Linnaeus.Cornu Saigae Tataricae powder gets Cornu Saigae Tataricae, smashes, and is ground into fine powder.Nature and flavor: salty, cold.Return liver, heart channel.Effect: suppressing the hyperactive liver to relieve the wind syndrome, liver heat removing and eyesight improving, loose blood removing toxic substances.For the hot infantile convulsion of height, coma convulsion is fainted, and eclamposia is twitched, and epilepsy is gone mad, and has a headache dizzy, cataract, maculae caused by violent heat pathogen, carbuncle sore tumefacting virus." property of medicine opinion ": all pyretic toxicity wind can be controlled and attack note, in vicious wind soldier dead, dazed and confusedly fail to see people; Loose puerperal, the blood centre of punch was unhappy, burnt last wine and took it; Main pediatric epilepsy scared, miasma of transforming mountains, can dispelling malignant blood.
Radix Notoginseng powder: be the dry root of panax araliaceae plant Panax notoginseng (Burk.) F. H. Chen.Radix Notoginseng powder gets Radix Notoginseng, cleaning, drying, fine ground powder.Nature and flavor: sweet, micro-hardship, temperature.Return liver, stomach warp.Effect: dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.Record in " book on Chinese herbal medicine is looked for the truth ": Radix Notoginseng, common people only know that function is stopped blooding bitterly, hardly realize bitterly because blood stasis then aches work, and blood is because only applying loose then blood.The bitter temperature of Radix Notoginseng abnormal smells from the patient, can in its blood stasis of blood systemization.
Fructus Corni: be the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb. et Zucc..Nature and flavor: sour, puckery, tepor.Return liver, kidney channel.Effect: liver and kidney tonifying, essence astringing and desertion stemming.Cure mainly and have a dizzy spell, deafness and tinnitus, soreness of the waist and knees, emission and spermatorrhea, frequent micturition, incessant sweating due to debility, woman uterine bleeding.The sour-puckery flavor of Fructus Corni, can restrain solid de-, all gas body fluid persons of decoherencing, and available this product, with needed for card, is equipped with the same use of the medicine effected a permanent cure.
Fructus Schisandrae Chinensis: be the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or schisandra chinensis Schisandra sphenanthera Rehd. et Wils..Nature and flavor: warm, sour, sweet.Return lung, the heart, kidney channel.Function: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis has inhibitory action to central nervous system, and volatile oil has the effects such as calmness, hypnosis, analgesia, anesthesia.For blood deficiency and yellow complexion, dizzy cardiopalmus, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores.Carry according to " book on Chinese herbal medicine is just ": its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, nothing unsuitable.
Arillus Longan: be the aril of Sapindaceae Euphoria plant Arillus Longan Dimocarpus longan Lour..Nature and flavor: sweet, temperature.GUIXIN, spleen channel.Effect: invigorating the heart and spleen, nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion." detailed outline ": food with Fructus Litchi for expensive, provide benefit then Arillus Longan be good, lid Fructus Litchi is hot in nature, and Arillus Longan property peace is also.Tight use and recipes for Saving Lives are controlled and are pondered over impairment caused by overstrain heart spleen and have GUIPI TANG, get sugariness and return spleen, can the justice of beneficial people's intelligence.
Squama Manis: this product is the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus.Nature and flavor: salty, be slightly cold.Return liver, stomach warp.Effect: stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.For Jing Bi WEIJIA, galactostasis, carbuncle sore tumefacting virus, arthralgia, numbness contracture.For amenorrhea due to stagnation of blood, lump in the abdomen lumps, the diseases such as rheumatic arthralgia, the contracture of muscle arteries and veins.Squama Manis is good at walking to alter, and property specially row is loose, can promoting blood circulation to remove blood stasis, current meridians, therefore availablely controls above-mentioned all kinds of disease.For carbuncle from the beginning of or the disease such as difficulty in discharging of pus.Squama Manis has effect of detumescence and apocenosis, and carbuncle can be made not become pus, and person disappears, and suppuration person's speed is burst.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia/miltiorrhizaBge.Nature and flavor: bitter, are slightly cold.Gui Jing: enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed.
Scorpio: be the dry body of Buthidae animal Scorpio Buthus martensii Karsch.Nature and flavor: pungent, flat, poisonous.Return Liver Channel.Effect: endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.This product is heated to 100 DEG C, 30min, and toxin can be eliminated.Scorpio master enters Liver Channel, can calm down liver-wind, again expel wind to dredge collateral, has good endogenous wind stopping relieving convulsion effect, can be used for the spasm tic that treatment a variety of causes causes.
Herba speranskiae tuberculatae: be Euphorbiaceae Speranskia plant speranskia tuberculata Speranskia tuberculata (Bunge) Baill., Balsaminaceae herbaceous plant Flos Impatientis Impatiens balsamina L., Bignoniaceae Incarvillea AJuss plant Herba Incarvilleae sinensis Incarvillea sinensis Lam., the herb of pulse family Vetch plant Herba Viciae Amoenae Vicia amoena Fisch. and the Herb of Ericaceae Gaultheria plant Caulis et folium gaultheriae yunnanensis Gaultheria yunnanensis (Franch.) Rehd..Nature and flavor: pungent, bitter, temperature.Slightly poisonous.Return liver, kidney channel.Effect: expelling wind and removing dampness, removing toxic substances pain relieving.Main air pain of dampness syndrome; Muscles and bones contracture; The disturbance of lower legs due to pathogenic cold and dampness; Lumbar strain; Paralysis; Amenorrhea; Eczema scrotum; Furuncle toxic swelling.
Herba Lycopodii: be the herb of Lycopodiaceae Lycopodium plant Lycopodium clavatum Lycopodium japonicum Thunb..Nature and flavor: bitter, pungent, warm.Return Liver Channel.Effect: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For anemofrigid-damp arthralgia, muscle arteries and veins contracture pain carbuncle.External is controlled osteopatia sprain and is swollen and ache.
Caulis Spatholobi: be the dry rattan of pulse family Leguminosae plant spatholobus suberectus Spatholobus suberectusDunn.Nature and flavor: bitter, sweet, temperature.Return liver, kidney channel.Effect: enrich blood, invigorates blood circulation, dredging collateral.This product promoting the circulation of blood is nourished blood, relaxing muscles and tendons and activating QI and blood in the collateral, for treatment passages through which vital energy circulates is not smooth, and the common medicine of channels discord disease.Control apoplexy numb hand and foot, quadriplegia.
Fructus Jujubae: be the dry mature fruit of Rhamnaceae jujube Fructus Jujubae Ziziphus jujuba Mill. var. inermis (Bunge) Rehd..Nature and flavor: sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.For tracheitis, enteritis, dysentery, metrorrhagia; Traumatic hemorrhage is controlled in external.For menoxenia, redly to collapse, leucorrhea." herbal classic ": main trusted subordinate's pathogen, regulating the spleen and stomach supports spleen, helps 12 warps.Flat gastric qi, logical nine orifices, mends weak breath, few body fluid, not enough, frightened in body, heaviness of limbs, and hundred medicines." book on Chinese herbal medicine is new again ": invigorating the spleen and replenishing QI, nourishing kidney warming the stomach, controls the deficiency of YIN.
Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.
Side's solution of the present invention is: Rhizoma Gastrodiae suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion in side, Colla cornus cervi temperature compensation Liver and kidney, benefit intensive culture blood, Zaocys is expellingged wind and relieving convulsion, Os Draconis tranquillizing and allaying excitement, Radix Asparagi, nourishing YIN to relieve dryness Radix Ophiopogonis, clear away heart-fire relieving restlessness, above Six-element is monarch drug altogether, first start with from the surface symptoms of disease, expelling wind and relieving convulsion, suppressing the hyperactive liver to relieve the wind syndrome, be conducive to reduction of patient extremity spasm, the effect of trembling, secondly tranquillizing and allaying excitement is also had, temperature compensation Liver and kidney, clear away heart-fire the effect of relieving restlessness, nurse one's health from the health of entirety to patient, Each performs its own functions to make the five internal organs of patient, take care of health with scholar other organs of body, thus reach the object of disease therapy.Cornu Cervi Degelatinatum warming the kidney to activate YANG, Margarita powder, succinum tranquillizing and allaying excitement, Agkistrodon dispelling wind and removing obstruction in the collateral, Carapax Trionycis, Carapax et Plastrum Testudinis nourishing YIN for suppressing the hyperactive YANG, the Radix Paeoniae Alba is enriched blood easing the affected liver, suppressing the hyperactive liver pain relieving, Cornu Saigae Tataricae powder suppressing the hyperactive liver to relieve the wind syndrome, loose blood removing toxic substances, Radix Notoginseng powder dissipating blood stasis stops blooding, a few taste is ministerial drug altogether above, not only can increase the drug effect of monarch drug temperature compensation Liver and kidney, tranquillizing and allaying excitement, the easing the affected liver but also softer carrying out is enriched blood, the medicine that these drug effects are soft, be conducive to old man and nurse one's health health, reduce side effect, accelerate the recovery of patient.Fructus Corni the liver and the kidney tonifying, Fructus Schisandrae Chinensis supplementing QI for promoting the production of body fluid, QI invigorating mind calming, Chinese angelica blood supplementing is invigorated blood circulation, Arillus Longan invigorating the heart and spleen, nourishing blood to tranquillize the mind, Squama Manis expel wind to dredge collateral, Radix Salviae Miltiorrhizae nourishing blood to tranquillize the mind, Scorpio relieves dizziness, high fever, infantile convulsions, epilepsy, etc. spasmolytic, Herba speranskiae tuberculatae, Herba Lycopodii expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, and Caulis Spatholobi promoting the circulation of blood is nourished blood, Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, a few taste is adjuvant drug altogether above, increases overall drug effect, reduces the toxic and side effects of medicine simultaneously, Radix Glycyrrhizae priming is returned through, coordinating the actions of various ingredients in a prescription, for making medicine.All medicine compatibilities in side, the monarch and his subjects pull together, help and make auxiliary altogether, make it to have suppressing the hyperactive liver to relieve the wind syndrome, temperature compensation Liver and kidney, expelling wind and relieving convulsion, effect of tranquillizing and allaying excitement, channels sootheing and network vessel quickening, can effectively alleviate Parkinsonian symptom, thus treatment parkinson disease.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Rhizoma Gastrodiae 10-20 part, Colla cornus cervi 4-14 part, Zaocys 5-15 part, Os Draconis 19-29 part, Radix Asparagi 7-17 part, Radix Ophiopogonis 7-17 part, Cornu Cervi Degelatinatum 7-17 part, Margarita powder 5-15 part, succinum 5-15 part, Agkistrodon 7-17 part, Carapax Trionycis 7-17 part, Carapax et Plastrum Testudinis 7-17 part, Radix Paeoniae Alba 10-20 part, Cornu Saigae Tataricae powder 1-5 part, Radix Notoginseng powder 1-5 part, Fructus Corni 7-17 part, Fructus Schisandrae Chinensis 7-17 part, Radix Angelicae Sinensis 13-23 part, Arillus Longan 7-17 part, Squama Manis 4-14 part, Radix Salviae Miltiorrhizae 19-29 part, Scorpio 5-15 part, Herba speranskiae tuberculatae 13-23 part, Herba Lycopodii 15-25 part, Caulis Spatholobi 15-25 part, Fructus Jujubae 10-20 part, Radix Glycyrrhizae 4-14 part.
Wherein be preferably: 15 parts, Rhizoma Gastrodiae, Colla cornus cervi 9 parts, Zaocys 10 parts, Os Draconis 24 parts, Radix Asparagi 12 parts, Radix Ophiopogonis 12 parts, Cornu Cervi Degelatinatum 12 parts, Margarita powder 10 parts, succinum 10 parts, Agkistrodon 12 parts, Carapax Trionycis 12 parts, Carapax et Plastrum Testudinis 12 parts, the Radix Paeoniae Alba 15 parts, Cornu Saigae Tataricae powder 3 parts, Radix Notoginseng powder 3 parts, Fructus Corni 12 parts, Fructus Schisandrae Chinensis 12 parts, Radix Angelicae Sinensis 18 parts, Arillus Longan 12 parts, Squama Manis 9 parts, Radix Salviae Miltiorrhizae 24 parts, Scorpio 10 parts, Herba speranskiae tuberculatae 18 parts, Herba Lycopodii 20 parts, Caulis Spatholobi 20 parts, 15 parts, Fructus Jujubae, Radix Glycyrrhizae 9 parts.
Medicine of the present invention can adopt the conventional fabrication process of Chinese medicine preparation, can be made into said dosage form on any one pharmaceutics, as pill, powder, tablet, capsule, granule, syrup, oral liquid etc.Such as can by these crude drug grinds into fine powder, granularity is 80-120 order, gained fine powder is dropped into hybrid medicine blender and fully mixes, make powder warm water and take after mixing it with water.Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.
The preferred preparation method of the present invention is decoction, and its preparation method is as follows:
Step one: by weight proportion of the present invention, takes succinum and grinds, and crosses 180 mesh sieves, and Margarita powder, Cornu Saigae Tataricae powder, Radix Notoginseng mix homogeneously in bowl, for subsequent use;
Step 2: by weight proportion of the present invention, take Os Draconis, Cornu Cervi Degelatinatum, Carapax Trionycis, Carapax et Plastrum Testudinis, Squama Manis put into marmite, add water 4-5 centimetre, first boils with high heat, then transfer slow fire boiling 20-30 minute to, the filtrate of filtration, for subsequent use;
Step 3: add water the medicinal residues in step one 4-5 centimetre, then take Radix Asparagi by weight proportion of the present invention, Radix Ophiopogonis, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae put into marmite, decoct 30-40 minute, add Rhizoma Gastrodiae, Zaocys, Agkistrodon, Fructus Corni, Fructus Schisandrae Chinensis, Arillus Longan, Scorpio, Herba speranskiae tuberculatae, Herba Lycopodii, Caulis Spatholobi, Fructus Jujubae afterwards, continue to decoct 20-30 minute, filter, waste, obtain filtrate, for subsequent use
Step 4: the filtrate that combining step two and step 3 obtain, and Colla cornus cervi is put in molten in hot soup while hot, the medicinal liquid this decocted is poured in step one and is placed with in the bowl of medicated powder, takes after mixing it with water, both the Parkinsonian Chinese medicine decoction for the treatment of of the present invention.
Medicine of the present invention has suppressing the hyperactive liver to relieve the wind syndrome, temperature compensation Liver and kidney, expellings wind and relieving convulsion, effect of tranquillizing and allaying excitement, channels sootheing and network vessel quickening, and curative effect is obvious, have no side effect, taking convenience, cheap, according to clinical 120 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 90%, two the total effective rate course for the treatment of 95%.
Detailed description of the invention
Embodiment one, 10 parts, Rhizoma Gastrodiae, Colla cornus cervi 4 parts, Zaocys 5 parts, Os Draconis 19 parts, Radix Asparagi 7 parts, Radix Ophiopogonis 7 parts, Cornu Cervi Degelatinatum 7 parts, Margarita powder 5 parts, succinum 5 parts, Agkistrodon 7 parts, Carapax Trionycis 7 parts, Carapax et Plastrum Testudinis 7 parts, the Radix Paeoniae Alba 10 parts, Cornu Saigae Tataricae powder 1 part, Radix Notoginseng powder 1 part, Fructus Corni 7 parts, Fructus Schisandrae Chinensis 7 parts, Radix Angelicae Sinensis 13 parts, Arillus Longan 7 parts, Squama Manis 4 parts, Radix Salviae Miltiorrhizae 19 parts, Scorpio 5 parts, Herba speranskiae tuberculatae 13 parts, Herba Lycopodii 15 parts, Caulis Spatholobi 15 parts, 10 parts, Fructus Jujubae, Radix Glycyrrhizae 4 parts.
Embodiment two, 15 parts, Rhizoma Gastrodiae, Colla cornus cervi 9 parts, Zaocys 10 parts, Os Draconis 24 parts, Radix Asparagi 12 parts, Radix Ophiopogonis 12 parts, Cornu Cervi Degelatinatum 12 parts, Margarita powder 10 parts, succinum 10 parts, Agkistrodon 12 parts, Carapax Trionycis 12 parts, Carapax et Plastrum Testudinis 12 parts, the Radix Paeoniae Alba 15 parts, Cornu Saigae Tataricae powder 3 parts, Radix Notoginseng powder 3 parts, Fructus Corni 12 parts, Fructus Schisandrae Chinensis 12 parts, Radix Angelicae Sinensis 18 parts, Arillus Longan 12 parts, Squama Manis 9 parts, Radix Salviae Miltiorrhizae 24 parts, Scorpio 10 parts, Herba speranskiae tuberculatae 18 parts, Herba Lycopodii 20 parts, Caulis Spatholobi 20 parts, 15 parts, Fructus Jujubae, Radix Glycyrrhizae 9 parts.
Embodiment three, 20 parts, Rhizoma Gastrodiae, Colla cornus cervi 14 parts, Zaocys 15 parts, Os Draconis 29 parts, Radix Asparagi 17 parts, Radix Ophiopogonis 17 parts, Cornu Cervi Degelatinatum 17 parts, Margarita powder 15 parts, succinum 15 parts, Agkistrodon 17 parts, Carapax Trionycis 17 parts, Carapax et Plastrum Testudinis 17 parts, the Radix Paeoniae Alba 20 parts, Cornu Saigae Tataricae powder 5 parts, Radix Notoginseng powder 5 parts, Fructus Corni 17 parts, Fructus Schisandrae Chinensis 17 parts, Radix Angelicae Sinensis 23 parts, Arillus Longan 17 parts, Squama Manis 14 parts, Radix Salviae Miltiorrhizae 29 parts, Scorpio 15 parts, Herba speranskiae tuberculatae 23 parts, Herba Lycopodii 25 parts, Caulis Spatholobi 25 parts, 20 parts, Fructus Jujubae, Radix Glycyrrhizae 14 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
Accept out-patient 120 example for medical treatment, wherein male 68 people, women 52 people, M-F is 1.3:1, age 46-80 year, 67 years old mean age, course of disease 3-8 is not etc.
Two, Therapeutic Method
According to Medications Example two of the present invention, and the decoction that preferred preparation method is made, getting a daily dose, decocting, take at twice, 10 days is a course for the treatment of.
Three, efficacy assessment standard:
1, cure: clinical symptom disappearance, trembling of limbs, muscular rigidity, lumbering phenomenon disappear, and sensation and function of deglutition are all normal, and life can take care of oneself;
2, take a turn for the better: clinical symptoms is controlled, and every physical signs takes a turn for the better all to some extent;
3, do not heal: patient clinical symptom is without any improvement even to be increased the weight of.
Four, therapeutic outcome statistics
Have and above-mentionedly can to find out, Chinese medicine of the present invention has good clinical effectiveness in treatment parkinson disease, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.
Model case and curative effect:
Case one, Huang, man, 52 years old, the involuntary vibration of extremity was there is in patient before half a year, tremble after shifting one's position and alleviate or disappear, there is muscular rigidity in patient afterwards, and have slight moving obstacle, and patient removes examination in hospital, be diagnosed as parkinson disease, adopt made decoction in the embodiment of the present invention two, after taking two courses for the treatment of, the phenomenon of patient's trembling of limbs is clearly better, the phenomenon of muscular rigidity disappears completely, after continue again to take a course for the treatment of, patient's Ambulatory Activity is than before obviously flexibly, and life can take care of oneself.
Case two, Lu, female, 60 years old, patient household describes suffers from parkinson disease about 1 year, lurchs on foot stiff, has obvious festination, it is blunt gradually that language also becomes, and patient adopts made preparation in the embodiment of the present invention two, after taking two courses for the treatment of, patient's action and linguistic competence get a promotion, and can exchange normally, limbs flutter phenomenon is taken a turn for the better, continue two courses for the treatment of of use, patient's walking and activity are all very flexible, and can do some simple housework, life can take care of oneself.

Claims (4)

1. the Parkinsonian Chinese medicine preparation for the treatment of, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Rhizoma Gastrodiae 10-20 part, Colla cornus cervi 4-14 part, Zaocys 5-15 part, Os Draconis 19-29 part, Radix Asparagi 7-17 part, Radix Ophiopogonis 7-17 part, Cornu Cervi Degelatinatum 7-17 part, Margarita powder 5-15 part, succinum 5-15 part, Agkistrodon 7-17 part, Carapax Trionycis 7-17 part, Carapax et Plastrum Testudinis 7-17 part, Radix Paeoniae Alba 10-20 part, Cornu Saigae Tataricae powder 1-5 part, Radix Notoginseng powder 1-5 part, Fructus Corni 7-17 part, Fructus Schisandrae Chinensis 7-17 part, Radix Angelicae Sinensis 13-23 part, Arillus Longan 7-17 part, Squama Manis 4-14 part, Radix Salviae Miltiorrhizae 19-29 part, Scorpio 5-15 part, Herba speranskiae tuberculatae 13-23 part, Herba Lycopodii 15-25 part, Caulis Spatholobi 15-25 part, Fructus Jujubae 10-20 part, Radix Glycyrrhizae 4-14 part.
2. the Parkinsonian Chinese medicine preparation for the treatment of according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: 15 parts, Rhizoma Gastrodiae, Colla cornus cervi 9 parts, Zaocys 10 parts, Os Draconis 24 parts, Radix Asparagi 12 parts, Radix Ophiopogonis 12 parts, Cornu Cervi Degelatinatum 12 parts, Margarita powder 10 parts, succinum 10 parts, Agkistrodon 12 parts, Carapax Trionycis 12 parts, Carapax et Plastrum Testudinis 12 parts, the Radix Paeoniae Alba 15 parts, Cornu Saigae Tataricae powder 3 parts, Radix Notoginseng powder 3 parts, Fructus Corni 12 parts, Fructus Schisandrae Chinensis 12 parts, Radix Angelicae Sinensis 18 parts, Arillus Longan 12 parts, Squama Manis 9 parts, Radix Salviae Miltiorrhizae 24 parts, Scorpio 10 parts, Herba speranskiae tuberculatae 18 parts, Herba Lycopodii 20 parts, Caulis Spatholobi 20 parts, 15 parts, Fructus Jujubae, Radix Glycyrrhizae 9 parts.
3. the Parkinsonian Chinese medicine preparation for the treatment of according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.
4. the Parkinsonian Chinese medicine preparation for the treatment of according to claim 3, its preparation method is as follows: step one: by weight proportion of the present invention, takes succinum and grinds, and crosses 180 mesh sieves, with Margarita powder, Cornu Saigae Tataricae powder, Radix Notoginseng mix homogeneously in bowl, for subsequent use; Step 2: by weight proportion of the present invention, take Os Draconis, Cornu Cervi Degelatinatum, Carapax Trionycis, Carapax et Plastrum Testudinis, Squama Manis put into marmite, add water 4-5 centimetre, first boils with high heat, then transfer slow fire boiling 20-30 minute to, the filtrate of filtration, for subsequent use; Step 3: add water the medicinal residues in step one 4-5 centimetre, then take Radix Asparagi by weight proportion of the present invention, Radix Ophiopogonis, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae put into marmite, decoct 30-40 minute, add Rhizoma Gastrodiae, Zaocys, Agkistrodon, Fructus Corni, Fructus Schisandrae Chinensis, Arillus Longan, Scorpio, Herba speranskiae tuberculatae, Herba Lycopodii, Caulis Spatholobi, Fructus Jujubae afterwards, continue to decoct 20-30 minute, filter, waste, obtain filtrate, for subsequent use; Step 4: the filtrate that combining step two and step 3 obtain, and Colla cornus cervi is put in molten in hot soup while hot, the medicinal liquid this decocted is poured in step one and is placed with in the bowl of medicated powder, takes after mixing it with water, both the Parkinsonian Chinese medicine decoction for the treatment of of the present invention.
CN201510250138.1A 2015-05-18 2015-05-18 Traditional Chinese medicine preparation for treating Parkinson's disease and preparation method thereof Pending CN104800610A (en)

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CN105535429A (en) * 2015-12-29 2016-05-04 河南中医学院 Traditional Chinese medicine for treating Parkinson's disease and preparation method thereof
CN107929611A (en) * 2017-12-19 2018-04-20 薛瑞山 A kind of plaster and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105535429A (en) * 2015-12-29 2016-05-04 河南中医学院 Traditional Chinese medicine for treating Parkinson's disease and preparation method thereof
CN107929611A (en) * 2017-12-19 2018-04-20 薛瑞山 A kind of plaster and preparation method thereof

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