CN102579818A - Traditional Tibetan medicine composition, preparation method thereof and application - Google Patents
Traditional Tibetan medicine composition, preparation method thereof and application Download PDFInfo
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Abstract
The invention discloses a traditional Tibetan medicine composition, takes examples by the experience of traditional Tibetan medicine in prevention and treatment of kidney deficiency diseases, selects traditional Tibetan medicines for reasonable matching, and provides the traditional Tibetan medicine composition with herbal medicines serving as main components. The Tibetan medicine composition adopts agama himalayana, radix pleurospermi tibetanic, rhizoma polygonati, Himalaya mirabilis jalapa, caltrop, radix asparagi, medusa maxim and milk as a basic formula, and under a preferable condition, other Tibetan medicine components including seeds of pomegranates, red flowers, cordyceps sinensis, conic gymnadenia tuber, gastrodia elata and the like can be further added. A preparation method of the Tibetan medicine composition and the application of the method in the preparation of the medicine for treating the kidney deficiency diseases are further provided. The traditional Tibetan medicine composition directly acts on a human body visceral organ, is verified by clinic experiments to be capable of being applied to treatment of deficiency of kidney yin and yang diseases, is remarkable in medicine efficiency, short in curative period and free of toxic and side effect.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of Tibetan medicine compositions that can be used to prepare treatment kidney deficiency disease drug.
Background technology
The notion of traditional medicine said " kidney " and western medicine said " kidney " have very big-difference.The said kidney of doctor trained in Western medicine is an anatomical concepts, refers to a pair of organ in the urinary system.Kidney in the traditional medicine is a functional concept, the functional activity of a plurality of systems in the general reference human body, and be not a certain certain organs.Kidney in the traditional medicine is participated in most of biological function of the vital movement, particularly regulating and controlling hormonal system of human body hormonal system, nervous system, urinary system, motor system, respiratory system, digestive system, reproductive system 7 big systems.The vital essence of kidney is dominated the whole life process of human growth, growth, maturation, death, so kidney is called " the congenital foundation " by traditional medicine.
Suffering from a deficiency of the kidney is the peculiar notion of traditional medical theory, and general reference is because of the not enough a plurality of systems disease that causes of kidney essense gas negative and positive in the human body.According to the yin or yang excess difference that declines partially of essence in kidney, suffering from a deficiency of the kidney comprises the different performances such as void, instability of kidney QI, failure of the kidney in receiving QI, kidney yin kidney yang two void, deficiency of the kidney yin hyperactivity of fire thanks to of deficiency of kidney-YIN, kidney yang.Clinically, generally be divided into two kinds of syndrome of deficiency of kidney yin and syndrome of deficiency of kidney-YANG briefly.The main performance of suffering from a deficiency of the kidney is: Hiccough and deaf, loss of hairs withered worried, luxated tooth is sparse, aching pain in waist and back, shank are soft, talalgia, sexual function are not normal, CHI-pulse being weak etc.Deficiency of the kidney yin can have dysphoria with feverish sensation in the chest palms and soles, insomnia, dreaminess, night sweat, dry mouth and throat concurrently, has a dizzy spell on the symptom basis of suffering from a deficiency of the kidney, nocturnal emission, afternoon flushed cheeks, the few tongue of red tongue or symptoms such as crackle, thready and rapid pulse are arranged.Insufficiency of kidney-YANG can have pale complexion, cold extremities concurrently, creeping chill, clear urine in large amounts, watery diarrhea with indigested food are arranged below the abdomen, has loose bowels just before dawn on the symptom basis of suffering from a deficiency of the kidney, frequent micturition, emission, impotence and premature ejaculation, the back heeltap of drowning, leukorrhagia are rare clearly, infertility, hydroderma, foot is swollen, lower limb is swollen, light red tongue is fat, white and moist fur, faint and weak pulse and symptom such as slow.
In the Tibetanmedicine rationale, the three big factors that exist in the human body, seven kinds of materials and three kinds of material bases that the common formation of Excreta earns a bare living.Three big factors " are swelled ", among " red crust ", " Baconic ", grand is gas, accumulates in brains, cardiopulmonary and the skeleton, be responsible for breathe, circulation, sensation, motion; Red crust is a fire, is dispersed in liver and the blood generation of facilitating digestion, absorption and heat energy and wisdom; Baconic is a water and soil, is present in spleen, stomach, intravesical, can regulate digestion and water balance, influences people's body weight and disposition.In the human body, kidney has " water ", " soil " character, has the body fluid of generation and metabolic important function.Because grand in the body, red crust, Baconic's three categories of etiologic factors procatarxis are inside and outside, and certain is former thereby occur can causing renal function unbalance when too prosperous or on the decline, and body disease takes place.Particularly human body is in wet environment or reason such as contact cold water etc. for a long time, and has a liking for sweet or have a liking for raw and cold dietary habit etc., all can make the vital essence negative and positive of kidney in the human body not enough, causes the pathological changes of multiple human body physiological system, and causes the disease of suffering from a deficiency of the kidney.Tradition Tibetan medicine theory is divided into 8 major types with kidney disease; Wherein the suffer from a deficiency of the kidney disease of the renal function imbalance that is mainly cold pathological changes, the described deficiency of kidney-YIN of similar Chinese medicine, kidney yang are lost different manifestations such as void, instability of kidney QI, failure of the kidney in receiving QI, kidney yin kidney yang two void, deficiency of the kidney yin hyperactivity of fire.The Tibetan medicine clinically, generally also will suffer from a deficiency of the kidney and briefly be divided into triumphant plan card (insufficiency of kidney-YANG) and two kinds of triumphant normal cards (deficiency of the kidney yin).
Healthwise evaluation with western medicine; The alleged disease of suffering from a deficiency of the kidney of traditional medicine is not special finger kidney organ's a pathological changes, and it belongs to the sub-health state of the multiple functional system function of body comprehensive pathological changes of the uncomfortable body that causes or the decline of animal economy function level in essence.
Tibetanmedicine in the traditional medicine results from area, China Qinghai-Tibet Platean; Long-term specific aim alleviates with control because height above sea level, air drying be thin etc., and the plateau severe environmental conditions takes place with disease to the physical function burden that the local resident causes, and aspect the functional activity adjusting of human body multisystem, is accumulating a large amount of experiences.
Summary of the invention
The object of the invention is exactly the deficiency to prior art, and a kind of Tibetan medicine compositions that can be used to prepare treatment kidney deficiency disease drug is provided.
For realizing above-mentioned purpose, technical scheme of the present invention is following:
A kind of Tibetan medicine compositions is characterized in that: contain 10～60 parts of Agama himalayana, 40～80 parts of Herba pleurospermi thomsoniis, 40～70 parts of Rhizoma Polygonatis, 40～60 parts of Himalaya Mirabilis jalapas, 40～70 parts of Fructus Tribulis, 40～60 parts of Radix Asparagi, 20～50 parts of Saussurea medusa Maxim., 20～40 parts in milk.
In the above-mentioned Tibetan medicine compositions:
Agama himalayana is recorded in " first of the Sanitation Ministry medicine standard Tibetan medicine " (standard numbering WS3-BC-0102-95, Tibetan medicine title: hide crust), is the dry all of Iguanidae animal Agama himalayana (Agama himalayana).Main effect is Yang nourishing-strengthening.Be used for the renal cold disease, sexual impotence, diseases such as seminal emission.
Herba pleurospermi thomsonii (Tibetan medicine title: add) is the dry herb of dicotyledon medicine Umbelliferae rib apium plant Herba pleurospermi thomsonii (Pleurospermum Hoffm).Main effect is regulating QI to relieve pain, blood circulation promoting and blood stasis dispelling.
Rhizoma Polygonati (Tibetan medicine title: La Ni), be the dry rhizome of liliaceous plant Yunnan Rhizoma Polygonati (Polygonatum kingianum Coll.et Hemsl.), Rhizoma Polygonati (P.sibiricum Red.) or Polygonatum cyrtonema Hua (P.cyrtonema Hua).Return spleen, lung, kidney channel.Main effect is spleen reinforcing, the lung moistening and production of body fluid promoting, is used for weakness of the spleen and stomach, deficiency of the lung cough caused by dryness, interior-heat and quenches one's thirst.
Radix Mirabilis himalaicae is recorded in " Tibetan medicine is promulgated by the ministries or commissions of the Central Government " (standard No.: WS3-BC-0103-95, Tibetan language title: crust Zhu), be the dry root of Nyctaginaceae plant Radix Mirabilis himalaicae (Mirabilis himalaica (Edgew.) Heim.).Function is the kidney warming, granulation promoting, diuresis, calculus, yellow fluid reducing with curing mainly.Be used for cold syndrome of the stomach, renal cold, following coldness of the body, sexual impotence edema, vesical calculus, lumbago, arthralgia, yellow fluid pain.
Fructus Tribuli (Tibetan medicine title: Sai Ma), be the dry mature fruit of zygophyllaceae plant Fructus Tribuli (Tribulus terrestris L.).Return Liver Channel.Main effect is the suppressing the hyperactive liver resolving depression, and promoting blood circulation by removing wind makes eye bright, and is antipruritic.It is dizzy to be used to have a headache, distending pain in the chest and hypochondrium, and breast closes acute mastitis, conjunctival congestion cataracta, rubella pruritus.
Radix Asparagi is the tuber of Liliaceae asparagus plant Radix Asparagi (Asparagus cochinchinensis).Main effect is to control the consumptive lung disease lung abscess, and vomiting pus is spitted blood, phlegmatic cough dyspnea with rapid and short breath, the choke universe of quenching one's thirst.The foot burning pain, asthenia hectic fever due to YIN-deficiency, the deficiency of YIN have the card of fire.
Saussurea medusa Maxim. (the Tibetan medicine title: just fruit Soviet Union clings to) is the herb of Compositae phoenix hair Chrysanthemum plant Saussurea medusa Maxim. (Saussurea medusa Maxim.).Main effect is to cure mainly anthrax, contracture of the limbs, and aortic arch syndrome, He Ruhu, rheumatic arthropathy, the old skin infection, sword is hindered hemorrhage, cerebral concussion, amenorrhea, placenta retention.
Milk is the medicinal herbs most in use in the Tibetan medicine.According to " brilliant pearl book on Chinese herbal medicine " record, the flavor of milk and change flavor are all sweet, the property profit; The flourish color of effect, training unit, benefit is smart; Nutrition, long fat, naughty skin, ortho sleep are provided, and property is heavy and cool, and can neutralize is dispersed in heat energy in liver and the blood; Have regulate body temperature, keep complexion, give birth to wisdom, digestant effect.Wherein with the nourishing of cattle milk, sharp lung disease, lung obstinate disease, treatment blood, red crust complication, pestilence with the passing of time, frequent micturition disease, gas have some setbacks, expectorant is unfavorable, tiredly cut down unable, giddy and revolve, and can support Rong Zengli.
Above-mentioned Tibetan medicine compositions is the basis with traditional Tibetanmedicine to the pathological study of the disease of suffering from a deficiency of the kidney; To aching pain in waist and back, shank is soft, sexual function is not normal, insomnia, dreaminess, night sweat, dry mouth and throat, have a dizzy spell, frequent micturition, emission, impotence and premature ejaculation, infertility, hydroderma, foot is swollen, lower limb is swollen, light red tongue is fat, white and moist fur, faint and weak pulse and men and women's property such as slow are suffered from a deficiency of the kidney disease the temperature compensation of suiting the medicine to the illness and this Therapeutic Principle being processed support smart, the combined pharmaceutical formulation of QI and blood mediation.Analysis is by the cause of disease, the focus of the various disease conditions due to the kidney essense QI-insufficiency; Choose several flavors such as Rhizoma Polygonati, Herba pleurospermi thomsonii, Fructus Tribuli, Radix Mirabilis himalaicae, Radix Asparagi and be widely used in traditional Tibetan medicine material of suffering from a deficiency of the kidney and treating, selected Agama himalayana, Saussurea medusa Maxim., milk 3 flavor Tibetan medicine materials simultaneously for use.Wherein, though Agama himalayana records the effect of " being used for the renal cold disease " in Tibetan medicine standard promulgated by the ministries or commissions of the Central Government, be not disclosed at present any treatment and suffer from a deficiency of the kidney in the Tibetan medicine composition component of disease.This Tibetan medicine compositions, is carried out many-sided body function to the disease of suffering from a deficiency of the kidney and is regulated through the rational proportion to selected medical material according to the medical knowledge of traditional medicine " warming and recuperating the kidney-YANG nourishes kidney yin ", reaches therapeutic purposes.
With above-mentioned 8 flavor medicines is basic recipe, and this Tibetan medicine composite formula can also be expanded optimization, to strengthen drug effect.Specifically be also to contain 30～50 parts of Semen Granati, 28～50 parts on Flos Carthami, 1～5 part of Cordyceps, 20～50 parts of Rhizoma Gymnadeniaes, 14～30 parts in Rhizoma Gastrodiae.
Semen Granati is recorded in " first of the Sanitation Ministry medicine standard Tibetan medicine " (standard numbering WS3-BC-0026-95, Tibetan medicine title: match Zhu), be Punicaceae plant pomegranate (Punica granatum L.) dry seed.Cure mainly Baconic's sympotoms caused by cold factors, cold syndrome of the stomach disease and all gastropathy.
Flos Carthami, the another name Flos Carthami is the tubular flower of dicotyledon medicine feverfew Flos Carthami (Carthamus tinctorius L.).Main effect be to invigorate blood circulation latus rectum, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury.
Cordyceps has another name called Cordyceps, Cordyceps, Cordyceps sinensis.Be that section ergot fungus cordyceps sinensis bacterium (Cordyceps sinensis) colonizes in Stroma and the larva cadaveric complex on Hepialidae insecticide Vespertilio moth (the Hepialus armoricanus Oberthur) larva that survives the winter.Return lung, kidney channel.Main effect is invigorating the lung and the kidney, hemostasis and phlegm.Be used for the chronic cough dyspnea due to deficiency, the chronic cough spitting of blood, impotence and seminal emission, soreness of waist and knee joint is the famousst and precious strengthening by means of tonics medicine that has won fame both at home and abroad.
Rhizoma Gymnadeniae is recorded in " Tibetan medicine is promulgated by the ministries or commissions of the Central Government " (standard No.: WS3-BC-0015-95, Tibetan language title: prosperous drawing); Have another name called Rhizoma Gymnadeniae; Be the dry tuber of orchid Rhizoma Gymnadeniae (Gymnadenia conopsea R.Br.), have the effect of benefiting vital QI and blood, promoting the production of body fluid to quench thirst, to cough and asthma due to lung deficiency, asthenia become thin, aspect such as neurasthenia has very high health preserving and is worth; Mainly edible on Tibet and other places as tonic, commonly usedly steep in wine, praise soup or boil.
Rhizoma Gastrodiae is the dry tuber of orchid Rhizoma Gastrodiae (Gastrodia elata Bl.).Rhizoma Gastrodiae embellishes but not dry, and the master goes into Liver Channel, is longer than suppressing the hyperactive liver to relieve the wind syndrome, and the disease of all liver-wind stirring up internallys, the vertigo is no matter deficiency and excess all is important medications.
The present invention also provides the application of above-mentioned Tibetan medicine compositions in preparation treatment kidney deficiency disease drug.
Tibetan medicine compositions provided by the invention comprises the insufficiency of kidney-YANG (triumphant plan disease) or the deficiency of the kidney yin (triumphant normal disease) of clinical diagnosis through the disease of suffering from a deficiency of the kidney that the clinical trial checking can be applied to prevent and treat multiple crowd.Particularly with have a delicate constitution, tired, the chronic problem of spirit, urine are not normal, alopecia, forgetful, sweating due to debility, insomnia, sexual hypofunction, urine urgency-frequency, premature ejaculation etc. serve as multiple crowd's kidney deficiency disease of showing disease.
The present invention also provides above-mentioned Tibetan medicine preparation of compositions method simultaneously, and concrete scheme is following:
Above-mentioned Tibetan medicine preparation of compositions method is characterized in that: each medical material component is disposed in proportion, according to traditional patent medicine processing method, add in case of necessity that acceptable auxiliary is prepared into different dosage form on the pharmaceutics.
Specific dosage forms for oral administration can be a variety of dosage forms such as capsules, powders, granules, pills, tablets, soups, creams, wine, molasses, oil cakes drugs, etc. You concentrated.
Compared with prior art, the invention has the beneficial effects as follows: tradition medical material common, commonly used is prepared from according to traditional Tibetan medicine concocting method in (1) this Tibetan medicine compositions employing Tibetan medicine and pharmacology, is that former medicine of medical material or method for preparing are all safe and reliable; (2) the Tibetan medicine compositions be applied to prevent and treat multiple crowd suffer from a deficiency of the kidney the disease drug effect significantly, short treating period, have no side effect.
Description of drawings
Fig. 1 is basic components capsule, powder preparation flow figure.
Fig. 2 is expansion optimization of C capsule, powder preparation flow figure.
Fig. 3 is basic components granule preparation flow figure.
Fig. 4 is expansion optimization of C granule preparation flow figure.
The specific embodiment
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are further described.
Embodiment one
As shown in Figure 1, the preparation of Tibetan medicine composition capsule dosage form.
Tibetan medicine composition component and weight proportion thereof are: 10～60 parts of Agama himalayana, 40～80 parts of Herba pleurospermi thomsoniis, 40～70 parts of Rhizoma Polygonatis, 40～60 parts of Himalaya Mirabilis jalapas, 40～70 parts of Fructus Tribulis, 40～60 parts of Radix Asparagi, 20～50 parts of Saussurea medusa Maxim., 20～40 parts in milk.
The following prepared of concrete employing:
Step S1, get Herba pleurospermi thomsonii, Himalaya Mirabilis jalapa, Fructus Tribuli, Rhizoma Polygonati, Radix Asparagi, Saussurea medusa Maxim. 6 flavor medical materials and adopt the decocting cooking methods to extract, extracting solution;
Amount of water is 11～13 times of medical material volume during decoction, decocts 100 ℃～107 ℃ of temperature; Decoct twice, each 3.5～4.5hr; It is subsequent use to get twice decoction extracting solution mixing.
Step S2, get step S1 gained extracting solution and add the milk mixing while hot and boil 20～40min altogether, boil liquid altogether and be concentrated into 0.8～1.0 ° of B é of Baume degrees, spray-dried again extract powder;
Milk is preferably fresh not skim milk.Extracting solution and milk boil for 88 ℃～105 ℃ altogether.
Step S3, get Agama himalayana and be processed as fine powder, with step 2 gained extract powder mixing, mixed powder.
The optimum condition of extract powder and Agama himalayana powder married operation is for to mix 30～40min in the 85rpm grinder-mixer.
Step S4, get step 3 gained mixed powder and cross 80 mesh sieves, sterilization, capsule charge 0.4g/ grain.
Disinfecting action is selected the ozone fumigation for use, and operating condition is density 1.68, circulation 2hr, arranges 18 ℃～26 ℃ of 2hr, temperature, humidity 45%～65% entirely.
Embodiment two
As shown in Figure 2, the preparation of Tibetan medicine composition capsule dosage form.
Tibetan medicine composition component and weight proportion thereof are: 10～60 parts of Agama himalayana, 40～80 parts of Herba pleurospermi thomsoniis, 40～70 parts of Rhizoma Polygonatis, 40～60 parts of Himalaya Mirabilis jalapas, 40～70 parts of Fructus Tribulis, 40～60 parts of Radix Asparagi, 20～50 parts of Saussurea medusa Maxim., 20～40 parts in milk, 30～50 parts of Semen Granati, 28～50 parts on Flos Carthami, 1～5 part of Cordyceps, 20～50 parts of Rhizoma Gymnadeniaes, 14～30 parts in Rhizoma Gastrodiae.
Step S1～step S2 is with embodiment one.
Step S3, get Agama himalayana, Semen Granati, Flos Carthami, Cordyceps, Rhizoma Gymnadeniae, Rhizoma Gastrodiae 6 flavor medical materials and be processed as fine powder, with step 2 gained extract powder mixing, mixed powder.
The optimum condition of extract powder and medical material fine powder married operation is for to mix 30～40min in the 85rpm grinder-mixer.
Step S4, get step 3 gained mixed powder and cross 80 mesh sieves, sterilization, capsule charge 0.4g/ grain.
Embodiment three
As shown in Figure 2, the preparation of Tibetan medicine compositions powder.
Tibetan medicine composition component and weight proportion thereof are with embodiment two.
Step S1～step S3 is with embodiment two.
Step S4, get step 3 gained mixed powder and cross 80 mesh sieves, sterilization, packing.
Embodiment four
As shown in Figure 3, the preparation of Tibetan medicine composition grain dosage form.
Tibetan medicine composition component and weight proportion thereof are with embodiment one.
Step S1, get Herba pleurospermi thomsonii, Rhizoma Polygonati, Himalaya Mirabilis jalapa, Fructus Tribuli, Radix Asparagi, Saussurea medusa Maxim. 6 flavor Tibetan medicine materials according to formula proportion and adopt the decocte with water methods to extract, extracting solution.
Amount of water is 11～13 times of medical material volume during decoction, decocts 100 ℃～107 ℃ of temperature; Decoct twice, each 3.5～4.5hr; It is subsequent use to get twice decoction extracting solution mixing.
Step S2, get step S1 gained extracting solution and add the milk mixing while hot and boil 20～40min altogether, boil liquid altogether and be concentrated into 0.8～1.0 ° of B é of Baume degrees, spray-dried again extract powder.
Milk is preferably fresh not skim milk.Extracting solution and milk boil for 88 ℃～105 ℃ altogether.
Step S3, get Agama himalayana and be processed as fine powder, with step 2 gained extract powder mixing, mixed powder.
The optimum condition of extract powder and Agama himalayana powder married operation is for to mix 30～40min in the 85rpm grinder-mixer.
Step S4, get step S3 gained mixed powder and cross 80 mesh sieves, according to medicated powder: water (W/W)=ratio added water in 2: 1, granulate, drying, granulate is crossed 24 mesh sieves, sterilization, granule, packing.
Be excipient with water in this step.Dry moisture is controlled to be 2% according to conventional index.
Embodiment five
As shown in Figure 4, the preparation of Tibetan medicine composition grain dosage form.
Tibetan medicine composition component and weight proportion thereof are with embodiment two.
Step S1, get Herba pleurospermi thomsonii, Rhizoma Polygonati, Himalaya Mirabilis jalapa, Fructus Tribuli, Radix Asparagi, Saussurea medusa Maxim., Semen Granati, Flos Carthami, Cordyceps, Rhizoma Gymnadeniae, Rhizoma Gastrodiae 12 flavor Tibetan medicine materials according to formula proportion and adopt the decocte with water methods to extract, extracting solution.
Amount of water is 11～13 times of medical material volume during decoction, decocts 100 ℃～107 ℃ of temperature; Decoct twice, each 3.5～4.5hr; It is subsequent use to get twice decoction extracting solution mixing.
Step S2～step S4 is with embodiment four.
Embodiment six
The process of preparing Chinese medicine of Agama himalayana.
In the Tibetan medicine preparation of compositions method of above-mentioned each embodiment record, the concocting method of Agama himalayana can be improved, to strengthen its drug effect.Concrete grammar is: earlier Agama himalayana is put to death, remove internal organs, head, afterbody, clear water is cleaned, and bubble is gone into traditional highland barley wine; In barley wine, add Moschus, stir while adding, addition is for beginning to smell the Moschus flavor, and container is added a cover and soaked 8～10hr; Heating barley wine to 60 ℃～70 ℃ is cooled to 25 ℃～35 ℃, takes out Agama himalayana, and cold water is cleaned, and it is subsequent use to dry in the shade.
This Tibetan medicine compositions can be processed multiple peroral dosage form according to traditional Tibetan medicine processing method, is not limited to the technical scheme of above each embodiment record.
Test Example one
Embodiment one, four makes the Tibetan medicine compositions and processes the application of agent in disease is suffered from a deficiency of the kidney in treatment with prevention.Table 1 seen in sufferer diagnosis and treatment record.
Table 1 sufferer diagnosis and treatment records (13 example)
Test Example two
Embodiment two, three, five makes the Tibetan medicine compositions and processes the application of agent in disease is suffered from a deficiency of the kidney in treatment with prevention.
Table 2 seen in sufferer diagnosis and treatment record.Curative effect determinate standard is divided into reference to " new Chinese medicine clinical research guideline ": clinical recovery: the symptom of suffering from a deficiency of the kidney, sign disappear; Produce effects: the symptom of suffering from a deficiency of the kidney, sign are obviously improved; Effectively: the symptom of suffering from a deficiency of the kidney, sign all take a favorable turn, and be invalid: the symptom of suffering from a deficiency of the kidney, sign no change.Sufferer diagnosis and treatment curative effect statistics is seen table 3.
Table 2 sufferer diagnosis and treatment records (26 example)
The continuous table of going up
Table 3 sufferer diagnosis and treatment curative effect statistics (100 example)
| Clinical recovery | Produce effects | Effectively | Invalid | Amount to | |
| Sufferer number (example) | 10 | 30 | 50 | 10 | 100 |
| Curative effect ratio (%) | 10 | 30 | 50 | 10 | 100 |
Test Example one, two data show Tibetan medicine compositions of the present invention basic recipe and expansion optimization of C all can effectively be applied to prevent and treat the preparation of kidney deficiency disease drug.
Test Example three
The test of mixed powder measurement of water-content coefficient.
Each dosage form prepares the gained mixed powder and carries out the measurement of water-content coefficient test, and every kind of dosage form repeats 2 tests, and data record sees attached list 4.Each dosage form machines the preceding moisture content of packing capsule＜9.0%, powder moisture content＜9.0%, granule moisture content＜6.0%, all meets the NF standard.
Subordinate list 4 mixed powder moisture content
Annotate: the empty weighing botle weight of W1-; Empty weighing botle weight of W2-and medicated powder weight; Empty weighing botle and medicated powder weight after the W3-drying.
Claims (10)
1. a Tibetan medicine compositions is characterized in that: contain 10～60 parts of Agama himalayana, 40～80 parts of Herba pleurospermi thomsoniis, 40～70 parts of Rhizoma Polygonatis, 40～60 parts of Himalaya Mirabilis jalapas, 40～70 parts of Fructus Tribulis, 40～60 parts of Radix Asparagi, 20～50 parts of Saussurea medusa Maxim., 20～40 parts in milk.
2. Tibetan medicine compositions according to claim 1 is characterized in that: also contain 30～50 parts of Semen Granati, 28～50 parts on Flos Carthami, 1～5 part of Cordyceps, 20～50 parts of Rhizoma Gymnadeniaes, 14～30 parts in Rhizoma Gastrodiae.
3. Tibetan medicine preparation of compositions method according to claim 1 and 2 is characterized in that: each medical material component is disposed in proportion, according to traditional patent medicine processing method, add in case of necessity that acceptable auxiliary is prepared into different dosage form on the pharmaceutics.
4 according to the method of claim 3, wherein: said dosage forms include capsules, powders, granules, pills, tablets, decoction, ointment, tincture, syrup, oil cakes drugs, You concentrate.
5. method for preparing according to claim 3 is characterized in that: prepare according to one of following process:
Technology one: step S1 gets Herba pleurospermi thomsonii, Himalaya Mirabilis jalapa, Fructus Tribuli, Rhizoma Polygonati, Radix Asparagi, Saussurea medusa Maxim. 6 flavor medical materials employing decocting cooking methods extractions according to formula proportion, gets extracting solution; Step S2 gets step S1 gained extracting solution and adds the milk mixing and boil altogether, boils altogether that liquid concentrates, spray drying gets extract powder; Step 3 is got Agama himalayana and is processed as fine powder, with step 2 gained extract powder mixing, gets mixed powder; Step S4, step 3 gained mixed powder sieves, and sterilization makes powder or filling becomes capsule;
Technology two: step S1 gets Herba pleurospermi thomsonii, Himalaya Mirabilis jalapa, Fructus Tribuli, Rhizoma Polygonati, Radix Asparagi, Saussurea medusa Maxim. 6 flavor medical materials employing decocting cooking methods extractions according to formula proportion, gets extracting solution; Step S2 gets step S1 gained extracting solution and adds the milk mixing and boil altogether, boils altogether that liquid concentrates, spray drying gets extract powder; Step 3 is got Agama himalayana, Semen Granati, Flos Carthami, Cordyceps, Rhizoma Gymnadeniae, Rhizoma Gastrodiae 6 flavor medical materials and is processed as fine powder, gets mixed powder with step 2 gained extract powder mixing; Step S4, step 3 gained mixed powder sieves, and sterilization makes powder or filling becomes capsule;
Technology three: step S1, get Herba pleurospermi thomsonii, Rhizoma Polygonati, Himalaya Mirabilis jalapa, Fructus Tribuli, Radix Asparagi, Saussurea medusa Maxim. 6 flavor Tibetan medicine materials according to formula proportion and adopt the decocte with water methods to extract, extracting solution; Step S2 gets step S1 gained extracting solution and adds the milk mixing and boil altogether, boils altogether that liquid concentrates, spray drying gets extract powder; Step S3 gets Agama himalayana and is processed as fine powder, with step 2 gained extract powder mixing, gets mixed powder; Step S4, step S3 gained mixed powder sieves, and adding entry is excipient, granulate, drying, granulate sieves, and sterilization gets granule;
Technology four: step S1, get Herba pleurospermi thomsonii, Rhizoma Polygonati, Himalaya Mirabilis jalapa, Fructus Tribuli, Radix Asparagi, Saussurea medusa Maxim., Semen Granati, Flos Carthami, Cordyceps, Rhizoma Gymnadeniae, Rhizoma Gastrodiae 12 flavor Tibetan medicine materials according to formula proportion and adopt the decocte with water methods to extract, extracting solution; Step S2 gets step S1 gained extracting solution and adds the milk mixing and boil altogether, boils altogether that liquid concentrates, spray drying gets extract powder; Step S3 gets Agama himalayana and is processed as fine powder, with step 2 gained extract powder mixing, gets mixed powder; Step S4, step S3 gained mixed powder sieves, and adding entry is excipient, granulate, drying, granulate sieves, and sterilization gets granule.
6. method according to claim 5 is characterized in that: among the said step S2, extracting solution adds fresh not skim milk mixing, and 88 ℃～105 ℃ are boiled 20～40min altogether, boil liquid altogether and are concentrated into 0.8～1.0 ° of B é of Baume degrees, the spray-dried again extract powder that gets; Said step 3 extract powder is in the 85rpm grinder-mixer, to mix 30～40min with medicated powder married operation condition; Said disinfecting action is the ozone fumigation, and operating condition is density 1.68, circulation 2hr, arranges 18 ℃～26 ℃ of 2hr, temperature, humidity 45%～65% entirely; In the said technology three or four, the excipient addition is a medicated powder: water (W/W)=2: 1.
7. according to claim 5 or 6 described methods, it is characterized in that: said Agama himalayana concocting method is: Agama himalayana is put to death, and removes internal organs, head, afterbody, cleans; Bubble is gone into traditional highland barley wine, in barley wine, adds Moschus, stirs while adding, and addition is for beginning to smell the Moschus flavor; Infusion 8～10hr, heating barley wine to 60 ℃～70 ℃ is cooled to 25 ℃～35 ℃; Take out Agama himalayana, cold water is cleaned, and it is subsequent use to dry in the shade.
8. the application of Tibetan medicine compositions according to claim 1 and 2 in preparation treatment kidney deficiency disease drug.
9. application according to claim 8 is characterized in that: deficiency of the kidney yin that the said disease of suffering from a deficiency of the kidney is clinical diagnosis or insufficiency of kidney-YANG disease.
10. application according to claim 9 is characterized in that: the said disease of suffering from a deficiency of the kidney be with have a delicate constitution, tired, the chronic problem of spirit, urine are not normal, alopecia, forgetful, sweating due to debility, insomnia, sexual hypofunction, urine urgency-frequency, premature ejaculation etc. serve as multiple crowd's kidney deficiency disease of showing disease.
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| CN103961565A (en) * | 2014-05-22 | 2014-08-06 | 卢祥平 | Externally-applied medicine for enhancing renal function |
| CN107714955A (en) * | 2017-11-14 | 2018-02-23 | 乡城藏青兰药业有限公司 | The concocting method of rhizoma Gastrodiae |
| CN111821379A (en) * | 2020-07-17 | 2020-10-27 | 西藏藏医药大学 | Preparation method of Tibetan medicine Basang mu ghee pill soft capsule for improving immunity |
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| CN1899565A (en) * | 2006-07-04 | 2007-01-24 | 洛嘎 | Morning oral administration Tibetan medicine for treating diabetes and its preparing method |
| CN1919225A (en) * | 2006-09-18 | 2007-02-28 | 中国人民解放军军事医学科学院生物工程研究所 | Application of cultured saussurea medusa and extract thereof in preparation of medicine for treating II type diabetes and its complications |
| CN102366540A (en) * | 2011-09-28 | 2012-03-07 | 久美彭措 | Medicine for treating diabetes and its preparation method |
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| CN1899565A (en) * | 2006-07-04 | 2007-01-24 | 洛嘎 | Morning oral administration Tibetan medicine for treating diabetes and its preparing method |
| CN1919225A (en) * | 2006-09-18 | 2007-02-28 | 中国人民解放军军事医学科学院生物工程研究所 | Application of cultured saussurea medusa and extract thereof in preparation of medicine for treating II type diabetes and its complications |
| CN102366540A (en) * | 2011-09-28 | 2012-03-07 | 久美彭措 | Medicine for treating diabetes and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103961565A (en) * | 2014-05-22 | 2014-08-06 | 卢祥平 | Externally-applied medicine for enhancing renal function |
| CN107714955A (en) * | 2017-11-14 | 2018-02-23 | 乡城藏青兰药业有限公司 | The concocting method of rhizoma Gastrodiae |
| CN111821379A (en) * | 2020-07-17 | 2020-10-27 | 西藏藏医药大学 | Preparation method of Tibetan medicine Basang mu ghee pill soft capsule for improving immunity |
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Effective date of registration: 20151104 Address after: Lin Qionggang road Lhasa 851400 Tibet autonomous region economic and Technological Development Zone No. 15 Patentee after: TIBET GANLU TIBETAN MEDICINE CO., LTD. Address before: 850000, 23 hot road, Lhasa, Tibet Patentee before: Ci Wang |