CN104688855A - Coptidis rhizome and donkey-hide glue composition for the treatment of chronic fatigue syndrome and application thereof - Google Patents

Abstract

The invention discloses a coptidis rhizome and donkey-hide glue composition for the treatment of chronic fatigue syndrome and the application thereof, and belongs to traditional Chinese medicine field. Raw materials of the traditional Chinese medicine composition comprises coptidis rhizome, donkey-hide glue, white peony roots, radix scutellariae, spina date seeds, cinnamon and cortex albiziae. According to the coptidis rhizome and donkey-hide glue composition for the treatment of chronic fatigue syndrome and the application thereof, the effects of nourishing Yin and moistening dryness, clearing away heat and toxic materials and promoting blood circulation to remove blood stasis are possessed, the treatment effect on the chronic fatigue syndrome is obvious, the cure rate is 67.2%, the total effective rate is 96.9%, and the advantages of being good in treatment effect, short in treatment course and no side effect are possessed; the dispensation and making method are unique, and an outstanding effect is possessed on the prevention and treatment of the chronic fatigue syndrome.

Description

A kind of Chinese goldthread colla corii asini compositions and application thereof for the treatment of chronic fatigue syndrome

Technical field

The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese goldthread colla corii asini compositions and application thereof for the treatment of chronic fatigue syndrome.

Background technology

Chronic fatigue syndrome (chronic fatigue syndrome, CFS) be one group to continue or the fatigue of recurrent exerbation, with multiple nerve, mental symptom, but be the syndrome of feature without organic and psychotic disorder.U.S.'s disease prevention and control centre have established this disease the phase at the end of the eighties in last century, and the patient in the cities such as Japanese, American-European developed country and Hong Kong is more.The chief complaint of chronic fatigue syndrome is extremely tired for a long time, comprise mental fatigue and physical fatigue, patient often has the sensation of not having enough sleep, even if CBR is also failed to releive tired out, muscle power also can constantly decline, quantity of motion only reaches half at ordinary times, patient also there will be difficult to concentrate on, the problem such as memory is deteriorated, joint and myalgia, symptom can continue half a year or more, but physical examination and the many genus of blood test results of many patients are normal, also fail to find out the reason causing fatigue for a long time.Medical circle estimated pressure is one of major reason causing chronic fatigue syndrome.Rapidly, sickness rate is high for rhythm of life.The environmental factorss such as sultry, pollution, noise, compressing all may cause the nerve of human body, endocrine and immune system disorder, produce chronic fatigue syndrome thus.In daily life, due to reasons such as the anxiety that is busy with one's work, lives, learning burden are heavy, some can feel to tire out often, generally, the patient several days of self-induction fatigue or after one week muscle power can recover.If fatigue was more than one month, can think to continue fatigue; If fatigue symptom is longer than 3 months, just required hospital goes to a doctor in time.Half a year more than is continued if tired, and with myalgia, headache, low grade fever, absent minded, hypomnesis, depressed, Sleep hyperhidrosis, body weight change, throat aches, multiple arthralgia, even if Sufficient Sleeping, muscle power is still difficult to recover, Fatique after Sports sense continues the symptoms such as long period, even affect the work of people, study and daily life, just may suffer from fatigue syndrome or primary chronic fatigue.Many researcheres are thought, chronic fatigue syndrome is the symptom in advance entering " overworking death ".Because the primary disease course of disease is longer, generally more than half a year, the very then several years, have a strong impact on study and the work efficiency of patient.The research of chronic fatigue syndrome is become to the focus of 21 century medical circle concern and research, strengthened the research of alleviation and treatment chronic fatigue syndrome medicament and method significant.

The western medical treatment of chronic fatigue syndrome is based on supporting treatment of suiting the medicine to the illness, and have anti depressant therapy, antiviral therapy, immunization therapy, nutritional supplementation and the therapy such as megavitamin, psychological counselling, its curative effect major part is not yet determined.At present, doctor trained in Western medicine lacks specific treatment means to CFS, and domestic report adopts this disease of traditional Chinese medical herbal treatment to obtain good therapeutic effect.But the traditional Chinese medical science is to the many experiences according to doctor of CFS differentiation of symptoms and signs for classification of syndrome, and Syndrome Types of TCM is comparatively chaotic, affects the evaluation of traditional Chinese medical herbal treatment CFS curative effect.The Chinese medicine preparation listing of the treatment chronic fatigue syndrome being also of no curative effect definite in the market.

Summary of the invention

The invention provides a kind of successful, effective percentage is high, the Chinese goldthread colla corii asini compositions of the treatment chronic fatigue syndrome that side effect is little and application thereof.

The present invention is achieved by the following technical solutions:

Treat a Chinese goldthread colla corii asini compositions for chronic fatigue syndrome, it is characterized in that being made up of each crude drug of following weight portion: Rhizoma Coptidis 6-10 part, Colla Corii Asini 7-12 part, Radix Paeoniae Alba 4-8 part, Radix Scutellariae 1-5 part, Semen Ziziphi Spinosae 4-8 part, Cortex Cinnamomi 0.5-4 part and Cortex Albiziae 4-8 part.

Preferably, described compositions, is characterized in that, the weight portion of each crude drug is: Rhizoma Coptidis 8 parts, 9 parts, Colla Corii Asini, the Radix Paeoniae Alba 6 parts, Radix Scutellariae 3 parts, Semen Ziziphi Spinosae 6 parts, Cortex Cinnamomi 2 parts, Cortex Albiziae 6 parts.

Further preferred, the Chinese goldthread colla corii asini compositions of described treatment chronic fatigue syndrome, is characterized in that: be prepared into preparation suitable clinically according to Chinese medicine preparation.Described preparation comprises capsule, pill, powder, granule, tablet, oral liquid or drop pill.

Preferably, the preparation method of described compositions, is characterized in that: take each crude drug by described weight portion; Each crude drug is pulverized, sieves, add the adjuvant needed for preparations shaping or excipient, be prepared into capsule, tablet or pill.

Further preferred, the preparation method of described compositions, is characterized in that comprising the following steps:

(1) each crude drug is taken by described weight portion;

(2) Cortex Cinnamomi is extracted volatile oil, pulverize after inclusion essential oil, for subsequent use;

(3) the Cortex Cinnamomi medicinal residues after extraction volatile oil and Radix Scutellariae, Cortex Albiziae one are reinstated water extraction, by aqueous extract spraying dry, for subsequent use;

(4) by Rhizoma Coptidis, the Radix Paeoniae Alba and Semen Ziziphi Spinosae 30-85% ethanol extraction, by ethanol extract spraying dry, for subsequent use;

(5) mix homogeneously with the product that step (2), (3) and (4) obtain after Colla Corii Asini being pulverized, add pharmaceutical preparation auxiliary materials and mixing and make intermediate formulations, then make finished dosage form through preparations shaping technique.

Present invention also offers the application of described Chinese goldthread colla corii asini compositions in preparation treatment chronic fatigue syndrome medicament.

The syndrome that chronic fatigue syndrome is is principal character with debilitating fatigue, except with pharyngalgia, lymph node pain, myalgia, there is no the red and swollen symptom such as migrans arthralgia, headache except, also with the mental symptoms such as sleep disordered, depressed, anxiety and forgetful, the symptom such as difficult of focusing one's attention on.The main clinical manifestation of chronic fatigue syndrome can be summarized as several aspect such as confirmed fatigue, influenza-like symptom (low grade fever, pharyngalgia, headache, muscular soreness, arthralgia etc.), sleep disordered (insomnia, drowsiness or the sleep etc. of not recovering from fatigue), Cognitive function damage (short term memory infringement, difficulty etc. of focusing one's attention on, can be classified as mental fatigue), dysthymic disorder's (depression, anxiety, irritability, emotional instability etc.).

The present invention is the new indication of the treatment chronic fatigue syndrome of exploitation further on the basis of patent 200910128489. X.Prescribed treatment insomnia Be very effective of the present invention, this prescription is moved the treatment controlled and be used for the treatment of chronic fatigue syndrome, achieve beyond thought technique effect: clinical therapeutic efficacy is obvious, cure rate is 67.2%, total effective rate is 96.9%, Clinical practice safety, patient has no adverse reaction after using, and does not also produce any dependent reaction after medicine of the present invention of stopping using.

The morbidity of CFS mainly because body constitution weakness, being invaded by exogenous pathogen, feelings will are smooth, bother excessively, the heart that the reason such as eating and drinking without temperance causes, liver,spleen,kidney involved negative and positive of qi and blood imbalance and formed.The generation of primary disease mainly damages qi-blood-body fluid by pathogenic dryness and causes the loss of cloudy Tianjin, deficiency of qi and blood, histoorgan is lost and supports, and occurs muscle power and mental weakness, fatigue; Deficiency of YIN-blood, Yu Xue Bi hinders, and expectorant condensation is poly-, and venation is obstructed, causes limbs pain, and organ function is lacked of proper care, and makes body occur taediumvitae and other folder disease of holding concurrently.The present invention treats CFS pathogenesis and follows deficiency of YIN-blood, depletion of body fluid causing lack of blood, dry very removing toxic substances, based on nourshing Yin and drynsessmoistening prescription, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling during treatment.The present invention meets the pathogenesis of chronic fatigue syndrome completely.

The compatibility foundation of Chinese medicine composition of the present invention:

In side, Rhizoma Coptidis, Radix Scutellariae are monarch drug, heat-clearing and toxic substances removing, removing pathogen in the heart lung meridian excess-fire.Colla Corii Asini, the Radix Paeoniae Alba, nourishing kidney nourishing YIN, nourishing YIN and benefiting blood is ministerial drug.Cortex Albiziae resolving stagnation for tranquilization, blood circulation promoting and blood stasis dispelling, Semen Ziziphi Spinosae tonifying liver mind calming promotes the production of body fluid, and using corrigent Cortex Cinnamomi is supporing yang to mend fire, warming the meridian and promoting blood circulation, makes sun rise cloudy long, the effect that jointly playing promotes the production of body fluid moisturizes, this is just meeting what is called " kind nourishing YIN person, must treating YIN within YANG, then YIN matched with sufficient YANG making living things fully vivid "; Cortex Cinnamomi and Rhizoma Coptidis are share with restoring normal coordination between the heart and kidney, meet at kidney under can making heart-fire, can make again that kidney is waterborne meets at the heart; All medicines share, simultaneously using both cold and hot drugs, and reinforcing and reducing, with executing, are trembled with fear and do not injure one's stomach, and mend and do not grow greasy, playing nourshing Yin and drynsessmoistening prescription, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling merit altogether.

Cortex Cinnamomi: acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.Function cures mainly: complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower." herbal classic ": Your Majesty's gas cough with dyspnea, stagnation of QI sore throat tells suction, sharp joint, invigorating the spleen and replenishing QI." not Lu ": main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago, only saliva, cough ， Bi Weng: can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, without feared." Japan hanako materia medica ": control all pathogenic wind, mends five kinds of strain and seven kinds of impairment, logical nine orifices, sharp joint, benefit essence, improving eyesight, warm waist knee joint, and broken mass beside the umbilicus lump in the abdomen, repercussive blood, controls migratory arthralgia joint contracture, reuniting the fractured tendons and bones, granulation promoting meat." medicine origin ": mend the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels not enough, controls the cold and exterior deficiency spontaneous perspiration of heavy cold shoulder." curing mainly secret wanting ": ooze and let out, quench the thirst.Wang Haogu: mend the gate of vitality not enough, boosting source of fire for eliminating abundance of yin.

The Radix Paeoniae Alba: nature and flavor are bitter is cool.Enter liver, spleen channel.Effect clots absorbing, pain relieving, removing heat from blood, detumescence.Control the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle." herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." not Lu ": clear and coherent blood vessels, in slow, dispelling malignant blood, expelling extravasated blood, anhydrate gas, sharp bladder intestine and small intestine, subduing inflammation, time row cold and heat, attacked by pestiferous factors is suffered from abdominal pain, lumbago." the southern regions of the Yunnan Province book on Chinese herbal medicine ": purgation of spleen excess fire, sending down the abnormal ascending QI, promoting the circulation of blood, removing blood stasis with potent drugs, loose clot, only stomachache, moves back heat in blood, attacks carbuncle skin ulcer, control mange.

Rhizoma Coptidis: bitter in the mouth, cold in nature.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated." herbal classic ": main steam ophthalmalgia, the corner of the eyes hinders delacrimation, improving eyesight, and intestinal debates stomachache dysentery, swells and ache in married woman's the moon.Essentials of Matea Medica: control carbuncle skin ulcer scabies, alcoholism, fetal toxicosis.Except infantile malnutrition, kill ascarid.

Radix Scutellariae: cold in nature, bitter in the mouth.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement." herbal classic ": main all hot jaundice, intestinal Bleach, lets out profit, relieves oedema or abdominal distension through diuresis or purgation, and hematochezia closes, (controlling) malignant boil, and cellulitis is lost, acute scleritis." not Lu ": treat expectorant heat, pathogenic heat in the stomach, little angina abdominis, rapid digestion of food, sharp small intestinal, woman's blood closes, drenches dew hematochezia, abdominal pain in children." property of medicine opinion ": can control pyretic toxicity, hectic fever due to YIN-deficiency, alternate attack of chill and fever, the intestines and stomach is unfavorable, broken heap soil or fertilizer over and around the roots gas, controls five types of stranguria, makes us a surname freely, goes to joint unhappy, yearningly antipyretic, and control hot Fu Zhong Xu pain, trusted subordinate's heavily fortified point is swollen." the southern regions of the Yunnan Province book on Chinese herbal medicine ": up purte the white, descendingly rushes down bladder fire, (controlling) man five types of stranguria, woman's sudden onset of metrorrhagia, regulating menstruation heat clearing away, and tire has burning hot uneasiness, clear fetal heat in pregnancy, except the six channels excess-fire excess-heat.9. " detailed outline ": control the damp and hot headache of wind heat, renal mass burning pain, cough caused by pathogenic fire, consumptive lung disease larynx raw meat, allly loses blood." book on Chinese herbal medicine is just ": the fire of the clear part of the body cavity above the diaphragm housing the heart and lungs of withered person, expectorant promoting the circulation of QI, relieving asthma and cough, only loses blood, and moves back alternate attacks of chills and fever, and wind heat is damp and hot, headache, separates pestilence, moistening and cleaning throat, treats consumptive lung disease lung abscess, acute mastitis carbuncle on the back, the heat of flesh table of especially dispelling, therefore controls macule, scrofula, skin infection, acute conjunctivitis; The heat of the cool part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels of reality person, can remove bloody dysentery, heat stores bladder, the puckery pain of five types of stranguria, and large intestine closes knot, has blood in stool, leaks blood.

Colla Corii Asini: sweet in the mouth, property is put down.Return lung, liver, kidney channel.Function cures mainly: YIN nourishing of enriching blood, and moisturizes, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy." herbal classic ": collapse in main trusted subordinate, the extremely voluminous symptoms like malaria of labor, waist is suffered from abdominal pain, painful limbs, woman's hematochezia.Antiabortive.Take QI invigorating for a long time." property of medicine opinion ": main hard muscles and bones, QI invigorating dysentery relieving." a thousand pieces of gold dietetic therapy ": control strong wind." Japan hanako materia medica ": control a wind cutting, and serious epistaxis, haematemesis, hemorrhoidal hamorrhage, dysentery and metrorrhagia leukorrhagia." detailed outline is picked up any lost article from the road ": control lumbago caused by internal damage, brute force stretches muscle, adds essence and reinforces the kidney.

Cortex Albiziae: property is put down, sweet in the mouth.GUIXIN, liver, lung meridian.Function cures mainly: resolving stagnation for tranquilization, promoting blood circulation and detumescence.For irritability, melancholy insomnia, lung abscess skin ulcer swells, and falls and flutters the pain of injury." herbal classic ": main settling five organs, and will, makes us happy carefree." Japan hanako materia medica ": soft extracts, subduing inflammation reuniting the fractured tendons and bones." detailed outline ": and blood, detumescence, pain relieving.

Semen Ziziphi Spinosae: property is put down, sweet in the mouth, acid.Return liver, gallbladder, heart channel.Function cures mainly: tonifying liver, mind calming, and arresting sweating promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty." herbal classic ": main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen." not Lu ": main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong." property of medicine opinion ": main muscles and bones wind, fries end and takes it as soup.Wang Haogu: control milk-livered sleeplessness, trembles with fear also, fries clothes; Control somnolence due to gallbladder-excess, heat also, use by life." book on Chinese herbal medicine converges and says ": astringing QI is calmed the nerves, and flourish muscle supports marrow, stomach function regulating activating the spleen." book on Chinese herbal medicine is new again ": suppressing the hyperactive liver is regulated the flow of vital energy, nourishing lung-YIN, warming middle-JIAO dampness removing, astringing QI hidroschesis, beneficial will is breathed out surely, hearing-improing and eyesight improving.

The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factor such as age, health status of concrete dosage form, patient.As guidance: usage and dosage: capsule, oral 5 at every turn, three times on the one.

Detailed description of the invention

Below in conjunction with embodiment, the present invention is further described.

embodiment 1: the preparation of capsule

(1) each raw material is taken by following weight: Rhizoma Coptidis 800g, Colla Corii Asini 900g, Radix Paeoniae Alba 600g, Radix Scutellariae 300g, Semen Ziziphi Spinosae 600g, Cortex Cinnamomi 200g, Cortex Albiziae 600g;

(2) Cortex Cinnamomi is extracted volatile oil, pulverize after inclusion essential oil, for subsequent use;

(3) the Cortex Cinnamomi medicinal residues after extraction volatile oil and Radix Scutellariae, Cortex Albiziae one are reinstated water extraction secondary, add water 2 times of weight for the first time, decocts 3 hours, and add water 4 times of weight for the second time, decocts 1 hour; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 DEG C); Merge twice clear paste, spraying dry, for subsequent use;

(4) by Rhizoma Coptidis, the Radix Paeoniae Alba and Semen Ziziphi Spinosae 85% ethanol extraction, extracting solution concentrates spraying dry after ethanol, for subsequent use;

(5) mix homogeneously with the product that step (2), (3) and (4) obtain after being pulverized by Colla Corii Asini, add appropriate lactose, mixing, dry-pressing becomes granule, incapsulates, and to obtain final product.

embodiment 2: the preparation of capsule

Prescription forms:

Rhizoma Coptidis 280g Colla Corii Asini 315g Radix Paeoniae Alba 210g Radix Scutellariae 105g

Semen Ziziphi Spinosae (stir-fry) 210g Cortex Cinnamomi 70g Cortex Albiziae 210g

Preparation technology:

(1) Rhizoma Coptidis, the Radix Paeoniae Alba, Semen Ziziphi Spinosae add 70% ethanol 6 times amount and extract 3 times, each 1.5 hours, and filter, filtrate recycling ethanol, is concentrated into relative density 1.08 ~ 1.10(60 DEG C), it is for subsequent use that spraying dry obtains fine powder;

(2) Cortex Cinnamomi adds water 12 times amount, soaks and extracts volatile oil 3.5 hours after 3 hours, and volatile oil, Aqueous extracts are placed for subsequent use, and medicinal residues are separately deposited for subsequent use; After getting the ethanol mixing adding 20% of beta-schardinger dextrin-3 times amount after Cortex Cinnamomi volatile oil adds the beta-schardinger dextrin-of 10 times amount again, filter after 24 hours with colloid mill cold preservation in 15 minutes of milling, the clathrate after filtration 40 DEG C oven dry, pulverize for subsequent use;

(3) Cortex Albiziae, Radix Scutellariae (dropping into after being heated to micro-boiling) and Cortex Cinnamomi medicinal residues, 6 times amount that add water extract 3 times, each 1 hour, and filter, filtrate is concentrated into relative density 1.08 ~ 1.10(60 DEG C), it is for subsequent use that spraying dry obtains fine powder;

(4) granulate after getting alcohol extract spraying dry fine powder, Aqueous extracts spraying dry fine powder, Benexate Hydrochloride, the mixing of Colla Corii Asini powder, granule is encapsulated, obtained 1000, to obtain final product.

embodiment 3:the preparation of powder

Each crude drug is taken: Rhizoma Coptidis 600g, Colla Corii Asini 700g, Radix Paeoniae Alba 400g, Radix Scutellariae 100g, Semen Ziziphi Spinosae 400g, Cortex Cinnamomi 50g, Cortex Albiziae 400g by following weight; After above-mentioned each crude drug is pulverized, cross 80 mesh sieves, to obtain final product.

embodiment 4:the preparation of granule

(1) each raw material is taken by following weight: Rhizoma Coptidis 1000g, Colla Corii Asini 1200g, Radix Paeoniae Alba 800g, Radix Scutellariae 500g, Semen Ziziphi Spinosae 800g, Cortex Cinnamomi 400g, Cortex Albiziae 800g;

(2) Cortex Cinnamomi is extracted volatile oil, pulverize after inclusion essential oil, for subsequent use;

(3) the Cortex Cinnamomi medicinal residues after extraction volatile oil and Radix Scutellariae, Cortex Albiziae one are reinstated water extraction secondary, add water 2 times of weight for the first time, decocts 3 hours, and add water 4 times of weight for the second time, decocts 1 hour; Decoction liquor merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 DEG C); Merge twice clear paste, spraying dry, for subsequent use;

(4) by Rhizoma Coptidis, the Radix Paeoniae Alba and Semen Ziziphi Spinosae 50% ethanol extraction, extracting solution spraying dry, for subsequent use;

(5) mix homogeneously with the product that step (2), (3) and (4) obtain after Colla Corii Asini being pulverized, add dextrin, stevioside, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, subpackage, to obtain final product.

embodiment 5: clinical research is tested

One, clinical data

1, physical data:

Be all out-patient, wherein male 25 example, women 39 example; 26 ~ 52 years old age, average 43.7 years old; The course of disease 6 months ~ 4.5 years.Diagnosis is with reference to the diagnostic criteria of the chronic fatigue syndrome (CFS) revised the Center for Disease Control (CDC) in November, 1994.Chinese medical discrimination foundation: hypomnesis or attention are not easy to concentrate, block up if any thing in pharynx, that tells does not go out, pharynx not under, difficulty falling asleep, easily wake up or early awakening, dream is many, time send out headache or dizzy, mood is irritated, spiritlessness and weakness, and conscious normal work is difficult to be competent at, red tongue or red tip of the tongue, tongue fur BOHUANG or greasy, stringy pulse or stringy and rolling pulse.Clinical various physical examination and laboratory examination results are negative.

Two, trial drug

Capsule prepared by the embodiment of the present invention 2.

Three, Therapeutic Method

Capsule prepared by embodiment 1: oral, one time 5,3 times on the one 7 days is a course for the treatment of, altogether treat 3 courses for the treatment of.All to stop using during patient treatment other oral and medicine for external use and be simultaneously careful in one's diet light.

Three, observation of curative effect

Because the CFS cause of disease and pathogenesis there is no final conclusion at present, how to improve situation according to clinical symptoms and sign and judge curative effect.

Recovery from illness: fatigue symptom disappears, work is normal with study, and spirit takes a turn for the better, and happy, each side is substantially as usual, follows up a case by regular visits to and does not recur half a year.

Effective: feeling of fatigue is obviously alleviated, emotion is basicly stable, disease improvement of holding concurrently, but still not resistance to fatigue, meets the environmental stimuli state of an illness easily repeatedly;

Invalid: symptom is not improved.

Four, therapeutic outcome

Carry out therapeutic evaluation according to curative effect judging standard, the results are shown in Table 1.

Table 1 clinical treatment outcome table of the present invention

Group	Number of cases	Recovery from illness	Effectively	Invalid	Effective percentage (%)
						Treatment group	64	43(67.2)	19(29.7)	3(3.1)	96.9%

Treatment group is totally 64 examples, and 43 examples of wherein fully recovering, account for 67.2%; Effective 19 examples, account for 29.7%; Invalid 3 examples, account for 3.1%, total effective rate is 96.9%.64 routine chronic fatigue syndrome patients of clinical observation, did not all use immunoglobulin therapy.The rule of clinical symptom remission, alleviating the fastest is sleep disorder, pharyngalgia and cervical pain, and being secondly that debilitating fatigue and muscle weakness alleviate, is finally the continuous improvement of attention and ability of thinking.The chemical examination monitorings such as routine blood test, routine urinalysis, stool routine, liver function and the renal function of patient after treatment, there is ANOMALOUS VARIATIONS in none example, compositions of the present invention is not only effective, and without toxicity, use safety.

embodiment 6: model case

Patient, man, 38 years old, go to a doctor in June, 2014, patient main suit was over the past half year, conscious fatigue and weak, soreness of the waist and knees, double see drowsiness, middle dreaminess of sleeping, diet is dull, large loose stool, the red white and thin fur of the tip of the tongue color, stringy and thready pulse, through many places examination in hospital, does not all find organic disease.Western medicine diagnose is chronic fatigue syndrome, multi-treatment poor effect, and patient requests takes capsule of the present invention 25 days, and clinical symptoms disappears completely, within 3 months, follows up a case by regular visits to without recurrence.

Claims (7)

1. treat a Chinese goldthread colla corii asini compositions for chronic fatigue syndrome, it is characterized in that being made up of each crude drug of following weight portion: Rhizoma Coptidis 6-10 part, Colla Corii Asini 7-12 part, Radix Paeoniae Alba 4-8 part, Radix Scutellariae 1-5 part, Semen Ziziphi Spinosae 4-8 part, Cortex Cinnamomi 0.5-4 part and Cortex Albiziae 4-8 part.

2. according to compositions according to claim 1, it is characterized in that, the weight portion of each crude drug is: Rhizoma Coptidis 8 parts, 9 parts, Colla Corii Asini, the Radix Paeoniae Alba 6 parts, Radix Scutellariae 3 parts, Semen Ziziphi Spinosae 6 parts, Cortex Cinnamomi 2 parts, Cortex Albiziae 6 parts.

3. according to the compositions described in claim 1 or 2, it is characterized in that: be prepared into preparation suitable clinically according to Chinese medicine preparation.

4. according to compositions according to claim 3, it is characterized in that: described preparation comprises capsule, pill, powder, granule, tablet, oral liquid or drop pill.

5. a preparation method for the compositions described in claim 1 or 2, is characterized in that: take each crude drug by described weight portion; Each crude drug is pulverized, sieves, add the adjuvant needed for preparations shaping or excipient, be prepared into capsule, tablet or pill.

6. a preparation method for the compositions described in claim 1 or 2, is characterized in that comprising the following steps:

(1) each crude drug is taken by described weight portion;

(2) Cortex Cinnamomi is extracted volatile oil, pulverize after inclusion essential oil, for subsequent use;

(3) the Cortex Cinnamomi medicinal residues after extraction volatile oil and Radix Scutellariae, Cortex Albiziae one are reinstated water extraction, by aqueous extract spraying dry, for subsequent use; (4) by Rhizoma Coptidis, the Radix Paeoniae Alba and Semen Ziziphi Spinosae 30-85% ethanol extraction, ethanol extract is reclaimed spraying dry after ethanol, for subsequent use;

(5) mix homogeneously with the product that step (2), (3) and (4) obtain after Colla Corii Asini being pulverized, add pharmaceutical preparation auxiliary materials and mixing and make intermediate formulations, then make finished dosage form through preparations shaping technique.

7. the application of the compositions described in claim 1 or 2 in preparation treatment chronic fatigue syndrome medicament.