CN102772523B - Bitter glossy ganoderma composition for oncotherapy and preparation method of bitter glossy ganoderma composition - Google Patents
Bitter glossy ganoderma composition for oncotherapy and preparation method of bitter glossy ganoderma composition Download PDFInfo
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Abstract
The invention relates to a bitter glossy ganoderma composition for oncotherapy and a preparation method of the bitter glossy ganoderma composition. The composition is prepared by raw materials of 10-50 of glossy ganoderma, 10-100 of milkvetch roots, 10-100 of Indian buead, 10-100 of brittle falsepimpernel herbs, 10-100 of red-rooted salvia roots, 10-100 of barbated skullcup herbs, 10-100 of spreading hedyotis herbs, 10-100 of agrimonies, 10-100 of kudzuvine roots and the like. The invention further provides a plurality of methods of alcohol extraction, water extraction and alcohol precipitation, raw powder medicining and the like for preparing the bitter glossy ganoderma. The glossy ganoderma composition has anti-cancer, anti-tumor, anti-inflammatory, heat-clearing and detoxicating effects; and according to clinical and pharmacological pesticide effects and experiments, inhibition ratios of the glossy ganoderma composition on s180 sarcomas, H22 tumors and EL_4 lymphomas are 48.9%, 58.5% and 51.9% respectively, and an anti-inflammatory ratio of the glossy ganoderma composition is 65.0%.
Description
Technical field
The present invention relates to treating malignant tumor field, particularly a kind of bitter glossy ganoderma composition for oncotherapy and preparation method thereof.
Background technology
Cancer is the disease of serious threat human life health, chemotherapeutics is when acting on tumor cell, the normal human body cell cell rapidly of particularly growing is also had to obvious inhibition growth or killing action, cause human body to produce great toxic and side effects.Therefore, find have compared with powerful antitumor effect again the new drug of safety become the problem that the whole world is paid close attention to.The antitumor drug of plant origin has multiformity aspect chemical constitution, also has multiformity simultaneously aspect mechanism of action.Therefore, from plant, finding the anti-tumor active substance act on various target spots has huge potentiality, and finding this class plant amedica becomes antineoplastic agent study hotspot.
Summary of the invention
The invention provides a kind of employing natural herb plant amedica is raw material, has bitter glossy ganoderma composition of stronger broad spectrum anticancer effect, safety non-toxic and preparation method thereof.The object of the invention is to be achieved through the following technical solutions:
Bitter glossy ganoderma composition for oncotherapy of the present invention is to be prepared from by following weight parts raw material:
Ganoderma 10-50 Radix Astragali 10-100 Poria 10-100 Herba Linderniae Crustaceae 10-100
Radix Salviae Miltiorrhizae 10-100 Herba Portulacae Grandiflorae 10-100 Oldenlandia diffusa Roxb 10-100
Agrimony 10-100 Radix Puerariae 10-100.
Bitter glossy ganoderma composition of the present invention, preferred parts by weight of raw materials consists of:
Ganoderma 20-40 Radix Astragali 30-70 Poria 30-70 Herba Linderniae Crustaceae 30-70
Radix Salviae Miltiorrhizae 30-70 Herba Portulacae Grandiflorae 30-70 Oldenlandia diffusa Roxb 30-70
Agrimony 30-70 Radix Puerariae 30-70.
Bitter glossy ganoderma composition of the present invention, the weight portion of optimum raw material consists of:
Ganoderma 30 Radix Astragali 50 Poria 50 Herba Linderniae Crustaceae 50 Radix Salviae Miltiorrhizaes 50
Herba Portulacae Grandiflorae 50 Oldenlandia diffusa Roxb 50 Agrimony 50 Radix Puerariaes 50.
The preparation method that the present invention also provides alcohol extraction, water extract-alcohol precipitation, former powder the multiple bitter glossy ganoderma composition such as to be used as medicine; inventor points out; the conventional pharmaceutical technology of any employing is also used the method for making of the simple change of raw material of Chinese medicine of the present invention, all within protection scope of the present invention.
The preparation method of a kind of bitter glossy ganoderma composition provided by the invention is: get raw material described in each, be ground into coarse powder, after soak with ethanol with 65%-85%, heating and refluxing extraction 2-6 hour, filters, filtrate recycling ethanol is tasteless to alcohol, mix with medicinal residues, mixed liquor decocts with water 2-6 hour, filters, filtrate is condensed into fluid extract, obtains bitter glossy ganoderma composition.
The preparation method of another bitter glossy ganoderma composition provided by the invention is: get raw material described in each, the 1-2 hour that is soaked in water, then decocts 3-5 time with 6-10 times of water gaging, and each 20-30 minute merges after filtering each decoction liquor, concentrates and to obtain concentrated solution; Concentrated solution is added to ethanol and carry out precipitate with ethanol, filter, filtrate recycling ethanol to without alcohol taste, is reclaimed to liquid again after fine straining, sterilizing, obtain bitter glossy ganoderma composition.
Particularly point out, in bitter glossy ganoderma composition of the present invention, contain iridoid glycoside 0.1%-3%.
Bitter glossy ganoderma composition of the present invention can be made various dosage forms with appropriate pharmacy adjuvant, includes but not limited to capsule, powder, tablet or injection.
The method for making that the invention provides a kind of capsule is: get above-mentioned 9 kinds of raw materials, after mixing, dry and porphyrize, crosses 80-120 mesh sieve 3-4 time, and sterilizing, is respectively charged into capsule by 0.25g, 5g, 1g various dose.
Bitter glossy ganoderma composition of the present invention is except for tumor, also for sterilization or antiinflammatory.
2, bitter glossy ganoderma composition of the present invention is to be derived from tcm family (Xie Shi family) proved recipe handed down from one's ancestors, through clinical research with great concentration in more than 60 years, and constantly improves and forms.
Clothes for patients is with just having significant reaction the same day, and as pain relief, vomiting number of times reduces, and has appetite sense; Take and within 2-3 days, just can improve the pain that produces and side effect in operation or Radiotherapy chemotherapy (as pain, insomnia, feel sick, vomiting, alopecia, leukopenia, pharynx food difficulty, weak tired etc.) and obviously alleviate and disappear, and can effectively strengthen patient's appetite, hypnotic, inspire enthusiasm, regain one's strength.Patient is being put, and before chemotherapy or in radiotherapy, starts to take continuously bitter glossy ganoderma composition, can improve in patient body Radiotherapy chemotherapy number of times, reduces treatment mortality rate critical days; Patient takes bitter Ganoderma for a long time continuously, can reduce transfer, the recurrence probability of cancerous cell.The cancer patient that early discovery is not suitable for operation, can control PD after taking, and prevents cancer cell metastasis, diffusion.Severe patients with advanced cancer, taking bitter glossy ganoderma composition can palliate the agonizing sufferings, and extends life cycle, improves life quality.Also there is patient with advanced cancer greatly disappear completely or obviously dwindle by large dose oral administration tumor, can normally work and live.
Raw material of Chinese medicine of the present invention is:
The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongho-licus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.
Herba Scutellariae Barbatae: be the dry herb of labiate Herba Scutellariae Barbatae Scutellaria barbata D.Don.Heat-clearing and toxic substances removing, blood stasis dispelling diuresis.
Herba Hedyotidis Diffusae: this product is the dry herb of Maguireothamnus speciosus Herba Hedyotidis Diffusae Hedyotis diffusa Willd..Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, inducing diuresis to remove edema.
Radix Puerariae: be the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi or Radix Puerariae rattan Pueraria thomsoniiBenth..Expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.
Agrimony: be the young stem and leaf of rosaceous plant Agrimony (Agrimonia pilosa Ledeb).Astringing to arrest bleeding, dysentery relieving, parasite killing.
Herba Linderniae Crustaceae: be goatweed Herba Linderniae Crustaceae Lindernia crustacea (L.) F.Muell, mildly bitter flavor, cool in nature.Function heat-clearing and toxic substances removing, inducing diuresis and reducing edema.
Beneficial effect of the present invention is, the effect such as that bitter glossy ganoderma composition has is anticancer, tumor suppression, antiinflammatory, heat clearing away toxin expelling, particularly can effectively prevent and suppress tumor.Its anticancer spectrum is wide, the early metaphase that is applicable to hepatocarcinoma, pulmonary carcinoma, esophageal carcinoma, nasopharyngeal carcinoma, intestinal cancer, the brain cancer, breast carcinoma, cervical cancer, cancer of pancreas, renal carcinoma, malignant lymphoma, leukemia, ovarian cancer, thyroid carcinoma, laryngeal carcinoma etc. suppresses, alleviation in late period is controlled symptom extending life, improved the quality of living, perioperatively auxiliary therapeutic action etc.The proofs such as clinical and pharmacological effect, experiment, are 48.9% to s180 sarcoma suppression ratio, and H22 tumor suppression ratio is 58.5%, and EL_4 lymphoma suppression ratio is 51.9%, and antiinflammatory rate is 65.0%, and adenocarcinoma of lung tumour inhibiting rate is 32.2%.Bitter glossy ganoderma composition has following characteristics:
1, elimination tumor is fast, and cleaning blood residual cancer cell is fast, and mutation is fast, improves physiological environment fast, and enhancing immunity is fast, removes pain fast;
2, do not rely on operation, chemicotherapy or other cancer therapy drugs, take separately and can obtain definite rehabilitation efficacy;
3, significant dose-effect relationship, middle and advanced stage and critical tumour patient escalated dose can accelerate to improve the speed of symptom;
4, long-term taking, can thoroughly clear up the residual cancer cell in blood, diffusion and the transfer of containment cancerous cell;
5, regulate human body organ function comprehensively, improve immune state, effectively protect internal organs not to be etched, improve anti-tumor capacity;
6, combined surgery, chemicotherapy, significantly efficacy enhancing and toxicity reducing, raising curative effect, suppress the appearance of various toxicities;
7, before and after early, middle and late phase tumour patient and operation, chemicotherapy, all can take;
8, composition is natural, manually cannot synthesize long-term taking safe without toxic side effect; No dependence.
9, Healthy People is taken by health care amount, can effectively prevent normal cell sudden change, and prophylaxis of tumours occurs.
In addition, bitter glossy ganoderma composition of the present invention also has the antibacterial action of penicillin, gently changes the antiinflammatory of cortisone, the effect of sterilization.
Below by test example, effect of the present invention is described further:
The bitter Ganoderma of test example 1 is antibacterial, antiinflammatory, tumor-inhibiting action experimentation
1, experiment material
1.1 measuring units: Traditional Chinese Medicine Research Institute, Sichuan Province
1.2 tested medicines: bitter glossy ganoderma composition is yellowish-brown granule, face the used time to be made into desired concn with distilled water.(tested medicine is provided by Xie Yu).Hydrocortisone (HC): 25mg/5ml, the accurate word H61021633 of traditional Chinese medicines, lot number 050226, Xi'an Lijun pharmaceutical Co., Ltd.Cyclophosphamide (CY): 200mg/ props up, the accurate word (1995) of medicine is defended No. 012034 in Shanghai, lot number 050503, Hualian Pharmaceutical Co., Ltd., Shanghai.Dimethylbenzene: AR, lot number 051047, Chengdu Ke Long chemical reagent factory.
1.3 S180 tumor strains: provided by Shanghai Institute of Pharmaceutical Industry.
1.4 animals: Kunming mouse: one-level animal, credit number: SCXK(river) No. 2003-02, provided by Animal Experimental Study chamber, Traditional Chinese Medicine Research Institute, Sichuan Province.Experimental situation: the medical experiment animal environment facility certificate of competency: No. 24103117th, the moving word of doctor, room temperature: 19-22 ℃, relative humidity: 45-70%.
2, method and result
2.1 bacteriostasis-extracorporeal bacteria inhibitor test
With coubling dilution, inoculation bacterium liquid 0.05ml, puts 37 ℃ of incubator 24h observed results.The minimum inhibitory concentration (MIC) that the lowest drug concentration of complete bacteria growing inhibiting of take is this medicine.Separately establish that to add after medicine the not test tube of inoculated bacteria be medicine contrast, the test tube that does not add medicine inoculated bacteria is antibacterial contrast.The results are shown in Table 1.
The lowest bacteria fogging-resistant concentration determining of the bitter Ganoderma of table 1 (MIC)
Table 1 result is visible, and bitter glossy ganoderma composition all has certain inhibitory action to streptococcus pneumoniae, staphylococcus aureus, escherichia coli, paratyphoid bacillus A, dysentery bacterium and bacillus pyocyaneus.
2.2 antiinflammatory actions---dimethylbenzene Mus auricle edema method
Get 50 of Kunming mouses, entirely male, body weight 20-25g, is divided into 5 groups immediately by body weight, and grouping and dosage are in Table 2, and every day, gastric infusion was 2 times, continuous 2 days.After last administration, the wide melted paraxylene 20ul of each Mus auris dextra of 40min causes inflammation (positive drug hydrocortisone is administered once, after administered intramuscular, 20min causes inflammation with method), cause after scorching 30min, de-cervical vertebra is put to death mice, with 8mm diameter card punch, laying ears sheet weighs, calculate and respectively organize Mus ear swelling degree, with t check, carry out statistical procedures.
Ear swelling degree (mg)=auris dextra sheet heavy (mg)-left auricle heavy (mg)
The bitter Ganoderma xylol of table 2 causes the impact of mice auricle swelling
Note: " * " represents to compare P<0.05 with blank group, and " * * " represents P<0.01, and " * * * " represents P<0.001.Lower same.
From table 2, the large, medium and small dosage group of bitter Ganoderma and blank group comparison xylol cause ear swelling all obvious inhibitory action (P<0.001, P<0.01, P<0.05).
2.3. tumor-inhibiting action---the inhibitory action to mouse S 180 sarcoma
Get and be inoculated in the kunming mice S180 sarcoma of 10 days, aseptic condition is rejected peplos and downright bad part, chooses intact tumor piece, puts in glass bacterium slurry device, adds 1:3 normal saline to be made into tumor cell suspension, every mice right fore axil subcutaneous injection 0.2ml.After inoculation, 24h is by animal (40 of Kunming mouses, entirely male, body weight 20-25g) by body weight random packet and start gastric infusion, and grouping and dosage are in Table 3.Every day gastric infusion once, continuous 10 days, experiment finished to weigh, and cutd open to get each treated animal tumor and weigh, tumor is reused t check and is carried out statistical procedures, and calculates inhibition rate of tumor growth.
The impact of the bitter Ganoderma of table 3 on S 180 Growth on Mice
Experimental result, bitter glossy ganoderma composition 4g/kg tumor is heavy relatively has significant difference (P<0.05) with matched group, and tumour inhibiting rate is 31.0%, shows that bitter Ganoderma can obviously suppress the growth of mouse S 180 sarcoma.
3. brief summary
Extracorporeal bacteria inhibitor test result shows, bitter glossy ganoderma composition all has bacteriostasis in various degree to staphylococcus aureus, streptococcus pneumoniae, escherichia coli, bacillus pyocyaneus, paratyphoid bacillus A, dysentery bacterium; Bitter Ganoderma can obviously suppress mice auricle swelling, points out it to have the acutely inflamed effect of inhibition; Can obviously suppress S 180 Growth on Mice.
Test example 2 EL_4 lymphoma, H22 tumor
Method: will clean level ICR male mice and be divided at random 4 groups by body weight, set up hepatocarcinoma H22 subcutaneous transplantation tumor model and EL_4 lymphoma model, be divided into normal saline matched group (con), high dose group (t3), middle dosage group (t2) and low dose group (t1).
Result: in the H22 tumor test of bitter glossy ganoderma composition, basic, normal, high group of tumour inhibiting rate is respectively 41.1%, 44.2% and 58.5%; With matched group comparison, body weight, the tumor index such as heavily change and all have statistical significance (P < 0.05); Liver, spleen are organized the aspect no difference of science of statistics (P > 0.05) such as organ index variation.
In the EL_4 lymphoma test of bitter glossy ganoderma composition, basic, normal, high group of tumour inhibiting rate is respectively 37.6%, 43.6% and 51.9%; With matched group comparison, body weight, the tumor index such as heavily change and all have statistical significance (P < 0.05); Liver, spleen are organized the aspect no difference of science of statistics (P > 0.05) such as organ index variation
Conclusion: bitter glossy ganoderma composition has remarkable inhibitory action to EL_4 lymphoma, H22 tumor in the growth of body tumor, to the immune organs such as liver spleen of tumor-bearing mice without obvious inhibitory action.
Test example 3 clinical trials
From 1977-2011 years, cumulative observation 385 routine various cancers patients' clinical effectiveness, male 258 examples, female's 127 examples, between 2-81 years old ages.Wherein patient with advanced cancer 210, mid-terms 155 example, early stage 20 examples, enumerate part model case below:
Model case 1(malignant brain tumor)
Man, 10 years old, through Beijing, the Temple of Heaven tumour hospital was diagnosed as malignant brain tumor, through chemicotherapy, there is apparent side effect reflection in child, nausea and vomiting, lose hair, constipation, leucocytes reduction, focus strengthens, brain bears water.Take the bitter Ganoderma tumor suppression of the present invention capsule, after three days, occur toxin expelling phenomenon, the thing that the loose stool stench stasis of blood is black, obviously spirit takes a turn for the better, and putting side effect disappears.Through the bimestrial oral radiotherapy that adds local external application for curing and 30 times, at radiation period non-evident effect, reflect again.
Model case 2(cancer eye)
Man, 58 years old, Baoshan, Yunnan people, be diagnosed as pernicious cancer eye, tumor growth can not be performed the operation at arteries position, through treating without obvious curative effects more than a year, otherwise increase the weight of gradually tumor, increase in eyes hemorrhagely, severe headache, edema of lower limbs, difficulty in walking, diet sleep are listless.Use the bitter Ganoderma tumor suppression of the present invention capsule, after 3 days, pain relief, hemorrhage minimizing, appetite strengthen, and after 5 days, pain is not obvious, and tumor also has and diminishes, stopped bleeding, and appetite sleep spirit is still good, and edema of lower limbs disappears, can Ambulatory Activity.
Model case 3(cervical cancer)
Female, 57 years old, people from Jianyang City, cervical cancer postoperative recurrence, the soft broken group of heap volume 2cm*1.5cm*1cm of Vaginal Stump taupe.Take bitter Ganoderma tumor suppression capsule every day 3 times, 2 tablets/time, occur toxin expelling phenomenon, loose stool stench the 3rd day morning; Continue to take 3 days, symptom is clearly better, and spirit is improved appetite and increased, and abdominal distention disappearance pain relief continues to take 20 days check adnexa bladders, bilateral adnexa pelvic cavity and shows no obvious abnormalities.
Model case 4(nasopharyngeal carcinoma)
Lee, man, 40 years old, people from Jianyang, was diagnosed as pernicious nasopharyngeal carcinoma, through 1 week chemotherapy, without being clearly better, was clearly better after taking bitter Ganoderma tumor suppression capsule, checked nasal cavity foreign normal after May.
Model case 5(renal carcinoma)
Cai, man, 40 years old, people from Luzhou, was diagnosed as malignant renal neoplasm (right side is), month after operation recurrence, that symptom has is weak, lose weight, inappetence, hematuria, pain, tumor increase.Medication is not quite clear invalid, change and take bitter Ganoderma tumor suppression capsule tumor suppression and after 5 days, occur slight bowel symptoms, slight stomachache, diarrhoea, loose stool stench cystose, symptom obviously alleviates, and after 1 month, spirit is good, appetite is normal, body weight increase, hematuria, pain, tumor disappear.Check routine blood test, the beautiful thing of tumor, carcinoembryonic antigen are normal.
Model case 6(pinealoma)
Lee, man, 17 years old, a paroxysmal pain, the not visible thing of right eye socket of the eye enlargement, unable walking, spirit is very poor, anorexia, and medication is not quite clear invalid.Stop using other medicines, use bitter Ganoderma tumor suppression capsule instead, every day 3 times, 0.5g/ time, after 3 days, there is loose stool malodorant shape, the swollen shape of right eye disappears gradually, and headache number of times reduces, spirit takes a turn for the better to some extent, thinks diet, can descend to walk.The large disappearance of rear right swelling around the eyes in 7 days, headache number of times reduces, spirit is good, appetite increases.
Model case 7(esophageal carcinoma)
Yellow, female, 60 years old, people from Sichuan, through Jianyang City medical courses in general institute, make a definite diagnosis advanced esophageal cancer, the water inlet of can not taking food in postoperative continuous ten days, health is obviously become thin, loose two days later through taking bitter Ganoderma, symptom is clearly better, and progressively feed, continues to take bitter Ganoderma and falls apart after 6 months, health, by rehabilitation gradually, can descend and work.
Model case 8(malignant lymphoma)
Liu, man, 8 years old, people from Chengdu, river is diagnosed as greatly malignant lymphoma late period, drug administration is not quite clear without positive effect, takes bitter Ganoderma loose after 15 days, after ear and groin drench to have and significantly reduce to disappear, and other symptom all disappears, routine blood test result is normal.
Model case 9(Palace cancer)
Lee, female, 50 years old, Cheng Dou Wan people from field, sub-Palace cancerometastasis is made a definite diagnosis by Sichuan Tumor Hospiatal, is in hospital expectant treatment after January, and effect is very poor, takes the loose treatment of bitter Ganoderma after one week, and it is soft that affected part turns, pain relief.
The subcutaneous lymphoma of model case 10()
Safe certain, man, 37 years old, village people was calmed down in Jianyang, abdomen thigh lymph, arm all have enlargement in various degree, matter hard, through Jianyang City institute of traditional Chinese medicine, are diagnosed as subcutaneous lymphoma, take medicine not quite clear, 6 months without positive effect, otherwise pleiades increase.Take bitter Ganoderma loose after, discharge two days later loose stool stench, have intestinal to wriggle, take continuously seven, abdomen femoral lymph node, the obvious deliquescing of arm lymph lump, dwindle and reduce, take continuously 15 days, other transference cures, the mental status is good.
Model case 11(hepatocarcinoma)
Thank certain, man, 73 years old, small-sized village nine people from society in San He town, Jianyang City, because of right abdomen pain and have firmly fast, were off one's feed, and complexion is dark yellow, and general weakness is made a definite diagnosis through the People's Hospital, Jianyang City; Later period of hepatocarcinoma, takes chemotherapeutics ominous, and effect is very poor, aggravation, and the pain increased, with hepatic ascites.Take bitter Ganoderma loose, within 4 days, have in a large number afterwards toxin expelling phenomenon, loose stool stench, has enterokinesia, and abdominal part swelling disappears, pain relief, and lump deliquescing, dwindles, and has rosy cheeks, and appetite increases, and health makes moderate progress.
Model case 12(gastric cancer)
Ten thousand certain, man, 75 years old, 2 groups of people of republicanism were calmed down in Yunlong, Jianyang, gastric cancer late period, blocked the difficulty of handling up, pain, diet difficulty is entered not drink water, and takes this medicine soft diet product and drinking-water of can taking food that is clearly better for seven days, pain disappears, continuous 1 month all right state of an illness of taking medicine is controlled.
Model case 13(breast carcinoma)
Lee, female, 65 years old, Jianyang Golden Horse people, right breast has lump, and matter is hard, the about fist of companion's pain, and there is each position enlargement lymph, through the People's Hospital, Jianyang, malignant galactophore cancerometastasis (late period) is made a definite diagnosis in check. can not perform the operation, and blood pressure 120～180, blood glucose is higher, take chemotherapeutics ominous, without positive effect.Take that bitter Ganoderma is loose to be clearly better after 4 days, pain relief, enclosed mass deliquescing, each position lymph reduces, and continues to take after 10 days, and each position lymph disappears, enclosed mass also obviously dwindles, pain relief, continues to take bitter Ganoderma loose, and 6 months lumps are contracted to and refer to female size, without other symptoms. blood pressure is normal, body weight increases, and appetite is good, and the mental status is good.
Model case 14(cyclomastopathy)
What certain, female, 38 years old, Jianyang letter people from city, was diagnosed as cyclomastopathy, and two breasts have obvious lump, pain, month premenstrual more very pain. and swelling is the time one year, takes Western medicine without positive effect.Change and take bitter Ganoderma loose 4 days, be clearly better, pain relief, enclosed mass deliquescing, reduces, and continues to take 10 days, and pain disappears, and lump fades away, and continues to take 20 days symptoms and all disappears, recovery from illness.
Model case 15(esophagus squamous cell carcinoma)
Zhang, blocks the difficulty of handling up, and pain is had a surplus for 3 years, through the People's Hospital, Jianyang, be diagnosed as esophagus squamous cell carcinoma late period, medicine for treatment is not quite clear without positive effect, and symptom is blocked the water inlet 14 days of seriously can not taking food, and takes that bitter Ganoderma is loose take a favorable turn for 4 days, can intake and liquid food, continuous take 4 days and be clearly better, feed water inlet normal, once can enter one to two bowl of soft diet, continue and take 10 days other transference cures again, sb.'s illness took a turn for the worse afterwards dies.
Model case 16(cardiac cancer)
Yuan, man, 79 years old, Yunlong, Jianyang and normal person, be diagnosed as cardiac cancer, the difficulty of handling up, vomiting diet does not enter, and takes loose seven days medicines of bitter Ganoderma pain that is clearly better and disappears and can take food, and drug withdrawal is recurred for one month, takes medicine again and takes a turn for the better continuous in four days.
Model case 17(breath tumor)
Liu, man, 65 years old, 5 groups of people of Yunlong Yang Wu, suffer from breath tumor, go out air inlet not smooth, and enlargement drops tears, the course of disease has more than 3 years, takes medicine not quite clear without positive effect, takes bitter Ganoderma and falls apart 2 days without positive effect drug withdrawal, further consultation takes the loose tumor that takes an evident turn for the better after 7 days of bitter Ganoderma and diminishes, continue and take the improvement in loose 10 days of bitter Ganoderma, further consultation breath tumor is obviously dwindled again, gives vent to anger unobstructed.
Model case 18(brain polyphyly arachnoid cyst)
Zou, female, 34 years old, suffer from brain polyphyly arachnoid cyst, take medicine not quite clear, without positive effect, symptom is section pain between head, dizzy, the difficult sleep of distension, bitter taste, dry, the pink shape of expectoration, spirit is not good enough, takes the loose anti-cancer and inhibiting tumor medicine of bitter Ganoderma, successful.
Model case 19(pulmonary carcinoma)
Yellow, female, 41 years old, people from Chengdu, West China Hospital is diagnosed as pulmonary carcinoma deterioration transfer clavicle the enlargement of obvious lymph lump, takes Western medicine without positive effect, and taking bitter Ganoderma tumor suppression capsule has obvious toxin expelling phenomenon after three days, and symptom is improved, and appetite increases, spirit is slept well.After 15 days, tumor has obvious inhibition and alleviation.
Below in conjunction with specific embodiment, the present invention is further described.
The specific embodiment
Every 1g of the bitter LINGZHI JIAONANG I of embodiment 1
Prescription:
Ganoderma 30g Radix Astragali 50g Poria 50g Herba Linderniae Crustaceae 50g Radix Salviae Miltiorrhizae 50g
Herba Portulacae Grandiflorae 50g Oldenlandia diffusa Roxb 50g Agrimony 50g Radix Puerariae 50g
Method for making: get raw material described in each, after mixing, dry and porphyrize, crosses 100 mesh sieve 4 times, and sterilizing, incapsulates by every 1g, obtains.
Every 0.5g of the bitter LINGZHI JIAONANG II of embodiment 2
Prescription:
Ganoderma 200g Radix Astragali 300g Poria 300g Herba Linderniae Crustaceae 300g Radix Salviae Miltiorrhizae 300g
Herba Portulacae Grandiflorae 300g Oldenlandia diffusa Roxb 300g Agrimony 300g Radix Puerariae 700g
Method for making:
Get raw material described in each, be ground into coarse powder, with after 75% soak with ethanol, heating and refluxing extraction 5 hours, filters, and filtrate recycling ethanol is tasteless to alcohol, mix with medicinal residues, mixed liquor decocts with water 4 hours, filters, and filtrate is condensed into fluid extract, obtain bitter glossy ganoderma composition, add dextrin, starch to granulate, add lubricant, incapsulate and get final product.
Every 0.25g of the bitter LINGZHI JIAONANG III of embodiment 3
Prescription:
Ganoderma 400g Radix Astragali 700g Poria 700g Herba Linderniae Crustaceae 700g Radix Salviae Miltiorrhizae 700g
Herba Portulacae Grandiflorae 700g Oldenlandia diffusa Roxb 700g Agrimony 700g Radix Puerariae 300g
Method for making: get raw material described in each, be soaked in water 2 hours, then decoct 3 times with 8 times of water gagings, each 25 minutes, merge the concentrated concentrated solution that to obtain after filtering each decoction liquor; Concentrated solution is added to ethanol and carry out precipitate with ethanol, filter, filtrate recycling ethanol to without alcohol taste, is reclaimed to liquid again after fine straining, sterilizing, obtain bitter glossy ganoderma composition, add dextrin, starch to granulate, add lubricant, incapsulate and get final product.
The bitter Ganoderma of embodiment 4 is loose
Prescription:
Ganoderma 300g Radix Astragali 500g Poria 500g Herba Linderniae Crustaceae 500g Radix Salviae Miltiorrhizae 500g
Herba Portulacae Grandiflorae 500g Oldenlandia diffusa Roxb 500g Agrimony 500g Radix Puerariae 500g
Method for making: get raw material described in each, be soaked in water 1.5 hours, then decoct 5 times with 6 times of water gagings, each 30 minutes, merge the concentrated concentrated solution that to obtain after filtering each decoction liquor; Concentrated solution is added to ethanol and carry out precipitate with ethanol, filter, filtrate recycling ethanol to without alcohol taste, is reclaimed to liquid again after fine straining, sterilizing, obtain bitter glossy ganoderma composition, dry, pulverize, obtain.
The bitter Ganoderma Ludicum Injection of embodiment 5
Prescription:
Ganoderma 350g Radix Astragali 550g Poria 550g Herba Linderniae Crustaceae 550g Radix Salviae Miltiorrhizae 550g
Herba Portulacae Grandiflorae 550g Oldenlandia diffusa Roxb 550g Agrimony 550g Radix Puerariae 550g
Method for making:
Get raw material described in each, be ground into coarse powder, with after 85% soak with ethanol, heating and refluxing extraction 6 hours, filters, and filtrate recycling ethanol is tasteless to alcohol, mix with medicinal residues, mixed liquor decocts with water 6 hours, filters, by filtrate thin up, after ultracentrifugation, through ultrafiltration, filtering with microporous membrane, fill, sterilizing, obtains.
The above embodiment is only that the preferred embodiment of the present invention is described; not scope of the present invention is limited; design under the prerequisite of spirit not departing from the present invention; various distortion and improvement that those of ordinary skills make technical scheme of the present invention, all should fall in the definite protection domain of claims of the present invention.
Claims (8)
1. for a bitter glossy ganoderma composition for oncotherapy, it is characterized in that, described compositions is to be prepared from by following weight parts raw material:
Ganoderma 20-40 Radix Astragali 30-70 Poria 30-70 Herba Linderniae Crustaceae 30-70
Radix Salviae Miltiorrhizae 30-70 Herba Portulacae Grandiflorae 30-70 Oldenlandia diffusa Roxb 30-70
Agrimony 30-70 Radix Puerariae 30-70.
2. bitter glossy ganoderma composition as claimed in claim 2, is characterized in that, the weight portion of described raw material consists of:
Ganoderma 30 Radix Astragali 50 Poria 50 Herba Linderniae Crustaceae 50 Radix Salviae Miltiorrhizaes 50
Herba Portulacae Grandiflorae 50 Oldenlandia diffusa Roxb 50 Agrimony 50 Radix Puerariaes 50.
3. the preparation method of arbitrary bitter glossy ganoderma composition as claimed in claim 1 or 2, is characterized in that, gets raw material described in each, be ground into coarse powder, after soak with ethanol with 65%-85%, heating and refluxing extraction 2-6 hour, filters, filtrate recycling ethanol is tasteless to alcohol, mix with medicinal residues, mixed liquor decocts with water 2-6 hour, filters, filtrate is condensed into fluid extract, obtains bitter glossy ganoderma composition.
4. the preparation method of arbitrary bitter glossy ganoderma composition as claimed in claim 1 or 2, is characterized in that, gets raw material described in each, the 1-2 hour that is soaked in water, then decocts 3-5 time with 6-10 times of water gaging, at every turn 20-30 minute, after filtering each decoction liquor, merge, through concentrating to obtain concentrated solution; Concentrated solution is added to ethanol and carry out precipitate with ethanol, filter, filtrate recycling ethanol to without alcohol taste, is reclaimed to liquid again after fine straining, sterilizing, obtain bitter glossy ganoderma composition.
5. arbitrary bitter glossy ganoderma composition as claimed in claim 1 or 2, is characterized in that, contains iridoid glycoside 0.1%-3% in described compositions.
6. the dosage form made from the arbitrary bitter glossy ganoderma composition in described in claim 1 or 2 and appropriate pharmacy adjuvant, is characterized in that, described dosage form is capsule, powder, tablet or injection.
7. dosage form as claimed in claim 6, is characterized in that, described dosage form is capsule, the method for making of described capsule is: get raw material described in each, after mixing, dry and porphyrize, crosses 80-120 mesh sieve 3-4 time, sterilizing, is respectively charged into capsule by 0.25g, 5g, 1g various dose.
8. the purposes of arbitrary bitter glossy ganoderma composition as claimed in claim 1 or 2, is characterized in that, the application of described bitter glossy ganoderma composition in the medicine for the preparation of sterilization or antiinflammatory.
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| CN103230454A (en) * | 2013-04-02 | 2013-08-07 | 常熟市厚福堂健康服务有限公司 | Cancer resisting and tumor restraining capsule and its preparation method |
| CN103230469A (en) * | 2013-04-02 | 2013-08-07 | 常熟市厚福堂健康服务有限公司 | Hemorrhoid rehabilitation traditional Chinese medicine |
| CN103230449A (en) * | 2013-04-02 | 2013-08-07 | 常熟市厚福堂健康服务有限公司 | Rupikang traditional Chinese medicine |
| CN104922382A (en) * | 2015-06-15 | 2015-09-23 | 张英杰 | Chinese patent medicine oral pills for treating lymphoma |
| CN109381575A (en) * | 2018-11-19 | 2019-02-26 | 厦门妙九科技开发有限公司 | A kind of Chinese medicine that can significantly reduce PD-L1 expression |
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Effective date of registration: 20151023 Address after: Under a Red Village Park 215500 ancient town in Jiangsu province Changshou City miaoquan Patentee after: Zhu Wei Address before: 610059, No. 1, unit 40, three section, two ring road, Chengdu, Sichuan, Chenghua District, 2 Patentee before: Xie Yu |