CN104800724B - Improve the medicine of toxicity after chemotherapy of tumors - Google Patents

Abstract

The invention provides a kind of medicine for improving toxicity after chemotherapy of tumors, its crude drug comprises the Radix Astragali, Radix Ginseng, Semen Euryales, Pollen Typhae, Fructus Psoraleae, Poria, Radix Liriopes, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati, Radix Morindae Officinalis, Semen Alpiniae Katsumadai, Radix Coicis, Herba Asteris Ageratoidis, Ramulus et Folium Debregeasiae Edulis, Herba Lamii Amplexicaulis, rabbit hair Artemisia, Herba Hydrocotyles, Herba Euphorbiae Humifusae and Cortex Phellodendri.This medicine combined with chemotherapy treatment tumor, improves the life quality of tumor patient, effectively alleviates the untoward reaction of chemotherapy, have no adverse reaction after medication, and medicine source is abundant economical and practical again, is worthy to be popularized.

Description

Improve the medicine of toxicity after chemotherapy of tumors

Technical field

The present invention relates to technical field of Chinese medicine, particularly relate to a kind of medicine improving toxicity after chemotherapy of tumors.

Background technology

Malignant tumor is the commonly encountered diseases of serious threat human health, frequently-occurring disease, is one of disease causing human spirit's pressure maximum.Due to during when most of patients is gone to a doctor, the state of an illness belongs to, late period, usually need to carry out chemotherapy.But the toxicity of chemicals seriously can affect spirit, the muscle power of patient, there is digestive tract reaction, inappetence etc., correct not in time and can make patients with low immunity, leukocyte reduces, cause serious infection, even threat to life, patient for treatment also can be made to lose the confidence, have impact on the life quality of patient thus, reduce life cycle.How to improve the sensitivity of tumours of chemotherapeutic agents and the untoward reaction alleviating chemotherapeutics more and more attracts people's attention in current therapeutic field of tumor and is worth the problem inquired into.

Chemotherapy of tumors is equivalent to " treating the poisonous disease with poisonous drugs " of Chinese medicine, namely while performance its " anticancer get rid of evils " acts on, and " healthy energy " of damage human body, thus produce various toxicity.Chinese medicine extremely focuses on the healthy energy of human body, think tumor generation and transfer and human-body viscera function weakens, negative and positive of qi and blood is lacked of proper care, healthy energy virtual loss, that pathogen gos deep into environment is closely related.Chinese medicine thinks that chemical therapy toxic side effect is that in malicious evil intrusive body, wasting QI-blood, body fluid, injure caused by internal organs.Chemicals impairing the spleen and stomach, causes dysfunction of the spleen in transportation, stops in evil poison, burnt in retardance, stomach-QI being unable to descend normally, adverse rising of stomach-QI and cause nausea, vomit.Patients undergoing chemotherapy is mostly the people of prolonged illness weakness, and medicine is sent an expedition against too in addition, and causes weakness of the spleen and stomach, can not be disappeared digesting and absorbing the essence of foodstuff, transmitting and distributing the fluids, causes food stagnation in interior, retention of water-damp in the body, thus there is the diseases such as spiritlessness and weakness, inappetence, nausea and vomiting, abdominal distention diarrhoea, treatment should invigorating the spleen and regulating the stomach, stopping nausea and vomiting by lowering the adverse flow of QI.In the application of Chinese medicine combined with chemotherapy, note from start to finish protecting gastric qi, because of " people is this with gastric qi ", " patient with full stomach-QI being easy to treat and having a favorable prognosis, extreme hypofunction of the stomach is then dead ".The toxic and side effects of chemotherapy can be avoided or alleviate to Chinese medicine to a certain extent, and protection internal organs, from damage, can also strengthen the sensitivity of cancerous cell to chemotherapeutics, improve immunity, and then improve the quality of life of patient.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of medicine for improving toxicity after chemotherapy of tumors, its combined with chemotherapy treatment tumor, improve the life quality of tumor patient, effectively alleviate the untoward reaction of chemotherapy, have no adverse reaction after medication, and medicine source is abundant economical and practical again, is worthy to be popularized.

For solving the problems of the technologies described above, the invention provides a kind of medicine for improving toxicity after chemotherapy of tumors, its crude drug comprises the Radix Astragali, Radix Ginseng, Semen Euryales, Pollen Typhae, Fructus Psoraleae, Poria, Radix Liriopes, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati, Radix Morindae Officinalis, Semen Alpiniae Katsumadai, Radix Coicis, Herba Asteris Ageratoidis, Ramulus et Folium Debregeasiae Edulis, Herba Lamii Amplexicaulis, rabbit hair Artemisia, Herba Hydrocotyles, Herba Euphorbiae Humifusae and Cortex Phellodendri.

Wherein, in described medicine, the weight of each crude drug is respectively Radix Astragali 55g ~ 65g, Radix Ginseng 35g ~ 45g, Semen Euryales 20g ~ 30g, Pollen Typhae 25g ~ 35g, Fructus Psoraleae 20g ~ 30g, Poria 25g ~ 35g, Radix Liriopes 20g ~ 30g, Rhizoma Polygonati 25g ~ 35g, Radix Salviae Miltiorrhizae 35g ~ 45g, Caulis Spatholobi 25g ~ 35g, Herba Hedyotidis Diffusae 20g ~ 30g, Rhizoma Polygoni Cuspidati 25g ~ 35g, Radix Morindae Officinalis 20g ~ 30g, Semen Alpiniae Katsumadai 25g ~ 35g, Radix Coicis 20g ~ 30g, Herba Asteris Ageratoidis 25g ~ 35g, Ramulus et Folium Debregeasiae Edulis 15g ~ 25g, Herba Lamii Amplexicaulis 20g ~ 30g, rabbit hair Artemisia 25g ~ 35g, Herba Hydrocotyles 15g ~ 25g, Herba Euphorbiae Humifusae 20g ~ 30g and Cortex Phellodendri 25g ~ 35g.

Wherein, in described medicine, the weight of each crude drug is respectively Radix Astragali 58g ~ 62g, Radix Ginseng 38g ~ 42g, Semen Euryales 23g ~ 27g, Pollen Typhae 28g ~ 32g, Fructus Psoraleae 23g ~ 27g, Poria 28g ~ 32g, Radix Liriopes 23g ~ 27g, Rhizoma Polygonati 28g ~ 32g, Radix Salviae Miltiorrhizae 38g ~ 42g, Caulis Spatholobi 28g ~ 32g, Herba Hedyotidis Diffusae 23g ~ 27g, Rhizoma Polygoni Cuspidati 28g ~ 32g, Radix Morindae Officinalis 23g ~ 27g, Semen Alpiniae Katsumadai 28g ~ 32g, Radix Coicis 23g ~ 27g, Herba Asteris Ageratoidis 28g ~ 32g, Ramulus et Folium Debregeasiae Edulis 18g ~ 22g, Herba Lamii Amplexicaulis 23g ~ 27g, rabbit hair Artemisia 28g ~ 32g, Herba Hydrocotyles 18g ~ 22g, Herba Euphorbiae Humifusae 23g ~ 27g and Cortex Phellodendri 28g ~ 32g.

Wherein, in described medicine, the weight of each crude drug is respectively Radix Astragali 60g, Radix Ginseng 40g, Semen Euryales 25g, Pollen Typhae 30g, Fructus Psoraleae 25g, Poria 30g, Radix Liriopes 25g, Rhizoma Polygonati 30g, Radix Salviae Miltiorrhizae 40g, Caulis Spatholobi 30g, Herba Hedyotidis Diffusae 25g, Rhizoma Polygoni Cuspidati 30g, Radix Morindae Officinalis 25g, Semen Alpiniae Katsumadai 30g, Radix Coicis 25g, Herba Asteris Ageratoidis 30g, Ramulus et Folium Debregeasiae Edulis 20g, Herba Lamii Amplexicaulis 25g, rabbit hair Artemisia 30g, Herba Hydrocotyles 20g, Herba Euphorbiae Humifusae 25g and Cortex Phellodendri 30g.

Wherein, described medicine can be sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, granule, electuary, pill, powder, sublimed preparation, solution or injection.

Wherein, described medicine can be oral liquid and powder.

Wherein, can add medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: one or more in starch, sucrose, Mel, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, Tween 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Pulvis Talci, magnesium stearate, calcium stearate.

Present invention also offers the preparation method of said medicine, be specially:

The first step, takes Fructus Psoraleae by weight and pulverizes, cross 40 mesh sieves, carry out CO ₂supercritical extraction, extracting pressure 27MPa, extraction temperature 70 DEG C, CO ₂flow is 4.5 ~ 5L/h, and extraction time is 3h, obtains extractum shape extract, and with the silica gel adsorption of granularity 200 ~ 300 order, petroleum ether carries out eluting, collects eluent, reclaims petroleum ether, obtains Fructus Psoraleae extract;

Second step, take the Radix Astragali, Radix Ginseng, Semen Euryales, Radix Liriopes, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Morindae Officinalis, Semen Alpiniae Katsumadai, Ramulus et Folium Debregeasiae Edulis, Herba Lamii Amplexicaulis, Herba Euphorbiae Humifusae and Cortex Phellodendri by weight, pulverize respectively, cross 40 mesh sieves, mixing, with the alcohol reflux 3 times of the determining alcohol 60% ~ 80% of the mixture quality obtained relative to this step 5 ~ 7 times, each 2 hours, merge extractive liquid, filters; Filtrate is adjusted to pH5.5 ~ 7 by NaOH solution, leaves standstill, filter, decompression filtrate recycling ethanol, to without alcohol taste, leaves standstill, centrifugalize, the supernatant after centrifugalize, and the heating relative density be concentrated at 50 DEG C ~ 60 DEG C is the mastic of 1.15 ~ 1.20;

3rd step, take remaining components by weight, pulverize respectively, cross 40 mesh sieves, mix acquisition mixture by above-mentioned weight, add the soak by water twice relative to mixture quality 3 ~ 5 times, each decoction 1 hour ~ 2 hours, filter respectively, merging filtrate, during dense 50 DEG C ~ 60 DEG C of filtrate, relative density is the mastic of 1.25 ~ 1.30;

4th step, the mastic mixing first three step obtained, is prepared into various dosage form as required.

Wherein, when prepared dosage form is powder, puts into oven drying after being specially the mastic mixing first three step obtained and obtain mixed powder, get 500g medicated powder, add 500g starch, be uniformly mixed, obtain powder.

Wherein, when prepared dosage form is oral liquid, be specially the mastic mixture 150g first three step obtained, it is appropriate to add Mel 100g, sucrose 90g, sodium benzoate 3.0g and water, mixing, hydro-oxidation sodium test solution adjust pH to 5 ~ 6, add water to 1000ml, filter, embedding, sterilizing, to obtain final product.

Beneficial effect of the present invention:

Medicine for improving toxicity after chemotherapy of tumors provided by the invention, its combined with chemotherapy treatment tumor, improves the life quality of tumor patient, effectively alleviate the untoward reaction of chemotherapy, have no adverse reaction after medication, and medicine source is abundant economical and practical again, is worthy to be popularized.

Detailed description of the invention

The invention provides a kind of medicine for improving toxicity after chemotherapy of tumors, its crude drug comprises the Radix Astragali, Radix Ginseng, Semen Euryales, Pollen Typhae, Fructus Psoraleae, Poria, Radix Liriopes, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati, Radix Morindae Officinalis, Semen Alpiniae Katsumadai, Radix Coicis, Herba Asteris Ageratoidis, Ramulus et Folium Debregeasiae Edulis, Herba Lamii Amplexicaulis, rabbit hair Artemisia, Herba Hydrocotyles, Herba Euphorbiae Humifusae and Cortex Phellodendri.

Further preferably, described medicine is only made up of above-mentioned raw materials medicine.

Fang Zhong, Pollen Typhae, Fructus Psoraleae can promote granulocyte and megalokaryocyte ripen in advance, improve leukocyte and platelet counts, Semen Alpiniae Katsumadai, Herba Asteris Ageratoidis can alleviate reduce chemotherapeutics cause feel sick, inappetence, the digestive tract reactions such as abdominal distention, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati, Poria, Herba Euphorbiae Humifusae can alleviate or eliminate the hemorrhagic cystitis and urinary tract infection symptom that chemotherapy causes, Radix Morindae Officinalis, Rhizoma Polygonati, it is weak that Herba Hydrocotyles can improve rapidly that chemotherapy causes, the weak symptom waiting whole body not relax, the Radix Astragali, Radix Ginseng, Semen Euryales, Radix Liriopes can improve the immunologic function of tumor patient, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Ramulus et Folium Debregeasiae Edulis, Herba Lamii Amplexicaulis, rabbit hair Artemisia energy blood vessel dilating, accelerate blood flow, promote diffusion and the transfer of cancerous cell, Radix Coicis, Cortex Phellodendri can expand the blood vessel around cancer block, and make chemotherapeutics easily penetrate into cancer block depths, and activated T cell and NK cell, chemotherapeutics is made easily to suppress and kill and wound cancerous cell, all medicines share giving consideration to both the incidental and fundamental, strengthening vital QI to eliminate pathogenic factors is with enhancing human body immunity ability.

In described medicine, the weight of each crude drug is respectively Radix Astragali 55g ~ 65g, Radix Ginseng 35g ~ 45g, Semen Euryales 20g ~ 30g, Pollen Typhae 25g ~ 35g, Fructus Psoraleae 20g ~ 30g, Poria 25g ~ 35g, Radix Liriopes 20g ~ 30g, Rhizoma Polygonati 25g ~ 35g, Radix Salviae Miltiorrhizae 35g ~ 45g, Caulis Spatholobi 25g ~ 35g, Herba Hedyotidis Diffusae 20g ~ 30g, Rhizoma Polygoni Cuspidati 25g ~ 35g, Radix Morindae Officinalis 20g ~ 30g, Semen Alpiniae Katsumadai 25g ~ 35g, Radix Coicis 20g ~ 30g, Herba Asteris Ageratoidis 25g ~ 35g, Ramulus et Folium Debregeasiae Edulis 15g ~ 25g, Herba Lamii Amplexicaulis 20g ~ 30g, rabbit hair Artemisia 25g ~ 35g, Herba Hydrocotyles 15g ~ 25g, Herba Euphorbiae Humifusae 20g ~ 30g and Cortex Phellodendri 25g ~ 35g.

Further preferably, in described medicine, the weight of each crude drug is respectively Radix Astragali 58g ~ 62g, Radix Ginseng 38g ~ 42g, Semen Euryales 23g ~ 27g, Pollen Typhae 28g ~ 32g, Fructus Psoraleae 23g ~ 27g, Poria 28g ~ 32g, Radix Liriopes 23g ~ 27g, Rhizoma Polygonati 28g ~ 32g, Radix Salviae Miltiorrhizae 38g ~ 42g, Caulis Spatholobi 28g ~ 32g, Herba Hedyotidis Diffusae 23g ~ 27g, Rhizoma Polygoni Cuspidati 28g ~ 32g, Radix Morindae Officinalis 23g ~ 27g, Semen Alpiniae Katsumadai 28g ~ 32g, Radix Coicis 23g ~ 27g, Herba Asteris Ageratoidis 28g ~ 32g, Ramulus et Folium Debregeasiae Edulis 18g ~ 22g, Herba Lamii Amplexicaulis 23g ~ 27g, rabbit hair Artemisia 28g ~ 32g, Herba Hydrocotyles 18g ~ 22g, Herba Euphorbiae Humifusae 23g ~ 27g and Cortex Phellodendri 28g ~ 32g.

Most preferably, in described medicine, the weight of each crude drug is respectively Radix Astragali 60g, Radix Ginseng 40g, Semen Euryales 25g, Pollen Typhae 30g, Fructus Psoraleae 25g, Poria 30g, Radix Liriopes 25g, Rhizoma Polygonati 30g, Radix Salviae Miltiorrhizae 40g, Caulis Spatholobi 30g, Herba Hedyotidis Diffusae 25g, Rhizoma Polygoni Cuspidati 30g, Radix Morindae Officinalis 25g, Semen Alpiniae Katsumadai 30g, Radix Coicis 25g, Herba Asteris Ageratoidis 30g, Ramulus et Folium Debregeasiae Edulis 20g, Herba Lamii Amplexicaulis 25g, rabbit hair Artemisia 30g, Herba Hydrocotyles 20g, Herba Euphorbiae Humifusae 25g and Cortex Phellodendri 30g.

Each crude drug pharmacology is as follows:

The Radix Astragali: latin name astragaliradix, sweet in the mouth, warm in nature, enter spleen, lung meridian, there is benefit strengthening spleen and lung, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, the effects such as holder skin ulcer granulation promoting, are mainly used in the weak anorexia and loose stool that deficiency of both the splenic and pulmonary QI is caused, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, the cards such as insufficiency of vital energy and blood.

Radix Ginseng: sweet in the mouth, micro-hardship, slightly warm in nature, enter the heart, lung, spleen channel, have strongly invigorating primordial QI, using tonifying Qi reinforcing lungs, promoting the production of body fluid to quench thirst, to calm the nerves the effects such as Fructus Alpiniae Oxyphyllae, both for emergency treatment of collapse holds up good dose of danger, also for treating the first key medicine of asthenia internal injury, the card of all insufficiency of vital energy and bloods all can be applied, cure mainly that impairment caused by overstrain is deficient, food told in lack of appetite, asthenia, regurgitation, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, the card such as woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency are multiple.

Semen Euryales: sweet in the mouth, puckery, property is put down.Return spleen, kidney channel.Have supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping, cures mainly emission, diarrhea due to hypofunction of the spleen, and insufficiency of the spleen nebulousurine is with inferior card.

Pollen Typhae: sweet in the mouth, property is put down, and enters liver, pericardium channel, has hemostasis, blood stasis dispelling, treating stranguria effect.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, the cards such as blood strangury and dry pain.

Fructus Psoraleae: acrid in the mouth, hardship, warm in nature, enter kidney, spleen channel, have kidney invigorating and YANG supporting, warming spleen and stopping diarrha effect, is mainly used in decline of the fire from the gate of life, the chills and pain of the waist and kness of below element deficiency and cold, frequent urination and enuresis, sexual impotence lingering diarrhea; Insufficiency of kidney-YANG, spleen soil loses using warming therapy stomachache limb and trembles with fear, the cards such as Diarrhoea.

Poria: sweet in the mouth, light, property is put down, and enters the heart, lung, spleen, kidney channel, has the effect of eliminating dampness and diuresis, spleen invigorating mind calming, be mainly used in the edema of retention of water-damp, dysuria; The pyretic stranguria of damp-heat accumulation, the card such as anorexia and loose stool, phlegm retention stagnation, epilepsy of stagnation of dampness due to deficiency of the spleen.

Radix Liriopes: latin name liriopesradix, sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, and for dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, vexed insomnia, the cards such as dryness of the intestine constipation.

Rhizoma Polygonati: sweet in the mouth, property is put down, and returns lung, spleen, kidney channel, has nourishing kidney lung moistening, effect of invigorating the spleen and replenishing QI, cures mainly deficiency of YIN chronic cough, xeropulmonary cough, insufficiency of the spleen weak, and lack of appetite xerostomia, quenches one's thirst, deficiency of the kidney soreness of the waist and knees, impotence and seminal emission, tinnitus order is dark, early whitening of beard and hair, and body void is won thin, effect of wind favus disease.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold in nature, enters the heart, Liver Channel, has the effect of blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis, removing heat from blood mind calming, be mainly used in the ambition of stagnation of QI and blood, the twinge of the breast side of body, sensation of oppression over the chest with shortness of breath, abdominal distention; The menoxenia of women's disharmony between QI and blood, dysmenorrhoea amenorrhea; Stagnation of QI-blood, the cards such as trusted subordinate's pain.

Caulis Spatholobi: latin name spatholobicaulis, bitter in the mouth, sweet, warm in nature, enter liver, kidney channel, there is blood vessel dilating, enrich blood and invigorate blood circulation, regulating menstruation, the effect of relaxing muscles and tendons and activating QI and blood in the collateral, there is obvious inhibitory action to platelet aggregation, promote animal kidney and the total phosphorus metabolism in uterus, be mainly used in treating the menoxenia that blood deficiency has silt, limbs pain is meciless, the card such as soreness of the waist and knees, pain.

Herba Hedyotidis Diffusae: bitter in the mouth, sweet, cold in nature, enters the heart, liver, spleen, large intestine channel, has heat-clearing and toxic substances removing, the effect of promoting diuresis to eliminate damp pathogen, for dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, the cards such as cancerous protuberance.

Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature, returns liver, gallbladder, lung meridian, has heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, effect of relieving cough and resolving phlegm, for arthralgia, jaundice due to damp-heat, amenorrhea WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, the cards such as carbuncle sore tumefacting virus.

Radix Morindae Officinalis: latin name MorindaeOfficinalisRadix, acrid in the mouth, sweet, slightly warm in nature, enter liver, kidney channel, there is effect of kidney-replenishing, bone and muscle strengthening, wind-damp dispelling, for impotence due to deficiency of the kidney, seminal emission premature ejaculation, few abdomen cold type of pain, cold womb is infertile, the cards such as the muscles and bones flaccidity caused by deficiency of the liver and kindey is soft, chills and pain of the waist and kness.

Semen Alpiniae Katsumadai: acrid in the mouth, warm in nature, return spleen, stomach warp, there is effect of dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, cure mainly internal retention of cold wetness, distension and fullness in the abdomen cold type of pain, belch vomiting, the cards such as anorexia.

Radix Coicis: be the root welding technology of grass family Coix plant Semen Coicis, sweet in the mouth, light, cold nature, returns spleen, urinary bladder channel, has clearing away heat and cooling blood, relieving stranguria by diuresis, effect of passive parasite killing, cures mainly pyretic stranguria, stranguria with blood, stranguria marked by chyluria, bleeding not during menses, edema, jaundice due to damp-heat, the cards such as ascariasis.

Herba Asteris Ageratoidis: be herb or the root of Compositae Aster plant three arteries and veins Radix Asteris, bitter in the mouth, pungent, cool in nature, there is heat-clearing and toxic substances removing, the effect of the removing heat from blood that eliminates the phlegm, cure mainly cold, fever, tonsillitis, bronchitis, hepatitis, enteritis, dysentery, pyretic stranguria, heat in blood, the cards such as worm venom.

Ramulus et Folium Debregeasiae Edulis: be the branch and leaf of Urticaceae Debregeasia orientalis C. J. Chen platymiscium Debregeasia orientalis C. J. Chen, acrid in the mouth, micro-hardship, cool in nature, have dispelling wind cough-relieving, clearing heat for promoting eruption, effect of removing stasis to stop bleeding, cures mainly exogenous cough, hemoptysis, acute infantile convulsion wind, measles without adequate eruption, traumatic injury, the card such as enclosed mass in women's abdomen.

Herba Lamii Amplexicaulis: be the herb of Labiatae lamium plant Herba Lamii Amplexicaulis, acrid in the mouth, hardship, slightly warm in nature, has promoting blood circulation to remove obstruction in the collateral, and effect of removing toxic substances and promoting subsidence of swelling, cures mainly traumatic injury, bones and muscles pain, numb limbs and tense tendons, hemiplegia, facial paralysis, jaundice, nasal sinusitis, toxic swelling, the cards such as impetigo.

Rabbit hair Artemisia: be the herb of Compositae line Dendranthema Filifolium sibiricum (Linn.) Kitam., bitter in the mouth, cold in nature, there is heat-clearing and toxic substances removing, anti-inflammation, calm the nerves relieving convulsion, effect of regulating menstruation, hemostasis, cure mainly the high heat of infectious disease, heart beating, insomnia, neurasthenia, menorrhagia, the cards such as menoxenia.

Herba Hydrocotyles: acrid in the mouth, micro-hardship, cool in nature, have clearing away heat-damp and promoting diuresis, effect of removing toxic substances and promoting subsidence of swelling, cures mainly jaundice, dysentery, edema, stranguria, and larynx swells, herpes zoster, the cards such as traumatic injury.

Herba Euphorbiae Humifusae: acrid in the mouth, property is put down, return liver, large intestine channel, there is the effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, damp-heat dysentery, urine leaching pain, jaundice, various go out the treatment of blood disorder etc., Herba Euphorbiae Humifusae has effect that is antibacterial or sterilization to staphylococcus aureus, Hemolytic streptococcus, diphtheria corynebacterium, escherichia coli, dysentery bacterium etc.

Cortex Phellodendri: latin name PhellodendriAmurensisCortex, cold in nature, bitter in the mouth, return kidney, urinary bladder channel, have heat clearing and damp drying, pathogenic fire purging is except steaming, effect of detoxification sore treatment, cures mainly the cards such as damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin.

Present invention also offers the preparation method of said medicine, be specially:

The first step, takes Fructus Psoraleae by weight and pulverizes, cross 40 mesh sieves, carry out CO ₂supercritical extraction, extracting pressure 27MPa, extraction temperature 70 DEG C, CO ₂flow is 4.5 ~ 5L/h, and extraction time is 3h, obtains extractum shape extract, and with the silica gel adsorption of granularity 200 ~ 300 order, petroleum ether carries out eluting, collects eluent, reclaims petroleum ether, obtains Fructus Psoraleae extract;

Second step, take the Radix Astragali, Radix Ginseng, Semen Euryales, Radix Liriopes, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Morindae Officinalis, Semen Alpiniae Katsumadai, Ramulus et Folium Debregeasiae Edulis, Herba Lamii Amplexicaulis, Herba Euphorbiae Humifusae and Cortex Phellodendri by weight, pulverize respectively, cross 40 mesh sieves, mixing, with the alcohol reflux 3 times of the determining alcohol 60% ~ 80% of the mixture quality obtained relative to this step 5 ~ 7 times, each 2 hours, merge extractive liquid, filters; Filtrate is adjusted to pH5.5 ~ 7 by NaOH solution, leaves standstill, filter, decompression filtrate recycling ethanol, to without alcohol taste, leaves standstill, centrifugalize, the supernatant after centrifugalize, and the heating relative density be concentrated at 50 DEG C ~ 60 DEG C is the mastic of 1.15 ~ 1.20;

3rd step, take remaining components by weight, pulverize respectively, cross 40 mesh sieves, mix acquisition mixture by above-mentioned weight, add the soak by water twice relative to mixture quality 3 ~ 5 times, each decoction 1 hour ~ 2 hours, filter respectively, merging filtrate, during dense 50 DEG C ~ 60 DEG C of filtrate, relative density is the mastic of 1.25 ~ 1.30;

4th step, the mastic mixing first three step obtained, is prepared into various dosage form as required.

Medicine provided by the invention is endo-medicine, various regular dosage form can be prepared into according to customary preparation methods, can be preferably sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, granule, electuary, pill, powder, sublimed preparation, solution or injection, more preferably oral liquid and powder.

Can add medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: one or more in starch, sucrose, Mel, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, Tween 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Pulvis Talci, magnesium stearate, calcium stearate.

When prepared dosage form is powder, puts into oven drying after being specially the mastic mixing first three step obtained and obtain mixed powder, get 500g medicated powder, add 500g starch, be uniformly mixed, obtain powder.

When prepared dosage form is oral liquid, be specially the mastic mixture 150g first three step obtained, add Mel 100g, sucrose 90g, sodium benzoate 3.0g and water in right amount, mixing, hydro-oxidation sodium test solution adjust pH to 5 ~ 6, add water to 1000ml, filter, embedding, sterilizing, to obtain final product.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 powder 1

Take Fructus Psoraleae 25g to pulverize, cross 40 mesh sieves, carry out CO ₂supercritical extraction, extracting pressure 27MPa, extraction temperature 70 DEG C, CO ₂flow is 5L/h, extraction time is 3h, obtain extractum shape extract, with the silica gel adsorption of granularity 200 order, petroleum ether carries out eluting, collect eluent, reclaim petroleum ether, obtain Fructus Psoraleae extract, take Radix Astragali 60g, Radix Ginseng 40g, Semen Euryales 25g, Radix Liriopes 25g, Rhizoma Polygonati 30g, Radix Salviae Miltiorrhizae 40g, Caulis Spatholobi 30g, Radix Morindae Officinalis 25g, Semen Alpiniae Katsumadai 30g, Ramulus et Folium Debregeasiae Edulis 20g, Herba Lamii Amplexicaulis 25g, Herba Euphorbiae Humifusae 25g and Cortex Phellodendri 30g, pulverize respectively, cross 40 mesh sieves, mixing, with the alcohol reflux 3 times of the determining alcohol 80% of 2.5kg, each 2 hours, merge extractive liquid, filtered, filtrate is adjusted to pH6 by NaOH solution, leave standstill, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, leave standstill, centrifugalize, supernatant after centrifugalize, the heating relative density be concentrated at 60 DEG C is the mastic of 1.20, take Pollen Typhae 30g, Poria 30g, Herba Hedyotidis Diffusae 25g, Rhizoma Polygoni Cuspidati 30g, Radix Coicis 25g, Herba Asteris Ageratoidis 30g, rabbit hair Artemisia 30g, Herba Hydrocotyles 20g, pulverize respectively, cross 40 mesh sieves, mix acquisition mixture, add the soak by water twice of 900g, each decoction 2 hours, filter respectively, merging filtrate, during dense 60 DEG C of filtrate, relative density is the mastic of 1.30, by the mastic mixing obtained, put into oven drying after mixing and obtain mixed powder, get 500g medicated powder, add 500g starch, be uniformly mixed, obtain powder 1.

Toxicology test

(herbal pharmacology research methodology, Qi Chen edits reference literature method.People's Health Publisher, 1993 the 1st edition, 112) Kun Ming mice 40 is got, male and female half and half, body weight 20 ± 2g, be divided into Normal group and administration group by mice every 10g body weight gavage 0.4mL medicine (reaching maximum volume), be administered twice in one day (Normal group is to equal-volume normal saline), the medicine of institute's gavage is powder 1 prepared by embodiment 1, and being condensed into crude drug concentration is 1g/mL.Observe immediately after administration to 6 hours, later every day observes, continuous 14 days; 8th day anatomic observation, Continuous Observation 7 days.Animal is smooth by hair, active, natural hole is limpid, defecation is normal, through t inspection between matched group and administration group, and no significant difference.The each main organs of anatomic observation white mice is all without naked eyes lesions visible.Mice is maximum reaches 80g/kg to amount, and by body-mass index conversion, adult's (60 kilograms) consumption per day reaches 4800g, and be 160 times of clinical analog quantity, it, higher than clinical application consumption 100 times, is safe.

Embodiment 2 powder 2

Take Fructus Psoraleae 23g to pulverize, cross 40 mesh sieves, carry out CO ₂supercritical extraction, extracting pressure 27MPa, extraction temperature 70 DEG C, CO ₂flow is 5L/h, extraction time is 3h, obtain extractum shape extract, with the silica gel adsorption of granularity 200 order, petroleum ether carries out eluting, collect eluent, reclaim petroleum ether, obtain Fructus Psoraleae extract, take Radix Astragali 58g, Radix Ginseng 38g, Semen Euryales 23g, Radix Liriopes 23g, Rhizoma Polygonati 28g, Radix Salviae Miltiorrhizae 38g, Caulis Spatholobi 28g, Radix Morindae Officinalis 23g, Semen Alpiniae Katsumadai 28g, Ramulus et Folium Debregeasiae Edulis 18g, Herba Lamii Amplexicaulis 23g, Herba Euphorbiae Humifusae 23g and Cortex Phellodendri 28g, pulverize respectively, cross 40 mesh sieves, mixing, with the alcohol reflux 3 times of the determining alcohol 80% of 2.5kg, each 2 hours, merge extractive liquid, filtered, filtrate is adjusted to pH6 by NaOH solution, leave standstill, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, leave standstill, centrifugalize, supernatant after centrifugalize, the heating relative density be concentrated at 60 DEG C is the mastic of 1.20, take Pollen Typhae 28g, Poria 28g, Herba Hedyotidis Diffusae 23g, Rhizoma Polygoni Cuspidati 28g, Radix Coicis 23g, Herba Asteris Ageratoidis 28g, rabbit hair Artemisia 28g, Herba Hydrocotyles 18g, pulverize respectively, cross 40 mesh sieves, mix acquisition mixture, add the soak by water twice of 900g, each decoction 2 hours, filter respectively, merging filtrate, during dense 60 DEG C of filtrate, relative density is the mastic of 1.30, by the mastic mixing obtained, put into oven drying after mixing and obtain mixed powder, get 500g medicated powder, add 500g starch, be uniformly mixed, obtain powder 2.

Embodiment 3 powder 3

Take Fructus Psoraleae 27g to pulverize, cross 40 mesh sieves, carry out CO ₂supercritical extraction, extracting pressure 27MPa, extraction temperature 70 DEG C, CO ₂flow is 5L/h, extraction time is 3h, obtain extractum shape extract, with the silica gel adsorption of granularity 200 order, petroleum ether carries out eluting, collect eluent, reclaim petroleum ether, obtain Fructus Psoraleae extract, take Radix Astragali 62g, Radix Ginseng 42g, Semen Euryales 27g, Radix Liriopes 27g, Rhizoma Polygonati 32g, Radix Salviae Miltiorrhizae 42g, Caulis Spatholobi 32g, Radix Morindae Officinalis 27g, Semen Alpiniae Katsumadai 32g, Ramulus et Folium Debregeasiae Edulis 22g, Herba Lamii Amplexicaulis 27g, Herba Euphorbiae Humifusae 27g and Cortex Phellodendri 32g, pulverize respectively, cross 40 mesh sieves, mixing, with the alcohol reflux 3 times of the determining alcohol 80% of 2.5kg, each 2 hours, merge extractive liquid, filtered, filtrate is adjusted to pH6 by NaOH solution, leave standstill, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, leave standstill, centrifugalize, supernatant after centrifugalize, the heating relative density be concentrated at 60 DEG C is the mastic of 1.20, take Pollen Typhae 32g, Poria 32g, Herba Hedyotidis Diffusae 27g, Rhizoma Polygoni Cuspidati 32g, Radix Coicis 27g, Herba Asteris Ageratoidis 32g, rabbit hair Artemisia 32g, Herba Hydrocotyles 22g, pulverize respectively, cross 40 mesh sieves, mix acquisition mixture, add the soak by water twice of 900g, each decoction 2 hours, filter respectively, merging filtrate, during dense 60 DEG C of filtrate, relative density is the mastic of 1.30, by the mastic mixing obtained, put into oven drying after mixing and obtain mixed powder, get 500g medicated powder, add 500g starch, be uniformly mixed, obtain powder 3.

Embodiment 4 oral liquid 1

Take Fructus Psoraleae 25g to pulverize, cross 40 mesh sieves, carry out CO ₂supercritical extraction, extracting pressure 27MPa, extraction temperature 70 DEG C, CO ₂flow is 5L/h, extraction time is 3h, obtain extractum shape extract, with the silica gel adsorption of granularity 200 order, petroleum ether carries out eluting, collect eluent, reclaim petroleum ether, obtain Fructus Psoraleae extract, take Radix Astragali 60g, Radix Ginseng 40g, Semen Euryales 25g, Radix Liriopes 25g, Rhizoma Polygonati 30g, Radix Salviae Miltiorrhizae 40g, Caulis Spatholobi 30g, Radix Morindae Officinalis 25g, Semen Alpiniae Katsumadai 30g, Ramulus et Folium Debregeasiae Edulis 20g, Herba Lamii Amplexicaulis 25g, Herba Euphorbiae Humifusae 25g and Cortex Phellodendri 30g, pulverize respectively, cross 40 mesh sieves, mixing, with the alcohol reflux 3 times of the determining alcohol 80% of 2.5kg, each 2 hours, merge extractive liquid, filtered, filtrate is adjusted to pH6 by NaOH solution, leave standstill, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, leave standstill, centrifugalize, supernatant after centrifugalize, the heating relative density be concentrated at 60 DEG C is the mastic of 1.20, take Pollen Typhae 30g, Poria 30g, Herba Hedyotidis Diffusae 25g, Rhizoma Polygoni Cuspidati 30g, Radix Coicis 25g, Herba Asteris Ageratoidis 30g, rabbit hair Artemisia 30g, Herba Hydrocotyles 20g, pulverize respectively, cross 40 mesh sieves, mix acquisition mixture, add the soak by water twice of 900g, each decoction 2 hours, filter respectively, merging filtrate, during dense 60 DEG C of filtrate, relative density is the mastic of 1.30, by the mastic mixing obtained, get mastic mixture 150g, add Mel 100g, sucrose 90g, sodium benzoate 3.0g and water appropriate, mixing, hydro-oxidation sodium test solution adjust pH to 5 ~ 6, add water to 1000ml, filter, embedding, sterilizing, obtain oral liquid 1.

Embodiment 5 oral liquid 2

Take Fructus Psoraleae 23g to pulverize, cross 40 mesh sieves, carry out CO ₂supercritical extraction, extracting pressure 27MPa, extraction temperature 70 DEG C, CO ₂flow is 5L/h, extraction time is 3h, obtain extractum shape extract, with the silica gel adsorption of granularity 200 order, petroleum ether carries out eluting, collect eluent, reclaim petroleum ether, obtain Fructus Psoraleae extract, take Radix Astragali 58g, Radix Ginseng 38g, Semen Euryales 23g, Radix Liriopes 23g, Rhizoma Polygonati 28g, Radix Salviae Miltiorrhizae 38g, Caulis Spatholobi 28g, Radix Morindae Officinalis 23g, Semen Alpiniae Katsumadai 28g, Ramulus et Folium Debregeasiae Edulis 18g, Herba Lamii Amplexicaulis 23g, Herba Euphorbiae Humifusae 23g and Cortex Phellodendri 28g, pulverize respectively, cross 40 mesh sieves, mixing, with the alcohol reflux 3 times of the determining alcohol 80% of 2.5kg, each 2 hours, merge extractive liquid, filtered, filtrate is adjusted to pH6 by NaOH solution, leave standstill, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, leave standstill, centrifugalize, supernatant after centrifugalize, the heating relative density be concentrated at 60 DEG C is the mastic of 1.20, take Pollen Typhae 28g, Poria 28g, Herba Hedyotidis Diffusae 23g, Rhizoma Polygoni Cuspidati 28g, Radix Coicis 23g, Herba Asteris Ageratoidis 28g, rabbit hair Artemisia 28g, Herba Hydrocotyles 18g, pulverize respectively, cross 40 mesh sieves, mix acquisition mixture, add the soak by water twice of 900g, each decoction 2 hours, filter respectively, merging filtrate, during dense 60 DEG C of filtrate, relative density is the mastic of 1.30, by the mastic mixing obtained, get mastic mixture 150g, add Mel 100g, sucrose 90g, sodium benzoate 3.0g and water appropriate, mixing, hydro-oxidation sodium test solution adjust pH to 5 ~ 6, add water to 1000ml, filter, embedding, sterilizing, obtain oral liquid 2.

Embodiment 6 oral liquid 3

Take Fructus Psoraleae 27g to pulverize, cross 40 mesh sieves, carry out CO ₂supercritical extraction, extracting pressure 27MPa, extraction temperature 70 DEG C, CO ₂flow is 5L/h, extraction time is 3h, obtain extractum shape extract, with the silica gel adsorption of granularity 200 order, petroleum ether carries out eluting, collect eluent, reclaim petroleum ether, obtain Fructus Psoraleae extract, take Radix Astragali 62g, Radix Ginseng 42g, Semen Euryales 27g, Radix Liriopes 27g, Rhizoma Polygonati 32g, Radix Salviae Miltiorrhizae 42g, Caulis Spatholobi 32g, Radix Morindae Officinalis 27g, Semen Alpiniae Katsumadai 32g, Ramulus et Folium Debregeasiae Edulis 22g, Herba Lamii Amplexicaulis 27g, Herba Euphorbiae Humifusae 27g and Cortex Phellodendri 32g, pulverize respectively, cross 40 mesh sieves, mixing, with the alcohol reflux 3 times of the determining alcohol 80% of 2.5kg, each 2 hours, merge extractive liquid, filtered, filtrate is adjusted to pH6 by NaOH solution, leave standstill, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, leave standstill, centrifugalize, supernatant after centrifugalize, the heating relative density be concentrated at 60 DEG C is the mastic of 1.20, take Pollen Typhae 32g, Poria 32g, Herba Hedyotidis Diffusae 27g, Rhizoma Polygoni Cuspidati 32g, Radix Coicis 27g, Herba Asteris Ageratoidis 32g, rabbit hair Artemisia 32g, Herba Hydrocotyles 22g, pulverize respectively, cross 40 mesh sieves, mix acquisition mixture, add the soak by water twice of 900g, each decoction 2 hours, filter respectively, merging filtrate, during dense 60 DEG C of filtrate, relative density is the mastic of 1.30, by the mastic mixing obtained, get mastic mixture 150g, add Mel 100g, sucrose 90g, sodium benzoate 3.0g and water appropriate, mixing, hydro-oxidation sodium test solution adjust pH to 5 ~ 6, add water to 1000ml, filter, embedding, sterilizing, obtain oral liquid 3.

Embodiment 7 clinical data

Physical data

Select the tumor patient of being in hospital in the court's internal medicine between year May in October, 2006 to 2012, all turn out to be malignant tumor late period through pathologic finding or CT or postoperatively accept chemotherapy person.Accept observer's totally 136 examples, wherein man 77 example, female 59 example; 36 ~ 80 years old age, average 53 years old.In 136 examples, pulmonary carcinoma 31 example, colon cancer 29 example, gastric cancer 22 example, the esophageal carcinoma 26 example, breast carcinoma 28 example, common drug is cyclophosphamide (CTX), methotrexate (MTX), amycin (ADM), epirubicin (EADM), mitomycin (MMC), cisplatin (DDP), carboplatin (CBP), etoposide (VP-16), 5-fluorouracil (5-FU), vinorelbine (NVB) etc.Above-mentioned case is divided into treatment group and matched group at random, each 68 examples.Two groups of sexes, age, protopathy and severe extents are basically identical, have comparability.Treatment group adds and takes traditional Chinese medicine after chemotherapy, and matched group is chemotherapy only.

Therapeutic Method

Treatment group starts to take Chinese medicine for 3 days before chemotherapy starts, to end of chemotherapy the 3rd day, and the Chinese medicine taken is powder 1 prepared by embodiment 1, and each serving with 2 times, each 200g, adopts warm water to take after mixing it with water.Chemotherapy coordinates that Western medicine is calm, antiemetic treatment simultaneously, method therefor and medicine identical with matched group.Matched group chemotherapy, chemotherapy rose the same day takes metoclopramide 10mg, every day 3 times; The quiet note of dexamethasone 5mg; The quiet note of hydrochloric acid Si Danxi ketone 8mg.End of chemotherapy drug withdrawal next day.If there is leukopenia, the drug for increasing white cells such as application granulocyte colony-stimulating factor (GOCSF).

Curative effect determinate standard

After end of chemotherapy the 3rd day, observe two groups of patients ' vomitings, abdominal distention, constipation with dry stool, diarrhoea, situation of change such as symptom score such as whole body fatigue and weakness, alopecia etc.By clinical symptoms without (non-evident sympton), light (mild symptoms or occur once in a while), in (time light during symptom heavy or be interrupted occur), heavy (symptom repeatedly occurs or occurs with main suit) degree count 0 point, 1 point, 2 points, 3 points respectively, accumulative score value, observe the change of its score value, and carry out statistical procedures.

Statistical method

This result of study all adopts the conjoint analysis of SPSS13.0 and DPS7.0 statistical software, carries out t inspection to the data obtained, and enumeration data adopts chi-square criterion, and P < 0.05 shows to have significant difference between group.

Result

In table 1.

Toxicity symptom score difference after table 1 liang group Chemotherapy of Tumor Patients )

As can be seen from Table 1, the change of nausea and vomiting before and after Drug therapy provided by the invention, abdominal distention, constipation with dry stool, diarrhoea, fatigue and weakness, alopecia degree score value is adopted to observe, and through statistical procedures, multinomial symptom has significantly or the improvement of highly significant, P<0.05.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (6)

1., for improving a medicine for toxicity after chemotherapy of tumors, it is characterized in that: crude drug is made up of the Radix Astragali, Radix Ginseng, Semen Euryales, Pollen Typhae, Fructus Psoraleae, Poria, Radix Liriopes, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati, Radix Morindae Officinalis, Semen Alpiniae Katsumadai, Radix Coicis, Herba Asteris Ageratoidis, Ramulus et Folium Debregeasiae Edulis, Herba Lamii Amplexicaulis, rabbit hair Artemisia, Herba Hydrocotyles, Herba Euphorbiae Humifusae and Cortex Phellodendri;

The weight of each crude drug is respectively Radix Astragali 55g ~ 65g, Radix Ginseng 35g ~ 45g, Semen Euryales 20g ~ 30g, Pollen Typhae 25g ~ 35g, Fructus Psoraleae 20g ~ 30g, Poria 25g ~ 35g, Radix Liriopes 20g ~ 30g, Rhizoma Polygonati 25g ~ 35g, Radix Salviae Miltiorrhizae 35g ~ 45g, Caulis Spatholobi 25g ~ 35g, Herba Hedyotidis Diffusae 20g ~ 30g, Rhizoma Polygoni Cuspidati 25g ~ 35g, Radix Morindae Officinalis 20g ~ 30g, Semen Alpiniae Katsumadai 25g ~ 35g, Radix Coicis 20g ~ 30g, Herba Asteris Ageratoidis 25g ~ 35g, Ramulus et Folium Debregeasiae Edulis 15g ~ 25g, Herba Lamii Amplexicaulis 20g ~ 30g, rabbit hair Artemisia 25g ~ 35g, Herba Hydrocotyles 15g ~ 25g, Herba Euphorbiae Humifusae 20g ~ 30g and Cortex Phellodendri 25g ~ 35g.

2. medicine as claimed in claim 1, it is characterized in that: the weight of each crude drug is respectively Radix Astragali 58g ~ 62g, Radix Ginseng 38g ~ 42g, Semen Euryales 23g ~ 27g, Pollen Typhae 28g ~ 32g, Fructus Psoraleae 23g ~ 27g, Poria 28g ~ 32g, Radix Liriopes 23g ~ 27g, Rhizoma Polygonati 28g ~ 32g, Radix Salviae Miltiorrhizae 38g ~ 42g, Caulis Spatholobi 28g ~ 32g, Herba Hedyotidis Diffusae 23g ~ 27g, Rhizoma Polygoni Cuspidati 28g ~ 32g, Radix Morindae Officinalis 23g ~ 27g, Semen Alpiniae Katsumadai 28g ~ 32g, Radix Coicis 23g ~ 27g, Herba Asteris Ageratoidis 28g ~ 32g, Ramulus et Folium Debregeasiae Edulis 18g ~ 22g, Herba Lamii Amplexicaulis 23g ~ 27g, rabbit hair Artemisia 28g ~ 32g, Herba Hydrocotyles 18g ~ 22g, Herba Euphorbiae Humifusae 23g ~ 27g and Cortex Phellodendri 28g ~ 32g.

3. medicine as claimed in claim 1 or 2, is characterized in that: the weight of each crude drug is respectively Radix Astragali 60g, Radix Ginseng 40g, Semen Euryales 25g, Pollen Typhae 30g, Fructus Psoraleae 25g, Poria 30g, Radix Liriopes 25g, Rhizoma Polygonati 30g, Radix Salviae Miltiorrhizae 40g, Caulis Spatholobi 30g, Herba Hedyotidis Diffusae 25g, Rhizoma Polygoni Cuspidati 30g, Radix Morindae Officinalis 25g, Semen Alpiniae Katsumadai 30g, Radix Coicis 25g, Herba Asteris Ageratoidis 30g, Ramulus et Folium Debregeasiae Edulis 20g, Herba Lamii Amplexicaulis 25g, rabbit hair Artemisia 30g, Herba Hydrocotyles 20g, Herba Euphorbiae Humifusae 25g and Cortex Phellodendri 30g.

4. medicine as claimed in claim 1 or 2, is characterized in that: described medicine can be sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, granule, pill, powder, sublimed preparation, solution or injection.

5. medicine as claimed in claim 1 or 2, is characterized in that: described medicine can be oral liquid and powder.

6. medicine as claimed in claim 1 or 2, it is characterized in that: can add medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier is one or more in starch, sucrose, Mel, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, Tween 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Pulvis Talci, magnesium stearate, calcium stearate.