CN103041258B - Chinese materia medica preparation for curing respiratory tract infection with poor appetite of children - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating respiratory tract infection in children with anorexia. Scutellaria baicalensis, Gansong, kaempferen, asarum, dogwood, hawthorn, gallinacea. The present invention is aimed at children's immature body, for the abnormal cold and warm, exogenous pathogens taking advantage of the deficiency, exogenous pathogenic pathogens, easy to transform heat, and repeated infections. Antiviral, antipyretic and anti-inflammation, enhance body immunity; and safe, less toxic and side effects, easy to use, short curing time, difficult to relapse after curing.

Description

Traditional Chinese Medicine Preparation for Treating Respiratory Tract Infection in Children with Poor Anorexia

technical field

The invention relates to a medical preparation containing raw materials derived from plants, animals or minerals, in particular to a traditional Chinese medicine preparation for treating respiratory tract infection in children with anorexia.

Background technique

Recurrent respiratory tract infection in children is a common clinical disease and frequently-occurring disease. RRTI is a common disease and frequently-occurring disease that has been gradually paid attention to by scholars at home and abroad in recent years. Modern medicine believes that the exact pathogenesis is not completely clear, and it is the result of the combined effects of various factors. Low immune function is considered to be one of the important causes of the disease.

According to the theory of traditional Chinese medicine, the key to the pathogenesis of relapsing children is "not excess evils but positive deficiency". In recent years, research on this has been developed, and it is believed that RRTI is caused by deficiency of both lung and spleen, imbalance of yin and yang, and weakness of Wei and yang. Most of the western medicines will harm the immature body of young children. Therefore, based on the theory of traditional Chinese medicine, according to the physical characteristics of children's immature yin and yang, the prescriptions are precise and effective. Traditional Chinese medicine believes that the deficiency of lung, spleen and kidney qi is the key to its pathogenesis. It is said in "Suwen Wuzang Shengcheng Chapter": "All qi belongs to the lung." The lung governs qi, controls breathing, and plays an important role in regulating the whole body . Insufficient qi and blood in the lungs means insufficient defensive qi, so spontaneous sweating and easy exogenous pathogenic factors. In children, the spleen is often deficient, the spleen and stomach are weak, the circulation is abnormal, the biochemical source of qi and blood is lacking, the soil does not produce metal, the lung qi is also deficient, and it is easy to cause exogenous pathogenic factors. Repeated exogenous diseases, long-term illness damage the kidney, the kidney is the root of Yuanyang, and deficiency of kidney qi can lead to insufficient lung and spleen. Form a vicious circle. It can be seen that the treatment of this disease should benefit the lung, invigorate the spleen, invigorate the kidney, replenish qi and strengthen the exterior. Focus on nourishing qi, sufficient kidney qi, and healthy spleen and stomach, then the soil will be cultivated to produce gold, and the function of gold and water will return to normal.

According to the diagnostic criteria for recurrent respiratory tract infection (RRTI) revised by the National Pediatric Respiratory Disease Academic Conference in April 1987: age 0-2 years old, upper respiratory tract infection 7 times/year, lower respiratory tract infection 3 times/year; age 3-5 years old, Upper respiratory tract infection 6 times/year, lower respiratory tract infection 2 times/year; age 6-14 years old, upper respiratory tract infection 5 times/year, lower respiratory tract infection 2 times/year. The second upper respiratory infection is at least 7 days away from the first. If the number of upper respiratory tract infections is not enough, the number of lower respiratory tract infections can be added, and vice versa. Respiratory tract infection is one of the most common diseases in children, especially in winter and spring. The main cause of respiratory tract infection is virus, and a few are caused by bacteria or Mycoplasma pneumoniae. Mild symptoms are mainly runny nose, sneezing, slight cough, sore throat, fatigue, loss of appetite, and may have low-grade fever. , a small number may have febrile convulsions. The prognosis is generally good, but frail patients can cause complications such as otitis media, cervical lymphadenitis, and retropharyngeal wall abscess, and very few cases can induce viral myocarditis. If the inflammation spreads downward, it can cause bronchitis or pneumonia. Bacterial infections are often combined on the basis of viral infections. The current treatment method generally adopts antibiotic therapy, with unlimited blindly dripping, which will not only cause harm to the human body, but also increase the cost of treatment, and double the use of antibiotics in the future when infection and fever occur, resulting in a vicious circle, resulting in a lack of immunity, and the treatment effect is often not satisfactory. People are satisfied.

The treatment of susceptible children in modern medicine mainly includes zinc supplementation, calcium supplementation, vitamin supplementation, gamma globulin, thymosin, transfer factor, etc., in order to improve the immunity of children. However, there is a lack of targeted treatment for individual constitutions, and the effect is not satisfactory. Prevention and treatment of recurrent respiratory tract infection with Yigan prescription avoids the toxic and side effects caused by long-term use of western medicine. So there is an urgent need for a Chinese medicine preparation that has little toxic and side effects, quick curative effect, and is suitable for the prevention and treatment of recurrent respiratory tract infections in children.

Contents of the invention

Recurrent respiratory infections in children are often caused by abnormal cold and heat, and exogenous evils take advantage of the deficiency. The treatment of susceptible children in Western medicine mainly includes zinc supplementation, calcium supplementation, vitamin supplementation, gamma globulin, thymosin, transfer factor, etc. to improve the immunity of children. force. However, there is a lack of targeted treatment for individual constitutions, and the effect is not ideal; in order to solve the above technical problems, the present invention provides a traditional Chinese medicine theory based on the physical characteristics of infantile yin and immature yang. A traditional Chinese medicine preparation for children with recurrent respiratory tract infection, which is common and has a simple and convenient preparation method.

A traditional Chinese medicine preparation for treating respiratory tract infection in children, the parts by weight of various raw materials in the preparation are: notopterygium 10-15 parts, citrus aurantium 10-15 parts, kudzu root 10-15 parts, atractylodes 10-15 parts, jing 10-15 parts of mustard ear, 10-15 parts of cicada slough, 10-15 parts of Poria cocos, 10-15 parts of astragalus, 10-15 parts of Angelica dahurica, 10-15 parts of Radix Ophiopogon japonicus, 10-15 parts of Fangfeng, 10-15 parts of Scutellaria baicalensis, 10-15 parts of Gansong, 10-15 parts of Kaempferia, 10-15 parts of Asarum, 10-15 parts of Cornus officinalis.

The parts by weight of various raw materials in the preparation can be preferably: 10-12 parts of notopterygium, 10-15 parts of citrus aurantii, 10-15 parts of kudzu root, 10-15 parts of herb, 10-15 parts of nepeta, 10-15 parts of cicada slough 10-15 parts, Poria 10-12 parts, Astragalus 10-12 parts, Angelica dahurica 10-15 parts, Ophiopogon japonicus 10-12 parts, Fangfeng 10-15 parts, Scutellaria baicalensis 10-15 parts, Gansong 10-12 parts, Kaempferia 10-15 parts, Asarum 10-15 parts, Cornus officinalis 10-15 parts.

The parts by weight of various raw materials in the preparation can also be preferably: 12-15 parts of notopterygium, 10-15 parts of citrus aurantii, 10-15 parts of kudzu root, 10-15 parts of atractylodes rhizome, 10-15 parts of nepeta, 12-15 parts of cicada slough, 12-15 parts of Poria, 10-15 parts of Astragalus, 12-15 parts of Angelica dahurica, 10-15 parts of Ophiopogon japonicus, 12-15 parts of Fangfeng, 10-15 parts of Scutellaria baicalensis, 12-15 parts of Gansong, Kaempfer 10-15 parts, Asarum 10-15 parts, Cornus officinalis 10-12 parts.

As for the traditional Chinese medicine preparation for treating children with respiratory tract infection, 10-15 parts of dandelion and 10-15 parts of honeysuckle are added to children with sore throat and enlarged tonsils.

As for the traditional Chinese medicine preparation for treating children with respiratory tract infection, 10-15 parts of forsythia and 10-15 parts of Radix Radix are added to children with fever and high fever.

For the traditional Chinese medicine preparation for treating respiratory tract infection in children, 10-15 parts of Hawthorn and 10-15 parts of Gallus chinensis will be added when the child suffers from anorexia and does not digest food.

The ratio of parts by weight of various raw materials in the preparation can be: 12-15 parts of notopterygium, 10-15 parts of Citrus aurantii, 10-15 parts of kudzu root, 12-15 parts of atractylodes rhizome, 10-15 parts of nepeta, 10-15 parts of cicada slough 10-15 parts, Poria 10-15 parts, Astragalus 10-15 parts, Angelica dahurica 12-15 parts, Ophiopogon japonicus 10-15 parts, Fangfeng 12-15 parts, Scutellaria baicalensis 12-15 parts, Gansong 10-15 parts, Kaempferia 12-15 parts, 10-15 parts of asarum, 10-15 parts of dogwood, 10-15 parts of hawthorn, 10-15 parts of Gallus gallis.

The weight-to-number ratio of various raw materials in the preparation can also be: 10-15 parts of notopterygium, 10-15 parts of Citrus aurantii, 10-12 parts of kudzu root, 10-12 parts of atractylodes rhizome, 10-15 parts of nepeta panicle, cicada slough 10-15 parts, Poria 10-15 parts, Astragalus 10-15 parts, Angelica dahurica 10-15 parts, Ophiopogon japonicus 10-15 parts, Fangfeng 10-12 parts, Scutellaria baicalensis 10-15 parts, Gansong 10-15 parts, Kaempferia 10-15 parts, 10-15 parts of asarum, 10-15 parts of dogwood, 10-12 parts of hawthorn, 10-12 parts of Gallus gallis.

The weight-to-number ratio of various raw materials in the preparation can also be: 10-12 parts of notopterygium, 10-15 parts of Citrus aurantii, 12-15 parts of kudzu root, 10-12 parts of herb, 10-15 parts of nepeta, 10-15 parts of cicada slough 12-15 parts, Poria 10-15 parts, Astragalus 10-15 parts, Angelica dahurica 12-15 parts, Ophiopogon japonicus 10-15 parts, Fangfeng 10-12 parts, Scutellaria baicalensis 10-15 parts, Gansong 10-12 parts, Kaempferia 10-15 parts, 10-15 parts of asarum, 10-15 parts of dogwood, 10-15 parts of hawthorn, 10-15 parts of Gallus gallis.

The ratio of parts by weight of various raw materials in the preparation can be: 10-15 parts of notopterygium, 10-12 parts of Citrus aurantium, 10-15 parts of kudzu root, 10-15 parts of atractylodes rhizome, 10-15 parts of nepeta, 10-15 parts of cicada slough 10-15 parts, Poria 12-15 parts, Astragalus 12-15 parts, Angelica dahurica 10-12 parts, Ophiopogon japonicus 10-15 parts, Fangfeng 10-15 parts, Scutellaria baicalensis 10-15 parts, Gansong 10-12 parts, Kaempferia 10-15 parts, 10-15 parts of asarum, 10-12 parts of dogwood, 10-15 parts of hawthorn, 10-15 parts of Gallus gallis.

For the traditional Chinese medicine preparation for treating respiratory tract infection in children, 10-15 servings of Baibu and 10-15 servings of Anemarrhena anemarrhena are added when the child is accompanied by excessive phlegm and cough.

In order to solve the above-mentioned technical problems, the present invention also provides a preparation method of a traditional Chinese medicine preparation for treating infantile respiratory tract infection with anorexia.

a. Select the raw medicinal materials except asarum, notopterygium and atractylodes atractylodes, and make them into clean medicinal materials for later use;

b. Take each herbal medicinal material and decoct it with water for three times, then concentrate under reduced pressure;

c. Extract asarum, notopterygium and atractylodes atractylodes by steam distillation to obtain crystals

d. Put Asarum, notopterygium and herb crystals into the concentrated solution, add dextrin to sterilize and make medicine.

In the step b, each raw medicinal material except asarum, notopterygium and herb can be decocted three times with water, adding 5 to 10 times the amount of water each time, soaking, decocting, and filtering; discarding the medicinal residues, combining the filtrate, Evaporate and concentrate under reduced pressure to a concentrated solution with a relative density of 1.10 to 1.15 at a relative density of 60 to 70°C, let it stand for 24 hours, and take the supernatant.

In the step d, the concentrated solution can be sterilized with CO60, the irradiation dose is 8k, dextrin is added, and then vacuum-frozen and sealed.

In order to solve the above-mentioned technical problems, the present invention also provides a preparation method of a traditional Chinese medicine preparation for treating infantile respiratory tract infection with poor appetite. The preparation method of the traditional Chinese medicine preparation dosage form is a tablet comprising:

a. Put Asarum, Notopterygium and Atractylodes atractylodes into the distillation pot and steam distill them into essential oil;

b. Then take the remaining raw material drug and soak it in water, heat extract twice, and form an extract, which is component 1;

c. The dregs are extracted with ethanol once, concentrated and filtered to obtain an extract, which is component 2;

d. Concentrate the above two extracts into a paste, pour into the essential oil obtained in step a, add starch and press into tablets.

In the step b, the raw material drug can be taken and soaked in 5-10 times the amount of water for 1-2 hours, heated and extracted twice for 1-2 hours each time, the supernatant is removed, the extracts are combined, and filtered through 100-120 mesh After passing through an ultrafiltration column with a cut-off molecular weight of 5000-10000, the ultrafiltrate is concentrated under reduced pressure to an extract with a relative density of 1.38 at 80°C, heated and concentrated for 30 to 45 minutes, concentrated to an extract, and left to stand Standby and become component 1; in the step c, put the medicinal residues extracted by water into 10 times the amount of ethanol, heat and reflux for extraction once, the extraction time is 1-2 hours, filter through 100-120 mesh, and then After ultrafiltration through an ultrafiltration column with a cut-off molecular weight of 5,000-10,000, the ultrafiltrate is concentrated under reduced pressure to an extract with a relative density of 1.38 at 80°C, heated and concentrated for 30 to 45 minutes, concentrated to an extract, and left to stand for later use. Component 2.

The present invention is aimed at children's immature body, for the abnormal cold and warm, exogenous pathogens taking advantage of the deficiency, exogenous pathogenic pathogens, easy to transform heat, and repeated infections. Antiviral, antipyretic and anti-inflammation, enhance body immunity; and safe, less toxic and side effects, easy to use, short curing time, difficult to relapse after curing. Compared with the prior art, this technology has the advantages of convenient administration, easy manufacture of medicament, low cost, etc., and can create better social value and economic benefits.

Detailed ways

According to the theory of traditional Chinese medicine, the key to the pathogenesis of relapsing children is "not excess evils but positive deficiency". In recent years, research on this has been developed, and it is believed that RRTI is caused by deficiency of both lung and spleen, imbalance of yin and yang, and weakness of Wei and yang. Most of the western medicines will harm the immature body of young children. Therefore, based on the theory of traditional Chinese medicine, according to the physical characteristics of children's immature yin and yang, the prescriptions are precise and effective. Traditional Chinese medicine believes that the deficiency of lung, spleen and kidney qi is the key to its pathogenesis. It is said in "Suwen Wuzang Shengcheng Chapter": "All qi belongs to the lung." The lung governs qi, controls breathing, and plays an important role in regulating the whole body . Insufficient qi and blood in the lungs means insufficient defensive qi, so spontaneous sweating and easy exogenous pathogenic factors. In children, the spleen is often deficient, the spleen and stomach are weak, the circulation is abnormal, the biochemical source of qi and blood is lacking, the soil does not produce metal, the lung qi is also deficient, and it is easy to cause exogenous pathogenic factors. Repeated exogenous diseases, long-term illness damage the kidney, the kidney is the root of Yuanyang, and deficiency of kidney qi can lead to insufficient lung and spleen. Form a vicious circle. It can be seen that the treatment of this disease should benefit the lung, invigorate the spleen, invigorate the kidney, replenish qi and strengthen the exterior. Focus on nourishing qi, sufficient kidney qi, and healthy spleen and stomach, then the soil will be cultivated to produce gold, and the function of gold and water will return to normal.

Traditional Chinese medicine believes that children's viscera are delicate, their skin barriers are not tight, their external defense functions are not solid, and they don't know how to adjust themselves to cold and warm, often due to sudden changes in the climate in the four seasons, abnormal cold and warm, external evils take advantage of the deficiency and enter the hair as the main disease; "The body of pure yang" is "yang is always surplus, and yin is always insufficient". Exogenous pathogenic factors cause pathogenic factors and are easy to transform into heat. Upper respiratory tract infection is a common and frequently-occurring disease in pediatrics, accounting for 70% to 80% of pediatric outpatient visits. Its clinical manifestations often include fever, nasal congestion, runny nose, cough, expectoration, and sore throat. : loss of appetite, vomiting, diarrhea, abdominal pain, etc., more than 90% of its pathogenic microorganisms are caused by viruses, and other microorganisms such as bacteria and mycoplasma. Therefore, in the treatment, not only antiviral and antibacterial drugs are needed, but also related drugs for anti-vomiting, anti-diarrheal, cough-relieving, phlegm-reducing, and digestion-promoting.

Recurrent respiratory tract infection belongs to the category of deficiency syndrome in traditional Chinese medicine, which is responsible for the deficiency of lung and spleen, causing internal disturbance of deficiency fire and weak appearance of health. The lung governs the appearance of the whole body, the spleen and stomach are the foundation of the acquired constitution, the source of qi and blood biochemistry, the spleen and stomach are in good circulation, the qi and blood are strong, and the flow of qi is smooth, so that the five internal organs can be peaceful and all diseases will not occur. The incidence of this disease is relatively high, accounting for more than 60% of outpatients. Traditional Chinese medicine believes that this disease is mainly caused by wind pathogens, and it is an exogenous disease caused by unhealthy qi in the four seasons. Because children's internal organs are delicate, their skin is thin and their defenses are weak, they are prone to this disease. Young and frail children are more likely to suffer from this disease. In children with cold and high fever, there are few cases of pure wind-cold or wind-heat, but most of them are external cold and internal heat or "cold pack heat". If only pungent and warm are used to dissipate, the external cold will go away, but the internal heat will re-emerge; if only pungent and cool are used to relieve, the external cold will love, and the internal heat will have no way out. Practice has proved that combining pungent temperature with pungent cold can open the Xuanfu and clear the accumulated heat; supplemented by pivoting and lifting, the heat can be drawn out, supplemented with sour and sweet to transform yin, harmonize the camp and expel the heat, and the place that is not affected by evil is safe first. , in order to "complete its merits in one shot".

Recurrent respiratory tract infection in children is a common clinical disease and frequently-occurring disease. Traditional Chinese medicine believes that the deficiency of lung, spleen and kidney qi is the key to its pathogenesis. "Su Wen·Wu Zang Cheng Sheng Pian" says: "All qi belongs to the lung." Breathing plays an important role in regulating the Qi mechanism of the whole body. Insufficient qi and blood in the lungs means insufficient defensive qi, so spontaneous sweating and easy exogenous pathogenic factors. In children, the spleen is often deficient, the spleen and stomach are weak, the circulation is abnormal, the biochemical source of qi and blood is lacking, the soil does not produce metal, the lung qi is also deficient, and it is easy to cause exogenous pathogenic factors. Repeated exogenous diseases, long-term illness damage the kidney, the kidney is the root of Yuanyang, and deficiency of kidney qi can lead to insufficient lung and spleen. Form a vicious circle. It can be seen that the treatment of this disease should benefit the lung, invigorate the spleen, invigorate the kidney, replenish qi and strengthen the exterior. Focus on nourishing qi, sufficient kidney qi, and healthy movement of the spleen and stomach, so that the earth can be cultivated to produce gold, and the gold and water can grow together.

Prescription description: Fangfeng enters the Taiyang and Shaoyin meridians in the prescription, and is a meridian-inducing medicine; Notopterygium warms the lungs, clears phlegm and promotes Qi, dissipates stagnation, dredges collaterals, and relieves pain; Nepeta, cicada sloughs, relieves wind, removes heat, and reduces swelling; Dandelion reduces swelling and relieves pain; Radix Puerariae promotes clearness and clarity; Poria cocos dries dampness and resolves phlegm and invigorates the spleen; dredges lung qi; Diuretic and detoxification, invigorating the spleen and nourishing qi, Scutellaria baicalensis reducing fire and detoxifying; Gallinarum appetizer and eliminating food, kudzu root clearing heat and eliminating troubles, hawthorn and gallinaceous gold invigorating the spleen and eliminating food are good medicines for anorexia and indigestion; Radix Radix and Forsythia detoxify sweat. The whole prescription has the functions of clearing away heat and detoxification, regulating the spleen and stomach, and regulating the movement of qi.

Radix Astragali is mainly used to invigorate deficiency, which can invigorate qi and solidify the exterior, diuretic and relieve toxins, drain pus, astringe sores and promote granulation. It is used for those with deficiency of Qi and blood, invagination of sores, pus that does not ulcerate or persists for a long time. Astragalus has a very good function of detoxifying and promoting granulation, that is, abscesses that have not healed for a long time suppurate and promote granulation. Modern medical research shows that astragalus contains a variety of antibacterial active ingredients, and can enhance the body's immune function, so it can also be used to prevent the occurrence of certain infectious diseases. "Materia Medica Fengyuan" contains: "Astragalus can nourish the deficiency of the five internal organs, control the stringy pulse and spontaneous sweating, relieve Yin fire, and remove lung heat. If there is no sweating, it will stop, and if there is sweating, it will stop." It is a good medicine for improving resistance and preventing diseases. It has a good effect on enriching blood and regulating menstruation especially for women.

Radix Puerariae relieves the surface and reduces fever, promotes body fluid, relieves rash, promotes yang and relieves diarrhea. For exogenous fever and headache, high blood pressure and neck pain, thirst, thirst, impervious measles, dysentery, and diarrhea. "Compendium of Materia Medica" contains: Radix Puerariae, cool in nature, flat in breath, sweet in taste, has the functions of clearing heat, reducing fire, and detoxifying. Modern medical research shows that puerarin, an isoflavone compound in kudzu root, has certain curative effects on hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular diseases. Elevate Yang Qi, quench thirst and relieve diarrhea Pueraria lobata Qingqing Sheng San, the medicinal properties are enhanced, Liu lifts Yang Qi, encourages the body to rise in righteousness, and distributes body fluid. Promote spleen and stomach to clear yang air and quench thirst, stop diarrhea and dysentery. Therefore, it is often used to treat diseases such as internal heat and thirst.

Schizonepetae pungent, slightly warm. Return lung, Liver Channel. Disperses the exterior and disperses the wind, clears the rash. For colds, headaches, measles, rubella, sores. Stir-fried charcoal treats blood in the stool, metrorrhagia, postpartum haemorrhage. Schizonepeta, a medicine, has the effect of dispelling wind and relieving the exterior surface when used raw, and it is used to stop bleeding when fried with charcoal. With Fangfeng, notopterygium, to treat wind-cold syndrome; with Yinhua, Forsythia, mint, to treat wind-heat syndrome; with raw gypsum, to treat wind-heat headache; with burdock, Poria, and raw licorice, to treat sore throat; with Sophora japonica Charcoal, treats blood in the stool; with Rhizoma Imperatae, treats epistaxis. Both nepeta and perilla can produce sweat and relieve the surface, but perilla has a strong ability to disperse cold, and it is more effective in regulating qi, while nepeta is more powerful in dispelling wind, and it is more effective in blood, and charcoal can stop bleeding. Therefore, perilla is often used in Qi-regulating prescriptions, and Schizonepeta is often used in blood-regulating medicines.

Cicada sloughs sweet, cold. Return lung, Liver Channel. Function: dispelling wind and removing heat, relieving sore throat, clearing rash, removing nebula, relieving spasm. For wind-heat cold, sore throat, hoarseness, opaque measles, rubella itching, convulsions and convulsions, and tetanus. It is used for diseases such as exogenous wind-heat, fever and chills, cough, rubella, and itchy skin. Cicada slough has the effect of evacuating wind-heat, and it is often used in conjunction with mint for wind-heat symptoms; it also has the function of dispelling wind and relieving itching for rubella itching.

Anti-flavor pungent, sweet, slightly warm in nature. Return bladder, liver, spleen channel. Expelling wind and relieving exterior syndrome, eliminating dampness and relieving pain, relieving spasm. Indications of external syndrome, rubella itching, rheumatic arthralgia, tetanus. For cold headache, rubella pruritus. For wind-cold exterior syndrome, headache and body pain, aversion to wind and cold, it is often compatible with nepeta, notopterygium, and solitary; for exogenous rheumatism, headache, heavy body and limb pain, it is used in the same way as notopterygium and ligusticum; for rubella and itching, it is more compatible Sophora flavescens, nepeta, angelica, etc.

Banlangen has obvious effects of clearing away heat and cooling blood, antiviral and antibacterial in clinical practice, and its dosage is large, which can be called the most of Chinese patent medicines. The research results show that Banlangen has a significant effect of clearing the body of pyrogens that can cause body temperature to rise. "Classification of Herbal Medicine" contains: "Relieves all poisons and evil sores, disperses toxins and relieves fire." It is cheap and has few toxic and side effects. It is a popular medicine for clearing away heat and detoxification.

"Compendium of Materia Medica" contains "Honeysuckle is good at detoxification, so it can treat carbuncle, swollen poison, sore and ringworm...". Since ancient times, honeysuckle is often used to clear away heat and detoxify, treat febrile disease fever, heat-toxin bloody dysentery, carbuncle and other diseases. Modern pharmacological studies have shown that honeysuckle has antibacterial, antiviral, anti-inflammatory, antipyretic, and immune-regulating functions. Traditional Chinese medicine believes that honeysuckle is cold in nature, sweet in taste, and calm in air. boils and other diseases. And it has the function of spreading and dispelling. Honeysuckle has a strong heat-clearing and detoxifying effect, and is commonly used in surgery.

Scutellaria baicalensis has heat-clearing and damp-drying, cooling blood and anti-abortion, detoxification effects. Indications for febrile disease, upper respiratory tract infection, lung-heat cough, damp-heat jaundice, pneumonia, dysentery, hemoptysis, red eyes, restless fetus, high blood pressure, carbuncle, swollen boils and other diseases. The clinical application of Scutellaria baicalensis is better than that of Coptis chinensis, and it does not produce drug resistance. Bitter, cold. Return lung, gallbladder, spleen, large intestine, small intestine channel. Clearing away heat and dampness, purging fire and detoxifying, stopping bleeding, preventing miscarriage, lowering blood pressure. It is used for chest tightness and nausea due to damp-warm and summer-heat, fullness due to damp-heat, dysentery, jaundice, cough due to lung-heat, high fever and polydipsia, vomiting of blood-heat, carbuncle sores, restless fetal movement.

Forsythia bitter, slightly cold. Return lung, heart, small intestine channel. Function is heat-clearing and toxic substances removing, reducing swelling and dissipating stagnation. For carbuncle, scrofula, breast carbuncle, erysipelas, wind-heat cold, febrile disease at the onset, warm-heat enters the camp, high fever and polydipsia, coma and spots, heat-drenched urine retention. The medicinal part of forsythia is mainly the fruit. Its husk is the "Qiao" in "Qinqiao Jiedu Pills". Contains forsythol, coumarin, oleanolic acid, saponins, vitamin P, etc. It has the effects of clearing away heat, detoxifying, dispelling stagnation and draining pus. Indications for warm heat, sores, scrofula, erysipelas, rash, influenza, decocted with fruit water, or added to prescriptions. Commonly used for wind-heat and cold. Nature, flavor and function: Traditional Chinese medicine tastes bitter and slightly cold in nature. Heat-clearing and toxic substances removing, stagnation-dispelling and swelling-reducing. Mongolian medicine is bitter in taste and cool in nature. Qing "Association Day", antidiarrheal. Indications: Traditional Chinese medicine is used to treat the early onset of fever, wind-heat cold, fever, upset, sore throat, macule, erysipelas, scrofula, carbuncle sores, acute nephritis, and stranguria. Mongolian medicine treats jaundice, intestinal tingling, "Xie Ri" disease, and intestinal fever. "Shen Nong's Materia Medica": main cold and heat, rat flaccidity, scrofula, carbuncle, malignant sore, goiter, stagnation of heat, poisonous poison.

Herba Fructus is sweet in nature, bitter, tepor. Return lung meridian. Functions and indications Moistening the lungs, lowering qi, relieving cough, and killing parasites. For chronic cough, tuberculosis cough, pertussis; moistening lung and relieving cough: for chronic cough, such as acute and chronic bronchitis, whooping cough and tuberculosis. With ephedra velvet and almonds to treat children with wind-cold cough and asthma; with aster, fritillary, and cold water stone to treat children with lung-heat cough.

Hawthorn, sliced and dried, put it in a wok and stir-fry until the outside is burnt brown and the inside is yellowish brown, sprayed with water, taken out and dried in the sun, it is burnt hawthorn. Taking hawthorn orally can increase digestive enzymes, promote fat decomposition and digestion, and is particularly effective for those who eat meat or eat too much greasy food, such as abdominal fullness, belching, lack of appetite, abdominal pain, and diarrhea. In addition, modern drug experiments have shown that hawthorn has a slow and long-lasting effect of lowering blood pressure, can also lower cholesterol and triglycerides, prevent atherosclerosis, and can also relax coronary arteries, increase myocardial contractility, and fight arrhythmia. Therefore, it is beneficial to prevent and treat hypertension, hyperlipidemia, arteriosclerosis and coronary heart disease.

The chicken is golden sweet, cold. Return spleen, stomach, small intestine, urinary bladder channel. Dispelling food and invigorating the stomach, astringent essence stops nocturnal emission. Chicken gold contains gastric hormones, keratin, amino acids, and trace amounts of pepsin and amylase. After oral administration of chicken gold powder, the secretion of gastric juice, acidity and digestion power are all increased, gastric motility is strengthened, and gastric emptying is accelerated. Its acid extract or decoction can accelerate the elimination of radioactive strontium from urine.

Poria cocos is sweet, light, flat. Guixin, lung, spleen, kidney channel. Function diuretic diuresis, invigorating the spleen and tranquilizing the heart. For edema, oliguria, dizziness and palpitation due to phlegm and retention, insufficiency of the spleen, lack of food, loose stool and diarrhea, restlessness, palpitation and insomnia. Expelling dampness and diuresis, benefiting the spleen and stomach, calming the mind and calming the nerves. Control dysuria, edema and fullness, phlegm retention and cough, vomiting, diarrhea, spermatorrhea, stranguria, palpitations, and forgetfulness. "The Classic" contains it: "The main chest and hypochondrium rebellious qi, anxiety, fear, evil and fear, knot pain in the heart, cold and heat, irritability, coughing, dry mouth and tongue, and urination." "Bie Lu": "Stopping Thirst, sleepiness, big belly, dripping, phlegm in the diaphragm, edema and nodules. Opens the chest and viscera, regulates visceral qi, cuts down kidney evils, grows yin, replenishes energy, protects the mind and keeps the center." "Theory of Medicine": "Appetizing , anti-vomiting, good peace of mind. Control lung flaccidity and phlegm. Treat children with convulsions and epilepsy, confidant distension, and women with hot stranguria."

Notopterygium dispelling exterior cold; expelling rheumatism; sharpening joints; relieving pain. Main exogenous wind-cold; headache without sweating; mimeograph cold-damp arthralgia; Fengshui edema; sore swollen toxin. For impotence and nocturnal emission, enuresis and frequent urination, cold pain in the waist and knees, asthma due to kidney deficiency, diarrhea at dawn; external use for treating vitiligo and alopecia areata. Relieve the exterior and dispel cold, expelling wind and dampness, relieving pain. For diseases such as exogenous wind-cold, aversion to cold and fever, headache and body pain. This product has a strong effect of dispelling wind-cold and relieving pain. It is often used with Fangfeng, Angelica dahurica, Asarum, etc., such as Jiuweiqianghuo Decoction. "Rihuazi Materia Medica": "Cure all wind and qi, muscle and bone spasms, weak limbs, head rotation, red eyes and eyes, and water vapor in the beam, five labors and seven injuries, depletion of air-conditioning, sore joints, and benefit the five internal organs. "

Radix Puerariae relieves the surface and reduces fever, promotes body fluid, relieves rash, promotes yang and relieves diarrhea. For exogenous fever and headache, high blood pressure and neck pain, thirst, thirst, impervious measles, dysentery, and diarrhea. "Compendium of Materia Medica" contains: Radix Puerariae, cool in nature, flat in breath, sweet in taste, has the functions of clearing heat, reducing fire, and detoxifying. Modern medical research shows that puerarin, an isoflavone compound in kudzu root, has certain curative effects on hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular diseases. Li Shizhen, a famous medical scientist in the Ming Dynasty, conducted systematic research on Pueraria lobata, and believed that the stems, leaves, flowers, fruits and roots of Pueraria lobata can be used as medicine. He recorded in "Compendium of Materia Medica": "Ge, sweet, pungent, flat, non-toxic, and mainly cures: diabetes, body heat, vomiting, numbness, yin qi, and detoxification."

Atractylodes Rhizoma Atractylodis Drains Dampness and Strengthens the Spleen, Dispels Wind and Cold, Improves Eyesight. For abdominal distension, diarrhea and edema, beriberi flaccidity, rheumatic arthralgia, anemofrigid cold, night blindness. Mainly dampness traps the spleen and stomach; lassitude and lying down; abdominal distension; loss of appetite; vomiting and diarrhea; phlegm retention; damp swelling; surface syndrome with dampness; severe pain in the head and body; arthralgia syndrome warm in nature; severe soreness in the limbs; flaccidity. Used for damp-restriction of the spleen and stomach, fullness in the abdomen, cold-damp leucorrhea, damp-febrile disease and betting of damp-heat, swelling and pain of ankles and knees, flaccidity and weakness. To treat dampness obstructing the spleen and stomach, and symptoms such as fullness in the abdomen, loss of appetite, fatigue, white greasy thick turbid tongue coating, etc., it is often used in combination with magnolia officinalis, tangerine peel, etc.; to treat cold-damp leucorrhea, it can be used together with Angelica dahurica. Such as damp-heat leucorrhea, it can also be combined with Anemarrhena, Sophora flavescens, and Mutouhui; for damp-heat betting, swollen and painful ankles, flaccidity and weakness, it can be used with Phellodendron Phellodendron, Achyranthes bidentata, Coix Seed, etc.; for damp-heat syndrome, it can be combined with plaster, Anemarrhena is equivalent to use.

Angelica dahurica pungent, warm. Return lung, stomach warp. Expelling wind and cold, clearing the orifice and relieving pain, detumescence and pus discharge, drying dampness and stopping belt. Dispelling rheumatism, promoting blood circulation and evacuating pus, promoting granulation and relieving pain. For headache, toothache, nasal sinusitis, intestinal wind and hemorrhoids, red and white vaginal discharge, carbuncle sores, skin itching. "Compendium": treatment of nasal sinusitis, epistaxis, toothache, brow bone pain, constipation of the large intestine, hemorrhage in urination, dizzy movement of women's blood wind, nausea and vomiting; solution of arsenic poisoning, snakebite, and sore caused by knives and arrows.

Ophiopogon japonicus nourishes yin and promotes body fluid, nourishes the lungs and clears the heart. For dry cough. Asthenic tuberculosis cough, thirsty fluid wound, upset and insomnia, internal heat and thirst, intestinal dryness and constipation; pharyngeal diphtheria. Control dryness of the lung and dry cough, spit blood, hemoptysis, impotence of the lung, lung abscess, asthenia and dysphoria, quench one's thirst, febrile disease fluid injury, dry throat and dry mouth, constipation. "Famous Physician's Bielu": Heal heavy eyesight, fullness of the heart, fatigue and heat, dry mouth and polydipsia, stop vomiting, heal flaccidity, strengthen yin and improve essence, eliminate grains and regulate the middle, protect the mind, calm the lung qi, An five viscera, making people fat and healthy.

Gansong promotes qi and relieves pain, relieves stagnation and awakens the spleen. Expelling dampness and detumescence for external use. For stagnation of qi stagnation due to cold in the middle Jiao, disharmony between the spleen and stomach, loss of appetite, and vomiting; external use for toothache. "Compendium of Materia Medica": "Pine pine, the aroma can relieve spleen depression, and less addition of spleen and stomach medicine can wake up the temper."

Shannai, also known as sand ginger and mountain spicy. The rhizome is used as medicine to warm the middle and remove dampness, promote qi and relieve pain. Indications for acute gastroenteritis, indigestion, cold stomach pain, toothache, rheumatic joint pain, bruises. Antibacterial effect: The root decoction has different degrees of inhibitory effects on 10 common pathogenic fungi such as Trichophyton schlenii and its Mongolian variant, Trichophyton symphysis, and Trichophyton violae in test tubes. Kaempferol has anti-inflammatory effect and vitamin P activity on animals. Its potency is similar to that of quercitrin, but worse than that of kaempferin.

Radix Asari dispels wind, disperses cold, promotes water circulation, and has one's ideas straightened out. Control wind-cold headache, nasal sinusitis, toothache, phlegm retention and cough, rheumatic arthralgia. The effect on the respiratory system: Asarum volatile oil has a very significant relaxation effect on the tracheal smooth muscle caused by histamine or acetylcholine spasm, and its antihistamine effect is stronger than that of acetylcholine. Methyl eugenol in Asarum volatile oil has obvious relaxing effect on isolated guinea pig trachea. In addition, the product has anti-inflammatory, immunosuppressive, local anesthesia and other effects.

Cornus officinalis nourishes the liver and kidneys, astringes, strengthens astringent, strengthens essence, shrinks urine, stops belt, stops collapse, stops sweating, and also produces body fluid and quenches thirst. Used for soreness of the waist and knees, dizziness and tinnitus, forgetful spermatorrhea, frequent urination, metrorrhagia, irregular menstruation, profuse sweating and prostration. Internal heat quenches thirst. Cornus officinalis, also known as yam meat, medicinal jujube, real jujube, jujube skin, meat jujube, etc., is a commonly used and precious Chinese medicinal material in my country with a long history of application. It has been favored by ancient medicine for its special effects such as strengthening and calming, strengthening yang but not helping fire, nourishing yin but not greasy, astringent but not staying evil. Zhang Zhongjing created "Jin Kui Shen Qi Wan" with Cornus officinalis as the king. According to chemical analysis, Cornus officinalis contains active ingredients such as cornel, tartaric acid, gallic acid, malic acid, resin, tannins and multivitamins with strong physiological activities, which have pharmacological effects such as enhancing immunity, anti-inflammatory, and antibacterial. A common medicine in Chinese medicine.

Anemarrhena is a heat-clearing gunpowder. It is mainly used to treat febrile diseases, high fever and polydipsia, cough and asthma, dry cough, constipation, bone steaming and hot flashes, fatigue and insomnia, diarrhea and turbidity. Clearing away heat and purging fire, promoting body fluid and moistening dryness. Clearing away heat and purging fire, promoting body fluid and moistening dryness. For exogenous febrile diseases, high fever and polydipsia, dry cough due to lung heat, hot flashes due to bone steaming, internal heat quenching thirst, intestinal dryness and constipation. Both gypsum and Anemarrhena can clear away heat and relieve fire, and can be used to treat febrile diseases such as excessive heat and cough due to lung heat. Gypsum is often used for fire headaches and toothaches; Anemarrhena is better than Qingrun for purging fire, dry cough with lung heat, internal heat bone steaming, and thirst.

Fructus Fructus Aurantii dispels qi, promotes phlegm, and eliminates stagnation. Control phlegm stagnation in the chest and diaphragm, chest fullness, hypotension, indigestion, gas, vomiting, heavy diarrhea, prolapse of the anus, and uterine prolapse. "Compendium of Materia Medica": Citrus aurantium, the main smell, is roughly the same as Citrus aurantii. But Fructus Aurantii is small in shape, full of qi, and strong in nature, so it is good for delivery; Fructus Aurantii is large in shape, its qi is scattered, and its nature is slow, so its action is a little later, so it can be divided into the chest, diaphragm, lung, stomach and enter the large intestine also. It governs wind-itch numbness, tonifies joints, relieves wind pain, covers the lungs to govern fur, stomach governs muscles, wind-cold and dampness enters the two meridians, resulting in skin itching, or pain, or numbness, this medicine has the function of releasing bitterness and relieving pain , and can also introduce various wind medicines into the two viscera, so it is needed for treating wind. Once the wind evil is dispersed, the joints will naturally benefit. It treats cough due to exhaustion, and those who are tired in the back and shoulders. Gai also refers to wind-cold stagnation in the upper burner, resulting in stagnation of lung qi and a tired cough.

The dandelion plant contains various healthy nutrients such as dandelion alcohol, dandelion, choline, organic acid, inulin, etc. It has diuretic, laxative, jaundice-reducing, choleretic and other effects. Dandelion also contains protein, fat, carbohydrates, trace elements and vitamins, etc., and has rich nutritional value. It can be eaten raw, fried, and made into soup. It is a plant that can be used as both medicine and food. Dandelion is a perennial herb belonging to the family Asteraceae. It is a plant with both medicine and food. According to the "Compendium of Materia Medica", it is flat in nature, sweet and slightly bitter, has the functions of clearing away heat and detoxifying, reducing swelling and promoting lactation, and is very effective in treating mastitis. Whether it is decocted orally or mashed and applied externally, it is all effective. In addition, dandelion has diuretic, laxative, anti-jaundice, choleretic and other effects, and is widely used in clinical practice. "Compendium of Materia Medica" has a saying: "Dandelion tender seedlings are edible, and raw food is especially good for treating infectious diseases." "Shen Nong's Materia Medica", "Tang Materia Medica", "Dictionary of Chinese Medicine" and other medical monographs of all dynasties have given high praise.

Embodiment 1: The production process of the honey-refined pill of the present invention is as follows: take notopterygium 1000g, citrus aurantium 1000g, kudzu root 1000g, herb 1000g, nepeta panicle 1000g, cicada slough 1000g, poria cocos 1000g, astragalus 1000g, angelica dahurica 1000g, radix radix 1000g, windproof 1000g, Scutellaria baicalensis 1000g, Gansong 1000g, Kaempfera 1000g, Asarum 1000g, Cornus officinalis 1000g. Soak the herbs in water for 30 minutes to 1 hour, heat and boil for 30 minutes, filter, and use the filtrate for later use; add water to the filter residue, heat for the second time, boil for 30 minutes, filter again, and use the filtrate for later use; add water to the filter residue, heat and boil for the third time for 30 minutes, Filtrate; combine the three filtrates, heat and condense to a paste, put it in an oven, control at 80°C, dry it, cool it into a powder form, mix it with an appropriate amount of honey, and knead it into thin strips; each 5g is a pill and sealed with wax.

Embodiment 2: when the present invention is accompanied by sore throat and tonsil enlargement, the capsule preparation process is as follows: take dandelion 1000g, honeysuckle 1000g, notopterygium 1000g, citrus aurantium 1000g, kudzu root 1000g, atractylodes 1000g, nepeta 1000g, Cicada slough 1000g, Poria 1000g, Astragalus 1000g, Angelica dahurica 1000g, Ophiopogon japonicus 1000g, Fangfeng 1000g, Scutellaria baicalensis 1000g, Gansong 1000g, Kaempferia 1000g, Asarum 1000g, Cornus officinalis 1000g. Add 5-10 times the amount of water to soak for 1-2 hours, extract twice; heat and extract for 1-2 hours, concentrate to extract, and become component 1; add 60-90% ethanol to the remaining medicinal residues for 24 hours, extract Twice, 1 hour each time, combine the extracts, filter, concentrate, filter at 100-160 mesh, centrifuge the supernatant at 6000-10000 rpm, and ultrafilter through an ultrafiltration column with a cut-off molecular weight of 5000-10000 , the ultrafiltrate is concentrated under reduced pressure to an extract with a relative density of 1.35 (80°C), heated and refluxed for 2 extractions, each time for 30-45 minutes, to extract the active ingredient, and the 2 extractions are combined and left to form an extract. as component 2. Concentrate and dry the above two extracts into a dry paste, mix and pulverize, add appropriate amount of starch, mix well, and fill capsules.

Embodiment 3: The preparation method when the present invention is made into oral liquid with fever and high fever is as follows: 500g forsythia, 500g Radix Radix, 500g Citrus aurantium, 1000g Pueraria radiata, 500g Nepeta panicle, 500g cicada slough, 500g Poria cocos, 500g Radix Astragali, 500g Angelica dahurica, wheat Winter 500g, Fangfeng 500g, Scutellaria baicalensis 500g, Gansong 500g, Kaempferen 500g, Cornus officinalis 500g, take all raw materials except asarum, notopterygium and atractylodes atractylodes, add water and decoct three times, each time add 5 to 10 times the amount of water, soak, decoct Boil and filter; discard the dregs, combine the filtrate, evaporate and concentrate under reduced pressure to a concentrated solution with a relative density of 1.10-1.15 at 60-70°C, let it stand for 24 hours, and take the supernatant; then add Asarum 500g, Extract 500g of notopterygium and 500g of atractylodes atractylodes by steam distillation to obtain crystals; put Asarum, notopterygium and atractylodes atractylodes crystals into the concentrated solution, add dextrin to sterilize and make medicine. The concentrated solution is sterilized with CO60, the irradiation dose is 8k, dextrin is added, and then vacuum-frozen and sealed.

Embodiment 4: The present invention is used as a tablet production process when the symptoms of poor appetite and inability to digest food are as follows: 500g of asarum, 500g of notopterygium and 500g of atractylodes rhizome are put into a distillation pot and steam distilled into essential oil; The remaining raw materials are 500g Forsythia, 500g Radix Radix, 500g Citrus aurantium, 1000g Gegen, 500g Schizonepetae, 500g Cicada slough, 500g Poria, 500g Astragalus, 500g Angelica, 500g Radix Radix, 500g Fangfeng, 500g Scutellaria, 500g Gansong, and 500g Kaempferen , Cornus officinalis 500g, add 5-10 times the amount of water to soak for 1-2 hours, heat and extract twice, each time for 1-2 hours, remove the supernatant, combine the extracts, filter with 100-120 mesh, and then pass through the cut-off molecular weight It is ultrafiltered with an ultrafiltration column of 5000-10000, and the ultrafiltrate is vacuum-concentrated to an extract with a relative density of 1.38 at 80°C, heated and concentrated for 30 to 45 minutes, concentrated to an extract, left to stand for later use, and becomes component 1 Put the medicinal residues extracted by water into 10 times the amount of ethanol, heat and reflux for extraction once, the extraction time is 1 to 2 hours, filter with 100-120 mesh, and then pass through an ultrafiltration column with a cut-off molecular weight of 5000-10000 Filtration, the ultrafiltrate was concentrated under reduced pressure to the extract with a relative density of 1.38 at 80°C, concentrated by heating for 30 to 45 minutes, concentrated to an extract, left to stand for later use, and became component 2. Concentrate and dry the extracts of the above two components into a dry paste, mix and pulverize, add appropriate amount of starch, mix well and press into tablets.

Embodiment 5: The preparation method of the tablet when the present invention sees excessive phlegm and cough is as follows: get 500g of Bubu, 500g of Anemarrhena, 500g of Citrus aurantium, 1000g of Pueraria lobata, 500g of Schizonepetae, 500g of cicada slough, 500g of Poria cocos, 500g of Radix Astragali , 500g Angelica dahurica, 500g Ophiopogon japonicus, 500g Fangfeng, 500g Scutellaria baicalensis, 500g Gansong, 500g Kaempferum, 500g Cornus officinalis, 500g Asarum, 500g Notopterygium and 500g Atractylodes atractylodes, weigh the raw materials and crush them into granules, add water, heat to 30℃, warm Soak for 1 hour, then distill for 1 hour, distill the dregs with distilled water for 2 times, 1 hour each time; mix the three distillates, add 10% sodium chloride, refrigerate, separate the supernatant, add 4 times the amount of β- Cyclodextrin, appropriate amount of water, add cyclodextrin inclusion compound, starch, mix evenly, compress into tablets, and then coat with film coating solution to obtain tablets.

Pharmacological toxicity test

1. Acute toxicity test

Application of mice to carry out acute toxicity test shows: mice orally gavage traditional Chinese medicine preparation capsules of the present invention, under 346.2g crude drug/kg dose, after the administration, the mice appear to have a slight decrease in activity, and return to normal in about 1 hour. Continuously observed for 7 days, no animal died, and its general condition, diet, water intake, urination and body weight gain were all normal. The experimental results showed that the maximum dosage of the traditional Chinese medicine preparation capsule of the present invention was 346.2g in mice orally. Crude drug/kg/d (LD50>346.2g crude drug/kg). The daily clinical dosage of the traditional Chinese medicine preparation of the present invention is 0.1 g crude drug/kg/d; in terms of body weight, the tolerated dose of the traditional Chinese medicine preparation of the present invention in mice is 3462 times that of clinical patients. It is suggested that the drug has low acute toxicity and is safe for clinical use.

2. Long-term toxicity test

Select SD rats for use, give different concentrations (18.0, 6.0, 2.0g crude drug/kg) of the traditional Chinese medicine preparation pills of the present invention, gavage once a day, for 90 consecutive days, and kill 1/2 animals alive in each group 24 hours after the last administration (half male and half male), and the remaining 1/2 animals were kept under observation for 2 weeks before being killed alive. During the test, the appearance, general behavior, food intake and body weight changes of the animals were observed, and hematology (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemistry ( AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology and other indicators inspection. Result of the test shows: the Chinese medicine preparation of the present invention is in high, middle and low dose group animal's general state is good, and appearance sign, behavioral activity, food intake and body weight increase all have no abnormal change; The biochemical and urine biochemical examinations were within the normal range, and there was no significant difference between the groups; no obvious abnormalities were found in the histopathological examination of major organs in each group. The above indicators did not change after 2 weeks of drug withdrawal. The test dosage is respectively 180, 60, and 20 times of the clinical dosage, and according to the test results, the Chinese medicine preparation of the present invention is administered continuously for 90 days at high, medium and low dosages (18.0, 6.0, 2.0g crude drug/kg). It has no obvious effect on rats, no clear target organs of toxicity and sensitive indicators, and no delayed toxic reaction is observed in the recovery period, suggesting that the dose safety of the clinical application of the traditional Chinese medicine preparation of the present invention is relatively high.

3, select SD rats for use, give the Chinese medicine preparation of the present invention of different concentrations (18.0, 6.0, 2.0g crude drug/kg), gavage once a day, continuous 90 days, each group kills 1/2 alive 24 hours after the last administration Animals (half male and half female), and the remaining 1/2 animals continued to be observed for 2 weeks before being killed alive. During the test, the appearance, general behavior, food intake and body weight changes of the animals were observed, and hematology (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemistry ( AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology and other indicators inspection. Result of the test shows: the Chinese medicine preparation of the present invention is in high, middle and low dose group animal's general state is good, and appearance sign, behavioral activity, food intake and body weight increase all have no abnormal change; The biochemical and urine biochemical examinations were within the normal range, and there was no significant difference between the groups; no obvious abnormalities were found in the histopathological examination of major organs in each group. The above indicators did not change after 2 weeks of drug withdrawal. The test dosage is respectively 180, 60, and 20 times of the clinical dosage, and according to the test results, the Chinese medicine preparation of the present invention is administered continuously for 90 days at high, medium and low dosages (18.0, 6.0, 2.0g crude drug/kg). It has no obvious effect on rats, no clear target organs of toxicity and sensitive indicators, and no delayed toxic reaction is observed in the recovery period, suggesting that the dose safety of the clinical application of the traditional Chinese medicine preparation of the present invention is relatively high.

Pharmacological and drug effect experiment of the present invention:

Experimental research on antipyretic effect of the present invention

(1) Experimental materials:

1. Animals: Healthy big-eared white rabbits, weighing (2.4±0.3) kg, both male and female. Provided by Shandong Agricultural University.

2. Drugs: Drug A: Chinese medicine preparations prepared according to the method of the present invention (groups A1 to A5 are honey-refined pills, capsules, oral liquids, tablets, tablets prepared in Example 1 to Example 5 of the present invention respectively Chinese herbal preparations).

Drug B: Prepared according to the method described in "Fever Oral Liquid".

Drug C: Prepared according to the process described in "Gui Ma Chai Antipyretic Granules and Production Process".

3. Instrument: computer digital thermometer.

(2) Experiment method: take 24 healthy big-eared white rabbits, 3 days before the experiment, at room temperature 22-25 ℃, humidity 55%-65%, in a ventilated environment, measure the anal temperature of the animals once every 1 hour for a total of 4 The second time, the animals are adapted, and the animals whose body temperature fluctuates within 0.4°C are selected for use. During the experiment, the animals were randomly divided into 4 groups according to body weight, which were normal saline group, group A, group B and group C. The anal temperature of the rabbit was measured once every 30 minutes with a computer digital thermometer, and the temperature was measured 3 times in total, and the average value was calculated as the basal body temperature of the animal. Rabbits were injected with inactivated Escherichia coli into the ear edge vein at 1ml/kg to cause fever, and were given twice by intragastric administration 30 minutes before and 30 minutes after the fever. The rectal temperature of the rabbits was measured 5 times at 30, 60, 120, 240 and 360 minutes after heating, and the difference between the rectal temperature and the basal body temperature of the rabbits in each group after treatment was calculated for statistical processing.

(3) Experimental results: see Table 1 for details.

Table 1 Changes in body temperature of animals in each group at different time periods after treatment

(4) Conclusion: As can be seen from Table 1, the results show that group A has obvious antipyretic effect on rabbits with fever caused by Escherichia coli, and its antipyretic effect is better than that of group B and group C, and its antipyretic effect is better than that of group B Groups and C are persistent.

The clinical manifestations of upper flu in children are: cold at the beginning, or it has lasted for several days, slight aversion to cold, no sweat, or sweating, burning head and body, cold hands and feet, drowsiness or irritability, red lips, mouth Gansiyin, thin white or yellowish tongue coating, floating and tense pulse, red and purple veins. In children with cold and high fever, there are few cases of pure wind-cold or wind-heat, but most of them are external cold and internal heat or "cold pack heat". If only pungent and warm are used to dissipate, the external cold will go away, but the internal heat will re-emerge; if only pungent and cool are used to relieve, the external cold will love, and the internal heat will have no way out. Practice has proved that combining pungent temperature with pungent cold can open the Xuanfu and clear the accumulated heat; supplemented by pivoting and lifting, the heat can be drawn out, supplemented with sour and sweet to transform yin, harmonize the camp and expel the heat, and the place that is not affected by evil is safe first. , in order to "complete its merits in one shot".

1 clinical data

According to the diagnostic criteria of recurrent respiratory tract infection, 160 children with recurrent respiratory tract infection (RRTI) were randomly divided into two groups according to the order of visit time. The treatment group consisted of 80 cases, 38 males and 42 females; 50 cases aged 1-2 years old, 23 cases aged 2.1-5 years old, and 7 cases aged 5.1-7 years old. The control group consisted of 80 cases, including 41 males and 39 females; 48 cases aged 1-2 years old, and 21 cases aged 2.1-5 years old. 11 cases aged 5.1-7 years old. There was no significant difference between the two groups in terms of age and gender.

2 treatment methods

The control group was routinely given anti-infection and symptomatic treatment during the onset. Thymosin 5mg:, add 10% GS50ml intravenous infusion, once a day. Medication for upper respiratory tract infection for 3-7 days, bronchitis and pneumonia for 2 weeks. The routine treatment of the treatment group during the onset period was the same as that of the control group, without thymosin. After the condition is stable, give traditional Chinese medicine susceptible prescription: Notopterygium, Citrus aurantium, Pueraria lobata, Atractylodes atractylodes, Schizonepetae, Cicada slough, Poria cocos, Astragalus, Angelica dahurica, Ophiopogon japonicus, Fangfeng, Scutellaria baicalensis, Gansong, Kaempferia, Asarum, Cornus officinalis. For children with sore throat and enlarged tonsils, add dandelion and honeysuckle. Forsythia and Radix Radix are added to children with high fever. Add hawthorn and gallinaceous gold when the child is accompanied by anorexia and indigestion. When the child is accompanied by phlegm and cough, add Baibu, Zhimu. One dose per day, decocted in water, for a total of 3 weeks. If you suffer from respiratory tract infection while taking the medicine, continue anti-infection and symptomatic treatment.

3 Efficacy criteria and treatment results

Efficacy standard markedly effective: no respiratory tract infection or only one respiratory tract infection occurred 6 months after drug withdrawal; effective: the number of respiratory tract infections decreased or did not decrease, but the symptoms of each infection were lighter than before and the course of disease was shortened; invalid: the number of respiratory tract infections was no more than before treatment Variety.

The curative effect comparison of the two groups is shown in Table 1.

Compared with the control group, p<0.01

normal information

The 58 cases of children observed clinically by the present invention all meet the diagnostic criteria for recurrent respiratory tract infection in children formulated by the Chengdu Conference on National Pediatric Respiratory Diseases in 1987. Among them, there were 35 males and 23 females; the age ranged from 2 to 12 years; the course of disease was more than 1 year. All the selected children were excluded from primary immunodeficiency disease and children with immunosuppressive agents due to other diseases (such as nephritis).

treatment method

Traditional Chinese medicine prescriptions are used: notopterygium, citrus aurantium, kudzu root, atractylodes atractylodes, nepeta ear, cicada slough, poria cocos, astragalus, angelica, Radix Ophiopogon japonicus, windproof, scutellaria baicalensis, sweet pine, kaempferia, asarum, dogwood.

For children with sore throat and enlarged tonsils, add dandelion and honeysuckle.

Forsythia and Radix Radix are added to children with high fever.

Add hawthorn and gallinaceous gold when the child is accompanied by anorexia and indigestion.

When the child is accompanied by phlegm and cough, add Baibu, Zhimu. Grind into fine powder and take it twice a day. ≤ 7 years old 2g each time, > 8 years old 3g each time, 1 month as a course of treatment. Before and after treatment, venous blood IgA, IgG, IgM and T lymphocyte subsets (CD3+, CD4+, and CD8+) were checked. During the period of medication, re-examination was performed once every 2 weeks, and once a day after drug withdrawal, until 3 months.

treatment result

Judgment criteria for curative effect: markedly effective: no respiratory tract infection occurred within half a year of medication; effective: the number of episodes of respiratory tract infection decreased by 1-2 compared with the same period last year within half a year of medication, and the course of the disease was shortened; ineffective: the number of episodes and the condition were not significantly improved. Results Among the 58 children, 36 cases were markedly effective, 16 cases were effective, and 6 cases were ineffective. The total effective rate was 89.7%. The changes of immune indexes before and after treatment are shown in Table 1.

Table 1 Comparison of immune index changes before and after treatment

immune index Before treatment After treatment IgG (g/L) 6.12±0.14 7.89±0.19 IgA (g/L) 5.16±0.46 9.87±0.26 IgM (g/L) 0.97±0.14 1.23±0.27 CD3+(%) 40.1±1.7 56.9±1.6 CD4+(%) 24.4±1.6 33.7±1.8 CD8+(%) 20.4±1.9 24.6±1.2

After treatment, the immune indexes IgA, IgG, IgM, CD3+, CD4+, and CD8+ of the children were all higher than those before treatment, and there was a significant difference compared with before treatment (P<0.05).

discuss

The pathogenesis of recurrent respiratory tract infection in children is complex and related to many factors. Many studies believe that it is closely related to the low function of humoral and cellular immunity. Applying this traditional Chinese medicine formula can improve the body resistance and immune function of the children. In the prescription, Astragalus nourishes qi to solidify the surface and strengthen the body, and Poria cocos invigorates the spleen and nourishes qi. The combination of the two can make the qi vigorous and firm on the surface, sweating does not leak out, and evils are not easy to invade inward; And Fructus Aurantii can invigorate the spleen and kidney. According to the above observations, this prescription can effectively improve various immune indexes, so it has a significant effect on recurrent respiratory tract infection in children.

Embodiment 1: Qin, man, 4 years old, first visit on July 5, 2010. The mother said that she returned home from a trip in April, opened the car windows on the way, slept soundly and caught the cold, and developed a high fever that night with a body temperature of 39.5°C. Antibiotics and antipyretic western medicine were used, and the high fever subsided (never lower than 38°C), but rebounded immediately , Repeated respiratory tract infection for 2 months, western medicine used a lot, not cured the root cause, asked to be treated with traditional Chinese medicine. Immediate diagnosis: body temperature 38°C, mental exhaustion, no sweat in the whole body, scorching heat in the forehead and body, cold hands and feet, slight sore throat, dry mouth and desire to drink, poor appetite, dry stool, less yellow urine, reddish tongue, thin yellow fur , pulse floating number. Yuben prescription: notopterygium 7g, citrus aurantium 10g, kudzu root 10g, atractylodes 5g, nepeta panicle 7g, cicada slough 9g, poria cocos 10g, astragalus 10g, angelica dahurica 6g, radix radix 10g, windproof 7g, scutellaria baicalensis 8g, Gansong 9g, kaempferia 7g , Asarum 8g, Cornus officinalis 6g, Forsythia 8g, Radix Radix 9g. Stop using all western medicines, take a course of treatment for 7 days, and make pills. Started to sweat slightly, head and body heat decreased, hands and feet became warmer, bowel movements were unobstructed, spirits were slightly refreshed, and body temperature dropped to 37.5°C; continued for a course of treatment, body temperature was normal, spirit improved, sore throat was relieved, lips were moisturized, and Know hunger and ask for food. Drug withdrawal was observed for one week, and recovery was as before. Follow up a case by regular visits to half a year without recurrence.

Example 2: Pan, female, 5 years old, her parents said that she contracted a cold in the kindergarten, and the child had a persistent cough. After more than 14 days, she went to see a doctor, and she still coughed intermittently, and had a cold; half a month ago, she had a cough, runny nose, and shortness of breath due to a cold. , Fever, once went to another hospital for bronchial tuberculosis, taking western medicine to relieve fever and asthma slightly reduced, but coughing continued, sputum was not easy to cough up, severe cough at night, paroxysmal, accompanied by vomiting saliva or food. Naco, dry stool, frequent urination. Symptoms include normal spirit, runny nose, red and swollen throat, reddish tongue, yellowish greasy fur, and purple fingerprints. Symptoms belong to cold and cough, with damp heat inside. Prescription: notopterygium 7g, citrus aurantii 6g, kudzu root 8g, atractylodes atractylodes 6g, Nepeta panicle 8g, cicada slough 8g, poria cocos 10g, astragalus 10g, angelica dahurica 6g, radix radix 10g, fangfeng 7g, scutellaria baicalensis 8g, Gansong 9g, Kaempfera 7g, Asarum 8g, Cornus officinalis 6g, Baibu 5g, Anemarrhena 6g. Stop using all western medicines, take the present invention as a granule, take 1 pack each time, three times a day, take a course of treatment for 7 days, start to sweat slightly, head and body heat decreases, hands and feet turn warm, bowel movement is unimpeded, and the spirit is slightly refreshed After 2 weeks, the body temperature was normal, the spirit improved, the sore throat was relieved, the lips were moisturized, and the hunger was relieved. Drug withdrawal was observed for one week, and recovery was as before. Follow up a case by regular visits to half a year without recurrence.

Example 3: Lu X, 3 years old, male, the parents reported that they went to the kindergarten to catch a cold for a week, and they used antibiotics and antipyretic western medicines. When the fever was high, they coughed repeatedly for 2 months. They used a lot of cough syrup and western medicines but did not recover. Chinese medicine treatment. Immediate diagnosis: body temperature 38°C, mental exhaustion, no sweating throughout the body, scorching heat on the forehead and body, slight pain in the throat, difficulty swallowing, enlarged tonsils, hoarse speech, and tearing sounds. Recipe: notopterygium 6g, citrus aurantium 6g, kudzu root 8g, atractylodes 5g, nepeta panicle 8g, cicada slough 8g, poria cocos 10g, astragalus 10g, angelica dahurica 6g, radix radix 8g, windproof 7g, scutellaria baicalensis 8g, pine 5g, kaempferia 7g, Asarum 8g, Cornus officinalis 6g, Dandelion 9g, Honeysuckle 10g, stop using all western medicines, make the present invention into granules and take, take 1 pack each time, three times a day, take a course of treatment for 7 days, start to reduce head and body heat, turn hands and feet Warm, the second bowel movement is unobstructed, the spirit is slightly refreshed, the sore throat is relieved, the lips are moistened, and the voice starts to be normal; continue to use a course of treatment, the body temperature is normal, the spirit improves, the sore throat is completely healed, and the tonsils no longer hurt. Drug withdrawal was observed for one week, and recovery was as before. Follow up a case by regular visits to half a year without recurrence.

Embodiment 4: Gu, female, 5 years old, her parents said she caught a cold while taking a bath, and she had a cold and fever for more than a week. Sometimes self-report abdominal pain, dry stool. Seeing a doctor after more than 10 days, still coughing intermittently. Symptoms include normal spirit, runny nose, reddish tongue, yellowish greasy fur, and purple fingerprints. Recipe: Notopterygium 5g, Citrus aurantii 6g, Pueraria lobata 8g, Atractylodes 6g, Schizonepeta 8g, Cicada slough 8g, Poria cocos 10g, Astragalus 6g, Angelica 6g, Ophiopogon japonicus 10g, Fangfeng 7g, Scutellaria baicalensis 8g, Gansong 9g, Kaempferia 7g, Asarum 8g, Cornus officinalis 6g, Baibu 5g, Anemarrhena 6g, Hawthorn 9g, Gallinarum 8g. Made into tablets. Stop using all western medicines, take 2 tablets each time, three times a day, take a course of treatment for 7 days, the body temperature is normal, the spirit is slightly refreshed, the cough is relieved, the lips are moistened, the hunger is demanded, and the stool is unimpeded. Continue to take a course of treatment, fully recover, and diet is normal. Follow up a case by regular visits to half a year without recurrence.

Embodiment 5: Fang X, 4 years old, parents readme from more than two years old and began to cough repeatedly, catch a cold, pneumonia, bronchitis etc. Every time I have to use anti-inflammatory drugs and infusion to cure it, but I have repeated coughing and sickness almost every half a month. The self-contained medical records show: Cough on September 15, 2011, Cough on October 13, 2011, Cough on October 13, 2011 October 28, bronchitis, December 5, 2011 bronchitis, December 24, 2011 cold, January 10, 2012 viral cold, February 9, 2012 pneumonia secondary inflammation of the tonsils, March 2012 Cold and cough on the 15th, cold and cough on April 6, 2012. The child has a poor physique and is yellow and thin. Recipe: notopterygium 5g, citrus aurantium 6g, kudzu root 8g, atractylodes 6g, nepeta panicle 8g, cicada slough 8g, poria cocos 10g, astragalus 6g, angelica 6g, radix radix 8g, windproof 7g, scutellaria baicalensis 8g, Gansong 9g, kaempferum 7g, Asarum 6g, Cornus officinalis 7g, made into granules, three times a day, one pack each time. After a week of conditioning, I began to sweat slightly, the heat of the head and body decreased, the temperature of the hands and feet turned warm, the stool was unobstructed, the spirit was slightly refreshed, and the body temperature was normal. At the beginning, 6g of Baibu and 7g of Anemarrhena were added to the normal prescription. Even served for 2 weeks. The cough began to gradually improve, and continued to use for 2 weeks, and the tracheal inflammation began to disappear. Continue to use the basic prescription of the present invention, start to add hawthorn 9g, gallinacea 8g, and the child's diet begins to be normal, and the lips are moisturized and the mouth is soft, and the hunger is demanded for food, and the two stools are unimpeded. Continue to take one month, recover completely, and diet is normal. The complexion is rosy, and I am no longer prone to colds and coughs. I asked the parents to exercise properly to enhance their physical fitness. Now the children are beginning to gain weight and their physical fitness has improved.

Claims (5)

1. A traditional Chinese medicine preparation for treating infantile respiratory tract infection with anorexia, characterized in that the weight-number ratio of various raw materials in the preparation is: 10-15 parts of notopterygium, 10-15 parts of Fructus aurantii, 10 parts of kudzu root ～15 parts, Atractylodes 10～15 parts, Nepeta 10～15 parts, cicada slough 10～15 parts, Poria cocos 10～15 parts, Astragalus 10～15 parts, Angelica dahurica 10～15 parts, Ophiopogon japonicus 10～15 parts, Fangfeng 10-15 parts, 10-15 parts of Scutellaria baicalensis, 10-15 parts of Gansong, 10-15 parts of Kaempferen, 10-15 parts of Asarum, 10-15 parts of Cornus officinalis, 10-15 parts of hawthorn, 10-15 parts of Gallus gallis . 2. The traditional Chinese medicine preparation for treating infantile respiratory tract infection with poor appetite according to claim 1, characterized in that the weight-to-number ratios of various raw materials in the preparation are: notopterygium 12-15 parts, citrus aurantii 10-15 parts 10-15 parts of kudzu root, 12-15 parts of atractylodes rhizome, 10-15 parts of Nepeta panicle, 10-15 parts of cicada slough, 10-15 parts of Poria cocos, 10-15 parts of astragalus, 12-15 parts of Angelica dahurica, 10-15 parts of Ophiopogon japonicus. 15 parts, Fangfeng 12-15 parts, Scutellaria baicalensis 12-15 parts, Gansong 10-15 parts, Kaempfera 12-15 parts, Asarum 10-15 parts, Cornus officinalis 10-15 parts, Hawthorn 10-15 parts, Gallus gallis 10 to 15 servings. 3. The traditional Chinese medicine preparation for treating infantile respiratory tract infection with poor appetite according to claim 1, characterized in that the weight-to-number ratio of various raw materials in the preparation is: notopterygium 10-15 parts, citrus aurantii 10-15 parts 10-12 parts of kudzu root, 10-12 parts of atractylodes rhizome, 10-15 parts of Nepeta panicle, 10-15 parts of cicada slough, 10-15 parts of Poria cocos, 10-15 parts of astragalus, 10-15 parts of Angelica dahurica, 10-15 parts of Radix Ophiopogon japonicus. 15 parts, Fangfeng 10-12 parts, Scutellaria baicalensis 10-15 parts, Gansong 10-15 parts, Kaempfera 10-15 parts, Asarum 10-15 parts, Cornus officinalis 10-15 parts, Hawthorn 10-12 parts, Gallus gallis 10-12 servings. 4. The traditional Chinese medicine preparation for treating infantile respiratory tract infection with poor appetite according to claim 1, characterized in that, the weight-to-number ratio of various raw materials in the preparation is: notopterygium 10-12 parts, citrus aurantii 10-15 parts 12-15 parts of kudzu root, 10-12 parts of atractylodes rhizome, 10-15 parts of nepeta, 12-15 parts of cicada slough, 10-15 parts of Poria cocos, 10-15 parts of astragalus, 12-15 parts of Angelica dahurica, 10-15 parts of Ophiopogon japonicus. 15 parts, Fangfeng 10-12 parts, Scutellaria baicalensis 10-15 parts, Gansong 10-12 parts, Kaempfera 10-15 parts, Asarum 10-15 parts, Cornus officinalis 10-15 parts, Hawthorn 10-15 parts, Gallus gallis 10 to 15 servings. 5. The traditional Chinese medicine preparation for treating respiratory tract infection in children with poor appetite according to claim 1, characterized in that, the weight-to-number ratio of various raw materials in the preparation is: 10-15 parts of notopterygium, 10-12 parts of Citrus aurantii. 10-15 parts of kudzu root, 10-15 parts of atractylodes rhizome, 10-15 parts of Nepeta panicle, 10-15 parts of cicada slough, 12-15 parts of Poria cocos, 12-15 parts of astragalus, 10-12 parts of Angelica dahurica, 10-10 parts of Ophiopogon japonicus. 15 parts, Fangfeng 10-15 parts, Scutellaria baicalensis 10-15 parts, Gansong 10-12 parts, Kaempfera 10-15 parts, Asarum 10-15 parts, Cornus officinalis 10-12 parts, Hawthorn 10-15 parts, Gallus gallis 10 to 15 servings.