CN105311581A

CN105311581A - Traditional Chinese medicine composition for preventing and treating hyperplasia of mammary glands and preparation method thereof

Info

Publication number: CN105311581A
Application number: CN201510874058.3A
Authority: CN
Inventors: 王翠平; 刘久美; 慕强
Original assignee: Qingdao Central Hospital
Current assignee: Qingdao Central Hospital
Priority date: 2015-12-02
Filing date: 2015-12-02
Publication date: 2016-02-10

Abstract

The invention relates to the field of traditional Chinese medicines and in particular relates to a traditional Chinese medicine composition for preventing and treating hyperplasia of mammary glands. The traditional Chinese medicine composition is composed of lychee seed, tangerine seed, mulberry twig, pangolin scales, common selfheal fruit-spike, zedoray rhizome, nutgrass galingale rhizome, green tangerine peel, bulb of thunberg fritillary, Indian buead, radix bupleuri, cowherb seed, Chinese angelica, dragon's blood, frankincense, white paeony root, pinellia tuber, radix codonopsis, suberect spatholobus stem, glossy privet fruit, barbary wolfberry fruit, motherwort herb, oriental waterplantain rhizome, and the like. Compared with the prior art, the traditional Chinese medicine composition has the advantages of good curative effects, low cost, small limitation, no adverse reactions, and the like. The traditional Chinese medicine composition has the beneficial effects that the traditional Chinese medicine composition has the functions of relieving the depressed liver, reducing phlegm and resolving masses and promoting blood circulation to dispel blood stasis; through mutual compatibility, all the ingredients act on various pathological levels of hyperplasia of mammary glands; and the traditional Chinese medicine composition has the functions of removing toxicity, resolving masses and eliminating diseases and inducing diuresis for treating stranguria and can achieve the effect of improving various pathological changes of hyperplasia of mammary glands as a whole to achieve the aim of treating hyperplasia of mammary glands.

Description

Chinese medicine composition of a kind of prevention and therapy cyclomastopathy and preparation method thereof

Technical field

The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to Chinese medicine composition of a kind of prevention and therapy cyclomastopathy and preparation method thereof.

Background technology

Cyclomastopathy is that cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of Progressive symmetric erythrokeratodermia connective tissue, and its pathogenic factor is mainly due to endocrine hormone imbalance.Cyclomastopathy is the modal cystic hyperplasia of breast of women, and its sickness rate accounts for the first place of mastopathy.This sick sickness rate was in the trend risen year by year in the last few years, and the age also more and more becomes younger.About there is the women of 70% ~ 80% to have cyclomastopathy in various degree according to investigations, be more common in the women of 25 ~ 45 years old.

Cyclomastopathy is the common disease of a kind of gynecological.Be apt to occur in the middle-aged women about 25-39 year, because be women's sexual function the most vigorous period during this period of time.Show as the different parts single-shot of breast or multiple grow some lumps, quality is soft, and obscure boundary is movable, often with pain in various degree.Especially after premenstrual in the moon, tired or the anxious state of mind such as angry (traditional Chinese medical science claims the stagnation of QI) time, lump increases, and pain increases the weight of, and after menstruation, lump obviously reduces, pain relief.Pain is generally distending pain, little tingle.Should remind, cyclomastopathy changes as the possibility of mazalgia, if so suffer from mammary gland have hypertrophy time comparatively elder, should remove examination in hospital, so that timely Diagnosis and Treat.

The medicine for the treatment of cyclomastopathy in the market mainly contains the Chinese patent medicines such as breast peaceful granule, GUIZHI FULING JIAONANG, PINGXIAO JIA0NANG, these Chinese patent medicine specific aims are not strong, even mostly be the medicine for the treatment of gynecological various diseases treatment tumor, doublely control cyclomastopathy, or only for a certain symptom or a certain pathology link of cyclomastopathy, and expensive.

Summary of the invention

In order to overcome deficiency of the prior art, the invention provides a kind of Chinese medicine composition of prevention and therapy cyclomastopathy, to cyclomastopathy, there is significant curative effect.

In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of Chinese medicine composition of prevention and therapy cyclomastopathy, is made up of following component:

Semen Litchi, Semen Citri Reticulatae, Ramulus Mori, Squama Manis, Spica Prunellae, Rhizoma Curcumae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Bulbus Fritillariae Thunbergii, Poria, Radix Bupleuri, Semen Vaccariae, Radix Angelicae Sinensis, Sanguis Draxonis, Olibanum, the Radix Paeoniae Alba, the Rhizoma Pinelliae, Radix Codonopsis, Caulis Spatholobi, Fructus Ligustri Lucidi, Fructus Lycii, Herba Leonuri, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Semen Cassiae, Fructus Trichosanthis, Herba Taraxaci, Flos Lonicerae, Cortex Acanthopancis, Radix Notoginseng, Fructus Forsythiae, Serissa foetida.

Further, the present invention is made up of each component of following parts by weight:

Semen Litchi 1-30 part, Semen Citri Reticulatae 1-30 part, Ramulus Mori 1-30 part, Squama Manis 0.05-30 part, Spica Prunellae 1-30 part, Rhizoma Curcumae 1-30 part, Rhizoma Cyperi 1-30 part, Pericarpium Citri Reticulatae Viride 1-30 part, Bulbus Fritillariae Thunbergii 1-30 part, Poria 1-30 part, Radix Bupleuri 1-30 part, Semen Vaccariae 1-30 part, Radix Angelicae Sinensis 0.05-30 part, Sanguis Draxonis 1-30 part, Olibanum 1-30 part, Radix Paeoniae Alba 1-30 part, Rhizoma Pinelliae 1-30 part, Radix Codonopsis 0.05-30 part, Caulis Spatholobi 1-30 part, Fructus Ligustri Lucidi 1-30 part, Fructus Lycii 1-30 part, Herba Leonuri 1-30 part, Rhizoma Alismatis 1-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Radix Glycyrrhizae 1-30 part, Semen Cassiae 1-30 part, Fructus Trichosanthis 1-30 part, Herba Taraxaci 1-30 part, Flos Lonicerae 1-30 part, Cortex Acanthopancis 1-30 part, Radix Notoginseng 1-30 part, Fructus Forsythiae 1-30 part, Serissa foetida 1-30 part.

Semen Litchi 1-15 part, Semen Citri Reticulatae 1-15 part, Ramulus Mori 1-15 part, Squama Manis 0.05-15 part, Spica Prunellae 1-15 part, Rhizoma Curcumae 1-15 part, Rhizoma Cyperi 1-15 part, Pericarpium Citri Reticulatae Viride 1-15 part, Bulbus Fritillariae Thunbergii 1-15 part, Poria 1-15 part, Radix Bupleuri 1-15 part, Semen Vaccariae 1-15 part, Radix Angelicae Sinensis 0.05-15 part, Sanguis Draxonis 1-15 part, Olibanum 1-15 part, Radix Paeoniae Alba 1-15 part, Rhizoma Pinelliae 1-15 part, Radix Codonopsis 0.05-15 part, Caulis Spatholobi 1-15 part, Fructus Ligustri Lucidi 1-15 part, Fructus Lycii 1-15 part, Herba Leonuri 1-15 part, Rhizoma Alismatis 1-15 part, Rhizoma Atractylodis Macrocephalae 1-15 part, Radix Glycyrrhizae 1-15 part, Semen Cassiae 1-15 part, Fructus Trichosanthis 1-15 part, Herba Taraxaci 1-15 part, Flos Lonicerae 1-15 part, Cortex Acanthopancis 1-15 part, Radix Notoginseng 1-15 part, Fructus Forsythiae 1-15 part, Serissa foetida 1-15 part.

Further, the present invention also comprises each component composition of following parts by weight: Rhizoma Paridis 1-15 part, Fructus Citri Sarcodactylis 1-15 part, Ganoderma 1-15 part, Cordyceps 1-15 part.

Further, the dosage form of Chinese medicine preparation of the present invention is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup.

In order to solve the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine composition of prevention and therapy cyclomastopathy, and prepared by described capsule comprises the following steps:

A. described crude drug is put into pulverizer grinding and sieving,

B. the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times;

C. the medicinal residues after above-mentioned ethanol extraction are got again, the heating and refluxing extraction that adds water 2 times;

D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.

Further, in described step a, put into by described crude drug after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 50%, collects by the raw material fine powder of 100 mesh sieves for subsequent use.

Further, in described step b, the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 3 hour, 2 extracting solution are merged and leaves standstill; In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 3 hour, 2 extracting solution are merged and leaves standstill.

Further, in described steps d, above-mentioned two kinds of ethanol extracts are merged, when concentrating under reduced pressure relative density is 70 DEG C 1.08 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m2, hothouse hot stream temperature is 60 DEG C, obtains raw material medicated powder; The raw material fine powder obtained after sieving and ethanol are refined medicated powder to mix and incapsulate.

Further, the dosage form of described Chinese medicine preparation is oral solutions, and its preparation process comprises:

A, get crude drug and put into water and soak, heat is extracted 2 times, and becoming extractum shape, is component 1;

B, medicinal residues ethanol extraction 1 time, thickening filtration is extractum shape, is component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, and then vacuum freezing seals and get final product.

The present invention has the advantages such as good effect, cost is low, limitation is little, have no adverse reaction relative to prior art.The present invention has dispersing the stagnated live-QI to relieve the stagnation of QI, dissipating phlegm and resolving masses, the mutual compatibility of blood circulation promoting and blood stasis dispelling, each component acts on each pathology aspect of cyclomastopathy, have detoxicating and resolving stagnation of pathogens Xiao Disorder, the effects such as dampness removing is treating stranguria, the various pathological changes that overall can improve cyclomastopathy reach treatment cyclomastopathy object.Compare with similar drugs, it is rigorous that medicine of the present invention has compatibility, mild in medicine property and, feature evident in efficacy, is convenient to large scale application clinically.

Detailed description of the invention

Cyclomastopathy is women's commonly encountered diseases and frequently-occurring disease, multiple with young and middle-aged women, especially with unmarried or do not give birth to, non-suckling and dysthymic women the most easily suffer from this disease.Clinically show as master with mastalgia, lump etc., and how to change with menstrual cycle, feelings will, the factor such as to overwork is relevant.Generally obvious before physiological period occurs, can alleviate or disappear after end cycle.Severe patient can be rest pain, causes Ipsilateral shoulder, axillary fossa, flank, back pain.

Semen Litchi is the dry mature seed of sapindaceous plant Fructus Litchi LitchichinensisSonn..Summer, harvesting ripe fruit, removed peel and meat aril, cleaned, dried.Nature and flavor: sweet puckery, temperature.1. " detailed outline ": " sweet, temperature, puckery, nontoxic." 2. " medical center bun is wanted ": " is sweet puckery, and temperature is micro-salty." 3. " Guangxi Chinese medicinal herbal ": " sweet and slightly bitter taste is puckery, and property is put down, nontoxic." return through: enter liver, kidney channel.1. " detailed outline ": " enter to faint the moon." 2. " Bencao Jingshu ": " enters liver, kidney." 3. " book on Chinese herbal medicine brief points ": " enters lunar, the JUE YIN meridian of foot." function cures mainly: warming middle-JIAO, regulates the flow of vital energy, pain relieving.Control gastric abscess, colicky, women's pricking caused by the stagnation of QI and blood.1. control trusted subordinate's gastral cavilty pain of a specified duration, touch originator repeatly repeatly: Semen Litchi one money, the Radix Aucklandiae eight points.For end.Often take a money, clear soup is taken after mixing with liquid.(Jing-Yue Complete Works litchi perfume is loose) 2. controls pained and small intestine-QI: Semen Litchi one piece.Forge sustainability, wine is taken after mixing with liquid, and it is large as bucket that (amplification on Canon of Materia Medica) 3. controls kidney: Fructus Foeniculi, Pericarpium Citri Reticulatae Viride (full person), Semen Litchi decile on oceangoing ship.File is loose, and fry, going out fire-toxin, is end.Two money under wine, taking medicine three times daily.(Effective Formulas Tested by Physicians for Generations litchi core falls apart) is 4. controlled hernia TUI and is swollen: Semen Litchi four nineteen, and Pericarpium Citri Reticulatae (connecting white) nine money, sulfur four money is end, and it is large that lake, face ball Semen phaseoli radiati bought by saline.When meeting pain, hollow wine takes nine balls, takes for a good while again, also controls all pain due to disorder of QI.(" smooth celestial being all efficacious prescriptions " Yuhuan reflex is red) 5. controls pricking caused by the stagnation of QI and blood: Semen Litchi (charred medicinal herb with its property retained) half two, Rhizoma Cyperi one or two.Upper is end.Often take two money, salt wine send down.

Semen Citri Reticulatae: be the dry mature seed of rutaceae orange CitrusreticulataBlanco and variety thereof.Collect after fruit maturation, clean, dry.Nature and flavor: " detailed outline ": " bitter, flat, nontoxic." return through: enter liver, kidney channel.1. " product remittance essence is wanted ": " the large yin channel of the large the moon of row hands, foot." 2. " detailed outline ": " enters sufficient the moon of fainting." 3. " Bencao Jingshu ": " enters kidney, bladder." function cures mainly: regulate the flow of vital energy, pain relieving.Control hernia, painful and swollen testis, acute mastitis, lumbago, colicky pain of bladder.1. " Japan hanako materia medica ": " control lumbago, bladder gas, kidney aches.Stir-fry is shelled, and wine takes good." 2. " detailed outline ": " controls inguinal hernia and clit swells and ache." 3. essentials of Matea Medica: " row irritability, Sweeling-eliminating medicine powder poison." 4. " medical center bun is wanted ": " profit kidney, hard kidney."

Ramulus Mori: nature and flavor: micro-hardship is flat.Gui Jing: return Liver Channel.Function cures mainly: wind-damp dispelling, sharp joint, row aqueous vapor.Control anemofrigid-damp arthralgia, spasm of the limbs, beriberi edema, human body pruritus due to wind pathogen.1. " Bencao Tujing ": treat all over body pruritus due to wind pathogen dry, beriberi pathogenic wind, spasm of the limbs, upper gas, feels dizzy, and lung qi is coughed, and helps digestion; Diuresis, holds concurrently and treats xerostomia.2. " book on Chinese herbal medicine covers bamboo fish trap ": profit breathes heavily inverse gas ， Xiao burning swelling poison carbuncle of coughing.3. " book on Chinese herbal medicine converges and says ": remove pathogenic wind spasm and pain.4. essentials of Matea Medica: sharp joint, promoting fluid production, row water dispels the wind.5. " beautiful Chinese catalpa medicine solution ": control apoplexy crooked, cough.6. " book on Chinese herbal medicine is new again ": strong lung qi, dampness, kidney nourishing water, stimulates the menstrual flow, cough-relieving relieving restlessness, reducing swelling and alleviating pain.7. " south of the Five Ridges gather medicinal herbs record ": joint wind disease of boning, punish-old year the arthroncus of knee.8. " modern Practical Chinese medicinal ": twig and leaf endure cream clothes, control hypertension, numb hand and foot.

Squama Manis: claim stir-baked SQUAMA MANITIS: catch and kill and take off scale afterwash and dry, drop in the sand of heating, stir-fry to foaming, edge is inwardly curling, and surface is in yellow taking-up.Also effect of vinegar and effect can process use, claim vinegar Squama Manis, stir-baked SQUAMA MANITIS is dropped in vinegar while hot and slightly soaks, pull out dry.Qualitative change thick and hard after big gun is crisp, is easy to pulverize and fried effective ingredient; Processed with vinegar one can be rectified smelly, and two can strengthen promoting blood circulation and stopping pain effect.Meridian distribution of property and flavor: salty, is slightly cold.Return liver, stomach warp.Effect: eliminating carbuncle evacuation of pus of invigorating blood circulation, searches wind active, stimulating milk secretion of stimulating the menstrual flow.Cure mainly carbuncle, sore swollen toxin, anemofrigid-damp arthralgia, blood stasis amenorrhea, lump in the abdomen, galactostasis.

Spica Prunellae: nature and flavor: toil, cold.1. " herbal classic ": " bitter in the mouth is pungent, cold." 2. " not Lu ": " be nontoxic." 3. " book on Chinese herbal medicine is just ": " mildly bitter flavor, micro-pungent." return through: enter liver, gallbladder meridian.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enter liver." 2. " Bencao Jingshu ": " enters sufficient faint the moon, shaoyang channel." function cures mainly: liver heat removing, eliminating stagnation.Control scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia is shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.(1) liver heat removing and eyesight improving: for liver-heat conjunctival congestion and swelling pain, and the headache of excessive rising of liver-YANG, dizzy (as hypertension), Folium Ilicis, Flos Chrysanthemi Indici can be joined.(2) heat clearing away eliminating stagnation: for mastitis, parotitis, can join Radix Bupleuri, Radix Paeoniae Rubra, Bulbus Fritillariae Thunbergii.For scrofula (as tuberculous lymphadenitis), goiter (as simple goiter), often join Concha Ostreae, Bulbus Fritillariae Thunbergii.1. " herbal classic ": " main cold and heat, scrofula, scrofula, head sore, broken disease, loose wart stagnation of QI, swelling of the feet arthralgia chiefly caused by damp pathogen." 2. " Amplification on Materia Medica addendum ": " takes a tonic or nourishing food to build up one's health blood vessels." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " liver-wind of dispelling, network of passing through, controls facial hemiparalysis.Row irritability, opens stagnation of liver-QI, only bones and muscles pain, ophthal malgia, and loose scrofula is stolen, whole body tuberculosis." 4. " the SHENGCAO property of medicine standby want ": " goes expectorant to disappear pus, controls scrofula, clear upper mend under, remove eye mask, pain relieving." 5. " Bencao Congxin ": " controls scrofula, scrofula, goiter, Disorder heavily fortified point, acute mastitis, breast carcinoma." 6. " medicinal herbs among the people of science ": " has diuresis bactericidal action.Decoct can wash wound, controls suppurative outer disease, and washing vagina, controls vaginal orifice and blennometritis." 7. " modern Practical Chinese medicinal ": " is diuretic, effective to gonorrhea, hysteropathy; And can hypertension be controlled, can blood pressure drops be made."

Rhizoma Curcumae: nature and flavor: acrid in the mouth; Bitter; Warm in nature.Gui Jing: return liver, spleen channel.Function cures mainly: circulation of qi promoting removing blood stasis; Removing food stagnancy pain relieving.Main vim and vigour are pained; Eating accumulation; Abdominal distention; Amenorrhea due to stagnation of blood; Dysmenorrhea; Lump in the abdomen tumor mass in the abdomen; Traumatic injury.Pharmacological action: 1, antitumor action: aromatic turmeric oil preparation has the growth of the multiple tumor strains such as the L615 leukemia of Mouse Ehrlich Carcinoma Cells, 615 mouse inbred liness and ascites hepatoma cells in vitro and obviously suppresses and destruction.100% Ah Rhizoma Curcumae injection 0.3-0.5ml injects to mouse peritoneal, to euphorbia egg decoctum.There is good curative effect, inhibitory rate more than 50%.The monomer obtained from Rhizoma Curcumae volatile oil, when curcumenol and curdione 75mg/kg subcutaneous injection, to murine sarcoma S37, cervical carcinomal U14, ehrlich carcinoma (ECA) all have higher suppression ratio, tumor does not obviously reduce person, visible tumor tissue surrounding annulus cytosis, inside has one deck lymphocyte, phagocyte to surround the immunoreation such as tumor cell and occurs.Under Electronic Speculum, treatment group tumors cells show nucleo-cytoplasmic ratio reduces, and core profile trend is normal, and chromatin, kernel and interchromatin granule quantity reduce, therefore think that the nuclear metabolism of Rhizoma Curcumae to murine sarcoma has inhibitory action.In vitro tests proves that curcumenol and curdione have obvious destruction to ehrlich ascites cell, can make its degeneration necrosis.The Oleum Curcumae injection of variable concentrations all has significantly directly destruction to oncocyte, and have the feature that effect is fast and strong, oncocyte number is more, kill 90% the liquor strength needed for oncocyte larger.The existing direct effect of mode of Rhizoma Curcumae antitumaous effect, also has the immunoreation of host to participate in.Clinically make intratumoral injection cervical cancer with Oleum Curcumae, after treatment, visible tumor tissue necrosis comes off, and local lymphocytes infiltrates, and some cases lump disappears, and cervix uteri is smooth, and prompting Rhizoma Curcumae has the effect of directly killing oncocyte.

In pathological section, then see intensive small lymphocyte around cancerous cell, have a large amount of hole cell tissue propagation in lymphatic sinusoid, lymphocytes in blood has the rising shown, and these all point out host in effective case to have obvious immunoreation.The principle of Rhizoma Curcumae antitumaous effect, outside the direct cytotoxicity of Oleum Curcumae decapacitation, can also strengthen oncocyte immunogenicity, thus brings out or promote that body is to the immunological rejection of tumor, experiment proof ECA and L615 of Rhizoma Curcumae process.Tumor vaccine carries out active immunity, and Some Animals really can be made to obtain obvious protective effect.Further research proves that the active immunity protective effect of Rhizoma Curcumae L615 tumor strain has certain specificity; because through the animal of Rhizoma Curcumae L615 tumor immunity, the Cross immunogenicity effect to L795 (the sarcoma leukemia that the strain of to be 615 be mice is new) can not be produced.Some have the Rhizoma Curcumae tumor vaccine immune group animal of obvious immunity to L615, although can tolerate the multiple attack of 10 (-3) × 10 L615 cell, die from 3 × 10 L759 oncocytes.And this immunoprotective effec has certain stability; once after setting up; the time of quite long (10-13 month) can be maintained; but can not filial generation be passed to; because its filial generation overwhelming majority (93/94) can not tolerate the attack of a 105-3 × 105 L615 cell; typical L615 all occurs, leukemia and dead, mean survival time also has no prolongation, illustrates that the day after tomorrow this immunoprotective effec of parental generation obtain and can not pass to filial generation.Oleum Curcumae is observed to the radiosensitizing effect of adenocarcinoma of lung (LA-795) with the female T-739 mice of pure lines, the results show, add irradiation group with Oleum Curcumae lumbar injection and have obvious tumor growth delay effect than simple irradiation group, the effect of radiation therapy can be made to improve 42%, reach medium sensitization.2, antiearly pregnancy effect: the alcohol extractum of Rhizoma Curcumae rhizome and effective ingredient (monoterpenes and sesquiterpenoids) thereof have to rat, mice the antiearly pregnancy effect shown very much, also have certain anti-implantation effect to dog.Show most with the only pregnant effect of Oleum Curcumae, little haze lumbar injection and subcutaneous injection 600-900mg/kg Oleum Curcumae, its anti-implantation and antiearly fertility effect is 7%-90%, rabbit lumbar injection 80mg/kg Oleum Curcumae, anti-implantation effect is 80%, and the anti-implantation effect of transvaginal injection 400mg/kg is 100%, generally in administration in 2-5 days of becoming pregnant, namely there is embryonic death, absorb or stop blast implantation.Administration in 7-10 days of becoming pregnant then causes miscarriage or stillborn fetus, volatile oil all has certain only pregnant effect through subcutaneous, abdominal cavity, vagina administration, just drug effect speed is inconsiderate to some extent. and lumbar injection is rapid-action, and vagina administration onset is slow, and intraperitoneal administration amount is less than vagina administration amount 5 times.Decoct sharp gavage mice from Rhizoma Curcumae, have only pregnant effect equally.Oleum Curcumae stops pregnant process to mice and is prevention blast implantation, makes it stasi, and the blast that visible atrophy is degenerated is free in uterine cavity, dead after some blast implantations, is in by absorption process.3, antibacterial action: Rhizoma Curcumae volatile oil in vitro can suppress staphylococcus aureus.The growth of beta hemolytic streptococcus, escherichia coli, Bacillus typhi, vibrio cholera etc.4, the effect of leukocyte increasing: mouse peritoneal injection Oleum Curcumae 10ml/kg, curcumenol 0.3%10ml/kg, after continuous 8d, obviously can resist the leukopenia caused by abdominal cavity shot cyclophosphamide 150mg/kg, and promoting that leukocyte gos up, prompting Rhizoma Curcumae has certain function of increasing leukocyte.5, to cardiovascular effect: it is the most obvious that Rhizoma Curcumae increases acting in drug for invigorating blood circulation and eliminating stasis of femoral artery blood flow, blood flow peak value increases by 252%, medication is blood flow increase by 36.0% after 10 minutes, vascular resistance reduces 66.4%, with the blood stasis patient of Oleum Curcumae injection intravenous drip treatment thromboangiitis obliterans, along with the improvement of patients clinical symptom, Limb rheogram also sees obvious improvement.6, on the impact of gastrointestinal smooth muscle: the test of isolated rabbit intestinal finds, low concentration Rhizoma Curcumae, makes intestinal tube tensity raise, and during high concentration, makes intestinal tube diastole on the contrary.7, hepatoprotective effect: curcumenol extract and volatile oil raise the mice alanine aminotransferase (ALT) that carbon tetrachloride (CCI4) thioacetamide (TAA) causes obvious reducing effect, sulfobromophthalein sodium (BSP) retention amount is reduced, and corresponding liver tissue lesions alleviates.8, effect to acute renal failure: rabbit 50% glycerol saline 15ml/kg subcutaneous injection causes acute renal failure, increase that the visible renal swelling of matched group naked eyes is swollen, in purple dark-coloured, intravital microscope low power lens is observed, visible more being retarded by silt in purple dark-coloured strip blood vessel, capillary blood flow is stagnated or is slowed down, vein is to Rhizoma Curcumae injection 4ml/kg every day, after totally 3 days, naked eyes have no kidney obvious tumefaction, purple dead color subtracts shallow or has recovered normal, under live body mirror, visible strip blood vessel stasis disappears, capillary blood flow is accelerated pathological section (FIE) matched group and is seen there is nearly song widely, Distal convoluted tubule epithelial cell vacuolar degeneration or cloudy swelling, renal tubules obliteration, part tubular epithelial destroys and comes off, comparatively multi-pipe type is had to exist in tube chamber, part Ink vessel transfusing has blood stasis, after Zedoary injection, 48 hours above-mentioned pathological changes all obviously alleviate, the epithelial cell cavity of curved tube and cloudy swelling show and alleviate, the cast of renal tubules intracavity is few or disappear, blood stasis in thin vessels reduces or disappears, glomerular capillary tube chamber expands.Within after general rabbit glycerol injection about 12 hours, there is red sauce urine, urine volume shows and to reduce, some anurias, listless, do not eat, all dead in 24-48 hour, and Rhizoma Curcumae group hydrouria after 24 hours, though urine color is also in red sauce, after 48-72 hour, urinate this recovery of color base faint yellow, there is no death.9, anticoagulant and antithrombus formation: Rhizoma Curcumae aqueous extract has to the platelet aggregation of ADP induction the inhibitory action shown in totally 7 days, and obviously can reduce blood viscosity to rat oral gavage, and shorten erythrocytic electrophoresis time for 9.0g/kg/ days.Its water extract-alcohol precipitation injection 1.13g/kg intravenous injection is formed rat thrombus in vivo also the inhibitory action shown very much.10, antiinflammatory action: the peritonitis that mouse gavaging the essential oil from Curcuma wenyujin 200mg/kg Dichlorodiphenyl Acetate produces has the inhibitory action shown very much, mouse peritoneal injection the essential oil from Curcuma wenyujin 200mg/kg has obvious inhibitory action to scald property local edema, lumbar injection 100m/kg has obvious inhibitory action to the ear inflammation that Oleum Tiglii causes, rats by intraperitoneal injection volatile oil 75mg/kg/ days, had obvious inhibitory action to subcutaneous granuloma induced by implantation of cotton pellets hypertrophy after 9 days.11, physiological disposition: 3H-curcumenol oral absorption is complete rapidly, can measure this product, reach peak in 15 minutes, can maintain l hours, half-life t1/2 for after rats gavaged 5 minutes in blood.Be 33 minutes, t1/2 β is 12.5 hours.Distribution in vivo is the highest with liver, kidney concentration, and be 2-2.5 times of its hetero-organization, and can pass through blood brain barrier, mainly from homaluria, bile also has excretion.There is hepato-enteric circulation phenomenon.12, toxicity: curcumenol extract, the median lethal dose(LD 50) of Mouse oral is 86.8 ± 12g (crude drug)/kg.

Rhizoma Cyperi: nature and flavor: pungent micro-hardship is sweet, flat.1. " not Lu ": " sweet in the mouth, is slightly cold, nontoxic." 2. amplification on Canon of Materia Medica: " bitter in the mouth." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " slightly warm in nature, acrid in the mouth." 4. " detailed outline ": " gas is put down, and the micro-hardship of acrid in the mouth is micro-sweet." return through: enter liver, tri-jiao channel.1. " detailed outline ": " brothers are silent cloudy, the few sun of hands, and row 12 of holding concurrently is through, eight arteries and veins edema caused by disorder of QI." 2. " Thunder God concocts property of medicine solution ": " enters lung, liver, spleen, stomach four warp." function cures mainly: resolving depression of regulating the flow of vital energy, pain relieving regulating menstruation.Treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.(1) to regulate the flow of vital energy resolving depression: for the breast side of body and the stomach abdominal distention and pain of depression of liver-QI.Join Radix Bupleuri, Pericarpium Citri Reticulatae Viride controls chest and hypochondrium.Join Rhizoma Alpiniae Officinarum (name Liang Fu Wan) and control cold syndrome of the stomach pain.(2) menstruction regulating and pain relieving: for menoxenia, the lower abdominal distention pain of depression of liver-QI.Join the menalgia that Folium Artemisiae Argyi controls QI stagnated by cold.1. " not Lu ": " main except feverish sensation in the chest, fill fur, take sharp people for a long time, QI invigorating, long man." 2. Tang Materia Medica: " large therapeutic method to keep the adverse QI flowing downwards, except breast heat in the abdomen." 3. " medicine origin ": " fast gas." 4. Li Gao: " controls all gas, and the stomachache and cholera is vomited and diarrhoea, kidney qi, bladder is cold, removing stagnancy of indigested food and making QI downward." 5. Materia Medica of Decoction: " controls metrorrhagia." 6. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " adjusts the gas in blood, and dissipating depression of QI, alleviating distention in middle-JIAO, helps digestion, anti-nausea." 7. " detailed outline ": " loose seasonal epidemic pathogens is trembled with fear epidemic disease, and profit three is burnt, and separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, the moon wait uncomfortable, before tire puerperal all kinds of diseases and ailments."

Pericarpium Citri Reticulatae Viride: nature and flavor: toil, tepor. 1. " Bencao Tujing ": " bitter in the mouth." 2. " medicine origin ": " temperature, acrid in the mouth." curing mainly secret formula " cloud, cold in nature, bitter in the mouth.The pungent micro-acid of " 3. " about can cure mirror ": " bitter in the mouth." return through: enter liver, gallbladder meridian. 1. Li Gao: " foot faints the guiding drug of the moon, shaoyang channel." 2. Materia Medica of Decoction: " meridian of Foot-JUE YIN guiding drug, enters meridian of Hand-SHAO YANG again." 3. " Thunder God concocts property of medicine solution ": " enters liver, spleen two warp." 4. " book on Chinese herbal medicine is through separating ": " enters liver channel of foot-Jueyin, lung meridian, heart channel of Hand-Shaoyin." function cures mainly: soothing the liver dispelling the stagnated QI, eliminating stagnation expectorant.Control breast side of body gastralgia, hernia, food stagnation, swelling of the breast, nodule in the breast, chronic malaria addiction block.1. " Bencao Tujing ": " the main stagnation of QI, lower food, removing mass knot and diaphragm gas." 2. " medicine origin ": " " curing mainly secret formula " cloud, dividing of the moon of fainting, few sun illly uses it.Broken hard addiction, loose stagnant gas, go the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels all wet, left flank has pneumatosis." 3. " detailed outline ": " controls chest and diaphragm QI rising in reverse order, hypochondriac pain, lower abdomen hernia, and disappear swelling of the breast, soothing the liver gallbladder, eliminating the pathogens from the lung gas." 4. essentials of Matea Medica: " expectorant disappears painful abdominal mass, controls depression of liver-QI, the many anger of hypochondriac pain, chronic malaria knot addiction, colic, swelling of the breast." 5. " modern Practical Chinese medicinal ": " treats for stomachache, and tells inverse, antipyretic, expectorant water."

Bulbus Fritillariae Thunbergii: nature and flavor: " book on Chinese herbal medicine is just ": " the large hardship of taste, cold in nature." return through: " book on Chinese herbal medicine just ": " starts with lunar, few sun, bright, the moon of fainting of foot sun." function cures mainly: removing heat-phlegm, powder detoxifcation.Control cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, sore swollen toxin.1. " book on Chinese herbal medicine is just ": " control greatly lung abscess lung to wither, cough with asthma, spit blood, mental disorder, falls most in epistaxis, kind relieving stagnation, and relieve the pain pain, and relieving distension is full, clearing away liver-fire, improve visual and auditory acuity, except seasonal epidemic pathogens dysphoria with smothery sensation, jaundice stranguria with urinary obstruction, hematuria of having blood in stool; Relieving heat toxin, kill parasites and treat sore throat, scrofula, acute mastitis carbuncle on the back, all carbuncle and ulcer toxic swellings, damp and hot malignant boil, anal fistula, incised wound is hemorrhage, burn pain, and than Bulbus Fritillariae Cirrhosae, the merit of falling clearly, not less than several times.Wind-phlegm is felt when " 2. " Bencao Congxin ": " goes." 3. " detailed outline is picked up any lost article from the road ": " detoxify sharp expectorant, opens lung qi dispersing gas, and all lung men folder wind-fire has expectorant, and person should this." 4. " Shandong Chinese herbal medicine handbook ": " removing heat from the lung and dissipating phlegm, antacid, removing toxic substances.Cure cold cough, and stomachache acid regurgitation, carbuncle poison swells and ache."

Poria: nature and flavor: sweet light is flat.1. " herbal classic ": " sweet in the mouth is flat." 2. " medicine origin ": " " curing mainly secret formula " cloud, warm in nature, lightly seasoned." return through: enter the heart, spleen, lung meridian.1. Materia Medica of Decoction: " start with large cloudy, the large sun of foot, shaoyang channel." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " enters bladder, kidney, lung." 3. " Thunder God concocts property of medicine solution ": " enters lung, spleen, small intestinal three warp.It is few cloudy that " 4. " Bencao Jingshu ": " enters brothers, the hands sun, lunar, the Yangming Channel of foot." function cures mainly: eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.1. " herbal classic ": " the inverse gas of the main breast side of body, melancholy is angerd frightened heresy and probably throbbed with fear, knot pain under the heart, cold and heat stuffy sensation with restlessness, cough with dyspnea, the burnt dry tongue of mouth, diuresis." 2. " not Lu ": " only quenches one's thirst, and likes to sleep, and large abdomen drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema drenches knot.Open breast internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, physical strength profiting, during guarantor god keeps." 3. " property of medicine opinion ": " whets the appetite, and preventing or arresting vomiting is inverse, kind tranquilizing mind.Main consumptive lung disease expectorant is stopped up.Control pediatric epilepsy scared, trusted subordinate's distension, married woman's pyretic stranguria." 4. " Japan hanako materia medica ": " mends five kinds of strain and seven kinds of impairment, antiabortive, warm waist knee joint, and happy Fructus Alpiniae Oxyphyllae is only forgetful.The slow spleen of " 5. " concise exposition on febrile disease ": " infiltration."

Radix Bupleuri: nature and flavor: bitter, is slightly cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.Radix Bupleuri one medicine, have light clear rise loose, again can the feature of catharsis.Can expelling pathogenic factors from the exterior bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, can be used for again elevate a turnable ladder yang-energy.Therefore, it is both can be used for the case of a physically strong patient running a high fever simply clinically, can be used for again the medicine of deficient syndrome.Its various different effect can be played due to compatibility difference, as: join Radix Puerariae, Rhizoma Et Radix Notopterygii, then relieving the exterior syndrome by diaphoresis; Join Radix Scutellariae, Herba Artemisiae Annuae, then expelling pathogenic factors from the exterior expels the heat-evil; Join Radix Dichroae, Fructus Tsaoko, then preventing the attack (or recurrence) of malaria is brought down a fever; Join Rhizoma Cyperi, Radix Curcumae, then dispersing the stagnated live-QI to relieve the stagnation of QI; Join Radix Codonopsis, Radix Astragali, Bai Intraoperative, Rhizoma Cimicifugae etc., then elevate a turnable ladder yang-energy.But cloudy thanks to Tianjin is few and excessive rising of liver-YANG person should not apply.Radix Bupleuri and Radix Puerariae, gently the clear function of faling apart that rises is similar, therefore often same using of bringing down a fever of inducing sweat.But respectively have speciality, Radix Bupleuri energy dispersing the stagnated live-QI to relieve the stagnation of QI, joining resistance and supplementing qi medicine can ascending up spleen-Qi and Yang, for uterine prolapse, proctoptosis, so without promoting the production of body fluid the merit of quenching one's thirst; Radix Puerariae has promoting the production of body fluid to quench thirst effect, and energy hair growth promoting is positive clearly, for watery diarrhea, so without dispersing the stagnated live-QI to relieve the stagnation of QI function.

Semen Vaccariae: nature and flavor: bitter is flat.1. " herbal classic ": " bitter in the mouth is flat." 2. " WU Pu Bencao): " qi primary, Thunder God: sweet." 3. " not Lu ": " be sweet, flat, nontoxic." 4. " book on Chinese herbal medicine is just read ": " is bitter and pungent, flat." return through: enter liver, stomach warp.1. " detailed outline ": " sun bright, punching, appoint." 2. " Thunder God concocts property of medicine solution ": " popular feeling, liver two warp." function cures mainly: promoting the circulation of blood is stimulated the menstrual flow, and expedites the emergence of stimulating milk secretion, detumescence sore.Control women's amenorrhea, galactostasis, difficult labour, stranguria with blood, carbuncle, incised wound is hemorrhage.To stimulate the menstrual flow stimulating milk secretion: for amenorrhea and agalactia.It is many and obstructed that Semen Vaccariae controls milk; As the deficiency syndrome of hypogalactia, then need the medicine of adapted benefiting vital QI and blood.Promoting blood circulation and detumescence: for blood stasis lump and sore and toxic.1. " herbal classic ": " main incised wound is stopped blooding by pain, gone out thorn, except migratory arthralgia endogenous cold." 2. " not Lu ": " only vexed epistaxis, carbuncle malignant boil, fistula breast, married woman has difficult labour." 3. " property of medicine opinion ": " controls pathogenic wind toxic, promoting blood circulation." 4. " Japan hanako materia medica ": " controls carbuncle on the back, urticaria, rubella, and married woman's blood is through irregular and difficult labour." 5. " pearl sac ": " You guides, and sharp skin infection, cures mainly dysentery." 6. " detailed outline ": " diuresis." 7. " Bencao Congxin ": " controls furuncle."

Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Sanguis Draxonis: nature and flavor: Gan Xian is flat.1. Lei Gong's Treatise on Preparation and Broiling of Materia Medica: " taste is micro-salty sweet." 2. Tang Materia Medica: " sweet-salty is flat, slightly poisonous." 3. " book on Chinese herbal medicine covers bamboo fish trap ": " acrid in the mouth is salty, and gas is put down, slightly poisonous." return through: enter the heart, Liver Channel.1. " detailed outline ": " brothers faint the moon." 2. " Bencao Jingshu ": " enters sufficient the moon of fainting, meridian of Hand-SHAO YIN." 3. " book on Chinese herbal medicine is newly organized ": " enters kidney." function cures mainly: dissipating blood stasis analgesic therapy, hemostasia and promoting granulation.Control traumatic injury to lose, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time.1. Tang Materia Medica: " main the five internal organs pathogen, leukorrhagia, pain relieving, removing mass blood, gold creation meat." 2. " Haiyao Bencao, Oversea Materia Medica ": " is leading traumatics fracture damage, all pain, and tonify deficiency and vim and vigour stir thorn, and interior blood trouble is gathered, and should wine clothes." 3. " Japan hanako materia medica ": " is controlled all malignant boil scabies and is not conformed to person for a long time, applies.This property of medicine is anxious, also can not make more, but draw pus." 4. Wang Haogu: " reinforcing the heart envelope, deficiency of liver-blood." 5. " detailed outline ": " falls apart all pains of stagnant blood, married woman's vim and vigour, children's Chi Zong."

Olibanum: nature and flavor: arduous, temperature.1. " not Lu ": " tepor." 2. " Japan hanako materia medica ": " acrid in the mouth, heat, micro-poison." 3. Li Gao: " bitter in the mouth is pungent, heat." return through: enter the heart, liver, spleen channel.1. Zhu Zhenheng: " enter meridian of Hand-SHAO YIN.It is few cloudy that " 2. " Bencao Jingshu ": " enters lunar, the hands of foot, double enter meridian of Foot-JUE YIN." function cures mainly: regulating qi and activating blood, and analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.1. " not Lu ": " treat edema due to wind pathogen poison swollen, remove bad odor." " is treated urticaria and to be itched poison." 2. supplement to the Herbal: " is treated deaf, apoplexy locked mouth, and married woman's vim and vigour, can send out wine, manage air-cooled, and only large intestine lets out Bleach, treats all skin ulcers and makes internal diabetes." 3. " Japan hanako materia medica ": " be cholera only, cardiac and abdominal pain.Soft extracts pain relieving is put on flesh." 4. " Zhenglei Bencao ": " controls sleeplessness." 5. " pearl sac ": " fixed all warps pain." 6. " detailed outline ": " all poison of eliminating carbuncle cellulitis, the heart is protected in Tuoli, and analgesic therapy of invigorating blood circulation, stretches muscle, controls married woman's difficult labour, injured." 7. " Bencao Congxin ": " is controlled demented, stopping leak dysentery."

The Radix Paeoniae Alba: nature and flavor: picric acid is cool.1. " herbal classic ": " bitter in the mouth is flat." 2. " WU Pu Bencao ": " paulownia monarch: sweet, nontoxic.Qi primary: salty.Li Shi: Slight Cold.Thunder God: acid." 3. " not Lu ": " acid, is flatly slightly cold, slightly poisonous." return through: enter liver, spleen channel.1. " product remittance essence is wanted ": " row hands is lunar, meridian of Foot-TAI YIN." 2. " Bencao Jingshu ": " lunar guiding drug of brothers, enters liver, spleen blood system." function cures mainly: nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.1. " herbal classic ": " main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, control cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." 2. " not Lu ": " clear and coherent blood vessels, in slow, dispelling malignant blood, expelling extravasated blood, anhydrate gas, sharp bladder, intestine and small intestine, subduing inflammation, row cold and heat time (controlling), and attacked by pestiferous factors is suffered from abdominal pain, lumbago." 3. " property of medicine opinion ": " controls pathogen of the lung gas, Fu Zhong Xu pain, and vim and vigour are gathered, and logical a surname's internal organs gather around gas, controls evil pain deteriorated blood, and disease bone heat time main, strong the five internal organs, the kidney invigorating gas, controls trusted subordinate's heavily fortified point swollen, and married woman's blood closes obstructed, and repercussive blood can lose pus." 4. Tang Materia Medica: " beneficial woman's blood."

The Rhizoma Pinelliae: nature and flavor: pungent, temperature, poisonous.1. " herbal classic ": " pungent, flat." 2. " not Lu ": " be raw to be slightly cold, and ripe temperature is poisonous." 3. " property of medicine opinion ": " is very toxic." 4. " Japan hanako materia medica ": " acrid in the mouth." 5. (medicine origin ": " " curing mainly secret wanting " cloud, warm in nature, acrid in the mouth is bitter.Gui Jing: enter spleen, stomach warp.1. Materia Medica of Decoction: " enter bright, lunar, the shaoyang channel of foot sun." 2. " Thunder God concocts property of medicine solution ": " enters lung, spleen, stomach three warp." 3. " Bencao Jingshu ": " enters foot too bright, the few sun of yin, yang, meridian of Hand-SHAO YIN." 4. " book on Chinese herbal medicine converges and says ": " bright, lunar, few cloudy three warps of sun of starting with." 5. " book on Chinese herbal medicine is new again ": " enters liver, spleen, lung three warp." function cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness.Outer subduing inflammation., vomiting regurgitation dizzy for abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, interior expectorant, breast gastral cavity painful abdominal mass are vexed, globus hystericus disease; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.

Radix Codonopsis: nature and flavor: sweet is flat.1. " herbal classic is met former ": " sweet, flat." 2. " book on Chinese herbal medicine is new again ": " is sweet, flat, nontoxic." return through: " must join book on Chinese herbal medicine ": " starts with, meridian of Foot-TAI YIN edema caused by disorder of QI." function cures mainly: invigorating middle warmer, and QI invigorating is promoted the production of body fluid.Control weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.1. " herbal classic is met former ": " lung heat clearing." 2. " Bencao Congxin ": " invigorating the spleen and replenishing QI, and taste, relieving thirst and restlessness." 3. " detailed outline is picked up any lost article from the road ": " controls the deficiency of the lung, lung benefiting gas." 4. " medicinal herbs among the people of science ": " hematinic.Be applicable to chronic anaemia, chlorosis, leukemia, adenopathy, rickets." 5. " Chinese crude drug handbook ": " controls asthenia internal injury, intestinal cold in the stomach, slides and rushes down chronic dysentery, asthma excessive thirst, and heating spontaneous perspiration, metrorrhagia, tire produce all diseases."

Caulis Spatholobi: nature and flavor: bitter sweet, temperature.1. " decoction pieces is newly joined ": " pained fragrant micro-sweet." 2. " book on Chinese herbal medicine justice ": " temperature." 3. Jiangxi " Chinese herbology ": " bitter temperature is micro-sweet." return through: " book on Chinese herbal medicine is new again ": " enters the heart, spleen two warp." function cures mainly: invigorate blood circulation, relaxing muscles and tendons.Control soreness of waist and knee joint, paralysis and numbness, menoxenia.1. " detailed outline is picked up any lost article from the road ": " invigorate blood circulation, warm waist knee joint, paralysis." 2. " book on Chinese herbal medicine is new again ": " dry stomach of invigorating middle warmer." 3. " decoction pieces is newly joined ": " blood stasis removing blood, tissue regeneration promoting blood, fluent passages through which vital energy circulates.Control summer filthy infection, wind arthralgia due to stagnation of blood disease.The hematonic that " 4. " modern Practical Chinese medicinal ": " is robustness, is applicable to anemicus neural paralysis disease, as limbs and soreness of waist and knee joint, apathetic etc.Again for menoxenia, menstruation apolipsis etc., have the effect of invigorating blood circulation analgesia."

Fructus Ligustri Lucidi: nature and flavor: bitter sweet, flat.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be sweet, nontoxic." return through: enter liver, kidney channel.1. " Bencao Jingshu ": " enter meridian of Foot-SHAO YIN." 2. " book on Chinese herbal medicine is new again ": " enters liver, lung, kidney three warp." function cures mainly: invigorating the liver and kidney, strong waist knee joint.Control yin asthenia generating intrinsic heat, dizzy, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.

Fructus Lycii: nature and flavor: sweet, flat.1. " not Lu ": " be slightly cold, nontoxic." 2. " property of medicine opinion ": " sweet in the mouth is flat." 3. " Treatise on Dietetic Therapy ": " trembles with fear, nontoxic." return through: enter liver, kidney channel.1. " book on Chinese herbal medicine converges and says ": " enter few cloudy, the meridian of Foot-JUE YIN of foot." 2. " book on Chinese herbal medicine is through separating ": " enters kidney meridian, heart channel of Hand-Shaoyin." 3. " key medicine divides agent ": " enters liver, stomach two warp, double enter lung meridian." function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.1. TAO Hong-Jing: " nourishing the essence and strengthening QI, prosperous and powerful vagina." 2. " property of medicine opinion ": " energy tonification essence various symptoms and signs of deficiency, easy color, bleaches, and improving eyesight is calmed the nerves." 3. " Treatise on Dietetic Therapy ": " hard muscle is always resistance to, and except wind, tonification muscles and bones, the beneficial people of energy, removes asthenia." 4. Wang Haogu: " main cardiopathia dry sensation in the pharynx, pained, taking fluids profusely yearningly, during nephropathy disappears." 5. " detailed outline ": " nourishing kidney, lung moistening, improving eyesight." 6. " book on Chinese herbal medicine is stated ": " treats liver-wind blood deficiency, the confused nebula of eye red sufferings.It is dizzy that " " controls apoplexy, asthenia, allly sees blood disorder, cough blood, flaccidity, faint, contraction, diseases due to endogenous heat of ZANG FU organs, hinders dry, seminal emission, reddish and whitish turbid urine, beriberi, the arthroncus of knee."

Herba Leonuri: nature and flavor: arduous, cool.1. supplement to the Herbal: " cold." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " acrid-sweet flavor, feeble QI temperature, nontoxic." 3. " detailed outline ": " micro-hardship of acrid in the mouth, nontoxic." 4. " book on Chinese herbal medicine just ": " mildly bitter flavor, micro-pungent.Be slightly cold, property is sliding." return through: enter pericardium, Liver Channel.1. " book on Chinese herbal medicine converges and says ": " hands, meridian of Foot-JUE YIN." 2. " medicineization justice ": " enters liver, spleen, envelope three warp." 3. " book on Chinese herbal medicine is new again ": " enters the heart, spleen, kidney three warp." function cures mainly: invigorate blood circulation, blood stasis dispelling, regulating menstruation, and disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.

Rhizoma Alismatis: nature and flavor: sweet, cold.1. " herbal classic ": " sweet in the mouth, cold." 2. " not Lu ": " be salty, nontoxic." 9. " property of medicine opinion ": " bitter in the mouth." 4. " medicine origin ": " gas is put down, sweet in the mouth." 5. " book on Chinese herbal medicine covers bamboo fish trap ": " sweet acid, gas is trembled with fear." return through: enter kidney, urinary bladder channel.1. Materia Medica of Decoction: " sun of starting with, shaoyin channel." 2. " Amplification on Materia Medica is mended L and lost ": " enters the sufficient sun, shaoyin channel." 3. " Thunder God concocts property of medicine solution ": " enters bladder, kidney, three burnt, small intestinal four warps." 4. " book on Chinese herbal medicine is through mercapto ": " enters kidney, spleen." function cures mainly: diuretic, and eliminating dampness by diuresis expels the heat-evil.Control dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.

The Rhizoma Atractylodis Macrocephalae: nature and flavor: bitter sweet, temperature.1. " herbal classic ": " bitter in the mouth, temperature." 2. " not Lu ": " be sweet, nontoxic." 3. " property of medicine opinion ": " sweet in the mouth is pungent, nontoxic." return through: enter spleen, stomach warp.1. " the Decoction and Material Medica": " sun of starting with, Shao Yin, foot sun is bright, lunar, few cloudy, JUE YIN meridian." 2. " book on Chinese herbal medicine covers bamboo fish trap": " enter the heart, spleen, stomach, three burnt four warps." function cures mainly: spleen reinforcing, stomach reinforcing, dampness, and in, antiabortive.Control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.

Radix Glycyrrhizae: nature and flavor: sweet, flat.1. " herbal classic ": " sweet in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. " amplification on Materia Medica": " micro-cool." 4. " pearl sac ": " is raw sweet, flat; Process sweet, temperature." return through: enter spleen, stomach, lung meridian.1. " the Decoction and Material Medica": " enter sufficient cloudy, lunar, shaoyin channel of fainting." 2. " thunder God big gun pharmacy solution": " enter the heart, spleen two warp." 3. " explaining abstruseness of the canon of materia medica ": " enters spleen, stomach." 4. " book on Chinese herbal medicine is through separating": " enter lung meridian, spleen meridian." function cures mainly: with middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Process use, control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, infantile convulsion; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.

Semen Cassiae: nature and flavor: bitter sweet, cool.1. " herbal classic ": " salty in the mouth is flat." 2. " not Lu ": " be bitter sweet, is slightly cold, nontoxic." 3. " book on Chinese herbal medicine just ": " mildly bitter flavor is micro-sweet, and property is put down, micro-cool." return through: enter liver, kidney channel.1. " Thunder God concocts property of medicine solution ": " enter Liver Channel." 2. " Bencao Jingshu ": " liver meridian, also enters gallbladder, kidney." function cures mainly: liver heat removing, improving eyesight, diuretic, relieving constipation.Control wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, cirrhotic ascites, habitual constipation.1. " herbal classic): " control optic atrohic blindness, the red tunica albuginea of the excessive skin of order, swelling ophthalmalgia, lacrimation, clothes benefit is with nothing left for a long time." 2. " not Lu ": " treats blue-purple lips." 3. " property of medicine opinion ": " sharp the five internal organs, except liver man warm." 4. " Japan hanako materia medica ": " helps irritability, beneficial smart water; Adjust end to be coated with, detumescence poison, Xie temple control headache, paste again the brain heart and stop epistaxis; Make pillow victory Semen sojae atricolor, control wind syndrome of head, improving eyesight." 5. " Amplification on Materia Medica addendum ": " antidotes against snake bite." 6. " the SHENGCAO property of medicine is standby to be wanted ": " controls children's's five kinds of child malnutrition, wipes tinea leprosy." 7. " medical center bun is wanted ": " rushes down evil water." 8. " Hunan medicine will): " improving eyesight, diuresis.Control giddy, beriberi, edema, lung abscess, the thoracic obstruction." 9. Guangzhou army " conventional Chinese herbal medicine handbook ": " liver heat removing and eyesight improving, diuretic relieving constipation.Treating the liver is scorching, cirrhotic ascites, hypertension, infantile malnutrition, nyctalopia, wind heat ophthalmalgia, habitual constipation."

Fructus Trichosanthis: nature and flavor: sweet, micro-hardship, cold.Gui Jing: return lung, stomach, large intestine channel.Function cures mainly: clearing away heat and eliminating phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.

Herba Taraxaci: nature and flavor: bitter sweet, cold.1. Tang Materia Medica: " sweet in the mouth is flat, nontoxic." 2. Li Gao: " micro-hardship, cold." 3. " book on Chinese herbal medicine is stated ": " is sweet, puts down and is slightly cold." 4. Guangzhou army " conventional Chinese herbal medicine handbook ": " is bitter sweet, cold." return through: enter liver, stomach warp.1. Li Gao: " meridian of Foot-SHAO YIN." 2. " Amplification on Materia Medica addendum ": " enters bright, the Taiyin channels of sun." function cures mainly: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.

Flos Lonicerae: nature and flavor: sweet, cold.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cold in nature, bitter in the mouth." 2. " book on Chinese herbal medicine just ": " sweet in the mouth, gas is put down, its cold nature." return through: enter lung, stomach warp.1. " Thunder God concocts property of medicine solution ": " enter lung meridian." 2. " must join book on Chinese herbal medicine ": " enters bright, the Taiyin channels of foot sun." function cures mainly: heat clearing away, removing toxic substances.Control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " heat clearing away, separates all skin ulcers, carbuncle carbuncle on the back, red stream scrofula." 2. " the SHENGCAO property of medicine is standby to be wanted "; " energy eliminating carbuncle cellulitis furunculosis, dysentery relieving disease, washes chancre, peeling skin heat in blood." 3. essentials of Matea Medica: " nourishes blood and quenches the thirst.Control scabies.In " 4. " Chongqing hall random notes ": " clear network, wind-fire is damp and hot, separates the dirty filthy heresy of pestilence, and breath liver and gall floating more wind sun, controls all diseases of convulsion syncope and insanity epilepsy." 5. Guangzhou army " conventional Chinese herbal medicine handbook ": " heat-clearing and toxic substances removing.Control fever caused by exogenous pathogens cough, enteritis, bacillary dysentery, measles, parotitis, septicemia, furuncle toxic swelling, appendicitis, trauma infection contamination, children's's hidradenitis suppurativa.Make herbal tea, heatstroke, flu and infectious intestinal disease can be prevented."

Cortex Acanthopancis: nature and flavor: pungent, temperature.1. " herbal classic ": " acrid in the mouth, temperature." 2. " not Lu ": " be bitter, is slightly cold, nontoxic." 3. " property of medicine opinion ": " is slightly poisonous." 4. " medical center bun is wanted ": " is bitter micro-pungent, cold." 5. " Traditional Chinese Medicine in Sichuan will ": " is warm in nature, and sweet in the mouth is nontoxic." return through: enter liver, kidney channel.1. " Thunder God concocts property of medicine solution ": " enter lung, kidney two warp." 2. " Bencao Jingshu ": " enters few cloudy, the JUE YIN meridian of foot.Function cures mainly: wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt.Control anemofrigid-damp arthralgia, muscles and bones contraction is anxious, lumbago, sexual impotence, flaccidity of the lower limbs, children's's walking retardation in children, edema, beriberi, skin ulcer cellulitis toxic swelling, traumatic injury impairment caused by overstrain.

Fructus Forsythiae: nature and flavor: bitter, cool.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. " medicine origin ": " " curing mainly secret formula " cloud, cool in nature, bitter in the mouth." 4. " detailed outline ": " micro-toil." return through: enter the heart, liver, gallbladder meridian.1. Materia Medica of Decoction: " the few sun of brothers, Yangming Channel." 2. " detailed outline ": " few cloudy heart channel, Yinpao (Liv 9) network edema caused by disorder of QI of fainting." 3. " Thunder God concocts property of medicine solution ": " enters the heart, liver, gallbladder, stomach, three burnt, large intestine the six channels." function cures mainly: heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.1. " herbal classic ": " main cold and heat, Mus flaccidity, scrofula, carbuncle malignant boil, goiter, stagnation of pathogenic heat." 2. " not Lu ": " removes tapeworm." 3. " property of medicine opinion ": " main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat." 4. " Japan hanako materia medica ": " leads to small intestinal, evacuation of pus.Control furuncle, pain relieving, logical menstruation." 5. Li Gao: " loose all menses stagnation of QI gather; Detumescence." 6. Wang Haogu: " controls deaf Hun Hun Jun Jun."

Serissa foetida: nature and flavor: light, micro-pungent, cool.Function cures mainly: dispelling wind to relieve the exterior syndrome, clearing away heat-damp and promoting diuresis, relaxing muscles and tendons and activating QI and blood in the collateral.For flu, cough, toothache, acute tonsillitis, pharyngolaryngitis, acute hepatitis, chronic hepatitis, enteritis, dysentery, infantile malnutrition, hypertension complicated headache, migraine, rheumatic arthralgia, leucorrhea; Stem ashing eye dripping controls mist.

Rhizoma Paridis: nature and flavor: bitter, cold.Slightly poisonous.Function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Epidemic encephalitis type B, stomachache, appendicitis, tuberculous lymphadenitis, tonsillitis, parotitis, mastitis, poisonous snake, insect-bite, sore swollen toxin.

Fructus Citri Sarcodactylis: nature and flavor: pungent, bitter, sour, temperature.Gui Jing: return liver, spleen, lung meridian.Function cures mainly: liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.

Ganoderma: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, liver, kidney channel.Function cures mainly: invigorating QI and tranquilization, relieving cough and asthma.For dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.

Cordyceps: nature and flavor: sweet, temperature.1. " Bencao Congxin ": " sweet, flat." 2. " property of medicine is examined ": " sweet in the mouth, warm in nature." 3. " book on Chinese herbal medicine is new again ": " is slightly poisonous.The acid of " 4. " Qinghai medical material ": " sweet in the mouth, property is put down, and gas is fragrant." return through: " book on Chinese herbal medicine is new again ": " enters lung, kidney two warp." function cures mainly: tonifying deficiency, beneficial vital essence, relieving cough and resolving phlegm.Control phlegm retention to breathe heavily and cough, dyspnea due to deficiency, consumptive disease is coughed, spitting of blood, spontaneous sweating, impotence and seminal emission, soreness of waist and knee joint, and prolonged deficiency is multiple after being ill.

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

By Semen Litchi 1 part, Semen Citri Reticulatae 1 part, Ramulus Mori 1 part, Squama Manis 0.05 part, Spica Prunellae 1 part, Rhizoma Curcumae 1 part, Rhizoma Cyperi 1 part, 1 part, Pericarpium Citri Reticulatae Viride, Bulbus Fritillariae Thunbergii 1 part, 1 part, Poria, Radix Bupleuri 1 part, Semen Vaccariae 1 part, Radix Angelicae Sinensis 0.05 part, Sanguis Draxonis 1 part, Olibanum 1 part, the Radix Paeoniae Alba 1 part, the Rhizoma Pinelliae 1 part, Radix Codonopsis 0.05 part, Caulis Spatholobi 1 part, Fructus Ligustri Lucidi 1 part, Fructus Lycii 1 part, Herba Leonuri 1 part, Rhizoma Alismatis 1 part, the Rhizoma Atractylodis Macrocephalae 1 part, 1 part, Radix Glycyrrhizae, Semen Cassiae 1 part, Fructus Trichosanthis 1 part, Herba Taraxaci 1 part, Flos Lonicerae 1 part, Cortex Acanthopancis 1 part, Radix Notoginseng 1 part, Fructus Forsythiae 1 part, Serissa foetida 1 part of crude drug is put into after pulverizer is pulverized and is crossed 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 50%, collect for subsequent use by the raw material fine powder of 100 mesh sieves, the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 3 hour, 2 extracting solution is merged and leaves standstill, in described step c, the medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 3 hour, 2 extracting solution are merged and leaves standstill, get the medicinal residues after above-mentioned ethanol extraction again, the heating and refluxing extraction that adds water 2 times.Above-mentioned two kinds of ethanol extracts are merged, when concentrating under reduced pressure relative density is 70 DEG C 1.08 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m2, and hothouse hot stream temperature is 60 DEG C, obtains raw material medicated powder; The raw material fine powder obtained after sieving and ethanol are refined medicated powder to mix and incapsulate.

Embodiment 2

By Semen Litchi 1 part, Semen Citri Reticulatae 1 part, Ramulus Mori 1 part, Squama Manis 0.05 part, Spica Prunellae 1 part, Rhizoma Curcumae 1 part, Rhizoma Cyperi 1 part, 1 part, Pericarpium Citri Reticulatae Viride, Bulbus Fritillariae Thunbergii 1 part, 1 part, Poria, Radix Bupleuri 1 part, Semen Vaccariae 1 part, Radix Angelicae Sinensis 1 part, Sanguis Draxonis 1 part, Olibanum 1 part, the Radix Paeoniae Alba 1 part, the Rhizoma Pinelliae 1 part, Radix Codonopsis 0.05 part, Caulis Spatholobi 1 part, Fructus Ligustri Lucidi 2 parts, Fructus Lycii 3 parts, Herba Leonuri 2 parts, Rhizoma Alismatis 1 part, the Rhizoma Atractylodis Macrocephalae 1 part, 3 parts, Radix Glycyrrhizae, Semen Cassiae 3 parts, Fructus Trichosanthis 1 part, Herba Taraxaci 2 parts, Flos Lonicerae 1 part, Cortex Acanthopancis 1 part, Radix Notoginseng 2 parts, Fructus Forsythiae 1 part, Serissa foetida 1 part of crude drug is put into after pulverizer is pulverized and is crossed 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 50%, collect for subsequent use by the raw material fine powder of 100 mesh sieves, the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 3 hour, 2 extracting solution is merged and leaves standstill, in described step c, the medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 3 hour, 2 extracting solution are merged and leaves standstill, get the medicinal residues after above-mentioned ethanol extraction again, the heating and refluxing extraction that adds water 2 times.Merged by above-mentioned two kinds of ethanol extracts, concentrating under reduced pressure is dried to dry cream, co-grinding, add 10% sodium chloride, cold preservation, divides and gets the supernatant, add 4 times amount beta-schardinger dextrin-s, suitable quantity of water, add cyclodextrin clathrate, starch, mix homogeneously, tabletting, then use film coating liquid, carry out coating, obtain tablet.

Embodiment 3

By Semen Litchi 1 part, Semen Citri Reticulatae 1 part, Ramulus Mori 1 part, Squama Manis 0.05 part, Spica Prunellae 1 part, Rhizoma Curcumae 1 part, Rhizoma Cyperi 1 part, 1 part, Pericarpium Citri Reticulatae Viride, Bulbus Fritillariae Thunbergii 1 part, 1 part, Poria, Radix Bupleuri 1 part, Semen Vaccariae 1 part, Radix Angelicae Sinensis 1 part, Sanguis Draxonis 1 part, Olibanum 1 part, the Radix Paeoniae Alba 1 part, the Rhizoma Pinelliae 1 part, Radix Codonopsis 0.05 part, Caulis Spatholobi 1 part, Fructus Ligustri Lucidi 2 parts, Fructus Lycii 3 parts, Herba Leonuri 2 parts, Rhizoma Alismatis 1 part, the Rhizoma Atractylodis Macrocephalae 1 part, 3 parts, Radix Glycyrrhizae, Semen Cassiae 3 parts, Fructus Trichosanthis 1 part, Herba Taraxaci 2 parts, Flos Lonicerae 1 part, Cortex Acanthopancis 1 part, Radix Notoginseng 2 parts, Fructus Forsythiae 1 part, Serissa foetida 1 part of crude drug is put into after pulverizer is pulverized and is crossed 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 50%, collect the raw material fine powder by 100 mesh sieves, fine powder after sieving is put into water soak, heat is extracted 2 times, and becoming extractum shape, is component 1, b, medicinal residues add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, and thickening filtration is extractum shape, are component 2, c, above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, and then vacuum freezing seals and get final product.

Toxicity test:

Laboratory animal

White mice is provided by Qingdao City's laboratory animal and animal experimental center.

Mice lavage administration acute toxicity testing

Application mice carries out acute toxicity testing and shows: the Traditional Chinese medicine preparation capsule agent of the present invention of Mouse oral gavage, under 387.1g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule agent of the present invention is 388.8g crude drug/kg/d (LD50 > 388.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 3888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

Rat oral gavage administration long term toxicity test

Toxicity test:

Select SD rat, give the Chinese medicine preparation tablet of the present invention of variable concentrations (16.0,5.0,1.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 160,50,10 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (16.0,5.0,1.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

Clinical.

Experiment material:

Choose the 160 routine cyclomastopathy female patients meeting following standard, at minimum 18 years old of age, maximum 58 years old, the course of disease was the shortest 2 months, the longest 1 year.Adopt the drug oral of the embodiment of the present invention 1, containing 0.5g medicated powder in every capsules, be equivalent to crude drug 2.5 grams.7 days course for the treatment of.

Diagnostic criteria

According to " Chinese medical disease Standardization of diagnosis and curative effect " (State Administration of Traditional Chinese Medicine punching cure the desease card Standardization of diagnosis and curative effect [M]. Nanjing: publishing house of Nanjing University, 1994; The diagnostic criteria of nodules of the breast 44-45.): 1. distending pain of the breast, in periodically, premenstrually to increase the weight of more than the moon, side or bilateral, and severe patient can not be touched or to the radiation of the ipsilateral axillary shoulder back of the body; 2. Breast palpation can by and lump not of uniform size, in the form of sheets, nodositas, streak, border is not obvious, pressing pain, demarcate unclear with surrounding tissue, color of the leather is constant, how the growth and decline with susceptible to anger, lump is sent out in side or bilateral, slightly reduces more than delayed menstrual cycle, axillary gland not enlargement; 3. cyclomastopathy or cystic hyperplasia of breast are all pointed out in infrared breast diagnosis instrument inspection or ultrasound diagnosis; 4. other mastopathy such as mammary gland fibroma are got rid of.

Efficacy assessment standard

Reference " up-to-date domestic and international disease treatment standard " (Chen Guiting, Xue Saiqin. up-to-date domestic and international disease treatment standard [M]. Beijing: Xueyuan Press, 1991; 807-808.) in the curative effect determinate standard of cyclomastopathy.Cure: lump disappears, mastalgia disappears, and within after drug withdrawal 3 months, does not recur.Effective: lump maximum gauge reduces more than 1/2, mastalgia disappears.Effective: lump maximum gauge reduces less than 1/2, and mastalgia alleviates; Or lump maximum gauge reduces more than 1/2, but mastalgia alleviates not obvious.Invalid: lump does not reduce or increases hardening; Or simple mastalgia is alleviated.

Result

Through treatment, in 155 routine patients, lump disappears, and mastalgia disappears, and within after drug withdrawal 3 months, does not recur, therefore meets criterion of cure.

Untoward reaction

Over the course for the treatment of tracing observation is carried out for 160 routine patients, does not find obvious untoward reaction.

The above; it is only most preferred embodiment of the present invention; not any pro forma restriction is done to the present invention; any those of ordinary skill in the art; do not departing under technical solution of the present invention ambit; utilize the method content of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, all belong to the scope of claims protection.

Claims

1. a Chinese medicine composition for prevention and therapy cyclomastopathy, is characterized in that: be made up of following component:

2. the Chinese medicine composition of a kind of prevention and therapy cyclomastopathy according to claim 1, is characterized in that: be made up of each component of following parts by weight:

3. according to the Chinese medicine composition of a kind of prevention and therapy cyclomastopathy described in claim 1 to 2, it is characterized in that: be made up of each component of following parts by weight:

4. the Chinese medicine composition of a kind of prevention and therapy cyclomastopathy according to claims 1 to 3, is characterized in that: each component composition also comprising following parts by weight: Rhizoma Paridis 1-15 part, Fructus Citri Sarcodactylis 1-15 part, Ganoderma 1-15 part, Cordyceps 1-15 part.

5. the Chinese medicine composition of a kind of prevention and therapy cyclomastopathy according to Claims 1-4, is characterized in that: the dosage form of described Chinese medicine preparation is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup.。

6., according to the preparation method of the Chinese medicine composition of a kind of prevention and therapy cyclomastopathy described in claim 1 to 5, it is characterized in that: prepared by described capsule comprises the following steps:

A. described crude drug is put into pulverizer grinding and sieving,

7. the preparation method of the Chinese medicine composition of a kind of prevention and therapy cyclomastopathy according to claim 6, it is characterized in that: in a of described step, described crude drug is put into after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 50%, collects by the raw material fine powder of 100 mesh sieves for subsequent use.

8. the preparation method of the Chinese medicine composition of a kind of prevention and therapy cyclomastopathy according to claim 6, it is characterized in that: in described step b, the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 3 hour, 2 extracting solution is merged and leaves standstill; In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 3 hour, 2 extracting solution are merged and leaves standstill.。

9. the preparation method of the Chinese medicine composition of a kind of prevention and therapy cyclomastopathy according to claim 6, it is characterized in that: in described steps d, above-mentioned two kinds of ethanol extracts are merged, when concentrating under reduced pressure relative density is 70 DEG C 1.08 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m2, hothouse hot stream temperature is 60 DEG C, obtains raw material medicated powder; The raw material fine powder obtained after sieving and ethanol are refined medicated powder to mix and incapsulate.

10. a preparation method for the prevention and therapy cyclomastopathy as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is oral solutions, and its preparation process comprises: