CN102091254B - Traditional Chinese medicine composition for relieving swelling after cosmetic surgery and preparation method thereof - Google Patents
Traditional Chinese medicine composition for relieving swelling after cosmetic surgery and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for relieving swelling after cosmetic surgery. A medicine of the composition is prepared from angelica, flower of silktree, white atractylodes rhizome, chuanxiong rhizome, teasel root, brazilwood, white peony root, rhizoma alismatis, peach kernel, milk vetch, jujube, earthworm, seed of Job's tears, rhizoma cyperi and tuckahoe; and an external medicament of the composition is prepared from red sage root, angelica sinensis, myrrh, luffa, spatholobus stem, safflower, rose mallow root, raspberry, gromwell, oldenlandia diffusa, rose, motherwort, angelica and pearl. The traditional Chinese medicine composition for relieving swelling after cosmetic surgery provided by the invention has the efficacies of promoting blood circulation, removing blood stasis, reliving pain and diminishing swelling, is convenient in administration and easy to manufacture, has low cost, and the like. In the invention, traditional Chinese medicinal materials of different properties are adopted and scientifically matched, thus achieving ideal therapeutic effects, and the traditional Chinese medicinal materials capable of promoting blood circulation, removing blood stasis, diminishing swelling, reliving pain and transporting qi and blood are selected and matched elaborately, thus regulating the flow of qi, promoting blood circulation, regulating qi and blood and dredging the channels.
Description
Technical field
The present invention relates to contain the medical preparation that derives from plant, animal or mineral component, particularly a kind ofly be used for repercussive Chinese medicine composition and preparation method thereof after the facial face-lifting.
Background technology
The raising day by day of Along with people's living standard, there has been very big change quality of life, and also beginning has gradually had higher pursuit to U.S.A.The international aesthetic medicine of the U.S. can claim that Chinese cosmetic surgery quantity occupied Asia first in 2009.And worldwide, the U.S., Brazil and China occupy first three.Along with the expansion of Chinese rich stratum and middle class's quantity, and the enhancing of celebrity's appeal, People more and more is paid attention to the appearance of oneself, and improves it teeth and nail.Simultaneously, youngster is regarded face-lifting as the stepping-stone to success of wealth and love.They want that appearance is better worked or marriage through improving.
Face-lifting originally is a good thing at first, and the chances are at first appears at after World War II, and the human organs that is used for helping war to lose organ reproduces, and finds again that afterwards this technology can help to improve people's aesthetics, just develops into a professional technique.The people that cosmetic surgery is accepted in the annual whole world is many more, has a lot of survey data to show, has correctly accepted the people of cosmetic surgery, not only can beautify, and also can on average increase life-span 3-5 year, and 7%-20% increases income.The expert thinks that clearly face-lifting can let the people strengthen confidence, experiences happyly, is of value to success, is of value to the acquisition happy life.The characteristics of social development are exactly new scientific method and the technology of constantly occurring, and people accept and enjoy these achievements, become the people in the epoch of being able to catch up with.Face-lifting not merely is to make a people's appearance become beautiful beautiful, more is once that the inspiration influence that successful shaping cosmetic surgery brings face-lifting person's psychology must not be ignored.A people's self-confidence can become more shy, the related view of improving them to the life future after strengthening.For since crowd such as the accident health unfortunate is damaged, the match campaign of congenital physiognomy defect, fierce antagonism is injured carry out plastic operation and seem important especially.Usually can make bigger promise to the health of oneself after common people's face-lifting, especially the people from high income group can alleviate mental pressure, unlikely connivance oneself excessive drinking or smoking, direct useful health.
In cosmetic surgery, facial plasty has accounted for the overwhelming majority.The augmentation rhinoplasty operation, Blepharoplasty, facelift, the ratio of mill cheek osseous surgery or the like is maximum.Face-lifting is operation after all, and risk and side effect are also deposited.And the face nerve rich, the congestion that the operation back produces, swelling is more scabrous problem in the cosmetic surgery always.Most ofly after the cosmetic surgery open anti-inflammation analgesic to the patient, analgesic antiphlogistic goes the swelling curative effect all not ideal enough, and Western medicine, the side effect of chemicals life-time service are big.What have contains a large amount of hormones; Bigger to human injury's property; What face detumescence was smeared all is some cosmetics, does not have a kind of external used medicine truly, not can solve swelling behind the operation on face, pain, problems such as congestion.Clinical a kind of cosmetic surgery rear face detumescence of being used to solve, the Chinese medicine composition of promoting blood circulation to remove blood stasis of pressing for.
Summary of the invention
Technical problem to be solved by this invention is, in prior art, is used for that repercussive oral medicine major part is the anti-inflammation analgesic of doctor trained in Western medicine entirely after the cosmetic surgery, and chemical substance is almost adopted in active ingredient entirely.Weak point is that mainly curative effect is all not ideal enough, and Western medicine, the side effect of chemicals life-time service are big, and what have contains a large amount of hormones; External used medicine is cosmetics entirely almost, does not have Chinese medicine medicine truly, not can solve problems such as swelling, pain, congestion, and a kind of repercussive Chinese medicine composition and preparation method thereof after the facial face-lifting that is used for is provided.
For solving the problems of the technologies described above, a kind of repercussive Chinese medicine composition after the facial face-lifting that is used for is provided, to form by endo-medicine and external used medicine, the ratio of weight and number of various crude drug is in the said endo-medicine: 10～20 parts of Radix Angelicae Sinensis; 10～20 parts of Flos Albiziaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Dipsacis; 10～20 parts of Lignum Sappans, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Rhizoma Alismatis, 10～20 parts in Semen Persicae; 10～20 parts of the Radixs Astragali, 10～20 parts in Fructus Jujubae, 10～20 parts of Pheretimas; 10～20 parts of Semen Coicis, 10～20 parts of Rhizoma Cyperis, 10～20 parts in Poria;
The ratio of weight and number of various crude drug is in the said external used medicine: 10～30 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Myrrhas, 10～30 parts of Retinervus Luffae Fructuss, 10～30 parts of Caulis Spatholobis, 10～30 parts on Flos Carthami, 10～30 parts of Radix Urenae Lobataes, 10～30 parts of Fructus Rubies; 10～30 parts of Radix Arnebiae (Radix Lithospermi)s, 10～30 parts of Herba Hedyotidis Diffusaes, 10～30 parts of Flos Rosae Rugosaes, 10～30 parts of Herba Leonuris, 10～30 parts of the Radixs Angelicae Dahuricae, 10～30 parts of Margaritas.
Saidly be used for repercussive Chinese medicine composition after the facial face-lifting, the ratio of weight and number of various crude drug is preferably in the endo-medicine: 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Flos Albiziaes, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes; 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Dipsacis, 10～15 parts of Lignum Sappans, 10～15 parts of the Radix Paeoniae Albas; 10～15 parts of Rhizoma Alismatis, 10～20 parts in Semen Persicae, 10～20 parts of the Radixs Astragali, 10～20 parts in Fructus Jujubae; 10～20 parts of Pheretimas, 10～20 parts of Semen Coicis, 10～20 parts of Rhizoma Cyperis, 10～20 parts in Poria;
The ratio of weight and number of various crude drug is preferably in the said external used medicine: 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Myrrhas, 10～15 parts of Retinervus Luffae Fructuss, 10～15 parts of Caulis Spatholobis, 10～15 parts on Flos Carthami, 10～15 parts of Radix Urenae Lobataes, 10～15 parts of Fructus Rubies; 10～15 parts of Radix Arnebiae (Radix Lithospermi)s, 10～15 parts of Herba Hedyotidis Diffusaes, 10～15 parts of Flos Rosae Rugosaes, 10～15 parts of Herba Leonuris, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Margaritas.
Saidly be used for repercussive Chinese medicine composition after the facial face-lifting, the ratio of weight and number of various crude drug can also be preferably in the endo-medicine: 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Albiziaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes; 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Dipsacis, 10～20 parts of Lignum Sappans, 10～20 parts of the Radix Paeoniae Albas; 10～20 parts of Rhizoma Alismatis, 10～15 parts in Semen Persicae, 10～15 parts of the Radixs Astragali, 10～15 parts in Fructus Jujubae; 10～15 parts of Pheretimas, 10～15 parts of Semen Coicis, 10～15 parts of Rhizoma Cyperis, 10～15 parts in Poria;
The ratio of weight and number of various crude drug can also be preferably in the said external used medicine: 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Myrrhas; 10～20 parts of Retinervus Luffae Fructuss, 10～20 parts of Caulis Spatholobis, 10～20 parts on Flos Carthami; 10～20 parts of Radix Urenae Lobataes, 10～20 parts of Fructus Rubies; 10～20 parts of Radix Arnebiae (Radix Lithospermi)s, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Flos Rosae Rugosaes, 10～20 parts of Herba Leonuris, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Margaritas.
For solving the problems of the technologies described above, the present invention also provides a kind of method for preparing that is used for repercussive Chinese medicine composition after the facial face-lifting, and the dosage form of said external used medicine is a face film agent; Its preparation method comprises: the crude drug of getting the said ratio of weight and number except that Margarita soaked 1-2 hour, placed multi-function extractor then, and the 5-10 that decocts amount of water for the first time and be medical material doubly; Decoct, when being heated to 100 ℃, pick up counting; After little the boiling 2 hours, emit medicinal liquid, put in the fluid reservoir from the feed opening filtration; Decoct for the second time, amount of water is that medical material 5-10 doubly measures, and is heated to 100 ℃, after little the boiling 2 hours, extracts medicinal liquid out, with the combining medicine that decocts for the first time; With merging in the back 2 times decoction liquor suction concentrating under reduced pressure jar, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, the extractum that temperature to 60 is ℃-70 ℃, cooling; Crushing pearl is added in the extractum tinning behind the ultraviolet radiation sterilizing.
For solving the problems of the technologies described above, the present invention also provides a kind of method for preparing that is used for repercussive Chinese medicine composition after the facial face-lifting, and the dosage form of said oral preparations is a capsule, and method for preparing comprises:
A. said crude drug is put into the pulverizer grinding and sieving,
B. the remaining particulate matter in back that will sieve is put into the ethanol heating and refluxing extraction 2 times;
C. get the medicinal residues behind the above-mentioned ethanol extraction again, add the water heating and refluxing extraction 2 times;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol and spray drying get medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
Among the said step a, can said crude drug be put into and cross 120 order dusting covers after pulverizer is pulverized, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching more than 30%, collects through the raw material fine powder of 120 mesh sieves subsequent use.
Among the said step b, can the remaining particulate matter in back that sieve be put into the ethanol heating and refluxing extraction 2 times of 5～10 times of amounts of weight portion, each 1～2 hour, 2 extracting solution merged leave standstill.
Among the said step c, can the medicinal residues that above-mentioned ethanol extraction is crossed be added 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging left standstill.
In the said steps d, can above-mentioned two kinds of extracting solution be merged, the concentrating under reduced pressure relative density is the filtrating of 1.38 (70 ℃); Reclaim ethanol; With gained filtrating adjustment proportion to 1.06, feed spray dryer and carry out spray drying, the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m
2, the hothouse hot stream temperature is 100 ℃, gets raw material medicated powder; The raw material fine powder that obtains after sieving mixed with raw material medicated powder incapsulate.
Saidly be used for that the endo-medicine dosage form of repercussive Chinese medicine composition medicine can be preferably after the facial face-lifting: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, suppository, plaster, cream or drop; The external used medicine dosage form can be preferably: unguentum, tincture, liniment, loose powder agent, ointment or face film agent.
Beneficial technical effects of the present invention is, compared with prior art religion, and the repercussive Chinese medicine composition had blood circulation promoting and blood stasis dispelling after the present invention was used for face-lifting, relieved the pain detumescence rapidly, convenient drug administration, advantage such as medicament is easy to make, and is with low cost.The present invention adopts the Chinese crude drug of the different property of medicine, has carried out the science compatibility, can reach ideal therapeutic effect; The present invention chooses blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, and the Chinese crude drug of operation QI and blood is arranged in pairs or groups meticulously; Through vital energy regualting and blood circulation-promoting, transfer smooth QI and blood, dredging the meridian, hold concurrently with nourishing the liver and kidney; Human body is adjusted to lastingly, stable equilibrium between yin and yang, the state that QI and blood is unobstructed.Thereby reach skin care, blood circulation promoting and blood stasis dispelling, beautify the purpose of appearance.With strong points, blood circulation promoting and blood stasis dispelling, toxin expelling heat clearing away, the detumescence of unstinging; And safety, toxic and side effects is little, and is easy to use, and healing time is short, and analgesic effect is good, can create good social and be worth and economic interests.
The specific embodiment
Chinese medicine is thought; Human body be organic whole " blood stasis " though be the pathological product of local bones and muscles injury, also can become paathogenic factor, influence the physiological function of internal organs QI and blood; QI-blood circulation is obstructed; Disorder of movement of QI is transporation of body fluid normally, causes diseases caused by retention of fluid excessive, is stranded between the skin and flesh skin and sees swelling.So " treatise on blood trouble " has saying of " blood stasis was both of a specified duration, turned to expectorant water ", " disorders of blood does not leave in water, and diseases caused by retention of the body fluid does not leave in blood ", " accumulation of blood being both of a specified duration, also can turn to water ".Therefore,, should not throw activating blood and removing stasis drug merely, and should control, just can obtain practical therapeutic effect with the method opinion of activating blood and promoting diuresis for damaging swelling.And face nerve is mostly responsive fragile, has discomfort will make the people produce uncomfortable feeling slightly.And facial cosmetic surgery metropolis causes facial swelling, and pain unbearably.The category that belongs to motherland's medical science " congestion " " muscle and tendon injury " after the operation, after the facial plasty operation, facial wound takes place, development, the process that changes and repair both had direct relation with skin and flesh muscles and bones, and again with qi-blood-body fluid, abdomen Tibetan Scripture network has inseparable relation.Operation back injures QI and blood more, hinders in the gas stagnation of QI then, hinders in blood blood clotting then, and the stagnation of QI can make hematogenous blockage and the stasis of blood stagnates, and blood clotting can block functional activity of QI being not smooth, the stagnation of QI occurs, the formation stagnation of QI-blood.Point out as far back as " element asks negative and positive big opinion ", impairment of QI resulting in pain, blood is hindered swollen, so performance silt bruise pain.Simultaneously QI and blood passes unimpeded not freely, and then body surface skin and flesh muscles and bones loses and moistens fosterly, and influence reparation is carried out.With the passing of time stagnation of QI-blood then forms subcutaneous scleroma.Therefore the relation of QI and blood and operation wound and reparation is the core pathomechanism.
So the present invention chooses blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, the Chinese crude drug of operation QI and blood is arranged in pairs or groups meticulously, through vital energy regualting and blood circulation-promoting, transfers smooth QI and blood, dredging the meridian, holds concurrently with nourishing the liver and kidney, human body is adjusted to lastingly, stable equilibrium between yin and yang, the state that QI and blood is unobstructed.Thereby reach skin care, blood circulation promoting and blood stasis dispelling, beautify the purpose of appearance.Radix Salviae Miltiorrhizae, Radix Astragali QI invigorating in the side, the hemopoietic the lucid yang sending up, Semen Persicae liver and kidney tonifying, benefit vital essence; Radix Angelicae Sinensis, Radix Paeoniae Alba replenishing blood and nourishing liver, kidney nourishing and blood enriching, Semen Coicis, Fructus Jujubae invigorating the spleen and replenishing QI YIN nourishing detumescence; Caulis Spatholobi, Radix Urenae Lobatae, Flos Campsis, the Flos Rosae Rugosae regulating menstruation and nourishing blood, activating blood circulation to dissipate blood stasis beautifies appearance; The invigorating the liver and kidney of Herba Leonuri yin nourishing blood; Rhizoma Cyperi resolving depression clearing away damp-heat; Fructus Rubi is tonified Qi of the kidney, Rhizoma Chuanxiong regulating menstruation and nourishing blood, pain relieving.Retinervus Luffae Fructus detumescence skin care; Herba Albiziae has been spent tired, arresting convulsion, the impaired reparation of the useful meridians of Radix Dipsaci.The useful taste of the Rhizoma Alismatis Rhizoma Atractylodis Macrocephalae, Poria, Lignum Sappan is dispelled to swell and invigorates blood circulation.The Margarita arresting convulsion is calmed the nerves, and the ability nourishes rough skin, repairs destructive meridians rapidly, muscles and bones.Oral medicine is made laws with treating both the principal and secondary aspects of a disease, blood circulation promoting and blood stasis dispelling, and reducing swelling and alleviating pain science compatibility, external also is intended to detumescence, and certain cosmetic result is arranged.
Radix Angelicae Sinensis, its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Rhizoma Chuanxiong is hot, temperature.Return liver, gallbladder, pericardium channel.The function blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Rhizoma Chuanxiong is warm in nature, and the ability promoting blood circulation to remove blood stasis is the good medicine that nourishes blood.
The Radix Astragali is main with tonify deficiency, ability invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and the ability enhancing body's immunological function, therefore can also be used to prevent the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " Radix Astragali is can tonifying five ZANG-organs all empty, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.
Nutritional labeling Chinese medicine theories such as Fructus Jujubae rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and calcium, phosphorus, ferrum and cyclic adenosine monophosphate are thought; Fructus Jujubae has effects such as tonify deficiency QI invigorating, nourishing blood to tranquillize the mind, invigorating the spleen and regulating the stomach, is patient's good health care nutriment fruits such as weakness of the spleen and stomach, insufficiency of vital energy and blood, lassitude, insomnia and dreamful sleep.The Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Be used for insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Regulating menstruation is invigorated blood circulation in the ability circulation of qi promoting.Be used for menoxenia, red collapsing, leucorrhea is the good merchantable brand of enriching blood.
Semen Persicae is bitter, and is sweet, puts down the special medicine that closes for blood stasis blood.Bitter to let out stagnant blood, sweet with tissue regeneration promoting blood." medicineization justice ": Semen Persicae, bitter in the mouth can rush down heat in blood, and the body profit can be grown dryness of the intestine.If gross weight grinds many usefulness, walk Liver Channel, main broken blood-retention, water month by month; And pain all over, extremity wood numbness, left hemiplegia, left sufficient patient; Relax through the promoting the circulation of blood of invigorating blood circulation with it, the merit of eliminating blood stasis to promote regeneration of blood is arranged,, go into large intestine if few usefulness is mashed in peeling; Control blood depletion and just close, the dry dyschezia of blood with its make moist removing heat from blood and blood, has relieving accumulation of pathogens to lead to stagnant power.
Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Remarkable inhibitory action is also arranged." property of medicine opinion " carried it: monarch, and sweet in the mouth, suffering, nontoxic.Can main big migratory arthralgia, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, sputum is removed in appetizing, removes cold and heat, lets out under ending.Interarea light is pleased, and preserves youthful looks, and goes to deceive.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in the abdomen is vomited and diarrhoea incessantly, and the insufficiency of stomach-QI cold-dysentery.
Radix Dipsaci, the Chinese medicine name is the root of Dipsacaceae herbaceos perennial Radix Dipsaci, because of ability " synthetism of continuous folding " is gained the name.Excavate autumn, removes root head and fibrous root, with low baking temperature baking to half-dried, when banking up " diaphoresis " to inner virescence, oven dry again." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians decide in tonifying liver, bone and muscle strengthening, end in the warp (muscles and bones) and ache, and are antiabortive, control the married woman leucorrhea, tissue regeneration promoting blood, and removing blood stasis with potent drugs blood, the stillborn fetus that falls, the cough-relieving hemoptysis of coughing is controlled red white turbid urine.”
Semen Coicis, Chinese medicine commonly used. be again generally, the food often eaten, the property slightly sweet flavor is slightly cold, and effects such as inducing diuresis to remove edema, spleen invigorating are dried, arthralgia relieving by relaxing muscles and tendons, clearing away heat and discharging pus are arranged, and is damp-clearing drug commonly used.Semen Coicis is to mend the medicinal good merchantable brand of body.According to medical department assay, Semen Coicis contains protein 16.2%, fat 4.6%, saccharide 79.2%.Be a kind of nourishing food with Semen Coicis stewed pig's feet, Os Sus domestica and chicken winter.Cooking congee with Semen Coicis summer or make cold drink ice Semen Coicis, is again the clear tonic of body-building of well relieving summer heat.The kind Renhe root of Semen Coicis can be used as medicine again and cure the disease.Li Shizhen (1518-1593 A.D.) is put down in writing in Compendium of Material Medica: Semen Coicis can " invigorating spleen and reinforcing stomach, wind prevailing over dampness be removed in the tonifying the lung heat clearing away.The food of cooking a meal is controlled cold air.Fry in shallow oil drink, the diuresis pyretic stranguria." in recent years, a large amount of scientific research and clinical practices prove that Semen Coicis still is a kind of cancer therapy drug, Preliminary Identification, and it presses down rate to controlling of cancer and can reach more than 35%." Compendium of Material Medica meaning Semen Coicis " skin care is stayed and held, makes light of one's life by commiting suicide and prolong life for invigorating spleen and reinforcing stomach, tonifying the lung heat clearing away, expelling wind and dampness ".
The Radix Paeoniae Alba goes into liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and all diseases in antenatal back, Tong Yueshui brings down a fever, relieving restlessness, QI invigorating, day hot disease of row, the pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the skin ulcer scabies, headache makes eye bright, and conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.
Rhizoma Alismatis is again one of traditional Chinese medicines.Theory of Chinese medical science thinks that it is cold in nature, has the effect of promoting diuresis to eliminate damp pathogen.Modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slow down atherosclerosis and form; Rhizoma Alismatis and preparation modern times thereof also are used to treat auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc.Rhizoma Alismatis: be longer than promoting diuresis to eliminate damp pathogen, expel the heat-evil, be used for dysuria, the edema distension, the puckery pain of stranguria with turbid discharge, seminal emission, foot knee joint flaccidity is soft; Fry Rhizoma Alismatis, be partial to and the spleen eliminating dampness by diuresis, be used for phlegm retention, dysentery, the vertigo.Rhizoma Alismatis, Poria, Polyporus; Three all can seep water dampness removing and inducing diuresis to remove edema, Chang Sanzhe is with using; Right Rhizoma Alismatis is cold in nature, can expel the heat-evil, clearly mutually fire; Poria then can heart-spleen boosting, tranquilizing mind; And Polyporus, can only the eliminating dampness by diuresis diuresis.
Poria: Poria sweet in the mouth, light, property are flat, be used as medicine have promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria ability enhancing human body immunity function, pachyman has tangible antitumor and protects the liver dirty effect.But the deficiency and coldness essence is sliding or the collapse of QI person avoids clothes.Be used for diarrhea due to hypofunction of the spleen, the leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, for have loose bowels due to the insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, use the effect that Poria has giving consideration to both the incidental and fundamental, compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Be available as the tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.
Flos Albiziae contains the Herba Albiziae glycoside, tannin, and resolving stagnation for tranquilization, the appetizing of regulating the flow of vital energy, activating collaterals to relieve pain is used for irritability, melancholy insomnia.It is uncomfortable in chest to control pent-up, and insomnia is forgetful, and acute conjunctivitis can settling five organs, and will, improving healthy complexion, have preferably keep fit, calm, the effect of calming the nerves, improve looks, also be to treat neurasthenic good merchantable brand.Also has clearing away summer-heat, face-beautifying and spot-removing effect such as relieve the effect of alcohol." book on Chinese herbal medicine warp " said: " Flos Albiziae ability settling five organs, and will, improving healthy complexion." especially to the anemia of pregnant woman, have preferably keep fit, calm, the effect of calming the nerves, improve looks, also be to treat neurasthenic good merchantable brand.
The hot little hardship of Rhizoma Cyperi is sweet, and flat function cures mainly: the resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast." detailed outline " carries it: the cold epidemic disease of the seasonal epidemic pathogens that looses, and sharp three warmers are separated six kinds of stagnation-syndromes, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot; Abdominal distention, beriberi is ended trusted subordinate, limbs, head, order, tooth, all pains of ear, and ulcer sores is spitted blood; Hematochezia, hematuria, married woman's bleeding not during menses, month time is uncomfortable, tire all kinds of diseases and ailments in preceding puerperal.
Lignum Sappan: Lignum Sappan is sweet, salty, and is flat.GUIXIN, liver, spleen channel.Function promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.Be used for the amenorrhea dysmenorrhea, postpartum stagnation, breast ventral spine pain, wound swells and ache." book on Chinese herbal medicine is looked for the truth ": Lignum Sappan, function type of having Flos Carthami, few with then can and blood, many with then can removing blood stasis.But the Flos Carthami slightly warm in nature with, then the cold nature cold is also for this.So all cause of disease the exterior and the interior wind rises, and that hyperamization stagnates is not all right, and the puerperal blood faints distension is dead with (desires), and blood pain abdominal mass due to blood stasis, through diseases such as the heap soil or fertilizer over and around the roots of holding one's breath, carbuncle, injury from falling down, all should phase disease close and recuperate under medical treatment with his medicine.
Pheretima: Compendium of Material Medica is referred to as to have dredge the meridian passage, blood circulation promoting and blood stasis dispelling, the effect of prophylactic treatment cardiovascular and cerebrovascular disease.Pheretima is cold in nature distinguishes the flavor of.Function: heat clearing away, suppressing the hyperactive liver, Zhichuan, logical Lip river.It is fanatical dry to cure mainly height, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, hemiplegia etc.Pheretima provides gets liquid the good effect that cloperastine is breathed heavily of deciding is arranged.
The external herbal pharmacology:
Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to invigorate blood circulation latus rectum, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy goes into the blood chamber, and delirium is gone mad; Or vexed interior the expanding of blood, the sudden syncope with rigidity is that all puerperal, non-Flos Carthami can not be decided at card as extremely.All friendship like the obstructed and cold and heat of amenorrhea done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollen burst uneasyly, is cards of disharmony between QI and blood all, and non-Flos Carthami can not be transferred.
Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.. " detailed outline " carries: Radix Salviae Miltiorrhizae, by " the sensible opinion of married woman " cloud, SIWU TANG is controlled the gynecopathy, pays no attention to antenatal puerperal, through water what, all can be general, only flavor Radix Salviae Miltiorrhizae looses, and cures mainly identical with it.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.
Radix Arnebiae (Radix Lithospermi) is cold in nature, sweet in the mouth, salty.GUIXIN, Liver Channel.Function cures mainly removing heat from blood, invigorates blood circulation the detoxifcation rash.Be used for that heat in blood poison is contained, purple black, the measles without adequate eruption of macule, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood is used for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention.
Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carry it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; The women has through uncomfortable; Dysmenorrhea.Be the good medicine of invigorating blood circulation.
Herba Hedyotidis Diffusae is Herba Hedyotidis Diffusae, two leaves, Herba Commelinae Bengalensis, Chinese Lobelia again.Mildly bitter flavor, sweet, cold.Go into stomach, large intestine, small intestine meridian, the clearing up internal heat by using drugs of bitter in taste and cold in nature detoxifcation, sweet cold eliminating damp-heat has stronger removing toxicity for eliminating carbuncles effect to carbuncle, pharyngalgia, snakebite etc.Generally be used to treat sore, laryngopharynx swelling and pain, abdominalgia with intestinal abscess, venom, also be used for the puckery pain of pyretic stranguria, dysuria.Be the good medicine of damp eliminating of drawing out pus by applying a plaster to the affected part.
The Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, dispel silt, regulating menstruation, water disappears.The treatment menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, rushes down blood, the carbuncle skin infection at hematuria.Herba Leonuri contains materials such as leonurine, Fumaric acid, and effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema are arranged.
Fructus Rubi is warm in nature; Sweet, sour; Return kidney, urinary bladder channel.Cure mainly: kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.Be used for enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea." Bencao Jingshu ": " Fructus Rubi, its main QI invigorating person says beneficial vital essence also.Kidney storing essence, kidney improving inspiration by invigorating kidney-QI, vital essence is sufficient, and then body is sent out not in vain not also from light.The respectful main tonify deficiency of reviving is continuous exhausted, reinforcing YIN-essence Jianyang, smoothing skin, peace and internal organs.Zhen Quan master man kidney-jing deficiency exhausts, impotence, woman's food son arranged.Big bright main settling five organs, beneficial color is supported vital essence, long hair, strong will.All get its kidney tonifying and add essence, the adopted ear of sweet acid convergence." " property of medicine opinion " carry its: " main man's kidney-jing deficiency exhausts, woman's food son arranged.Main impotence.″
Flos Rosae Rugosae sweet in the mouth, little hardship, gas is fragrant.Warm in nature.Go into liver, stomach warp.Supplementary Amplifications of the Compendium of Materia Medica carries: " gas perfume (or spice) is warm in nature, and sweet and slightly bitter taste is gone into spleen, Liver Channel, regulating and activating blood circulation." " property of medicine is examined " cloud: " Flos Rosae Rugosae is warm in nature, the promoting the circulation of blood removing mass." " book on Chinese herbal medicine is new again " meaning: " the strongly fragrant gas of soothing liver-QI gallbladder, spleen invigorating pathogenic fire reducing." so the hot fragrant row of Flos Rosae Rugosae looses the effect of performance promoting QI circulation for relieving depression and blood dissipating blood stasis speckle removing.
Radix Urenae Lobatae property is sweet, and is light, puts down into the heart, lung meridian.The effect expelling wind and removing dampness, heat-clearing and toxic substances removing.Cure mainly cold, fever, rheumatic arthralgia, dysentery, edema, leucorrhea is spitted blood, carbuncle, traumatic hemorrhage, venom, acute infantile convulsion, tetanus, asthma, stomachache puerperal exposure to wind." Luchuan book on Chinese herbal medicine " carries: removing mass, poison looses.Control traumatic injury, carbuncle sore is the good medicine of treatment gynecological.
The Myrrha blood blood stasis removing that looses, subduing swelling and relieving pain.Control traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Hardship, suffering, flat.1. " property of medicine opinion ": " bitter in the mouth is hot." 2. " Haiyao Bencao, Oversea Materia Medica ": " bitter in the mouth is hot, and temperature is nontoxic." 3. " Kaibao Bencao ": " and bitter in the mouth, flat, nontoxic." go into liver, spleen, the heart, kidney channel.1. " Bencao Jingshu ": " go into meridian of Foot-JUE YIN." 2. " book on Chinese herbal medicine is newly organized ": " go into spleen, kidney two warps." 3. " book on Chinese herbal medicine is looked for the truth ": " go into the heart, liver." join Olibanum, promoting blood circulation to remove blood stasis, circulation of qi promoting Shujin; Wear Squama Manis, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.Match exhausts, promoting blood circulation to remove blood stasis, pain relieving.Join Realgar, detumescence and promoting granulation, dampness detoxifcation.
The Radix Angelicae Dahuricae: meridian distribution of property and flavor: suffering, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.Be used for wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.It is overworked to be used for headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin scabies."Japan Hanako Materia Medica": governance red eyes and pterygium, and fill Tailou fall, broken blood places, make new blood, milk carbuncle, hair back, scrofula, intestinal wind, hemorrhoids fistula, abscess, wound, scabies, myogenic pain, to face Shao-defect scar.
Margarita: Margarita has effects such as the arresting convulsion of calming the nerves, the nebula that makes eye bright, removing toxic substances and promoting granulation, and modern study shows that also Margarita all has unique effect at aspects such as improving body immunity, slow down aging, freckle removing and whitening, supplement calcium.The arresting convulsion of calming the nerves, the heat clearing away YIN nourishing makes eye bright, detoxifcation.1. relieving palpitation arresting convulsion is applicable to palpitation with fear palpitation with a distress feeling, epilepsy infantile convulsion.2. liver heat removing makes eye bright except that nebula, with controlling ophthalmic diseasess such as conjunctival congestion and swelling pain, pterygium, many externals.3. convergence granulation promoting is applicable to that throat rots, aphtha of the mouth and tongue, ulcer do not close up suitable external for a long time." book on Chinese herbal medicine converges and says ": relieving palpitation, decide will, the peace soul, the poison that unhitches is changed malignant boil, receives the internal ulceration junk.
Retinervus Luffae Fructus: dredge the meridian passage is arranged, the effect of removing toxic substances and promoting subsidence of swelling.Cure mainly pain in chest and hypochondrium; Rheumatic arthralgia, passages through which vital energy circulates contracture, galactostasis, lung gesture cough, carbuncle future sore, his carbuncle." book on Chinese herbal medicine is just read ": Retinervus Luffae Fructus, go into meridians, separate pathogenic heat.Evanescence of heat then wind goes, and the unlikely combination of body fluid in the network and be expectorant becomes all diseases of toxic swelling, the ear so cloud detoxifies.
It is that the sweet method for preparing of refining pill of agent comprises that the present invention is used for facial plasty repercussive oral medicine: get Radix Angelicae Sinensis 1000g, Flos Albiziae 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Rhizoma Chuanxiong 1000g; Radix Dipsaci 1000g, Lignum Sappan 1000g, Radix Paeoniae Alba 1000g, Rhizoma Alismatis 1000g; Semen Persicae 1000g, Radix Astragali 1000g, Fructus Jujubae 1000g, Pheretima 1000g; Semen Coicis 1000g, Rhizoma Cyperi 1000g, Poria 1000g;
The raw medicinal material of getting above-mentioned ratio of weight and number soaked 1 hour, placed multi-function extractor then, decocted amount of water for the first time and be 10 times of medical material; Decoct, when being heated to 100 ℃, pick up counting; After little the boiling 2 hours, emit medicinal liquid, put in the fluid reservoir from the feed opening filtration; Decoct for the second time, amount of water is 10 times of amounts of medical material, is heated to 100 ℃, after little the boiling 2 hours, extracts medicinal liquid out, with the combining medicine that decocts for the first time; With merging in the back 2 times decoction liquor suction concentrating under reduced pressure jar, be decompressed to 0.03-0.08MPa, temperature remains on 75 ℃, and being concentrated into relative density is 1.20, the extractum of temperature to 65 ℃; Put into baking oven, be controlled at 75 ℃, dry postcooling, mixing with Mel is twisted into slice, the wax seal packing.
The method for preparing of capsule comprises: with said crude drug Radix Angelicae Sinensis 1500g, Flos Albiziae 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Rhizoma Chuanxiong 1500g, Radix Dipsaci 1500g; Lignum Sappan 1500g, Radix Paeoniae Alba 1500g, Rhizoma Alismatis 1500g, Semen Persicae 1500g; Radix Astragali 1500g, Fructus Jujubae 1500g, Pheretima 1500g, Semen Coicis 1500g; Rhizoma Cyperi 1500g, Poria 1500g puts into and crosses 120 order dusting covers after pulverizer is pulverized, and the fine powder amount that enable pass is crossed 120 mesh sieves is reaching more than 30%; Collect through the raw material fine powder of 120 mesh sieves subsequent usely, the remaining particulate matter in back that sieves is put into the ethanol heating and refluxing extraction 2 times of 5～10 times of amounts of weight portion, each 1～2 hour, 2 extracting solution are merged leave standstill; The medicinal residues that above-mentioned ethanol extraction is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging are left standstill; Above-mentioned two kinds of extracting solution are merged, and the concentrating under reduced pressure relative density is the filtrating of 1.38 (70 ℃), reclaims ethanol, with gained filtrating adjustment proportion to 1.06, feeds spray dryer and carries out spray drying, and the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m
2, the hothouse hot stream temperature is 100 ℃, gets raw material medicated powder; The raw material fine powder that obtains after sieving mixed with raw material medicated powder incapsulate.
The method for preparing of external-use tincture comprises:
Radix Salviae Miltiorrhizae 200g, Radix Angelicae Sinensis 200g, Myrrha 200g, Retinervus Luffae Fructus 200g, Caulis Spatholobi 200g, Flos Carthami 200g, Radix Urenae Lobatae 200g, Fructus Rubi 200g; Radix Arnebiae (Radix Lithospermi) 200g, Herba Hedyotidis Diffusae 200g, Flos Rosae Rugosae 200g, Herba Leonuri 200g, Radix Angelicae Dahuricae 200g, Margarita 200g.
Said component is mixed by proportioning, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle after fine powder sieves; At normal temperatures and pressures, flooded 10～20 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter; Get filtrating after the separation, mixed with aforementioned concentrated solution then.External-use tincture, but smear every day.
The preparation of external face film agent may further comprise the steps: get Radix Salviae Miltiorrhizae 200g, Radix Angelicae Sinensis 200g, Myrrha 200g, Retinervus Luffae Fructus 200g, Caulis Spatholobi 200g, Flos Carthami 200g, Radix Urenae Lobatae 200g, Fructus Rubi 200g; Radix Arnebiae (Radix Lithospermi) 200g, Herba Hedyotidis Diffusae 200g, Flos Rosae Rugosae 200g, Herba Leonuri 200g; Radix Angelicae Dahuricae 200g soaked 1-2 hour, placed multi-function extractor then, and the 5-10 that decocts amount of water for the first time and be medical material doubly; Decoct, when being heated to 100 ℃, pick up counting; After little the boiling 2 hours, emit medicinal liquid, put in the fluid reservoir from the feed opening filtration; Decoct for the second time, amount of water is that medical material 5-10 doubly measures, and is heated to 100 ℃, after little the boiling 2 hours, extracts medicinal liquid out, with the combining medicine that decocts for the first time; With merging in the back 2 times decoction liquor suction concentrating under reduced pressure jar, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, the extractum that temperature to 60 is ℃-70 ℃, cooling; Margarita 200g is pulverized in the adding extractum tinning behind the ultraviolet radiation sterilizing.Can directly be applied in face during use and spend the night, wipe the next morning and get final product.
The method for preparing that unguentum is smeared in external may further comprise the steps:
Get Radix Salviae Miltiorrhizae 500g, Radix Angelicae Sinensis 500g, Myrrha 500g, Retinervus Luffae Fructus 500g, Caulis Spatholobi 500g, Flos Carthami 500g, Radix Urenae Lobatae 500g, Fructus Rubi 500g; Radix Arnebiae (Radix Lithospermi) 500g, Herba Hedyotidis Diffusae 500g, Flos Rosae Rugosae 500g, Herba Leonuri 500g; Radix Angelicae Dahuricae 500g mixes by proportioning, drops into pulverizer and is ground into fine powder, puts into the acid and alkali-resistance infusion kettle after fine powder sieves, at normal temperatures; Flooded 20 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrating after the separation, and the heating of will filtrating is concentrated into pasty state; Put into the oven for drying postcooling, 500g grinds to form fine powder with Margarita, adds vaseline and reconciles into pasty state.Can directly smear the affected part.
Pharmacology's toxicity test
1. skin irritation test
Get rabbit and shave hair, induce and excite contact test with external used medicine face film agent of the present invention, viewing test rabbit after 24 hours and 48 hours, all loseing skin has phenomenons such as erythema and edema, with the negative control group zero difference.The result shows that this face film agent is bordering on zero to dermoreaction intensity, does not promptly have skin allergic reaction, and clinical practice is safe and reliable.Acute skin irritation test: these article are according to 6.3 joints in Ministry of Public Health " cosmetics health standard " (2002) second portions " skin irritation/corrosion test "; Male 4 of Japan large ear rabbit, body weight 2kg～3kg gets these article 0.5g and directly spreads upon on the skin of animal left side (opposite side is as contrast); Adopt blocking test; 4 hours application time, after the off-test with the residual thing that tried of warm water washing, in remove tried thing after 1h, 24h, 48h and 72h observe respectively that animal is tried to distinguish and the dermoreaction of check plot; The top average is " 0 ", judges that the article of being somebody's turn to do are to the animal skin nonirritant.
2. long term toxicity test
Select the SD rat for use; Give variable concentrations (18.0,6.0, the capsule of the Chinese medicine composition of the present invention of 2.0g crude drug/kg), irritate stomach every day once, continuous 90 days; Respectively organized 1/2 animal (male and female half and half) extremely that lives in 24 hours after the last administration, all the other 1/2 animals continuation observation, 2 all backs are extremely alive.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, after the administration 90 days with carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) in 2 weeks of drug withdrawal and check with indexs such as blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology.Result of the test shows: Chinese medicinal composition capsules agent of the present invention is good at high, medium and low dose groups animal general state, all no abnormal variation of outward appearance sign, behavioral activity, food-intake and body weight gain; Three dose groups and matched group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range, do not have significant difference between group; Each is organized the main organs histopathological examination and is not seen obviously unusual.The These parameters drug withdrawal is not seen change after 2 weeks yet.This test dosage is respectively 180,60,20 times of clinical medicine dose; According to result of the test Chinese medicinal composition capsules agent of the present invention high, medium and low three dosage (18.0,6.0, the 2.0g crude drug/kg) administration in continuous 90 days does not have obvious influence to rat; No clear and definite toxicity target organ and sensitive indicator; The retardance toxic reaction is not seen in the convalescent period observation yet, points out the dosage safety property of Chinese medicine composition clinical practice of the present invention higher.
The endo-medicine pharmacodynamic experiment
Animal: the used mice of experimental example is the Kunming kind, is provided by Shandong Medical University's biology laboratory.
Model is built group: blank group, oral pills of the present invention, capsule; The external face film agent; The YUNNAN BAIYAO group, the aspirin group.
1, function of promoting blood circulation to disperse blood clots
(1), to the influence of clotting time of mice and plasma fibrinogen content
The result of clotting time of mice sees table 1.With the blank group relatively, the clotting time of pill of the present invention 800,1600mg/kg dose groups mice obviously prolongs (P＜0.01).Compare with the YUNNAN BAIYAO group, clotting time does not have significant difference (P＜0.05).
The result of mice plasma fibrinogen content sees table 2.Compare with the blank group, pill 1600mg/kg dosage of the present invention has utmost point appreciable impact (P＜0.01) to the mice plasma fibrinogen content, and other each dose groups does not all have obvious influence (P＞0.05).
Table 1, to the influence of clotting time of mice (X ± SD)
| Group | Number of animals (only) | Clotting time (second) |
| The blank group | 10 | 253.0±146.1 |
| YUNNAN BAIYAO (300mg/kg) | 10 | 241.1±147.6 |
| Pill of the present invention (400mg/kg) | 10 | 296.5±240.9 |
| Pill of the present invention (800mg/kg) | 10 | 336.7±161.4 |
| Pill of the present invention (1600mg/kg) | 10 | 386.4±247.3 |
Compare with the blank group,
*P＜0.05;
*P＜0.01;
Table 2, to the influence of mice plasma fibrinogen content (X ± SD)
| Group | Number of animals (only) | Fibrinogen content (mg/dl) |
| The blank group | 10 | 134.7±21.0 |
| YUNNAN BAIYAO (300mg/kg) | 10 | 139.1±30.0 |
| Pill of the present invention (400mg/kg) | 10 | 128.6±28.7 |
| Pill of the present invention (800mg/kg) | 10 | 142.9±25.2 |
| Pill of the present invention (1600mg/kg) | 10 | 176.7±59.0 * |
Compare with the blank group,
*P=0.05;
*P＜0.01
(2), to the thrombotic influence of rat arteriovenous shut
Rat suppository weight result sees table 3.With the blank group relatively, the thrombus weight of capsule of the present invention 800,1600mg/kg dose groups rat all significantly alleviates (P＜0.05 or＜0.01).Other test group does not then have obvious influence (P＞0.05).Capsule of the present invention and YUNNAN BAIYAO group compare, no difference of science of statistics (P＞0.05).
Table 3, the influence (X ± SD) that rat suppository is formed
| Group | Number of animals (only) | Wet weight of thrombus (mg) |
| The blank group | 10 | 26.0±5.9 |
| YUNNAN BAIYAO (300mg/kg) | 10 | 18.2±7.5 * |
| Capsule of the present invention (400mg/kg) | 10 | 24.3±4.3 |
| Capsule of the present invention (800mg/kg) | 10 | 17.3±3.7 ** |
| Capsule of the present invention (1600mg/kg) | 10 | 16.7±5.1w ** |
Compare with the blank group,
*P＜0.05,
*P＜0.01
2, analgesic activity
(1), mice hot plate method experiment
Mouse writhing number of times result sees table 4.Compare with the blank group; Each dose groups of capsule of the present invention all has prolongation trend at the changing value of the mice pain threshold of each minute; But do not have significant difference (P＞0.05), show between capsule of the present invention and the aspirin dose group and compare that the changing value of pain threshold is no significant difference also.
Table 4, to the influence of mice pain threshold (X ± SD)
Compare P＞0.05 with the blank group
(2), mouse writhing experiment
Mouse writhing number of times result sees table 5.Compare with the blank group, reaction all has obvious suppression effect (P＜0.01) to each dose groups of capsule of the present invention to mouse writhing.Through variance analysis, capsule 400mg/kg dose groups of the present invention and aspirin compare with dose groups, and turning round the body number of times has significant difference (P＜0.05), show that the painful effect in capsule of the present invention town is better than aspirin.
Table 5, to the influence of mouse writhing number of times (X ± SD)
| Group | Number of animals (only) | Turn round the body number of times | Suppression ratio (%) |
| The blank group | 10 | 53.7±16.8 | |
| Aspirin (200mg/kg) | 10 | 23.0±13.5 ** | 61.5 |
| Capsule of the present invention (400mg/kg) | 10 | 33.5±13.8 ** | 37.6 |
| Capsule of the present invention (800mg/kg) | 10 | 20.3±8.2 ** | 56.6 |
| Capsule of the present invention (1600mg/kg) | 10 | 18.3±8.8 ** | 62.2 |
Compare with blank,
*P＜0.01; Compare P＜0.01 with capsule 400mg/kg group of the present invention
Administration time is seen table 6 to the result that influences of mouse writhing number of times.Compare with the blank group, the body time number average of turning round of each administration group mice has significant difference (P＜0.01).Measured in 1 hour after the administration, the body suppression ratio of turning round of capsule 800mg/kg group only of the present invention reaches 50% (being judged as the standard with analgesic activity); Measured the turning round the body suppression ratio and all can reach more than 50% of each administration group mice after the administration in 2 hours.The result shows that capsule onset effect of the present invention is faster than aspirin.
Table 6, administration time are to the influence of mouse writhing number of times (X ± SD)
| Group | Number of animals (only) | Turn round the body number of times | Suppression ratio (%) |
| The blank group | 10 | 41.9±13.9 | |
| Aspirin (200mg/kg) | 10 | 10.3±9.1 ** | 75.4 |
| Capsule of the present invention (400mg/kg) | 10 | 25.4±8.1 ** | 39.4 |
| Capsule of the present invention (800mg/kg) | 10 | 26.0±8.0 ** | 37.9 |
| Capsule of the present invention (1600mg/kg) | 10 | 23.1±10.0 ** | 44.9 |
Compare with blank,
*P＜0.01
3, antiinflammatory action
(1), to the influence of mouse peritoneal capillary permeability
The OD value result of mouse peritoneal liquid sees table 6.With the blank group relatively, the OD value that each medication is 10 groups all descends to some extent, pill of the present invention 400,1600mg/kg dose groups have significant difference (P＜0.05).Through variance analysis, the onset dosage of pill of the present invention is 400mg/kg, and the suppression ratio of three dosage of pill of the present invention all is higher than the aspirin of corresponding dosage, shows that pill effect of the present invention is better than aspirin.
Table 7, to the influence of mouse peritoneal capillary permeability (X ± SD)
Compare with blank,
*P＜0.05,
*P＜0.01
(2), Oleum Tiglii is caused the inhibitory action of mice auricle swelling
Face film agent of the present invention is applied in Oleum Tiglii causes on the mice auricle swelling model group, matched group is smeared YUNNAN BAIYAO.Swelling degree and suppression ratio result see table 8.With the blank group relatively, face film agent of the present invention 800,1600mg/kg dose groups all have the inhibitory action (P＜0.05) of significance to the mice auricle swelling that is caused by Oleum Tiglii.Through variance analysis, each dose groups of face film agent of the present invention and YUNNAN BAIYAO is corresponding relatively, there was no significant difference, but suppression ratio is higher than the YUNNAN BAIYAO agent.
Table 8, Oleum Tiglii caused the inhibitory action (X ± SD) of mice auricle swelling
| Group | Number of animals (only) | The swelling degree | Suppression ratio (%) |
| The blank group | 10 | 9.83±3.59 | |
| YUNNAN BAIYAO group (200mg/kg) | 10 | 5.33±2.53 ** | 45.8 |
| Face film agent of the present invention (100mg/kg) | 10 | 7.75±4.45 | 21.1 |
| Face film agent of the present invention (200mg/kg) | 10 | 5.83±1.85 * | 42.5 |
| Face film agent of the present invention (300mg/kg) | 10 | 5.08±1.60 ** | 38.1 |
Compare with blank,
*P＜0.05,
*P＜0.01.
Clinical data:
My institute since two thousand seven uses Chinese medicine and accelerates the process that the postoperative local swelling is disappeared, and treats and follow up a case by regular visits to patient's 32 examples altogether, and respond well, report as follows.
1 clinical data
This organizes 96 examples, augmentation rhinoplasty 72 examples wherein, and grand lower jaw art 14 examples, mill cheek bone 10 examples are divided into three groups at random.A organizes male 4 examples in 32 examples, women 28 examples, 18～48 years old age, average 26 years old; B organizes 32 examples and is the women, 19～49 years old age, average 24 years old; C organizes male 5 examples in 32 examples, women 27 examples, 18～45 years old age, average 26 years old.
2 Therapeutic Method
All cases are all in out-patient treatment, and augmentation rhinoplasty all adopts the silicone rubber nasal mould type, the nasal vestibule otch; Grand jaw art also adopts silicone rubber model, intra-oral approach; Mill cheek bone is intra-oral approach.1 week of postoperative oral antibiotic.The A group, postoperative promptly begins to take from intending Chinese medicine decoction of the present invention, divides and takes for 3 times 1 dose of every day, obeys 6 days altogether, and smears facial film of the present invention every night, and wipe the next morning.The B group, postoperative is promptly taken the each 10mg of Seradase sheet, 3 times on the 1st, obeys altogether 6 days.The C group, postoperative is not taken other medicines except that antibiotic.
3 therapeutic outcomes
Be as the criterion 3.1 observe when criterion of therapeutical effect was taken out stitches with postoperative on the 6th day.Apart from patient 1m is point of observation.Obviously swelling: there is swelling nose and related part near the eyes thereof behind the augmentation rhinoplasty; The local visible obviously swelling of grand jaw postoperative, the swelling of mill cheek bone art whole face severe; Mild swelling: behind the augmentation rhinoplasty only the nasion portion swelling is arranged, do not have ecchymosis near the eyes.Grand jaw postoperative local swelling is not obvious, the swelling of mill cheek bone art whole face moderate.No swelling: can not observe the part has swelling, mill cheek bone art whole face mild swelling.
3.2 observed result is seen table 1,2.
3 groups of therapeutic effect comparative examples of table 1
| Group | n | Obviously swelling | Mild swelling | No swelling |
| A | 32 | 3 | 10 | 19 |
| B | 32 | 5 | 11 | 16 |
| C | 32 | 7 | 18 | 7 |
Through sum of ranks inspection, Hc (gauged H-number)=8.87, P＜0.05
Comparing in twos of three groups of therapeutic effect of table 2
| Relatively | ?a | S | q | q0.05 | P |
| A group and B group | ?2 | 105.325 | 1.67 | 2.77 | |
| B group and C group | ?2 | 104.127 | 3.97 | 2.61 | ＜0.05 |
| A group and C group | ?3 | 157.582 | 3.77 | 3.31 | ＜0.05 |
4 discuss
The Seradase sheet reaches company by Tai Wanwei and produces; Contain Serrapeptase; The vascular permeability that wound is caused is hyperfunction to have inhibitory action, can reduce local inflammation and ooze out, to fibrin, the original powerful dissolution of fibrin; Can promote cellulose dissolution, eliminating in the blood capillary, be used for nose, oral mucosa swelling has obvious regressive effect.
The present invention has the effect of soothing the liver circulation of qi promoting, and Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba have the merit of promoting blood circulation to remove blood stasis; In addition the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Alismatis invigorating spleen to remove dampness are to promote detumescence.In clinical; We go up plus-minus and use in the basis up, and with observations of making comparisons of Seradase sheet and another matched group, the C that confirms to subside a swelling the present invention effect obviously is superior to contrasting organizes (P＜0.05); On the detumescence curative effect, there is not significant difference (P＞0.05) with clothes Seradase group; But B group patient has 5 examples stomach discomfort, nauseating phenomenon to occur in drug administration process, and wherein 1 example is because of the serious drug withdrawal of symptom, and A group patient does not have 1 example and untoward reaction occurs.
Embodiment 1: the Wang, and the woman, 24 years old, accepted augmentation rhinoplasty operation in my institute in July, 2008, adopts the silicone rubber nasal mould type, the nasal vestibule otch, there is swelling nose and related part near the eyes thereof behind the augmentation rhinoplasty.Postoperative is taken capsule of the present invention, oral medicinal herb prescription: Radix Angelicae Sinensis 15g, Flos Albiziae 10g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Chuanxiong 15g, Radix Dipsaci 10g, Lignum Sappan 10g, Radix Paeoniae Alba 15g, Rhizoma Alismatis 10g, Semen Persicae 15g, Radix Astragali 10g, Fructus Jujubae 10g, Pheretima 15g, Semen Coicis 10g, Rhizoma Cyperi 10g, Poria 10g; External prescription: Radix Salviae Miltiorrhizae 15g, Radix Angelicae Sinensis 10g, Myrrha 10g, Retinervus Luffae Fructus 15g, Caulis Spatholobi 15g, Flos Carthami 10g, Radix Urenae Lobatae 15g, Fructus Rubi 10g; Radix Arnebiae (Radix Lithospermi) 10g, Herba Hedyotidis Diffusae 15g, Flos Rosae Rugosae 15g, Herba Leonuri 15g, Radix Angelicae Dahuricae 10g, Margarita 10g.Take for oral administration the branch sooner or later for 2 times.Face film agent is processed in external.Begin to smear every night after tearing gauze open, morning flush away.Treat detumescence in 7 days.Patient introduces good analgesic effect.
Embodiment 2: Lee, and the man, 25 years old, went to a doctor in May, 2009, accepts grand jaw art in my institute, the local visible obviously swelling in back.Postoperative is taken pill of the present invention, oral medicinal herb prescription: Radix Angelicae Sinensis 15g, Flos Albiziae 10g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Chuanxiong 15g, Radix Dipsaci 15g, Lignum Sappan 10g, Radix Paeoniae Alba 15g, Rhizoma Alismatis 10g, Semen Persicae 15g, Radix Astragali 15g, Fructus Jujubae 10g, Pheretima 15g, Semen Coicis 10g, Rhizoma Cyperi 15g, Poria 10g; External prescription: Radix Salviae Miltiorrhizae 15g, Radix Angelicae Sinensis 15g, Myrrha 10g, Retinervus Luffae Fructus 15g, Caulis Spatholobi 15g, Flos Carthami 10g, Radix Urenae Lobatae 15g, Fructus Rubi 10g; Radix Arnebiae (Radix Lithospermi) 15g, Herba Hedyotidis Diffusae 10g, Flos Rosae Rugosae 10g, Herba Leonuri 15g, Radix Angelicae Dahuricae 10g, Margarita 10g.Take for oral administration the branch sooner or later for 2 times.Face film agent is processed in external.Begin to smear every night after tearing gauze open, morning flush away.Treat recovery from illness after 10 days.Patient introduces good analgesic effect, and detumescence rapidly.
Embodiment 3: gold certain, the woman, 33 years old, consultation time in February, 2008 threw and examines.Come my institute's full-face to draw the skin operation of compacting, the facial mild swelling of postoperative, oral medicinal herb prescription: Radix Angelicae Sinensis 15g, Flos Albiziae 10g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Chuanxiong 15g; Radix Dipsaci 15g, Lignum Sappan 10g, Radix Paeoniae Alba 15g, Rhizoma Alismatis 10g, Semen Persicae 15g, Radix Astragali 15g; Fructus Jujubae 10g, Pheretima 15g, Semen Coicis 10g, Rhizoma Cyperi 10g, Poria 15g; External prescription: Radix Salviae Miltiorrhizae 15g, Radix Angelicae Sinensis 15g, Myrrha 10g, Retinervus Luffae Fructus 15g, Caulis Spatholobi 15g, Flos Carthami 10g, Radix Urenae Lobatae 15g, Fructus Rubi 10g; Radix Arnebiae (Radix Lithospermi) 15g, Herba Hedyotidis Diffusae 10g, Flos Rosae Rugosae 10g, Herba Leonuri 15g, Radix Angelicae Dahuricae 10g, Margarita 10g.Take for oral administration the branch sooner or later for 2 times.Face film agent is processed in external.Begin to smear every night after tearing gauze open, morning flush away.Treat recovery from illness after 15 days.Patient introduces good analgesic effect, and detumescence rapidly.
Embodiment 4: Feng, and the woman, 28 years old, consultation time in February, 2009 throwing was examined.Come the comprehensive double eyelid plasty of my institute, postoperative eye mild swelling has pain, and is depressed.Oral medicinal herb prescription: Radix Angelicae Sinensis 15g, Flos Albiziae 10g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Chuanxiong 15g, Radix Dipsaci 15g, Lignum Sappan 10g, Radix Paeoniae Alba 15g, Rhizoma Alismatis 10g, Semen Persicae 15g, Radix Astragali 15g, Fructus Jujubae 10g, Pheretima 15g, Semen Coicis 10g, Rhizoma Cyperi 15g, Poria 10g; External prescription: Radix Salviae Miltiorrhizae 15g, Radix Angelicae Sinensis 15g, Myrrha 10g, Retinervus Luffae Fructus 15g, Caulis Spatholobi 15g, Flos Carthami 10g, Radix Urenae Lobatae 15g, Fructus Rubi 10g; Radix Arnebiae (Radix Lithospermi) 15g, Herba Hedyotidis Diffusae 10g, Flos Rosae Rugosae 10g, Herba Leonuri 15g, Radix Angelicae Dahuricae 10g, Margarita 10g.Take for oral administration the branch sooner or later for 2 times.Face film agent is processed in external.Tear behind the gauze beginning open and smear eye every night, morning flush away.Treat recovery from illness after 7 days.Patient introduces good analgesic effect, and detumescence is rapid, and mood improves.
Claims (9)
1. one kind is used for repercussive Chinese medicine composition after the facial face-lifting, it is characterized in that be made up of endo-medicine and external used medicine, the ratio of weight and number of various crude drug is in the said endo-medicine: 10～20 parts of Radix Angelicae Sinensis; 10～20 parts of Flos Albiziaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Dipsacis; 10～20 parts of Lignum Sappans, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Rhizoma Alismatis, 10～20 parts in Semen Persicae; 10～20 parts of the Radixs Astragali, 10～20 parts in Fructus Jujubae, 10～20 parts of Pheretimas; 10～20 parts of Semen Coicis, 10～20 parts of Rhizoma Cyperis, 10～20 parts in Poria;
The ratio of weight and number of various crude drug is in the said external used medicine: 10～30 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Myrrhas, 10～30 parts of Retinervus Luffae Fructuss; 10～30 parts of Caulis Spatholobis, 10～30 parts on Flos Carthami, 10～30 parts of Radix Urenae Lobataes, 10～30 parts of Fructus Rubies; 10～30 parts of Radix Arnebiae (Radix Lithospermi)s, 10～30 parts of Herba Hedyotidis Diffusaes, 10～30 parts of Flos Rosae Rugosaes; 10～30 parts of Herba Leonuris, 10～30 parts of the Radixs Angelicae Dahuricae, 10～30 parts of Margaritas.
2. be used for repercussive Chinese medicine composition after the facial face-lifting according to claim 1 is said, it is characterized in that the ratio of weight and number of various crude drug is in the said endo-medicine: 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Flos Albiziaes, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes; 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Dipsacis, 10～15 parts of Lignum Sappans, 10～15 parts of the Radix Paeoniae Albas; 10～15 parts of Rhizoma Alismatis, 10～20 parts in Semen Persicae, 10～20 parts of the Radixs Astragali, 10～20 parts in Fructus Jujubae; 10～20 parts of Pheretimas, 10～20 parts of Semen Coicis, 10～20 parts of Rhizoma Cyperis, 10～20 parts in Poria;
The ratio of weight and number of various crude drug is in the said external used medicine: 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Myrrhas, 10～15 parts of Retinervus Luffae Fructuss; 10～15 parts of Caulis Spatholobis, 10～15 parts on Flos Carthami, 10～15 parts of Radix Urenae Lobataes, 10～15 parts of Fructus Rubies; 10～15 parts of Radix Arnebiae (Radix Lithospermi)s, 10～15 parts of Herba Hedyotidis Diffusaes, 10～15 parts of Flos Rosae Rugosaes; 10～15 parts of Herba Leonuris, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Margaritas.
3. be used for repercussive Chinese medicine composition after the facial face-lifting according to claim 1 is said, it is characterized in that the ratio of weight and number of various crude drug is in the said endo-medicine: 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Albiziaes, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes; 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Dipsacis, 10～20 parts of Lignum Sappans, 10～20 parts of the Radix Paeoniae Albas; 10～20 parts of Rhizoma Alismatis, 10～15 parts in Semen Persicae, 10～15 parts of the Radixs Astragali, 10～15 parts in Fructus Jujubae; 10～15 parts of Pheretimas, 10～15 parts of Semen Coicis, 10～15 parts of Rhizoma Cyperis, 10～15 parts in Poria;
The ratio of weight and number of various crude drug is 10～20 parts of Radix Salviae Miltiorrhizaes in the said external used medicine, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Myrrhas, 10～20 parts of Retinervus Luffae Fructuss; 10～20 parts of Caulis Spatholobis, 10～20 parts on Flos Carthami, 10～20 parts of Radix Urenae Lobataes, 10～20 parts of Fructus Rubies; 10～20 parts of Radix Arnebiae (Radix Lithospermi)s, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Flos Rosae Rugosaes; 10～20 parts of Herba Leonuris, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Margaritas.
4. one kind like each said method for preparing that is used for repercussive Chinese medicine composition after the facial face-lifting in the claim 1～3, it is characterized in that the dosage form of said external used medicine is a face film agent; Its preparation method comprises: the crude drug of getting the said ratio of weight and number except that Margarita soaked 1-2 hour, placed multi-function extractor then, and the 5-10 that decocts amount of water for the first time and be crude drug doubly; Decoct; When being heated to 100 ℃, pick up counting, after little the boiling 2 hours; Emit medicinal liquid from the feed opening filtration, put in the fluid reservoir; Decoct for the second time, amount of water is that crude drug 5-10 doubly measures, and is heated to 100 ℃, after little the boiling 2 hours, extracts medicinal liquid out, with the combining medicine that decocts for the first time; With merging in the back 2 times decoction liquor suction concentrating under reduced pressure jar, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, the extractum that temperature to 60 is ℃-70 ℃, cooling; Crushing pearl is added in the extractum tinning behind the ultraviolet radiation sterilizing.
5. one kind like each said method for preparing that is used for repercussive Chinese medicine composition after the facial face-lifting in the claim 1～3, it is characterized in that the dosage form of said endo-medicine is a capsule, and its preparation method comprises:
A. said crude drug is put into the pulverizer grinding and sieving;
B. the remaining particulate matter in back that will sieve is put into the ethanol heating and refluxing extraction 2 times;
C. get the medicinal residues behind the above-mentioned ethanol extraction again, add the water heating and refluxing extraction 2 times;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol and spray drying get medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
6. method for preparing according to claim 5; It is characterized in that, among the said step a, said crude drug is put into pulverizer pulverizing back cross 120 order dusting covers; The fine powder amount that enable pass is crossed 120 mesh sieves reaches more than 30%, collects through the raw material fine powder of 120 mesh sieves subsequent use.
7. method for preparing according to claim 5 is characterized in that, among the said step b, the remaining particulate matter in back that sieves is put into the ethanol heating and refluxing extraction 2 times of 5～10 times of amounts of weight portion, each 1～2 hour, 2 extracting solution is merged leave standstill.
8. method for preparing according to claim 5 is characterized in that, among the said step c, the medicinal residues that above-mentioned ethanol extraction is crossed add the water heating and refluxing extraction 2 times of 5～10 times of amounts of weight portion, each 1～2 hour, 2 extracting solution is merged leave standstill.
9. method for preparing according to claim 5; It is characterized in that in the said steps d above-mentioned two kinds of extracting solution are merged, relative density is 1.38 filtrating when being evaporated to 70 ℃; Reclaim ethanol; With gained filtrating adjustment proportion to 1.06, feed spray dryer and carry out spray drying, the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m
2, the hothouse hot stream temperature is 100 ℃, gets raw material medicated powder; The raw material fine powder that obtains after sieving mixed with raw material medicated powder incapsulate.
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| CN1279090A (en) * | 1999-06-25 | 2001-01-10 | 刘永香 | Powdered medicine for conditioning viscera and whole body |
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| CN101757598A (en) * | 2009-11-05 | 2010-06-30 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating advanced malignant liver tumor symptoms and preparation method thereof |
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