CN103417836B - Chinese medicine composition for the treatment of tumor and preparation method thereof - Google Patents
Chinese medicine composition for the treatment of tumor and preparation method thereof Download PDFInfo
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Abstract
The invention discloses Chinese medicine composition for the treatment of tumor and preparation method thereof.Including: Rhizoma Polygonati 20 40 parts, Caulis Spatholobi 20 40 parts, Herb Gynostemmae Pentaphylli 20 40 parts, Herba Agrimoniae 20 40 parts, Herba Bidentis Bipinnatae 15 35 parts, Herba Diclipterae Chinensis 15 35 parts, Radix Morindae Officinalis 15 35 parts, Semen Vaccariae 15 35 parts, Radix Dipsaci 8 20 parts, 8 20 parts of Fructus Mori and 2 10 parts of Radix Glycyrrhizae.Chinese medicine composition of the present invention can be prepared as the most acceptable oral drug preparation of any one according to Chinese medicine conventional formulation method.Chinese medicine composition of the present invention has blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, resolving phlegm and softening hard masses, effect of dampness dampness removing, and clinical efficacy shows that Chinese medicine composition of the present invention is definitely reliable for tumor efficiency, treating both the principal and secondary aspects of a disease, and clinical practice safety is without any side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition treating tumor and system thereof
Preparation Method, belongs to the treatment by Chinese herbs field of tumor.
Background technology
Tumor is a kind of commonly encountered diseases, frequently-occurring disease, and wherein malignant tumor is that harm human health is the most serious at present
One class disease.Tumor be body under various tumorigenesis factor effects, the cell of local organization is on gene level
Lose the normal regulation that it is grown, cause paraplasm and the neoplasm that formed.This neoplasm is referred to as
Tumor.The cause of disease of tumor is classified as endogenous cause of ill and exopathogenic factor.Some condition of internal body or situation are suitable for external environment
The effect of middle carcinogen, these crowds have just possessed the endogenous cause of ill of pathogenesis of cancer, including Nervous and Mental Factors, interior point
Secrete imbalance, immunodeficiency and inherited genetic factors etc..The cancer of about 80%～90% is caused by environmental factors,
Extraneous carcinogenic factor is the important stimulus factor causing cancer, it is known that carcinogenic extraneous factor have chemistry, physics,
Biology, nutrition etc. are several, including smoking and passive smoking, occupational factor, lonizing radiation and ultraviolet, the mankind
Dietary structure all relevant with the cause of disease of cancer with custom, medicine etc..According to domestic statistics, China is newly sent out
Cancer patient reaches 1,200,000 people, dies from this disease person and reaches 900,000 people, the most every 40 seconds dead people.Therefore,
Prevent and treat an important subject and urgent task that malignant tumor has become as in world-wide medical field.
The traditional Chinese medical science thinks the life of cancer, must travel precancerous lesion, and why forms precancerous lesion, is then many
Plant the result of combined factors effect.At the internal organs virtual loss that damaged by excess of seven emotions or other factors cause, disorder of QI and blood etc.
In the case of interior-deficiency, carcinogenic factor (physics, chemistry, biological) exopathogen is as the condition changed, logical
Cross interior-deficiency, cause morbidity.Inside and outside combined pathogens, causes human body qi depression to blood stasis, expectorant solidifying poison knot, forms tumor.
Be presently used for treating Chinese patent medicine the also existing the most in various degree of tumor take effect slow, curative effect is the most notable
Etc. defect, have much room for improvement.
Summary of the invention
The technical problem to be solved is to overcome existing slow, the treatment that takes effect of existing treatment tumor
The defects such as effect is notable not, toxic and side effects is big, it is provided that a kind of instant effect, determined curative effect, have no side effect
The Chinese medicine composition for the treatment of tumor；
Another technical problem to be solved by this invention is to provide a kind of side preparing above-mentioned Chinese medicine composition
Method.
Above-mentioned technical problem to be solved by this invention is achieved through the following technical solutions:
A kind of Chinese medicine composition treating tumor, each component including following weight portion forms: Rhizoma Polygonati, Sanguis Gallus domesticus
Rattan, Herb Gynostemmae Pentaphylli, Herba Agrimoniae, Herba Bidentis Bipinnatae, Herba Diclipterae Chinensis, Radix Morindae Officinalis, Semen Vaccariae, Radix Dipsaci, Fructus Mori, sweet
Grass.
Preferably, the weight portion of each component is: Rhizoma Polygonati 20-40 part, Caulis Spatholobi 20-40 part, Herb Gynostemmae Pentaphylli 20-40
Part, Herba Agrimoniae 20-40 part, Herba Bidentis Bipinnatae 15-35 part, Herba Diclipterae Chinensis 15-35 part, Radix Morindae Officinalis 15-35 part,
Semen Vaccariae 15-35 part, Radix Dipsaci 8-20 part, Fructus Mori 8-20 part, Radix Glycyrrhizae 2-10 part.
More selecting, the weight portion of each component is: Rhizoma Polygonati 20-30 part, Caulis Spatholobi 20-30 part, Herb Gynostemmae Pentaphylli 20-30
Part, Herba Agrimoniae 20-30 part, Herba Bidentis Bipinnatae 15-25 part, Herba Diclipterae Chinensis 15-25 part, Radix Morindae Officinalis 15-25 part,
Semen Vaccariae 15-25 part, Radix Dipsaci 8-15 part, Fructus Mori 8-15 part, Radix Glycyrrhizae 2-6 part.
Most preferably, the weight portion of each component is: Rhizoma Polygonati 25 parts, Caulis Spatholobi 25 parts, Herb Gynostemmae Pentaphylli 25 parts,
Herba Agrimoniae 25 parts, Herba Bidentis Bipinnatae 18 parts, Herba Diclipterae Chinensis 18 parts, Radix Morindae Officinalis 18 parts, Semen Vaccariae 18 parts, continuous
Disconnected 10 parts, Fructus Mori 10,4 parts of Radix Glycyrrhizae.
Rhizoma Polygonati: different name Rhizoma Polygonati, Caput Gallus domesticus are joined.For liliaceous plant Rhizoma Polygonati, P. cyrtonema, hot river Rhizoma Polygonati,
P. kingianum, the rhizome of polygonatum cirrhifolium Royle.Nature and flavor: sweet are flat.Return spleen, lung, kidney channel.Function cures mainly: invigorating middle warmer
QI invigorating, moistens cardiopulmonary, bone and muscle strengthening.Controlling deficient cold and heat, pulmonary tuberculosis hemoptysis, after being ill body void lack of appetite, muscles and bones is weak,
Rheumatalgia, wind favus disease.
Caulis Spatholobi: different name Radix seu Caulis Verntilaginis Leiocarpae.For leguminous plant spatholobus suberectus, Mucuna birdwoodiana, fragrant flower Moghania fluminalis(C. B. Clarke) Li rattan or bright
The rattan of leaf Moghania fluminalis(C. B. Clarke) Li rattan.Nature and flavor: bitter sweet, temperature.GUIXIN, spleen channel.Function cures mainly: invigorate blood circulation, relaxing muscles and tendons.Control waist
Knee joint soreness, paralysis and numbness, menoxenia.
Herb Gynostemmae Pentaphylli: different name Herba Gynostemmatis, Herb Gynostemmae Pentaphylli, Herba Gynostemmatis.Herb for cucurbitaceous plant Herb Gynostemmae Pentaphylli.
Nature and flavor: bitter in the mouth, cold in nature, nontoxic.Function cures mainly: eliminating inflammation and expelling toxin, and eliminating phlegm and stopping cough controls chronic bronchitis.
Herba Agrimoniae: different name Agrimony, execute state Agrimony, melon Rhizoma et radix valerianae, HUANGLONG tail, ferrum wasp, goldentop dragon,
Old stork mouth, primary and secondary grass, dry foot mattress etc..Herb for rosaceous plant Radix Agrimoniae.Nature and flavor: toil are flat.
Return lung, liver, spleen channel.Function cures mainly: hemostasis, stomach invigorating.Control spitting of blood, spit blood, hematuria, have blood in stool, red in vain
Dysentery, bleeding not during menses, impairment caused by overstrain takes off power, carbuncle, traumatic injury, wound hemorrhage.
Herba Bidentis Bipinnatae: different name ghost hairpin Hemerocallis citrina Baroni careless, terrible, Shandong lao-ya-tsao, Herba Bidentis Bipinnatae, ghost spicule, Herba Bidentis Bipinnatae,
Look into the distance Staphasagria, Rhizoma Homalomenae, family's Herba silenes fortunei etc..Herb for feverfew Herba Bidentis Bipinnatae.Nature and flavor: 1. bitter in the mouth, flat,
Nontoxic (supplement to the Herbal).The most warm in nature, bitter in the mouth, nontoxic (" Quanzhou book on Chinese herbal medicine ").Function cures mainly: heat clearing away,
Removing toxic substances, dissipating blood stasis, detumescence.Treating malaria disease, diarrhoea, dysentery, hepatitis, acute nephritis, stomachache, dysphagic, intestinal
Carbuncle, laryngopharynx swelling and pain, traumatic injury, snake bite and insect sting.
Herba Diclipterae Chinensis: different name gold dragon rod, Hepar Sus domestica dish, blue or green Serpentis, Herba Diclipterae Chinensis, wheat head Serpentis red, blue or green are young, wild peppery
Green pepper, Hepar Caprae seu ovis dish, soil Saigae Tataricae, false rice pin, Herba Lobeliae taliensis, false red indigo plant, wild blue or green young, Justicia procumbens linn..For Acanthaceae
The herb of plant Herba Diclipterae Chinensis.Nature and flavor: bitter, cold.Function cures mainly: heat clearing away, removing heat from blood, diuresis, removing toxic substances.Control
Calentura macule, has blood in stool, hematuria, dysuria, toxic swelling furuncle.
Radix Morindae Officinalis: different name bar halberd, Radix Morindae Officinalis, rabbit intestinal.Root for Maguireothamnus speciosus Radix Morindae Officinalis.Nature and flavor:
Xin Gan, tepor.Return liver, kidney channel.Function cures mainly: kidney-replenishing, wind-damp dispelling, strengthening bone and muscle.Control sexual impotence, few
Abdomen cold type of pain, incontinence of urine, deficiency-cold of uterus, anemofrigid-damp arthralgia, soreness of the waist and knees.
Semen Vaccariae: different name is not stayed row, taboo palace flower, cut JINHUA, Herba Clematidis Huchouensis grass, Mai Lanzi, gold small cup silver
Platform.Seed for pinkwort Vaccaria segetalis.Nature and flavor: bitter are flat.Return liver, stomach warp.Function cures mainly: OK
Blood stimulates the menstrual flow, expedites the emergence of stimulating milk secretion, detumescence sore.Control women's amenorrhea, galactostasis, difficult labour, stranguria with blood, carbuncle gold
Skin ulcer is hemorrhage.
Radix Dipsaci: different name dragon bean, genus folding, synthetism, south grass, Rhizoma seu Herba Elatostematis stewardii, Radix Dipsaci.For Chuan Duan section plant river
Radix Dipsaci or the root of Radix Dipsaci.Nature and flavor: toil, tepor.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, continuous muscle
Bone, blood circulation regulating.Control aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, pass out semen, traumatic injury,
Incised wound, anal fistula, carbuncle skin ulcer swells.
Fructus Mori: different name Mulberry reality, black mulberry, Fructus Mori, Sang Shi, crow mulberry, civil and military real, Mulberry Fructus Jujubae, Sang Li,
Mulberry etc..Fruit ear for moraceae plants Mulberry.Nature and flavor: sweet, cold.Return Liver Channel, kidney channel.Function cures mainly: mend
Liver, kidney tonifying, cease phoenix, grow liquid.Controlling hepatic and renal YIN deficiency, quench one's thirst, constipation, mesh is dark, tinnitus, articular instability etc..
Radix Glycyrrhizae: different name Glycyrrhizae, close grass sweet, close, state are old, Radix Glycyrrhizae, Herba Hedyotis cantonensis, sweet root, rod are careless, clever
Lead to.Root and rhizome for glycyrrhizic legume.Nature and flavor: sweet are flat.Return spleen, stomach, lung meridian.Function master
Control: and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Moxibustion use, controls weakness of the spleen and stomach, lack of appetite, loose stool of suffering from abdominal pain,
Overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus etc.；Raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, solve
Poison of drug and alimentary toxicosis.
Chinese medicine composition of the present invention is to the pathogenetic research of deep layer of tumor and treatment thereof based on inventor
Principle, simultaneously according to inventor's clinical experience for many years and pharmaceutical research achievement, filters out blood circulation promoting and blood stasis dispelling, clearly
Thermal detoxification, resolving phlegm and softening hard masses, the crude drug of dampness dampness removing, form according to certain weight proportion prescription.
There is when adding the raw material of following weight portion in above-mentioned Chinese medicine composition more preferable blood circulation promoting and blood stasis dispelling, clear
Effect of thermal detoxification: Herba Verbenae 5-10 part, Radix Angelicae Sinensis 5-10 part, Radix Paeoniae Rubra 4-8 part, Spina Gleditsiae 4-8 part,
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 4-8 part；Preferably, the weight portion of each raw material is: Herba Verbenae 8 parts, Radix Angelicae Sinensis 8 parts, Radix Paeoniae Rubra 6
Part, Spina Gleditsiae 6 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 6 parts.
Herba Verbenae: different name wind neck grass, purple top dragon bud, Herba lespedezae pilosae, Bermuda grass, the arthroncus of knee, practice hard grass,
Deng.Nature and flavor: bitter are cool.Return liver, spleen channel.Function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation to restore menstrual flow, inducing diuresis to remove edema.
Control fever caused by exogenous pathogens, jaundice due to damp-heat, edema, dysentery, diphtheria, amenorrhea, malaria, sore throat, carbuncle sore tumefacting virus,
Ulcerative gingivitis etc..
Radix Angelicae Sinensis: different name is dry returns.Nature and flavor: sweet, acrid, warm.Return liver, the heart, spleen channel.Function cures mainly: enrich blood
And blood, menstruction regulating and pain relieving, moisturize laxation.Controlling menoxenia, amenorrhea is suffered from abdominal pain, and lump in the abdomen knot is poly-, metrorrhagia, blood deficiency
Headache, dizziness, flaccidity syndrome and arthralgia syndrome；Dryness of the intestine dyschezia, weight after bloody dysentery；Ulcer sores, injury from falling down.
Radix Paeoniae Rubra: different name wood Radix Paeoniae, red Radix Paeoniae, Radix Paeoniae Rubra, Radix clerodendri bungei.For ranunculaceae plant Radix Paeoniae,
The root of Paeonia obovata Maxim., river Radix Paeoniae Rubra etc..Nature and flavor: bitter are cool.Return liver, spleen channel.Function cures mainly: clots absorbing, only
Bitterly, removing heat from blood, detumescence.Controlling the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, and stomachache, hypochondriac pain, epistaxis, dysentery, under hemorrhoidal hamorrhage
Blood, conjunctival congestion, carbuncle.
Spina Gleditsiae: different name Fructus Gleditsia acupuncture, Spina Gleditsiae, sky fourth, SPINA GLEDITSIAE, soap pin.For leguminous plant Fructus Gleditsia
Spina jujubae.Nature and flavor: pungent, temperature.Gui Jing: lung meridian, Liver Channel.Concocting method: pick decontamination, is soaked in water,
Cut into slices after running through, dry.Function cures mainly: search wind, draws out pus by applying a plaster to the affected part, detumescence, evacuation of pus.Control carbuncle, sore, tinea
Skin ulcer, placenta retention, leprosy.
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae): nature and flavor: bitter, cool.Mild toxicity.Gui Jing: GUIXIN warp, Liver Channel, lung meridian, stomach through, big
Intestinal warp.Function cures mainly: anticancer, the reducing swelling and alleviating pain of relieving internal heat, heat clearing away arresting convulsion, antitussive and antiasthmatic.Control carbuncle pulmonary tuberculosis long
Cough, the disease such as traumatic injury, snake bite and insect sting, lymphoid tuberculosis, osteomyelitis.
Have when drug composition adds the raw material of following weight portion in the present invention further and preferably reduce phlegm
Eliminating stagnation, effect of dampness dampness removing: Pseudobulbus cremastrae seu pleiones 5-12 part, Radix Adenophorae 5-12 part, Semen Coicis 4-10 part, flat
Bean 3-8 part, Cortex Magnoliae Officinalis 3-8 part；Preferably, the weight portion of each raw material is: Pseudobulbus cremastrae seu pleiones 9 parts, Radix Adenophorae 9
Part, Semen Coicis 7 parts, 5 parts of Seem Lablab Album, Cortex Magnoliae Officinalis 5 parts.
Pseudobulbus cremastrae seu pleiones: different name gold lamp, Herba pyrolae japonicae, Pseudobulb of Appendiculate Cremastra, Pseudobulbus Cremastrae seu Pleiones, aunt Zhu, Rodgersia podophylla A. Gray, Mao aunt,
PSEUDOBULBUS CREMASTRAE APPENDICULATAE, mud ice, place aunt, Bai Dili, Bai Maogu.Vacation for orchid Cremastra appendiculata, pleione bulbocodioides etc.
Bulb.5～dig duty soccer fraud stem June；Remove stem and leaf, fibrous root, clean, dry.Nature and flavor: Gan Weixin, cold.
Return liver, spleen channel.Function cures mainly: detumescence, eliminating stagnation, reduces phlegm, removing toxic substances.Control carbuncle furuncle to swell, scrofula, sore throat
Swell and ache, Serpentis, worm, mad dog wound.
Radix Adenophorae: different name Radix Adenophorae (Radix Glehniae), BAIPAO ginseng, Radix Talini Paniculati etc..For Campanulaceae adenophora tetraphylla or other
The root of several congeners.Nature and flavor: sweet micro-hardship are cool.Return lung meridian, Liver Channel.Function cures mainly: nourishing YIN and clearing away lung-heat,
Expelling phlegm for arresting cough.Controlling lung-heat type cough, chronic consumptive disease chronic cough, the moon hinders dry pharynx laryngalgia
Semen Coicis: for the kernel of grass Semen Coicis.China's most area is all produced, main product Fujian,
Hebei, Liaoning.Property slightly sweet flavor, cool.Return spleen channel, lung meridian, kidney channel.Cure mainly spleen invigorating, tonifying the lung, heat clearing away,
The effect of dampness removing.Cure mainly and have loose bowels, arthralgia chiefly caused by damp pathogen, muscle arteries and veins contracture, joint stuffiness, edema, tinea pedis, consumptive lung disease, lung
Carbuncle, acute appendicitis, stranguria with turbid discharge, leucorrhea etc..
Seem Lablab Album: the white seed of leguminous plant Seem Lablab Album.Nature and flavor are sweet, flat.Return spleen channel, stomach warp.Spleen invigorating and
In, removing dampness of relieving summer heat.There are the effects such as invigorating the spleen for eliminating dampness, inducing diuresis to remove edema, liver heat removing and eyesight improving.
Cortex Magnoliae Officinalis: different name pachydermia, pipe, magnolia hypoleuca, strong Piao.For Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils.
It is dried dried bark, root bark and branch skin.Nature and flavor: toil, temperature.Return spleen, stomach, large intestine channel.Function cures mainly: temperature
In, the therapeutic method to keep the adverse QI flowing downwards, dampness, expectorant.Controlling chest and abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappears, and phlegm retention is breathed with cough,
Cold-damp dysentery.
The blood circulation promoting and blood stasis dispelling that in side of the present invention, each medicine compatibility is played the most altogether, heat-clearing and toxic substances removing, resolving phlegm and softening hard masses, dry
Effect of wet dampness removing, Chinese medicine composition of the present invention controls for tumor specimen is double, and clinical observation on the therapeutic effect confirms, this
Invention Chinese medicine composition is definitely reliable for tumor efficiency, true.Chinese medicine composition of the present invention is nontoxic,
Safe and reliable, have no adverse reaction after taking, Clinical practice safety.
Each taste crude drug used by the present invention can be commercially available at pharmacy.
Medicine activity component of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrate
Agent, lubricant, adhesive etc., be prepared as any suitable clinical mouth with conventional method of Chinese medicinal
Formulation, described oral formulations can be pill, powder, granule, capsule, tablet, oral liquid,
Drop pill etc..
A kind of preparation method of Chinese medicine composition of the present invention: each crude drug of the present invention is joined by described weight portion
After weighing, pulverize, sieve (can be such as 100-300 mesh sieve), to obtain final product.It is of course also possible to will be each
After crude drug is pulverized, add the adjuvant needed for preparations shaping or excipient, be conventionally prepared as capsule
Agent, tablet or pill.
The another kind of preparation method of Chinese medicine composition of the present invention: weigh each crude drug by described weight portion；Will be each
Crude drug soak by water, merges decoction liquor, filters, and filtrate is condensed into clear paste, adds the adjuvant of preparations shaping
Or excipient, preparations shaping, to obtain final product.
The usage of Chinese medicine composition of the present invention and consumption: the dosage of the present invention depends on concrete dosage form, patient
Age, the factor such as health status.As guidance: usage and dosage: capsule, each capsule content 0.3
Gram crude drug, the most oral 1 to 3,3 times on the one, 10 days be a course for the treatment of.
Detailed description of the invention
Further describing the present invention below in conjunction with specific embodiment, these embodiments are only exemplary, this
Skilled person it should be understood that can be to skill of the present invention under without departing from the spirit and scope of the present invention
The details of art scheme and form are modified or replace, but these amendments and replacement each fall within the protection of the present invention
In the range of.
The preparation of embodiment 1 capsule
Weigh each crude drug (unit: g) by following weight: Rhizoma Polygonati 20, Caulis Spatholobi 20, Herb Gynostemmae Pentaphylli 20,
Herba Agrimoniae 20, Herba Bidentis Bipinnatae 15, Herba Diclipterae Chinensis 15, Radix Morindae Officinalis 15, Semen Vaccariae 15, Radix Dipsaci 8, Fructus Mori 8,
Radix Glycyrrhizae 2；By above-mentioned each crude drug boiling secondary, add water 4 times of weight for the first time, decocts 2 hours, the
Secondary adds water 5 times of weight, decocts 1.5 hours；Decoction liquor being merged, filter, filtrate is concentrated into the closeest
Degree is the clear paste of 1.17-1.19 (60 DEG C)；Merge twice clear paste, add appropriate amount of starch, mixing, dry, powder
Broken, add appropriate amount of ethanol and make granule, be dried, granulate, fill capsule, to obtain final product.
The preparation of embodiment 2 capsule
Each crude drug (unit: g) is weighed: Rhizoma Polygonati 40, Caulis Spatholobi 40, Herb Gynostemmae Pentaphylli 40, celestial by following weight
Crane grass 40, Herba Bidentis Bipinnatae 35, Herba Diclipterae Chinensis 35, Radix Morindae Officinalis 35, Semen Vaccariae 35, Radix Dipsaci 20, Fructus Mori 20,
Radix Glycyrrhizae 10；By above-mentioned each crude drug boiling secondary, add water 6 times of weight for the first time, decocts 2 hours,
Add water 4 times of weight for the second time, decocts 1.5 hours；Decoction liquor being merged, filter, filtrate is concentrated into relatively
Density is the clear paste of 1.17-1.19 (60 DEG C)；Merge twice clear paste, add appropriate amount of starch, mixing, be dried,
Pulverize, add appropriate amount of ethanol and make granule, be dried, granulate, fill capsule, to obtain final product.
The preparation of embodiment 3 capsule
Weigh each crude drug (unit: g) by following weight: Rhizoma Polygonati 25, Caulis Spatholobi 25, Herb Gynostemmae Pentaphylli 25,
Herba Agrimoniae 25, Herba Bidentis Bipinnatae 18, Herba Diclipterae Chinensis 18, Radix Morindae Officinalis 18, Semen Vaccariae 18, Radix Dipsaci 10, Fructus Mori 10,
Radix Glycyrrhizae 4；By above-mentioned each crude drug boiling secondary, add water 4 times of weight for the first time, decocts 2 hours, the
Secondary adds water 5 times of weight, decocts 1.5 hours；Decoction liquor being merged, filter, filtrate is concentrated into the closeest
Degree is the clear paste of 1.30-1.35 (55 DEG C)；Merge twice clear paste, add appropriate amount of starch, mixing, dry, powder
Broken, add appropriate amount of ethanol and make granule, be dried, granulate, fill capsule, to obtain final product.
The preparation of embodiment 4 capsule
Each crude drug (unit: g) is weighed: Rhizoma Polygonati 20, Caulis Spatholobi 20, Herb Gynostemmae Pentaphylli 20, celestial by following weight
Crane grass 20, Herba Bidentis Bipinnatae 15, Herba Diclipterae Chinensis 15, Radix Morindae Officinalis 15, Semen Vaccariae 15, Radix Dipsaci 8, Fructus Mori 8, sweet
Grass 2, Herba Verbenae 5, Radix Angelicae Sinensis 5, Radix Paeoniae Rubra 4, Spina Gleditsiae 4, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 4；Above-mentioned each crude drug is added water
Decocting secondary, add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5
Hour；Decoction liquor being merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 DEG C)；
Merge twice clear paste, add appropriate amount of starch, mixing, it is dried, pulverizes, adds appropriate amount of ethanol and make granule, be dried,
Granulate, fills capsule, to obtain final product.
The preparation of embodiment 5 capsule
Weigh each crude drug (unit: g) by following weight: Rhizoma Polygonati 40, Caulis Spatholobi 40, Herb Gynostemmae Pentaphylli 40,
Herba Agrimoniae 40, Herba Bidentis Bipinnatae 35, Herba Diclipterae Chinensis 35, Radix Morindae Officinalis 35, Semen Vaccariae 35, Radix Dipsaci 20, Fructus Mori 20,
Radix Glycyrrhizae 10, Herba Verbenae 10, Radix Angelicae Sinensis 10, Radix Paeoniae Rubra 8, Spina Gleditsiae 8, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 8；By above-mentioned each raw material
Medicine boiling secondary, add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time,
Decoct 1.5 hours；Decoction liquor being merged, filter, it is 1.17-1.19 (60 DEG C) that filtrate is concentrated into relative density
Clear paste；Merge twice clear paste, add appropriate amount of starch, mixing, it is dried, pulverizes, adds appropriate amount of ethanol and make
Grain, is dried, granulate, fills capsule, to obtain final product.
The preparation of embodiment 6 capsule
Weigh each crude drug (unit: g) by following weight: Rhizoma Polygonati 25, Caulis Spatholobi 25, Herb Gynostemmae Pentaphylli 25,
Herba Agrimoniae 25, Herba Bidentis Bipinnatae 18, Herba Diclipterae Chinensis 18, Radix Morindae Officinalis 18, Semen Vaccariae 18, Radix Dipsaci 10, Fructus Mori 10,
Radix Glycyrrhizae 4, Herba Verbenae 8, Radix Angelicae Sinensis 8, Radix Paeoniae Rubra 6, Spina Gleditsiae 6, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 6；Above-mentioned each crude drug is added
Soak by water secondary, add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts
1.5 hour；Decoction liquor being merged, filter, it is 1.17-1.19 (60 DEG C) that filtrate is concentrated into relative density
Clear paste；Merge twice clear paste, add appropriate amount of starch, mixing, it is dried, pulverizes, adds appropriate amount of ethanol and make
Grain, is dried, granulate, fills capsule, to obtain final product.
The preparation of embodiment 7 capsule
Weigh each crude drug (unit: g) by following weight: Rhizoma Polygonati 20, Caulis Spatholobi 20, Herb Gynostemmae Pentaphylli 20,
Herba Agrimoniae 20, Herba Bidentis Bipinnatae 15, Herba Diclipterae Chinensis 15, Radix Morindae Officinalis 15, Semen Vaccariae 15, Radix Dipsaci 8, Fructus Mori 8,
Radix Glycyrrhizae 2, Pseudobulbus cremastrae seu pleiones 5, Radix Adenophorae 5, Semen Coicis 4, Seem Lablab Album 3, Cortex Magnoliae Officinalis 3；Above-mentioned each crude drug is added water
Decocting secondary, add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5
Hour；Decoction liquor being merged, filter, it is the clear of 1.17-1.19 (60 DEG C) that filtrate is concentrated into relative density
Cream；Merge twice clear paste, add appropriate amount of starch, mixing, it is dried, pulverizes, adds appropriate amount of ethanol and make granule,
It is dried, granulate, fills capsule, to obtain final product.
The preparation of embodiment 8 capsule
Weigh each crude drug (unit: g) by following weight: Rhizoma Polygonati 40, Caulis Spatholobi 40, Herb Gynostemmae Pentaphylli 40,
Herba Agrimoniae 40, Herba Bidentis Bipinnatae 35, Herba Diclipterae Chinensis 35, Radix Morindae Officinalis 35, Semen Vaccariae 35, Radix Dipsaci 20, Fructus Mori 20,
Radix Glycyrrhizae 10, Pseudobulbus cremastrae seu pleiones 12, Radix Adenophorae 12, Semen Coicis 10, Seem Lablab Album 8, Cortex Magnoliae Officinalis 8；By above-mentioned each crude drug
Boiling secondary, add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts
Boil 1.5 hours；Decoction liquor being merged, filter, it is 1.17-1.19 (60 DEG C) that filtrate is concentrated into relative density
Clear paste；Merge twice clear paste, add appropriate amount of starch, mixing, it is dried, pulverizes, adds appropriate amount of ethanol and make
Grain, is dried, granulate, fills capsule, to obtain final product.
The preparation of embodiment 9 capsule
Weigh each crude drug (unit: g) by following weight: Rhizoma Polygonati 25, Caulis Spatholobi 25, Herb Gynostemmae Pentaphylli 25,
Herba Agrimoniae 25, Herba Bidentis Bipinnatae 18, Herba Diclipterae Chinensis 18, Radix Morindae Officinalis 18, Semen Vaccariae 18, Radix Dipsaci 10, Fructus Mori 10,
Radix Glycyrrhizae 4, Pseudobulbus cremastrae seu pleiones 9, Radix Adenophorae 9, Semen Coicis 7, Seem Lablab Album 5, Cortex Magnoliae Officinalis 5；Above-mentioned each crude drug is added water
Decocting secondary, add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5
Hour；Decoction liquor being merged, filter, it is the clear of 1.17-1.19 (60 DEG C) that filtrate is concentrated into relative density
Cream；Merge twice clear paste, add appropriate amount of starch, mixing, it is dried, pulverizes, adds appropriate amount of ethanol and make granule,
It is dried, granulate, fills capsule, to obtain final product.
The clinical observation on the therapeutic effect test of test example 1 traditional Chinese medicine composition for treating of the present invention tumor
One, physical data: 300 example patients all meet the diagnostic criteria of pulmonary carcinoma, hepatocarcinoma, wherein patients with lung cancer 150
Example, liver cancer patient 150 example.Age 25～80 years old.150 example pulmonary carcinoma and 150 example liver cancer patients are all distinguished
It is randomly divided into 3 groups, often organizes 50 examples；3 groups on sex, age, the course of disease and coincident with severity degree of condition difference without
Significance.
Two, trial drug
Medicine prepared by embodiment of the present invention 1-9.
Three, Therapeutic Method
150 example pulmonary carcinoma and 150 example liver cancer patients are randomly divided into 3 groups the most respectively, it may be assumed that test 1 group, examination
Test 2 groups and test 3, often organize each 50 examples, test 1 group of capsule treatment used prepared by embodiment 1-3,
Test 2 groups of capsule treatments used prepared by embodiment 4-6, test 3 groups and use embodiment 7-9 made
Standby capsule treatment；Oral, one time 3 (0.3g crude drug/grain), 3 times on the one, 10 days be a course for the treatment of,
6 courses for the treatment of of treatment altogether；Other related drugs and other treatment is withdrawn during taking medicine.
Four, efficacy assessment standard
Effective: cancerous cell reduces, and immunity increases, energetic, painless；
Effective: cancerous cell is substantially achieved suppression, immunity improves, and spirit is not good enough, pain relief；
Invalid: cancerous cell is constant, mental status is poor, still has pain, and symptom is obvious.
Five, clinical observation result
Clinical observation result is shown in Table 1-2.
The clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating of the present invention pulmonary carcinoma
The clinical observation on the therapeutic effect result of the test of table 2 traditional Chinese medicine composition for treating of the present invention hepatocarcinoma
Clinical observation on the therapeutic effect result shows, Chinese medicine composition of the present invention has significant curative effect for tumor patient；
Safety observations finds, does not observe any clinical adverse, shows that Chinese medicine composition of the present invention is clinical
Application safety, have no side effect.
Claims (4)
1. treat a Chinese medicine composition for tumor, be made up of each crude drug of following weight portion: Rhizoma Polygonati 20-40 part, Caulis Spatholobi 20-40 part, Herb Gynostemmae Pentaphylli 20-40 part, Herba Agrimoniae 20-40 part, Herba Bidentis Bipinnatae 15-35 part, Herba Diclipterae Chinensis 15-35 part, Radix Morindae Officinalis 15-35 part, Semen Vaccariae 15-35 part, Radix Dipsaci 8-20 part, Fructus Mori 8-20 part, Radix Glycyrrhizae 2-10 part, Herba Verbenae 5-10 part, Radix Angelicae Sinensis 5-10 part, Radix Paeoniae Rubra 4-8 part, Spina Gleditsiae 4-8 part and Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 4-8 part.
2. according to the Chinese medicine composition described in claim 1, it is characterized in that, the weight portion of each crude drug is: Rhizoma Polygonati 25 parts, Caulis Spatholobi 25 parts, Herb Gynostemmae Pentaphylli 25 parts, Herba Agrimoniae 25 parts, Herba Bidentis Bipinnatae 18 parts, Herba Diclipterae Chinensis 18 parts, Radix Morindae Officinalis 18 parts, Semen Vaccariae 18 parts, Radix Dipsaci 10 parts, 10 parts of Fructus Mori, 4 parts of Radix Glycyrrhizae, Herba Verbenae 8 parts, Radix Angelicae Sinensis 8 parts, Radix Paeoniae Rubra 6 parts, Spina Gleditsiae 6 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 6 parts.
3. the method preparing Chinese medicine composition described in claim 1 or 2, comprises the following steps:
(1), each crude drug is weighed by described weight proportion；
(2) by each crude drug soak by water, merging decoction liquor, filter, filtrate is condensed into clear paste, adds adjuvant or excipient, the preparations shaping of preparations shaping, to obtain final product.
4. the purposes in preparation tumor of the Chinese medicine composition described in claim 1 or 2.
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