CN105327205A - Traditional Chinese medicine preparation for treating thyroid cancer - Google Patents

Traditional Chinese medicine preparation for treating thyroid cancer Download PDF

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Publication number
CN105327205A
CN105327205A CN201510872293.7A CN201510872293A CN105327205A CN 105327205 A CN105327205 A CN 105327205A CN 201510872293 A CN201510872293 A CN 201510872293A CN 105327205 A CN105327205 A CN 105327205A
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parts
chinese medicine
medicine preparation
radix
herba
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宁建红
张宁
崔晓梅
徐海霞
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Qingdao Central Hospital
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Qingdao Central Hospital
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
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    • A61K36/06—Fungi, e.g. yeasts
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    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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Abstract

The invention discloses a traditional Chinese medicine preparation for treating thyroid cancer, and belongs to the technical field of medicines for treating thyroid cancer. The traditional Chinese medicine preparation is prepared from wolfiporia extensa, codonopsis pilosula, loranthus parasiticus, lentinus edodes, red beans, the root bark of white mulberry, the bark of eucommia, akebiaquinata, lignum dalbergiae odoriferae, bighead atractylodes rhizome, fiveleaf akebia fruits, arisacma consanguineum, pawpaw, hairyvein agrimony, semen coicis, garden burnet, cynanchum glaucescens, Chinese lobelia, folium cycas, hedyotis diffusa, indigo naturalis, cinnamon, subprostrate sophora, polygala tenuifolia, rhizoma alismatis, honeysuckle, panax notoginseng, peach kernels, centipedes and a Chinese starjasmine stem. The traditional Chinese medicine preparation is obtained through reasonable and scientific compatibility of the Chinese herbal medicines, the medicine effects complement each other and directly reach the focus depth place, transfer and spreading of thyroid cancer cells are effectively controlled, meanwhile, the immunologic function of the human body can be enhanced, growth of cancer cells is restrained, and no toxic or side effect is produced; lumps can be reduced within a short period of time, transfer is controlled, pain is relieved, the illness state is stabilized, the life time is prolonged, and clinical cure is achieved; the medicine property is gentle, and the traditional Chinese medicine preparation is gentle, and easy and convenient to take.

Description

A kind of Chinese medicine preparation for the treatment of thyroid carcinoma
Technical field
The invention belongs to the technical field of the medicine for the treatment of thyroid carcinoma, refer to a kind of Chinese medicine preparation for the treatment of thyroid carcinoma especially.
Background technology
Thyroid carcinoma is the more common malignant tumor of incidence, accounts for the l-2% of whole body malignant tumor, common with women, is found in any age bracket.At present, the sickness rate of thyroid carcinoma is in the trend significantly risen year by year.Thyroid carcinoma is divided into the polytypes such as papillary adenocarcinoma, filter blocking cancer, undifferentiated carcinoma, medullary carcinoma.Early clinical manifestation is not obvious, many no conscious symptons, and neck region lump is often asymmetry lump.Lump easily comparatively early produces pressure symptom, and as with hoarseness, hypopnea, dysphagia, or the pressure symptom such as local tenderness, during jugular vein pressurized, can occur the signs such as Ipsilateral venous engorgement and facial edema.
At present, increasing evidence shows that Chinese medicine can effectively grow, shift, spread by Tumor suppression, shortens the band tumor time of patient, reaches the object of killing tumor suppression cell; Meanwhile, can also improve the immunocompetence of body and the ability of regulation and control of organismic internal environment, effectively protect and improve the resistance against diseases of body, its late result and long-term survival rate all have a significant effect.
Current, although the Chinese medicine for the treatment of thyroid carcinoma has a variety of, still there are two aspect deficiencies in it: one is that effect is obvious not, two be take effect slower.A large amount of patients with thyroid neoplasm because of medicine can not effectively Tumor suppression growth, transfer, diffusion, have impact on band tumor existence time, patient and family members thereof are satisfaction not to this.
Summary of the invention
The invention provides a kind of Chinese medicine preparation for the treatment of thyroid carcinoma, solve in prior art Chinese medicine course for the treatment of for the treatment of thyroid carcinoma long, take effect slow and affect the problem of the life quality of patient.
A kind of Chinese medicine preparation for the treatment of thyroid carcinoma of the present invention, it mainly realizes by the following technical programs so in addition: the raw material comprising following weight portion: Poria 10-15 part, Radix Codonopsis 15-20 part, Herba Taxilli 8-12 part, Lentinus Edodes 10-15 part, Semen Phaseoli 8-12 part, Cortex Mori 8-12 part, Cortex Eucommiae 10-15 part, Caulis Akebiae 10-15 part, Lignum Dalbergiae Odoriferae 8-12 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Fructus Akebiae 10-15 part, Rhizoma Arisaematis (processed) 10-15 part, Fructus Chaenomelis 8-12 part, Herba Agrimoniae 10-15 part, Semen Coicis 8-12 part, Radix Sanguisorbae 8-12 part, Rhizoma Cynanchi Stauntonii 10-15 part, Herba Lobeliae Chinensis 10-15 part, Folium cordylines fruticosae 8-12 part, Herba Hedyotidis Diffusae 15-20 part, Indigo Naturalis 10-15 part, Cortex Cinnamomi 8-12 part, Radix Sophorae Tonkinensis 15-20 part, Radix Polygalae 10-15 part, Rhizoma Alismatis 8-12 part, Flos Lonicerae 15-20 part, Radix Notoginseng 8-12 part, Semen Persicae 8-12 part, Scolopendra 8-12 part, Caulis Trachelospermi 10-15 part.
As the preferred embodiment of one, comprise the raw material of following weight portion: 13 parts, Poria, Radix Codonopsis 18 parts, Herba Taxilli 10 parts, 12 parts, Lentinus Edodes, 10 parts, Semen Phaseoli, Cortex Mori 10 parts, the Cortex Eucommiae 12 parts, Caulis Akebiae 13 parts, Lignum Dalbergiae Odoriferae 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Akebiae 13 parts, Rhizoma Arisaematis (processed) 13 parts, Fructus Chaenomelis 10 parts, Herba Agrimoniae 13 parts, Semen Coicis 10 parts, Radix Sanguisorbae 10 parts, Rhizoma Cynanchi Stauntonii 13 parts, Herba Lobeliae Chinensis 12 parts, Folium cordylines fruticosae 10 parts, Herba Hedyotidis Diffusae 18 parts, Indigo Naturalis 13 parts, Cortex Cinnamomi 10 parts, Radix Sophorae Tonkinensis 18 parts, Radix Polygalae 13 parts, Rhizoma Alismatis 10 parts, Flos Lonicerae 18 parts, Radix Notoginseng 10 parts, 10 parts, Semen Persicae, Scolopendra 10 parts, Caulis Trachelospermi 12 parts.
As the preferred embodiment of one, the dosage form of described Chinese medicine preparation is oral liquid.
Pharmacological action:
In Chinese medicine preparation of the present invention: Poria: sweet in the mouth, property is put down; GUIXIN, lung, spleen channel; There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming; Cure mainly dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.
In Chinese medicine preparation of the present invention: Radix Codonopsis: sweet in the mouth, property is put down; Return spleen, lung meridian; Have matter profit gas and, there is spleen invigorating lung benefiting, benefiting QI and nourishing blood, the effect of promoting the production of body fluid; Cure mainly weakness of the spleen and stomach, anorexia and loose stool, fatigue and weakness, the deficiency of the lung is breathed with cough, lazy speech of breathing hard, spontaneous perspiration, and blood deficiency and yellow complexion is thirsty.
In Chinese medicine preparation of the present invention: Herba Taxilli: bitter sweet, property is put down; Return liver, kidney channel; There is invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive effect; Cure mainly soreness of waist and knee joint, muscles and bones flaccidity is weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery, chronic cough, and protrusion of the tongue is dizzy.
In Chinese medicine preparation of the present invention: Lentinus Edodes: property is put down, sweet in the mouth is nontoxic; Return stomach, Liver Channel; Have and strengthen the spleen and stomach, nourish blood and blood, the effect of rash of reducing phlegm; Cure mainly deficiency of spleen-QI and stomach-QI, anorexia and loose stool, not resistance to fatigue, be usually easy to flu; Or QI and blood deficiency, weak breath is weak, dizziness and blurred vision, and night sleeps not good enough.
In Chinese medicine preparation of the present invention: Semen Phaseoli: sweet in the mouth, property is put down, micro-acid; GUIXIN, small intestine meridian; There is diuretic dehumidifying, and blood evacuation of pus, effect of subduing swelling and detoxicating; Cure mainly edema, beriberi, jaundice, dysentery, have blood in stool, carbuncle.
In Chinese medicine preparation of the present invention: Cortex Mori: sweet in the mouth, cold in nature; Return lung meridian; There is eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema, repair effect of cicatrix; Cure mainly lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.
In Chinese medicine preparation of the present invention: the Cortex Eucommiae: sweet in the mouth, warm in nature; Return liver, kidney channel; There is invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect; Cure mainly spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, vaginal bleeding during pregnancy for falling, frequent fetal movement, hypertension.
In Chinese medicine preparation of the present invention: Caulis Akebiae: bitter in the mouth, property be light, be slightly cold; GUIXIN, lung, small intestinal, urinary bladder channel; There is clearing away heat and promoting diuresis, the effect of stimulating milk secretion of stimulating the menstrual flow; Cure mainly edema, gonorrhea, urinary obstruction, arthralgia, amenorrhea breast is few.
In Chinese medicine preparation of the present invention: Lignum Dalbergiae Odoriferae: property is pungent, tepor; GUIXIN, Liver Channel; There is clots absorbing, hemostasis, effect of analgesic therapy; Cure mainly traumatic injury congestive edema to have a pain, or card, the angina pectoris such as inside and outside is hemorrhage.
In Chinese medicine preparation of the present invention: the Rhizoma Atractylodis Macrocephalae: bitter in the mouth, property are sweet, tepor; Return spleen, stomach warp; There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect; Cure mainly insufficiency of the spleen lack of appetite, abdominal distention had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
In Chinese medicine preparation of the present invention: Fructus Akebiae: sweet in the mouth, cold in nature; Return liver,spleen,kidney warp; There is liver-smoothing, qi-regulating, invigorate blood circulation, eliminating stasis to stop pain, effect of relieving restlessness diuresis; Cure mainly stomachache due to hyperactive liver-QI attacking the stomach, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, menopause, and uterus drops.
In Chinese medicine preparation of the present invention: Rhizoma Arisaematis (processed): bitter in the mouth, property are pungent, tepor; Return lung, liver, spleen channel; There is drying dampness to eliminate phlegm, expelling wind and relieving convulsion, effect of mass dissipating and swelling eliminating; Cure mainly object for appreciation productive cough to cough, dizziness due to wind-phlegm, middle wind-phlegm is stopped up, and mouth eye is tiltedly askew, hemiplegia, epilepsy, infantile convulsion, tetanus.
In Chinese medicine preparation of the present invention: Fructus Chaenomelis: sweet in the mouth, property are put down, are slightly cold; Return liver, spleen channel; There is aid digestion, nourishing the lung to arrest cough, suppressing the hyperactive liver relaxing muscles and tendons, effect of stomach function regulating removing dampness; Cure mainly arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion of vomiting and diarrhoea, beriberi edema.
In Chinese medicine preparation of the present invention: Herba Agrimoniae: bitter in the mouth, property are pungent, micro-; Return lung, liver, spleen channel; There is effect of hemostasis, stomach invigorating; Main treatment blood, spit blood, hematuria, has blood in stool, dysentery, bleeding not during menses, and impairment caused by overstrain takes off power, carbuncle, traumatic injury, wound hemorrhage.
In Chinese medicine preparation of the present invention: Semen Coicis: sweet in the mouth, cool in nature, micro-light; Return spleen, stomach, lung meridian; Have spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, dense effect is arranged in heat clearing away; Cure mainly edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.
In Chinese medicine preparation of the present invention: Radix Sanguisorbae: bitter in the mouth, cold in nature; Return liver, lung, kidney, large intestine channel; There is cooling blood for hemostasis, heat-clearing and toxic substances removing, effect of detumescence sore; Cure mainly haematemesis, spitting of blood, epistaxis, hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting.
In Chinese medicine preparation of the present invention: Rhizoma Cynanchi Stauntonii: bitter in the mouth, property is pungent, tepor; Return lung meridian; There is sending down the abnormal ascending QI, expectorant, effect of cough-relieving; Cure mainly cough with copious phlegm, fullness in the chest dyspnea with rapid and short breath, excess of the lung dyspnea with fullness of the chest, gastralgia.
In Chinese medicine preparation of the present invention: Herba Lobeliae Chinensis: sweet in the mouth, property is put down; GUIXIN, lung, small intestine meridian; There is heat-clearing and toxic substances removing, effect of inducing diuresis to remove edema; Cure mainly venom, carbuncle furuncle, tonsillitis, warm rash, tinea pedis, traumatic injury, jaundice due to damp-heat, appendicitis, enteritis, nephritis, cirrhotic ascites and kinds cancer.
In Chinese medicine preparation of the present invention: Folium cordylines fruticosae: sweet in the mouth, property are light, micro-cool; Return spleen, stomach warp; There is heat clearing away, hemostasis, effect of dissipating blood stasis; Cure mainly dysentery, spit blood, have blood in stool, stomachache, hematuria, menorrhagia, traumatic injury.
In Chinese medicine preparation of the present invention: Herba Hedyotidis Diffusae: bitter in the mouth, property is sweet, is slightly cold; GUIXIN, liver, spleen channel; There is heat-clearing and toxic substances removing, clearing away heat-damp and promoting diuresis, heat clearing away dissipating blood stasis, effect of clear infantile malnutrition; Cure mainly dyspnea and cough due to lung-heat, tonsillitis, pharyngolaryngitis, appendicitis, dysentery, jaundice, pelvic inflammatory disease, adnexitis, carbuncle furuncle, venom.
In Chinese medicine preparation of the present invention: Indigo Naturalis: salty in the mouth, cold in nature; Return Liver Channel; There is heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, effect of pathogenic fire purging arresting convulsion; Cure mainly maculae caused by violent heat pathogen, heat in blood tells nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.
In Chinese medicine preparation of the present invention: Cortex Cinnamomi: sweet in the mouth, property is pungent, hot greatly; Return kidney, spleen, the heart and Liver Channel; There is benefit fire supporing yang, guiding fire to origin, dispersing cold for relieving pain, effect of promoting the flow of QI-blood by warming the meridian; Cure mainly sexual impotence cold womb, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, upward floating of YANG in deficiency condition, dizzy conjunctival congestion, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, and colic of cold type is suffered from abdominal pain, dysmenorrhea amenorrhea.
In Chinese medicine preparation of the present invention: Radix Sophorae Tonkinensis: bitter in the mouth, cold in nature, poisonous; Attach to the lung and stomach meridians; There is heat-clearing and toxic substances removing, effect of detumescence sore-throat relieving; Cure mainly fire-toxin to pent up, tonsillitis sore throat, laryngopharynx swelling and pain, gingivitis, aphtha of the mouth and tongue.
In Chinese medicine preparation of the present invention: Radix Polygalae: bitter in the mouth, property are pungent, tepor; GUIXIN, kidney, lung meridian; The effect of there is Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling; Cure mainly that the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration are not well, sore swollen toxin, breast swell and pain.
In Chinese medicine preparation of the present invention: Rhizoma Alismatis: sweet in the mouth, cold in nature; Return kidney, urinary bladder channel; There is diuretic, eliminating dampness by diuresis, the effect expelled the heat-evil; Cure mainly dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.
In Chinese medicine preparation of the present invention: Flos Lonicerae: property is pungent, sweet in the mouth, micro-hardship; Return lung, stomach, the heart, large intestine channel; There is resisting pathogenic microbes, antibacterial and sterilization, anti inflammatory detoxication, dredge effect of loose evil, the eliminating pathogenic heat from blood to cure dysentery of heat; Cure mainly the diseases such as febrile disease due to summer-heat pathogen, dysentery, influenza, furuncle toxic swelling, acute and chronic tonsillitis, periodontitis.
In Chinese medicine preparation of the present invention: Radix Notoginseng: sweet in the mouth, micro-hardship, warm in nature; Return liver, stomach warp; There is dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain; Cure mainly spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.
In Chinese medicine preparation of the present invention: Semen Persicae: property is put down, sweet in the mouth, micro-hardship; GUIXIN, liver, large intestine channel; There is blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, effect of relieving cough and asthma; For amenorrhea dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, lung abscess acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.
In Chinese medicine preparation of the present invention: Scolopendra: property is pungent, tepor; Return Liver Channel; There is endogenous wind stopping spasmolytic, dispersing pathogen accumulation, effect of removing obstruction in the collateral to relieve pain; Cure mainly infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.
In Chinese medicine preparation of the present invention: Caulis Trachelospermi: bitter in the mouth, be slightly cold; GUIXIN, liver, kidney channel; There is expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, clearing away heat and cooling blood, effect of removing toxic substances and promoting subsidence of swelling; Cure mainly dispelling wind and removing obstruction in the collateral, removing heat from blood is subsided a swelling, beriberoid pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.
Usage of the present invention and consumption: Chinese medicine preparation of the present invention, each 25mL, every day 2 times 2 weeks is a course for the treatment of, takes 4 courses for the treatment of continuously.
Beneficial effect of the present invention: Chinese medicine preparation of the present invention is the theory according to traditional Chinese medical science the body resistance strengthening and constitution consolidating, channels sootheing and network vessel quickening, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing and dispersing swelling and dissipating binds, is formed by the reasonable scientific compatibility of Chinese medicine medicines; Drug effect complements each other, and brings out the best in each other, and has effect of drying dampness to eliminate phlegm, benefiting QI for activating blood circulation, inducing menstruation to relieve menalgia, and through focus depths, effectively controls the metastasis and extension of thyroid carcinoma cell; Meanwhile, can also eliminating pathogen from the lung for relieving asthma, depressed liver-energy dispersing and QI regulating, invigorating the spleen and regulating the stomach, Fructus Alpiniae Oxyphyllae of calming the nerves, loosening bowel to relieve constipation, can enhancing human body immunity function, the growth of anticancer, does not have toxic and side effects; Lump can be reduced in a short time, control transfer, palliate the agonizing sufferings, stablize the state of an illness, extend life cycle, reach clinical cure; Its mild in medicine property and, gentleness easily takes, taking convenience.
Detailed description of the invention
Be clearly and completely described technical scheme of the present invention below in conjunction with specific embodiments of the invention, obviously, described embodiment is only a part of embodiment of the present invention, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
A kind of Chinese medicine preparation for the treatment of thyroid carcinoma of the present invention, comprise the raw material of following weight portion: Poria 10-15 part, Radix Codonopsis 15-20 part, Herba Taxilli 8-12 part, Lentinus Edodes 10-15 part, Semen Phaseoli 8-12 part, Cortex Mori 8-12 part, Cortex Eucommiae 10-15 part, Caulis Akebiae 10-15 part, Lignum Dalbergiae Odoriferae 8-12 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Fructus Akebiae 10-15 part, Rhizoma Arisaematis (processed) 10-15 part, Fructus Chaenomelis 8-12 part, Herba Agrimoniae 10-15 part, Semen Coicis 8-12 part, Radix Sanguisorbae 8-12 part, Rhizoma Cynanchi Stauntonii 10-15 part, Herba Lobeliae Chinensis 10-15 part, Folium cordylines fruticosae 8-12 part, Herba Hedyotidis Diffusae 15-20 part, Indigo Naturalis 10-15 part, Cortex Cinnamomi 8-12 part, Radix Sophorae Tonkinensis 15-20 part, Radix Polygalae 10-15 part, Rhizoma Alismatis 8-12 part, Flos Lonicerae 15-20 part, Radix Notoginseng 8-12 part, Semen Persicae 8-12 part, Scolopendra 8-12 part, Caulis Trachelospermi 10-15 part.
Particularly, comprise the raw material of following weight portion: 13 parts, Poria, Radix Codonopsis 18 parts, Herba Taxilli 10 parts, 12 parts, Lentinus Edodes, 10 parts, Semen Phaseoli, Cortex Mori 10 parts, the Cortex Eucommiae 12 parts, Caulis Akebiae 13 parts, Lignum Dalbergiae Odoriferae 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Akebiae 13 parts, Rhizoma Arisaematis (processed) 13 parts, Fructus Chaenomelis 10 parts, Herba Agrimoniae 13 parts, Semen Coicis 10 parts, Radix Sanguisorbae 10 parts, Rhizoma Cynanchi Stauntonii 13 parts, Herba Lobeliae Chinensis 12 parts, Folium cordylines fruticosae 10 parts, Herba Hedyotidis Diffusae 18 parts, Indigo Naturalis 13 parts, Cortex Cinnamomi 10 parts, Radix Sophorae Tonkinensis 18 parts, Radix Polygalae 13 parts, Rhizoma Alismatis 10 parts, Flos Lonicerae 18 parts, Radix Notoginseng 10 parts, 10 parts, Semen Persicae, Scolopendra 10 parts, Caulis Trachelospermi 12 parts.
Preferably, the dosage form of described Chinese medicine preparation is oral liquid.
embodiment one
A kind of Chinese medicine preparation for the treatment of thyroid carcinoma of the present invention, comprise the raw material of following weight portion: 10 parts, Poria, Radix Codonopsis 15 parts, Herba Taxilli 8 parts, 10 parts, Lentinus Edodes, 8 parts, Semen Phaseoli, Cortex Mori 8 parts, the Cortex Eucommiae 10 parts, Caulis Akebiae 10 parts, Lignum Dalbergiae Odoriferae 8 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Fructus Akebiae 10 parts, Rhizoma Arisaematis (processed) 10 parts, Fructus Chaenomelis 8 parts, Herba Agrimoniae 10 parts, Semen Coicis 8 parts, Radix Sanguisorbae 8 parts, Rhizoma Cynanchi Stauntonii 10 parts, Herba Lobeliae Chinensis 10 parts, Folium cordylines fruticosae 8 parts, Herba Hedyotidis Diffusae 15 parts, Indigo Naturalis 10 parts, Cortex Cinnamomi 8 parts, Radix Sophorae Tonkinensis 15 parts, Radix Polygalae 10 parts, Rhizoma Alismatis 8 parts, Flos Lonicerae 15 parts, Radix Notoginseng 8 parts, 8 parts, Semen Persicae, Scolopendra 8 parts, Caulis Trachelospermi 10 parts.
By above-mentioned raw materials, pulverize, mixing, adds water, and decocts, and sterilization, makes the oral liquid carried with; Certainly, also other pharmaceutically dosage forms such as pill, granule, tablet or capsule can be made.
embodiment two
A kind of Chinese medicine preparation for the treatment of thyroid carcinoma of the present invention, comprise the raw material of following weight portion: 13 parts, Poria, Radix Codonopsis 18 parts, Herba Taxilli 10 parts, 12 parts, Lentinus Edodes, 10 parts, Semen Phaseoli, Cortex Mori 10 parts, the Cortex Eucommiae 12 parts, Caulis Akebiae 13 parts, Lignum Dalbergiae Odoriferae 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Akebiae 13 parts, Rhizoma Arisaematis (processed) 13 parts, Fructus Chaenomelis 10 parts, Herba Agrimoniae 13 parts, Semen Coicis 10 parts, Radix Sanguisorbae 10 parts, Rhizoma Cynanchi Stauntonii 13 parts, Herba Lobeliae Chinensis 12 parts, Folium cordylines fruticosae 10 parts, Herba Hedyotidis Diffusae 18 parts, Indigo Naturalis 13 parts, Cortex Cinnamomi 10 parts, Radix Sophorae Tonkinensis 18 parts, Radix Polygalae 13 parts, Rhizoma Alismatis 10 parts, Flos Lonicerae 18 parts, Radix Notoginseng 10 parts, 10 parts, Semen Persicae, Scolopendra 10 parts, Caulis Trachelospermi 12 parts.
By above-mentioned raw materials, pulverize, mixing, adds water, and decocts, and sterilization, makes the oral liquid carried with; Certainly, also other pharmaceutically dosage forms such as pill, granule, tablet or capsule can be made.
embodiment three
A kind of Chinese medicine preparation for the treatment of thyroid carcinoma of the present invention, comprise the raw material of following weight portion: 15 parts, Poria, Radix Codonopsis 20 parts, Herba Taxilli 12 parts, 15 parts, Lentinus Edodes, 12 parts, Semen Phaseoli, Cortex Mori 12 parts, the Cortex Eucommiae 15 parts, Caulis Akebiae 15 parts, Lignum Dalbergiae Odoriferae 12 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Fructus Akebiae 15 parts, Rhizoma Arisaematis (processed) 15 parts, Fructus Chaenomelis 12 parts, Herba Agrimoniae 15 parts, Semen Coicis 12 parts, Radix Sanguisorbae 12 parts, Rhizoma Cynanchi Stauntonii 15 parts, Herba Lobeliae Chinensis 15 parts, Folium cordylines fruticosae 12 parts, Herba Hedyotidis Diffusae 20 parts, Indigo Naturalis 15 parts, Cortex Cinnamomi 12 parts, Radix Sophorae Tonkinensis 20 parts, Radix Polygalae 15 parts, Rhizoma Alismatis 12 parts, Flos Lonicerae 20 parts, Radix Notoginseng 12 parts, 12 parts, Semen Persicae, Scolopendra 12 parts, Caulis Trachelospermi 15 parts.
By above-mentioned raw materials, pulverize, mixing, adds water, and decocts, and sterilization, makes the oral liquid carried with; Certainly, also other pharmaceutically dosage forms such as pill, granule, tablet or capsule can be made.
Set forth the present invention further below in conjunction with concrete test example, wherein, comprise the animal toxicity test of Chinese medicine preparation of the present invention, pharmacodynamics test and clinical observation test.
animal toxicity test
Acute toxicity test: get adult rat 20, male and female dual-purpose, body weight 180-220g, be divided into two groups, often organizes 10; Chinese medicine preparation of the present invention is formed year rat oral gavage administrations according to 240 times and 350 times of clinical consumption per day to two respectively, observes 14, observe administration reaction every day; Test of many times all result shows, two groups of adult rats are all strong to be deposited, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction; Irritation test is carried out to adult rat oral cavity and damaged skin, there are no irritative response and other untoward reaction.This illustrates that Chinese medicine preparation of the present invention is little to adult rat acute use toxicity, application safety.
Long term toxicity test: separately get adult rat 20, male and female dual-purpose, body weight 180-220g, be divided into two groups, often organizes 10; Give adult rat gastric infusion, continuous use 16 weeks, every day 2 times by Chinese medicine preparation of the present invention according to 50 times of clinical consumption per day, observe administration reaction every day; Two groups of adult rats are respectively at medication 16 weeks and drug withdrawal after 4 weeks, and cut open inspection, carry out histological examination, naked eyes examine the situation of main inside internal organs; Result of the test shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to two groups of test adult rats all has no significant effect, and internal organs naked eyes do not find difference change; Histological indications shows, medication 16 weeks and drug withdrawal are after 4 weeks, and each internal organs of adult rat are all without obviously changing.This illustrates that Chinese medicine preparation of the present invention is little to toxicity after adult rat long-term prescription, does not also have difference reaction, application safety after drug withdrawal.
animal pharmacodynamics test
Get BALB/C-nu/nu strain nude mice 50,6-8 age in week, body weight 22-25g, male and female half and half; First in constant temperature, constant humidity and specified-pathogens free environment, nude mice adaptability is fed 1 week; Then, enter laboratory serial number by it, adopt lottery that it is divided into 5 groups at random, often organize 10, be respectively the experimental group of model group, the Chinese herbal medicine matched group of commercially available treatment thyroid carcinoma, the embodiment of the present invention one to embodiment three or three kinds of Chinese medicine preparation compositions.Under the state spiritual, movable, diet and two is just all good, by 5 groups of nude mices, outside two hips, the subcutaneous plantation of injection respectively 0.2mL(cell number is 5 × 10 6) human thyroid undifferentiated cancer cell TA-K.Wherein, by carrying out gastric infusion, model group such as to gavage at the normal saline of capacity in 5-20 days after inoculation oncocyte for 4 treatment groups and matched group and 3 experimental grouies; From the 21st day, observe 2 weeks again, close observation nude mice general status, become every size with vernier caliper measurement tumor nodule on the 1st after tumor, tumor volume approximate formula is a 2× b × 0.4(a is the minimum transverse diameter of tumor body, and b is the vertical height of tumor body, unit mm).
At the 21st day, respectively from 6 groups extract 1 nude mice and put to death, tumor body is taken off respectively and puts into 10% formalin and fix 2d, by paraffin embedding, cook slice and be placed on silanated slides.Take off paraffin with ethanol, after at every cm 2section adds E.C. 3.4.21.64 (20 μ g/mL) the pretreatment 15min of 12 μ L.Then the H of 3.0% is used 2o 2suppression process is carried out to the peroxidase of biopsy tissues, add terminal deoxyribonucleotidyl transferase after adding level pad and react 60min under 37 DEG C of conditions, add anti digoxin antibody working solution after adding stop buffer and at room temperature react 30min, add chromogenic substrate diaminobenzidine again, finally dye by C.I. 42590.Biopsy tissues adds a small amount of mountant, covered, at Microscopic observation.Positive control needs first at room temperature to process 10min with DNaseI to the liver section of Mus, then carries out above-mentioned steps; Negative control does not then add terminal deoxyribonucleotidyl transferase, and other steps are the same.Randomly draw 6 visuals field and carry out cell counting, count staining positive cells and total cell number under each visual field, and calculate apoptotic index (apoptotic index=staining positive cells/total cell number × 100%).
SPSS13.0 statistical software is adopted to carry out statistical analysis, result x ± s represents, many group different time points compare the variance analysis of employing repeated measure, the comparison one factor analysis of variance between many groups, P<0.05 is that difference has statistical significance, and experimental result is as shown in table 1.
Table 1 is group nude mouse tumor volume and apoptosis of tumor cells index test result respectively
Remarks: compared with model group, *---P<0.05, * *---P<0.01.
As can be seen from Table 1, compared with model group, three kinds of Chinese medicine preparation experimental grouies of matched group and the embodiment of the present invention one to embodiment three, it has the effect significantly suppressing thyroid tumor volume to increase, and the thyroid tumor volume of matched group and three experimental grouies reduces; Compared with matched group, three kinds of Chinese medicine preparation experimental grouies of the embodiment of the present invention one to embodiment three in the growth suppressing thyroid tumor volume advantageously.Meanwhile, in experimentation, model group does not find apoptosis staining positive cells substantially; Matched group and 3 experimental grouies obviously can increase the quantity of apoptosis staining positive cells; Compared with matched group, the apoptotic index of three kinds of Chinese medicine preparation of the embodiment of the present invention one to embodiment three obviously increases.Therefore, three kinds of Chinese medicine preparation of the embodiment of the present invention one to embodiment three increase at suppression thyroid tumor volume and promote to have obvious advantage in thyroid tumor apoptosis.
clinical observation is tested
Patient data
Choose 30-68 year thyroid cancer patients 400 example, wherein, man 180 example, female 220 example, the mean age is 55.37 years old; Be divided into four groups at random, be respectively a matched group and three treatment groups, often organize each 100 examples, do not have diversity statistically between four groups of patients, four groups of patients all meet the diagnostic criteria of thyroid carcinoma; These four groups of patients are before accepting this treatment, and all once with the Therapeutic Method such as Western medicine or Chinese medicine, but effect is not remarkable, easily recurs, can not dig up the roots.
Diagnostic criteria
Above selected patient all meet the thyroid carcinoma traditional Chinese medical science doctor diagnostic criteria, all show as have a delicate constitution, myasthenia of limbs, thyroid portion CT visual tumors, other important organ function of organization is normal.
Therapeutic scheme
Matched group: patient takes the Chinese herbal medicine of certain commercially available treatment thyroid carcinoma respectively orally, and it is decoction, one after each meal, every day 2 times, and each 200-300mL 1 month is 1 course for the treatment of, takes 4 courses for the treatment of continuously;
Treatment group: patient takes three kinds of Chinese medicine preparation of the embodiment of the present invention one to embodiment three respectively, and each 25mL(is equivalent to crude drug 3g), every day 2 times 2 weeks is 1 course for the treatment of, takes 4 courses for the treatment of continuously.
All experimenters all must not merge the medicine using other treatment thyroid carcinoma any and the medicine that may affect clinical efficacy and untoward reaction evaluation at duration of test.
Therapeutic effect
Recovery from illness: body constitution strengthens, and with it effectively, throat discomfort of neck area is obviously alleviated, CT shows thyroid region tumors tumor body to be reduced, and other position does not find nascent tumor.
Take a turn for the better: unable improvement with it, throat discomfort of neck area is alleviated, and CT shows thyroid portion tumor tumor body and has no growth, and other position does not find nascent tumor.
Invalid: all diseases are without improvement, and thyroid region tumors tumor body increases, or other positions find nascent tumor.
Clinical observation result
Table 2 clinical treatment outcome summary sheet
Group Number (example) Cure (example) Take a turn for the better (example) Invalid (example) Total effective rate (%)
Embodiment one 100 79 16 5 95
Embodiment two 100 81 15 4 96
Embodiment three 100 80 16 4 96
Matched group 100 58 23 19 81
As can be seen from Table 2, compared with matched group, three kinds of Chinese medicine preparation of the present invention all have good curative effect to treatment thyroid carcinoma, and clearly, cure rate and total effective rate obviously raise advantage, and cure rate reaches 80%, and total effective rate reaches 96%; Mild in medicine property and, without pained abnormal flavour, also do not have penetrating odor, gentleness easily takes, and patient carries out oral as drinking water; Easy to carry, be convenient to take; Short treating period, instant effect, determined curative effect, has no side effect.
Model case
Case 1: river, female, 54 years old, the conscious cervical region of patient swelled and ache, has hard object, and time angry, lump increases, and body constitution declines, weak all over, checked that CT shows thyroid portion tumor.Once took the Chinese herbal medicine of commercially available treatment thyroid carcinoma, this medicine thick taste, be difficult to swallow, after taking 3 months continuously, above-mentioned symptom does not improve, and lump increases gradually.Started afterwards to take Chinese medicine preparation of the present invention, each 25mL, every twice-daily; After taking a course for the treatment of, thyroid nodule, quality deliquescing, swallows smooth and easy; After taking two courses for the treatment of, health becomes light, and recheck, diameter of tumor reduces; Continue to take two courses for the treatment of, body constitution strengthens, with it effectively, rear neck detumescence, throat discomfort of neck area is obviously alleviated, and CT shows thyroid region tumors tumor body to be reduced, and other position does not find nascent tumor, reaches recovery from illness; Follow up a case by regular visits to 2 years, have no recurrence, health is good.
Case 2: grandson, man, 65 years old, there was lump in patient throat, lump surface irregularity, and sound is more hoarse, and body constitution declines, weak all over, checked that CT shows thyroid portion tumor.Once carried out hospitalization, continuous transfusion two weeks, without remarkable result, lump increases gradually; Also took the Chinese herbal medicine of commercially available treatment thyroid carcinoma afterwards, this medicine is decoction, thick taste, is difficult to swallow, and take inconvenience, after taking 3 months continuously, above-mentioned symptom does not improve, and lump increases gradually.Finally start to take Chinese medicine preparation of the present invention, each 25mL, every twice-daily; After taking two courses for the treatment of, the deliquescing of lump quality, size reduces, and swallows smooth and easy; Take a course for the treatment of again, health becomes light, and recheck, diameter of tumor reduces, and sound recovers gradually; Continue to take a course for the treatment of, body constitution strengthens, and with it effectively, lump is subsided a swelling, and throat discomfort of neck area is obviously alleviated, and CT shows thyroid region tumors reduced, and other position does not find nascent tumor, reaches recovery from illness; Follow up a case by regular visits to 3 years, have no recurrence, health is good.
Case 3: Wang, man, 31 years old, there was lump in patient throat, and up and down along with swallowing, edge blurry, general affairs surface irregularity, and sound is more hoarse, and body constitution declines, weak all over, checked that CT shows thyroid portion tumor.Once carried out hospitalization, continuous transfusion two weeks, without remarkable result, lump increases gradually.Started afterwards to take Chinese medicine preparation of the present invention, each 25mL, every twice-daily; After taking a course for the treatment of, lump reduces, and swallows smooth and easy; After taking two courses for the treatment of, health becomes light, and recheck, diameter of tumor reduces, and sound recovers gradually; Continue to take a course for the treatment of, body constitution strengthens, and with it effectively, lump is subsided a swelling, and throat discomfort of neck area is obviously alleviated, and CT shows thyroid region tumors reduced, and other position does not find nascent tumor, reaches recovery from illness; Follow up a case by regular visits to 1 year, have no recurrence, health is good.
Beneficial effect of the present invention: Chinese medicine preparation of the present invention is the theory according to traditional Chinese medical science the body resistance strengthening and constitution consolidating, channels sootheing and network vessel quickening, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing and dispersing swelling and dissipating binds, is formed by the reasonable scientific compatibility of Chinese medicine medicines; Drug effect complements each other, and brings out the best in each other, and has effect of drying dampness to eliminate phlegm, benefiting QI for activating blood circulation, inducing menstruation to relieve menalgia, and through focus depths, effectively controls the metastasis and extension of thyroid carcinoma cell; Meanwhile, can also eliminating pathogen from the lung for relieving asthma, depressed liver-energy dispersing and QI regulating, invigorating the spleen and regulating the stomach, Fructus Alpiniae Oxyphyllae of calming the nerves, loosening bowel to relieve constipation, can enhancing human body immunity function, the growth of anticancer, does not have toxic and side effects; Lump can be reduced in a short time, control transfer, palliate the agonizing sufferings, stablize the state of an illness, extend life cycle, reach clinical cure; Its mild in medicine property and, gentleness easily takes, taking convenience.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (3)

1. treat a Chinese medicine preparation for thyroid carcinoma, it is characterized in that, comprise the raw material of following weight portion:
Poria 10-15 part, Radix Codonopsis 15-20 part, Herba Taxilli 8-12 part, Lentinus Edodes 10-15 part, Semen Phaseoli 8-12 part, Cortex Mori 8-12 part, Cortex Eucommiae 10-15 part, Caulis Akebiae 10-15 part, Lignum Dalbergiae Odoriferae 8-12 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Fructus Akebiae 10-15 part, Rhizoma Arisaematis (processed) 10-15 part, Fructus Chaenomelis 8-12 part, Herba Agrimoniae 10-15 part, Semen Coicis 8-12 part, Radix Sanguisorbae 8-12 part, Rhizoma Cynanchi Stauntonii 10-15 part, Herba Lobeliae Chinensis 10-15 part, Folium cordylines fruticosae 8-12 part, Herba Hedyotidis Diffusae 15-20 part, Indigo Naturalis 10-15 part, Cortex Cinnamomi 8-12 part, Radix Sophorae Tonkinensis 15-20 part, Radix Polygalae 10-15 part, Rhizoma Alismatis 8-12 part, Flos Lonicerae 15-20 part, Radix Notoginseng 8-12 part, Semen Persicae 8-12 part, Scolopendra 8-12 part, Caulis Trachelospermi 10-15 part.
2. the Chinese medicine preparation for the treatment of thyroid carcinoma according to claim 1, is characterized in that, comprises the raw material of following weight portion:
13 parts, Poria, Radix Codonopsis 18 parts, Herba Taxilli 10 parts, 12 parts, Lentinus Edodes, 10 parts, Semen Phaseoli, Cortex Mori 10 parts, the Cortex Eucommiae 12 parts, Caulis Akebiae 13 parts, Lignum Dalbergiae Odoriferae 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Fructus Akebiae 13 parts, Rhizoma Arisaematis (processed) 13 parts, Fructus Chaenomelis 10 parts, Herba Agrimoniae 13 parts, Semen Coicis 10 parts, Radix Sanguisorbae 10 parts, Rhizoma Cynanchi Stauntonii 13 parts, Herba Lobeliae Chinensis 12 parts, Folium cordylines fruticosae 10 parts, Herba Hedyotidis Diffusae 18 parts, Indigo Naturalis 13 parts, Cortex Cinnamomi 10 parts, Radix Sophorae Tonkinensis 18 parts, Radix Polygalae 13 parts, Rhizoma Alismatis 10 parts, Flos Lonicerae 18 parts, Radix Notoginseng 10 parts, 10 parts, Semen Persicae, Scolopendra 10 parts, Caulis Trachelospermi 12 parts.
3. the Chinese medicine preparation for the treatment of thyroid carcinoma according to claim 1 and 2, is characterized in that:
The dosage form of described Chinese medicine preparation is oral liquid.
CN201510872293.7A 2015-12-02 2015-12-02 Traditional Chinese medicine preparation for treating thyroid cancer Pending CN105327205A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105582410A (en) * 2016-03-07 2016-05-18 李晓晓 Method for preparing traditional Chinese medicine composition for treating thyroid cancer
CN105617137A (en) * 2016-03-07 2016-06-01 李晓晓 Traditional Chinese medicine for treating thyroid cancer
CN105749033A (en) * 2016-03-07 2016-07-13 李晓晓 Preparation method of traditional Chinese medicine for treatment of thyroid carcinoma
CN105878600A (en) * 2016-05-19 2016-08-24 李丽丽 Traditional Chinese medicine preparation for treating thyroid cancer and preparation method thereof
CN105902733A (en) * 2016-05-19 2016-08-31 李丽丽 Preparation with thyroid cancer resisting function for ultrasonography and preparation method thereof
CN105998540A (en) * 2016-05-19 2016-10-12 李丽丽 Laboratory medicine stasis-removing preparation for treating thyroid cancer and method of preparing same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104256648A (en) * 2014-10-25 2015-01-07 胡安然 Total-nutrient formula food for thyroid cancer
CN104474281A (en) * 2014-12-10 2015-04-01 孙娅萍 Traditional Chinese medicine formula for treating thyroid cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104256648A (en) * 2014-10-25 2015-01-07 胡安然 Total-nutrient formula food for thyroid cancer
CN104474281A (en) * 2014-12-10 2015-04-01 孙娅萍 Traditional Chinese medicine formula for treating thyroid cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
何丽美: "110例甲状腺癌术后患者中医证型特征及用药特点", 《辽宁中医杂志》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105582410A (en) * 2016-03-07 2016-05-18 李晓晓 Method for preparing traditional Chinese medicine composition for treating thyroid cancer
CN105617137A (en) * 2016-03-07 2016-06-01 李晓晓 Traditional Chinese medicine for treating thyroid cancer
CN105749033A (en) * 2016-03-07 2016-07-13 李晓晓 Preparation method of traditional Chinese medicine for treatment of thyroid carcinoma
CN105878600A (en) * 2016-05-19 2016-08-24 李丽丽 Traditional Chinese medicine preparation for treating thyroid cancer and preparation method thereof
CN105902733A (en) * 2016-05-19 2016-08-31 李丽丽 Preparation with thyroid cancer resisting function for ultrasonography and preparation method thereof
CN105998540A (en) * 2016-05-19 2016-10-12 李丽丽 Laboratory medicine stasis-removing preparation for treating thyroid cancer and method of preparing same

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Application publication date: 20160217