CN1137393A - Yisuishengxue Chinese medicine preparation for tonifying marrow and promoting generation of blood - Google Patents
Yisuishengxue Chinese medicine preparation for tonifying marrow and promoting generation of blood Download PDFInfo
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Abstract
The main ingredients of the invented Yisuishengxue Chinese medicine preparation are red ginseng, cornus fruit, tortoise plastron glue, turtle shell, morinda root, deerhorn glue, Chinese angelica root, millettia root and stem, agrimony and indigo. Said Chinese medicine preparation has the functions of promoting hematopoiesis of bone marrow, raising blood cells and hemoglobin, promoting synthesis of DNA, regulating humoral immunity and cell immunity of the organism.
Description
The present invention relates to a kind of Chinese medicine preparation for the treatment of myelodysplastic syndrome.
Myelodysplastic syndrome (be called for short MDS), be one group of refractory anemia or with other cytopenia the disorderly syndrome of heterogeneity hemopoietic function of myeloproliferative disorder.Described one group of refractory anemia has (1) refractory anemia type (RA); (2) refractory anemia companion ring-type sideroblast type (RA-S); (3) refractory anemia with excess of blasts type (RAEB); (4) refractory anemia with excess of blasts is at transition phase type (RAEB-T), MDS is often because of infection, hemorrhage or dead to the acute myeloid leukaemia conversion, be that current hematology worker both at home and abroad pays close attention to most and need one of assistant officer's difficult disease to be studied the countermeasure, tackling key problem disease, both at home and abroad to the treatment shortage produce effects medicine of MDS, radical cure does not more have good method at present.Existing conventional hematopoietic curative effect is not remarkable, adrenocortical hormone, androgen and chemotherapeutics not only effect are undesirable, and toxic and side effects is bigger, not only kill and wound normal hemocyte, reduce the function of exempting from service, cause infecting and hemorrhage chance increases, and cause easily that a sodium water small piece of land surrounded by water is stayed, blood pressure increases, blood glucose metabolism disorder and cause iatrogenic diabetes etc.In recent years, adopt the bone marrow transplantation therapy better, but, be difficult to popularize because of being subjected to the restriction of economic condition and medical condition to the MDS curative effect.Beijing College of Traditional Chinese Medicine, adopting " supplementing QI and nourishing YIN activating blood circulation method " to take Chinese medicine benefit marrow spirit treatment 32, example is clinical now examines, and its total effective rate is 81.25%, though certain effect has been arranged, its curative effect is also undesirable.
The purpose of this invention is to provide a kind of Chinese medicine preparation, have curative effect height, relapse rate low, have no side effect cheap characteristics.
A kind of Chinese medicine preparation of beneficial marrow hemopoietic has been realized above-mentioned purpose, and it comprises the medicine of following five class effects:
(1) replenishing QI to invigorate the spleen: Radix Ginseng Rubra or Radix Codonopsis,
(2) nourishing YIN and supplementing blood: Fructus Corni, Colla Plastri Testudinis (or Carapax et Plastrum Testudinis), Carapax Trionycis,
(3) beneficial marrow tonifying YANG: Radix Morindae Officinalis,
(4) blood-supplementing blood-nourishing: Colla cornus cervi (or Cornu Cervi Pantotrichum), Radix Angelicae Sinensis,
(5) promoting blood circulation and hemostasis: Caulis Spatholobi, Herba Agrimoniae.
The present invention is based on 9 kinds of components of above-mentioned five class effects, and the medicine of every class effect can also be again and other medicine compatibility of this apoplexy due to endogenous wind, and according to drug effect, other each relatively more suitable component is:
(1) replenishing QI to invigorate the spleen: the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Dioscoreae, Poria, wherein 2～3 kinds, the preferred Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched);
(2) nourishing YIN and supplementing blood: Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Rhizoma Polygonati, Fructus Lycii, two mulberry, Herba Ecliptae, Radix Ophiopogonis, wherein 2～3 kinds, preferred Fructus Ligustri Lucidi, Radix Rehmanniae Preparata;
(3) beneficial marrow tonifying YANG: Cortex Cinnamomi, Herba Epimedii, Semen Cuscutae, Rhizoma Curculiginis, wherein 2～3 kinds, preferred Cortex Cinnamomi, Herba Epimedii;
(4) blood-supplementing blood-nourishing: in Colla Corii Asini, Radix Polygoni Multiflori, the Arillus Longan 1～3 kind, preferred Colla Corii Asini, Radix Polygoni Multiflori;
(5) promoting blood circulation and hemostasis: in Radix Notoginseng, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Rubiae, Nodus Nelumbinis Rhizomatis, Folium Artemisiae Argyi, Crinis Carbonisatus, brown charcoal, side uncle charcoal, the Herba Cirsii 1～3 kind, preferred Radix Notoginseng.
The present invention can also add the antipyretic and antidotal type medicine, is selected from 1～3 kind in Indigo Naturalis, Hedyotidis Diffusae, Herba Scutellariae Barbatae, Rhizoma Polygoni Cuspidati, the Pseudobulbus Cremastrae Seu Pleiones, preferred Indigo Naturalis.Such medicine adds the MDS of transition phase type disease in more serious refractory anemia with excess of blasts type of treatment and refractory anemia with excess of blasts, and the anemia of other type can not added, and is only favourable in addition and have no adverse effects.
The present invention has wherein adopted YIN nourishing and warming YANG class medicine, focus on tonifying both YIN and YANG, and selection has active strong component, play replenishing QI to invigorate the spleen, nourishing kidney benefit marrow, passage, nourishing blood, promoting tissue regeneration by removing blood stasis, heat-clearing and toxic substances removing altogether, set upright the effect that resists heresy, kidney essense Sheng, change source foot, negative and positive coordination, anemia are cured, therefore make the present invention have unique curative effect.
Through pharmacological research and clinical observation, each Chinese medicinal components of selection is when participating in compatibility, when selecting following consumption the most effectively (referring to the crude drug consumption, in parts by weight):
Radix Ginseng Rubra 5～20 (or Radix Codonopsis 10～30), the Radix Astragali 10～60, Rhizoma Atractylodis Macrocephalae (parched) 5～20, Rhizoma Dioscoreae 10～30, Poria 10～30, Fructus Corni 10～30, Colla Plastri Testudinis 10～20 (or Carapax et Plastrum Testudinis 10～30), Carapax Trionycis 10～30, Fructus Ligustri Lucidi 10～30, Radix Rehmanniae Preparata 10～30, Rhizoma Polygonati 10～30, Fructus Lycii 10～30, two mulberrys 10～30, Herba Ecliptae 10～30, Radix Ophiopogonis 10～15, Radix Morindae Officinalis 10～20, Cortex Cinnamomi 3～10, Herba Epimedii 10～30, Semen Cuscutae 10～30, Rhizoma Curculiginis 10～20, Colla cornus cervi 10～20 (or Cornu Cervi Pantotrichum 5～10), Radix Angelicae Sinensis 10～30, Colla Corii Asini 10～20, Radix Polygoni Multiflori 10～15, Arillus Longan 10～20, Caulis Spatholobi 10～30, Radix Notoginseng 2～10, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20, Radix Rubiae 10～30, Nodus Nelumbinis Rhizomatis 10～30, Folium Artemisiae Argyi, Crinis Carbonisatus, the palm fibre charcoal, side uncle charcoal, Herba Cirsii each 10～30.The amount that is higher than each component does not improve curative effect, is lower than its amount and just can lessens the curative effect.
Best group of the present invention becomes:
Radix Ginseng Rubra 15 (or Radix Codonopsis 30), the Radix Astragali 50, Rhizoma Atractylodis Macrocephalae (parched) 15, Fructus Corni 20, Colla Plastri Testudinis 20 (or Carapax et Plastrum Testudinis 30), Carapax Trionycis 20, Fructus Ligustri Lucidi 30, Radix Rehmanniae Preparata 30, Radix Morindae Officinalis 15, Cortex Cinnamomi 6, Herba Epimedii 18, Colla cornus cervi 20 (or Cornu Cervi Pantotrichum 5), Radix Angelicae Sinensis 20, Colla Corii Asini 20, Caulis Spatholobi 30, Herba Agrimoniae 30, Radix Notoginseng 5, Indigo Naturalis 4.
Wherein the Radix Codonopsis drug effect is lower than Radix Ginseng Rubra, and the Carapax et Plastrum Testudinis drug effect is lower than Colla Plastri Testudinis, and the Colla cornus cervi effect is lower than Cornu Cervi Pantotrichum, but Cornu Cervi Pantotrichum medicine source deficiency costs an arm and a leg, and Colla cornus cervi can be alternative fully.This best prescription prescription is tight, concise, drug effect is best.
Best dosage form of the present invention is a pill, taking convenience, and its manufacture method is the preparation method of Chinese patent medicine pill routinely, each Chinese medicinal components concocting method routinely.Also can make other dosage form according to a conventional method, as mixture, tablet etc.
By treating 65 routine patients' clinical observation, total effective rate is 91.7%, obvious effective rate 75%, and relapse rate is low, to its modern pharmacology analysis and research, have promote bone marrow hematogenesis, promote hemocyte and hemoglobin, promotion DNA synthetic, regulate effects such as humoral immunity of organism and cellular immunization, not only treat the MDS special effect, all kinds of anemia disease 816 examples (as aplastic anemia, leukemia, immune hemolytic anemia, iron deficiency anemia, megaloblastic anemia etc.) are also had significant curative effect.Because of having, it improves and the adjusting immunization, so some immunodeficiency diseases is also had therapeutical effect preferably, the old people had the health-care effect that anti-ageing labor fills blood, cause is Chinese herbal and crude drugs preparations sheerly, have no side effect taking convenience, and the low health of price, MDS provides a kind of specially good effect good medicine for treatment, all has unique curative effect than other Chinese medicine.
Case one:
Old * *, the woman, 50 years old, the cotton mill cadre of Urumqi City, Xinjiang, weak 2 years of the painful dizzy companion of the excuse whole body is surplus, increases the weight of half a year, examines on August 10th, 92.The dizzy headache of the self-induction of patient's unknown cause before 2 years, complexion is gradually yellow, the whole body is weak, once removed ground hospital admissions such as Urumqi City and Beijing, Tianjin, be diagnosed as MDS-RA, gave blood transfusion repeatedly through looking into bone marrow smear, oral stanozolol, revolving medicine treatments such as azoles and retinoic acid, effect does not show, and the present, I went to a doctor at institute.Have a medical check-up: the anemia looks, pale tongue, tongue is white, deep and weak pulse is unable, and blood test is conventional result show: Hb35g/L RBC1.13 * 10
12/ L PC50 * 10
9/ L, Western medicine diagnose: MDS-RA, tcm diagnosis: asthenia, dialectical: deficiency of spleen and stomach, insufficiency of vital energy and blood, give oral beneficial marrow SHENGXUE WAN, each 6g, day clothes three times cooperate stanozolol, Theragran and blood transfusion Supporting Therapy, after three months (courses of treatment), patient's diet increases, dizzy headache transference cure, and the whole body is more preceding strong.The check routine blood test is the result show: Hb56g/L RBC2.56 * 10
12/ L WBC2.3 * 10
9/ L PC76 * 10
9/ L, after clothes this medicine treatment (blood transfusion again) three courses of treatment, all cards of patient disappear, and have rosy cheeks, and the check routine blood test is the result show: Hb112g/L RBC4.26 * 10
12/ L WBC4.2 * 10
9/ L PC82 * 10
9/ L, the beneficial marrow SHENGXUE WAN of clothes that continues is consolidated curative effect, follows up a case by regular visits to and does not have recurrence in 1 year.
Case two:
Open * *, man, 24 years old, Manzhouli, Inner Mongol frontier guard, because of suffering from acute lymphoblastic leukemia (L2) 5 months, exhale city hospital combined chemotherapy through living the locality, change tens of chemotherapy regimens repeatedly, the commentaries on classics but the state of an illness is not got better, bone marrow smear fail to alleviate all the time, and leukocyte reduces to 0.3 * 10
9/ L was forced to interrupt chemotherapy, is decided to be the impatient pouring of refractory, lived my institute on June 14th, 94.Have a medical check-up: young man, pale tongue with white fur, thready and weak pulse, Western medicine diagnose: intractable acute lymphoblastic leukemia, tcm diagnosis: asthenia.Looking into the bone marrow smear result after being admitted to hospital shows: the children drenches 58.5%, promptly gives beneficial marrow SHENGXUE WAN oral, each 6g, day obeys three times, treated one month, the check bone marrow smear is the result show: the children drenches 45%, adds medicine to treatment after three months continue clothes, the all diseases of patient disappear, have rosy cheeks, the check bone marrow smear is the result show: alleviate (children drenches 3%) fully, do not use any chemotherapeutics during the hospitalization, the clothes that continue are added medicine to, and follow up a case by regular visits to and do not recur half a year.
Case three:
Open * *, the man, 32 years old, the worker of dress company is pressed in Zibo City's architectural engineering, because of suffering from chronic aplastic anemia 8 years, successively goes ground hospitalizes such as Jinan, Beijing, Feicheng, Shijiazhuang, use up RMB eight, 90,000 yuan, all the time the commentaries on classics of not getting better only depending on repeatedly that blood transfusion earns a bare living, and came my institute's diagnosis and treatment on June 13rd, 93.Have a medical check-up: middle-aged male, lusterless complexion, the lip and nail color is light, and pale tongue is fat, and deep and weak pulse is unable.The blood test routine is shown: Hb45g/L RBC1.6 * 10
12/ L WBC1.7 * 10
9/ L PC35 * 10
9/ L, Western medicine diagnose: chronic aplastic anemia, tcm diagnosis: asthenia, blood disorder, dialectical: QI and blood is two loses, and gives oral beneficial marrow SHENGXUE WAN, each 2 ball 12g, day obeys three times, and cooperate stanozolol, vitamin E ball, Gai Tianli and be interrupted blood transfusion Supporting Therapy after four months, all diseases of patient alleviate, and the state of an illness is clearly better, have rosy cheeks, the whole body is strong, the bimester of the beneficial marrow SHENGXUE WAN treatment of clothes after, check routine blood test result: Hb115g/L RBC3.85 * 10
12/ L WBC4.5 * 10
9/ L RC1.2%PC87 * 10
9/ L follows up a case by regular visits to and did not have recurrence in 1 year.
Embodiment one: most preferred embodiment
Radix Ginseng Rubra 15, the Radix Astragali 50, Rhizoma Atractylodis Macrocephalae (parched) 15, Fructus Corni 20, Colla Plastri Testudinis 20, Carapax Trionycis 20, Fructus Ligustri Lucidi 30, Radix Rehmanniae Preparata 30, Radix Morindae Officinalis 15, Cortex Cinnamomi 6, Herba Epimedii 18, Colla cornus cervi 20, Radix Angelicae Sinensis 20, Colla Corii Asini 20, Caulis Spatholobi 30, Herba Agrimoniae 30, Radix Notoginseng 5, Indigo Naturalis 4.
Each medicine of distinguishing the flavor of is ground into carefully not, and by traditional Chinese patent medicine concocting method, processing is concocted, and honey is combined into ball, and the heavy 6g of every ball whenever closes 10 balls dress.
The beneficial marrow SHENGXUE WAN made from above-mentioned Chinese medicine has significant curative effect to treatment MDS disease and all kinds of anemia.
Embodiment two: the best constituent of embodiment one selects for use amount ranges of the present invention all can.
Embodiment three: make pill with following medicine
Radix Ginseng Rubra 15, Rhizoma Dioscoreae 15, Poria 15, Fructus Corni 20, Colla Plastri Testudinis 20 (or Carapax et Plastrum Testudinis 30), Carapax Trionycis 20, Rhizoma Polygonati 20, Fructus Lycii 30, Radix Morindae Officinalis 15, Semen Cuscutae 18, Rhizoma Curculiginis 15, Colla cornus cervi 20, Radix Polygoni Multiflori 15, Radix Angelicae Sinensis 20, Caulis Spatholobi 30, Herba Agrimoniae 30, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15, Hedyotidis Diffusae 45.
Embodiment four: Radix Ginseng Rubra 20, the Radix Astragali 10, Rhizoma Atractylodis Macrocephalae (parched) 20, Rhizoma Dioscoreae 10, Fructus Corni 30, Colla Plastri Testudinis 10, Carapax Trionycis 30, Fructus Ligustri Lucidi 20, two mulberry 30, Herba Ecliptae 10, Radix Morindae Officinalis 20, Cortex Cinnamomi 3, Semen Cuscutae 10, Rhizoma Curculiginis 10, Colla cornus cervi 10, Radix Angelicae Sinensis 10, Arillus Longan 20, Caulis Spatholobi 30, Herba Agrimoniae 10, Radix Rubiae 10, Nodus Nelumbinis Rhizomatis 10.
Embodiment five:
Radix Ginseng Rubra 5, the Radix Astragali 60, Rhizoma Dioscoreae 30, Fructus Corni 10, Carapax et Plastrum Testudinis 30, Carapax Trionycis 10, Rhizoma Polygonati 10, Fructus Lycii 10, Radix Ophiopogonis 10, Radix Morindae Officinalis 15, Semen Cuscutae 30, Rhizoma Curculiginis 20, Colla cornus cervi 10, Colla Corii Asini 10, Radix Polygoni Multiflori 15, Arillus Longan 10, Caulis Spatholobi 10, Herba Agrimoniae 20, brown charcoal 10, Herba Scutellariae Barbatae 20, Rhizoma Polygoni Cuspidati 10, Pseudobulbus Cremastrae Seu Pleiones 10.
Claims (8)
1, a kind of beneficial marrow hemopoietic Chinese medicine preparation is characterized in that comprising the following traditional Chinese medicines component:
(1) replenishing QI to invigorate the spleen: Radix Ginseng Rubra or Radix Codonopsis,
(2) nourishing YIN and supplementing blood: Fructus Corni, Colla Plastri Testudinis (or Carapax et Plastrum Testudinis), Carapax Trionycis.
(3) beneficial marrow tonifying YANG: Radix Morindae Officinalis.
(4) blood-supplementing blood-nourishing: Colla cornus cervi (or Cornu Cervi Pantotrichum), Radix Angelicae Sinensis.
(5) promoting blood circulation and hemostasis: Caulis Spatholobi, Herba Agrimoniae.
2, Chinese medicine preparation according to claim 1 is characterised in that also to comprise the following traditional Chinese medicines component:
(1) replenishing QI to invigorate the spleen: in the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Dioscoreae, the Poria 2～3 kinds,
(2) nourishing YIN and supplementing blood: Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Rhizoma Polygonati, Fructus Lycii, two mulberry, Herba Ecliptae, in Radix Ophiopogonis 2～3 kinds.
(3) beneficial marrow tonifying YANG: in Cortex Cinnamomi, Herba Epimedii, Semen Cuscutae, the Rhizoma Curculiginis 2～3 kinds,
(4) blood-supplementing blood-nourishing: in Colla Corii Asini, Radix Polygoni Multiflori, the Arillus Longan 1～3 kind,
(5) promoting blood circulation and hemostasis: in Radix Notoginseng, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Rubiae, Nodus Nelumbinis Rhizomatis, Folium Artemisiae Argyi, Crinis Carbonisatus, brown charcoal, side uncle charcoal, the Herba Cirsii 1～3 kind.
3, Chinese medicine preparation according to claim 2 is characterised in that best constituent is:
(1) Radix Ginseng Rubra (or Radix Codonopsis), the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched).
(2) Fructus Corni, Colla Plastri Testudinis (or Carapax et Plastrum Testudinis), Carapax Trionycis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata,
(3) Radix Morindae Officinalis, Cortex Cinnamomi, Herba Epimedii,
(4) Colla cornus cervi (or Cornu Cervi Pantotrichum), Radix Angelicae Sinensis, Colla Corii Asini,
(5) Caulis Spatholobi, Herba Agrimoniae, Radix Notoginseng.
4,, be characterised in that to add the antipyretic and antidotal type medicine that mainly select 1～3 kind in Indigo Naturalis, Hedyotidis Diffusae, Herba Scutellariae Barbatae, Rhizoma Polygoni Cuspidati, the Pseudobulbus Cremastrae Seu Pleiones for use, the best is an Indigo Naturalis according to claim 1,2,3 Chinese medicine preparation.
5,, be characterised in that the consumption when each Chinese medicine component is participated in compatibility is (parts by weight) according to claim 1,2,3 Chinese medicine preparation:
Radix Ginseng Rubra 5～20 (or Radix Codonopsis 10～30), the Radix Astragali 10～60, Rhizoma Atractylodis Macrocephalae (parched) 5～20, Rhizoma Dioscoreae 10～30, Poria 10～30, Fructus Corni 10～30, Colla Plastri Testudinis 10～20 (or Carapax et Plastrum Testudinis 10～30), Carapax Trionycis 10～30, Fructus Ligustri Lucidi 10～30, Radix Rehmanniae Preparata 10～30, Rhizoma Polygonati 10～30, Fructus Lycii 10～30, two mulberrys 10～30, Herba Ecliptae 10～30, Radix Ophiopogonis 10～15, Radix Morindae Officinalis 10～20, Cortex Cinnamomi 3～10, Herba Epimedii 10～30, Semen Cuscutae 10～30, Rhizoma Curculiginis 10～20, Colla cornus cervi 10～20 (or Cornu Cervi Pantotrichum 5～10), Radix Angelicae Sinensis 10～30, Colla Corii Asini 10～20, Radix Polygoni Multiflori 10～15, Arillus Longan 10～20, Caulis Spatholobi 10～30, Herba Agrimoniae 10～30, Radix Notoginseng 2～10, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20, Radix Rubiae 10～30, Nodus Nelumbinis Rhizomatis 10～30, Folium Artemisiae Argyi, Crinis Carbonisatus, the palm fibre charcoal, side uncle charcoal, Herba Cirsii each 10～30.
6, Chinese medicine preparation according to claim 4 is characterised in that the consumption when each Chinese medicine component is participated in compatibility is (parts by weight):
Indigo Naturalis 2～6, Hedyotidis Diffusae 10～60, Herba Scutellariae Barbatae 10～30, Rhizoma Polygoni Cuspidati 10～15, Pseudobulbus Cremastrae Seu Pleiones 10～15.
7, Chinese medicine preparation according to claim 1 is characterised in that best Chinese drug-treated group becomes (parts by weight):
Radix Ginseng Rubra 15, the Radix Astragali 50, Rhizoma Atractylodis Macrocephalae (parched) 15, Fructus Corni 20, Colla Plastri Testudinis 20, Carapax Trionycis 20, Fructus Ligustri Lucidi 30, Radix Rehmanniae Preparata 30, Radix Morindae Officinalis 15, Cortex Cinnamomi 6, Herba Epimedii 18, Colla cornus cervi 20, Radix Angelicae Sinensis 20, Colla Corii Asini 20, Caulis Spatholobi 30, Herba Agrimoniae 30, Radix Notoginseng 5, Indigo Naturalis 4.
8, Chinese medicine preparation according to claim 1 is characterised in that to be pill.
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| CN95110503A CN1062144C (en) | 1995-06-08 | 1995-06-08 | Yisuishengxue chinese medicine preparation for tonifying marrow and promoting generation of blood |
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| CN95110503A CN1062144C (en) | 1995-06-08 | 1995-06-08 | Yisuishengxue chinese medicine preparation for tonifying marrow and promoting generation of blood |
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