CN103055147A - Plaster medicine used for treating chronic aplastic anemia, and preparation method thereof - Google Patents
Plaster medicine used for treating chronic aplastic anemia, and preparation method thereof Download PDFInfo
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- CN103055147A CN103055147A CN2013100047037A CN201310004703A CN103055147A CN 103055147 A CN103055147 A CN 103055147A CN 2013100047037 A CN2013100047037 A CN 2013100047037A CN 201310004703 A CN201310004703 A CN 201310004703A CN 103055147 A CN103055147 A CN 103055147A
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Abstract
The invention relates to a plaster medicine used for treating chronic aplastic anemia, and a preparation method thereof. The medicine is characterized in that the medicine is composed of a yin-deficiency plaster medicine. The yin-deficiency plaster medicine is prepared from 25-35g of prepared rehmannia rhizome, 25-35g of tortoise-shell glue, 10-20g of ligusticum, 10-20g of ass-hide gelatin, 3-6g of radix notoginseng, and 3-6g of common bletilla tuber. The medicine provided by the invention has the advantages such as convenient application, good curative effect, low side effect, and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine that sticks, particularly relate to treat chronic aplastic anemia stick medicine and preparation method, this plaster spreads on SHENYU point during use.
Background technology
Chronic aplastic anemia (is called for short chronic aplastic anemia, chronic aplastic anemia, CAA) because the many factors such as physics, chemistry, biology cause hemopoietic function of bone marrow to subtract the disease of depletion, pancytopenia, commonly encountered diseases and the frequently-occurring disease of blood system, at China's sickness rate 6.1/10 ten thousand, account for 12% of disease in the blood system.Its clinical manifestation be anemia, hemorrhage, infect, take anemia as main, its onset hide, is made slow progress, course of disease delay is difficult, though can alleviate after the treatment, very easily recurs.At present, the western medical treatment chronic aplastic anemia adopts androgen, immunosuppressant, hematopoietic cell growth factor etc. more, although evident in efficacy, but the unstability of its curative effect and drug side effect thereof such as liver, nephrotoxicity, gastrointestinal reaction, virilization etc. have a strong impact on patient's existence and quality of life.Though TCM Document is without this name of disease of chronic aplastic anemia, belong to the category of " blood deficiency " " asthenia " according to its clinical symptoms, its treatment there is it from ancient times, the Systematic therapy scheme centered by kidney that formed modern times.Kidney governing bones, living marrow, store essential substances, although the essence and blood sharing the same origin theory thinks that aplastic anemia shows as QI and blood deficiency, but it is kidney at all, deficiency of kidney-essence, kidney is store essential substances, living marrow not, oligospermia is not changed less hemopoietic and cause this disease not of blood, marrow, and has formed gradually the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs system centered by kidney, and kidney tonifying, essence replenishing, blood-nourishing blood-generating are its base therapy principles.Chinese medicine participates in the chronic aplastic anemia treatment and all demonstrate obvious curative effects in clinical practice and experimentation, and low price, is easilier accepted by the patient.Modern experimentation shows that kidney-nourishing tcm drug all can promote hemopoietic progenitor cell colony forming unit (CFU-F) propagation in the bone marrow, hemopoietic stem cell growth; Simultaneously by suppressing short apoptosis factor such as downward modulation Fas protein expression, the activity that suppresses crucial kinase c asasse-3, or increase anti-apoptosis factor as increasing bone marrow CD34+ cell bcl-2 protein expression, coordinate the apoptosis of Hematopoietic Stem/group cell, thereby recover hemopoietic function of bone marrow.Strengthening spleen, tonifying kidney Chinese medicine promotes bone marrow hematogenesis by improving immunologic function, and it can improve the ratio of T lymphocyte subgroup, and CD4+/CD8+ returns to normal level, suppress the Ts function, increase the NK cytoactive, reduce simultaneously hemopoietic negative regulatory factor TNF-α, 1FN-γ, the releases such as IL-2.Then by promoting marrow fibroblast, hemopoietic progenitor cell colony forming unit (CFU-F), CFU-E (CFU-E) propagation are improved hematopoiesis microcirculation to blood-activating and stasis-removing, accelerate metabolism, promote bone marrow regeneration.
Summary of the invention
Purpose of the present invention is the medicine that sticks of open treatment chronic aplastic anemia, and this medicine is easy to use, good effect, and side effect is little.
Another object of the present invention provides a kind of preparation method of this medicine.
The technical scheme that adopts is:
Treat the medicine that sticks of chronic aplastic anemia, it is characterized in that pasting ingredients by the deficiency of YIN.
The deficiency of YIN is pasted medicine, is to be prepared into by Radix Rehmanniae Preparata 25-35g, Colla Plastri Testudinis 25-35g, Radix Angelicae Sinensis 10-20g, Colla Corii Asini 10-20g, Radix Notoginseng 3-6g and Pseudobulbus Bletillae (Rhizoma Bletillae) 3-6g.
The preparation method that sticks medicine for the treatment of chronic aplastic anemia comprises the steps:
1, get the raw materials ready:
Get Radix Rehmanniae Preparata, Colla Plastri Testudinis, Radix Angelicae Sinensis, Colla Corii Asini, Radix Notoginseng and the Pseudobulbus Bletillae (Rhizoma Bletillae), oven dry is ground into fine powder respectively, crosses 200 mesh sieves, and splendid attire is for subsequent use respectively.
2, the preparation deficiency of YIN is pasted medicine:
Get Radix Rehmanniae Preparata powder 25-35g, Carapax Et Plastrum Testudinis rubber powder 25-35g, Radix Angelicae Sinensis powder 10-20g, Colla Corii Asini powder 10-20g, Radix Notoginseng powder 3-6g and Pseudobulbus Bletillae (Rhizoma Bletillae) powder 3-6g, it is even to be mixed, and get final product.
The using method that sticks medicine for the treatment of chronic aplastic anemia of the present invention:
Select SHENYU point for sticking a little, get the deficiency of YIN and paste medicine 6.6g, add the 4ml distilled water and make paste, place diameter 2.5cm plaster central authorities to stick in the groove, plaster accurately is affixed on the bilateral SHENYU point, give the TDP irradiation and sticked the position 30 minutes, stick lasting 6-8 hour, once a day, 15 days was 1 course for the treatment of, use 4 courses for the treatment of (Spring Equinox, the Summer Solstice, the Autumnal Equinox, Winter Solstice) every year, continuous application 3 years.Deficiency of the kidney yin the person paste with the deficiency of YIN; Whenever the Summer Solstice (the cloudy beginning gives birth in the Summer Solstice), all patients all paste deficiency of YIN subsides 3 days to rise the same day in the Summer Solstice.
The inventor is according to the experience of more than 30 years treatment chronic aplastic anemias, invented chronic aplastic anemia shen shu application therapy, this therapy is under the guidance of traditional Chinese medical science inner disease outer treat theory, for the chronic aplastic anemia etiology and pathogenesis, dialectically combine with differential diagnosis of diseases, select the medicine prescription take kidney tonifying, essence replenishing, blood-nourishing blood-generating as principle, theoretical in conjunction with tcm time medicine, meridional point is theoretical, select to treat between Winter Solstice and midsummer, give full play to the Comprehensive Treatment effect of chronotherapy, pharmacotherapy, acupoint therapy.By clinical observation, chronic aplastic anemia shen shu application therapy is safe and effective, and is cheap.
The side separates
1. the deficiency of YIN is pasted take Radix Rehmanniae Preparata, Colla Plastri Testudinis as monarch drug
The sweet tepor of Radix Rehmanniae Preparata enters Liver and kidney and the special nourishing the blood and yin of merit, and life essence-filling, marrow-benefitting is the key medicine of tonifying kidney-yin." medicineization justice " cloud: Radix Rehmanniae Preparata settling five organs, and blood vessels, the profit skin, nourishing the heart to keep a sound mind, peaceful soul, nourish Kidney-Yin, packing bone marrow, for panacea also. " the sweet Wen Zhirun of Radix Rehmanniae Preparata be described, the beneficial essence of nourishing YIN has the merit of the tonify deficiency of nourishing blood with hemopoietic.Colla Plastri Testudinis, salty in the mouth, sweet cold nature is returned liver, kidney, heart channel, has nourishing YIN for suppressing the hyperactive YANG, replenishing kidney and strengthening bone, an effect of the reinforcing the heart of nourishing blood." book on Chinese herbal medicine covers bamboo fish trap " records Carapax Et Plastrum Testudinis energy " specially nourishing YIN declines, and kind nourishing kidney is decreased "." Ling Shu Miraculous Pivot or Divine Axis carbuncle " cloud: " body fluid and accent, change and red be blood ".Illustrate that Colla Plastri Testudinis treats the cloudy all diseases of blood deficiency of losing by nourishing cloudy essence.
With Radix Angelicae Sinensis, Colla Corii Asini enriching yin and nourishing kidney, blood-nourishing blood-generating is ministerial drug altogether.Enrich blood with Pseudobulbus Bletillae (Rhizoma Bletillae), pseudo-ginseng blood-circulation-invigovating, promoting tissue regeneration by removing blood stasis, and help all medicine drug effects thoroughly to reach skin texture, be adjuvant altogether.All medicines share plays enriching yin and nourishing kidney altogether, and beneficial essence is filled out the merit of marrow, the treatment chronic aplastic anemia person that is partial to the deficiency of the kidney yin.
2. modern pharmacological research
Radix Rehmanniae Preparata: its main effective ingredient is prepared rehmannia root polysaccharide, this composition has the effect that promotes bone marrow hematogenesis and excited immunity, its mechanism may be by promoting to induce after the IL-1 secretion in the serum grain-huge to bite transcribing of fine colony stimulating factor, perhaps bite fine colony stimulating factor by promoting to induce after the IL-2 secretion T cell to produce grain-huge, grain-huge is bitten fine colony stimulating factor and can be kept hemopoietic forebody cell and mature erythrocyte (neutrophilic granulocyte, eosinophilic granulocyte and mononuclear phagocyte) survival, promote hemopoietic forebody cell (mononuclear cell, granulocyte and megalokaryocyte) proliferation and differentiation, strengthen the phagocytic function of neutrophilic granulocyte and macrophage.
The Colla Plastri Testudinis active component is various colloids, keratin, steroidal compounds and a small amount of trace element; it can leukocyte increasing, platelet, hemoglobin content; can also strengthen reticuloendothelial phagocytic function; improve the immunity of organisms infection control; in bleeding time due to the anemia, shortening wound, also has enhancing development; defying age, protection central nervous system's effect.
Radix Angelicae Sinensis: main component is volatile oil, organic acid, fructose, polysaccharide, vitamin etc.Its anti-anemia effect mainly is because Radix Angelicae Sinensis polysaccharide can stimulate the bone marrow macrophage in the hemopoietic inductive microenviroment, from gene and protein level secretion and the synthetic hematopoietic regulation factor, promote the proliferation and differentiation of polyphyly hemopoietic progenitor cell such as CFU-Mix, CFU-E, CFU-GM etc., stimulate bone marrow hematogenesis, wherein contained vitamin B12, nicotinic acid, folic acid, folinic acid is important hemopoietic raw material in the Radix Angelicae Sinensis.In addition, has the enhancing human body immunity function when giving back, antioxidation and remove free radical, the effects such as analgesia, antiinflammatory, antibiotic, radioprotective and anti-damage.
Colla Corii Asini: its pharmacological action is finished by common coordination of protein, aminoacid and trace element in the Colla Corii Asini, its anti-anemia effect mainly is to possess the allos inducing properties by donkey skin extracellular matrix composition contained in the Colla Corii Asini, it is by increasing hematopoietic progenitor colony BFU-E, CFU-E, CFU-GM, stimulate Liver and kidney EPO and GM-CSFmRNA to express, improve the content of peripheral blood GM-CSF, IL-6, EPO, reduce hemopoietic negative regulatory factor INF-γ, TGF-β content, play the effect that promotes bone marrow hematogenesis.Colla Corii Asini also has antitumor in addition, and blood vessel dilating improves immunity of organisms, promotes the effects such as absorption of calcium.
The Pseudobulbus Bletillae (Rhizoma Bletillae): active component is bibenzyl, luxuriant and rich with fragrance class and derivant thereof, and volatile oil, mannan, phlegmatic temperament and glucose etc. have hemostasis, antiulcer, antibiotic, antitumor, promotes wound healing, promotes the function of vascular endothelial cell growth.In addition, volatile oil is a kind of natural penetrating agent in this product, and the outer time spent can promote skin to absorption and the transmission of medicine.
Radix Notoginseng: its effective ingredient is the chemical compounds such as volatile oil, arasaponin, flavonoid glycoside, aminoacid, modern pharmacological research shows the multiple effects such as it has hemostasis, enriches blood, blood fat reducing, antiinflammatory, defying age, arrhythmia, wherein arasaponin can induce a plurality of transcription factor of hematopoietic cell such as GATA bunch, AP bunch, nuclear factor-KB etc. from the differentiation of gene level regulation and control hemopoietic progenitor cell, propagation, promote hemopoietic, improve anemia.Arasaponin, dencichine are by strengthening hematoblastic viscous yielding campaign simultaneously, and induced platelet discharges the styptic activity materials such as ADP, arachidonic acid, plays the effect that promotes blood coagulation.In addition, volatile oil is good penetrating agent, can promote the Transdermal absorption of medicine.
3. select the cave principle
Theoretical according to the Chinese medicine meridian acupuncture points on the human body, meridians are paths of human qi and blood running, and acupuncture points on the human body is that viscera QI of channels and collaterals blood infusion is in the privileged sites of body surface.Acupuncture points on the human body belongs to each passages through which vital energy circulates, and passages through which vital energy circulates is under the jurisdiction of specific internal organs, connects each other, refinforces each other between acupuncture points on the human body, passages through which vital energy circulates, the internal organs, consists of an indivisible integral body.Drug effect is in acupuncture points on the human body, by dredging the meridian, and concordant remedies gas, through the effect of gas, QI and blood regulating, Yin Yang balancing is to reach the purpose of preventing and curing diseases.SHENYU acupoint comes from " Ling Shu Miraculous Pivot or Divine Axis back of the body Yu " piece of writing, is the back shu points of kidney, belongs to bladder meridian.Under the 2nd spinous process of lumbar vertebra, 1.5 cun places are opened on the side.It is supporing yang to have kidney tonifying, receives the merit of gasified water, strengthening the body resistance.Cure mainly all diseases of suffering from a deficiency of the kidney.Back shu points is internal organs through the acupuncture point of gas infusion in back of the body waist, is " the information epitome " of internal organs, the exterior and the interior internal organs, affiliated histoorgan.Because of bladder meridian and kidney meridian phase the exterior and the interior, and waist is house of kidney, and the kidney generating marrow and dominating bone is chosen shen shu and sticked, and medicine can be directly acted on kidney, plays kidney tonifying marrow facilitating, the effect of spermatogenesis blood.
4. application time is selected
According to the chronic aplastic anemia pathogen and pathology of tcm in conjunction with tcm time medicine thought really.Tcm time medicine thought thinks that man and nature are unified, and there are synchronicity in people's the vital movement rhythm and pace of moving things and the variation of natural cycle.Its root of chronic aplastic anemia negative and positive of qi and blood virtual loss due to suffer from a deficiency of the kidney with the passing of time." interior warp " cloud: " kidney person master sting, the dominator of storing essence, smart part also is shaoyin within yin, leads in winter gas "." Plain Questions. opinion during the visceral-qi method " propose: " sick at kidney, more in the spring, the spring does not heal, and is far more than the long summer, and the long summer is not dead, is held in the autumn, arises from the winter." illustrate that kidney belongs to the winter, the main Tibetan, winter, human body was accumulated in kidney, this moment, the yang-energy of kidney was the most prosperous; if yang-energy is when prosperous in the kidney, winter, it was cold, cold tending to injure YANG; then can feel evil morbidity or increase the weight of the state of an illness, so chronic aplastic anemia patient aggravation in winter, especially take yang deficiency person relatively as even.And summer the human body kidney the moon smart abundant, if cloudy damage of essence is empty, it thermal burn is cloudy, then can increase the weight of the state of an illness, so chronic aplastic anemia patient yin asthenia generating intrinsic heat in summer symptom is obvious, especially to be partial to deficiency of YIN person for very.According to Changing Pattern free period, be in the summersolstice the annual Summer Solstice, and we propose the theory of " nourishing YIN in the Summer Solstice ".Whenever the Summer Solstice, all patients all stick deficiency of YIN subsides three days to rise the same day in the Summer Solstice, and giving treatment in accordance with the tendency of pathological change is strengthened kidney invigorating and YANG supporting, the effect of YIN nourishing benefit marrow.On ordinary days partially decline according to the patient is yin or yang excess, give to stick accordingly agent.
Patent of the present invention has easy to use, good effect, the advantage such as side effect is little.
The specific embodiment
Embodiment one
Treating the medicine that sticks of chronic aplastic anemia, is to paste ingredients by the deficiency of YIN.
The deficiency of YIN is pasted medicine, is to be prepared into by Radix Rehmanniae Preparata 30g, Colla Plastri Testudinis 30g, Radix Angelicae Sinensis 15g, Colla Corii Asini 15g, Radix Notoginseng 5g and Pseudobulbus Bletillae (Rhizoma Bletillae) 5g.
Embodiment two
Treating the medicine that sticks of chronic aplastic anemia, is to paste ingredients by the deficiency of YIN.
The deficiency of YIN is pasted medicine, is to be prepared into by Radix Rehmanniae Preparata 25g, Colla Plastri Testudinis 25g, Radix Angelicae Sinensis 10g, Colla Corii Asini 10g, Radix Notoginseng 3g and Pseudobulbus Bletillae (Rhizoma Bletillae) 5g.
Embodiment three
Treating the medicine that sticks of chronic aplastic anemia, is to paste ingredients by the deficiency of YIN.
The deficiency of YIN is pasted medicine, is to be prepared into by Radix Rehmanniae Preparata 35g, Colla Plastri Testudinis 35g, Radix Angelicae Sinensis 20g, Colla Corii Asini 20g, Radix Notoginseng 6g and Pseudobulbus Bletillae (Rhizoma Bletillae) 3g.
Claims (3)
1. treat the medicine that sticks of chronic aplastic anemia, it is characterized in that pasting ingredients by the deficiency of YIN;
The deficiency of YIN is pasted medicine, is to be prepared into by Radix Rehmanniae Preparata 25-35g, Colla Plastri Testudinis 25-35g, Radix Angelicae Sinensis 10-20g, Colla Corii Asini 10-20g, Radix Notoginseng 3-6g and Pseudobulbus Bletillae (Rhizoma Bletillae) 3-6g.
Treatment chronic aplastic anemia according to claim 1 stick medicine, it is characterized in that pasting ingredients by the deficiency of YIN;
The deficiency of YIN is pasted medicine, is to be prepared into by Radix Rehmanniae Preparata 30g, Colla Plastri Testudinis 30g, Radix Angelicae Sinensis 15g, Colla Corii Asini 15g, Radix Notoginseng 5g and Pseudobulbus Bletillae (Rhizoma Bletillae) 5g.
3. the preparation method that sticks medicine for the treatment of chronic aplastic anemia according to claim 1 is characterized in that comprising the steps:
(1) get the raw materials ready:
Get Radix Rehmanniae Preparata, Colla Plastri Testudinis, Radix Angelicae Sinensis, Colla Corii Asini, Radix Notoginseng and the Pseudobulbus Bletillae (Rhizoma Bletillae), oven dry is ground into fine powder respectively, crosses 200 mesh sieves, and splendid attire is for subsequent use respectively;
(2) the preparation deficiency of YIN is pasted medicine:
Get Radix Rehmanniae Preparata powder 25-35g, Carapax Et Plastrum Testudinis rubber powder 25-35g, Radix Angelicae Sinensis powder 10-20g, Colla Corii Asini powder 10-20g, Radix Notoginseng powder 3-6g and Pseudobulbus Bletillae (Rhizoma Bletillae) powder 3-6g, it is even to be mixed, and get final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104000942A (en) * | 2014-05-18 | 2014-08-27 | 陈洪佳 | Mixed traditional Chinese medicine for treating aplastic anemia |
| CN104524254A (en) * | 2014-12-08 | 2015-04-22 | 吕凤荣 | Qi failing to control blood type "aplastic anemia" spleen tonifying and kidney invigorating preparation and preparation method thereof |
| CN104544046A (en) * | 2014-12-11 | 2015-04-29 | 泰州市古月楼餐饮有限公司 | Women soup dumpling filling and manufacturing method of women soup dumpling |
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| CN1137393A (en) * | 1995-06-08 | 1996-12-11 | 孟涛 | Yisuishengxue Chinese medicine preparation for tonifying marrow and promoting generation of blood |
| CN1840006A (en) * | 2006-01-26 | 2006-10-04 | 周伟 | Medicine for treating aplastic anemia |
| CN101391056A (en) * | 2008-10-23 | 2009-03-25 | 王湛 | Medicine for treating aplastic anemia |
| CN102205051A (en) * | 2011-05-20 | 2011-10-05 | 韩丹艳 | Notoginseng root hematogenic medicament and preparation method thereof |
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2013
- 2013-01-08 CN CN201310004703.7A patent/CN103055147B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1137393A (en) * | 1995-06-08 | 1996-12-11 | 孟涛 | Yisuishengxue Chinese medicine preparation for tonifying marrow and promoting generation of blood |
| CN1840006A (en) * | 2006-01-26 | 2006-10-04 | 周伟 | Medicine for treating aplastic anemia |
| CN101391056A (en) * | 2008-10-23 | 2009-03-25 | 王湛 | Medicine for treating aplastic anemia |
| CN102205051A (en) * | 2011-05-20 | 2011-10-05 | 韩丹艳 | Notoginseng root hematogenic medicament and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104000942A (en) * | 2014-05-18 | 2014-08-27 | 陈洪佳 | Mixed traditional Chinese medicine for treating aplastic anemia |
| CN104524254A (en) * | 2014-12-08 | 2015-04-22 | 吕凤荣 | Qi failing to control blood type "aplastic anemia" spleen tonifying and kidney invigorating preparation and preparation method thereof |
| CN104544046A (en) * | 2014-12-11 | 2015-04-29 | 泰州市古月楼餐饮有限公司 | Women soup dumpling filling and manufacturing method of women soup dumpling |
| CN104544046B (en) * | 2014-12-11 | 2016-12-07 | 江苏古月楼餐饮有限公司 | A kind of woman's steamed dumping stuffing material and the manufacture method of woman's steamed dumping |
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