CN102648950A - Traditional Chinese medicinal composition for eliminating body fatigue and movement disorder and relieving pains - Google Patents
Traditional Chinese medicinal composition for eliminating body fatigue and movement disorder and relieving pains Download PDFInfo
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- CN102648950A CN102648950A CN201210126076XA CN201210126076A CN102648950A CN 102648950 A CN102648950 A CN 102648950A CN 201210126076X A CN201210126076X A CN 201210126076XA CN 201210126076 A CN201210126076 A CN 201210126076A CN 102648950 A CN102648950 A CN 102648950A
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Abstract
The invention discloses a traditional Chinese medicinal composition for eliminating body fatigue and movement disorder and relieving pains. The medicinal composition is prepared from 19 Chinese herbs such as phryma leptostachya, prepared monkshood, radix clematidis, and impatiens balsamina. The traditional Chinese medicinal composition has good therapeutic effects of eliminating the body fatigue and the movement disorder and relieving the pains, can relieve the pains and eliminate inflammation quickly, promotes blood circulation and recover from fatigue; and generally, symptoms are significantly reduced after half an hour.
Description
Technical field
The present invention relates to a kind of allaying tiredness and the dyskinesia, lenitive Chinese medicine composition, belong to technical field of Chinese medicine.
Background technology
Fatigue is a kind of subjective uncomfortable sensation, but objectively can under equal conditions lose it and accomplish original normal activity of being engaged in or ability to work, and along with the development of society, rhythm of life is accelerated, and operating pressure strengthens, and usually is in a kind of fatigue state; As the athlete, usually tired unusually in addition at high-intensity training lower limb body, produce the dyskinesia.As far back as 1880, Mosso (Mosso) the human fatigue that just begins one's study.After this, many famous scholars adopt the means of different broad research tired from multiple visual angle, and successively give tired different concept.Modern Chinese medicine thinks, fatigue is due to the deficiency syndrome and mental change (or not smooth) double factor of first QI consumed wound.Not only want tonify deficiency to set upright in the treatment, tired the calming the nerves of also should dispelling.On the one hand, the tonify deficiency primordial QI reinforcing nourishes body, empty must the benefit, and canonical is prosperous, and is tired from removing; On the other hand, transfer smooth will, comfortable smooth meaning, refreshing must the peace, the heart is then peaceful, and fatigue can disappear.
Participate in physical training and training and match, time to a certain degree, human body will produce the temporarily-depressed phenomenon of ability to work, and this phenomenon is called sports fatigue.Mainly show three aspects: muscle fatigue: muscle strength descends, and contraction speed slows down, and that muscle occurs is stiff, swelling and pain, slow motion, inharmonious; Neural fatigue: bradykinesia, misjudge, absent minded; Internal organs are tired: breathing shoals accelerates palpitating speed etc.
Sports fatigue belongs to " the power labor " in the theory of Chinese medical science, deficiency syndrome should be treated by tonifying method, and the traditional Chinese medical science is many to be controlled from the spleen reinforcing opinion.Spleen is " the foundation of acquired constitution ", source of generating QI and blood.The material consumption of motor process depends on the source of the gas source that the battalion of the fortune generation of spleen defends and constantly replenishes, and keeping the qi-blood-body fluid that motion is consumed, and promotes the recovery after the fatigue.Spleen governing limbs muscle is participated in motion directly.Receiving of taste is normal, and then essence derived from food is from prosperous, and the change source is no lack of, limb muscle be replenishing vital QI with drugs of warm nature.Motion must rely giving full play to of limb muscle normal function; And the healthy and strong abundant and limbs of muscle is strong and vigorous flexibly, depends on the healthy and vigorous of temper, and fortuneization is normal.
Because quantity of motion is different, the fatigue of generation also has branch in various degree.Generally fatigue is divided into three levels: slight, moderate and very tired.Slight fatigue can be eliminated at short notice; Moderate fatigue also can be eliminated through taking a series of means very soon, can not influence health; If but severe fatigue can not in time eliminate, will interfere with one's studies and live the damage health.Using Chinese medicine, like the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Radix Notoginseng etc., all is that the function of regulating the central nervous system is arranged, and the effect of the strong muscle of coronary artery dilator and QI invigorating has effect preferably to promoting tired elimination.
Pain is the symptom of multiple disease, and it makes the patient experience painful, and especially severe pain possibly cause that also physiological function is disorderly, even shock.Aching pain of muscles has two kinds: a kind of is to occur ache immediately after the motion, but it is also very fast to disappear, and is called acute aching pain of muscles; Another kind is not that immediate postexercise produces ache, even but the just appearance several hours nights of sleeping after after motion disappears also very slowly, couple of days to disappear.This ache is called the retardance aching pain of muscles.
Acute aching pain of muscles usually is that the oxygen supply is not gone up, and causes lactic acid bulk deposition in the muscle because motion is too violent.Lactic acid is a kind of acidic materials, and the nerve in can stimulated muscle is the tip not, produces pain perception; In addition, lactic acid is deposited in and can causes the local penetration pressure excessive in the muscle, will inhale moisture content on every side like this and come, and causes the muscle edema; The stimulation of this swelling also is the reason that causes aching pain of muscles; The retardance aching pain of muscles thinks that main muscle fiber has a spot of tear or the connective tissue of muscle has certain damage to cause behind prolonged exercise.
Therefore, suitably the drug application alleviating pain prevents that issuable physiological function disorder from being very necessary.Lenitive medicine by its pharmacological action and mechanism of action, can be divided into two big types: the first mainly acts on the central nervous system, optionally eliminates or alleviate the medicine of the pain sensation; When analgesia, Consciousness, other feel unaffected; This type medicine is called analgesic (analgesics); Like opiates, be used for severe pain more, be easy to addiction but use repeatedly; It two is the medicines with analgesia, analgesic, antiinflammatory action, and is effective to various dull pains (like headache, toothache etc.), like ibuprofen, dexamethasone etc.
Present some chemosynthesis class medicines on the market, to eliminating fatigue, improving sports achievement, alleviating pain has the effect of short time, but it has bigger side effect to human body.Therefore, no matter be the fatigue and the dyskinesia that work or motion produce, it is little all to press for a kind of side effect, can eliminate limbs fatigue, the dyskinesia and lenitive pure Chinese medicinal preparation fast.
Summary of the invention
The inventor is based on drug world working experience for many years, and experiment many times and exploration, successfully develops the present invention finally.
The purpose of this invention is to provide elimination limbs tired and the dyskinesia and lenitive Chinese medicine composition that a kind of pure Chinese medicine is processed.
Another object of the present invention is to provide the method for preparing of above-mentioned Chinese medicine composition.
For achieving the above object, the present invention has adopted following technical scheme:
A kind of elimination limbs tired and the dyskinesia and lenitive Chinese medicine composition, calculate according to components by weight percent: be to be processed by the effective raw material and the pharmaceutic adjuvant of following weight proportion:
Herba speranskiae tuberculatae 70-130 part; Radix Aconiti Preparata 31.5-58.5 part; Radix Clematidis 49-91 part; Flos Impatientis 49-91 part; Radix Aconiti Kusnezoffii 31.5-58.5 part; Stigma Croci 31.5-58.5 part; Herba Aristolochiae Mollissimae 49-91 part; Radix Angelicae Pubescentis 31.5-58.5 part; Radix Notoginseng 31.5-58.5 part; Radix Angelicae Dahuricae 49-91 part; Radix Aucklandiae 33.6-62.4 part; Windproof 33.6-62.4 part; Herba Schizonepetae 33.6-62.4 part; Herba Asari 33.6-62.4 part; Ramulus Cinnamomi 33.6-62.4 part; Radix Achyranthis Bidentatae 33.6-62.4 part; Herba Lycopi 33.6-62.4 part; Borneolum Syntheticum 10.5-19.5 part; Camphora 38.5-71.5 part.
Specifically, said elimination limbs tired and the dyskinesia and lenitive Chinese medicine composition, calculate according to components by weight percent: be to be processed by the effective raw material and the pharmaceutic adjuvant of following weight proportion:
Herba speranskiae tuberculatae 80-120 part, Radix Aconiti Preparata 36-54 part, Radix Clematidis 56-84 part, Flos Impatientis 56-84 part, Radix Aconiti Kusnezoffii 36-54 part, Stigma Croci 36-54 part, Herba Aristolochiae Mollissimae 56-84 part, Radix Angelicae Pubescentis 36-54 part, Radix Notoginseng 36-54 part, Radix Angelicae Dahuricae 56-84 part, Radix Aucklandiae 38.4-57.6 part, windproof 38.4-57.6 part, Herba Schizonepetae 38.4-57.6 part, Herba Asari 38.4-57.6 part, Ramulus Cinnamomi 38.4-57.6 part, Radix Achyranthis Bidentatae 38.4-57.6 part, Herba Lycopi 38.4-57.6 part, Borneolum Syntheticum 12-18 part, Camphora 44-66 part.
The present invention can also further realize through following optimal technical scheme:
Said elimination limbs tired and the dyskinesia and lenitive Chinese medicine composition, calculate according to components by weight percent: be to be processed by the effective raw material and the pharmaceutic adjuvant of following weight proportion:
100 parts of Herba speranskiae tuberculataes, 45 parts of Radix Aconiti Preparatas, 70 parts of Radix Clematidis, 70 parts of Flos Impatientiss, 45 parts of Radix Aconiti Kusnezoffii, 45 parts of Stigma Crocis, 70 parts of Herba Aristolochiae Mollissimaes, 45 parts of Radix Angelicae Pubescentiss, 45 parts of Radix Notoginseng, 70 parts of the Radixs Angelicae Dahuricae, 48 parts of the Radix Aucklandiae, windproof 48 parts, Herba Schizonepetae 48,48 parts of Herba Asaris, 48 parts of Ramulus Cinnamomi, 48 parts of Radix Achyranthis Bidentataes, 48 parts of Herba Lycopi, 15 parts of Borneolum Syntheticums, 55 parts of Camphoras.
Chinese medicine composition of the present invention is to be principal agent with dispel the wind cold-damp medicine Herba speranskiae tuberculatae, Radix Clematidis, Flos Impatientis, Herba Aristolochiae Mollissimae, Radix Angelicae Pubescentis and Radix Aconiti Radix Aconiti Kusnezoffii, and Herba speranskiae tuberculatae and Flos Impatientis dispel the wind, invigorate blood circulation, reducing swelling and alleviating pain; The Radix Clematidis expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, Herba Aristolochiae Mollissimae dispelling wind and removing obstruction in the collateral, pain relieving; Radix Angelicae Pubescentis expelling wind and dampness, dispersing cold for relieving pain, Radix Aconiti Radix Aconiti Kusnezoffii expelling wind and removing dampness, antalgic, cold expelling detumescence, each medicine improves blood circulation jointly; Pain and detumescence due to the elimination exercise fatigue, alleviation fatigue; Collocation wind-cold-dispersing medicinal Ramulus Cinnamomi, Herba Schizonepetae, windproof, the Radix Angelicae Dahuricae and Herba Asari play the effect of dispersing wind and cold, bone and muscle strengthening; Be aided with pseudo-ginseng blood-circulation-invigovating collateral dredging, removing stasis to stop bleeding in addition, Flos Carthami and Herba Lycopi's promoting blood flow to regulate menstruation, Radix Achyranthis Bidentatae inducing diuresis for treating stranguria syndrome, eliminating blood stasis and inducing menstruation had both been strengthened the merit of pseudo-ginseng blood-circulation-invigovating collateral dredging, helped QI and bloodization again and gave birth to, and eliminated the limbs fatigue and the dyskinesia; The Radix Aucklandiae is regulated the flow of vital energy, Borneolum Syntheticum is had one's ideas straightened out, the Camphora counteracting toxic substances is antipruritic, helps refreshment, the pleasant poison of dispelling.Above-mentioned each medicine is played the effect of blood circulation promoting and blood stasis dispelling, collateral dredging QI invigorating, consciousness and resuscitation restoring, reducing swelling and alleviating pain altogether, is very beneficial for eliminating the limbs fatigue and the dyskinesia, alleviating pain.
Chinese medicine composition of the present invention can be processed external preparation such as spray, tincture, patch, also can process oral formulations such as oral liquid, tablet, capsule or granule.
The above-mentioned elimination limbs fatigue and the dyskinesia and lenitive Chinese medicinal composition preparation can be prepared from through following method:
Except that Camphora, Borneolum Syntheticum, all the other Herba speranskiae tuberculataes etc. 17 flavor is ground into coarse powder, makes solvent with 45-70% ethanol, flood 24-60 hour or reflux, extract, 2-3 time, and merging filtrate filters, collection medicinal liquid, other device preservation; After getting ethanol that Camphora, Borneolum Syntheticum adds medicinal liquid weight 11%-15% and making dissolving,, be prepared into various required preparations according to conventional method with above-mentioned medicinal liquid mixing.
The elimination limbs fatigue according to the invention and the dyskinesia and lenitive Chinese medicinal composition preparation also can be prepared from through following method:
Take by weighing medicine in proportion, except that Camphora, Borneolum Syntheticum, 17 flavors such as all the other Herba speranskiae tuberculataes are ground into coarse powder, add 6-10 times of water gaging and decoct extraction 2-3 time; Each 1-3 hour, extracting solution merged, and filtered, and filtrating concentrates; To filtrate under agitation adds ethanol and makes the alcohol amount of containing be 50-70%, leaves standstill 12-24 hour, filters; Camphorate, Borneolum Syntheticum, mixing is processed various required preparations according to conventional method.
Below through the present composition is being eliminated the limbs fatigue and the dyskinesia, the Pharmacodynamic test of active extract example that alleviating pain does to use further sets forth the beneficial effect of medicine according to the invention:
One, the research of present composition removing blood stasis to reduce swelling effect
1. to the influence of the traumatic ecchymosis of rat
Divide into groups and administration: get 50 of SD rats, body weight 180-200g, the male and female dual-purpose is divided into blank group, analgesia collaterals-activating tincture positive controls, the high, medium and low dose groups of extract of the present invention at random.Extract wherein of the present invention adopts the arbitrary method of embodiment 1-8 to prepare.Experiment is lost hair or feathers rat back the previous day with 8% sodium sulfide, use vice bark pocket skin then, causes subcutaneous hemorrhage (area 4 * 4cm
2), ecchymosis appears after one hour, be applied to the ecchymosis place equably with being about to medicinal liquid, observe the ecchymosis situation that disappears every day every day twice, and the result sees table 1.
The influence of the table 1 pair traumatic ecchymosis of rat (x ± s, n=10)
| Group | Number of animals (only) | Dosage (the g crude drug/kg) | The ecchymosis natural law that disappears |
| Blank | 10 | -- | 8.2±1.1 |
| The analgesia collaterals-activating tincture | 10 | 2ml | 6.6±1.3** |
| Extract of the present invention | 10 | 0.43 | 6.8±1.2*△ |
| Extract of the present invention | 10 | 0.86 | 6.3±1.1**△ |
| Extract of the present invention | 10 | 1.72 | 6.0±1.2**△ |
Annotate: compare * P＜0.05, * * P＜0.01 with blank control group; Compare △ P＞0.05 with positive controls.
2. the research that mice blood stasis model ecchymosis is absorbed
Divide into groups and administration: 50 mices will processing subcutaneous ecchymosis model are divided into 5 groups at random, i.e. blank group, analgesia collaterals-activating tincture positive controls, the high, medium and low dose groups of extract of the present invention.Extract wherein of the present invention adopts the arbitrary method of embodiment 1-8 to prepare.After 4 hours, administration immediately behind the mensuration ecchymosis area, every day is coating on ecchymosis, and one day twice, continuous 7 days.Measure the ecchymosis area every day once, the ecchymosis area of ecchymosis extinction time and 1-3 days relatively, the result sees table 2.
The research that the subcutaneous ecchymosis of table 2 pair mice absorbs (x ± s, n=10)
Annotate: compare * P＜0.05, * * P＜0.01 with blank control group; Compare △ P＞0.05 with positive controls.
The result can find out that the present composition can promote the subcutaneous ecchymosis of mice to absorb; Significantly reduce the ecchymosis area and shorten its extinction time; And can shorten the traumatic ecchymosis regression time of rat; The prompting present composition can obviously alleviate the symptoms such as swelling pain that soft tissue injury or osteoarthritis cause, reaches blood circulation promoting and blood stasis dispelling, the effect of anti-inflammatory analgetic.
Two, alleviate the tired and dyskinetic research of limbs
1. to the influence of mice swimming time
Get 72 of NIH mices, male and female half and half, body weight 18-22g, mice swimming time test method is undertaken by document record routine, and the result sees table 3.
The influence of table 3 pair mice swimming time (x ± s, n=10)
| Group | Number of animals (only) | Dosage (the g crude drug/kg) | Swimming time (second) |
| Blank | 12 | -- | 488.2±71.3 |
| The analgesia collaterals-activating tincture | 12 | 5ml | 538.6±63.1 |
| Bone-setting liquor | 12 | 10ml | 536.3±51.3* |
| Extract of the present invention | 12 | 0.43 | 526.4±45.2*△ |
| Extract of the present invention | 12 | 0.86 | 547.1±44.8*△ |
| Extract of the present invention | 12 | 1.72 | 562.0±51.7*△ |
Annotate: compare * P＜0.05 with blank control group; Compare △ P＞0.05 with positive controls.
2. to the influence of mice coordination exercise ability and endurance
Get 90 of NIH mices; Male and female half and half; Body weight 18-22g, with rotating rods method observe (rotating speed 12 changes/min), select for use 60 of animals that stop on the rod more than the 3min; Be divided into 5 groups at random, i.e. normal saline blank group, analgesia collaterals-activating tincture positive controls, the high, medium and low dose groups of extract of the present invention.Medication every day 1 time, blank group be with the substrate of equivalent, and continuous 7 days, after the last administration 1 hour, measure in the 5min by rotating rods method and respectively to organize the number of times that mice falls from rod, the result sees table 4.
Table 4 present composition is to the influence of the mice coordination ability and endurance (x ± s)
| Group | Number of animals (only) | Dosage (the g crude drug/kg) | Drop number (5min) |
| Blank | 12 | -- | 4.2±1.5 |
| Bone-setting liquor | 12 | 10ml | 2.6±1.3* |
| Extract of the present invention | 12 | 0.43 | 2.8±1.0*△ |
| Extract of the present invention | 12 | 0.86 | 2.5±0.8**△ |
| Extract of the present invention | 12 | 1.72 | 2.2±1.1**△ |
Annotate: compare * P＜0.05, * * P＜0.01 with blank control group; Compare △ P＞0.05 with positive controls.
Above-mentioned experiment shows that the present composition obviously improves the swimming exercise ability of mice, has significantly reduced the number of times that mice falls from rod, and the prompting present composition can be eliminated exercise fatigue, improves sports coordination ability and continuous capability.
Three, the athlete tests to pedal
3.1 subjects: select for use certain basket baller of colleges and universities to be subjects, each 10 of men and women, mean age 19.76 ± 1.42, the training time limit 4.51 ± 0.64, height 185 ± 3.24, body weight 68.34 ± 7.23.
3.2 instrument: adopt yueyang, hunan to produce the luxury treadmill formula of EGM-IV heart merit amount machine.
3.3 test method: the experimenter rides on car, zero load at full speed treadmill 5s as warm up, rest 2min; Treadmill increases load and in 2-4s, reaches 300W (women 275W) to 60rpm then, behind 300W, makes experimenter's treadmill at full speed immediately; Write down it respectively at 0-5s; Total revolution in 10s, 20s, the treadmill revolution of four time periods of 30s (every section 5s) and the 30s after the off-test, loosens and rides 2-3min.
Receive once to measure before the reagent, give continuously and received the reagent thing in 7 days, carry out the mensuration of same procedure once more.Receive the reagent thing to be the spray of the embodiment of the invention 9 preparations, 2 times on the one, once an amount of.
3.4 the record of heart rate before and after the motion: adopt CC5 to lead, signal is imported 6511 type electrocardiograph recorded heart rate, imports the oscillograph direct-view of SR12A type two wires simultaneously.Write down the experimenter respectively when quiet (riding on Power Vehicle), at once heart rate after the 30s test.
3.5 the gained data are all through statistical disposition, the result is with expression, and significance test of difference adopts the t check.
3.6 result:
The result compares before and after showing the medication of men and women basket baller treadmill speed sum, and the present composition can increase the total revolution of athlete's treadmill, and heart rate also had significant change after medication seesawed, and increased the athlete heart reserve capabillity; The pain that can also obviously alleviate acute muscle in addition with slow down the persistent period of aching.Point out this compositions to have the effect that improves athlete's resisting fatigue, improves sports achievement and slow down limbs pain.The result is like table 5,6, shown in 7.
The treadmill revolution of different time sections during table 5 team member 30s test
The variation (b/min) of heart rate before and after the table 6 team member 30s test
| Group | n | When quiet | After the 30s motion |
| The medicine man | 10 | 65.37±6.46 | 159.64±11.42 |
| Preceding woman | 10 | 67.54±6.18 | 162.78±12.53 |
| The medicine man | 10 | 63.17±5.25 | 137.14±12.57** |
| The back woman | 10 | 64.12±6.33 | 142.68±13.29** |
Acute myalgia situation compared with the persistent period of aching before and after table 7 test
| Group | n | The myalgia number | Persistent period (min) |
| The medicine man | 10 | 8 | 4.83±0.47 |
| Preceding woman | 10 | 9 | 5.36±0.39 |
| The medicine man | 10 | 6 | 3.12±0.33** |
| The back woman | 10 | 6 | 4.06±0.35** |
Chinese medicine composition of the present invention proves through zoopery and human experimentation, and for eliminating the limbs fatigue and the dyskinesia, alleviating pain has good efficacy, can quickly alleviating pain, antiinflammatory, blood circulation promoting and blood stasis dispelling, set up, and effect is remarkable, has no side effect.
The specific embodiment
Do bright specifically below in conjunction with implementing to the present invention.
Embodiment 1:
Herba speranskiae tuberculatae 100g, Radix Aconiti Preparata 45g, Radix Clematidis 70g, Flos Impatientis 70g, Radix Aconiti Kusnezoffii 45g, Stigma Croci 45g, Herba Aristolochiae Mollissimae 70g, Radix Angelicae Pubescentis 45g, Radix Notoginseng 45g, Radix Angelicae Dahuricae 70g, Radix Aucklandiae 48g, windproof 48g, Herba Schizonepetae 48g, Herba Asari 48g, Ramulus Cinnamomi 48g, Radix Achyranthis Bidentatae 48g, Herba Lycopi 48g, Borneolum Syntheticum 15g, Camphora 55g.
Except that Camphora, Borneolum Syntheticum, 17 flavors such as all the other Herba speranskiae tuberculataes are ground into coarse powder, make solvent with 53% ethanol, flood after 48 hours, filter, and collect medicinal liquid, and device is preserved in addition; Get the ethanol that Camphora, Borneolum Syntheticum add medicinal liquid weight 13.2%, make dissolving after, with above-mentioned medicinal liquid mixing, promptly get drug extract.
Embodiment 2:
Herba speranskiae tuberculatae 90g, Radix Aconiti Preparata 40.5g, Radix Clematidis 63g, Flos Impatientis 63g, Radix Aconiti Kusnezoffii 40.5g, Stigma Croci 40.5g, Herba Aristolochiae Mollissimae 63g, Radix Angelicae Pubescentis 40.5g, Radix Notoginseng 40.5g, Radix Angelicae Dahuricae 63g, Radix Aucklandiae 43.2g, windproof 43.2g, Herba Schizonepetae 43.2g, Herba Asari 43.2g, Ramulus Cinnamomi 43.2g, Radix Achyranthis Bidentatae 43.2g, Herba Lycopi 43.2g, Borneolum Syntheticum 13.5g, Camphora 49.5g.
Except that Camphora, Borneolum Syntheticum, 17 flavors such as all the other Herba speranskiae tuberculataes are ground into coarse powder, make solvent with 70% ethanol, flood after 24 hours, filter, and collect medicinal liquid, and device is preserved in addition; After getting ethanol that Camphora, Borneolum Syntheticum adds medicinal liquid weight 11% and making dissolving,, promptly get drug extract with above-mentioned medicinal liquid mixing.
Embodiment 3:
Herba speranskiae tuberculatae 110g, Radix Aconiti Preparata 49.5g, Radix Clematidis 77g, Flos Impatientis 77g, Radix Aconiti Kusnezoffii 49.5g, Stigma Croci 49.5g, Herba Aristolochiae Mollissimae 77g, Radix Angelicae Pubescentis 49.5g, Radix Notoginseng 49.5g, Radix Angelicae Dahuricae 77g, Radix Aucklandiae 52.8g, windproof 52.8g, Herba Schizonepetae 52.8g, Herba Asari 52.8g, Ramulus Cinnamomi 52.8g, Radix Achyranthis Bidentatae 52.8g, Herba Lycopi 52.8g, Borneolum Syntheticum 52.8g, Camphora 52.8g.
Except that Camphora, Borneolum Syntheticum, 17 flavors such as all the other Herba speranskiae tuberculataes are ground into coarse powder, make solvent with 45% ethanol, flood after 60 hours, filter, and collect medicinal liquid, and device is preserved in addition; After getting ethanol that Camphora, Borneolum Syntheticum adds medicinal liquid weight 15% and making dissolving,, promptly get drug extract with above-mentioned medicinal liquid mixing.
Embodiment 4:
Herba speranskiae tuberculatae 70g, Radix Aconiti Preparata 31.5g, Radix Clematidis 49g, Flos Impatientis 49g, Radix Aconiti Kusnezoffii 31.5g, Stigma Croci 31.5g, Herba Aristolochiae Mollissimae 49g, Radix Angelicae Pubescentis 31.5g, Radix Notoginseng 31.5g, Radix Angelicae Dahuricae 49g, Radix Aucklandiae 33.6g, windproof 33.6g, Herba Schizonepetae 33.6g, Herba Asari 33.64g, Ramulus Cinnamomi 33.6g, Radix Achyranthis Bidentatae 33.6g, Herba Lycopi 33.6g, Borneolum Syntheticum 10.5g, Camphora 38.5g.
Method for preparing: take by weighing medicine in proportion, except that Camphora, Borneolum Syntheticum, 17 flavors such as all the other Herba speranskiae tuberculataes are ground into coarse powder, add 6 times of water gagings and decoct extraction 3 times; Each 1 hour, extracting solution merged, and filtered, and filtrating concentrates; Under agitation add ethanol and make that to contain alcohol amount be 50%, left standstill 24 hours, filter; Filtrating camphorates, Borneolum Syntheticum, and mixing promptly gets drug extract.
Embodiment 5:
Herba speranskiae tuberculatae 130g, Radix Aconiti Preparata 58.5g, Radix Clematidis 91g, Flos Impatientis 91g, Radix Aconiti Kusnezoffii 58.5g, Stigma Croci 58.5g, Herba Aristolochiae Mollissimae 91g, Radix Angelicae Pubescentis 58.5g, Radix Notoginseng 58.5g, Radix Angelicae Dahuricae 91g, Radix Aucklandiae 62.4g, windproof 62.4g, Herba Schizonepetae 62.4g, Herba Asari 62.4g, Ramulus Cinnamomi 62.4g, Radix Achyranthis Bidentatae 62.4g, Herba Lycopi 62.4g, Borneolum Syntheticum 19.5g, Camphora 71.5g.
Take by weighing medicine in proportion, except that Camphora, Borneolum Syntheticum, 17 flavors such as all the other Herba speranskiae tuberculataes are ground into coarse powder, add 10 times of water gagings and decoct extraction 2 times; Each 3 hours, extracting solution merged, and filtered, and filtrating concentrates; Under agitation add ethanol and make that to contain alcohol amount be 70%, left standstill 12 hours, filter; Filtrating camphorates, Borneolum Syntheticum, and mixing promptly gets drug extract.
Embodiment 6:
Herba speranskiae tuberculatae 80g, Radix Aconiti Preparata 36g, Radix Clematidis 56g, Flos Impatientis 56g, Radix Aconiti Kusnezoffii 36g, Stigma Croci 36g, Herba Aristolochiae Mollissimae 56g, Radix Angelicae Pubescentis 36g, Radix Notoginseng 36g, Radix Angelicae Dahuricae 56g, Radix Aucklandiae 38.4g, windproof 38.4g, Herba Schizonepetae 38.4g, Herba Asari 38.4g, Ramulus Cinnamomi 38.4g, Radix Achyranthis Bidentatae 38.4g, Herba Lycopi 38.4g, Borneolum Syntheticum 12g, Camphora 44g.
Take by weighing medicine in proportion, except that Camphora, Borneolum Syntheticum, 17 flavors such as all the other Herba speranskiae tuberculataes are ground into coarse powder, add 8 times of water gagings and decoct extraction 2 times; Each 2 hours, extracting solution merged, and filtered, and filtrating concentrates; Under agitation add ethanol and make that to contain alcohol amount be 60%, left standstill 24 hours, filter; Filtrating camphorates, Borneolum Syntheticum, and mixing promptly gets drug extract.
Embodiment 7:
Herba speranskiae tuberculatae 120g, Radix Aconiti Preparata 54g, Radix Clematidis 84g, Flos Impatientis 84g, Radix Aconiti Kusnezoffii 54g, Stigma Croci 54g, Herba Aristolochiae Mollissimae 84g, Radix Angelicae Pubescentis 54g, Radix Notoginseng 54g, Radix Angelicae Dahuricae 84g, Radix Aucklandiae 57.6g, windproof 57.6g, Herba Schizonepetae 57.6g, Herba Asari 57.6g, Ramulus Cinnamomi 57.6g, Radix Achyranthis Bidentatae 57.6g, Herba Lycopi 57.6g, Borneolum Syntheticum 18g, Camphora 66g.
Take by weighing medicine in proportion, except that Camphora, Borneolum Syntheticum, all the other Herba speranskiae tuberculataes etc. 17 flavor is ground into coarse powder, and with 45% alcohol reflux 3 times, each 3 hours, extracting solution merged, and filtered, filtrate camphorate, Borneolum Syntheticum, mixing promptly gets drug extract.
Embodiment 8:
Herba speranskiae tuberculatae 100g, Radix Aconiti Preparata 45g, Radix Clematidis 70g, Flos Impatientis 70g, Radix Aconiti Kusnezoffii 45g, Stigma Croci 45g, Herba Aristolochiae Mollissimae 70g, Radix Angelicae Pubescentis 45g, Radix Notoginseng 45g, Radix Angelicae Dahuricae 70g, Radix Aucklandiae 48g, windproof 48g, Herba Schizonepetae 48g, Herba Asari 48g, Ramulus Cinnamomi 48g, Radix Achyranthis Bidentatae 48g, Herba Lycopi 48g, Borneolum Syntheticum 15g, Camphora 55g.
Take by weighing medicine in proportion, except that Camphora, Borneolum Syntheticum, all the other Herba speranskiae tuberculataes etc. 17 flavor is ground into coarse powder, and with 70% alcohol reflux 2 times, each 2 hours, extracting solution merged, and filtered, filtrate camphorate, Borneolum Syntheticum, mixing promptly gets drug extract.
Embodiment 9:
Herba speranskiae tuberculatae 100g, Radix Aconiti Preparata 45g, Radix Clematidis 70g, Flos Impatientis 70g, Radix Aconiti Kusnezoffii 45g, Stigma Croci 45g, Herba Aristolochiae Mollissimae 70g, Radix Angelicae Pubescentis 45g, Radix Notoginseng 45g, Radix Angelicae Dahuricae 70g, Radix Aucklandiae 48g, windproof 48g, Herba Schizonepetae 48g, Herba Asari 48g, Ramulus Cinnamomi 48g, Radix Achyranthis Bidentatae 48g, Herba Lycopi 48g, Borneolum Syntheticum 15g, Camphora 55g.
Except that Camphora, Borneolum Syntheticum, 17 flavors such as all the other Herba speranskiae tuberculataes are ground into coarse powder, make solvent with 53% ethanol, flood after 48 hours, filter, and collect medicinal liquid 5300g, and device is preserved in addition; Get Camphora, Borneolum Syntheticum adds ethanol 700g, make dissolving after, with above-mentioned medicinal liquid mixing, be prepared into spray 6000g.
Usage and consumption: external, spray, blow or spread on the affected part, once an amount of, one is for several times.
Embodiment 10:
Choose the drug extract of the arbitrary gained of embodiment 1-8, be prepared into spray 6000ml.
Usage and consumption: external, spray, blow or spread on the affected part, once an amount of, one is for several times.
Embodiment 11:
Choose the drug extract of the arbitrary gained of embodiment 1-8, be prepared into tincture 6000ml.
Usage and consumption: external.2 times on the one, use these article after the affected part cleaned.
Embodiment 12:
Choose the drug extract of the arbitrary gained of embodiment 1-8, concentrate the back and add starch mixing in 1: 1 by extract, crushed after being dried becomes fine powder, sieves; Ethanol with 85% is wetting agent, system granule, 60-70 ℃ of drying; Add 2% Pulvis Talci uniform mixing, be pressed into 2000 in tablet, the 0.4g/ sheet.
Usage and consumption: oral, three times on the one, each 2-4 sheet.
Embodiment 13:
Choose the drug extract of the arbitrary gained of embodiment 1-8, concentrate the back in extract and starch, 1: 1: 2.5 ratio uniform mixing of cane sugar powder, 60-70 ℃ of drying, granule 30000g is processed in packing.
Usage and consumption: boiled water is taken after mixing it with water, and three times on the one, each 10-20g.
Embodiment 14:
Choose the drug extract of the arbitrary gained of embodiment 1-8, concentrate the back and add a certain amount of starch and microcrystalline Cellulose, process 2000 of capsule colloids.
Usage and consumption: oral, three times on the one, each 2-4 grain.
Embodiment 15:
Choose the drug extract of the arbitrary gained of embodiment 1-8, concentrate the back simple syrup and add to sugar content 10%, add 0.2% sodium benzoate, boil dissolving, adding distil water is to full dose, and mixing filters, and oral liquid 30000ml is processed in embedding.
Usage and consumption: oral, three times on the one, each 10ml.
Embodiment 16:
Choose the drug extract of the arbitrary gained of embodiment 1-8, concentrate the back and add surfactant, emulsifying agent, wetting agent, antiseptic or antioxidant, process patch 2000 and paste.
Usage and consumption: external application, dosage is decided according to individual patients.
Claims (7)
1. eliminate limbs tired and the dyskinesia and lenitive Chinese medicine composition for one kind, it is characterized in that: be to process by the effective raw material and the pharmaceutic adjuvant of following weight proportion:
Herba speranskiae tuberculatae 70-130 part; Radix Aconiti Preparata 31.5-58.5 part; Radix Clematidis 49-91 part; Flos Impatientis 49-91 part; Radix Aconiti Kusnezoffii 31.5-58.5 part; Stigma Croci 31.5-58.5 part; Herba Aristolochiae Mollissimae 49-91 part; Radix Angelicae Pubescentis 31.5-58.5 part; Radix Notoginseng 31.5-58.5 part; Radix Angelicae Dahuricae 49-91 part; Radix Aucklandiae 33.6-62.4 part; Windproof 33.6-62.4 part; Herba Schizonepetae 33.6-62.4 part; Herba Asari 33.6-62.4 part; Ramulus Cinnamomi 33.6-62.4 part; Radix Achyranthis Bidentatae 33.6-62.4 part; Herba Lycopi 33.6-62.4 part; Borneolum Syntheticum 10.5-19.5 part; Camphora 38.5-71.5 part.
2. Chinese medicine composition according to claim 1 is characterized in that: be to be processed by the effective raw material and the pharmaceutic adjuvant of following weight proportion:
Herba speranskiae tuberculatae 80-120 part, Radix Aconiti Preparata 36-54 part, Radix Clematidis 56-84 part, Flos Impatientis 56-84 part, Radix Aconiti Kusnezoffii 36-54 part, Stigma Croci 36-54 part, Herba Aristolochiae Mollissimae 56-84 part, Radix Angelicae Pubescentis 36-54 part, Radix Notoginseng 36-54 part, Radix Angelicae Dahuricae 56-84 part, Radix Aucklandiae 38.4-57.6 part, windproof 38.4-57.6 part, Herba Schizonepetae 38.4-57.6 part, Herba Asari 38.4-57.6 part, Ramulus Cinnamomi 38.4-57.6 part, Radix Achyranthis Bidentatae 38.4-57.6 part, Herba Lycopi 38.4-57.6 part, Borneolum Syntheticum 12-18 part, Camphora 44-66 part.
3. Chinese medicine composition according to claim 1 is characterized in that: be to be processed by the effective raw material and the pharmaceutic adjuvant of following weight proportion:
100 parts of Herba speranskiae tuberculataes, 45 parts of Radix Aconiti Preparatas, 70 parts of Radix Clematidis, 70 parts of Flos Impatientiss, 45 parts of Radix Aconiti Kusnezoffii, 45 parts of Stigma Crocis, 70 parts of Herba Aristolochiae Mollissimaes, 45 parts of Radix Angelicae Pubescentiss, 45 parts of Radix Notoginseng, 70 parts of the Radixs Angelicae Dahuricae, 48 parts of the Radix Aucklandiae, windproof 48 parts, Herba Schizonepetae 48,48 parts of Herba Asaris, 48 parts of Ramulus Cinnamomi, 48 parts of Radix Achyranthis Bidentataes, 48 parts of Herba Lycopi, 15 parts of Borneolum Syntheticums, 55 parts of Camphoras.
4. according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that: described Chinese medicine composition is processed spray, tincture, patch, oral liquid, tablet, capsule or granule.
5. according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that:
Method for preparing is: except that Camphora, Borneolum Syntheticum, all the other Herba speranskiae tuberculataes etc. 17 flavor is ground into coarse powder, makes solvent with 45-70% ethanol, flood 24-60 hour or reflux, extract, 2-3 time, and merging filtrate filters, collection medicinal liquid, other device preservation; After getting ethanol that Camphora, Borneolum Syntheticum adds medicinal liquid weight 11%-15% and making dissolving,, be prepared into various preparations according to conventional method with above-mentioned medicinal liquid mixing.
6. according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that:
Method for preparing is: take by weighing medicine in proportion, except that Camphora, Borneolum Syntheticum, 17 flavors such as all the other Herba speranskiae tuberculataes are ground into coarse powder, add 6-10 times of water gaging and decoct extraction 2-3 time; Each 1-3 hour, extracting solution merged, and filtered, and filtrating concentrates; To filtrate under agitation adds ethanol and makes the alcohol amount of containing be 50-70%, leaves standstill 12-24 hour, filters, and collects medicinal liquid; Camphorate, Borneolum Syntheticum, mixing is processed various preparations according to conventional method.
7. Chinese medicine composition according to claim 5 is characterized in that: said spray is preparation like this: (1) takes by weighing raw material by following proportioning: Herba speranskiae tuberculatae 100g, Radix Aconiti Preparata 45g, Radix Clematidis 70g, Flos Impatientis 70g, Radix Aconiti Kusnezoffii 45g, Stigma Croci 45g, Herba Aristolochiae Mollissimae 70g, Radix Angelicae Pubescentis 45g, Radix Notoginseng 45g, Radix Angelicae Dahuricae 70g, Radix Aucklandiae 48g, windproof 48g, Herba Schizonepetae 48g, Herba Asari 48g, Ramulus Cinnamomi 48g, Radix Achyranthis Bidentatae 48g, Herba Lycopi 48g, Borneolum Syntheticum 15g, Camphora 55g.
(2) except that Camphora, Borneolum Syntheticum, 17 flavors such as all the other Herba speranskiae tuberculataes are ground into coarse powder, make solvent with 53% ethanol, flood after 48 hours, filter, and collect medicinal liquid 5300g, and device is preserved in addition; Get Camphora, Borneolum Syntheticum adds ethanol 700g, make dissolving after, with above-mentioned medicinal liquid mixing, be prepared into spray 6000g.
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| CN104645021A (en) * | 2015-03-12 | 2015-05-27 | 肖冻 | Traditional Chinese medicine preparation with effect of eliminating exercise induced physical fatigue |
| CN105560749A (en) * | 2016-02-22 | 2016-05-11 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for treating physical fatigue and preparing method thereof |
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