CN102648950B - Traditional Chinese medicinal composition for eliminating body fatigue and movement disorder and relieving pains - Google Patents
Traditional Chinese medicinal composition for eliminating body fatigue and movement disorder and relieving pains Download PDFInfo
- Publication number
- CN102648950B CN102648950B CN201210126076.XA CN201210126076A CN102648950B CN 102648950 B CN102648950 B CN 102648950B CN 201210126076 A CN201210126076 A CN 201210126076A CN 102648950 B CN102648950 B CN 102648950B
- Authority
- CN
- China
- Prior art keywords
- radix
- herba
- parts
- borneolum syntheticum
- camphora
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The invention discloses a traditional Chinese medicinal composition for eliminating body fatigue and movement disorder and relieving pains. The medicinal composition is prepared from 19 Chinese herbs such as phryma leptostachya, prepared monkshood, radix clematidis, and impatiens balsamina. The traditional Chinese medicinal composition has good therapeutic effects of eliminating the body fatigue and the movement disorder and relieving the pains, can relieve the pains and eliminate inflammation quickly, promotes blood circulation and recover from fatigue; and generally, symptoms are significantly reduced after half an hour.
Description
Technical field
The present invention relates to a kind of allaying tiredness and the dyskinesia, lenitive Chinese medicine composition, belong to the technical field of Chinese medicine.
Background technology
Fatigue is a kind of subjective uncomfortable sensation, but objectively can be under equal conditions, loses it and completes normal activity or the ability to work be originally engaged in, and along with social development, rhythm of life is accelerated, and operating pressure strengthens, usually in a kind of fatigue state; As athlete, usually extremely tired at high-intensity training lower limb body in addition, produce the dyskinesia.As far back as 1880, just the begin one's study mankind's fatigue of Mosso (Mosso).After this, many famous scholars adopt means of different broad research fatigue from multiple visual angle, and successively give tired different concept.Modern Chinese medicine thinks, fatigue is due to the deficiency syndrome and mental change (or not smooth) double factor of first QI consumed wound.In treatment, not only want tonify deficiency righting, tired the calming the nerves of also should dispelling.On the one hand, tonify deficiency primordial QI reinforcing, nourishes body, empty must benefit, and canonical is prosperous, tired from removing; On the other hand, adjust smooth will, comfortable smooth meaning, refreshing must peace, the heart is peaceful, and fatigue can disappear.
Participate in physical training and training and match, to a certain extent time, human body will produce the temporarily-depressed phenomenon of ability to work, and this phenomenon is called sports fatigue.Being mainly manifested in three aspects: muscle fatigue: muscle strength declines, and contraction speed slows down, there is stiff, swelling and pain, slow motion, inharmonious in muscle; Neural fatigue: bradykinesia, misjudge, absent minded; Internal organs fatigue: breathing shoals accelerates, palpitating speed etc.
Sports fatigue belongs to " the power labor " in theory of Chinese medical science, deficiency syndrome should be treated by tonifying method, and the traditional Chinese medical science is many to be controlled from spleen reinforcing opinion.Spleen is " the foundation of acquired constitution ", source of generating QI and blood.The Wei Zhiqi of battalion that the material consumption of motor process depends on the transporting generation of spleen supplements continuously, the qi-blood-body fluid being consumed to maintain motion, and promote the recovery after fatigue.Spleen governing limbs muscle, participates in motion directly.Receiving of taste is normal, and essence derived from food is from prosperous, and change source is no lack of, limb muscle be replenishing vital QI with drugs of warm nature.Motion must rely giving full play to of limb muscle normal function; And the abundant and limbs of the stalwartness of muscle is strong and vigorous flexibly, depend on the healthy and vigorous of temper, transporting is normal.
Due to quantity of motion difference, the fatigue of generation also have in various degree point.Generally fatigue is divided into three levels: slight, moderate and very tired.Slight fatigue can be eliminated at short notice; Moderate fatigue, by taking a series of means can eliminate very soon, can not affect health yet; If but severe fatigue can not eliminate in time, will affect studying and living, damage health.Using Chinese medicine, as the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Radix Notoginseng etc., is all to have the function that regulates central nervous system, and the effect of the strong muscle of coronary artery dilator and QI invigorating, to promoting tired elimination to have good effect.
Pain is the symptom of various diseases, and it makes patient experience painful, and especially severe pain, also may cause physiological function disorder, even shock.Aching pain of muscles has two kinds: one is to occur immediately ache after motion, but it is also very fast to disappear, and is called acute aching pain of muscles; Another kind of not immediate postexercise produces ache, even but just appearance after several hours one nights of sleep after motion disappears also very slowly, couple of days to disappear.This ache is called retardance aching pain of muscles.
Acute aching pain of muscles is usually that oxygen supply is not gone up, and causes lactic acid bulk deposition in muscle because motion is too violent.Lactic acid is a kind of acidic materials, and the not tip of nerve in can stimulated muscle, produces pain perception; In addition, lactic acid is deposited in muscle and can causes local penetration pressure excessive, moisture content around will be inhaled and be come like this, causes muscle edema; The stimulation of this swelling is also the reason that causes aching pain of muscles; Retardance aching pain of muscles, thinks that main muscle fiber has a small amount of tear or the connective tissue of muscle has certain damage to cause after prolonged exercise.
Therefore, suitably drug application alleviating pain, prevents that issuable physiological function disorder from being very necessary.Lenitive medicine, by its pharmacological action and mechanism of action, can be divided into two large classes: first Main Function is in the medicine of central nervous system, optionally elimination or the alleviation pain sensation, in the time of analgesia, Consciousness, other feel unaffected, this class medicine is called analgesic (analgesics), as opiates, be used for severe pain, but application is easy to addiction repeatedly; It two is the medicines with analgesia, antipyretic, antiinflammatory action, effective to various dull pains (as headache, toothache etc.), as ibuprofen, dexamethasone etc.
Current some chemosynthesis class medicines on the market, to allaying tiredness, raising sports achievement, alleviating pain has the effect of short time, but it has larger side effect to human body.Therefore, no matter be fatigue and the dyskinesia that work or motion produce, all little in the urgent need to a kind of side effect, can eliminate fast limbs fatigue, the dyskinesia and lenitive pure Chinese medicinal preparation.
Summary of the invention
The inventor is based on drug world working experience for many years, and experiment and exploration many times, finally successfully develops the present invention.
The object of this invention is to provide elimination limbs fatigue and the dyskinesia and lenitive Chinese medicine composition that a kind of pure Chinese medicine is made.
Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition.
For achieving the above object, the present invention has adopted following technical scheme:
A kind of limbs fatigue and the dyskinesia and lenitive Chinese medicine composition eliminated, calculates according to components by weight percent: be to be made up of effective raw material and the pharmaceutic adjuvant of following weight proportion:
Herba speranskiae tuberculatae 70-130 part, Radix Aconiti Preparata 31.5-58.5 part, Radix Clematidis 49-91 part, Flos Impatientis 49-91 part, Radix Aconiti Kusnezoffii 31.5-58.5 part, Stigma Croci 31.5-58.5 part, Herba Aristolochiae Mollissimae 49-91 part, Radix Angelicae Pubescentis 31.5-58.5 part, Radix Notoginseng 31.5-58.5 part, Radix Angelicae Dahuricae 49-91 part, Radix Aucklandiae 33.6-62.4 part, Radix Saposhnikoviae 33.6-62.4 part, Herba Schizonepetae 33.6-62.4 part, Herba Asari 33.6-62.4 part, Ramulus Cinnamomi 33.6-62.4 part, Radix Achyranthis Bidentatae 33.6-62.4 part, Herba Lycopi 33.6-62.4 part, Borneolum Syntheticum 10.5-19.5 part, Camphora 38.5-71.5 part.
Specifically, described elimination limbs fatigue and the dyskinesia and lenitive Chinese medicine composition, calculate according to components by weight percent: be to be made up of effective raw material and the pharmaceutic adjuvant of following weight proportion:
Herba speranskiae tuberculatae 80-120 part, Radix Aconiti Preparata 36-54 part, Radix Clematidis 56-84 part, Flos Impatientis 56-84 part, Radix Aconiti Kusnezoffii 36-54 part, Stigma Croci 36-54 part, Herba Aristolochiae Mollissimae 56-84 part, Radix Angelicae Pubescentis 36-54 part, Radix Notoginseng 36-54 part, Radix Angelicae Dahuricae 56-84 part, Radix Aucklandiae 38.4-57.6 part, Radix Saposhnikoviae 38.4-57.6 part, Herba Schizonepetae 38.4-57.6 part, Herba Asari 38.4-57.6 part, Ramulus Cinnamomi 38.4-57.6 part, Radix Achyranthis Bidentatae 38.4-57.6 part, Herba Lycopi 38.4-57.6 part, Borneolum Syntheticum 12-18 part, Camphora 44-66 part.
The present invention can also further realize by following optimal technical scheme:
Described elimination limbs fatigue and the dyskinesia and lenitive Chinese medicine composition, calculate according to components by weight percent: be to be made up of effective raw material and the pharmaceutic adjuvant of following weight proportion:
100 parts of Herba speranskiae tuberculataes, 45 parts of Radix Aconiti Preparatas, 70 parts of Radix Clematidis, 70 parts of Flos Impatientiss, 45 parts of Radix Aconiti Kusnezoffii, 45 parts of Stigma Crocis, 70 parts of Herba Aristolochiae Mollissimaes, 45 parts of Radix Angelicae Pubescentiss, 45 parts of Radix Notoginseng, 70 parts of the Radixs Angelicae Dahuricae, 48 parts of the Radix Aucklandiae, 48 parts of Radix Saposhnikoviaes, Herba Schizonepetae 48,48 parts of Herba Asaris, 48 parts of Ramulus Cinnamomi, 48 parts of Radix Achyranthis Bidentataes, 48 parts of Herba Lycopi, 15 parts of Borneolum Syntheticums, 55 parts of Camphoras.
Chinese medicine composition of the present invention, be dispel the wind cold-damp medicine Herba speranskiae tuberculatae, Radix Clematidis, Flos Impatientis, Herba Aristolochiae Mollissimae, Radix Angelicae Pubescentis and Radix Aconiti Radix Aconiti Kusnezoffii be principal agent, Herba speranskiae tuberculatae and Flos Impatientis dispel the wind, invigorate blood circulation, reducing swelling and alleviating pain, Radix Clematidis expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, Herba Aristolochiae Mollissimae dispelling wind and removing obstruction in the collateral, pain relieving, Radix Angelicae Pubescentis expelling wind and dampness, dispersing cold for relieving pain, Radix Aconiti Radix Aconiti Kusnezoffii expelling wind and removing dampness, antalgic, cold expelling detumescence, each medicine improves blood circulation jointly, eliminate exercise fatigue, alleviate pain and detumescence due to fatigue; Collocation wind-cold-dispersing medicinal Ramulus Cinnamomi, Herba Schizonepetae, Radix Saposhnikoviae, the Radix Angelicae Dahuricae and Herba Asari, play the effect of dispersing wind and cold, bone and muscle strengthening; Be aided with in addition pseudo-ginseng blood-circulation-invigovating dredging collateral, removing stasis to stop bleeding, Flos Carthami and Herba Lycopi's promoting blood flow to regulate menstruation, Radix Achyranthis Bidentatae inducing diuresis for treating stranguria syndrome, eliminating blood stasis and inducing menstruation, both strengthened the merit of pseudo-ginseng blood-circulation-invigovating dredging collateral, is conducive to again QI and bloodization raw, eliminates limbs fatigue and the dyskinesia; Muxiangliqi, Borneolum Syntheticum are had one's ideas straightened out, Camphora counteracting toxic substances is antipruritic, contribute to refreshment, pleasant toxic removing.Above-mentioned each medicine is played effect of blood circulation promoting and blood stasis dispelling, dredging collateral QI invigorating, consciousness and resuscitation restoring, reducing swelling and alleviating pain altogether, is very beneficial for eliminating limbs fatigue and the dyskinesia, alleviating pain.
Chinese medicine composition of the present invention, can make the external preparation such as spray, tincture, patch, also can make the oral formulations such as oral liquid, tablet, capsule or granule.
Above-mentioned elimination limbs fatigue and the dyskinesia and lenitive Chinese medicinal composition preparation can be prepared from by the following method:
Except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, make solvent with 45-70% ethanol, flood 24-60 hour or reflux, extract, 2-3 time, and merging filtrate, filters, and collects medicinal liquid, and another device is preserved; After getting ethanol that Camphora, Borneolum Syntheticum adds medicinal liquid weight 11%-15% and making to dissolve, with above-mentioned liquid medicine mixing, be prepared into various required preparations according to conventional method.
Elimination limbs fatigue of the present invention and the dyskinesia and lenitive Chinese medicinal composition preparation also can be prepared from by the following method:
Take in proportion medicine, except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, add 6-10 and doubly measure water boiling and extraction 2-3 time, each 1-3 hour, extracting solution merges, filter, filtrate is concentrated, filtrate is under agitation added to ethanol and make to be 50-70%, to leave standstill 12-24 hour containing alcohol amount, filter, camphorate, Borneolum Syntheticum, mix, make various required preparations according to conventional method.
Below, by the present composition is being eliminated to limbs fatigue and the dyskinesia, the Pharmacodynamic test of active extract example that alleviating pain does to use is further set forth the beneficial effect of medicine of the present invention:
One, the research of present composition removing blood stasis to reduce swelling effect
1. the impact on Rat Models of Traumatic ecchymosis
Grouping and administration: get 50 of SD rats, body weight 180-200g, male and female dual-purpose, is divided into blank group, analgesia collaterals-activating tincture positive controls, the high, medium and low dosage group of extract of the present invention at random.Wherein extract of the present invention adopts embodiment 1-8 either method to prepare.Experiment is lost hair or feathers rat back the previous day with 8% sodium sulfide, then use vice bark pocket skin, causes subcutaneous hemorrhage (area 4 × 4cm
2), after one hour, there is ecchymosis, with being applied to equably ecchymosis place by medicinal liquid, every day twice, observe the ecchymosis situation that disappears every day, the results are shown in Table 1.
The impact (x ± s, n=10) of table 1 on Rat Models of Traumatic ecchymosis
| Group | Number of animals (only) | Dosage (g crude drug/kg) | The ecchymosis natural law that disappears |
| Blank | 10 | -- | 8.2±1.1 |
| Analgesia collaterals-activating tincture | 10 | 2ml | 6.6±1.3** |
| Extract of the present invention | 10 | 0.43 | 6.8±1.2*△ |
| Extract of the present invention | 10 | 0.86 | 6.3±1.1**△ |
| Extract of the present invention | 10 | 1.72 | 6.0±1.2**△ |
Note: with the comparison of blank group, * P < 0.05, * * P < 0.01; With positive controls comparison, △ P > 0.05.
2. the research that pair mice blood stasis model ecchymosis absorbs
Grouping and administration: 50 mices of making subcutaneous ecchymosis model are divided into 5 groups at random, i.e. blank group, analgesia collaterals-activating tincture positive controls, the high, medium and low dosage group of extract of the present invention.Wherein extract of the present invention adopts embodiment 1-8 either method to prepare.After 4 hours, administration immediately after mensuration ecchymosis area, every day is coating on ecchymosis, and one day twice, continuous 7 days.Measure ecchymosis area every day once, relatively the ecchymosis area of ecchymosis extinction time and 1-3 days, the results are shown in Table 2.
The research (x ± s, n=10) that table 2 absorbs the subcutaneous ecchymosis of mice
Note: with the comparison of blank group, * P < 0.05, * * P < 0.01; With positive controls comparison, △ P > 0.05.
Result can find out that the present composition can promote the subcutaneous ecchymosis of mice to absorb, significantly reduce ecchymosis area and shorten its extinction time, and can shorten Rat Models of Traumatic ecchymosis regression time, the prompting present composition can obviously alleviate the symptoms such as the swelling pain that soft tissue injury or osteoarthritis cause, reach blood circulation promoting and blood stasis dispelling, the effect of anti-inflammatory analgetic.
Two, alleviate limbs fatigue and dyskinetic research
1. the impact on mice swimming time
Get 72 of NIH mices, male and female half and half, body weight 18-22g, mice swimming time test method is undertaken by document record routine, the results are shown in Table 3.
The impact (x ± s, n=10) of table 3 on mice swimming time
| Group | Number of animals (only) | Dosage (g crude drug/kg) | Swimming time (second) |
| Blank | 12 | -- | 488.2±71.3 |
| Analgesia collaterals-activating tincture | 12 | 5ml | 538.6±63.1 |
| Bone-setting liquor | 12 | 10ml | 536.3±51.3* |
| Extract of the present invention | 12 | 0.43 | 526.4±45.2*△ |
| Extract of the present invention | 12 | 0.86 | 547.1±44.8*△ |
| Extract of the present invention | 12 | 1.72 | 562.0±51.7*△ |
Note: with the comparison of blank group, * P < 0.05; With positive controls comparison, △ P > 0.05.
2. the impact on mice coordination exercise ability and endurance
Get 90 of NIH mices, male and female half and half, body weight 18-22g, observe (turn/min of rotating speed 12) with rotating rods method, select 60 of the animals that stop more than 3min on rod, be divided at random 5 groups, i.e. normal saline blank group, analgesia collaterals-activating tincture positive controls, the high, medium and low dosage group of extract of the present invention.Medication every day 1 time, the substrate of equivalent for blank group, continuous 7 days, after last administration 1 hour, measure by rotating rods method the number of times that in 5min, each group mice falls from rod, the results are shown in Table 4.
The impact of table 4 present composition on the mice coordination ability and endurance (x ± s)
| Group | Number of animals (only) | Dosage (g crude drug/kg) | Drop number (5min) |
| Blank | 12 | -- | 4.2±1.5 |
| Bone-setting liquor | 12 | 10ml | 2.6±1.3* |
| Extract of the present invention | 12 | 0.43 | 2.8±1.0*△ |
| Extract of the present invention | 12 | 0.86 | 2.5±0.8**△ |
| Extract of the present invention | 12 | 1.72 | 2.2±1.1**△ |
Note: with the comparison of blank group, * P < 0.05, * * P < 0.01; With positive controls comparison, △ P > 0.05.
Above-mentioned experiment shows, the present composition obviously improves the swimming exercise ability of mice, has significantly reduced the number of times that mice falls from rod, and the prompting present composition can be eliminated exercise fatigue, improves sports coordination ability and continuous capability.
Three, athlete tests to pedal
3.1 subjects: selecting certain University Basketball Athletes is subjects, each 10 of men and women, mean age 19.76 ± 1.42, the training time limit 4.51 ± 0.64, height 185 ± 3.24, body weight 68.34 ± 7.23.
3.2 instruments: adopt yueyang, hunan to produce the luxury treadmill formula of EGM-IV heart merit amount machine.
3.3 test methods: experimenter rides on car, zero load full speed treadmill 5s is as warm up, rest 2min, then treadmill, to 60rpm, increases load and in 2-4s, reaches 300W (women 275W), after 300W, makes immediately experimenter's treadmill at full speed, record respectively it at 0-5s, total revolution in treadmill revolution and the 30s of 10s, 20s, tetra-time periods of 30s (every section of 5s), after off-test, loosens and rides 2-3min.
Once measured by the reagent row that advances, give continuously and 7 days tested medicines, again carry out the mensuration of same procedure.Tested medicine is spray prepared by the embodiment of the present invention 9,2 times on the one, once appropriate.
The oscillograph direct-view of SR12A type two wires inputted in the record of heart rate before and after 3.4 motions: adopt CC5 to lead, signal is inputted 6511 type electrocardiograph recorded heart rate simultaneously.Record respectively experimenter when quiet (riding in Power Vehicle), heart rate at once after 30s test.
3.5 the data obtaineds are all processed by statistics, and result is to represent, significance test of difference adopts t check.
3.6 results:
Result compares before and after showing the medication of men and women basket baller treadmill speed sum, and the present composition can increase the total revolution of athlete's treadmill, and after medication seesaws, heart rate also has significant change, increases athlete heart reserve capabillity; Can also obviously alleviate in addition the pain of acute muscle and slow down the persistent period of aching.Point out this compositions to there is the athlete of raising resisting fatigue, improve sports achievement and slow down the effect of limbs pain.Result is as shown in table 5,6,7.
The treadmill revolution of different time sections when table 5 team member 30s test
The variation (b/min) of heart rate before and after table 6 team member 30s test
| Group | n | When quiet | After 30s motion |
| Medicine man | 10 | 65.37±6.46 | 159.64±11.42 |
| Front female | 10 | 67.54±6.18 | 162.78±12.53 |
| Medicine man | 10 | 63.17±5.25 | 137.14±12.57** |
| Rear female | 10 | 64.12±6.33 | 142.68±13.29** |
Acute myalgia situation and the persistent period comparison of aching before and after table 7 test
| Group | n | Myalgia number | Persistent period (min) |
| Medicine man | 10 | 8 | 4.83±0.47 |
| Front female | 10 | 9 | 5.36±0.39 |
| Medicine man | 10 | 6 | 3.12±0.33** |
| Rear female | 10 | 6 | 4.06±0.35** |
Chinese medicine composition of the present invention, proves through zoopery and human experimentation, and for eliminating limbs fatigue and the dyskinesia, alleviating pain has good efficacy, can quickly alleviating pain, antiinflammatory, blood circulation promoting and blood stasis dispelling, set up, and effect is remarkable, has no side effect.
The specific embodiment
Below in conjunction with implementing, the present invention is made to specific description.
Embodiment 1:
Herba speranskiae tuberculatae 100g, Radix Aconiti Preparata 45g, Radix Clematidis 70g, Flos Impatientis 70g, Radix Aconiti Kusnezoffii 45g, Stigma Croci 45g, Herba Aristolochiae Mollissimae 70g, Radix Angelicae Pubescentis 45g, Radix Notoginseng 45g, Radix Angelicae Dahuricae 70g, Radix Aucklandiae 48g, Radix Saposhnikoviae 48g, Herba Schizonepetae 48g, Herba Asari 48g, Ramulus Cinnamomi 48g, Radix Achyranthis Bidentatae 48g, Herba Lycopi 48g, Borneolum Syntheticum 15g, Camphora 55g.
Except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, make solvent with 53% ethanol, flood after 48 hours, filter, and collect medicinal liquid, and another device is preserved; Get the ethanol that Camphora, Borneolum Syntheticum add medicinal liquid weight 13.2%, after making to dissolve, with above-mentioned liquid medicine mixing, obtain drug extract.
Embodiment 2:
Herba speranskiae tuberculatae 90g, Radix Aconiti Preparata 40.5g, Radix Clematidis 63g, Flos Impatientis 63g, Radix Aconiti Kusnezoffii 40.5g, Stigma Croci 40.5g, Herba Aristolochiae Mollissimae 63g, Radix Angelicae Pubescentis 40.5g, Radix Notoginseng 40.5g, Radix Angelicae Dahuricae 63g, Radix Aucklandiae 43.2g, Radix Saposhnikoviae 43.2g, Herba Schizonepetae 43.2g, Herba Asari 43.2g, Ramulus Cinnamomi 43.2g, Radix Achyranthis Bidentatae 43.2g, Herba Lycopi 43.2g, Borneolum Syntheticum 13.5g, Camphora 49.5g.
Except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, make solvent with 70% ethanol, flood after 24 hours, filter, and collect medicinal liquid, and another device is preserved; After getting ethanol that Camphora, Borneolum Syntheticum adds medicinal liquid weight 11% and making to dissolve, with above-mentioned liquid medicine mixing, obtain drug extract.
Embodiment 3:
Herba speranskiae tuberculatae 110g, Radix Aconiti Preparata 49.5g, Radix Clematidis 77g, Flos Impatientis 77g, Radix Aconiti Kusnezoffii 49.5g, Stigma Croci 49.5g, Herba Aristolochiae Mollissimae 77g, Radix Angelicae Pubescentis 49.5g, Radix Notoginseng 49.5g, Radix Angelicae Dahuricae 77g, Radix Aucklandiae 52.8g, Radix Saposhnikoviae 52.8g, Herba Schizonepetae 52.8g, Herba Asari 52.8g, Ramulus Cinnamomi 52.8g, Radix Achyranthis Bidentatae 52.8g, Herba Lycopi 52.8g, Borneolum Syntheticum 52.8g, Camphora 52.8g.
Except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, make solvent with 45% ethanol, flood after 60 hours, filter, and collect medicinal liquid, and another device is preserved; After getting ethanol that Camphora, Borneolum Syntheticum adds medicinal liquid weight 15% and making to dissolve, with above-mentioned liquid medicine mixing, obtain drug extract.
Embodiment 4:
Herba speranskiae tuberculatae 70g, Radix Aconiti Preparata 31.5g, Radix Clematidis 49g, Flos Impatientis 49g, Radix Aconiti Kusnezoffii 31.5g, Stigma Croci 31.5g, Herba Aristolochiae Mollissimae 49g, Radix Angelicae Pubescentis 31.5g, Radix Notoginseng 31.5g, Radix Angelicae Dahuricae 49g, Radix Aucklandiae 33.6g, Radix Saposhnikoviae 33.6g, Herba Schizonepetae 33.6g, Herba Asari 33.64g, Ramulus Cinnamomi 33.6g, Radix Achyranthis Bidentatae 33.6g, Herba Lycopi 33.6g, Borneolum Syntheticum 10.5g, Camphora 38.5g.
Preparation method: take in proportion medicine, except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, add 6 times of amount water boiling and extraction 3 times, each 1 hour, extracting solution merged, filter, filtrate is concentrated, under agitation adds ethanol and makes to be 50%, to leave standstill 24 hours containing alcohol amount, filter, filtrate camphorates, Borneolum Syntheticum, mixes, and obtains drug extract.
Embodiment 5:
Herba speranskiae tuberculatae 130g, Radix Aconiti Preparata 58.5g, Radix Clematidis 91g, Flos Impatientis 91g, Radix Aconiti Kusnezoffii 58.5g, Stigma Croci 58.5g, Herba Aristolochiae Mollissimae 91g, Radix Angelicae Pubescentis 58.5g, Radix Notoginseng 58.5g, Radix Angelicae Dahuricae 91g, Radix Aucklandiae 62.4g, Radix Saposhnikoviae 62.4g, Herba Schizonepetae 62.4g, Herba Asari 62.4g, Ramulus Cinnamomi 62.4g, Radix Achyranthis Bidentatae 62.4g, Herba Lycopi 62.4g, Borneolum Syntheticum 19.5g, Camphora 71.5g.
Take in proportion medicine, except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, add 10 times of amount water boiling and extraction 2 times, each 3 hours, extracting solution merged, filter, filtrate is concentrated, under agitation adds ethanol and makes to be 70%, to leave standstill 12 hours containing alcohol amount, filter, filtrate camphorates, Borneolum Syntheticum, mixes, and obtains drug extract.
Embodiment 6:
Herba speranskiae tuberculatae 80g, Radix Aconiti Preparata 36g, Radix Clematidis 56g, Flos Impatientis 56g, Radix Aconiti Kusnezoffii 36g, Stigma Croci 36g, Herba Aristolochiae Mollissimae 56g, Radix Angelicae Pubescentis 36g, Radix Notoginseng 36g, Radix Angelicae Dahuricae 56g, Radix Aucklandiae 38.4g, Radix Saposhnikoviae 38.4g, Herba Schizonepetae 38.4g, Herba Asari 38.4g, Ramulus Cinnamomi 38.4g, Radix Achyranthis Bidentatae 38.4g, Herba Lycopi 38.4g, Borneolum Syntheticum 12g, Camphora 44g.
Take in proportion medicine, except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, add 8 times of amount water boiling and extraction 2 times, each 2 hours, extracting solution merged, filter, filtrate is concentrated, under agitation adds ethanol and makes to be 60%, to leave standstill 24 hours containing alcohol amount, filter, filtrate camphorates, Borneolum Syntheticum, mixes, and obtains drug extract.
Embodiment 7:
Herba speranskiae tuberculatae 120g, Radix Aconiti Preparata 54g, Radix Clematidis 84g, Flos Impatientis 84g, Radix Aconiti Kusnezoffii 54g, Stigma Croci 54g, Herba Aristolochiae Mollissimae 84g, Radix Angelicae Pubescentis 54g, Radix Notoginseng 54g, Radix Angelicae Dahuricae 84g, Radix Aucklandiae 57.6g, Radix Saposhnikoviae 57.6g, Herba Schizonepetae 57.6g, Herba Asari 57.6g, Ramulus Cinnamomi 57.6g, Radix Achyranthis Bidentatae 57.6g, Herba Lycopi 57.6g, Borneolum Syntheticum 18g, Camphora 66g.
Take in proportion medicine, except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, and with 45% alcohol reflux 3 times, each 3 hours, extracting solution merged, and filtered, and filtrate camphorates, Borneolum Syntheticum, mixes, and obtains drug extract.
Embodiment 8:
Herba speranskiae tuberculatae 100g, Radix Aconiti Preparata 45g, Radix Clematidis 70g, Flos Impatientis 70g, Radix Aconiti Kusnezoffii 45g, Stigma Croci 45g, Herba Aristolochiae Mollissimae 70g, Radix Angelicae Pubescentis 45g, Radix Notoginseng 45g, Radix Angelicae Dahuricae 70g, Radix Aucklandiae 48g, Radix Saposhnikoviae 48g, Herba Schizonepetae 48g, Herba Asari 48g, Ramulus Cinnamomi 48g, Radix Achyranthis Bidentatae 48g, Herba Lycopi 48g, Borneolum Syntheticum 15g, Camphora 55g.
Take in proportion medicine, except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, and with 70% alcohol reflux 2 times, each 2 hours, extracting solution merged, and filtered, and filtrate camphorates, Borneolum Syntheticum, mixes, and obtains drug extract.
Embodiment 9:
Herba speranskiae tuberculatae 100g, Radix Aconiti Preparata 45g, Radix Clematidis 70g, Flos Impatientis 70g, Radix Aconiti Kusnezoffii 45g, Stigma Croci 45g, Herba Aristolochiae Mollissimae 70g, Radix Angelicae Pubescentis 45g, Radix Notoginseng 45g, Radix Angelicae Dahuricae 70g, Radix Aucklandiae 48g, Radix Saposhnikoviae 48g, Herba Schizonepetae 48g, Herba Asari 48g, Ramulus Cinnamomi 48g, Radix Achyranthis Bidentatae 48g, Herba Lycopi 48g, Borneolum Syntheticum 15g, Camphora 55g.
Except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, make solvent with 53% ethanol, flood after 48 hours, filter, and collect medicinal liquid 5300g, and another device is preserved; Get Camphora, Borneolum Syntheticum adds ethanol 700g, make dissolve after, with above-mentioned liquid medicine mixing, be prepared into spray 6000g.
Usage and consumption: external, spray, blow or spread on affected part, once appropriate, one is for several times.
Embodiment 10:
Choose the drug extract of the arbitrary gained of embodiment 1-8, be prepared into spray 6000ml.
Usage and consumption: external, spray, blow or spread on affected part, once appropriate, one is for several times.
Embodiment 11:
Choose the drug extract of the arbitrary gained of embodiment 1-8, be prepared into tincture 6000ml.
Usage and consumption: external.2 times on the one, after being cleaned, affected part uses this product.
Embodiment 12:
Choose the drug extract of the arbitrary gained of embodiment 1-8, add starch mix at 1: 1 after concentrating by extract, crushed after being dried becomes fine powder, sieves, ethanol take 85% is wetting agent, granule processed, and 60-70 ℃ is dry, add 2% Pulvis Talci and evenly mix, be pressed into 2000, tablet, 0.4g/ sheet.
Usage and consumption: oral, three times on the one, each 2-4 sheet.
Embodiment 13:
Choose the drug extract of the arbitrary gained of embodiment 1-8, after concentrating, evenly mix with starch, the cane sugar powder ratio of 1: 1: 2.5 in extract, 60-70 ℃ dry, subpackage granulation agent 30000g.
Usage and consumption: boiled water is taken after mixing it with water, three times on the one, each 10-20g.
Embodiment 14:
Choose the drug extract of the arbitrary gained of embodiment 1-8, after concentrating, add a certain amount of starch and microcrystalline Cellulose, make 2000 of capsule colloids.
Usage and consumption: oral, three times on the one, each 2-4 grain.
Embodiment 15:
Choose the drug extract of the arbitrary gained of embodiment 1-8, concentrated rear simple syrup adds to sugar content 10%, adds 0.2% sodium benzoate, boils dissolving, and adding distil water, to full dose, mixes, and filters, and oral liquid 30000ml is made in embedding.
Usage and consumption: oral, three times on the one, each 10ml.
Embodiment 16:
Choose the drug extract of the arbitrary gained of embodiment 1-8, after concentrating, add surfactant, emulsifying agent, wetting agent, antiseptic or antioxidant, make patch 2000 and paste.
Usage and consumption: external application, dosage is determined according to individual patients.
Claims (7)
1. eliminate limbs fatigue and the dyskinesia and a lenitive Chinese medicine composition, it is characterized in that: be to be made by effective raw material and the pharmaceutic adjuvant of following weight proportion:
Herba speranskiae tuberculatae 70-130 part, Radix Aconiti Preparata 31.5-58.5 part, Radix Clematidis 49-91 part, Flos Impatientis 49-91 part, Radix Aconiti Kusnezoffii 31.5-58.5 part, Stigma Croci 31.5-58.5 part, Herba Aristolochiae Mollissimae 49-91 part, Radix Angelicae Pubescentis 31.5-58.5 part, Radix Notoginseng 31.5-58.5 part, Radix Angelicae Dahuricae 49-91 part, Radix Aucklandiae 33.6-62.4 part, Radix Saposhnikoviae 33.6-62.4 part, Herba Schizonepetae 33.6-62.4 part, Herba Asari 33.6-62.4 part, Ramulus Cinnamomi 33.6-62.4 part, Radix Achyranthis Bidentatae 33.6-62.4 part, Herba Lycopi 33.6-62.4 part, Borneolum Syntheticum 10.5-19.5 part, Camphora 38.5-71.5 part.
2. Chinese medicine composition according to claim 1, is characterized in that: be to be made up of effective raw material and the pharmaceutic adjuvant of following weight proportion:
Herba speranskiae tuberculatae 80-120 part, Radix Aconiti Preparata 36-54 part, Radix Clematidis 56-84 part, Flos Impatientis 56-84 part, Radix Aconiti Kusnezoffii 36-54 part, Stigma Croci 36-54 part, Herba Aristolochiae Mollissimae 56-84 part, Radix Angelicae Pubescentis 36-54 part, Radix Notoginseng 36-54 part, Radix Angelicae Dahuricae 56-84 part, Radix Aucklandiae 38.4-57.6 part, Radix Saposhnikoviae 38.4-57.6 part, Herba Schizonepetae 38.4-57.6 part, Herba Asari 38.4-57.6 part, Ramulus Cinnamomi 38.4-57.6 part, Radix Achyranthis Bidentatae 38.4-57.6 part, Herba Lycopi 38.4-57.6 part, Borneolum Syntheticum 12-18 part, Camphora 44-66 part.
3. Chinese medicine composition according to claim 1, is characterized in that: be to be made up of effective raw material and the pharmaceutic adjuvant of following weight proportion:
100 parts of Herba speranskiae tuberculataes, 45 parts of Radix Aconiti Preparatas, 70 parts of Radix Clematidis, 70 parts of Flos Impatientiss, 45 parts of Radix Aconiti Kusnezoffii, 45 parts of Stigma Crocis, 70 parts of Herba Aristolochiae Mollissimaes, 45 parts of Radix Angelicae Pubescentiss, 45 parts of Radix Notoginseng, 70 parts of the Radixs Angelicae Dahuricae, 48 parts of the Radix Aucklandiae, 48 parts of Radix Saposhnikoviaes, Herba Schizonepetae 48,48 parts of Herba Asaris, 48 parts of Ramulus Cinnamomi, 48 parts of Radix Achyranthis Bidentataes, 48 parts of Herba Lycopi, 15 parts of Borneolum Syntheticums, 55 parts of Camphoras.
4. according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that: described Chinese medicine composition is made spray, tincture, patch, oral liquid, tablet, capsule or granule.
5. according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that:
Preparation method is: except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, make solvent with 45-70% ethanol, floods 24-60 hour or reflux, extract, 2-3 time, and merging filtrate, filters, and collects medicinal liquid, and another device is preserved; After getting ethanol that Camphora, Borneolum Syntheticum adds medicinal liquid weight 11%-15% and making to dissolve, with above-mentioned liquid medicine mixing, be prepared into various preparations according to conventional method.
6. according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that:
Preparation method is: take in proportion medicine, except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, add 6-10 and doubly measure water boiling and extraction 2-3 time, each 1-3 hour, extracting solution merges, filter, filtrate is concentrated, and filtrate is under agitation added to ethanol, and to make containing alcohol amount be 50-70%, leave standstill 12-24 hour, filter, collect medicinal liquid, camphorate, Borneolum Syntheticum, mix, make various preparations according to conventional method.
7. Chinese medicine composition according to claim 5, is characterized in that: preparation method is:
(1) take according to the following ratio raw material: Herba speranskiae tuberculatae 100g, Radix Aconiti Preparata 45g, Radix Clematidis 70g, Flos Impatientis 70g, Radix Aconiti Kusnezoffii 45g, Stigma Croci 45g, Herba Aristolochiae Mollissimae 70g, Radix Angelicae Pubescentis 45g, Radix Notoginseng 45g, Radix Angelicae Dahuricae 70g, Radix Aucklandiae 48g, Radix Saposhnikoviae 48g, Herba Schizonepetae 48g, Herba Asari 48g, Ramulus Cinnamomi 48g, Radix Achyranthis Bidentatae 48g, Herba Lycopi 48g, Borneolum Syntheticum 15g, Camphora 55g;
(2) except Camphora, Borneolum Syntheticum, 17 tastes such as all the other Herba speranskiae tuberculataes are ground into coarse powder, make solvent with 53% ethanol, flood after 48 hours, filter, and collect medicinal liquid 5300g, and another device is preserved; Get Camphora, Borneolum Syntheticum and add ethanol to make three's total amount be 700g, after making to dissolve, with above-mentioned liquid medicine mixing, be prepared into spray 6000g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210126076.XA CN102648950B (en) | 2012-04-20 | 2012-04-20 | Traditional Chinese medicinal composition for eliminating body fatigue and movement disorder and relieving pains |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210126076.XA CN102648950B (en) | 2012-04-20 | 2012-04-20 | Traditional Chinese medicinal composition for eliminating body fatigue and movement disorder and relieving pains |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102648950A CN102648950A (en) | 2012-08-29 |
| CN102648950B true CN102648950B (en) | 2014-05-14 |
Family
ID=46691181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210126076.XA Expired - Fee Related CN102648950B (en) | 2012-04-20 | 2012-04-20 | Traditional Chinese medicinal composition for eliminating body fatigue and movement disorder and relieving pains |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102648950B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230462B (en) * | 2013-05-13 | 2014-09-10 | 戴静宜 | Pain tincture for physiotherapeutic transdermal absorption and treatment of acute and chronic pains |
| CN104645021A (en) * | 2015-03-12 | 2015-05-27 | 肖冻 | Traditional Chinese medicine preparation with effect of eliminating exercise induced physical fatigue |
| CN105616756A (en) * | 2016-01-28 | 2016-06-01 | 申少东 | External spray for efficiently relieving pain |
| CN105687933A (en) * | 2016-02-22 | 2016-06-22 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for relieving exercise-induced fatigue and preparation method thereof |
| CN105582233A (en) * | 2016-02-22 | 2016-05-18 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for relieving fatigue of viscera and preparation method thereof |
| CN105641349A (en) * | 2016-02-22 | 2016-06-08 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition with efficacy of inhibiting generation of lactic acid and preparation method of traditional Chinese medicine composition |
| CN105560749A (en) * | 2016-02-22 | 2016-05-11 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for treating physical fatigue and preparing method thereof |
| CN106138566A (en) * | 2016-07-21 | 2016-11-23 | 夏放军 | One treats physical fatigue Chinese medicinal liquor and preparation method thereof |
| CN107951880B (en) * | 2017-12-05 | 2018-11-27 | 邳州高新区生物医药研究院有限公司 | A kind of benzopyrone is used for as aristolochic acid and the purposes of the attenuation of the Chinese medicine containing aristolochic acid |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424024A (en) * | 2001-10-23 | 2003-06-18 | 罗明新 | External used paste for orthopedic diseases |
| CN1247238C (en) * | 2002-09-11 | 2006-03-29 | 王强 | Chinese medicine ointment preparation for curing hyperosteogeny, pain and numbness and its production method |
| CN1319568C (en) * | 2004-08-27 | 2007-06-06 | 张明友 | Rheumatism treating plaster and its prepn |
| CN101244247B (en) * | 2007-02-16 | 2010-10-13 | 李新华 | Pharmaceutical combination for treating cervical vertebra disease and waist and leg pain, and preparation thereof |
| CN101244252B (en) * | 2008-03-13 | 2011-09-28 | 张金星 | Chinese medicine label for eliminating ache and preparation thereof |
| CN101297946B (en) * | 2008-06-24 | 2011-05-25 | 孙兆印 | Plaster for activating blood and resolving stasis, dispelling wind and freeing collateral vessels and producing method thereof |
| CN101862421B (en) * | 2010-06-09 | 2012-05-30 | 杨青 | Chinese medicinal ointment composition |
-
2012
- 2012-04-20 CN CN201210126076.XA patent/CN102648950B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102648950A (en) | 2012-08-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102648950B (en) | Traditional Chinese medicinal composition for eliminating body fatigue and movement disorder and relieving pains | |
| CN101711850B (en) | Traditional Chinese medicine composition for treating symptoms of myocardial ischemia, palpitation and severe palpitation and preparation method | |
| CN1772194A (en) | Chinese herbal medicine prepn for strengthening kidney-Yang | |
| CN104825591A (en) | Traditional Chinese medicine preparation for treating cervical vertebra diseases and preparation method of traditional Chinese medicine preparation | |
| CN103432390B (en) | Medicament for treating coronary heart disease and preparation method thereof | |
| CN1772196A (en) | Heart failure regulating Chinese medicine | |
| CN101474361B (en) | Chinese medicine for treating cerebropathy | |
| CN103285142A (en) | Traditional Chinese medicine formula for improving brain functions and treating encephalatrophy | |
| CN104107321A (en) | Traditional Chinese medicine composition for treating coronary heart disease | |
| CN101711853B (en) | Traditional Chinese medicine composition for treating symptoms of bradycardia and preparation method thereof | |
| CN103251878B (en) | Anti-fatigue traditional Chinese medicine composition | |
| CN102327436A (en) | Traditional Chinese medicine composition for treating edema during menstruation | |
| CN102349985A (en) | Traditional Chinese medicine composition for treating chronic arrhythmias | |
| CN105561002A (en) | Folium artemisiae argyi health-care foot bath powder and preparation method thereof | |
| CN102579893A (en) | Milkvetch root healthy porridge | |
| CN104352821A (en) | Traditional Chinese medicine granule for treating hypertension | |
| CN103920058A (en) | Traditional Chinese medicine preparation for treating headache and preparation method thereof | |
| CN104825956A (en) | Medicine for preventing and treating stroke and recovering muscles, bones and joints | |
| WO2022160981A1 (en) | Traditional chinese medicine skin-scraping medium and preparation method therefor | |
| CN1709476A (en) | Mine-tranquilizing soporific capsule | |
| CN103028089A (en) | Traditional Chinese medicine composition for treating waist pains of middle-aged and old people | |
| CN103007217A (en) | Chinese medicinal composition for treating hypotension | |
| CN102935185A (en) | Pills for treating neurasthenia and preparation method | |
| CN1259065C (en) | Chinese medicinal preparation for quick bone fracture setting | |
| CN102973687B (en) | Oral liquid for regulating female hormonal balance |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140514 Termination date: 20150420 |
|
| EXPY | Termination of patent right or utility model |