CN104825591A - Traditional Chinese medicine preparation for treating cervical vertebra diseases and preparation method of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for treating cervical vertebra diseases and preparation method of traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine preparation for treating cervical vertebra diseases and a preparation method of the traditional Chinese medicine preparation, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine preparation provided by the invention is prepared by processing the 22 traditional Chinese medicinal materials namely pseudo-ginseng, safflower carthamus, angelica sinensis, scorpio, centipede, herb pyrolae, ramulus mori, radix puerariae, earthworm, uncaria, large-leaved gentian, radix paeoniae alba, notopterygium root, radix achyranthis bidentatae, dogwood, radix clematidis, divaricate saposhnikovia root, salvia miltiorrhiza, cortex acanthopanacis, frankincense, myrrh and liquorice in a ratio according to the preparation method provided by the invention, and the preparation has a quite remarkable treatment effect on the cervical vertebra diseases of cervical vertebra osteoarthritis, proliferative cervical vertebra inflammation, cervical nerve root syndrome, cervical intervertebral disc extrusion and the like; moreover, the preparation is stable in efficacy, less in individual difference, low in preparation process difficulty and low in cost, and easily realizes large-scale production, thus benefiting for more patients.
Description
Technical field
The invention provides a kind of Chinese medicine preparation for the treatment of cervical spondylosis, belong to technical field of Chinese medicines.
Background technology
Western medicine diagnose is thought, cervical spondylosis, also known as cervical spine syndrome, is the general name of osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, Cervical disc extrusion, is a kind of illness changing into basis with degeneration pathology.Strain for a long time mainly due to cervical vertebra, hyperosteogeny, or prolapse of intervertebral disc, ligament thicken, and cause cervical vertebra spinal cord, nerve root or vertebral artery pressurized, occur a series of handicapped clinical syndrome.Show as intervertebral disc degradation itself and insecondary a series of pathological change thereof, as vertebra joint unstability, loosen; Nucleus pulposus or deviate from; Bony spur is formed; The spinal canal stenosis etc. of ligament plumpness and secondary, stimulates or has oppressed the tissues such as the nerve root of vicinity, spinal cord, vertebral artery and cervical region sympathetic nerve, cause series of symptoms and sign.
The traditional Chinese medical science is thought, cervical spondylosis is orthopedics department commonly encountered diseases, frequently-occurring disease, its producing cause, mainly muscles and bones is delayed weak, joint destabilization, add that chronic cumulative bad strains, so that form bony spur gradually, or morphosis changes, as physiological curve straightens, or the joint fissure of displacement etc., finally involve surrounding soft tissue, or nerve, blood vessel, spinal cord, and there is corresponding symptom.Normal bringing out because of affection of exogenous wind-cold or wound is increased the weight of.Due to the difference of affected tissue, clinical manifestation is quite numerous and diverse, and cervical spondylosis is divided into arthralgia pain type by the difference according to clinical manifestation, clinically based on pain, numbness and stiff; Vertiginous type, shows as episodic vertigo, Clear consciousness; Convulsion disease type, orthocolosis contracture is main.
1, arthralgia pain type: with neck and shoulder pain, stiff for primary symptom, or companion side upper limb fiber crops pain, or doublely see breast, backache.The how tight string of arteries and veins, white and thin fur.This is wind-cold damp pathogen, numbness resistance meridians, and the four stages in the course of an epidemic febrile disease is not freely for suffering from.Control warming the meridian and activating blood circulation dredging collateral to be principle.
2, vertiginous type: episodic vertigo, even damping off (but Clear consciousness), often rotates in head and neck and namely sends out as feature.Dizzy pathogenesis forefathers have saying of wind-fire expectorant void.That examines is clinical, and the dizzy of fourth veteran cervical spondylosis is divided into the resistance of collapse of QI, turbid apoplexy due to phlegm, wind and cold bundle network, wind-yang and up-boring four kinds of pattern of syndrome.
(1) collapse of QI type, through cloud: " QI of the upper portion of the body being insufficient, empty sensation in the brain, suffering from the head tilted down feebly, blurring of vision ".Therefore the middle deficiency of vital energy falls into, clear YANG failing to ascend, nutrient blood can not on hold, YANG-orifices failing to be nourished, and occur dizzy, Mental fatigue gas is weak, light red tongue, deep-thready pulse or empty large, blood pressure is on the low side, and controlling should benefiting qi and raising yang method.
(2) turbid apoplexy due to phlegm resistance type, deficiency of both the heart and spleen, raw in sputum, mental disorder is fought mutually, positive position of above overstepping the authority, and hoodwink sun clearly, pretend dizzy, vexed nausea, palpitation with fear feels apprehensive, red tongue greasy fur, stringy pulse or sliding etc., and controlling should expelling phlegm and vanishing turbid pathogen dredging collateral, helps with regulating the stomach and sending down the abnormal ascending QI method.
(3) wind and cold bundle network type, wind and cold visitor is in meridians, and passages through which vital energy circulates contracture is not relaxed, and QI and blood is up smooth, YANG-orifices failing to be nourished and do dizzy, with feeling sick, even vomits.Head and neck rotates or psychokinesia can be fallen ill, stringy and tense pulse, pale tongue with white fur, brain color ultrasound many promptings carotid spasm.Controlling should relaxing muscles and tendons to promote blood circulation method.
(4) on wind sun anti-type through cloud " all wind trembling and dizziness, all belong to liver ".Liver being substantial yin and functional yang, hyperactivity of YANG due to deficiency of YIN, liver-wind is disturbed, and clear key loses peaceful, and send out as dizzy, susceptible to lose temper due to restlessness, red tongue stringy pulse, blood pressure increases.Control suppressing the hyperactive liver to arrest the wind syndrome to be main.
3, convulsion disease (paralysis) type: with unstability of walking, clumsiness of taking a step, foot is felt like jelly as carried out on cotton, and that touches trembles, and in Retarder theory, intermittence carries out increasing the weight of as the one-sided of feature or two motor dysfunction of lower limb.One-tenth " convulsion " person of cervical spondylosis, be the turbid resistance network of the stasis of blood, spasm of muscles and vessels does not relax, and non-operative treatment is rather thorny, to being reluctant operation or do not have surgical condition, insists on the patient of requirement Chinese traditional treatment, active based on blood stasis-eliminating and stagnation-dissipating.
Summary of the invention
The technical problem to be solved in the present invention is a kind of Chinese medicine preparation of invention, make it have better therapeutic effect to cervical spondylosis, and this Chinese medicine preparation can overcome the shortcomings such as Chinese medicine inconvenience is taken, individual drug effect difference is large.
For solving this technical problem, inventor is according to tcm clinical practice experience for many years and studying intensively cervical spondylosis, on the basis of the feature in conjunction with modern Chinese medicine preparation technique, develop a brand-new Chinese prescription, this prescription is not only evident in efficacy, and can adapt to the needs of modern pharmaceutical technology, when being made into finished product Chinese medicine preparation, still can keep good drug effect, the individual variation of patient to drug effect is little, and this Chinese prescription is expressed as with weight portion:
Radix Notoginseng 7-15 part, Flos Carthami 7-17 part, Radix Angelicae Sinensis 8-20 part, Scorpio 4-8 part, Scolopendra 2-6 part, Herba Pyrolae 12-28 part, Ramulus Mori 11-25 part, Radix Puerariae 11-23 part, Pheretima 9-21 part, Ramulus Uncariae Cum Uncis 8-22 part, Radix Gentianae Macrophyllae 8-20 part, Radix Paeoniae Alba 16-28 part, Rhizoma Et Radix Notopterygii 9-21 part, Radix Achyranthis Bidentatae 10-22 part, Fructus Corni 8-20 part, Radix Clematidis 8-18 part, Radix Saposhnikoviae 10-22 part, Radix Salviae Miltiorrhizae 11-25 part, Cortex Acanthopancis 11-27 part, Olibanum 5-11 part, Myrrha 7-15 part, Radix Glycyrrhizae 8-16 part.
Two the prescription proportionings showing better therapeutic effect optimized in practice are:
Proportioning 1: Radix Notoginseng 11 parts, 12 parts, Flos Carthami, Radix Angelicae Sinensis 14 parts, Scorpio 6 parts, Scolopendra 4 parts, Herba Pyrolae 20 parts, Ramulus Mori 18 parts, Radix Puerariae 17 parts, Pheretima 15 parts, Ramulus Uncariae Cum Uncis 15 parts, Radix Gentianae Macrophyllae 14 parts, the Radix Paeoniae Alba 22 parts, Rhizoma Et Radix Notopterygii 15 parts, Radix Achyranthis Bidentatae 16 parts, Fructus Corni 14 parts, Radix Clematidis 13 parts, Radix Saposhnikoviae 16 parts, Radix Salviae Miltiorrhizae 18 parts, Cortex Acanthopancis 19 parts, Olibanum 8 parts, Myrrha 11 parts, 12 parts, Radix Glycyrrhizae.
Proportioning 2: Radix Notoginseng 12 parts, 13 parts, Flos Carthami, Radix Angelicae Sinensis 15 parts, Scorpio 5 parts, Scolopendra 5 parts, Herba Pyrolae 22 parts, Ramulus Mori 17 parts, Radix Puerariae 16 parts, Pheretima 14 parts, Ramulus Uncariae Cum Uncis 16 parts, Radix Gentianae Macrophyllae 16 parts, the Radix Paeoniae Alba 20 parts, Rhizoma Et Radix Notopterygii 14 parts, Radix Achyranthis Bidentatae 17 parts, Fructus Corni 15 parts, Radix Clematidis 16 parts, Radix Saposhnikoviae 15 parts, Radix Salviae Miltiorrhizae 17 parts, Cortex Acanthopancis 17 parts, Olibanum 9 parts, Myrrha 12 parts, 13 parts, Radix Glycyrrhizae.
The preparation method above-mentioned Chinese prescription being made finished product preparation is:
(1) each taste Chinese crude drug is taken respectively by Chinese prescription of the present invention;
(2) Radix Notoginseng, Flos Carthami, Radix Angelicae Sinensis, Scorpio, Scolopendra, Radix Clematidis, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Cortex Acanthopancis, Olibanum, Myrrha are pulverized respectively, levigate, cross 80-130 mesh sieve, obtain fine powder a, for subsequent use;
(3) Herba Pyrolae, Ramulus Mori, Radix Puerariae, Pheretima, Ramulus Uncariae Cum Uncis, Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, Fructus Corni, Radix Glycyrrhizae are pulverized and mixed respectively, add the purified water of initial medical material 6-15 times weight, soak 4-24 hour, backflow decocts 1-6 hour, filters, then adds the purified water of initial weight 4-10 times weight, backflow decocts 1-4 hour, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.17-1.21 is for subsequent use;
(4) filtering residue of step (3) is added the ethanol of the concentration 55-75% of 5-11 times of weight, reflux, extract, 2 times, each 1-5 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.17-1.21 is for subsequent use;
(5) merged by the concentrated solution of step (3) and (4) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, and vacuum drying, to dry extract, is pulverized levigate, crosses 80-130 mesh sieve, obtains fine powder b, for subsequent use;
(6) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make the Chinese medicine finished product preparation of clinical needs, as dosage forms such as pill, capsule (containing soft capsule), powder, tablet, granule, tincture, syrup, patches.
The meridian distribution of property and flavor of Chinese medicine preparation of the present invention Chinese herb used and effect:
Radix Notoginseng: this product is the dry root of panax araliaceae plant.Sweet in the mouth, micro-hardship, warm in nature; Return liver, stomach warp; Dissipating blood stasis stops blooding, subduing swelling and relieving pain.
Flos Carthami: call red indigo plant flower, thorn Flos Carthami, Compositae, Flos Carthami platymiscium.Acrid in the mouth, warm in nature; Enter the heart, Liver Channel; Promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica.Sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Scorpio: this product is the dry body of Buthidae animal Scorpio.Acrid in the mouth, property is put down; Return Liver Channel; Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.
Scolopendra: this product is the dry body of Scolopendridae animal Scolopendpa Subspinipes Mutilans L. KOCH.Acrid in the mouth, warm in nature; Return Liver Channel; Endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain.
Herba Pyrolae: this product is the dry herb of Pyrolaceae plant Herba pyrolae japonicae or ovum leaf Herba pyrolae japonicae.Sweet in the mouth, hardship, warm in nature; Return liver, kidney channel; Wind-damp dispelling, bone and muscle strengthening, hemostasis.
Ramulus Mori: be the twig of moraceae plants Mulberry.Micro-hardship; Property is put down; Enter Liver Channel.Wind-damp dispelling, sharp joint, row aqueous vapor.
Radix Puerariae: this product is the dry root of legume pueraria lobata or Radix Puerariae rattan.Sweet in the mouth, pungent, cool in nature; Return spleen, stomach warp; Expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.
Pheretima: this product is the dry body of Ju Yin section animal Pheretima aspergillum, popular Pheretimatschiliensis, power simulation or the blind Pheretimatschiliensis of comb.Salty in the mouth, cold in nature; Return liver, spleen, urinary bladder channel; Heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis.
Ramulus Uncariae Cum Uncis: this product is the dry stem and branch with belt hook of Maguireothamnus speciosus Ramulus Uncariae Cum Uncis, Ramulus Uncariae macrophyllae, Ramulus Uncariae Cum Uncis, Uncaria sinensis (Oliv.) Havil. or stockless fruit Ramulus Uncariae Cum Uncis.Sweet in the mouth, cool in nature; Return liver, pericardium channel; Heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.
Radix Gentianae Macrophyllae: this product is the dry root of gentianaceae plant Radix Gentianae Macrophyllae, gentiana straminea maxim, gentiana crassicaulis Duthie or Gentiana dahurica.Acrid in the mouth, hardship, property is put down; Return stomach, liver, gallbladder meridian; Wind-damp dispelling, clearing away damp-heat, stopping numbness pain.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae.Bitter in the mouth, acid, cold nature; Return liver, spleen channel; Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Rhizoma Et Radix Notopterygii: this product is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii (back of the body wing celery) or Radix et Rhizoma Notopterygii.Acrid in the mouth, hardship, warm in nature; Return bladder, kidney channel; Cold expelling, dispels the wind, dehumidifying, pain relieving.
Radix Achyranthis Bidentatae: this product is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae.Bitter in the mouth, acid, property is put down; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.
Fructus Corni: this product is the drying and ripening sarcocarp of Cornaceae plant Fructus Corni.Sour in the mouth, puckery, slightly warm in nature; Return liver, kidney channel; Liver and kidney tonifying, essence astringing and desertion stemming.
Radix Clematidis: this product is the dry root and rhizome of ranunculaceae plant Radix Clematidis, Clematis hexapetala (mountain knotweed) or northeast clematis (black common vetch).Acrid in the mouth, salty, warm in nature; Return urinary bladder channel; Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.
Radix Saposhnikoviae: this product is the dry root of umbelliferae Saposhnikovia divaricata.Acrid in the mouth, sweet, warm in nature; Return bladder, liver, spleen channel; Inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.
Radix Salviae Miltiorrhizae: this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.Bitter in the mouth, cold nature; GUIXIN, Liver Channel; Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.
Cortex Acanthopancis: this product is the dry root bark of Araliaceae acanthopanax gracilistylus.Acrid in the mouth, hardship, warm in nature; Return liver, kidney channel; Wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening.
Olibanum: Burseraceae Boswellia carterii platymiscium Boswellia carterii, medicine glue XIANGSHU and wild Boswellia carterii etc., is used as medicine with the oleo-gum-resin that its trunk skin zone wound oozes out.Acrid in the mouth is bitter, warm in nature; Enter the heart, liver, spleen channel; Regulating qi and activating blood, analgesic therapy, chases after poison.
Myrrha: the oleo-gum-resin that Burseraceae bdellium plant myrrh and the trunk skin zone belonging to his kind of plant together ooze out.Bitter in the mouth, property is put down; Enter Liver Channel; Eliminating stasis to stop pain, externally used detumescence granulation promoting.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The side of Chinese prescription of the present invention separates:
This prescription is with Herba Pyrolae, Ramulus Mori, Radix Puerariae, Cortex Acanthopancis, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba for monarch drug, the bone strengthening that dispels the wind, sharp joint, expelling pathogenic factors from muscles for reducing heat, damp eliminating invigorating the liver and kidney, stasis-dispelling and pain-killing, suppressing the hyperactive liver pain relieving; With Radix Achyranthis Bidentatae, Radix Saposhnikoviae, Ramulus Uncariae Cum Uncis, Rhizoma Et Radix Notopterygii, Pheretima, Fructus Corni for ministerial drug, the wet relieving convulsion of eliminating blood stasis and inducing menstruation, victory, heat clearing away suppressing the hyperactive liver, dispersing cold for relieving pain, dredging collateral are relievingd asthma, the liver and the kidney tonifying; With Radix Notoginseng, Flos Carthami, Scorpio, Scolopendra, Radix Clematidis, Radix Gentianae Macrophyllae for adjuvant drug, subduing swelling and relieving pain, promoting blood circulation to restore menstrual flow, endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain, clear wet only numbness; With Radix Angelicae Sinensis, Olibanum, Myrrha for making medicine, enrich blood invigorate blood circulation, analgesic therapy chases after poison, eliminating stasis to stop pain; With all property of medicine of Radix Glycyrrhizae mediation monarch, all medicine negative and positive are taken mutually, attack and defense is had both, combined effect, thus reach eliminating blood stasis and inducing menstruation, the wet relieving convulsion of victory, heat clearing away suppressing the hyperactive liver, dispersing cold for relieving pain, dredging collateral are relievingd asthma, the liver and the kidney tonifying, endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain, analgesic therapy chase after the effects such as poison, all have very significant therapeutic effect to cervical spondylosiss such as osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, Cervical disc extrusions.
Compared with prior art, Chinese medicine preparation of the present invention have that therapeutic effect is good, cure rate is high, more after do not recur, treating both the principal and secondary aspects of a disease, the technical advantage such as medical treatment combination; Its Chinese medicine preparation medicine effect is stable, individual variation is little, and preparation process difficulty is little, cost is low, is easy to large-scale production.
Detailed description of the invention
For the checking feasibility of the Chinese prescription of the present invention and clinical drug effect of Chinese medicine preparation, inventors performed a series of actual production and relevant clinical test, process of the test and result as follows:
Embodiment 1
Minima and best technological parameter production granule by the medical material scope of Chinese prescription of the present invention:
(1) Radix Notoginseng 700g, Flos Carthami 700g, Radix Angelicae Sinensis 800g, Scorpio 400g, Scolopendra 200g, Herba Pyrolae 1200g, Ramulus Mori 1100g, Radix Puerariae 1100g, Pheretima 900g, Ramulus Uncariae Cum Uncis 800g, Radix Gentianae Macrophyllae 800g, Radix Paeoniae Alba 1600g, Rhizoma Et Radix Notopterygii 900g, Radix Achyranthis Bidentatae 1000g, Fructus Corni 800g, Radix Clematidis 800g, Radix Saposhnikoviae 1000g, Radix Salviae Miltiorrhizae 1100g, Cortex Acanthopancis 1100g, Olibanum 500g, Myrrha 700g, Radix Glycyrrhizae 800g is taken respectively by Chinese prescription of the present invention;
(2) Radix Notoginseng, Flos Carthami, Radix Angelicae Sinensis, Scorpio, Scolopendra, Radix Clematidis, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Cortex Acanthopancis, Olibanum, Myrrha are pulverized respectively, levigate, cross 90 mesh sieves, obtain fine powder a, for subsequent use;
(3) Herba Pyrolae, Ramulus Mori, Radix Puerariae, Pheretima, Ramulus Uncariae Cum Uncis, Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, Fructus Corni, Radix Glycyrrhizae are pulverized and mixed respectively, add the purified water of initial medical material 12 times of weight, soak 18 hours, backflow decoction 3 hours, filters, then adds the purified water of initial weight 7 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.17-1.21 is for subsequent use;
(4) filtering residue of step (3) is added the ethanol of the concentration 65% of 8 times of weight, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.17-1.21 is for subsequent use;
(5) merged by the concentrated solution of step (3) and (4) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, and vacuum drying, to dry extract, is pulverized levigate, crosses 90 mesh sieves, obtains fine powder b, for subsequent use;
(6) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make granule, specification: 0.64g crude drug/g granule.
Embodiment 2
Maximum and best technological parameter production granule by the medical material scope of Chinese prescription of the present invention:
(1) Radix Notoginseng 1500g, Flos Carthami 1700g, Radix Angelicae Sinensis 2000g, Scorpio 800g, Scolopendra 600g, Herba Pyrolae 2800g, Ramulus Mori 2500g, Radix Puerariae 2300g, Pheretima 2100g, Ramulus Uncariae Cum Uncis 2200g, Radix Gentianae Macrophyllae 2000g, Radix Paeoniae Alba 2800g, Rhizoma Et Radix Notopterygii 2100g, Radix Achyranthis Bidentatae 2200g, Fructus Corni 2000g, Radix Clematidis 1800g, Radix Saposhnikoviae 2200g, Radix Salviae Miltiorrhizae 2500g, Cortex Acanthopancis 2700g, Olibanum 1100g, Myrrha 1500g, Radix Glycyrrhizae 1600g is taken respectively by Chinese prescription of the present invention;
(2) Radix Notoginseng, Flos Carthami, Radix Angelicae Sinensis, Scorpio, Scolopendra, Radix Clematidis, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Cortex Acanthopancis, Olibanum, Myrrha are pulverized respectively, levigate, cross 90 mesh sieves, obtain fine powder a, for subsequent use;
(3) Herba Pyrolae, Ramulus Mori, Radix Puerariae, Pheretima, Ramulus Uncariae Cum Uncis, Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, Fructus Corni, Radix Glycyrrhizae are pulverized and mixed respectively, add the purified water of initial medical material 12 times of weight, soak 18 hours, backflow decoction 3 hours, filters, then adds the purified water of initial weight 7 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.17-1.21 is for subsequent use;
(4) filtering residue of step (3) is added the ethanol of the concentration 65% of 8 times of weight, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.17-1.21 is for subsequent use;
(5) merged by the concentrated solution of step (3) and (4) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, and vacuum drying, to dry extract, is pulverized levigate, crosses 90 mesh sieves, obtains fine powder b, for subsequent use;
(6) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make granule, specification: 0.64g crude drug/g granule.
Embodiment 3
Granule is produced: Radix Notoginseng 7-15 part by the arbitrary value within the scope of the medical material of Chinese prescription of the present invention and best technological parameter, Flos Carthami 7-17 part, Radix Angelicae Sinensis 8-20 part, Scorpio 4-8 part, Scolopendra 2-6 part, Herba Pyrolae 12-28 part, Ramulus Mori 11-25 part, Radix Puerariae 11-23 part, Pheretima 9-21 part, Ramulus Uncariae Cum Uncis 8-22 part, Radix Gentianae Macrophyllae 8-20 part, Radix Paeoniae Alba 16-28 part, Rhizoma Et Radix Notopterygii 9-21 part, Radix Achyranthis Bidentatae 10-22 part, Fructus Corni 8-20 part, Radix Clematidis 8-18 part, Radix Saposhnikoviae 10-22 part, Radix Salviae Miltiorrhizae 11-25 part, Cortex Acanthopancis 11-27 part, Olibanum 5-11 part, Myrrha 7-15 part, Radix Glycyrrhizae 8-16 part.
(1) Radix Notoginseng 1400g, Flos Carthami 800g, Radix Angelicae Sinensis 900g, Scorpio 700g, Scolopendra 300g, Herba Pyrolae 2700g, Ramulus Mori 1200g, Radix Puerariae 2200g, Pheretima 1000g, Ramulus Uncariae Cum Uncis 2100g, Radix Gentianae Macrophyllae 900g, Radix Paeoniae Alba 2700g, Rhizoma Et Radix Notopterygii 1000g, Radix Achyranthis Bidentatae 2100g, Fructus Corni 900g, Radix Clematidis 1000g, Radix Saposhnikoviae 2100g, Radix Salviae Miltiorrhizae 2400g, Cortex Acanthopancis 1200g, Olibanum 1000g, Myrrha 1400g, Radix Glycyrrhizae 900g is taken respectively by Chinese prescription of the present invention;
(2) Radix Notoginseng, Flos Carthami, Radix Angelicae Sinensis, Scorpio, Scolopendra, Radix Clematidis, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Cortex Acanthopancis, Olibanum, Myrrha are pulverized respectively, levigate, cross 90 mesh sieves, obtain fine powder a, for subsequent use;
(3) Herba Pyrolae, Ramulus Mori, Radix Puerariae, Pheretima, Ramulus Uncariae Cum Uncis, Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, Fructus Corni, Radix Glycyrrhizae are pulverized and mixed respectively, add the purified water of initial medical material 12 times of weight, soak 18 hours, backflow decoction 3 hours, filters, then adds the purified water of initial weight 7 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.17-1.21 is for subsequent use;
(4) filtering residue of step (3) is added the ethanol of the concentration 65% of 8 times of weight, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.17-1.21 is for subsequent use;
(5) merged by the concentrated solution of step (3) and (4) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, and vacuum drying, to dry extract, is pulverized levigate, crosses 90 mesh sieves, obtains fine powder b, for subsequent use;
(6) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make granule, specification: 0.64g crude drug/g granule.
Embodiment 4
Medical material value and best technological parameter production granule by Chinese prescription optimum ratio 1 of the present invention:
(1) Radix Notoginseng 1100g, Flos Carthami 1200g, Radix Angelicae Sinensis 1400g, Scorpio 600g, Scolopendra 400g, Herba Pyrolae 2000g, Ramulus Mori 1800g, Radix Puerariae 1700g, Pheretima 1500g, Ramulus Uncariae Cum Uncis 1500g, Radix Gentianae Macrophyllae 1400g, Radix Paeoniae Alba 2200g, Rhizoma Et Radix Notopterygii 1500g, Radix Achyranthis Bidentatae 1600g, Fructus Corni 1400g, Radix Clematidis 1300g, Radix Saposhnikoviae 1600g, Radix Salviae Miltiorrhizae 1800g, Cortex Acanthopancis 1900g, Olibanum 800g, Myrrha 1100g, Radix Glycyrrhizae 1200g is taken respectively by Chinese prescription of the present invention;
(2) Radix Notoginseng, Flos Carthami, Radix Angelicae Sinensis, Scorpio, Scolopendra, Radix Clematidis, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Cortex Acanthopancis, Olibanum, Myrrha are pulverized respectively, levigate, cross 90 mesh sieves, obtain fine powder a, for subsequent use;
(3) Herba Pyrolae, Ramulus Mori, Radix Puerariae, Pheretima, Ramulus Uncariae Cum Uncis, Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, Fructus Corni, Radix Glycyrrhizae are pulverized and mixed respectively, add the purified water of initial medical material 12 times of weight, soak 18 hours, backflow decoction 3 hours, filters, then adds the purified water of initial weight 7 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.17-1.21 is for subsequent use;
(4) filtering residue of step (3) is added the ethanol of the concentration 65% of 8 times of weight, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.17-1.21 is for subsequent use;
(5) merged by the concentrated solution of step (3) and (4) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, and vacuum drying, to dry extract, is pulverized levigate, crosses 90 mesh sieves, obtains fine powder b, for subsequent use;
(6) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make granule, specification: 0.64g crude drug/g granule.
Embodiment 5
Medical material value and best technological parameter production granule by Chinese prescription optimum ratio 2 of the present invention:
(1) Radix Notoginseng 1200g, Flos Carthami 1300g, Radix Angelicae Sinensis 1500g, Scorpio 500g, Scolopendra 500g, Herba Pyrolae 2200g, Ramulus Mori 1700g, Radix Puerariae 1600g, Pheretima 1400g, Ramulus Uncariae Cum Uncis 1600g, Radix Gentianae Macrophyllae 1600g, Radix Paeoniae Alba 2000g, Rhizoma Et Radix Notopterygii 1400g, Radix Achyranthis Bidentatae 1700g, Fructus Corni 1500g, Radix Clematidis 1600g, Radix Saposhnikoviae 1500g, Radix Salviae Miltiorrhizae 1700g, Cortex Acanthopancis 1700g, Olibanum 900g, Myrrha 1200g, Radix Glycyrrhizae 1300g is taken respectively by Chinese prescription of the present invention;
(2) Radix Notoginseng, Flos Carthami, Radix Angelicae Sinensis, Scorpio, Scolopendra, Radix Clematidis, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Cortex Acanthopancis, Olibanum, Myrrha are pulverized respectively, levigate, cross 90 mesh sieves, obtain fine powder a, for subsequent use;
(3) Herba Pyrolae, Ramulus Mori, Radix Puerariae, Pheretima, Ramulus Uncariae Cum Uncis, Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, Fructus Corni, Radix Glycyrrhizae are pulverized and mixed respectively, add the purified water of initial medical material 12 times of weight, soak 18 hours, backflow decoction 3 hours, filters, then adds the purified water of initial weight 7 times of weight, backflow decoction 2 hours, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.17-1.21 is for subsequent use;
(4) filtering residue of step (3) is added the ethanol of the concentration 65% of 8 times of weight, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.17-1.21 is for subsequent use;
(5) merged by the concentrated solution of step (3) and (4) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, and vacuum drying, to dry extract, is pulverized levigate, crosses 90 mesh sieves, obtains fine powder b, for subsequent use;
(6) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make granule, specification: 0.64g crude drug/g granule.
Embodiment 6
Embodiment of the present invention 1-5 produce the toxicity test of granule
1, test drug: Chinese medicine granules obtained by embodiment of the present invention 1-5, adding distil water is modulated into magma.
Test animal used: regular grade NIH mice, body weight 20g ± 4g, male and female half and half, female mice is all without pregnant; SD rat, original body mass 217 ± 11g, male and female half and half, female rats is all without pregnant.
2, acute toxicity test
Application mice carries out acute toxicity testing and shows: mouse stomach Chinese medicine granules of the present invention, under 741.5g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1.5 hours recover normal, Continuous Observation 7 days after administration, none dead mouse, and overall health of patients, diet, take the photograph water, urine and body weight increase all normal.Experimental result shows: the maximum dosage-feeding of mouse stomach Chinese medicine granules of the present invention is 741.5g crude drug/kg/d(LD
50> 741.5g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.32g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 2317.2 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
3, long term toxicity test
Select SD rat, give the Chinese medicine granules of the present invention of Three doses (being respectively 180,60,20 times of clinical application amount): 57.6g crude drug/kg, 19.2g crude drug/kg, 6.4g crude drug/kg(per weight dosage is by 20 times of calculating of clinical application amount, and clinical application amount is according to the Pharmacopoeia of the People's Republic of China 2010 years versions one).Every day gavage once, continuous 90 days, after last administration 24 hours respectively group live and kill 1/2 animal (male and female half and half), all the other 1/2 animals continue that observations are alive after 2 weeks kills.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal; Within after administration 90 days, within 2 weeks, carry out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.
Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test: Chinese medicine preparation of the present invention has no significant effect rat in high, medium and low three dosage (57.6g crude drug/kg, 19.2g crude drug/kg, 6.4g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention very high.
Embodiment 7
The pharmacodynamic experiment of Chinese medicine preparation of the present invention
1, this product impact that rat paw caused by chondrus ocellatus Holmes is swollen
Get Wistar rat 100, be divided into totally 5 groups such as matched group, Dexamethasone group, the high, medium and low dosage group (experimental drug) of Chinese medicine preparation of the present invention at random, often organize 20.Dexamethasone group dosage: dexamethasone acetate 0.001g/kg.The dosage that invention formulation is high, medium and low group: granule (respectively by clinical 40,20,10 times of admitting dosage) 12.8g crude drug/kg, 6.4g crude drug/kg, 3.2g crude drug/kg that the embodiment of the present invention 4 is produced.Test medicine distilled water is mixed with suspension, and rat every administration 20ml/kg, matched group gives the distilled water of equal volume.Administration every day 1 time, continuous 5 days, 0.5h after last administration, in Rat Right parapodum sole of the foot portion subcutaneous injection (sc) 1% chondrus ocellatus Holmes 0.1ml/ only.Ankle joint girth is measured respectively at the nonelastic tape of 0.5h, 1h, 3h, 5h and 24h before injection chondrus ocellatus Holmes, after injection chondrus ocellatus Holmes.To inject front and back two ankle joint girth differences for swelling, compare the difference between administration group and matched group, and obtain inhibitory rate of intumesce.Result with
represent, t inspection between statistical procedures method employing group.
After each treated animal foot sole of the foot portion injection chondrus ocellatus Holmes different time paw swelling and administration group relative to the inhibitory rate of intumesce of matched group in table 1.
Table 1 Chinese medicine preparation of the present invention on the impact of rat paw edema degree caused by chondrus ocellatus Holmes (
, n=20)
Note: compare with matched group, * P < 0.05, * * P < 0.01, * * * P < 0.001.
Test data display listed by table 1, after each treated animal injection chondrus ocellatus Holmes, different time pedal swelling degree all obviously increases than before injection chondrus ocellatus Holmes, after Chinese medicine preparation 12.8g crude drug of the present invention/kg, 6.4g crude drug/kg, 3.2g crude drug/kg tri-dosage treated animal injection chondrus ocellatus Holmes, 0.5h, 1h, 3h, 5h and 24h swelling is all starkly lower than matched group (P < 0.001, P < 0.01 or P < 0.05), compared with Dexamethasone group, its inhibitory action a little later, but keep time longer.Above-mentioned result of the test shows, Chinese medicine preparation of the present invention has obvious inhibitory action to rat paw edema degree caused by chondrus ocellatus Holmes, therefore illustrates that Chinese medicine preparation of the present invention has stronger detumescencing diuresis, the effect of blood circulation promoting and blood stasis dispelling.
2, this product is on the impact (turbidimetry) of rat platelet maximum agglutination rate
Get Wistar rat 100, be divided into matched group at random; To positive control drug JINGFUKANG KELI 10g crude drug/kg/d group; This product 12.8g crude drug/kg, 6.4g crude drug/kg, 3.2g crude drug/kg group, often organizes 20 by totally 5 groups.Test medicine distilled water is mixed with suspension, rat ig administration 20ml/kg, and matched group gives same volume distilled water, administration every day 1 time, continuous 5 days, 1h after last administration, apparatus 2% cassia oil-petroleum ether silication, pentobarbital sodium is anaesthetized, and aorta gets blood, sodium citrate 9 ﹕ 1 anticoagulant, 1500 to leave heart 20min supernatant be platelet rich plasma (PRP), 4000 to leave heart 20min supernatant be platelet poor plasma (PRP), corrects platelet aggregation instrument, survey maximum platelet aggregation rate.Result represents with ± SD, t inspection between statistical procedures method employing group.After the administration of each treated animal last, 1h maximum platelet aggregation rate is as shown in table 2.
Table 2 Chinese medicine preparation of the present invention on the impact of rat platelet maximum agglutination rate (
, n=20)
As can be seen from the experimental data listed by table 2, the maximum platelet aggregation rate of Chinese medicine preparation 12.8g/kg and 6.4g/kg of the present invention two dosage treated animals is all starkly lower than matched group (being respectively P < 0.01 and P < 0.05).Above-mentioned result of the test shows, Chinese medicine preparation of the present invention has obvious inhibitory action to rat platelet maximum agglutination rate, show that Chinese medicine preparation of the present invention has stronger function of promoting blood circulation to disperse blood clots, and its Be very effective is better than JINGFUKANG KELI.
3, to the inhibitory action of PGE2 synthesis in rat inflammation tissue:
Get rat 100, male and female are regardless of and are divided into 5 groups at random, the high, medium and low dosage of Chinese medicine granules of the present invention, amoxicillin and clavulanate potassium (abbreviation Acker) matched group and blank group, often organize 20.Dosage: this product is high, normal, basic is respectively 12.8g crude drug/kg, 6.4g crude drug/kg, 3.2g crude drug/kg; Acker group is 0.00625g/kg; Successive administration three days, after last medicine 1 hour, right back sufficient subcutaneous injection 1% carrageenin 0.1ml, cause scorching latter 4 hours, put to death rat, on ankle joint, 0.5cm place cuts swelling foot, peeling, shred, normal saline 5ml soaks 1 hour, soak centrifugal (1500rpm) 10 minutes, Aspirate supernatant 0.1ml, add the KOH-MeOH solution 2.0ml of 0.5mol/L, 50 DEG C of constant temperature isomeries 20 minutes, with methanol dilution to 20.0ml, at wavelength 278nm place, measure its absorbance (A) value with UV-2100 ultraviolet spectrophotometer, result with
represent, t inspection between statistical procedures method employing group, result is as shown in table 3.
Table 3 Chinese medicine oral liquid of the present invention on the impact of PGE2 content in inflammatory tissue (
, n=20)
Note: compare * P < 0.05, * * P < 0.01, * * * P < 0.001 with blank group;
Table 3 result shows, and the high, medium and low dosage of Chinese medicine granules of the present invention can suppress the synthesis of PGE2 in rat inflammation tissue respectively to some extent, and high, medium and low dosage has pole significance, very significant and significant difference more respectively with blank group; Point out through statistical procedures: its effect of high dosage intensity is suitable with Acker.
4,0.6%HAC is caused to the analgesic activity of mice pain reaction:
Get male and healthy mice 100, be divided into 5 groups at random, the high, medium and low dosage of Chinese medicine granules of the present invention, JINGFUKANG KELI group and blank group, JINGFUKANG KELI dosage is 10g crude drug/kg/d, other dosage is the same, all by the volume gastric infusion of 0.25ml/10g body weight, blank group gives isopyknic water gastric infusion, for three days on end, and 1 hour lumbar injection 0.6%HAC after mensuration last medicine respectively, 0.1ml/10g Mus is heavy, the writhing number of times that record occurs in the incubation period and 15 minutes of writhing response, by formulae discovery pain suppression ratio (%), result with
represent, t inspection between statistical procedures method employing group, result is as shown in table 4.
Table 4 Chinese medicine oral liquid of the present invention to 0.6%HAC cause mice pain reaction effect (
, n=20)
Note: compare * P < 0.05, * * P < 0.01, * * * P < 0.001 with blank group; Compared with JINGFUKANG group
△p < 0.05,
△ △p < 0.01.
From table 4 result, the high, medium and low dosage of Chinese medicine granules of the present invention all obviously can suppress the writhing incubation period of mice.The significant difference had in various degree is compared with blank group; The high, medium and low dosage of Chinese medicine granules of the present invention all significantly can reduce the writhing number of times of mice, compares with blank group the significant difference had in various degree, points out Chinese medicine preparation granule of the present invention to have good analgesic activity.From pain suppression ratio result: Chinese medicine preparation granule of the present invention three dosage groups are all significantly better than JINGFUKANG group.
Embodiment 8
In order to verify the clinical effectiveness of Chinese medicine preparation of the present invention further, inventor has carried out clinical trial to the granule that the embodiment of the present invention 4 is produced:
1, physical data
The patient of this clinical trial provides by certain city's urgent disorder in orthopaedics hospital, from the 541 routine Patients with Cervical Spondylopathies that this institute accepts for medical treatment year January in February, 2012 to 2015, select be applicable to and be ready participate in clinical trial patient 266 example, age 22-69 year, man 140 example, female 126 example.Wherein osteoarthritis of cervical spine 56 example, proliferative cervical spondylosis 80 example, cervical syndrome 76 example, Cervical disc extrusion 54 example.
2, Therapeutic Method:
The granule that the oral embodiment of the present invention 4 of all patients is produced, every day 2 times, each 15g, 8 hours, interval; Within two weeks, be a course for the treatment of, treat 3 courses for the treatment of continuously.
3, evaluation criterion:
Cure: symptom disappears completely, and make a definite diagnosis through doctor and fully recover;
Effective: symptom makes moderate progress or takes a turn for the better;
Invalid: symptom does not change even more serious.
4, therapeutic outcome:
After test all terminates, by as shown in table 5 for test data statistical analysis:
Table 5 test data statistical analysis table
5, conclusion (of pressure testing):
Add up as can be seen from result of the test, Chinese medicine preparation of the present invention all has good therapeutic effect to the cervical spondylosis of various sign, particularly all very high for cervical syndrome, proliferative cervical spondylosis cure rate and total effective rate, point out Chinese medicine preparation of the present invention to achieve very outstanding technical advantage in treatment cervical spondylosis, obtain creationary progress.
Claims (6)
1. treat the Chinese medicine preparation of cervical spondylosis for one kind, it is characterized in that, the Chinese prescription of described Chinese medicine preparation is expressed as with weight portion: Radix Notoginseng 7-15 part, Flos Carthami 7-17 part, Radix Angelicae Sinensis 8-20 part, Scorpio 4-8 part, Scolopendra 2-6 part, Herba Pyrolae 12-28 part, Ramulus Mori 11-25 part, Radix Puerariae 11-23 part, Pheretima 9-21 part, Ramulus Uncariae Cum Uncis 8-22 part, Radix Gentianae Macrophyllae 8-20 part, Radix Paeoniae Alba 16-28 part, Rhizoma Et Radix Notopterygii 9-21 part, Radix Achyranthis Bidentatae 10-22 part, Fructus Corni 8-20 part, Radix Clematidis 8-18 part, Radix Saposhnikoviae 10-22 part, Radix Salviae Miltiorrhizae 11-25 part, Cortex Acanthopancis 11-27 part, Olibanum 5-11 part, Myrrha 7-15 part, Radix Glycyrrhizae 8-16 part.
2. a kind of Chinese medicine preparation for the treatment of cervical spondylosis as claimed in claim 1, it is characterized in that, the Chinese prescription of described Chinese medicine preparation is expressed as with weight portion: Radix Notoginseng 11 parts, 12 parts, Flos Carthami, Radix Angelicae Sinensis 14 parts, Scorpio 6 parts, Scolopendra 4 parts, Herba Pyrolae 20 parts, Ramulus Mori 18 parts, Radix Puerariae 17 parts, Pheretima 15 parts, Ramulus Uncariae Cum Uncis 15 parts, Radix Gentianae Macrophyllae 14 parts, the Radix Paeoniae Alba 22 parts, Rhizoma Et Radix Notopterygii 15 parts, Radix Achyranthis Bidentatae 16 parts, Fructus Corni 14 parts, Radix Clematidis 13 parts, Radix Saposhnikoviae 16 parts, Radix Salviae Miltiorrhizae 18 parts, Cortex Acanthopancis 19 parts, Olibanum 8 parts, Myrrha 11 parts, 12 parts, Radix Glycyrrhizae.
3. a kind of Chinese medicine preparation for the treatment of cervical spondylosis as claimed in claim 1, it is characterized in that, the Chinese prescription of described Chinese medicine preparation is expressed as with weight portion: Radix Notoginseng 12 parts, 13 parts, Flos Carthami, Radix Angelicae Sinensis 15 parts, Scorpio 5 parts, Scolopendra 5 parts, Herba Pyrolae 22 parts, Ramulus Mori 17 parts, Radix Puerariae 16 parts, Pheretima 14 parts, Ramulus Uncariae Cum Uncis 16 parts, Radix Gentianae Macrophyllae 16 parts, the Radix Paeoniae Alba 20 parts, Rhizoma Et Radix Notopterygii 14 parts, Radix Achyranthis Bidentatae 17 parts, Fructus Corni 15 parts, Radix Clematidis 16 parts, Radix Saposhnikoviae 15 parts, Radix Salviae Miltiorrhizae 17 parts, Cortex Acanthopancis 17 parts, Olibanum 9 parts, Myrrha 12 parts, 13 parts, Radix Glycyrrhizae.
4. prepare as arbitrary in claim 1-3 as described in the method for Chinese medicine preparation for the treatment of cervical spondylosis, it is characterized in that processing step is as follows:
(1) each taste Chinese crude drug is taken respectively by Chinese prescription;
(2) Radix Notoginseng, Flos Carthami, Radix Angelicae Sinensis, Scorpio, Scolopendra, Radix Clematidis, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Cortex Acanthopancis, Olibanum, Myrrha are pulverized respectively, levigate, cross 80-130 mesh sieve, obtain fine powder a, for subsequent use;
(3) Herba Pyrolae, Ramulus Mori, Radix Puerariae, Pheretima, Ramulus Uncariae Cum Uncis, Radix Gentianae Macrophyllae, the Radix Paeoniae Alba, Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, Fructus Corni, Radix Glycyrrhizae are pulverized and mixed respectively, add the purified water of initial medical material 6-15 times weight, soak 4-24 hour, backflow decocts 1-6 hour, filters, then adds the purified water of initial weight 4-10 times weight, backflow decocts 1-4 hour, filter and retain filtering residue, merging filtrate, being concentrated into 55 DEG C of relative densities is that the concentrated solution of 1.17-1.21 is for subsequent use;
(4) filtering residue of step (3) is added the ethanol of the concentration 55-75% of 5-11 times of weight, reflux, extract, 2 times, each 1-5 hour, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of relative densities be that the concentrated solution of 1.17-1.21 is for subsequent use;
(5) merged by the concentrated solution of step (3) and (4) gained, continuing to be concentrated into 55 DEG C of relative densities is the Chinese medical concrete of 1.30-1.35, and vacuum drying, to dry extract, is pulverized levigate, crosses 80-130 mesh sieve, obtains fine powder b, for subsequent use;
(6) by fine powder a and fine powder b mix homogeneously, add suitable adjuvant, utilize modern general Chinese medicine preparation technology, make the Chinese medicine finished product preparation of clinical needs.
5. the Chinese medicine preparation of the treatment cervical spondylosis as described in as arbitrary in claim 1-3, is characterized in that: described Chinese medicine preparation is pill, capsule, powder, tablet, granule, tincture, syrup or patch.
6. the Chinese medicine preparation of the arbitrary described treatment cervical spondylosis of claim 1-3 is the application of the cervical spondylosis characterized in treatment with osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, Cervical disc extrusion.
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| CN106511905A (en) * | 2016-12-20 | 2017-03-22 | 广州聚澜健康产业研究院有限公司 | Traditional Chinese medicine preparation used for curing cervical spondylosis and preparation method thereof |
| CN106728772A (en) * | 2017-03-11 | 2017-05-31 | 张轩焜 | A kind of Chinese medicine and its preparation technology for treating cervical spondylopathy |
| CN109045185A (en) * | 2018-09-12 | 2018-12-21 | 赖庭荣 | A kind of cervical spondylosis emplastrum and preparation method thereof |
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Application publication date: 20150812 |