CN104771529A - Drug for treating traumatic arthritis caused by deficiencies in liver and kidney and preparation method thereof - Google Patents

Abstract

The invention discloses a drug for treating traumatic arthritis caused by deficiencies in the liver and kidney and a preparation method thereof. The drug comprises the following components: abalone shell, corydalis tuber, semen astragali complanati, cibotium rhizome, prepared rehmannia root, Chinese photinia leaf, white peony root, Chinese ilex seed, Ilex cornuta root, bitter orange, sargentgloryvine stem, hemiphragma heterophyllum, banksia rose, combined spicebush, aspongopus, herba lycopi, verbena, dalbergia odorifera, astilbe chinensis, root of delavay schefflera, taxillus chinensis, cortex acanthopanacis, homalomena occulta, and licorice. The drug is mainly used to treat traumatic arthritis caused by deficiencies in liver and kidney, has the functions of tonifying liver, boosting kidney, regulating qi, activating blood, strengthening the muscles and bones, boosting qi, relieving pains, freeing collaterals, and removing stasis, can effectively prevent the disease from degrading and relieve the pains for patients, is capable of treating the disease effectively and acting on the lesions directly, and has the advantages of simple manufacturing technology, prominent effect, short treatment course, low cost, safety, effectiveness, user-friendliness, and easy acceptance.

Description

A kind of medicine and preparation method for the treatment of deficiency of the liver and kidney traumatic arthritis

Technical field

The present invention relates to pharmaceutical technology, particularly relate to a kind of medicine and preparation method for the treatment of deficiency of the liver and kidney traumatic arthritis.

Background technology

Traumatic arthritis is also known as traumatic arthritis, damaging osteoarthritis, it is a kind of osteoarthritis that can prevent of secondary, by wound cause with the cartilage proliferation of the degradation degeneration of articular cartilage and secondary, ossify as main pathological change, a kind of disease being main clinical manifestation with arthralgia, movable function obstacle.Any age group of traumatic arthritis all can be fallen ill, but is more common in the person between twenty and fifty of hobby sports, and what the most often get involved is knee joint, ankle, hip, refer to joints such as (toes).Traumatic arthritis can be subsided by concurrent sclerotin, Subchondral bone sclerosis.Late period then inside knee joint joint space disappear, the subluxation of osteosclerosis knee joint, lower limb malformation.

The pathogenic factor of traumatic arthritis: one, violence wound.Causing fracture, cartilage breakdown, enarthrum in osteoarthrosis to retain as fallen pressure, shock etc., making articular surface out-of-flatness, thus making it suffer abnormal wearing and tearing and destruction; Two, load-bearing is unbalance.As congenital in joint, acquired deformity and the healing of shaft fracture angulation deformity, just do not make the joint heavy burden line of force, the articular surface at long-term pressure-bearing place suffers excessive wear and destruction; Three, activity, heavy burden are excessively.Some joint motion as some Professional Demand human body frequently or often takes certain given pose, or severe simple obesity, or one-sided limbs load-bearing etc. after amputation, all can cause the damage of accumulation property, cause excessive wear and the destruction of the articular surface of corresponding joint.

The Symptoms of traumatic arthritis: early symptom is affected joints pain and stiff, comparatively obvious when coming into play, alleviate after activity, movable many time increase the weight of again, remission after having a rest, pain and activity have obvious relation; Late period, symptom was affected joints swelling repeatedly, and pain lasts also increases the weight of gradually, can occur limitation of activity, hydrarthrosis, deformity and articular mobile corpus, occur coarse friction sound during joint motion.

Traumatic arthritis belongs to the category of the traditional Chinese medical science " rheumatism involving the bone ", and the traditional Chinese medical science is to its differentiation of symptoms and signs for classification of syndrome:

1, damage flesh and blood and coagulate type: primary symptom bone joint pain, pain gesture is violent, like same acupuncture, fixingly not to move, dynamic then aggravate, function limitation, weak breath spontaneous perspiration, dark tongue quality or have ecchymosis, stringy and tense pulse.

2, deficiency of the liver and kidney: primary symptom joint aches, limitation of activity, endlessly continuous, heavy daytime at night is light, lusterless complexion.Relatively deficiency of YIN person, the vexed insomnia of normal companion, dryness of the mouth and throat, feverish sensation in the palms and soles, red tongue, few tongue, stringy and thready pulse.Relatively yang deficiency person, accompany listless, Mental fatigue is breathed hard, hands and feet being not warm, and urine is sharp clearly, and light red tongue, tongue are white, deep,thready and forceless pulse.

3, exopathogen visitor criminal type: primary symptom has damp disease history of catching cold more, chills and pain of the waist and kness, and local is heavy, consciously sends out cool, and obtain Wen Ze and subtract, meet overcast and rainy aggravation, joint motion is limited, light red tongue, white, slippery and moist fur, deep-slow pulse.

The auxiliary examination method of primary disease mainly contains:

1, lab testing: traumatic arthritis does not have specific laboratory examination.Numeration of leukocyte, hematocrit, serum protein electrophoresis all belongs to normal.Except general former osteoarthritis and be attached with except traumatic synovitis, most of case erythrocyte sedimentation rate is normal.

2, x-ray inspection: fracture or after the acute injury of joint, formed gradually in a long time.When injured joints forms degeneration change, display joint space is narrowed, epiphysis hardens, joint margins portion hyperosteogeny is formed, intraarticular may have episome, also can because of epiphysis dysplasia, or bone, leave over cacomelia after joint injury, sometimes merge calcification or ossified in periarticular soft tissues.

The density resolution of 3, CT examination: CT is obviously better than X-ray plain film, is more conducive to the size of clear and definite joint and soft tissue lesions, scope and variable density, and osteopathia is to the invasion and attack of Near tissue.

4, MRI checks: the scope of observable soft tissue and cartilage lesion and internal structure.Though the resolving power of MRI to soft tissue level is better than CT, it to the identification of edema and calcification then not as good as CT.

5, ECT checks: single pass can obtain the scintigram of whole body skeleton, is applicable to do general screening inspection.The sensitivity of ECT is high, therefore can early discovery pathological changes, is conducive to location and quantitative check.

At present, doctor trained in Western medicine is to the treatment of traumatic arthritis, and the main symptomatic treatment of Therapeutic Principle, takes Drug therapy or operative treatment under physician guidance.But western medical treatment side effect is large, antiinflammation pain-stopping pharmaceutical is palliative medicine, based on the symptom that eases the pain, to the patient having high risk factor, after one's own heart, kidney, hepatic insufficiency person, should not use the anti-inflammation analgesic of high-risk side effect, and operative treatment exists risk, postoperative rehabilitation also brings considerable distress to patient.

Chinese traditional treatment traumatic arthritis possesses unique advantage and feature, it utilizes Traditional Chinese medical theory, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, according to disease because of and comprehensive assurance of the state of an illness, dialectical Analyses, science make up a prescription, Mutiple Targets, drug effect is gone directly focus, evident in efficacy, safe and effective, patient is easy to accept, obviously can palliate the agonizing sufferings to patient, fundamentally thoroughly cure traumatic arthritis and do not recur.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of medicine for the treatment of deficiency of the liver and kidney traumatic arthritis, has the liver and the kidney tonifying, vital energy regualting and blood circulation-promoting, effect of bone and muscle strengthening, can play QI invigorating pain relieving, the therapeutical effect of active blood stasis dispelling, effective symptom management development, alleviates patient suffering, fundamentally symptomatic treatment, drug effect is gone directly focus, and processing technology is easy, have evident in efficacy, short treating period, with low cost, safe and effective, convenient drug administration, is easy to the advantage accepted by patient.

For solving the problems of the technologies described above, the invention provides a kind of medicine for the treatment of deficiency of the liver and kidney traumatic arthritis, wherein, following raw medicinal material is comprised: Concha Haliotidis, Rhizoma Corydalis, Semen Astragali Complanati, Rhizoma Cibotii, Radix Rehmanniae Preparata, Folium Photiniae (Folium Photiniae serrulatae), the Radix Paeoniae Alba, Fructus Ilicis Purpureae, Radix Ilicis Cornutae, Fructus Aurantii, Caulis Sargentodoxae, Herba hemipharagmatis heterophylli, the Radix Aucklandiae, the Radix Linderae, Aspongopus, Herba Lycopi, Herba Verbenae, Lignum Dalbergiae Odoriferae, Herba Eupatorii Heterophylli, Radix Schefflerae Delavayi, Herba Taxilli, Cortex Acanthopancis, Rhizoma Homalomenae and Radix Glycyrrhizae.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably: Concha Haliotidis 12-34 part, Rhizoma Corydalis 10-31 part, Semen Astragali Complanati 8-18 part, Rhizoma Cibotii 11-30 part, Radix Rehmanniae Preparata 15-35 part, Folium Photiniae (Folium Photiniae serrulatae) 5-14 part, Radix Paeoniae Alba 10-28 part, Fructus Ilicis Purpureae 7-15 part, Radix Ilicis Cornutae 9-21 part, Fructus Aurantii 13-34 part, Caulis Sargentodoxae 14-32 part, Herba hemipharagmatis heterophylli 7-19 part, Radix Aucklandiae 10-27 part, Radix Linderae 12-25 part, Aspongopus 8-17 part, Herba Lycopi 11-22 part, Herba Verbenae 7-19 part, Lignum Dalbergiae Odoriferae 12-25 part, Herba Eupatorii Heterophylli 6-18 part, Radix Schefflerae Delavayi 10-21 part, Herba Taxilli 12-30 part, Cortex Acanthopancis 7-16 part, Rhizoma Homalomenae 8-17 part and Radix Glycyrrhizae 11-25 part.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Concha Haliotidis 13-32 part, Rhizoma Corydalis 12-30 part, Semen Astragali Complanati 9-16 part, Rhizoma Cibotii 12-28 part, Radix Rehmanniae Preparata 17-34 part, Folium Photiniae (Folium Photiniae serrulatae) 6-12 part, Radix Paeoniae Alba 11-27 part, Fructus Ilicis Purpureae 8-14 part, Radix Ilicis Cornutae 11-20 part, Fructus Aurantii 14-31 part, Caulis Sargentodoxae 15-30 part, Herba hemipharagmatis heterophylli 8-18 part, Radix Aucklandiae 12-26 part, Radix Linderae 13-24 part, Aspongopus 9-16 part, Herba Lycopi 12-21 part, Herba Verbenae 9-18 part, Lignum Dalbergiae Odoriferae 13-24 part, Herba Eupatorii Heterophylli 7-17 part, Radix Schefflerae Delavayi 12-20 part, Herba Taxilli 13-29 part, Cortex Acanthopancis 8-15 part, Rhizoma Homalomenae 10-16 part and Radix Glycyrrhizae 12-23 part.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Concha Haliotidis 31 parts, Rhizoma Corydalis 27 parts, Semen Astragali Complanati 12 parts, Rhizoma Cibotii 25 parts, Radix Rehmanniae Preparata 32 parts, Folium Photiniae (Folium Photiniae serrulatae) 7 parts, the Radix Paeoniae Alba 20 parts, Fructus Ilicis Purpureae 10 parts, Radix Ilicis Cornutae 18 parts, Fructus Aurantii 28 parts, Caulis Sargentodoxae 22 parts, Herba hemipharagmatis heterophylli 12 parts, the Radix Aucklandiae 23 parts, the Radix Linderae 18 parts, Aspongopus 9 parts, Herba Lycopi 17 parts, Herba Verbenae 11 parts, Lignum Dalbergiae Odoriferae 22 parts, Herba Eupatorii Heterophylli 8 parts, Radix Schefflerae Delavayi 18 parts, Herba Taxilli 28 parts, Cortex Acanthopancis 12 parts, Rhizoma Homalomenae 13 parts and 20 parts, Radix Glycyrrhizae.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Concha Haliotidis 30 parts, Rhizoma Corydalis 28 parts, Semen Astragali Complanati 14 parts, Rhizoma Cibotii 27 parts, Radix Rehmanniae Preparata 30 parts, Folium Photiniae (Folium Photiniae serrulatae) 8 parts, the Radix Paeoniae Alba 25 parts, Fructus Ilicis Purpureae 9 parts, Radix Ilicis Cornutae 15 parts, Fructus Aurantii 30 parts, Caulis Sargentodoxae 25 parts, Herba hemipharagmatis heterophylli 10 parts, the Radix Aucklandiae 19 parts, the Radix Linderae 22 parts, Aspongopus 11 parts, Herba Lycopi 13 parts, Herba Verbenae 15 parts, Lignum Dalbergiae Odoriferae 20 parts, Herba Eupatorii Heterophylli 10 parts, Radix Schefflerae Delavayi 15 parts, Herba Taxilli 26 parts, Cortex Acanthopancis 10 parts, Rhizoma Homalomenae 11 parts and 19 parts, Radix Glycyrrhizae.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Concha Haliotidis 29 parts, Rhizoma Corydalis 30 parts, Semen Astragali Complanati 13 parts, Rhizoma Cibotii 26 parts, Radix Rehmanniae Preparata 32 parts, Folium Photiniae (Folium Photiniae serrulatae) 6 parts, the Radix Paeoniae Alba 22 parts, Fructus Ilicis Purpureae 11 parts, Radix Ilicis Cornutae 17 parts, Fructus Aurantii 31 parts, Caulis Sargentodoxae 26 parts, Herba hemipharagmatis heterophylli 9 parts, the Radix Aucklandiae 21 parts, the Radix Linderae 20 parts, Aspongopus 12 parts, Herba Lycopi 19 parts, Herba Verbenae 13 parts, Lignum Dalbergiae Odoriferae 22 parts, Herba Eupatorii Heterophylli 9 parts, Radix Schefflerae Delavayi 16 parts, Herba Taxilli 27 parts, Cortex Acanthopancis 9 parts, Rhizoma Homalomenae 10 parts and 21 parts, Radix Glycyrrhizae.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the pharmaceutical preparation of deficiency of the liver and kidney traumatic arthritis, and when the dosage form of described medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder; Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the pharmaceutical preparation of deficiency of the liver and kidney traumatic arthritis, and when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

The first step, Concha Haliotidis, Rhizoma Corydalis, Semen Astragali Complanati, Rhizoma Cibotii, Radix Rehmanniae Preparata, Folium Photiniae (Folium Photiniae serrulatae), the Radix Paeoniae Alba, Fructus Ilicis Purpureae and Radix Ilicis Cornutae are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 60 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Fructus Aurantii, Caulis Sargentodoxae, Herba hemipharagmatis heterophylli, the Radix Aucklandiae, the Radix Linderae and Aspongopus mix in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 75% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

The present invention also provides a kind of preparation method for the treatment of the pharmaceutical preparation of deficiency of the liver and kidney traumatic arthritis, and when the dosage form of described medicine is honey refining pill, its preparation method comprises the following steps:

The first step, first mixes Concha Haliotidis, Rhizoma Corydalis, Semen Astragali Complanati, Rhizoma Cibotii, Radix Rehmanniae Preparata, Folium Photiniae (Folium Photiniae serrulatae), the Radix Paeoniae Alba, Fructus Ilicis Purpureae, Radix Ilicis Cornutae, Fructus Aurantii, Caulis Sargentodoxae, Herba hemipharagmatis heterophylli and the Radix Aucklandiae in described ratio, and distillation crystallization obtains powder;

Second step, get surplus stock medical material again to mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;

3rd step, adds 4-6 times amount water soaking 1-2.5 hour by step 2 Chinese medicine slag, extract once, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2;

4th step, is condensed into pasty state by said components 1 and component 2 two kinds of extractum, adds the powder that the first step obtains, add Mel and be twisted into pill.

For solving the problems of the technologies described above, the present invention also provides a kind of dosage form for the treatment of deficiency of the liver and kidney traumatic arthritis pharmaceutical composition, and endo-medicine dosage form is preferably: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, syrup; External drug dosage forms is preferably: gel and spray.

Described pharmaceutical composition, medicine is decocted decoction in use and is taken, and every day 1 dose, decocting takes at twice, and every 15 days is a course for the treatment of; When this pharmaceutical composition uses for sucking agent, pill, capsule or tablet, 3 times on the one, every 15 days is a course for the treatment of; When this pharmaceutical composition be gel and spray use time, 3 times on the one, every 15 days is a course for the treatment of.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: utilize the theory of Chinese medical science that China is traditional, the liver and the kidney tonifying, vital energy regualting and blood circulation-promoting, bone and muscle strengthening is main, provides a kind of medicine for the treatment of deficiency of the liver and kidney traumatic arthritis, can QI invigorating pain relieving, active blood stasis dispelling, effective symptom management development, alleviates patient suffering, fundamentally symptomatic treatment, drug effect is gone directly focus, processing technology is easy, has evident in efficacy, short treating period, with low cost, safe and effective, convenient drug administration, is easy to the advantage accepted by patient.

Detailed description of the invention

The invention provides a kind of medicine for the treatment of deficiency of the liver and kidney traumatic arthritis, wherein, following raw medicinal material is comprised: Concha Haliotidis, Rhizoma Corydalis, Semen Astragali Complanati, Rhizoma Cibotii, Radix Rehmanniae Preparata, Folium Photiniae (Folium Photiniae serrulatae), the Radix Paeoniae Alba, Fructus Ilicis Purpureae, Radix Ilicis Cornutae, Fructus Aurantii, Caulis Sargentodoxae, Herba hemipharagmatis heterophylli, the Radix Aucklandiae, the Radix Linderae, Aspongopus, Herba Lycopi, Herba Verbenae, Lignum Dalbergiae Odoriferae, Herba Eupatorii Heterophylli, Radix Schefflerae Delavayi, Herba Taxilli, Cortex Acanthopancis, Rhizoma Homalomenae and Radix Glycyrrhizae.

Wherein, Concha Haliotidis, Rhizoma Corydalis, Semen Astragali Complanati, Rhizoma Cibotii, Radix Rehmanniae Preparata, Folium Photiniae (Folium Photiniae serrulatae), the Radix Paeoniae Alba, Fructus Ilicis Purpureae and contribution root the liver and the kidney tonifying; Fructus Aurantii, Caulis Sargentodoxae, Herba hemipharagmatis heterophylli, the Radix Aucklandiae, the Radix Linderae, Aspongopus, Herba Lycopi, Herba Verbenae and Lignum Dalbergiae Odoriferae vital energy regualting and blood circulation-promoting, blood-activating analgetic; Os Tigris, Herba Eupatorii Heterophylli, Radix Schefflerae Delavayi, Herba Taxilli, Cortex Acanthopancis, Rhizoma Homalomenae and Radix Glycyrrhizae damp eliminating cold expelling, strengthening the tendons and bones.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Concha Haliotidis: salty in the mouth, cold in nature; Return Liver Channel; Suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving; Dizzy for having a headache, cataract, blurring of vision, optic atrohic blindness nyctalopia.

Rhizoma Corydalis: acrid in the mouth, hardship, warm in nature; Return liver, spleen channel; Invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.

Semen Astragali Complanati: another name Tong Fructus Tribuli, the climing Radix Astragali, summer Dendrobium denneanum Kerr., Semen Astragali Complanati are the dry mature seed of leguminous plant astragatus complanatus; Tap plant when time of the year when autumn changes into winter, fruit maturation not yet ftractureed, dry, lay seed, removing impurity, dries; Sweet in the mouth, warm in nature; Return liver, kidney channel; Temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.For lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision.

Rhizoma Cibotii: bitter in the mouth, sweet, warm in nature; Return liver, kidney channel; Invigorating the liver and kidney, strong spinal column, wind-damp dispelling.For soreness of the waist and knees, weakness of the lower extremities, rheumatic arthralgia.

Radix Rehmanniae Preparata: sweet in the mouth, slightly warm in nature; Return liver, kidney channel; Nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.

Folium Photiniae (Folium Photiniae serrulatae): another name stone eye leaves, the old and the young's year leaf, cutter tree, Shi Gang; For the leaf of rosaceous plant Chinese photinia, the whole year can gather, and dries; Acrid in the mouth is bitter, and property is put down; Enter liver, kidney channel; Dispel the wind, dredging collateral, kidney tonifying.Control migratory arthralgia, aching pain in waist and back, flaccidity of the lower limbs of suffering from a deficiency of the kidney, migraine, rubella, the kidney invigorating of dispeling the wind, for bones and muscles pain due to rheumatism, impotence and seminal emission.

The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature; Return liver, spleen channel; Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.

Fructus Ilicis Purpureae: sweet in the mouth, hardship, cool in nature; Return liver, kidney channel; Invigorating the liver and kidney, curing rheumatism, arresting bleeding and healing up ulcer.Main early whitening of beard and hair, rheumatic arthralgia, digestive ulcerative bleeding, hemorrhoid, ulcer being unable to heal

Radix Ilicis Cornutae: be the root bark of holly plant Ilex cornuta Lindl., the whole year can adopt, cleans and dries.Bitter in the mouth, cool in nature; The liver and the kidney tonifying, wind and heat dispersing.Main waist knee flaccidity, arthralgia, wind syndrome of head, acute conjunctivitis, toothache, the diseases such as urticaria.

Fructus Aurantii: bitter in the mouth, pungent, sour, warm in nature; Return spleen, stomach warp; Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official such as to prolapse the disease.

Caulis Sargentodoxae: bitter in the mouth, property is put down; Return large intestine, Liver Channel; Heat-clearing and toxic substances removing, invigorates blood circulation, and dispels the wind.For abdominalgia with intestinal abscess, amenorrhea dysmenorrhea, rheumatic arthralgia, the diseases such as tumbling and swelling.

Herba hemipharagmatis heterophylli: another name Herba Violae mundae, the red decorative pearl on top of an official cap, the decorative pearl on top of an official cap grass, bottom line fruit, Radix Ginseng Rubra, Semen Phaseoli, Fructus Piperis, change leaf, Glechota longituba (Nakai) Kupr month in and month out, Scrophulariaceae diversifolious hemiphragma herb platymiscium diversifolious hemiphragma herb, with all herbal medicine.Xia Qiu gathers, and cleans, using fresh herb or dry; Taste is micro-sweet, warm in nature; GUIXIN, Liver Channel; Expelling wind and removing dampness, heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.Main air pain of dampness syndrome, amenorrhea is suffered from abdominal pain, scrofula, and skin ulcer swells the diseases such as noxious dampness, pharyngalgia, gingivitis, traumatic injury.

The Radix Aucklandiae: acrid in the mouth is bitter, warm in nature; Enter lung, liver, spleen channel; Promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach.Control the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain, vomiting, has loose bowels, dysentery tenesmus, the diseases such as colic of cold type.

The Radix Linderae: another name sky Radix Linderae, Radix Linderae, short Camphor tree, fragrant osmanthus Camphor tree, copper coin bavin, Ban Pichai are the dried root of the canella Radix Linderae.The whole year all can excavate, and removing radicula, cleans, take advantage of fresh slices, dry, or directly dry.Acrid in the mouth, warm in nature; Return lung, spleen, kidney, urinary bladder channel; Pleasant pain relieving, warming kidney for dispelling cold; For chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia, the diseases such as dysmenorrhea.

Aspongopus: be the dry body of Pentatomidae Insects Aspongopus, caught before March November to next year.Put in appropriate vessel, suffocated a little with wine, taking-up is dried in the shade; Or put in boiling water boiling hot dead, and take out, dry; Salty in the mouth, warm in nature; Return liver,spleen,kidney warp; Regulating QI to relieve pain, warming middle-JIAO is supporing yang.For cold syndrome of the stomach distending pain, stomachache due to hyperactive liver-QI attacking the stomach, impotence due to deficiency of the kidney, the diseases such as soreness of waist and knee joint.

Herba Lycopi: bitter in the mouth, pungent, slightly warm in nature; Return liver, spleen channel; Blood circulation promoting and blood stasis dispelling, line water detumescence, removing toxicity for eliminating carbuncles.Housewife female's amenorrhea, dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen edema, traumatic injury, the diseases such as carbuncle sore tumefacting virus.

Herba Verbenae: bitter in the mouth, pungent, cold nature; Return liver, spleen channel; Heat-clearing and toxic substances removing, promoting blood circulation to restore menstrual flow, inducing diuresis to remove edema, preventing the attack (or recurrence) of malaria.Main cold, fever, laryngopharynx swelling and pain, gingival swelling and pain, jaundice, dysentery, blood stasis amenorrhea, dysmenorrhea, lump in the abdomen, edema, dysuria, malaria, carbuncle pyogenic infections from tumour or sore, the diseases such as traumatic injury.

Lignum Dalbergiae Odoriferae: acrid in the mouth, warm in nature; Return liver, spleen channel; Promoting flow of QI and blood, pain relieving, hemostasis.For epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, the diseases such as traumatic hemorrhage.

Herba Eupatorii Heterophylli: call that golden hair Radix Notoginseng, three spends seven, negative and positive tiger, tiger fiber crops, art are lived, iron Rhizoma Cimicifugae, for Saxifragaceae astilbe Herba astilbes chinensis is with root stock or all herbal medicine.Autumn takes root stock, and removing fibrous root, cleans, and section, dries, or grubs out and get.Dry for subsequent use.Acrid in the mouth, hardship, warm in nature; Return Liver Channel; Promoting blood circulation and stopping pain, expelling wind and removing dampness, strengthening the tendons and bones, removing toxic substances.Main amenorrhea, lump in the abdomen, traumatic injury, orchitis, the diseases such as venom.

Radix Schefflerae Delavayi: another name bubble is logical, clematis biondiana Pavolini, meal Bao Ye, trident wood, Semen Sojae Preparatum leaf logical every son, large Semen Sojae Preparatum leaf, cattle throat pipe, handle of umbrella are wooden, great Tong Ta, and Araliaceae Schefflera plant carries on the back schefflera is in vain used as medicine with root, stem, bark, leaf.The whole year can adopt, and bark is cleaned, and steam thoroughly, cutting, dries, and leaf can using fresh herb.Mildly bitter flavor, puckery, property is put down; Dispelling, collateral-activating, strengthening the tendons and bones, promoting flow of QI and blood.Main air pain of dampness syndrome, soreness of waist and knee joint, treating swelling and pain by traumatic injury, the diseases such as breast side of body abdominal distention.

Herba Taxilli: bitter in the mouth, sweet, property is put down; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; The diseases such as hypertension.

Cortex Acanthopancis: acrid in the mouth, hardship, warm in nature; Return liver, kidney channel; Wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening.For rheumatic arthralgia, muscles and bones flaccidity is soft, children's's walking retardation in children, and body void is weak, edema, beriberi.

Rhizoma Homalomenae: another name Rhizoma Homalomenae, thousand pins, Rhizoma Homalomenae, silk crest lines, for Araeceae puts down a dry rhizome for taro platymiscium Rhizoma Homalomenae.Spring, Qiu Erji excavate, and clean, and removing crust, dries.Bitter in the mouth, pungent, warm in nature; Return liver, kidney channel; Wind-damp dispelling, muscle reinforcing and bone strengthening, promoting blood circulation and stopping pain.For anemofrigid-damp arthralgia, chills and pain of the waist and kness, lower limb contracture is numb.

Radix Glycyrrhizae: sweet in the mouth, property is put down, GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, the disease such as strong.

Wherein, in medicine, the ratio of weight and number of each raw medicinal material can be preferably: Concha Haliotidis 12-34 part, Rhizoma Corydalis 10-31 part, Semen Astragali Complanati 8-18 part, Rhizoma Cibotii 11-30 part, Radix Rehmanniae Preparata 15-35 part, Folium Photiniae (Folium Photiniae serrulatae) 5-14 part, Radix Paeoniae Alba 10-28 part, Fructus Ilicis Purpureae 7-15 part, Radix Ilicis Cornutae 9-21 part, Fructus Aurantii 13-34 part, Caulis Sargentodoxae 14-32 part, Herba hemipharagmatis heterophylli 7-19 part, Radix Aucklandiae 10-27 part, Radix Linderae 12-25 part, Aspongopus 8-17 part, Herba Lycopi 11-22 part, Herba Verbenae 7-19 part, Lignum Dalbergiae Odoriferae 12-25 part, Herba Eupatorii Heterophylli 6-18 part, Radix Schefflerae Delavayi 10-21 part, Herba Taxilli 12-30 part, Cortex Acanthopancis 7-16 part, Rhizoma Homalomenae 8-17 part and Radix Glycyrrhizae 11-25 part.

Wherein, in medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Concha Haliotidis 13-32 part, Rhizoma Corydalis 12-30 part, Semen Astragali Complanati 9-16 part, Rhizoma Cibotii 12-28 part, Radix Rehmanniae Preparata 17-34 part, Folium Photiniae (Folium Photiniae serrulatae) 6-12 part, Radix Paeoniae Alba 11-27 part, Fructus Ilicis Purpureae 8-14 part, Radix Ilicis Cornutae 11-20 part, Fructus Aurantii 14-31 part, Caulis Sargentodoxae 15-30 part, Herba hemipharagmatis heterophylli 8-18 part, Radix Aucklandiae 12-26 part, Radix Linderae 13-24 part, Aspongopus 9-16 part, Herba Lycopi 12-21 part, Herba Verbenae 9-18 part, Lignum Dalbergiae Odoriferae 13-24 part, Herba Eupatorii Heterophylli 7-17 part, Radix Schefflerae Delavayi 12-20 part, Herba Taxilli 13-29 part, Cortex Acanthopancis 8-15 part, Rhizoma Homalomenae 10-16 part and Radix Glycyrrhizae 12-23 part.

Wherein, in medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Concha Haliotidis 31 parts, Rhizoma Corydalis 27 parts, Semen Astragali Complanati 12 parts, Rhizoma Cibotii 25 parts, Radix Rehmanniae Preparata 32 parts, Folium Photiniae (Folium Photiniae serrulatae) 7 parts, the Radix Paeoniae Alba 20 parts, Fructus Ilicis Purpureae 10 parts, Radix Ilicis Cornutae 18 parts, Fructus Aurantii 28 parts, Caulis Sargentodoxae 22 parts, Herba hemipharagmatis heterophylli 12 parts, the Radix Aucklandiae 23 parts, the Radix Linderae 18 parts, Aspongopus 9 parts, Herba Lycopi 17 parts, Herba Verbenae 11 parts, Lignum Dalbergiae Odoriferae 22 parts, Herba Eupatorii Heterophylli 8 parts, Radix Schefflerae Delavayi 18 parts, Herba Taxilli 28 parts, Cortex Acanthopancis 12 parts, Rhizoma Homalomenae 13 parts and 20 parts, Radix Glycyrrhizae.

Wherein, in medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Concha Haliotidis 30 parts, Rhizoma Corydalis 28 parts, Semen Astragali Complanati 14 parts, Rhizoma Cibotii 27 parts, Radix Rehmanniae Preparata 30 parts, Folium Photiniae (Folium Photiniae serrulatae) 8 parts, the Radix Paeoniae Alba 25 parts, Fructus Ilicis Purpureae 9 parts, Radix Ilicis Cornutae 15 parts, Fructus Aurantii 30 parts, Caulis Sargentodoxae 25 parts, Herba hemipharagmatis heterophylli 10 parts, the Radix Aucklandiae 19 parts, the Radix Linderae 22 parts, Aspongopus 11 parts, Herba Lycopi 13 parts, Herba Verbenae 15 parts, Lignum Dalbergiae Odoriferae 20 parts, Herba Eupatorii Heterophylli 10 parts, Radix Schefflerae Delavayi 15 parts, Herba Taxilli 26 parts, Cortex Acanthopancis 10 parts, Rhizoma Homalomenae 11 parts and 19 parts, Radix Glycyrrhizae.

Wherein, in medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Concha Haliotidis 29 parts, Rhizoma Corydalis 30 parts, Semen Astragali Complanati 13 parts, Rhizoma Cibotii 26 parts, Radix Rehmanniae Preparata 32 parts, Folium Photiniae (Folium Photiniae serrulatae) 6 parts, the Radix Paeoniae Alba 22 parts, Fructus Ilicis Purpureae 11 parts, Radix Ilicis Cornutae 17 parts, Fructus Aurantii 31 parts, Caulis Sargentodoxae 26 parts, Herba hemipharagmatis heterophylli 9 parts, the Radix Aucklandiae 21 parts, the Radix Linderae 20 parts, Aspongopus 12 parts, Herba Lycopi 19 parts, Herba Verbenae 13 parts, Lignum Dalbergiae Odoriferae 22 parts, Herba Eupatorii Heterophylli 9 parts, Radix Schefflerae Delavayi 16 parts, Herba Taxilli 27 parts, Cortex Acanthopancis 9 parts, Rhizoma Homalomenae 10 parts and 21 parts, Radix Glycyrrhizae.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the pharmaceutical preparation of deficiency of the liver and kidney traumatic arthritis, and when the dosage form of medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder; Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the pharmaceutical preparation of deficiency of the liver and kidney traumatic arthritis, and when the dosage form of medicine is capsule, its preparation method comprises the following steps:

The first step, Concha Haliotidis, Rhizoma Corydalis, Semen Astragali Complanati, Rhizoma Cibotii, Radix Rehmanniae Preparata, Folium Photiniae (Folium Photiniae serrulatae), the Radix Paeoniae Alba, Fructus Ilicis Purpureae and Radix Ilicis Cornutae are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 60 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Fructus Aurantii, Caulis Sargentodoxae, Herba hemipharagmatis heterophylli, the Radix Aucklandiae, the Radix Linderae and Aspongopus mix in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 75% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

The present invention also provides a kind of preparation method for the treatment of the pharmaceutical preparation of deficiency of the liver and kidney traumatic arthritis, and when the dosage form of medicine is for during for honey refining pill, its preparation method comprises the following steps:

The first step, first mixes Concha Haliotidis, Rhizoma Corydalis, Semen Astragali Complanati, Rhizoma Cibotii, Radix Rehmanniae Preparata, Folium Photiniae (Folium Photiniae serrulatae), the Radix Paeoniae Alba, Fructus Ilicis Purpureae, Radix Ilicis Cornutae, Fructus Aurantii, Caulis Sargentodoxae, Herba hemipharagmatis heterophylli and the Radix Aucklandiae in described ratio, and distillation crystallization obtains powder;

Second step, get surplus stock medical material again to mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;

3rd step, adds 4-6 times amount water soaking 1-2.5 hour by step 2 Chinese medicine slag, extract once, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2;

4th step, is condensed into pasty state by said components 1 and component 2 two kinds of extractum, adds the powder that the first step obtains, add Mel and be twisted into pill.

Described medicine, medicine is decocted decoction in use and is taken, and every day 1 dose, decocting takes at twice, and every 15 days is a course for the treatment of; When this medicine uses for sucking agent, pill, capsule or tablet, 3 times on the one, every 15 days is a course for the treatment of; When this medicine be gel and spray use time, 3 times on the one, every 15 days is a course for the treatment of.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 granule of the present invention

Embodiments provide a kind of medicine for the treatment of deficiency of the liver and kidney traumatic arthritis, obtained by the raw medicinal material of following weight: Concha Haliotidis 31g, Rhizoma Corydalis 27g, Semen Astragali Complanati 12g, Rhizoma Cibotii 25g, Radix Rehmanniae Preparata 32g, Folium Photiniae (Folium Photiniae serrulatae) 7g, Radix Paeoniae Alba 20g, Fructus Ilicis Purpureae 10g, Radix Ilicis Cornutae 18g, Fructus Aurantii 28g, Caulis Sargentodoxae 22g, Herba hemipharagmatis heterophylli 12g, Radix Aucklandiae 23g, Radix Linderae 18g, Aspongopus 9g, Herba Lycopi 17g, Herba Verbenae 11g, Lignum Dalbergiae Odoriferae 22g, Herba Eupatorii Heterophylli 8g, Radix Schefflerae Delavayi 18g, Herba Taxilli 28g, Cortex Acanthopancis 12g, Rhizoma Homalomenae 13g and Radix Glycyrrhizae 20g.

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 90%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 1.6ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.06, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 82 DEG C, be ground into powder subsequently, make dried cream powder; Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.15 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.

Embodiment 2 capsule of the present invention

Embodiments provide a kind of medicine for the treatment of deficiency of the liver and kidney traumatic arthritis, obtained by the raw medicinal material of following weight: Concha Haliotidis 30g, Rhizoma Corydalis 28g, Semen Astragali Complanati 14g, Rhizoma Cibotii 27g, Radix Rehmanniae Preparata 30g, Folium Photiniae (Folium Photiniae serrulatae) 8g, Radix Paeoniae Alba 25g, Fructus Ilicis Purpureae 9g, Radix Ilicis Cornutae 15g, Fructus Aurantii 30g, Caulis Sargentodoxae 25g, Herba hemipharagmatis heterophylli 10g, Radix Aucklandiae 19g, Radix Linderae 22g, Aspongopus 11g, Herba Lycopi 13g, Herba Verbenae 15g, Lignum Dalbergiae Odoriferae 20g, Herba Eupatorii Heterophylli 10g, Radix Schefflerae Delavayi 15g, Herba Taxilli 26g, Cortex Acanthopancis 10g, Rhizoma Homalomenae 11g and Radix Glycyrrhizae 19g.

Its preparation method comprises the following steps:

The first step, Concha Haliotidis, Rhizoma Corydalis, Semen Astragali Complanati, Rhizoma Cibotii, Radix Rehmanniae Preparata, Folium Photiniae (Folium Photiniae serrulatae), the Radix Paeoniae Alba, Fructus Ilicis Purpureae and Radix Ilicis Cornutae are mixed in described ratio, add the water extraction volatile oil relative to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 5, stirs 80 minutes, temperature 45 C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.16;

Second step, Fructus Aurantii, Caulis Sargentodoxae, Herba hemipharagmatis heterophylli, the Radix Aucklandiae, the Radix Linderae and Aspongopus mix in described ratio, add relative to mixture 7 times amount determining alcohol be 85% alcohol reflux 4 times, each 2.5 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.21, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times of water gagings, boil 7 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.29;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 65 DEG C of reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 6 weight portion carboxymethyl starch sodium, 30 weight starch mix homogeneously, adding 170 weight portion determining alcohols is 85% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 4 weight portion magnesium stearate, then load in gelatine capsule.

Embodiment 3 honey refining of the present invention pill

Embodiments provide a kind of medicine for the treatment of deficiency of the liver and kidney traumatic arthritis, obtained by the raw medicinal material of following weight: Concha Haliotidis 29g, Rhizoma Corydalis 30g, Semen Astragali Complanati 13g, Rhizoma Cibotii 26g, Radix Rehmanniae Preparata 32g, Folium Photiniae (Folium Photiniae serrulatae) 6g, Radix Paeoniae Alba 22g, Fructus Ilicis Purpureae 11g, Radix Ilicis Cornutae 17g, Fructus Aurantii 31g, Caulis Sargentodoxae 26g, Herba hemipharagmatis heterophylli 9g, Radix Aucklandiae 21g, Radix Linderae 20g, Aspongopus 12g, Herba Lycopi 19g, Herba Verbenae 13g, Lignum Dalbergiae Odoriferae 22g, Herba Eupatorii Heterophylli 9g, Radix Schefflerae Delavayi 16g, Herba Taxilli 27g, Cortex Acanthopancis 9g, Rhizoma Homalomenae 10g and Radix Glycyrrhizae 21g.

Its preparation method comprises the following steps:

The first step, first mixes Concha Haliotidis, Rhizoma Corydalis, Semen Astragali Complanati, Rhizoma Cibotii, Radix Rehmanniae Preparata, Folium Photiniae (Folium Photiniae serrulatae), the Radix Paeoniae Alba, Fructus Ilicis Purpureae, Radix Ilicis Cornutae, Fructus Aurantii, Caulis Sargentodoxae, Herba hemipharagmatis heterophylli and Rosa Banksiae Ait in described ratio, and distillation crystallization obtains powder;

Second step, get surplus stock medical material again to mix in described ratio, add 87% soak with ethanol 1.5 hours, the heating extraction 2 times relative to mixture 4 times amount, each 1.5 hours, merge extractive liquid, 130 orders filter, be the ultrafiltration post ultrafiltration of 72000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;

3rd step, adds 5 times amount water soaking 2 hours by step 2 Chinese medicine slag, extract once, extraction time is 1.5 hours, and thickening filtration is extractum shape, is component 2;

4th step, is condensed into pasty state by said components 1 and component 2 two kinds of extractum, adds the powder that the first step obtains, add Mel and be twisted into pill.

Acute toxicity test:

Application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The honey refining pill prepared by embodiments of the invention 3 is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage honey refining of the present invention pill LD50>32.9 crude drug/kg, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage medicine of the present invention is 901 times of quantity.Therefore the honey refining pill acute toxicity of the embodiment of the present invention 3 is low, clinical drug safety.

Long term toxicity test:

The granule of the embodiment of the present invention 1 presses 10.78,20.35 and 33.48g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that the granule of the embodiment of the present invention 1 is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

The capsule of the embodiment of the present invention 2 presses 10.78,20.35 and 33.48g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that the capsule of the embodiment of the present invention 2 is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: Qu Liangsuo hospital in March, 2012 to 2013 deficiency of the liver and kidney traumatic arthritis patient 196 example that year December is accepted for medical treatment as object of study, wherein male patient 102 example, female patient 94 example, the age 16-56 year, thoughtful 5 years of medical history one.Be divided into four groups at random, the ordinary circumstance of four groups of patients, as the no difference of science of statistics such as age, the course of disease, has comparability.

Granules in Treating group: 49 people, male 26 people, female 23 people.

Capsule treatment group: 49 people, male 25 people, female 24 people.

Honey refining pill treatment group: 49 people, male 26 people, female 23 people.

Western medicine group: 49 people, male 25 people, female 24 people.

Diagnostic criteria:

1, have chronic accumulation joint injury history or have obvious trauma history, pathogenic process is slow;

2, early stage affected joints is ached, and motion stiff sense takes a turn for the better after movable, but after overwork, symptom increases the weight of again;

3, arthralgia is relevant with activity the later stage, can occur that coarse friction is felt, can occur locked joint or articular mobile corpus, joint deformity time movable;

4, X-ray examination, visible joint gap turn narrow cartilage inferior articular surface sclerosis joint margins has varying degree bony spur to be formed.Can occur that articular surface is not whole late period, epiphysis is out of shape, and intraarticular has episome.

The traditional Chinese medical science is to the diagnostic criteria of deficiency of the liver and kidney traumatic arthritis: joint aches, and limitation of activity is endlessly continuous, and heavy daytime at night is light, lusterless complexion.Relatively deficiency of YIN person, the vexed insomnia of normal companion, dryness of the mouth and throat, feverish sensation in the palms and soles, red tongue, few tongue, stringy and thready pulse.Relatively yang deficiency person, accompany listless, Mental fatigue is breathed hard, hands and feet being not warm, and urine is sharp clearly, and light red tongue, tongue are white, deep,thready and forceless pulse.

Therapeutic Method:

Granules in Treating group: use granule prepared by the embodiment of the present invention 1, every day 3 times, each 1 bag 15 days is 1 course for the treatment of.

Capsule treatment group: use capsule prepared by the embodiment of the present invention 2, every day 3 times, each 2 15 days is 1 course for the treatment of.

Honey refining pill treatment group: the honey refining pill using the embodiment of the present invention 3 to prepare, every day 3 times, each 2 15 days is 1 course for the treatment of.

Western medicine group: Aspirin sheet, each 1g, every day 3 times; Smear diclofenac diethylamine emulgel, use according to sore spot size, every day 3 times 15 days is 1 course for the treatment of.

Curative effect determinate standard:

Draft with reference to " People's Republic of China's traditional Chinese medicine industry standard disease of tcm Standardization of diagnosis and curative effect " rheumatism involving the bone card.

Cure: arthralgia, swelling disappear, movable function recovers normal;

Effective: slight arthralgia, swelling, movable function is intact;

Take a turn for the better: arthralgia, swelling alleviate, movable function takes a turn for the better;

Invalid: arthralgia and swelling unchanged or increase the weight of.

Therapeutic outcome:

1, adopt Drug therapy deficiency of the liver and kidney traumatic arthritis of the present invention, treat after 30 days, relative to Western medicine on therapeutic effect, there is significant improvement.

Granules in Treating group, totally 49 people, wherein 24 people cure, and 17 people are effective, and 8 people take a turn for the better, and total effective rate reaches 100%;

Capsule treatment group, totally 49 people, wherein 22 people cure, and 20 people are effective, and 6 people take a turn for the better, and 1 people is invalid, and total effective rate reaches 98%;

Honey refining pill treatment group, totally 49 people, wherein 27 people cure, and 19 people are effective, and 3 people take a turn for the better, and total effective rate reaches 100%;

Western medicine group, totally 49 people, wherein 18 people cure, and 14 people are effective, and 8 people take a turn for the better, and 9 people are invalid, and total effective rate reaches 81.6%.

As can be seen here, the relative Western medicine of Drug therapy treatment deficiency of the liver and kidney traumatic arthritis of the present invention, effective percentage is high.

2, adopt Drug therapy deficiency of the liver and kidney traumatic arthritis of the present invention, treat after 30 days, cure, effective and take a turn for the better number, relative to Western medicine treatment the course for the treatment of on significantly shorten.

Granules in Treating group, healing, effective and improvement number 49 people, wherein 1-10 days, 12 people, account for 24.5%; 11-20 days, 20 people, account for 40.8%; 21-30 days, 17 people, account for 34.7%.

Capsule treatment group, healing, effective and improvement number 48 people, wherein 1-10 days, 13 people, account for 27.1%; 11-20 days, 19 people, account for 39.6%; 21-30 days, 16 people, account for 33.3%.

Honey refining pill treatment group, healing, effective and improvement number 49 people, wherein 1-10 days, 15 people, account for 30.6%; 11-20 days, 21 people, account for 42.9%; 21-30 days, 13 people, account for 26.5%.

Western medicine group, healing, effective and improvement number 40 people, wherein 1-10 days, 4 people, account for 10%; 11-20 days, 9 people, account for 22.5%; 21-30 days, 27 people, account for 67.5%.

As can be seen here, the relative Western medicine of Drug therapy deficiency of the liver and kidney traumatic arthritis of the present invention, curative effect is fast.

According to the clinical statistics that above curative effect is stated, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.

Model case: suffer from Wu, 35 years old, sports enthusiast, right arm elbow joint is ached, swelling, and limitation of activity, have stiff sense during motion, take a turn for the better after movable, but after crossing sports, symptom increases the weight of again, sense of aching is light for heavy daytime at night, and often feels dryness of the mouth and throat, feverish sensation in the palms and soles, red tongue, few tongue.Hospital is gone to be diagnosed as deficiency of the liver and kidney traumatic arthritis.Take the granule of pharmaceutical preparation embodiment 1 of the present invention, every day 3 times, each 1 bag, treat after 10 days, joint only has slight pain, swelling, and movable function recovers substantially, and continue to take medicine 4 days, arthralgia, swelling disappear completely, and movable function recovers normal.Patient, to the very satisfaction of this curative effect, follows up a case by regular visits to and does not recur so far.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (9)

1. treat the medicine of deficiency of the liver and kidney traumatic arthritis for one kind, it is characterized in that, comprise following raw medicinal material: Concha Haliotidis, Rhizoma Corydalis, Semen Astragali Complanati, Rhizoma Cibotii, Radix Rehmanniae Preparata, Folium Photiniae (Folium Photiniae serrulatae), the Radix Paeoniae Alba, Fructus Ilicis Purpureae, Radix Ilicis Cornutae, Fructus Aurantii, Caulis Sargentodoxae, Herba hemipharagmatis heterophylli, the Radix Aucklandiae, the Radix Linderae, Aspongopus, Herba Lycopi, Herba Verbenae, Lignum Dalbergiae Odoriferae, Herba Eupatorii Heterophylli, Radix Schefflerae Delavayi, Herba Taxilli, Cortex Acanthopancis, Rhizoma Homalomenae and Radix Glycyrrhizae.

2. medicine as claimed in claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Concha Haliotidis 12-34 part, Rhizoma Corydalis 10-31 part, Semen Astragali Complanati 8-18 part, Rhizoma Cibotii 11-30 part, Radix Rehmanniae Preparata 15-35 part, Folium Photiniae (Folium Photiniae serrulatae) 5-14 part, Radix Paeoniae Alba 10-28 part, Fructus Ilicis Purpureae 7-15 part, Radix Ilicis Cornutae 9-21 part, Fructus Aurantii 13-34 part, Caulis Sargentodoxae 14-32 part, Herba hemipharagmatis heterophylli 7-19 part, Radix Aucklandiae 10-27 part, Radix Linderae 12-25 part, Aspongopus 8-17 part, Herba Lycopi 11-22 part, Herba Verbenae 7-19 part, Lignum Dalbergiae Odoriferae 12-25 part, Herba Eupatorii Heterophylli 6-18 part, Radix Schefflerae Delavayi 10-21 part, Herba Taxilli 12-30 part, Cortex Acanthopancis 7-16 part, Rhizoma Homalomenae 8-17 part and Radix Glycyrrhizae 11-25 part.

3. medicine as claimed in claim 1 or 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Concha Haliotidis 13-32 part, Rhizoma Corydalis 12-30 part, Semen Astragali Complanati 9-16 part, Rhizoma Cibotii 12-28 part, Radix Rehmanniae Preparata 17-34 part, Folium Photiniae (Folium Photiniae serrulatae) 6-12 part, Radix Paeoniae Alba 11-27 part, Fructus Ilicis Purpureae 8-14 part, Radix Ilicis Cornutae 11-20 part, Fructus Aurantii 14-31 part, Caulis Sargentodoxae 15-30 part, Herba hemipharagmatis heterophylli 8-18 part, Radix Aucklandiae 12-26 part, Radix Linderae 13-24 part, Aspongopus 9-16 part, Herba Lycopi 12-21 part, Herba Verbenae 9-18 part, Lignum Dalbergiae Odoriferae 13-24 part, Herba Eupatorii Heterophylli 7-17 part, Radix Schefflerae Delavayi 12-20 part, Herba Taxilli 13-29 part, Cortex Acanthopancis 8-15 part, Rhizoma Homalomenae 10-16 part and Radix Glycyrrhizae 12-23 part.

4. the medicine as described in as arbitrary in claims 1 to 3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Concha Haliotidis 31 parts, Rhizoma Corydalis 27 parts, Semen Astragali Complanati 12 parts, Rhizoma Cibotii 25 parts, Radix Rehmanniae Preparata 32 parts, Folium Photiniae (Folium Photiniae serrulatae) 7 parts, the Radix Paeoniae Alba 20 parts, Fructus Ilicis Purpureae 10 parts, Radix Ilicis Cornutae 18 parts, Fructus Aurantii 28 parts, Caulis Sargentodoxae 22 parts, Herba hemipharagmatis heterophylli 12 parts, the Radix Aucklandiae 23 parts, the Radix Linderae 18 parts, Aspongopus 9 parts, Herba Lycopi 17 parts, Herba Verbenae 11 parts, Lignum Dalbergiae Odoriferae 22 parts, Herba Eupatorii Heterophylli 8 parts, Radix Schefflerae Delavayi 18 parts, Herba Taxilli 28 parts, Cortex Acanthopancis 12 parts, Rhizoma Homalomenae 13 parts and 20 parts, Radix Glycyrrhizae.

5. the medicine as described in as arbitrary in claims 1 to 3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Concha Haliotidis 30 parts, Rhizoma Corydalis 28 parts, Semen Astragali Complanati 14 parts, Rhizoma Cibotii 27 parts, Radix Rehmanniae Preparata 30 parts, Folium Photiniae (Folium Photiniae serrulatae) 8 parts, the Radix Paeoniae Alba 25 parts, Fructus Ilicis Purpureae 9 parts, Radix Ilicis Cornutae 15 parts, Fructus Aurantii 30 parts, Caulis Sargentodoxae 25 parts, Herba hemipharagmatis heterophylli 10 parts, the Radix Aucklandiae 19 parts, the Radix Linderae 22 parts, Aspongopus 11 parts, Herba Lycopi 13 parts, Herba Verbenae 15 parts, Lignum Dalbergiae Odoriferae 20 parts, Herba Eupatorii Heterophylli 10 parts, Radix Schefflerae Delavayi 15 parts, Herba Taxilli 26 parts, Cortex Acanthopancis 10 parts, Rhizoma Homalomenae 11 parts and 19 parts, Radix Glycyrrhizae.

6. the medicine as described in as arbitrary in claims 1 to 3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Concha Haliotidis 29 parts, Rhizoma Corydalis 30 parts, Semen Astragali Complanati 13 parts, Rhizoma Cibotii 26 parts, Radix Rehmanniae Preparata 32 parts, Folium Photiniae (Folium Photiniae serrulatae) 6 parts, the Radix Paeoniae Alba 22 parts, Fructus Ilicis Purpureae 11 parts, Radix Ilicis Cornutae 17 parts, Fructus Aurantii 31 parts, Caulis Sargentodoxae 26 parts, Herba hemipharagmatis heterophylli 9 parts, the Radix Aucklandiae 21 parts, the Radix Linderae 20 parts, Aspongopus 12 parts, Herba Lycopi 19 parts, Herba Verbenae 13 parts, Lignum Dalbergiae Odoriferae 22 parts, Herba Eupatorii Heterophylli 9 parts, Radix Schefflerae Delavayi 16 parts, Herba Taxilli 27 parts, Cortex Acanthopancis 9 parts, Rhizoma Homalomenae 10 parts and 21 parts, Radix Glycyrrhizae.

7. the medicine as described in as arbitrary in claim 1 to 6, it is characterized in that, when the dosage form of described medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder; Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

8. the medicine as described in as arbitrary in claim 1 to 6, it is characterized in that, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

The first step, Concha Haliotidis, Rhizoma Corydalis, Semen Astragali Complanati, Rhizoma Cibotii, Radix Rehmanniae Preparata, Folium Photiniae (Folium Photiniae serrulatae), the Radix Paeoniae Alba, Fructus Ilicis Purpureae and Radix Ilicis Cornutae are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 60 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Fructus Aurantii, Caulis Sargentodoxae, Herba hemipharagmatis heterophylli, the Radix Aucklandiae, the Radix Linderae and Aspongopus mix in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 75% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

9. according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is honey refining pill, its preparation method comprises the following steps:

The first step, Concha Haliotidis, Rhizoma Corydalis, Semen Astragali Complanati, Rhizoma Cibotii, Radix Rehmanniae Preparata, Folium Photiniae (Folium Photiniae serrulatae), the Radix Paeoniae Alba, Fructus Ilicis Purpureae, Radix Ilicis Cornutae, Fructus Aurantii, Caulis Sargentodoxae, Herba hemipharagmatis heterophylli and the Radix Aucklandiae mix in described ratio, and distillation crystallization obtains powder;

Second step, get surplus stock medical material again to mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;

3rd step, adds 4-6 times amount water soaking 1-2.5 hour by step 2 Chinese medicine slag, extract once, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2;

4th step, is condensed into pasty state by said components 1 and component 2 two kinds of extractum, adds the powder that the first step obtains, add Mel and be twisted into pill.